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Neuroborreliosis

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https://www.readbyqxmd.com/read/29748118/diaphragmatic-dysfunction-as-the-presenting-symptom-in-neuromuscular-disorders-a-retrospective-longitudinal-study-of-etiology-and-outcome-in-30-german-patients
#1
Matthias Türk, Irina Weber, Gernot Vogt-Ladner, Rolf Schröder, Martin Winterholler
Diaphragmatic dysfunction is well-known in advanced stages of neuromuscular disorders. However, data on its presence as the presenting symptom in neuromuscular disorders is scarce. The goal of this retrospective longitudinal study was to evaluate the etiology and clinical outcome in patients, in whom uni- or bilateral diaphragmatic dysfunction was primarily diagnosed, before a specific neuromuscular disease was found. Patients with critical illness neuropathy/myopathy were excluded from this study. Analysis of the medical records of two tertiary referral centers for patients with neuromuscular diseases identified 30 corresponding patients with diaphragmatic dysfunction (17 unilateral; 13 bilateral)...
April 9, 2018: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29744083/autonomous-dysfunction-in-lyme-neuroborreliosis-a-case-report
#2
Bent-Are Hansen, Torgeir Finjord, Øyvind Bruserud
The diagnosis of Lyme neuroborreliosis should be considered whenever a patient presents with neurological symptoms and comes from an endemic area. However, atypical clinical presentation occurs including gastrointestinal manifestations because of autonomous dysfunction.
May 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29705691/cxcl13-concentrations-in-cerebrospinal-fluid-of-patients-with-lyme-neuroborreliosis-and-other-neurological-disorders-determined-by-luminex-and-elisa
#3
Mateusz Markowicz, Anna-Margarita Schötta, Michael Kundi, Petra Bogovič, Katarina Ogrinc, Franc Strle, Gerold Stanek
The aims of the study were to determine and compare the concentration of CXCL13 in cerebrospinal fluid (CSF) of patients with Lyme neuroborreliosis (LNB) and various other neurological disorders applying a Luminex based assay and ELISA, and to find factors associated with CXCL13 concentration. CSF samples obtained from four clinically well-defined groups of patients (proven LNB, suspected LNB, tick-borne encephalitis (TBE), and aseptic meningitis/meningoencephalitis other than TBE) - 25 samples per group - were analyzed...
April 20, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29674128/diagnostic-value-of-cerebrospinal-fluid-cxcl13-for-acute-lyme-neuroborreliosis-a-systemic-review-and-meta-analysis
#4
REVIEW
Tobias Armin Rupprecht, Kirsi Marjaana Manz, Volker Fingerle, Christian Lechner, Matthias Klein, Markus Pfirrmann, Uwe Koedel
OBJECTIVES: The utility of cerebrospinal fluid (CSF) CXCL13 for diagnosis of acute Lyme neuroborreliosis (LNB) has been debated and the test is not yet routinely performed. This study's aim was to evaluate its overall diagnostic accuracy through meta-analysis. METHODS: Electronic searches in PubMed MEDLINE and Web of Science were performed to identify relevant articles published before January 2018. A summary receiver operating characteristic curve and an optimal cut-off were estimated modeling multiple cut-offs...
April 16, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29648995/cerebrospinal-fluid-free-light-chains-as-diagnostic-biomarker-in-neuroborreliosis
#5
Harald Hegen, Dejan Milosavljevic, Christine Schnabl, Andrea Manowiecka, Janette Walde, Florian Deisenhammer, Stefan Presslauer
BACKGROUND: Free light chains (FLC) have been proposed as diagnostic biomarker in patients with inflammatory central nervous system diseases. The objective of this study was to investigate the diagnostic utility of intrathecal κ- and λ-FLC synthesis in patients with neuroborreliosis. METHODS: κ- and λ-FLC were measured by nephelometry under blinded conditions in cerebrospinal fluid (CSF) and serum sample pairs of 34 patients with neuroborreliosis and compared to a cohort of 420 control patients...
