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JOURNAL ARTICLE
Zhenxing Zhang, Shan Wang, Kelong Tao, Guolin Zhang, Danling Guo, Yu Zhang, Guangen Xu
BACKGROUND: Gastric intramural hematoma is a rare disease. Here we report a case of spontaneous isolated gastric intramural hematoma combined with spontaneous superior mesenteric artery intermural hematoma. CASE PRESENTATION: A 75-years-old man was admitted to our department with complaints of abdominal pain. He underwent a whole abdominal computed tomography (CT) scan in the emergency department, which showed extensive thickening of the gastric wall in the gastric body and sinus region with enlarged surrounding lymph nodes, localized thickening of the intestinal wall in the transverse colon, localized indistinct demarcation between the stomach and transverse colon, and a small amount of fluid accumulation in the abdominal cavity...
April 23, 2024: BMC Geriatrics
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JOURNAL ARTICLE
Haichao Wu, Long Zhou, Qiang Wang, Tao Wang, Siyuan Liang
The article aimed to compare the efficiency and safety of aspirin with low-molecular-weight heparin (LMWH) for thromboprophylaxis in orthopaedic surgery patients. According to the inclusion and exclusion criteria, PubMed, Embase and Cochrane Library database were searched for studies comparing aspirin and LMWH in venous thromboembolism (VTE) prophylaxis until 25 April 2023. The outcome measures included deep venous thrombosis(DVT)/Pulmonary embolism(PE) events, major bleeding events, wound complications, wound infection and death...
April 17, 2024: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
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JOURNAL ARTICLE
Bin Wang, Yanhui Su, Cong Ma, Lining Xu, Qunxia Mao, Wenjia Cheng, Qingming Lu, Ying Zhang, Rong Wang, Yan Lu, Jing He, Shihao Chen, Lei Chen, Tianzhi Li, Linggen Gao
BACKGROUND: Little is known about the safety and efficacy of discontinuing antiplatelet therapy via LMWH bridging therapy in elderly patients with coronary stents implanted for > 12 months undergoing non-cardiac surgery. This randomized trial was designed to compare the clinical benefits and risks of antiplatelet drug discontinuation via LMWH bridging therapy. METHODS: Patients were randomized 1:1 to receive subcutaneous injections of either dalteparin sodium or placebo...
April 23, 2024: BMC Medicine
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JOURNAL ARTICLE
Aysenur Onalan, Erdem Gurkas, Cetin Kursad Akpinar, Ozlem Aykac, Zehra Uysal Kocabas, Hasan Dogan, Musa Temel, Atilla Ozcan Ozdemir
INTRODUCTION: The awareness of nonocclusive thrombus has increased with the increasing frequency of imaging methods used for acute ischemic stroke; however, the best treatment for nonocclusive thrombi is still unknown. In this study, we examined how anticoagulants affect supra-aortic artery nonocclusive thrombus and clinical outcomes. MATERIALS AND METHODS: This study included 52 patients with transient ischemic attack or stroke who were diagnosed with nonocclusive thrombi on computed tomography angiography at admission...
April 20, 2024: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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REVIEW
Lina Khider, Benjamin Planquette, David M Smadja, Olivier Sanchez, Carla Rial, Guillaume Goudot, Emmanuel Messas, Tristan Mirault, Nicolas Gendron
BACKGROUND: Post-thrombotic syndrome (PTS) is the main long-term complication of deep vein thrombosis (DVT). Several therapies are being evaluated to prevent or to treat PTS. Identifying the patients most likely to benefit from these therapies presents a significant challenge. OBJECTIVES: The objective of this review was to identify risk factors for PTS during the acute phase of DVT. ELIGIBILITY CRITERIA: We searched the PubMed and Cochrane databases for studies published between January 2000 and January 2021, including randomized clinical trials, meta-analyses, systematic reviews and observational studies...
