Manon Denis, Thomas Dupas, Antoine Persello, Justine Dontaine, Laurent Bultot, Charlotte Betus, Thomas Pelé, Justine Dhot, Angélique Erraud, Anaïs Maillard, Jérôme Montnach, Aurélia A Leroux, Edith Bigot-Corbel, Didier Vertommen, Matthieu Rivière, Jacques Lebreton, Arnaud Tessier, Michel De Waard, Luc Bertrand, Bertrand Rozec, Benjamin Lauzier
Sepsis in the young population, which is particularly at risk, is rarely studied. O -GlcNAcylation is a post-translational modification involved in cell survival, stress response and metabolic regulation. O -GlcNAc stimulation is beneficial in adult septic rats. This modification is physiologically higher in the young rat, potentially limiting the therapeutic potential of O -GlcNAc stimulation in young septic rats. The aim is to evaluate whether O -GlcNAc stimulation can improve sepsis outcome in young rats...
August 26, 2021: International Journal of Molecular Sciences