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elderly randomized sleep

Jennifer L Schroeck, James Ford, Erin L Conway, Kari E Kurtzhalts, Megan E Gee, Krista A Vollmer, Kari A Mergenhagen
PURPOSE: Insomnia is problematic for older adults. After behavioral modifications fail to show adequate response, pharmacologic options are used. The pharmacokinetics of agents used to treat insomnia may be altered. This review focuses on the safety and efficacy of medications used to treat insomnia. METHODS: A literature search of Medline, PubMed, and Embase was conducted (January 1966-June 2016). It included systematic reviews, randomized controlled trials, observational studies, and case series that had an emphasis on insomnia in an older population...
October 14, 2016: Clinical Therapeutics
Thomas Roth, Jed Black, Raymond Cluydts, Pascal Charef, Marzia Cavallaro, Fabrice Kramer, Gary Zammit, James Walsh
OBJECTIVE: Sleep laboratory study to determine the dose-related efficacy and safety of almorexant in elderly patients with primary chronic insomnia. METHODS: Patients aged ≥65 years with primary insomnia were enrolled into a prospective, randomized, double-blind, placebo-controlled, multicenter dose-finding study with a five-period, five-way Latin square cross-over design. Patients were randomized to one of 10 unique sequences of two-night treatment with oral almorexant 25, 50, 100, or 200 mg capsules, or matching placebo...
October 10, 2016: Sleep
Aileen Wk Chan, Doris Sf Yu, K C Choi, Diana Tf Lee, Janet Wh Sit, Helen Yl Chan
PURPOSE: Age-related cognitivee decline is a growing public health concern worldwide. More than a quarter of adults with cognitive impairment experience sleep disturbance. The objective of this pilot study was to evaluate the preliminary effects of tai chi qigong (TCQ) on improving the night-time sleep quality of older adults with cognitive impairment. PARTICIPANTS: Older adults with cognitive impairment who complain of sleep disturbance. METHODS: A randomized controlled trial with two groups...
2016: Clinical Interventions in Aging
Xin-Hai Wu, Fan Cui, Cheng Zhang, Zhao-Ting Meng, Dong-Xin Wang, Jing Ma, Guang-Fa Wang, Sai-Nan Zhu, Daqing Ma
BACKGROUND: Patients admitted to the intensive care unit (ICU) after surgery often develop sleep disturbances. The authors tested the hypothesis that low-dose dexmedetomidine infusion could improve sleep architecture in nonmechanically ventilated elderly patients in the ICU after surgery. METHODS: This was a pilot, randomized controlled trial. Seventy-six patients age 65 yr or older who were admitted to the ICU after noncardiac surgery and did not require mechanical ventilation were randomized to receive dexmedetomidine (continuous infusion at a rate of 0...
November 2016: Anesthesiology
Iara Guimarães Rodrigues, Marilisa Berti de Azevedo Barros
INTRODUCTION: Osteoporosis is a multifactorial disease that predisposes individuals to suffer falls and fractures, causing functional impairment and a consequent reduction in quality of life. OBJECTIVE: To assess the prevalence and factors associated with self-reported osteoporosis in the elderly population living in Campinas, São Paulo, Brazil (ISACAMP 2008). METHODS: Cross-sectional study with a random sample taken by conglomerates in 2 stages totaling 1,419 elderly people living in the urban area...
April 2016: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
W Joseph Herring, Kathleen M Connor, Ellen Snyder, Duane B Snavely, Ying Zhang, Jill Hutzelmann, Deborah Matzura-Wolfe, Ruth M Benca, Andrew D Krystal, James K Walsh, Christopher Lines, Thomas Roth, David Michelson
STUDY OBJECTIVES: Suvorexant is an orexin receptor antagonist approved for treating insomnia at a maximum dose of 20 mg. Phase-3 trials evaluated two age-adjusted (non-elderly/elderly) dose-regimes of 40/30 mg and 20/15 mg with the primary focus on 40/30 mg. We report here results from pooled analyses of the 20/15 mg dose-regime, which was evaluated as a secondary objective in the trials. METHODS: Prespecified analysis of pooled data from two identical randomized, double-blind, placebo-controlled, parallel-group, 3-month trials in non-elderly (18-64 years) and elderly (≥ 65 years) patients with insomnia...
2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
Norihisa Tamura, Hideki Tanaka
Subjective insufficient sleep and delayed sleep-wake patterns have been reported as the primary causes for daytime sleepiness, a reasonably significant and prevalent problem for adolescents worldwide. Systematic reviews have indicated that the success of sleep education programs has thus far been inconsistent, due to the lack of a tailored approach that allows for evaluation of individual differences in behavior patterns. One way to resolve this problem is to assess the individual sleep behaviors of adolescents by using a checklist containing the recommended behaviors for promoting sleep health...