April 12, 2024: Thrombosis Research
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JOURNAL ARTICLE
Joana Liz-Pimenta, Valéria Tavares, João Gramaça, João Rato, Maria Menezes, Mafalda Baleiras, Helena Guedes, Joana Reis, Catarina Guedes, Rosa Gomes, Miguel Barbosa, Marta Sousa, Alok A Khorana, Rui Medeiros
INTRODUCTION: Cancer-associated thrombosis (CAT) is a significant concern among patients with malignant diseases, leading to increased mortality. While current guidelines recommend primary thromboprophylaxis for venous thromboembolism (VTE) in medium-to-high-risk outpatients, this practice remains controversial. A better understanding of primary thromboprophylaxis is crucial, yet there is a lack of Real-World Evidence (RWE) in Portugal. AIMS: This RWE study aimed to elucidate primary thromboprophylaxis practices among cancer outpatients in Portugal...
April 20, 2024: Journal of Thrombosis and Thrombolysis
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JOURNAL ARTICLE
Diana Andronic, Octavian Andronic, Elias Ammann, Edward Pravin, Rachael Cubberley
INTRODUCTION: There are currently different management guidelines for patients undergoing elective total hip arthroplasty (THA) or total knee arthroplasty (TKA) that are on long-term anticoagulation. The timing of discontinuation and restarting the anticoagulation is challenging during the postoperative care, which often involves general practitioners and physiotherapists. METHODS: The systematic review followed the PRISMA guidelines and included 3 databases: PubMed/MEDLINE, EMBASE, and Web of Science Core Collection...
April 19, 2024: Family Practice
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JOURNAL ARTICLE
Michele Massimo Gulizia, Fabio Maria Turazza, Pietro Ameri, Marco Alings, Ronan Collins, Leonardo De Luca, Marcello Di Nisio, Donata Lucci, Domenico Gabrielli, Stefan Janssens, Iris Parrini, Fausto J Pinto, Jose Luis Zamorano, Furio Colivicchi
BACKGROUND: Cancer is an important condition associated with the development of atrial fibrillation (AF). The objectives of the BLITZ-AF Cancer study were to collect real-life information on the clinical profile and use of antithrombotic drugs in patients with AF and cancer to improve clinical management, as well as the evaluation of the association between different antithrombotic treatments (or their absence) and the main clinical events. METHODS: European multinational, multicenter, prospective, non-interventional study conducted in patients with AF (electrocardiographically confirmed) and cancer occurring within 3 years...
May 2024: Giornale Italiano di Cardiologia
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Nivedha Balaji, Oluwafemi Olukayode, Fardeen Faiz, Priyadarshini Dixit, Vedang Bhavsar
Mechanical heart valves (MHVs) are thrombogenic and require lifelong anticoagulation with vitamin K antagonists (VKAs) such as warfarin. Periprocedural bridging with unfractionated heparin (UFH) and low-molecular-weight heparin (LMWH) aims to reduce the risk of thromboembolic events in patients. Currently, there are no definitive class I recommendations for anticoagulation management in patients with MHVs. In this report, we present the case of a 77-year-old female who was perioperatively bridged with enoxaparin and subsequently developed an acute thrombus...
March 2024: Curēus
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JOURNAL ARTICLE
C Weimar, J Beyer-Westendorf, F O Bohmann, G Hahn, S Halimeh, S Holzhauer, C Kalka, M Knoflach, H-C Koennecke, F Masuhr, M-L Mono, U Nowak-Göttl, E Scherret, M Schlamann, B Linnemann
Over the last years, new evidence has accumulated on multiple aspects of diagnosis and management of cerebral venous and dural sinus thrombosis (CVT) including identification of new risk factors, studies on interventional treatment as well as treatment with direct oral anticoagulants. Based on the GRADE questions of the European Stroke Organization guideline on this topic, the new German guideline on CVT is a consensus between expert representatives of Austria, Germany and Switzerland. New recommendations include:• CVT occurring in the first weeks after SARS-CoV-2 vaccination with vector vaccines may be associated with severe thrombocytopenia, indicating the presence of a prothrombotic immunogenic cause (Vaccine-induced immune thrombotic thrombocytopenia; VITT)...
April 19, 2024: Neurological research and practice
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JOURNAL ARTICLE
Laura Peña-Blanco, Laura Gutiérrez-Soriano, Félix Ramón Montes, Andrea Barragán-Méndez, Susana Beltrán-Villegas, Juan José López-Reyes, Carlos A Villa-Hincapié, Juan Pablo Umaña
BACKGROUND: Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome is a severe adverse drug reaction marked by delayed hypersensitivity reactions causing skin and systemic complications. DRESS diagnosis is challenging due to the variety of clinical presentations and symptom overlap with other conditions. The perioperative period in these patients requires precise pharmacological strategies to prevent complications associated with this syndrome. The treatment of DRESS induced by unfractionated heparin during cardiopulmonary bypass (CPB) surgery presents some challenges that must be considered when selecting an anticoagulant to avoid side effects...
