keyword
MENU ▼
Read by QxMD icon Read
search

Neuroborreliosis

keyword
https://www.readbyqxmd.com/read/27885483/neuroborreliosis
#1
John J Halperin
Appropriate, critical application of evidence-based diagnostic criteria enables both a clear definition of what constitutes neuroborreliosis-nervous system infection with Borrelia burgdorferi sensu stricto in the US, B garinii and less commonly B. afzelii and other species in Europe-and recognition that this disorder is quite similar in Europe and the US. Most commonly evidenced by lymphocytic meningitis and/or multifocal inflammation of the peripheral (common; cranial neuropathy, radiculopathy, mononeuropathy multiplex) or central (rare) nervous system, it is readily diagnosed and highly antibiotic responsive...
November 24, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27847963/-challenge-of-neuroborreliosis
#2
A Spreer, S Rauer, H Wilking, V Fingerle
Lyme borreliosis is the most frequent tick-borne infection in Europe. It is a multisystemic disease affecting the skin, joints, heart, in rare cases the eyes and regularly the nervous system. Taking current clinical and microbiological guidelines into account, neuroborreliosis can in general be diagnosed and treated successfully. An appropriate guideline-conform antibiotic treatment is effective and in most cases recovery from acute neuroborreliosis is complete. Nevertheless, the evidence base regarding pharmacological treatment needs reform and improvement...
November 15, 2016: Der Nervenarzt
https://www.readbyqxmd.com/read/27832501/phospholipidomic-analysis-reveals-changes-in-sphingomyelin-and-lysophosphatidylcholine-profiles-in-plasma-from-patients-with-neuroborreliosis
#3
W Łuczaj, P Domingues, M R Domingues, S Pancewicz, E Skrzydlewska
In recent years, the number of patients suffering from Lyme Disease (LD) has significantly increased. The most dangerous manifestation of LD is neuroborreliosis associated with invasion of the central nervous system by Borrelia burgdorferi. Phospholipids (PL) and their metabolites are involved in inflammation, which plays a dominant, but still unclear, role in the pathogenesis of neuroborreliosis. We analyzed the plasma PL profiles of neuroborreliosis patients (n = 8) and healthy volunteers (n = 8) using a lipidomic approach...
November 10, 2016: Lipids
https://www.readbyqxmd.com/read/27820708/lyme-neuroborreliosis
#4
Uwe Koedel, Hans-Walter Pfister
PURPOSE OF REVIEW: Lyme disease is a multistage and multisystem disease. Neurological manifestations [termed Lyme neuroborreliosis (LNB)] occur in about 10% of patients with Lyme disease. Diagnostics and treatment of early and late LNB are widely established. However, the management of persistent symptoms is still fraught with controversies, and therefore is the focus of this review. RECENT FINDINGS: The incidence of Lyme disease seems to be much higher than previously assumed...
November 4, 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27756335/cerebrospinal-fluid-cytokines-in-lyme-neuroborreliosis
#5
Annukka Pietikäinen, Mikael Maksimow, Tommi Kauko, Saija Hurme, Marko Salmi, Jukka Hytönen
BACKGROUND: Lyme neuroborreliosis (LNB) is one of the manifestations of Lyme disease. Although it is known that immune reaction of LNB patients is dominated by Th1 and Th2 responses and patients have elevated numbers of B cells in their cerebrospinal fluid (CSF), not all the cells involved in inflammation and cytokine secretion have been characterized. The current diagnostics of LNB is based on intrathecal production of antibodies. In recent years, the measurement of chemokine CXCL13 concentration from the CSF has been introduced as a new promising diagnostic tool for LNB to complement the antibody-based diagnostic methods...
October 18, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27744511/actin-dependent-regulation-of-borrelia-burgdorferi-phagocytosis-by-macrophages
#6
Xenia Naj, Stefan Linder
The spirochete Borrelia burgdorferi is the causative agent of Lyme disease, a multisystemic disorder affecting primarily skin, nervous system, and joints. If an infection with Borrelia proceeds unchecked, the disease can also enter a chronic stage, leading to the development of neuroborreliosis or cardiac arrhythmia. Successful elimination of B. burgdorferi by the host immune system is thus decisive for the positive outcome of a respective infection. Accordingly, host immune cells such as macrophages and dendritic cells have to be able to efficiently internalize and degrade infecting spirochetes...
