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Centella-asiatica

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https://www.readbyqxmd.com/read/29460197/anti-inflammatory-effect-of-asiaticoside-on-human-umbilical-vein-endothelial-cells-induced-by-ox-ldl
#1
Li Jing, Wang Haitao, Wang Qiong, Zhu Fu, Zhang Nan, Zhang Xuezheng
Early diagnosis and changes associated with atherosclerosis are crucial in clinical medicine. However, atherosclerosis is a multifactorial disease. Asiaticoside (AA), a triterpenoid derived from Centella asiatica, has anti-inflammatory activity. Endothelium-derived nitric oxide is important in modulating vascular tone in a distinct vessel size-dependent manner; it plays a dominant role in conduit arteries and endothelium-dependent hyperpolarisation in resistance vessels. This study evaluated the effects of AA administration on human umbilical endothelial cells with oxidised low-density lipoprotein-induced inflammation...
February 19, 2018: Cytotechnology
https://www.readbyqxmd.com/read/29438895/piriformospora-indica-cell-wall-extract-as-the-best-elicitor-for-asiaticoside-production-in-centella-asiatica-l-urban-evidenced-by-morphological-physiological-and-molecular-analyses
#2
S Jisha, P R Gouri, K N Anith, K K Sabu
Vascular plants synthesise a multitude of organic molecules or phytochemicals, referred to as "secondary metabolites". These molecules are involved in a variety of roles in the life span of plants, ranging from structural ones to protection. Centella asiatica (L.) Urban has probably been used since prehistoric times and has been reported to have been used for various medicinal and cosmetic purposes. The plant contains several active constituents, of which the most important is asiaticoside, a triterpenoid. Asiaticoside content in C...
February 7, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29436598/madecassoside-activates-anti%C3%A2-neuroinflammatory-mechanisms-by-inhibiting-lipopolysaccharide%C3%A2-induced-microglial-inflammation
#3
Andrew Octavian Sasmita, Anna Pick Kiong Ling, Kenny Gah Leong Voon, Rhun Yian Koh, Ying Pei Wong
Neurodegeneration is typically preceded by neuroinflammation generated by the nervous system to protect itself from tissue damage, however, excess neuroinflammation may inadvertently cause more harm to the surrounding tissues. Attenuating neuroinflammation with non‑steroidal anti‑inflammatory drugs can inhibit neurodegeneration. However, such treatments induce chronic side effects, including stomach ulcers. Madecassoside, a triterpene derived from Centella asiatica, is considered to be an alternative treatment of inflammation...
February 9, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29373997/indigenous-uses-of-ethnomedicinal-plants-among-forest-dependent-communities-of-northern-bengal-india
#4
Antony Joseph Raj, Saroj Biswakarma, Nazir A Pala, Gopal Shukla, Vineeta, Munesh Kumar, Sumit Chakravarty, Rainer W Bussmann
BACKGROUND: Traditional knowledge on ethnomedicinal plant is slowly eroding. The exploration, identification and documentation on utilization of ethnobotanic resources are essential for restoration and preservation of ethnomedicinal knowledge about the plants and conservation of these species for greater interest of human society. METHODS: The study was conducted at fringe areas of Chilapatta Reserve Forest in the foothills of the eastern sub-Himalayan mountain belts of West Bengal, India, from December 2014 to May 2016...
January 26, 2018: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29369796/asiatic-acid-inhibits-lps-induced-inflammatory-response-in-endometrial-epithelial-cells
#5
Shou-Yan Cao, Wei Wang, Fang-Fang Nan, Yan-Ni Liu, Shuang-Yan Wei, Fang-Fang Li, Li Chen
Accumulating evidence indicates that asiatic acid, a natural triterpene isolated from Centella asiatica, has anti-inflammatory activity. However, the anti-inflammatory effects of asiatic acid on LPS-stimulated endometrial epithelial cells and the involved molecular pathways have not been completely elucidated. In the present study, we evaluated the effects of asiatic acid on LPS-induced inflammatory response in endometrial epithelial cells. Mouse endometrial epithelial cells were treated with asiatic acid and stimulated with LPS...
January 21, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29361877/pharmacological-review-on-asiatic-acid-and-its-derivatives-a-potential-compound
#6
Junwei Lv, Alok Sharma, Ting Zhang, Yuchen Wu, Xianting Ding
Natural triterpenes represent a group of pharmacologically active and structurally diverse organic compounds. The focus on these phytochemicals has been enormous in the past few years, worldwide. Asiatic acid (AA), a naturally occurring pentacyclic triterpenoid, is found mainly in the traditional medicinal herb Centella asiatica. Triterpenoid saponins, which are the primary constituents of C. asiatica, are commonly believed to be responsible for their extensive therapeutic actions. Published research work has described the molecular mechanisms underlying the various biological activities of AA and its derivatives, which vary for each chronic disease...
