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Neuroborreliosis

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https://www.readbyqxmd.com/read/28060695/-extensive-myelitis-as-a-manifestation-of-neuroborreliosis
#1
Ana Brás, Nuno Marques, Beatriz Santiago, Anabela Matos, Fradique Moreira
Neurological manifestations of Lyme disease are reported in 3% - 12% of patients, with the most common form of presentation being meningoradiculitis. Other symptoms involving the central nervous system, such as myelitis or encephalitis, are rare (< 5 %). We report a case of a 66-year-old male, with a subacute extensive transverse myelitis, secondary to Borrelia burgdorferi infection. The patient underwent antibiotic therapy filed for neuroborreliosis with a good clinical outcome. The rareness in clinical symptoms and imaging presentation, based on a treatable infectious disease, highlights the importance of the inclusion of neuroborreliosis in the differential diagnosis of longitudinally extensive transverse myelitis...
September 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28049383/a-lyme-borreliosis-diagnosis-probability-score-no-relation-with-antibiotic-treatment-response
#2
Violeta T Briciu, Mirela Flonta, Daniel Leucuţa, Dumitru Cârstina, Doina F Ţăţulescu, Mihaela Lupşe
OBJECTIVES: (1) To describe epidemiological and clinical data of patients that present with the suspicion of Lyme borreliosis (LB); (2) to evaluate a previous published score that classifies patients on the probability of having LB, following-up patients' clinical outcome after antibiotherapy. METHODS: Inclusion criteria: patients with clinical manifestations compatible with LB and Borrelia (B.) burgdorferi positive serology, hospitalized in a Romanian hospital between January 2011 and October 2012...
January 3, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28049117/rare-cause-of-bilateral-sudden-deafness
#3
F I Vos, P Merkus, E B J van Nieuwkerk, E F Hensen
In this paper, we describe the case of a 62-year-old female with recurring episodes of sudden deafness with vertigo and facial paresis. Within a month's time, this resulted in bilateral deafness and vestibular areflexia. Erroneously, the patient was diagnosed with sudden deafness of unknown origin and subsequently with neuroborreliosis (Lyme disease). The true diagnosis of relapsing polychondritis (RP) was revealed 9 months after initial presentation. The diagnostic delay is in part explained by the fact that, by definition, the disease has to relapse before the diagnosis can be made, but also by its pluriform clinical presentation...
October 8, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/28040562/enzootic-origins-for-clinical-manifestations-of-lyme-borreliosis
#4
Setareh Jahfari, Aleksandra Krawczyk, E Claudia Coipan, Manoj Fonville, Joppe W Hovius, Hein Sprong, Katsuhisa Takumi
Both early localized and late disseminated forms of Lyme borreliosis are caused by Borrelia burgdorferi senso lato. Differentiating between the spirochetes that only cause localized skin infection from those that cause disseminated infection, and tracing the group of medically-important spirochetes to a specific vertebrate host species, are two critical issues in disease risk assessment and management. Borrelia burgdorferi senso lato isolates from Lyme borreliosis cases with distinct clinical manifestations (erythema migrans, neuroborreliosis, acrodermatitis chronica atrophicans, and Lyme arthritis) and isolates from Ixodes ricinus ticks feeding on rodents, birds and hedgehogs were typed to the genospecies level by sequencing part of the intergenic spacer region...
December 28, 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28017623/pathogenetic-implications-of-the-age-at-time-of-diagnosis-and-skin-location-for-acrodermatitis-chronica-atrophicans
#5
Katarina Ogrinc, Gary P Wormser, Paul Visintainer, Vera Maraspin, Stanka Lotrič-Furlan, Jože Cimperman, Eva Ružić-Sabljić, Petra Bogovič, Tereza Rojko, Daša Stupica, Franc Strle
BACKGROUND: The pathogenesis of acrodermatitis chronica atrophicans (ACA) is not well understood. OBJECTIVE: The purpose of this study was to gain a better understanding of ACA by utilizing a large data set of adult Slovenian patients with Lyme borreliosis. METHODS: The age of 590 ACA patients was compared with that of patients with other manifestations of Lyme borreliosis. The location of the ACA lesion on the body was compared with that of erythema migrans (EM)...