2016: Chronobiology International
Yi Su, Weiwei Xu, Xiangyun Wang, Zhili Zhang, Yingchun Cao, Qiuhong Yu, Jiandong Li
OBJECTIVE: To survey the prevalence of obstructive sleep apnea-hypopnea syndrome(OSAHS) in adults aged over 60 years in Dongying city,and analyze the risk factors and the extent of damage to the quality of life for the elderly to provide the basis for prevention and treatment of OSAHS people. METHOD: One thousand subjects were derived from a random cluster sampling in seven districts of Dongying city:they were asked to answer the questions from questionnaires. According to the questionnaire scoring, 100 subjects in high-risk group were selected randomly to make polysomnography monitoring for a whole night,so that the prevalence of the disease was calculated and the related risk factors were analyzed; elderly patients diagnosed with OSAHS were asked to assess the quality of life assessment questionnaire by face to face to understand the quality of life dimensions injury...
February 2016: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Sean A Martin, Sarah L Appleton, Robert J Adams, Anne W Taylor, Peter G Catcheside, Andrew Vakulin, R Douglas McEvoy, Nick A Antic, Gary A Wittert
OBJECTIVES: To examine the influence of obstructive sleep apnea (OSA) on nocturia, controlling for their shared co-morbidities, in a population of community-based middle aged to elderly men. METHODS: Participants were drawn from a randomly-selected, community-dwelling cohort of men in Adelaide, Australia. 708 men (mean:60.7 [41.6-88.2] years) who had PSG recordings, complete LUTS measures (IPSS), without prostate or bladder cancer and/or surgery, and no prior OSA diagnosis were selected...
June 24, 2016: Urology
Qun Wang, Sek Ying Chair, Eliza Mi Ling Wong, Xiaomei Li
OBJECTIVES: To examine the effects of music intervention on sleep quality in community-dwelling elderly people. DESIGN: Two-armed randomized controlled trial. SETTINGS: Four urban communities in Xi`an, China. PARTICIPANTS: People aged 60 years or older with poor sleep quality (Pittsburgh Sleep Quality Index [PSQI] score >7). INTERVENTIONS: All participants received one sleep hygiene education session and biweekly telephone calls...
July 2016: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Ellen Snyder, Junshui Ma, Vladimir Svetnik, Kathryn M Connor, Christopher Lines, David Michelson, W Joseph Herring
BACKGROUND: The orexin receptor antagonist, suvorexant, is approved for treating insomnia at a maximum dose of 20 mg. We evaluated its effects on sleep architecture. METHODS: The analyses included pooled polysomnography data from two similar randomized, double-blind, placebo-controlled, 3-month trials evaluating two age-adjusted (non-elderly/elderly) dose regimes of 20/15 mg and 40/30 mg in 1482 patients with insomnia. Polysomnography was recorded at baseline and on three nights during the treatment: Night-1, Month-1, and Month-3...
March 2016: Sleep Medicine
Nancy A Kerner, Steven P Roose
Obstructive sleep apnea (OSA) is highly prevalent but very frequently undiagnosed. OSA is an independent risk factor for depression and cognitive impairment/dementia. Herein the authors review studies in the literature pertinent to the effects of OSA on the cerebral microvascular and neurovascular systems and present a model to describe the key pathophysiologic mechanisms that may underlie the associations, including hypoperfusion, endothelial dysfunction, and neuroinflammation. Intermittent hypoxia plays a critical role in initiating and amplifying these pathologic processes...
June 2016: American Journal of Geriatric Psychiatry
Katie Moraes de Almondes, Mônica Vieira Costa, Leandro Fernandes Malloy-Diniz, Breno Satler Diniz
There are cross-sectional evidences of an association between sleep disorders and cognitive impairment on older adults. However, there are no consensus by means of longitudinal studies data on the increased risk of developing dementia related to insomnia. We conduct a systematic review and meta-analysis to evaluate the risk of incident all-cause dementia in individuals with insomnia in population-based prospective cohort studies. Five studies of 5.242 retrieved references were included in the meta-analysis...
June 2016: Journal of Psychiatric Research
Kaori Iimura, Nobuhiro Watanabe, Koichi Masunaga, Shogo Miyazaki, Harumi Hotta, Hunkyung Kim, Tatsuya Hisajima, Hidenori Takahashi, Yutaka Kasuya
BACKGROUND: Somatic afferent nerve stimuli are used for treating an overactive bladder (OAB), a major cause of nocturia in the elderly. Clinical evidence for this treatment is insufficient because of the lack of appropriate control stimuli. Recent studies on anesthetized animals show that gentle stimuli applied to perineal skin with a roller could inhibit micturition contractions depending on the roller's surface material. We examined the efficacy of gentle skin stimuli for treating nocturia...