October 16, 2016: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/27719999/epidemiology-of-lyme-neuroborreliosis
#7
David S Younger
Lyme disease is caused by the bacterium Borrelia burgdorferi and is transmitted to humans through the bite of infected blacklegged ticks. According to the Centers for Disease Control and Prevention, it is the most commonly reported vector-borne illness and the fifth most common disease in the National Notifiable Diseases Surveillance System. If left untreated, infection disseminates to the nervous system. The nonhuman primate model of Lyme disease of the nervous system, or Lyme neuroborreliosis, accurately mimics the aspects of the human illness...
November 2016: Neurologic Clinics
https://www.readbyqxmd.com/read/27714590/technical-and-clinical-validation-of-three-commercial-real-time-pcr-kits-for-the-diagnosis-of-neuroborreliosis-in-cerebrospinal-fluid-on-three-different-real-time-pcr-platforms
#8
L Maes, T Carolus, V De Preter, S Ignoul, R Cartuyvels, L Braeken, P-J D'Huys, V Saegeman, B Kabamba, M Raymaekers
This study reports the evaluation of the technical and clinical validation of the O-DiaBorburg kit (DIA), Borrelia burgdorferi PCR kit, ISEX (GENE), and Borrelia burgdorferi sensu lato Real-TM (SAC) for the diagnosis of neuroborreliosis in cerebrospinal fluid based on both Borrelia DNA and CSF samples from patients with clinical suspicion of neuroborreliosis. This validation study was done by analysing the kits on the Rotorgene Q (RGQ), CFX96, and LightCycler480 (LC480). For all kits, the linear range was larger on RGQ than on CFX96 and LC480...
October 6, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27686962/efficacy-and-safety-of-pharmacological-treatments-for-lyme-neuroborreliosis-in-children-a-systematic-review
#9
Rick Dersch, Tilman Hottenrott, Stefanie Schmidt, Harriet Sommer, Hans-Iko Huppertz, Sebastian Rauer, Joerg J Meerpohl
BACKGROUND: Many aspects of pharmacological treatment of Lyme neuroborreliosis in children, such as choice of drug, dosage, and duration are subject to intense debates, leading to uncertainties in patients' parents and healthcare providers alike. To assess the available evidence for pharmacological treatment for children with Lyme neuroborreliosis we conducted a systematic review. METHODS: The comprehensive systematic literature search included randomized-controlled trials (RCTs) and non-randomized studies (NRS) on treatment of Lyme neuroborreliosis in children (age <18 years)...
September 29, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27651242/evaluation-of-two-assays-for-cxcl13-analysis-in-cerebrospinal-fluid-for-laboratory-diagnosis-of-lyme-neuroborreliosis
#10
Anna J Henningsson, Paula Gyllemark, Malin Lager, Barbro Hedin Skogman, Ivar Tjernberg
We evaluated the diagnostic performance of two assays, one bead-based assay and one enzyme-linked immunosorbent assay (ELISA), for the determination of CXCL13 levels in cerebrospinal fluid (CSF) from patients with suspected Lyme neuroborreliosis (LNB). Patients investigated for LNB were retrospectively included (n = 132): 35 with definite LNB, 8 with possible LNB with CSF pleocytosis but normal antibody index (AI), 6 with possible LNB with elevated AI but no CSF pleocytosis and 83 non-LNB patients. CSF samples had been drawn before antibiotic treatment and were analysed for CXCL13 by Quantikine ELISA (R&D Systems) and recomBead (Mikrogen)...