November 24, 2016: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/27931077/antibiotics-for-the-neurological-complications-of-lyme-disease
#6
REVIEW
Diego Cadavid, Paul G Auwaerter, Jeffrey Rumbaugh, Harald Gelderblom
BACKGROUND: Various central nervous system-penetrant antibiotics are bactericidal in vitro and in vivo against the causative agent of Lyme neuroborreliosis (LNB), Borrelia burgdorferi. These antibiotics are routinely used clinically to treat LNB, but their relative efficacy is not clear. OBJECTIVES: To assess the effects of antibiotics for the treatment of LNB. SEARCH METHODS: On 25 October 2016 we searched the Cochrane Neuromuscular Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, and Embase...
8, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27918952/evaluation-of-nf-%C3%AE%C2%BAb-concentration-in-patients-with-tick-borne-encephalitis-neuroborreliosis-anaplasmosis-and-anaplasma-phagocythophilum-with-tick-borne-encephalitis-virus-co-infection
#7
Anna Moniuszko-Malinowska, Piotr Czupryna, Justyna Dunaj, Renata Swierzbinska, Katarzyna Guziejko, Ryszard Rutkowski, Joanna Zajkowska, Sambor Grygorczuk, Maciej Kondrusik, Sławomir Pancewicz
OBJECTIVES: The aim of the study was the evaluation of NF-κB concentration in serum and cerebrospinal fluid (CSF) of patients with diagnosis of tick-borne diseases: tick-borne encephalitis (TBE), neuroborreliosis (NB), anaplasmosis (ANA) and patients co-infected with tick-borne encephalitis virus and Anaplasma phagocythophilum (TBE+ANA). Additionally NF-κB concentration during acute and convalescent period was compared. METHODS: Sixty-seven patients with diagnosis of tick-borne diseases were included in the study...
December 2, 2016: Cytokine
https://www.readbyqxmd.com/read/27916969/immunogenetic-markers-definition-in-latvian-patients-with-lyme-borreliosis-and-lyme-neuroborreliosis
#8
Lilija Kovalchuka, Svetlana Cvetkova, Julija Trofimova, Jelena Eglite, Sandra Gintere, Irina Lucenko, Barbara Oczko-Grzesik, Ludmila Viksna, Angelika Krumina
The aim of this study was to determine the human leukocyte antigen (HLA)-DRB1 alleles in two groups of patients in Latvia: patients with Lyme borreliosis and patients with Lyme neuroborreliosis. The study included 216 patients with Lyme borreliosis, 29 patients with Lyme neuroborreliosis and 282 control persons. All surveyed persons were residents of Latvia. The HLA-DR genotyping was performed by polymerase chain reaction- sequence specific primer (PCR-SSP). The predisposition to the Lyme borreliosis is associated with the HLA-DRB1*07, -DRB1*17(03), -DRB1*04, -DRB1*15(02) alleles...
December 1, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27885483/neuroborreliosis
#9
John J Halperin
Appropriate, critical application of evidence-based diagnostic criteria enables both a clear definition of what constitutes neuroborreliosis-nervous system infection with Borrelia burgdorferi sensu stricto in the US, B garinii and less commonly B. afzelii and other species in Europe-and recognition that this disorder is quite similar in Europe and the US. Most commonly evidenced by lymphocytic meningitis and/or multifocal inflammation of the peripheral (common; cranial neuropathy, radiculopathy, mononeuropathy multiplex) or central (rare) nervous system, it is readily diagnosed and highly antibiotic responsive...
November 24, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27847963/-challenge-of-neuroborreliosis
#10
A Spreer, S Rauer, H Wilking, V Fingerle
Lyme borreliosis is the most frequent tick-borne infection in Europe. It is a multisystemic disease affecting the skin, joints, heart, in rare cases the eyes and regularly the nervous system. Taking current clinical and microbiological guidelines into account, neuroborreliosis can in general be diagnosed and treated successfully. An appropriate guideline-conform antibiotic treatment is effective and in most cases recovery from acute neuroborreliosis is complete. Nevertheless, the evidence base regarding pharmacological treatment needs reform and improvement...