January 1, 2018: SLAS Technology
https://www.readbyqxmd.com/read/29354820/asiatic-acid-suppresses-neuroinflammation-in-bv2-microglia-via-modulation-of-the-sirt1-nf-%C3%AE%C2%BAb-signaling-pathway
#7
Yisong Qian, Zhaochen Xin, Yanni Lv, Ziwei Wang, Li Zuo, Xiang Huang, Yunman Li, Hong-Bo Xin
Asiatic acid, a triterpenoid derived from Centella asiatica, has been found to exhibit multiple bioactivities. In this study, we investigated the effects of asiatic acid on lipopolysaccharide (LPS)-induced neuroinflammation and explored the mechanism of its action in BV2 microglia. We found that asiatic acid (0.1 to 100 μM) treatment significantly attenuated nitric oxide (NO) production and inhibited inducible nitric oxide synthase (iNOS) expression in a concentration-dependent manner following LPS exposure...
January 22, 2018: Food & Function
https://www.readbyqxmd.com/read/29287383/change-of-phenolics-carotenoids-and-antioxidant-capacity-following-simulated-gastrointestinal-digestion-and-dialysis-of-selected-edible-green-leaves
#8
K D P P Gunathilake, K K D S Ranaweera, H P V Rupasinghe
The bio-accessibility of phenolics, flavonoids, rutin, β-carotene and lutein and changes in antioxidant activities in six edible greens during simulating gastro-intestinal conditions has been investigated. It was found that the amount of dialysable phenolics, flavonoids and carotenoids which potentially available for further uptake is varying depending on the leafy type. Bioavailable phenolics after the gastric-phase, intestinal-phase and in dialysable fraction were in the ranges of 13.9-71.8%, 14.4-77.4% and 3...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29248451/features-and-outcomes-of-drugs-for-combination-therapy-as-multi-targets-strategy-to-combat-alzheimer-s-disease
#9
REVIEW
Atish Kumar Sahoo, Jagnehswar Dandapat, Umesh Chandra Dash, Satish Kanhar
ETHNOPHARMACOLOGICAL RELEVANCE: Alzheimer's disease (AD), a deleterious neurodegenerative disorder that impairs memory, cognitive functions and may lead to dementia in late stage of life. The pathogenic cause of AD remains incompletely understood and FDA approved drugs are partial inhibitors rather than curative. Most of drugs are synthetic or natural products as galanthamine is an alkaloid obtained from Galanthus spp. Huperzine A, an alkaloid found in Huperzia spp., gingkolides a diterpenoids from Gingko biloba and many ethnobotanicals like Withania somnifera (L...
December 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29210992/characterization-of-the-asiatic-acid-glucosyltransferase-ugt73ah1-involved-in-asiaticoside-biosynthesis-in-centella-asiatica-l-urban
#10
Ok Tae Kim, Mei Lan Jin, Dae Young Lee, Reinhard Jetter
Centella asiatica (L.) Urban contains two ursane-type triterpene saponins, asiaticoside and madecassoside, as major secondary metabolites. In order to select candidate genes encoding UDP-glucosyltransferases (UGTs) involved in asiaticoside biosynthesis, we performed transcriptomic analysis of leaves elicited by methyl jasmonate (MeJA). Among the unigenes, 120 isotigs and 13 singletons of unique sequences were annotated as UGTs, including 37 putative full-length cDNAs, and 15 of the putative UGT genes were named according to the UGT committee nomenclature protocols...