April 17, 2024: Journal of Cardiothoracic Surgery
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JOURNAL ARTICLE
Stephanie Lager, Gautam Balakrishnan, Riley Eiberger
BACKGROUND: Low molecular weight heparin has proven to be safe and effective but is not without potential risks such as spontaneous bleeding in the abdominal cavity. There is limited evidence evaluating the true incidence of this potential risk and the available literature is primarily via case reports. CASE SUMMARY: The purpose of this study was to identify the incidence and risk factors associated with enoxaparin use (prophylaxis or treatment) abdominal hematomas in a 350-bed community hospital during an 8-month time period...
2024: PloS One
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JOURNAL ARTICLE
Yang Liu, Jian-Ping Cheng, Xiao-Lin Zhao
AIM: To investigate the impact of triglyceride on hypertriglyceridemic acute pancreatitis (HTG-AP) and different lipid-lowering methods on triglyceride-lowering efficiency and HTG-AP. METHODS: The patients with HTG-AP from January 2012 to December 2023 in Civil Aviation General Hospital were analyzed, retrospectively. Patients were divided and compared according to whether their triglycerides were below 5.56 mmol/L at 48 and 72 h of admission. The patients were divided into control group, insulin group, and low molecular weight heparin (LMWH)+bezafibrate group based on the different methods of lipid-lowering...
April 16, 2024: Scandinavian Journal of Gastroenterology
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M Martínez Díaz, A Costa Roig, M E Carazo Palacios, I Viguria Marco, A Marco Macián, D Crehuet Gramatyka
INTRODUCTION: Hematomas are a rare cause of intestinal obstruction. Subcutaneous heparin can bring about direct punctures on small bowel loops, potentially leading to traumatic hematoma and intestinal obstruction. CASE REPORTS: We present three cases of pediatric patients with clinical signs of intestinal obstruction treated with subcutaneous heparin. Two cases had increased acute-phase reactants and radiological signs of intestinal suffering, so surgical treatment was decided upon, with intramural hematoma emerging as an intraoperative finding...
April 1, 2024: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
#15
Yassir Balla, Abdullahi Said Hashi, Ahmed Adam Osman, Mohamed Sheikh Hassan, Eren Mutlu
Cerebral sinovenous thrombosis (CSVT) encompasses a spectrum of disorders involving thrombosis of the cerebral venous system. As shown by previous epidemiological studies, the prevalence of cerebral sinovenous thrombosis is 4-7 cases per million people. Nephrotic syndrome was very rarely associated with thrombosis cerebral veins or sinuses. Hypercoagulability and thrombotic complications in nephrotic syndrome are most commonly seen in deep veins of the lower extremities and renal veins. Our case highlights a unique scenario in which cerebral sinovenous thrombosis was the initial presentation of nephrotic syndrome in a patient that was not an important past medical or surgical problem...
2024: Vascular Health and Risk Management
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JOURNAL ARTICLE
Lejan Schultinge, Anne-Marije Hulshof, Danihel van Neerven, Mark M G Mulder, Jan-Willem E M Sels, Hendrina P M G Hulsewe, Gerardus J A J M Kuiper, Renske H Olie, Hugo Ten Cate, Iwan C C van der Horst, Bas C T van Bussel, Yvonne M C Henskens
BACKGROUND: Critically ill COVID-19 patients are at risk for venous thromboembolism (VTE). Therefore, they receive thromboprophylaxis and, when appropriate, therapeutic unfractionated heparin (UFH) or low-molecular-weight heparin (LMWH). To monitor heparins in COVID-19 disease, whole-blood rotational thromboelastometry (ROTEM) may be a promising alternative to the aPTT and anti-Xa assays. OBJECTIVE: To evaluate the ROTEM INTEM/HEPTEM ratios in mechanically ventilated COVID-19 patients treated with UFH and therapeutic LMWH...