April 12, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29628177/cerebrospinal-fluid-monocytes-in-bacterial-meningitis-viral-meningitis-and-neuroborreliosis
#6
M Martinot, V Greigert, L Souply, B Rosolen, D De Briel, M Mohseni Zadeh, J-D Kaiser
OBJECTIVE: Cerebrospinal fluid (CSF) leukocytes analysis is commonly used to diagnose meningitis and to differentiate bacterial from viral meningitis. Interpreting CSF monocytes can be difficult for physicians, especially in France where lymphocytes and monocytes results are sometimes pooled. PATIENTS AND METHODS: We assessed SF monocytes in patients presenting with microbiologically confirmed meningitis (CSF leukocyte count>10/mm3 for adults or >30/mm3 for children<2 months), i...
April 5, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29602888/pseudotumor-cerebri-as-the-presentation-of-lyme-disease-in-a-non-endemic-area
#7
Marta Ezequiel, Ana Teresa Teixeira, Maria João Brito, Catarina Luís
Intracranial hypertension is a rare entity in prepubertal children, and its differential diagnosis includes a number of systemic diseases, drugs, vitamin deficiencies and excesses, and hereditary conditions. Infectious aetiology is rare. The case of a 9-year-old boy with intracranial hypertension secondary to acute neuroborreliosis is described. He presented with daily pulsatile frontotemporal headache, pallor, photophobia and phonophobia. His neurological examination revealed papilledema with no nuchal rigidity...
March 30, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29600690/occurrence-of-lyme-disease-infection-in-a-non-endemic-area-in-northern-italy
#8
Sara G Rimoldi, Stefania Merli, Giovanna Bestetti, Vania Giacomet, Giuliana Cislaghi, Romualdo Grande, Sergio Sanzani, Cristina Pagani, Giusto Trevisan, Eleonora DE Faveri, Maria R Gismondo, Eva Ruzić-Sabljić
BACKGROUND: In Italy, the incidence of human tick borne disease has increased over the last decades. Since 2015 a multidisciplinary group has been established in Sacco Hospital for the management of the patients affected by Lyme Disease (LD). A retrospective evaluation (2015-2017) was performed for LD in non-endemic areas. METHODS: Retrospective analysis of all 1000 samples for 800 patients screened for LD antibodies at the Sacco Hospital in 3 years (2015-2017)...
March 29, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29567125/point-of-care-testing-for-cxcl13-in-lyme-neuroborreliosis
#9
Annukka Pietikäinen, Jarmo Oksi, Jukka Hytönen
Cerebrospinal fluid chemokine (C-X-C motif) ligand 13 (CXCL13) is a marker for Lyme neuroborreliosis (LNB). CXCL13 lateral flow immunoassay (LFA) was compared with CXCL13 ELISA. CXCL13 LFA results correlated strongly with CXCL13 ELISA results. CXCL13 LFA is a rapid and easy-to-perform test, which is suitable for routine point-of-care diagnostics of suspected LNB patients.
February 23, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29559369/assessment-of-hmgb-1-concentration-in-tick-borne-encephalitis-and-neuroborreliosis
#10
Anna Moniuszko-Malinowska, Paweł Penza, Piotr Czupryna, Olga Zajkowska, Sławomir Pancewicz, Renata Świerzbińska, Justyna Dunaj, Joanna Zajkowska
BACKGROUND: The aim of this study was to determine the concentration of HMGB-1 (high mobility group box 1) in the serum and cerebrospinal fluid (CSF) of patients suffering from tick-borne encephalitis (TBE) and neuroborreliosis (NB). Focus was placed on HMGB-1 measurement in the CSF or serum in order to establish whether this could help to differentiate between NB and TBE. METHODS: Eighty patients with meningitis and meningoencephalitis were enrolled in the study...
March 17, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29502989/subclinical-lyme-borreliosis-is-common-in-south-eastern-sweden-and-may-be-distinguished-from-lyme-neuroborreliosis-by-sex-age-and-specific-immune-marker-patterns
#11
Hanna Carlsson, Christina Ekerfelt, Anna J Henningsson, Lars Brudin, Ivar Tjernberg
BACKGROUND: Determinants of a subclinical course of Lyme borreliosis (LB) remain largely unknown. The aim of this study was to assess the extent, sex and age profiles of subclinical Borrelia seroconversion in a LB endemic area in Sweden and to map blood cellular Borrelia-specific immune marker patterns in individuals with a previous subclinical LB course compared with patients previously diagnosed with Lyme neuroborreliosis (LNB). METHODS: A large group of 1113 healthy blood donors was screened for multiple IgG anti-Borrelia antibodies and asked to complete a health inquiry regarding previous LB...