December 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29209345/differentiation-of-three-centella-species-in-australia-as-inferred-from-morphological-characteristics-issr-molecular-fingerprinting-and-phytochemical-composition
#11
Ali Alqahtani, Jun-Lae Cho, Ka Ho Wong, Kong M Li, Valentina Razmovski-Naumovski, George Q Li
Centella asiatica is one of the popular herbs used for inflammatory and neural conditions. Its differentiation from similar species is currently lacking. The aims of this study were to differentiate the three closely related Centella species using methods based on morphological characters, genetic biodiversity, phytochemical compositions and antioxidant activities. According to the morphological characteristics, the collected samples were identified as three species: C. asiatica, Centella cordifolia and Centella erecta and clustered into three groups based on their morphometric variability...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29175795/phytochemical-screening-gc-ms-analysis-and-in-vitro-antioxidant-activity-of-pollen-of-centella-asiatica-linn-urban-a-traditional-medicinal-plant
#12
Andleeb Anwar Sardar, Anjum Perveen, Zaheer-Ud-Din Khan, Sidra Farid, Islamullah Khan
In the present study the crude extracts of pollen of Centella asiatica (Linn.) Urban were explored for their antioxidant potential using Ferric Reducing Power, Metal Chelating Activity and Trolox Equivalent Antioxidant Capacity assays. In crude extracts of pollen antioxidant components were initially extracted in methanol and further fractionated in solvents of different polarity, such as n-Hexane, Chloroform, Ethyl Acetate and Water exhibited reasonable antioxidant activity. The extract was found to contain large amounts of phenolic and flavonoid contents ranged from 143-1155 mg/l of gallic acid equivalent (GAE) and 911-2488 mg/l of quercetin (QE) respectively...
November 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29156835/indonesian-herbal-medicine-prevents-hypertension-induced-left-ventricular-hypertrophy-by-diminishing-nadph-oxidase-dependent-oxidative-stress
#13
Erna Sulistyowati, Jong-Hau Hsu, Yuan-Bin Cheng, Fang-Rong Chang, Ying-Fu Chen, Jwu-Lai Yeh
Indonesian herbal medicine Centella asiatica, Justicia gendarussa and Imperata cylindrica decoction (CJID) are known to be efficacious for hypertension. Oxidative stress plays an important role in hypertension-induced left ventricular hypertrophy (H-LVH). This study evaluated whether CJID inhibit cardiac remodeling in spontaneously hypertensive rats (SHRs) through mechanism of oxidative stress-related cardiac-NADPH oxidase (NOXs) pathway: NOX1, NOX2 and NOX4. Forty-weeks-old SHRs and normotensive-WKY rats, were both randomly divided into 2 groups: CJID and control...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29053421/development-of-a-novel-herbal-formulation-to-inhibit-biofilm-formation-in-toxigenic-vibrio-cholerae
#14
Diana Jose, N Lekshmi, A K Goel, R Ajay Kumar, Sabu Thomas
Vibrio cholerae, a causative agent of the waterborne disease cholera, still threatens a large proportion of world's population. The role of biofilm formation in V. cholerae pathogenesis is well established, as it provides the bacterium enhanced tolerance to antimicrobial agents and increased transmission. In the present study, four medicinal plants used in traditional medicines with antidiarrheal properties were evaluated for its antibiofilm activity. Methanol extracts of these plants (Centella asiatica, Elephantopus scaber, Camellia sinensis, and Holarrhena antidysenterica) showed promising antibiofilm activity against V...
October 20, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/29040016/centella-asiatica-fraction-3-suppresses-the-nuclear-factor-erythroid-2-related-factor-2-anti-oxidant-pathway-and-enhances-reactive-oxygen-species-mediated-cell-death-in-cancerous-lung-a549-cells
#15
Dhaneshree Bestinee Naidoo, Alisa Phulukdaree, Krishnan Anand, Vikash Sewram, Anil Amichund Chuturgoon
Centella asiatica is a tropical medicinal plant that is commonly used in traditional medicine. Medicinal properties of C. asiatica include anti-oxidant, anti-inflammatory, and anti-cancer activity. We investigated the anti-oxidant and anti-proliferative/cytotoxic effects of a semi-purified fraction of C. asiatica ethanolic leaf extract (C3) in cancerous lung A549 cells. C3 was obtained by silica column fractionation and identified by using thin-layer chromatography and gas chromatography mass spectrometry. Cytotoxicity of C3 in A549 cells was evaluated (cell viability assay-WST-1; 24 h; [0...
October 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29032741/titrated-extract-of-centella-asiatica-increases-hair-inductive-property-through-inhibition-of-stat-signaling-pathway-in-three-dimensional-spheroid-cultured-human-dermal-papilla-cells
#16
Yeong Min Choi, Sungkwan An, Junwoo Lee, Jae Ho Lee, Jae Nam Lee, Young Sam Kim, Kyu Joong Ahn, In-Sook An, Seunghee Bae
Dermal papilla (DP) is a pivotal part of hair follicle, and the smaller size of the DP is related with the hair loss. In this study, we investigated the effect of titrated extract of Centella asiatica (TECA) on hair growth inductive property on 3D spheroid cultured human DP cells (HDP cells). Significantly increased effect of TECA on cell viability was only shown in 3D sphered HPD cells, not in 2D cultured HDP cells. Also, TECA treatment increased the sphere size of HDP cells. The luciferase activity of STAT reporter genes and the expression of STAT-targeted genes, SOCS1 and SOCS3, were significantly decreased...