August 2023: Thromb Update
#17
Julie Benzakine, Carla Rial, Nassim Mohamedi, Emmanuel Messas, Laetitia Mauge, Marc Sapoval, Nicolas Gendron, Lina Khider
BACKGROUND: Inherited antithrombin (AT) deficiency (ATD) is a severe thrombophilia causing venous thromboembolism, which can be complicated by postthrombotic syndrome (PTS). Venous recanalization, used to treat PTS, often requires a temporary withdrawal of anticoagulant therapy. In ATD patients, there is a risk of insufficient perioperative anticoagulation due to altered heparin response. KEY CLINICAL QUESTION: There is no consensus on how to manage perioperative anticoagulation in ATD patients...
March 2024: Research and Practice in Thrombosis and Haemostasis
#18
JOURNAL ARTICLE
Asanthi M Ratnasekera, Sirivan S Seng, Daniel Kim, Wenyan Ji, Christina L Jacovides, Elinore J Kaufman, Hannah M Sadek, Lindsey L Perea, Christina Monaco Poloni, Ilya Shnaydman, Alexandra Jeongyoon Lee, Victoria Sharp, Angela Miciura, Eric Trevizo, Martin G Rosenthal, Lawrence Lottenberg, William Zhao, Alicia Keininger, Michele Hunt, John Cull, Chassidy Balentine, Tanya Egodage, Aleem T Mohamed, Michelle Kincaid, Stephanie Doris, Robert Cotterman, Sara Seegert, Lewis E Jacobson, Jamie Williams, Melissa Moncrief, Brandi Palmer, Caleb Mentzer, Nichole Tackett, Tjasa Hranjec, Thomas Dougherty, Shawna Morrissey, Lauren Donatelli-Seyler, Amy Rushing, Leah C Tatebe, Tiffany J Nevill, Michel B Aboutanos, David Hamilton, Diane Redmond, Daniel C Cullinane, Carolyne Falank, Mark McMellen, Chris Duran, Jennifer Daniels, Shana Ballow, Kevin M Schuster, Paula Ferrada
BACKGROUND: In patients with severe traumatic brain injury (TBI), clinicians must balance preventing venous thromboembolism (VTE) with the risk of intracranial hemorrhagic expansion (ICHE). We hypothesized that low molecular weight heparin (LMWH) would not increase risk of ICHE or VTE as compared to unfractionated heparin (UH) in patients with severe TBI. METHODS: Patients ≥ 18 years of age with isolated severe TBI (AIS ≥ 3), admitted to 24 level I and II trauma centers between January 1, 2014 to December 31, 2020 and who received subcutaneous UH and LMWH injections for chemical venous thromboembolism prophylaxis (VTEP) were included...
April 9, 2024: Injury
#19
JOURNAL ARTICLE
James French, Keslin Greenwood
No abstract text is available yet for this article.
November 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
#20
JOURNAL ARTICLE
Mariya Cherenko, Natasha M Appelman-Dijkstra, Ana Luisa Priego-Zurita, N R Biermasz, Olaf Dekkers, F A Klok, Nicole Reisch, Anna Aulinas, Betina Biagetti, Salvatore Cannavo, Letizia Canu, Mario Detomas, France Devuyst, Henrik Falhammar, Richard A Feelders, Francesco Ferrau, F Gatto, Chiara Grasselli, Pepijn van Houten, Charlotte Hoybye, Andrea M Isidori, Aglaia Kyrilli, Paola Loli, Dominique Maiter, Elisabeth Dorothea Susanne Nowak, Rosario Pivonello, Oskar Ragnarsson, Rebecca V Steenaard, Nicole Unger, Annenienke C Van de Ven, Susan M Webb, Diego Yeste, S Faisal Ahmed, Alberto M Pereira
BACKGROUND: Patients with Cushing syndrome (CS) are at increased risk of venous thromboembolism (VTE). OBJECTIVE: To evaluate current management of new cases of CS with a focus on VTE and thromboprophylaxis. DESIGN AND METHODS: A survey was conducted within those that report in electronic reporting tool (e-REC) of The European Registries for Rare Endocrine Conditions (EuRRECa) and the involved main thematic groups (MTG's) of the European Reference Networks for Rare Endocrine Disorders (Endo-ERN) on new patients with CS from January 2021 until July 2022...
April 1, 2024: Endocrine Connections
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