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syncitial virus

Gilberto González-Parra, José F Querales, Diego Aranda
lntroduction: The respiratory syncitial virus is one of the most common causes of mortality in children and older adults in the world. Objective: To predict the initial week of outbreaks and to establish the most relevant climate variables using naive Bayes classifiers and receiver operating characteristic curves (ROC). Materials and methods: The initial dates of the outbreaks in children less than five years old for the period 2005-2010 were obtained for Bogotá, Colombia. We selected the climatological variables using a correlation matrix and we constructed 1,020 models using different climatological variables and data from different weeks previous to the initial outbreak...
September 1, 2016: Biomédica: Revista del Instituto Nacional de Salud
Franz J J Rieder, Julia Biebl, Marie-Theres Kastner, Martina Schneider, Christof Jungbauer, Monika Redlberger-Fritz, William J Britt, Michael Kundi, Christoph Steininger
B-cell recognition of microbial antigens may be limited by masking of epitopes within three-dimensional structures (cryptotopes). Here we report that unmasking of cryptotopes by unfolding whole cytomegalovirus (CMV) antigen preparations with the chaotropic reagent Urea and probing with immune sera from healthy individuals (n = 109) increased ELISA signals by 36% in comparison to folded CMV antigens (P < 0.001). ELISA signals increased also significantly upon unfolding of S. aureus or E. coli antigens, whereas unfolded influenza H1N1 or respiratory syncitial virus antigens yielded reduced or unchanged reactivity in comparison to folded ones, respectively...
August 19, 2016: Scientific Reports
Patrice Diot, Laurent Plantier
No abstract text is available yet for this article.
May 2016: Respiratory Care
Mustapha Oumouna, Michael Weitnauer, Vedrana Mijošek, Lotte M Schmidt, Tatjana Eigenbrod, Alexander H Dalpke
Airway epithelial cells (AEC) are the first line of defense against airborne infectious microbes and play an important role in regulating the local immune response. However, the interplay of epithelial cells and professional immune cells during both homeostasis and infection has only been partially studied. The present study was performed to determine how bronchial epithelial cells affect the activation of monocytes. Under healthy conditions, AECs were shown to inhibit reactivity of monocytes. We hypothesized that upon infection, monocytes might be released from inhibition by AECs...
November 2015: Immunobiology
Amir Abd El Qader, David Lieberman, Yonat Shemer Avni, Natali Svobodin, Tsilia Lazarovitch, Orli Sagi, Yehuda Zeiri
Respiratory infections (RI) can be viral or bacterial in origin. In either case, the invasion of the pathogen results in production and release of various volatile organic compounds (VOCs). The present study examines the VOCs released from cultures of five viruses (influenza A, influenza B, adenovirus, respiratory syncitial virus and parainfluenza 1 virus), three bacteria (Moraxella catarrhalis, Haemophilus influenzae and Legionella pneumophila) and Mycoplasma pneumoniae isolated colonies. Our results demonstrate the involvement of inflammation-induced VOCs...
December 2015: Biomedical Chromatography: BMC
Theophilus K Adiku, Richard H Asmah, Onike Rodrigues, Bamenla Goka, Evangeline Obodai, Andrew A Adjei, Eric S Donkor, George Armah
The study aimed to investigate the aetiological agents and clinical presentations associated with acute lower respiratory infections (ALRI) among children under five years old at the Korle-Bu Teaching Hospital in Ghana. This was a cross-sectional study carried from February to December 2001. Nasopharyngeal aspirates and venous blood specimens obtained from 108 children with features suggestive of ALRI, were cultured and the isolated bacterial organisms were identified biochemically. Nasopharyngeal aspirates were also tested for Respiratory Syncitial Virus (RSV) antigen using a commercial kit (Becton Dickinson Directigen RSV test kit)...
2015: Pathogens
Sebastian Scheer, Christine Krempl, Carsten Kallfass, Stefanie Frey, Thilo Jakob, Gabriel Mouahid, Hélène Moné, Annette Schmitt-Gräff, Peter Staeheli, Marinus C Lamers
The human intestinal parasite Schistosoma mansoni causes a chronic disease, schistosomiasis or bilharzia. According to the current literature, the parasite induces vigorous immune responses that are controlled by Th2 helper cells at the expense of Th1 helper cells. The latter cell type is, however, indispensable for anti-viral immune responses. Remarkably, there is no reliable literature among 230 million patients worldwide describing defective anti-viral immune responses in the upper respiratory tract, for instance against influenza A virus or against respiratory syncitial virus (RSV)...