March 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29485697/cerebrospinal-fluid-%C3%AE-%C3%AE-t-cell-frequency-is-age-related-a-case-control-study-of-435-children-with-inflammatory-and-non-inflammatory-neurological-disorders
#12
M R Pranzatelli, T J Allison, N R McGee, E D Tate
Studies of cerebrospinal fluid (CSF) γδ T cells in children are limited, due especially to the lack of control data. In adults, gamma/delta T cells (TCR-γδ) residing in the intrathecal space are sometimes involved in neuroinflammation. To evaluate the possible role of γδ T cells in paediatric neuroinflammation, we immunophenotyped cerebrospinal fluid (CSF) and blood lymphocytes using flow cytometry in a case-control study of 100 children with non-inflammatory neurological disorders (NIND), 312 with opsoclonus-myoclonus (OMS) and 23 with other inflammatory neurological disorders (OIND)...
February 27, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29479908/acoustic-reflex-and-house-brackmann-rating-scale-as-prognostic-indicators-of-peripheral-facial-palsy-in-neuroborreliosis
#13
Alen Sekelj, Davorin Đanić
Lyme borreliosis is a vector-borne infectious disease characterized by three disease stages. In the areas endemic for borreliosis, every acute facial palsy indicates serologic testing and implies specific approach to the disease. Th e aim of the study was to identify and confirm the value of acoustic refl ex and House-Brackman (HB) grading scale as prognostic indicators of facial palsy in neuroborreliosis. Th e study included 176 patients with acute facial palsy divided into three groups based on serologic testing: borreliosis, Bell's palsy, and facial palsy caused by herpes simplex virus type 1 (HSV-1)...
September 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29469222/borrelia-burgdorferi-infection-and-lyme-disease-in-north-american-horses-a-consensus-statement
#14
T J Divers, R B Gardner, J E Madigan, S G Witonsky, J J Bertone, E L Swinebroad, S E Schutzer, A L Johnson
Borrelia burgdorferi infection is common in horses living in Lyme endemic areas and the geographic range for exposure is increasing. Morbidity after B. burgdorferi infection in horses is unknown. Documented, naturally occurring syndromes attributed to B. burgdorferi infection in horses include neuroborreliosis, uveitis, and cutaneous pseudolymphoma. Although other clinical signs such as lameness and stiffness are reported in horses, these are often not well documented. Diagnosis of Lyme disease is based on exposure to B...
March 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29467195/direct-molecular-detection-and-genotyping-of-borrelia-burgdorferi-sensu-lato-in-cerebrospinal-fluid-of-children-with-lyme-neuroborreliosis
#15
Bjørn Barstad, Hanne Quarsten, Dag Tveitnes, Sølvi Noraas, Ingvild S Ask, Maryam Saeed, Franziskus Bosse, Grete Vigemyr, Ilka Huber, Knut Øymar
The current diagnostic marker of Lyme neuroborreliosis (LNB), the Borrelia burgdorferi sensu lato antibody index (AI) in the cerebrospinal fluid (CSF), has insufficient sensitivity in the early phase of LNB. We aimed to elucidate the diagnostic value of PCR for B. burgdorferi sensu lato in CSF from children with symptoms suggestive of LNB and to explore B. burgdorferi sensu lato genotypes associated with LNB in children. Children were prospectively included in predefined groups with a high or low likelihood of LNB based on diagnostic guidelines (LNB symptoms, CSF pleocytosis, and B...