2016: PloS One
Luis San, Belen Arranz
BACKGROUND: Mirtazapine is an antidepressant first approved in the Netherlands in 1994 for the treatment of major depressive disorder. However, evidence suggests its effectiveness in a variety of other psychiatric disorders and non-psychiatric medical conditions. OBJECTIVE: The present paper reviews the published literature on the off-label indications of Mirtazapine. METHODS: A search of the relevant literature from MEDLINE, PsycLIT and EMBASE databases, included in the Science Citation Index and available up to March 2006, was conducted using the terms mirtazapine, case-reports, open-label trials and randomized controlled trials...
June 2006: Acta Neuropsychiatrica
Valerie A Paz-Soldan, Karin Bauer, Amy C Morrison, Jhonny J Cordova Lopez, Kiyohiko Izumi, Thomas W Scott, John P Elder, Neal Alexander, Eric S Halsey, Philip J McCall, Audrey Lenhart
Dengue is an arthropod-borne virus of great public health importance, and control of its mosquito vectors is currently the only available method for prevention. Previous research has suggested that insecticide treated curtains (ITCs) can lower dengue vector infestations in houses. This observational study investigated individual and household-level socio-demographic factors associated with correct and consistent use of ITCs in Iquitos, Peru. A baseline knowledge, attitudes, and practices (KAP) survey was administered to 1,333 study participants, and ITCs were then distributed to 593 households as part of a cluster-randomized trial...
March 2016: PLoS Neglected Tropical Diseases
Trygve Müller Jonassen, Tomas Mikal Eagan, Bjørn Bjorvatn, Sverre Lehmann
OBJECTIVES: To examine the prevalence of self-reported symptoms of obstructive sleep apnoea (OSA) in relation to asthma, respiratory symptoms, and pulmonary function. A secondary objective was to determine how sex impacted these relationships. METHODS: A random sample of all adults aged 47-48 and 71-73 years living in Bergen, Norway, were invited. Participants (3506, 69%) underwent spirometry testing and completed a questionnaire on sleep, respiratory symptoms, and past medical history...
March 7, 2016: Clinical Respiratory Journal
Wen-fei Tan, Er-ya Miao, Feng Jin, Hong Ma, Huang-wei Lu
BACKGROUND AND OBJECTIVES: Supplementation of spinal anesthesia with various sedatives is a standard protocol to alleviate patient anxiety associated with the surgical procedure. We hypothesized that, compared with dexmedetomidine, midazolam might have a subtle influence on sleep quality after surgery following elective transurethral prostatic resection (TURP) in elderly male patients. METHODS: A randomized, double-blind, controlled trial was conducted at the First Hospital of China Medical University from July 2014 to January 2015...
May 2016: Regional Anesthesia and Pain Medicine
Andressa Alves da Silva, Renato Gorga Bandeira de Mello, Camila Wohlgemuth Schaan, Flávio D Fuchs, Susan Redline, Sandra C Fuchs
OBJECTIVE: The purpose of our study was to evaluate the association between short and long sleep duration and all-cause and cardiovascular mortality among elderly individuals. DESIGN: Systematic review and meta-analysis of population-based cohort studies. SETTING: Articles were retrieved from international and national electronic databases. STUDY SELECTION: Studies were identified in PubMed, EMBASE, LILACS (Latin American and Caribbean Health Sciences Literature), IBECS (Bibliographic Index on Health Sciences from Spain) and CAPES (PhD thesis repository) between 1980 and 2015...
2016: BMJ Open
Victor Ancuelle, Rodrigo Zamudio, Andrea Mendiola, Daniel Guillen, Pedro J Ortiz, Tania Tello, Darwin Vizcarra
We aimed to evaluate the impact in sleep quality and musculoskeletal pain of a Medium-Firm Mattress (MFM), and their relationship with objective sleep parameters in a group of institutionalized elders. The sample size included forty older adults with musculoskeletal pain. We did a clinical assessment at baseline and weekly trough the study period of four weeks. We employed the Pittsburgh Sleep Quality Index (PSQI) and Pain Visual Analog Scale (P-VAS). Additionally a sub-group of good sleepers, selected from PSQI baseline evaluation, were studied with actigraphy and randomized to MFM or High Firm Mattress (HFM), in two consecutive nights...
November 2015: Sleep Science
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