November 2016: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/27618323/white-matter-diseases-with-radiologic-pathologic-correlation
#11
Nicolae Sarbu, Robert Y Shih, Robert V Jones, Iren Horkayne-Szakaly, Laura Oleaga, James G Smirniotopoulos
White matter diseases include a wide spectrum of disorders that have in common impairment of normal myelination, either by secondary destruction of previously myelinated structures (demyelinating processes) or by primary abnormalities of myelin formation (dysmyelinating processes). The pathogenesis of many white matter diseases remains poorly understood. Demyelinating disorders are the object of this review and will be further divided into autoimmune, infectious, vascular, and toxic-metabolic processes. Autoimmune processes include multiple sclerosis and related diseases: tumefactive demyelinating lesions, Balo concentric sclerosis, Marburg and Schilder variants, neuromyelitis optica (Devic disease), acute disseminated encephalomyelitis, and acute hemorrhagic leukoencephalopathy (Hurst disease)...
September 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27576284/-acute-transverse-myelitis-in-a-traveler
#12
Natalia García Allende, Mara J García Posada, Mariana F Radosta, Ana V Sánchez, Micaela Mayer Wolf, Viviana Rodríguez
Acute transverse myelitis is defined as an acquired neuroimmune disorder of the spinal cord, which occurs as a consequence of a primary event, or directly related to an autoimmune inflammatory disease, an infectious or post-infectious disease. Amongst infectious etiologies, Borrelia spp., a tick-bourne anthropozoonosis of the ixodidae family, prevails. Approximately 10 to 15% of patients with Lyme disease undergo neurologic manifestations, with an assorted and uncertain array of clinical syndromes. Transverse myelitis accounts for up to 5% of Lyme neuroborreliosis...
2016: Medicina
https://www.readbyqxmd.com/read/27538636/prospective-study-on-the-chemokine-cxcl13-in-neuroborreliosis-and-other-aseptic-neuroinfections
#13
D Pícha, L Moravcová, D Smíšková
The study evaluates the clinical significance of CXCL13 (leukocyte chemoattractant synthesized in CSF ) in Lyme neuroborreliosis (LNB) and other aseptic CNS infections. 244 patients with symptoms of neuroinfection and/or LNB were divided into groups: A - patients with LNB-positive antibodies in serum and CSF (96) or CSF only (14); B - patients with aseptic non-borrelial neuroinfections (82); C - negative controls (52). Group A was divided into A1-A4 according to pleocytosis in CSF and AIIgG positivity. The highest CSF CXCL13 concentrations (max...
September 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27533748/borrelia-miyamotoi-associated-neuroborreliosis-in-immunocompromised-person
#14
Katharina Boden, Sabine Lobenstein, Beate Hermann, Gabriele Margos, Volker Fingerle
Borrelia miyamotoi is a newly recognized human pathogen in the relapsing fever group of spirochetes. We investigated a case of B. miyamotoi infection of the central nervous system resembling B. burgdorferi-induced Lyme neuroborreliosis and determined that this emergent agent of central nervous system infection can be diagnosed with existing methods.
September 2016: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27499078/identification-of-mycobacterium-tuberculosis-in-the-cerebrospinal-fluid-of-patients-with-meningitis-using-nested-pcr
#15
Nora Rios-Sarabia, Olivia Hernández-González, Jorge González-Y-Merchand, Guadalupe Gordillo, Guillermo Vázquez-Rosales, Leopoldo Muñoz-Pérez, Javier Torres, Carmen Maldonado-Bernal
Tuberculous meningitis (TBM) is the most severe form of tuberculosis. It is caused by Mycobacterium tuberculosis (M. tuberculosis; MT) and it is very difficult to diagnose. The symptoms are similar to other infectious neurological diseases, such as neurocysticercosis, neuroborreliosis, or herpes viral infection. The aim of this study was to identify tuberculosis (TB) in cases of meningitis with clinical and laboratory evidence suggestive of TBM, and to confirm our findings with molecular tests for TB infection...