December 2016: Der Nervenarzt
https://www.readbyqxmd.com/read/27832501/phospholipidomic-analysis-reveals-changes-in-sphingomyelin-and-lysophosphatidylcholine-profiles-in-plasma-from-patients-with-neuroborreliosis
#11
W Łuczaj, P Domingues, M R Domingues, S Pancewicz, E Skrzydlewska
In recent years, the number of patients suffering from Lyme Disease (LD) has significantly increased. The most dangerous manifestation of LD is neuroborreliosis associated with invasion of the central nervous system by Borrelia burgdorferi. Phospholipids (PL) and their metabolites are involved in inflammation, which plays a dominant, but still unclear, role in the pathogenesis of neuroborreliosis. We analyzed the plasma PL profiles of neuroborreliosis patients (n = 8) and healthy volunteers (n = 8) using a lipidomic approach...
November 10, 2016: Lipids
https://www.readbyqxmd.com/read/27820708/lyme-neuroborreliosis
#12
Uwe Koedel, Hans-Walter Pfister
PURPOSE OF REVIEW: Lyme disease is a multistage and multisystem disease. Neurological manifestations [termed Lyme neuroborreliosis (LNB)] occur in about 10% of patients with Lyme disease. Diagnostics and treatment of early and late LNB are widely established. However, the management of persistent symptoms is still fraught with controversies, and therefore is the focus of this review. RECENT FINDINGS: The incidence of Lyme disease seems to be much higher than previously assumed...
February 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27756335/cerebrospinal-fluid-cytokines-in-lyme-neuroborreliosis
#13
Annukka Pietikäinen, Mikael Maksimow, Tommi Kauko, Saija Hurme, Marko Salmi, Jukka Hytönen
BACKGROUND: Lyme neuroborreliosis (LNB) is one of the manifestations of Lyme disease. Although it is known that immune reaction of LNB patients is dominated by Th1 and Th2 responses and patients have elevated numbers of B cells in their cerebrospinal fluid (CSF), not all the cells involved in inflammation and cytokine secretion have been characterized. The current diagnostics of LNB is based on intrathecal production of antibodies. In recent years, the measurement of chemokine CXCL13 concentration from the CSF has been introduced as a new promising diagnostic tool for LNB to complement the antibody-based diagnostic methods...
October 18, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27744511/actin-dependent-regulation-of-borrelia-burgdorferi-phagocytosis-by-macrophages
#14
Xenia Naj, Stefan Linder
The spirochete Borrelia burgdorferi is the causative agent of Lyme disease, a multisystemic disorder affecting primarily skin, nervous system, and joints. If an infection with Borrelia proceeds unchecked, the disease can also enter a chronic stage, leading to the development of neuroborreliosis or cardiac arrhythmia. Successful elimination of B. burgdorferi by the host immune system is thus decisive for the positive outcome of a respective infection. Accordingly, host immune cells such as macrophages and dendritic cells have to be able to efficiently internalize and degrade infecting spirochetes...
October 16, 2016: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/27719999/epidemiology-of-lyme-neuroborreliosis
#15
REVIEW
David S Younger
Lyme disease is caused by the bacterium Borrelia burgdorferi and is transmitted to humans through the bite of infected blacklegged ticks. According to the Centers for Disease Control and Prevention, it is the most commonly reported vector-borne illness and the fifth most common disease in the National Notifiable Diseases Surveillance System. If left untreated, infection disseminates to the nervous system. The nonhuman primate model of Lyme disease of the nervous system, or Lyme neuroborreliosis, accurately mimics the aspects of the human illness...
