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JOURNAL ARTICLE
Áine M de Bhailis, Edward Lake, Constantina Chrysochou, Darren Green, Rajkumar Chinnadurai, Philip A Kalra
BACKGROUND AND OBJECTIVES: Atherosclerotic renal artery stenosis may cause hypertension, chronic kidney disease and heart failure, but large randomized control trials to date have shown no major additional benefit of renal revascularization over optimal medical management. However, these trials did not consider outcomes specifically in relation to clinical presentations. Given that atherosclerotic renal artery stenosis is a heterogenous condition, measures of success likely differ according to the clinical presentation...
April 9, 2024: Journal of Nephrology
#2
JOURNAL ARTICLE
Miloud Cherbi, Eric Bonnefoy, Etienne Puymirat, Nicolas Lamblin, Edouard Gerbaud, Laurent Bonello, Bruno Levy, Pascal Lim, Laura Muller, Hamid Merdji, Grégoire Range, Emile Ferrari, Meyer Elbaz, Hadi Khachab, Jeremy Bourenne, Marie-France Seronde, Nans Florens, Guillaume Schurtz, Vincent Labbé, Brahim Harbaoui, Gerald Vanzetto, Nicolas Combaret, Benjamin Marchandot, Benoit Lattuca, Guillaume Leurent, Stanislas Faguer, François Roubille, Clément Delmas
BACKGROUND: Chronic kidney disease (CKD) is one of the leading causes of death worldwide, closely interrelated with cardiovascular diseases, ultimately leading to the failure of both organs - the so-called "cardiorenal syndrome". Despite this burden, data related to cardiogenic shock outcomes in CKD patients are scarce. METHODS: FRENSHOCK (NCT02703038) was a prospective registry involving 772 patients with cardiogenic shock from 49 centres. One-year outcomes (rehospitalization, death, heart transplantation, ventricular assist device) were analysed according to history of CKD at admission and were adjusted on independent predictive factors...
March 20, 2024: Archives of Cardiovascular Diseases
#3
JOURNAL ARTICLE
Daniel Edmonston, Michaela A A Fuchs, Emily J Burke, Tamara Isakova, Myles Wolf
RATIONALE & OBJECTIVE: Klotho deficiency may affect clinical outcomes in chronic kidney disease (CKD) through fibroblast growth factor-23 (FGF23)-dependent and independent pathways. However, the association between circulating Klotho and clinical outcomes in CKD remains unresolved and was the focus of this study. STUDY DESIGN: Prospective observational study. SETTING & PARTICIPANTS: 1088 participants of the Chronic Renal Insufficiency Cohort (CRIC) Study with estimated glomerular filtration rate (eGFR) 20-70 ml/min/1...
April 5, 2024: American Journal of Kidney Diseases
#4
REVIEW
Mehmet Kanbay, Sidar Copur, Berk Mizrak, Francesca Mallamaci, Carmine Zoccali
BACKGROUND: The fundamental role of the renin-angiotensin-aldosterone system in the pathophysiology of chronic kidney disease, congestive heart failure, hypertension and proteinuria is well established in pre-clinical and clinical studies. Mineralocorticoid receptor antagonists are among the primary options for renin-angiotensin-aldosterone system blockage, along with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. METHODS: In this narrative review, we aim to evaluate the efficiency and safety of mineralocorticoid receptor antagonists in kidney transplant recipients, including the potential underlying pathophysiology...
April 5, 2024: European Journal of Clinical Investigation
#5
JOURNAL ARTICLE
Elena M Donald, Daniel Oren, Ersilia M DeFilippis, Gal Rubinstein, Catherine M Moeller, Hannah Y Lee, Alejandro Maldonado, Mary Virginia Portera, Byron Fuselier, Ruslana Jackson, Kevin J Clerkin, Justin A Fried, Jayant Raikhelkar, Sun Hi Lee, Farhana Latif, Irene D Lytrivi, Warren A Zuckerman, Marc E Richmond, Gabriel Sayer, Nir Uriel
BACKGROUND: There are limited data evaluating the success of a structured transition plan specifically for pediatric heart transplant (HT) recipients following their transfer of care to an adult specialist. We sought to identify risk factors for poor adherence, graft failure, and mortality following the transfer of care to adult HT care teams. METHODS: We retrospectively reviewed all patients who underwent transition from the pediatric to adult HT program at our center between January 2011 and June 2021...
April 2024: Clinical Transplantation
#6
JOURNAL ARTICLE
Keren Skalsky, Leor Perl, Benaya Rozen Zvi, Mohamad Atamna, Ran Kornowski, Eviatar Nesher, Ruth Rahamimov, Tuvia Ben Gal, Yaron Shapira, Arthur Shyovich, Tali Steinmetz
INTRODUCTION: End-stage renal disease (ESRD) is a major risk factor for cardiovascular morbidity and mortality, which can be partially eliminated by kidney transplantation. Systolic heart failure might be considered as contraindication for kidney transplant although some patients demonstrate myocardial recovery post-transplant. We aim to identify and characterize the phenomenon of reverse myocardial remodelling in kidney transplanted patients. METHODS: The study is a retrospective cohort of patients undergoing kidney transplant between 2016-2019 (n=604) at Rabin Medical Center...
