Serena Palmeri, Federica Penco, Arinna Bertoni, Marta Bustaffa, Caterina Matucci-Cerinic, Riccardo Papa, Enrico Drago, Roberta Caorsi, Anna Corcione, Paola Bocca, Cristina Scarone, Anna Rubartelli, Stefano Volpi, Marco Gattorno, Ignazia Prigione
Syndrome of undifferentiated recurrent fever (SURF) is characterized by recurrent fevers, a lack of confirmed molecular diagnosis, and a complete or partial response to colchicine. Despite the clinical similarities to familial Mediterranean fever (FMF), the underlying inflammatory mechanisms of SURF are not yet understood. We here analyzed the in vitro activation of the pyrin inflammasome in a cohort of SURF patients compared to FMF and PFAPA patients. Peripheral blood mononuclear cells (PBMC) were collected from SURF (both colchicine-treated and untreated), FMF, PFAPA patients, and healthy donors...
January 17, 2024: Journal of Clinical Immunology