October 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27495236/are-the-current-notification-criteria-for-lyme-borreliosis-in-norway-suitable-results-of-an-evaluation-of-lyme-borreliosis-surveillance-in-norway-1995-2013
#16
Emily MacDonald, Didrik Frimann Vestrheim, Richard A White, Kirstin Konsmo, Heidi Lange, Audun Aase, Karin Nygård, Pawel Stefanoff, Ingeborg Aaberge, Line Vold
BACKGROUND: The approach to surveillance of Lyme borreliosis varies between countries, depending on the purpose of the surveillance system and the notification criteria used, which prevents direct comparison of national data. In Norway, Lyme borreliosis is notifiable to the Surveillance System for Communicable Diseases (MSIS). The current notification criteria include a combination of clinical and laboratory results for borrelia infection (excluding Erythema migrans) but there are indications that these criteria are not followed consistently by clinicians and by laboratories...
2016: BMC Public Health
https://www.readbyqxmd.com/read/27467328/improvement-of-diagnostic-approach-to-lyme-neuroborreliosis-in-children-by-using-recombinant-antigens-in-detection-of-intrathecally-produced-igm-igg
#17
L Krbková, J Bednářová, Z Čermáková
BACKGROUND: The purpose of the study was to evaluate new 3rd-generation test kits, EIA Borrelia recombinant IgM and IgG (TestLine, Brno, Czech Republic), in serum and cerebrospinal fluid (CSF) of children with Lyme neuroborreliosis. METHODS: Comparison of three tests was used: the whole-cell EIA from Borrelia garinii (EIA 1) was compared with the EIA using recombinant antigens (EIA 2) and immunoblot. In total, 364 samples of serum and CSF were examined. Eighty-six paired sera and CSF samples were evaluated in the first group of children with Lyme neuroborreliosis...
2016: Epidemiologie, Mikrobiologie, Imunologie
https://www.readbyqxmd.com/read/27356734/a-case-of-hemifacial-paresis-in-a-patient-with-lyme-neuroborreliosis-treated-with-antibiotics-in-whom-borrelia-meningitis-developed
#18
Hisao Shimizu, Koji Haratani, Masayuki Miyazaki, Yoshiaki Kakehi, Shuhei Nagami, Yuichi Katanami, Hiroki Kawabata, Nobuyuki Takahashi
A 38-year-old man visited our hospital because of hemifacial paresis that developed 2 months after being bit by a tick. We diagnosed idiopathic peripheral facial palsy and gave the patient oral prednisolone and valacyclovir. Although the symptoms completely resolved in about 2 weeks, there was a risk of Lyme neuroborreliosis. The patient therefore received doxycycline (100 mg twice daily) and amoxicillin (1,000 mg 3 times daily) for 14 days. Two months later, he had symptoms of meningitis such as headache and fever accompanied by lymphocytic cerebrospinal fluid pleocytosis...
July 28, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27348896/-lyme-disease-clinical-manifestations-and-treatment
#19
Ingo Stock
Lyme disease (Lyme borreliosis) is a systemic infectious disease that can present in a variety of clinical manifestations. The disease is caused by a group of spirochaetes--Borrelia burgdorferi sensu lato or Lyme borrelia--that are transmitted to humans by the bite of Ixodes ticks. Lyme disease is the most common arthropode-borne infectious disease in many European countries including Germany. Early localized infection is typically manifested by an erythema migrans skin lesion, in rarer cases as a borrelial lymphocytoma...
May 2016: Medizinische Monatsschrift Für Pharmazeuten
https://www.readbyqxmd.com/read/27327172/retrospective-evaluation-of-horses-diagnosed-with-neuroborreliosis-on-postmortem-examination-16-cases-2004-2015
#20
L K Johnstone, J B Engiles, H Aceto, V Buechner-Maxwell, T Divers, R Gardner, R Levine, N Scherrer, D Tewari, J Tomlinson, A L Johnson
BACKGROUND: Equine neuroborreliosis (NB), Lyme disease, is difficult to diagnose and has limited description in the literature. OBJECTIVE: Provide a detailed description of clinical signs, diagnostic, and pathologic findings of horses with NB. ANIMALS: Sixteen horses with histologically confirmed NB. METHODS: Retrospective review of medical records at the University of Pennsylvania and via an ACVIM listserv query with inclusion criteria requiring possible exposure to Borrelia burgdorferi and histologic findings consistent with previous reports of NB without evidence of other disease...
July 2016: Journal of Veterinary Internal Medicine
keyword
keyword
11535
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"