2014: PloS One
Zidnia M Colón Blanco, Christian S Colón Rivera, Migdalis Matos González, Brenda L Pérez Valentín, Renato Rivera Fernández, Isamir Santiago Méndez, Vielka Cintron
Acute respiratory infections are the main reason for pediatric visits both to physician's offices and emergency departments. Bronchiolitis is an acute viral respiratory disease that affects about 10% of infants each year and mostly those under age two. The aim of this study was to identify demographic, epidemiological characteristics and risk factors associated with cases of bronchiolitis admitted to the Manati Medical Center (MMC). In addition, we tried to establish the basis for the development of strategies to prevent of hospitalizations and complications in our Institution...
2014: Boletín de la Asociación Médica de Puerto Rico
G Moreno-Solís, J Torres-Borrego, M J de la Torre-Aguilar, F Fernández-Gutiérrez, F J Llorente-Cantarero, J L Pérez-Navero
BACKGROUND: Respiratory syncytial virus acute bronchiolitis (RSV-AB) is a major cause of hospital admission among our infants. The immune and inflammatory mechanisms involved in the RSV-AB and factors influencing severity have not been clearly established, although an imbalanced Th1 and Th2 response seems to be crucial. OBJECTIVES: To assess the local and systemic inflammatory response in RSV-AB. To find a possible marker of clinical severity and/or oxygen requirements...
May 2015: Allergologia et Immunopathologia
N Domínguez-Pinilla, S Belda Hofheinz, J L Vivanco Martinez, M Baro-Fernández, J Ruiz-Contreras, L I González-Granado
INTRODUCTION: Respiratory syncytial virus (RSV) infection is associated with an increase in morbidity and mortality in immunocompromised hosts. METHODS: A description is presented of all cases of RSV infection in immunocompromised pediatric patients in Hematology and Oncology and Immunodeficiency Units between 2008 and 2012. RESULTS: Nineteen patients were diagnosed with RSV infection. Nine patients required in-patient care and 2 required Pediatric Intensive Care Unit...
January 2015: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
N Van Overstraeten-Schlögel, O Lefèvre, N Couniot, D Flandre
The specificity of biosensors is typically obtained by surface biofunctionalization, which enables the selective binding of biomolecules. This critical step is sensitive to the nature of materials and to the overall experimental conditions. Here, we provide a comprehensive study of several biofunctionalization methods, including the layer-by-layer technique and both the gas-phase and liquid-phase silanizations, and we propose a new maleimide-based protocol for grafting a protein to a sensor covered by alumina...
September 2014: Biofabrication
Massimo Giangaspero, Giovanni Savini, Riccardo Orusa, Takeshi Osawa, Ryô Harasawa
Ovine sera collected in the Prefectures of Hokkaido, Aomori and Iwate in the Northern Japan were examined for the presence of antibodies against Respiratory syncytial virus (RSV), bovine Herpesvirus type 1 (infectious bovine rhinotracheitis: IBR) and Parainfluenza virus type 3 (PIV3) using serum neutralisation (SN) and enzyme-linked immunosorbent assay (ELISA) tests. Twenty-three animals (11.73%) out of the 196 tested were sero-positive to PIV3. Sixteen animals (8.69%) out of the 184 tested reacted to RSV. No animals were positive to IBR antigen...
July 2013: Veterinaria Italiana
Antonio Del Vecchio, Teresa Ferrara, Marco Maglione, Letizia Capasso, Francesco Raimondi
Respiratory syncitial virus (RSV) is the most common cause of lower respiratory tract infections (LRTI) in children worldwide and it is associated with significant childhood morbidity. Acute infection may result in respiratory failure with varying degrees of severity, and increasing evidence supports a role of RSV infection as a key determinant for the development of subsequent chronic respiratory disease. Independent predictors of RSV severity include; prematurity, congenital heart disease, cystic fibrosis, immune defects and neuromuscular disorders...