October 16, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28993954/obesity-alleviating-potential-of-asiatic-acid-and-its-effects-on-acc1-ucp2-and-cpt1-mrna-expression-in-high-fat-diet-induced-obese-sprague-dawley-rats
#17
P Rameshreddy, V V Sathibabu Uddandrao, Parim Brahmanaidu, S Vadivukkarasi, Ramavat Ravindarnaik, Pothani Suresh, K Swapna, A Kalaivani, Parimi Parvathi, P Tamilmani, Ganapathy Saravanan
The present study evaluated the effects of asiatic acid (AA), a pentacyclic triterpenoid from Centella asiatica on lipid metabolism parameters in a rat model of obesity induced using a high fat diet (HFD) for 42 days. AA (20 mg/kg body weight [BW]) was administered orally once daily for 42 days, and an orlistat-treated group of rats (10 mg/kg BW) was included for comparison. Changes in BW, blood glucose levels, insulin resistance and leptin, adiponectin, amylase, and lipase levels in the blood; lipid profiles of plasma; liver antioxidants levels; and acetyl CoA carboxylase(ACC), uncoupling protein-2 (UCP2), and carnitine palmitoyltransferase-1 (CPT1) mRNA expression were observed in the experimental rats...
October 9, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28930619/asiatic-acid-nullified-aluminium-toxicity-in-in-vitro-model-of-alzheimer-s-disease
#18
Mashoque Ahmad Rather, Arokiasamy Justin Thenmozhi, Thamilarasan Manivasagam, Jegadeesan Nataraj, Musthafa Mohamed Essa, Saravana Babu Chidambaram
Aluminium (Al) is a ubiquitously distributed environmental toxicant that lacks biological functions; however, its accumulation in the brain has been demonstrated to be linked to several neuropathological conditions particularly Alzheimer's disease (AD). Asiatic acid (AA), a triterpene extracted from Centella asiatica, has been reported to cross the blood brain barrier and also displayed antioxidant and neuroprotective activities. The present study was aimed to explore the neuroprotective effect of AA against aluminium maltolate (Al(mal)3) induced neurotoxicity by assessing cell viability, mitochondrial membrane potential, levels of reactive oxygen species (ROS), DNA damage and apoptosis (Hoechst and dual staining, comet assay; expressions of pro-apoptotic, anti-apoptotic and signaling indices) via AKT/GSK-3β signaling pathway in SH-SY 5Y  neuroblastoma cells...
January 1, 2018: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28930532/neuroprotective-role-of-asiatic-acid-in-aluminium-chloride-induced-rat-model-of-alzheimer-s-disease
#19
Mashoque Ahmad Rather, Arokiasamy Justin Thenmozhi, Thamilarasan Manivasagam, Mathiyazahan Dhivya Bharathi, Musthafa Mohamed Essa, Gilles J Guillemin
Alzheimer's disease (AD) is the most common form of dementia, characterized by memory loss, cognitive impairment and personality disorders accompanied by diffuse structural abnormalities in the brain of elderly people. The current investigation explored the neuroprotective potential of asiatic acid (AA), a natural triterpene of Centella asiatica on aluminium chloride (AlCl3) induced rat model of AD. Oral administration of AlCl3 (100 mg/kg b.w.) for 42 days significantly elevated the levels of Al, activity of acetyl cholinesterase and expressions of amyloid precursor protein, amyloid beta1-42, beta and gamma secretases, glial fibrillary acidic protein, ionized calcium binding adaptor molecule 1, interleukins -1β, 6, 4, 2, tumor necrosis factor alpha, inducible nitric oxide synthase, nuclear factor- k beta and cyclooxygenase-2 in the hippocampus and cortex  compared to the control group...
January 1, 2018: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/28905277/on-site-phytoremediation-applicability-assessment-in-alur-ilmu-universiti-kebangsaan-malaysia-based-on-spatial-and-pollution-removal-analyses
#20
Mohd Hafiyyan Mahmud, Khai Ern Lee, Thian Lai Goh
The present paper aims to assess the phytoremediation performance based on pollution removal efficiency of the highly polluted region of Alur Ilmu urban river for its applicability of on-site treatment. Thirteen stations along Alur Ilmu were selected to produce thematic maps through spatial distribution analysis based on six water quality parameters of Malaysia's Water Quality Index (WQI) for dry and raining seasons. The maps generated were used to identify the highly polluted region for phytoremediation applicability assessment...
October 2017: Environmental Science and Pollution Research International
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