November 2016: Neurologic Clinics
https://www.readbyqxmd.com/read/27714590/technical-and-clinical-validation-of-three-commercial-real-time-pcr-kits-for-the-diagnosis-of-neuroborreliosis-in-cerebrospinal-fluid-on-three-different-real-time-pcr-platforms
#16
L Maes, T Carolus, V De Preter, S Ignoul, R Cartuyvels, L Braeken, P-J D'Huys, V Saegeman, B Kabamba, M Raymaekers
This study reports the evaluation of the technical and clinical validation of the O-DiaBorburg kit (DIA), Borrelia burgdorferi PCR kit, ISEX (GENE), and Borrelia burgdorferi sensu lato Real-TM (SAC) for the diagnosis of neuroborreliosis in cerebrospinal fluid based on both Borrelia DNA and CSF samples from patients with clinical suspicion of neuroborreliosis. This validation study was done by analysing the kits on the Rotorgene Q (RGQ), CFX96, and LightCycler480 (LC480). For all kits, the linear range was larger on RGQ than on CFX96 and LC480...
October 6, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27686962/efficacy-and-safety-of-pharmacological-treatments-for-lyme-neuroborreliosis-in-children-a-systematic-review
#17
Rick Dersch, Tilman Hottenrott, Stefanie Schmidt, Harriet Sommer, Hans-Iko Huppertz, Sebastian Rauer, Joerg J Meerpohl
BACKGROUND: Many aspects of pharmacological treatment of Lyme neuroborreliosis in children, such as choice of drug, dosage, and duration are subject to intense debates, leading to uncertainties in patients' parents and healthcare providers alike. To assess the available evidence for pharmacological treatment for children with Lyme neuroborreliosis we conducted a systematic review. METHODS: The comprehensive systematic literature search included randomized-controlled trials (RCTs) and non-randomized studies (NRS) on treatment of Lyme neuroborreliosis in children (age <18 years)...
September 29, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27651242/evaluation-of-two-assays-for-cxcl13-analysis-in-cerebrospinal-fluid-for-laboratory-diagnosis-of-lyme-neuroborreliosis
#18
Anna J Henningsson, Paula Gyllemark, Malin Lager, Barbro Hedin Skogman, Ivar Tjernberg
We evaluated the diagnostic performance of two assays, one bead-based assay and one enzyme-linked immunosorbent assay (ELISA), for the determination of CXCL13 levels in cerebrospinal fluid (CSF) from patients with suspected Lyme neuroborreliosis (LNB). Patients investigated for LNB were retrospectively included (n = 132): 35 with definite LNB, 8 with possible LNB with CSF pleocytosis but normal antibody index (AI), 6 with possible LNB with elevated AI but no CSF pleocytosis and 83 non-LNB patients. CSF samples had been drawn before antibiotic treatment and were analysed for CXCL13 by Quantikine ELISA (R&D Systems) and recomBead (Mikrogen)...
November 2016: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/27618323/white-matter-diseases-with-radiologic-pathologic-correlation
#19
Nicolae Sarbu, Robert Y Shih, Robert V Jones, Iren Horkayne-Szakaly, Laura Oleaga, James G Smirniotopoulos
White matter diseases include a wide spectrum of disorders that have in common impairment of normal myelination, either by secondary destruction of previously myelinated structures (demyelinating processes) or by primary abnormalities of myelin formation (dysmyelinating processes). The pathogenesis of many white matter diseases remains poorly understood. Demyelinating disorders are the object of this review and will be further divided into autoimmune, infectious, vascular, and toxic-metabolic processes. Autoimmune processes include multiple sclerosis and related diseases: tumefactive demyelinating lesions, Balo concentric sclerosis, Marburg and Schilder variants, neuromyelitis optica (Devic disease), acute disseminated encephalomyelitis, and acute hemorrhagic leukoencephalopathy (Hurst disease)...
September 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27576284/-acute-transverse-myelitis-in-a-traveler
#20
Natalia García Allende, Mara J García Posada, Mariana F Radosta, Ana V Sánchez, Micaela Mayer Wolf, Viviana Rodríguez
Acute transverse myelitis is defined as an acquired neuroimmune disorder of the spinal cord, which occurs as a consequence of a primary event, or directly related to an autoimmune inflammatory disease, an infectious or post-infectious disease. Amongst infectious etiologies, Borrelia spp., a tick-bourne anthropozoonosis of the ixodidae family, prevails. Approximately 10 to 15% of patients with Lyme disease undergo neurologic manifestations, with an assorted and uncertain array of clinical syndromes. Transverse myelitis accounts for up to 5% of Lyme neuroborreliosis...
2016: Medicina
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