October 2013: Journal of Maternal-fetal & Neonatal Medicine
Ismail Tavsu, Tugba Gursoy, Sukriye Dirman, Nazan Erbil, Fahri Ovali
AIM: To evaluate the rehospitalization rates of premature infants who received palivizumab prophylaxis and its influence on the growth and development of these infants. METHODS: Infants with a gestational age of less than 32 weeks were randomized to receive prophylaxis with palivizumab (study group) or nothing (control group). Nasal swab samples were obtained monthly in all cases and also in case of infection and hospitalization. At the corrected age of 18 months Guide for Monitoring Child Development (GMCD) was administered to all patients and anthropometric indices were evaluated...
September 2014: American Journal of Perinatology
J Casey, K Morris, M Narayana, M Nakagaki, G A Kennedy
The prognosis for patients with respiratory syncytial virus (RSV) or parainfluenza virus type 3 (PIV3) respiratory tract infection post allogeneic haematopoietic progenitor cell transplant (HPCT) is historically poor. The use of oral ribavirin (RBV) has not been widely studied in this patient population. We examined the outcomes of 15 consecutive patients (RSV, n=13 and PIV3, n=2) treated with oral RBV post HPCT. Oral RBV was commenced at a starting dose of 10 mg/kg/day, increasing to a maximum dose of 60 mg/kg/day depending on response and tolerance...
November 2013: Bone Marrow Transplantation
L Sun, T T Cornell, A LeVine, A A Berlin, V Hinkovska-Galcheva, A J Fleszar, N W Lukacs, T P Shanley
RSV lower respiratory tract infections (LRTI) are among the most common diseases necessitating hospital admission in children. In addition to causing acute respiratory failure, RSV infections are associated with sequelae such as secondary bacterial infections and reactive airway disease. One characteristic host response observed in severe RSV-induced LRTI and/or subsequent development of asthma is increased expression of interleukin (IL)-10. However, contradictory results have been reported regarding whether IL-10 inhibits asthmatic responses or intensifies the disease...
May 2013: Clinical and Experimental Immunology
N Clancy, C Onwuneme, A Carroll, R McCarthy, M J McKenna, N Murphy, E J Molloy
Vitamin D deficiency is widespread in the neonatal and paediatric population of northern latitudes, particularly in children of African, Middle Eastern and Asian ethnicity. This is associated with diminished immune function and increases the risk of Th1 autoimmune diseases like type 1 diabetes. Epidermiological studies have also shown a link between vitamin D deficiency in children and a more severe course of illness with lower respiratory tract infection or Respiratory Syncitial Virus (RSV) bronchiolitis. The mechanism by which vitamin D enhances immunity is complex...
May 2013: Journal of Maternal-fetal & Neonatal Medicine
Stephen C Land
BACKGROUND/AIMS: Chemokine signaling from airway epithelium regulates macrophage recruitment to the lung in inflammatory diseases such as asthma. This study investigates the mechanism by which the α-melanocyte stimulating hormone-derived tripeptide, KPV, and the agonist of the dominant melanocortin receptor in airway epithelium (MC3R), γ-melanocyte stimulating hormone (γ-MSH), suppress inflammation in immortalised human bronchial airway epithelium. METHODS: TNFα and rhino syncitial virus (RSV)-evoked nuclear factor-κB (NFκB) signaling was measured in immortalised human bronchial epithelial cells (16HBE14o-) in response to KPV and γMSH...
2012: International Journal of Physiology, Pathophysiology and Pharmacology
L Iordache, J Gaudelus, D Hubert, O Launay
Vaccination guidelines in patients with cystic fibrosis associate the usual vaccination schedule with specific recommendations concerning influenza, Pneumococcus, viral hepatitis A and B and varicella. Live attenuated vaccines are not contra-indicated but must be administered before pulmonary transplantation. Clinical studies evaluating vaccine efficacy in this population are still necessary. Development of new vaccines against respiratory infections (Staphylococcus aureus, Pseudomonas aeruginosa and Syncitial Respiratory Virus in particular) is an important challenge for the medical management of these patients...
May 2012: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Claire Walker, Susan Danby, Steve Turner
UNLABELLED: Bronchiolitis is a common lower respiratory tract infection of infancy where management has varied considerably in the past. The aim of the present study was to determine whether patient treatment and outcomes changed after introduction of a clinical care pathway. Infants aged up to 6 months admitted to hospital with bronchiolitis were identified as part of an annual audit of bronchiolitis management between winters 2003/2004 and 2009/2010. The primary outcome, duration of stay (DOS), was compared before and after the clinical pathway was introduced before the winter 2005/2006...
May 2012: European Journal of Pediatrics
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