May 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29460492/cerebrospinal-fluid-lyme-multiplex-assay-results-are-not-diagnostic-in-horses-with-neuroborreliosis
#16
Amy L Johnson, Laura K Johnstone, Darko Stefanovski
BACKGROUND: The accuracy of the Lyme multiplex assay for the diagnosis of neuroborreliosis in horses is unknown. HYPOTHESIS/OBJECTIVES: To describe Lyme multiplex results in horses with a postmortem diagnosis of neuroborreliosis. The hypothesis was that paired serum and cerebrospinal fluid (CSF) results and a CSF : serum ratio would allow differentiation of horses with neuroborreliosis from those with other neurologic diseases. ANIMALS: Ninety horses that had neurologic examinations, serum and CSF Lyme multiplex analyses, and postmortem examination of the nervous system performed...
March 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29408631/intracellular-tlr7-is-activated-in-human-oligodendrocytes-in-response-to-borrelia-burgdorferi-exposure
#17
Geetha Parthasarathy, Mario T Philipp
Lyme neuroborreliosis, caused by the gram-negative bacterium Borrelia burgdorferi, may affect the central and/or peripheral nervous systems. In previous studies, we showed that human oligodendrocytes exposed to the bacteria undergo apoptosis in an inflammatory environment, and that inflammatory pathways trigger cell-death pathways. We further demonstrated that several receptor tyrosine kinases were involved in triggering downstream effects, leading to inflammation and apoptosis. Toll-like receptors TLR2 and TLR5, which are commonly studied receptors in Lyme disease, only had a minimal role in inflammatory processes...
April 3, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29393443/nf%C3%A2-%C3%AE%C2%BAb-is-a-key-modulator-in-the-signaling-pathway-of-borrelia-burgdorferi-bmpa%C3%A2-induced-inflammatory-chemokines-in-murine-microglia-bv2-cells
#18
Zhenyu Zhao, Lvyan Tao, Aihua Liu, Mingbiao Ma, Haiyi Li, Hua Zhao, Jiaru Yang, Shiming Wang, Yirong Jin, Xian Shao, Fukai Bao
Lyme disease, caused by the bacterial spirochete Borrelia burgdorferi, is a tick‑borne zoonosis. Lyme neuroborreliosis is a principal manifestation of Lyme disease and its pathogenesis remains incompletely understood. Recent studies have demonstrated that Borrelia burgdorferi lipoproteins caused similar inflammatory effects as exhibited in Lyme neuroborreliosis. Basic membrane protein A (BmpA) is one of the dominant lipoproteins in the Borrelia burgdorferi membrane. In addition, nuclear factor κ‑B (NF‑κB) modulates the regulation of gene transcription associated with immunity and inflammation; however, in unstimulated cells, NF‑κB is combined with the inhibitor of NF‑κB (IκB‑β)...
April 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29386499/-a-case-of-lyme-neuroborreliosis-without-erythema-migrans
#19
Katsuki Eguchi, Kazuhumi Tsuzaka, Ichiro Yabe, Hidenao Sasaki
A 56-year-old man was sustained ticks at the left axilla and flank. He did not have a rash. About 3 months after the tick bites, he developed back pain, right leg weakness, right abducens nerve palsy, and left facial palsy. Western blot analysis for serum IgM and IgG antibodies against Borrelia were positive. We diagnosed Lyme borreliosis. The patient was treated with antibiotics and steroids, and the symptoms improved. Our findings demonstrate that, even if erythema migrans is not obvious, neuroborreliosis should be considered when neurological signs, such as multiple cranial nerve palsies, are present...
February 28, 2018: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29367377/cranial-neuropathy-and-severe-pain-due-to-early-disseminated-borrelia-burgdorferi-infection
#20
Derek Ebner, Kelsey Smith, Daniel DeSimone, Muhammad Rizwan Sohail
A 61-year-old man presented to the emergency department in the summer with a right seventh cranial nerve lower motor neuron palsy and worsening paraesthesias for 6 weeks. He had debilitating pain at the scalp and spine. Prior work up was unrevealing. The patient resided in the upper Midwest region of the USA and worked outdoors, optimising the landscape for white tailed deer. Repeat cerebrospinal fluid testing revealed a lymphocytic pleocytosis and positive IgM Lyme serology. Brain MRI demonstrated enhancement of multiple cranial nerves bilaterally...
January 23, 2018: BMJ Case Reports
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