March 26, 2024: Cardiology
#7
JOURNAL ARTICLE
Sandro Sponga, Igor Vendramin, Veronica Ferrara, Michela Marinoni, Giulia Valdi, Concetta Di Nora, Chiara Nalli, Giovanni Benedetti, Daniela Piani, Andrea Lechiancole, Maria Parpinel, Uberto Bortolotti, Ugolino Livi
Metabolic Syndrome (MetS), a multifactorial condition that increases the risk of cardio-vascular events, is frequent in Heart-transplant (HTx) candidates and worsens with immunosuppressive therapy. The aim of the study was to analyze the impact of MetS on long-term outcome of HTx patients. Since 2007, 349 HTx patients were enrolled. MetS was diagnosed if patients met revised NCEP-ATP III criteria before HTx, at 1, 5 and 10 years of follow-up. MetS was present in 35% of patients pre-HTx and 47% at 1 year follow-up...
2024: Transplant International
#8
JOURNAL ARTICLE
Ahmad Mustafa, Samer Asmar, Chapman Wei, John Afif, Shahkar Khan, Taqi Rizvi, Radu Grovu, Mitchell Weinberg, Suzanne El-Sayegh
BACKGROUND: Cardiovascular disease (CVD) is the leading cause of mortality in kidney transplant (KT) patients. The perceived risk of contrast-induced nephropathy (CIN) may create a reluctance to perform coronary angiography in patients presenting with non-ST segment elevation myocardial infarction (NSTEMI). METHODS: National Inpatient Sample (NIS) Database was used to sample individuals presenting with NSTEMI. Patients were stratified into KT and Non-KT cohorts...
June 2023: American heart journal plus: cardiology research and practice
#9
JOURNAL ARTICLE
Daniel Oren, Matan Uriel, Cathrine M Moeller, Andrea Fernandez Valledor, Ersilia M DeFilippis, Dor Lotan, Paolo C Colombo, Melana Yuzefpolskaya, Veli K Topkara, Kevin J Clerkin, Jayant K Raikhelkar, Justin A Fried, David Kyung Taek Oh, David Bae, Eddie Lin, Kleanthis Theodoropoulos, Yoshifumi Naka, Koji Takeda, Jason Choe, Douglas L Jennings, David Majure, Farhana Latif, Gabriel Sayer, Nir Uriel
BACKGROUND: Belatacept (BTC), a fusion protein, selectively inhibits T-cell co-stimulation by binding to the CD80 and CD86 receptors on antigen-presenting cells (APCs) and has been used as immunosuppression in adult renal transplant recipients. However, data regarding its use in heart transplant (HT) recipients are limited. This retrospective cohort study aimed to delineate BTC's application in HT, focusing on efficacy, safety, and associated complications at a high-volume HT center. METHODS: A retrospective cohort study was conducted of patients who underwent HT between January 2017 and December 2021 and subsequently received BTC as part of their immunosuppressive regimen...
March 2024: Clinical Transplantation
#10
REVIEW
Nakeya Dewaswala, Huzefa Bhopalwala, Abdul Mannan Khan Minhas, Khadija Amanullah, Dmitry Abramov, Samiullah Arshad, Sourbha Dani, Gaurang Vaidya, Dipanjan Banerjee, Emma Birks, Erin Michos
INTRODUCTION: Advanced heart failure therapies and heart transplantation (HT) have been underutilized in women. Therefore, we aimed to explore the clinical characteristics and outcomes of HT by sex. METHODS: We conducted a retrospective analysis of adult discharges from the National Inpatient Sample (NIS) between 2012 and 2019. International Classification of Disease (ICD) procedure codes were used to identify those who underwent HT. RESULTS: A total of 20,180 HT hospitalizations were identified from 2012-2019...
March 16, 2024: Current Problems in Cardiology
#11
JOURNAL ARTICLE
Hannah Kreienbaum, Brigitte Stiller, Rouven Kubicki, Alexej Bobrowski, Johannes Kroll, Thilo Fleck
BACKGROUND: Immunosuppression after heart transplantation (HTX) with mammalian target of rapamycin (mTOR) inhibitors serves as a prophylaxis against rejection and to treat coronary vascular injury. However, there is little data on the early, preventive use of everolimus after pediatric HTX. METHODS: Retrospective study of 61 pediatric HTX patients (48 cardiomyopathy and 13 congenital heart disease), 28 females, median age 10.1 (range 0.1-17.9) years transplanted between 2008 and 2020...
March 2024: Pediatric Transplantation
#12
JOURNAL ARTICLE
Massimo Nardone, Vikas S Sridhar, Kevin Yau, Ayodele Odutayo, David Z I Cherney
Volume overload represents a hallmark clinical feature linked to the development and progression of heart failure (HF). Alleviating signs and symptoms of volume overload represents a foundational HF treatment target that is achieved using loop diuretics in the acute and chronic setting. Recent work has provided evidence to support guideline-directed medical therapies, such as sodium glucose cotransporter 2 (SGLT2) inhibitors and mineralocorticoid receptor (MR) antagonists, as important adjunct diuretics that may act synergistically when used with background loop diuretics in people with chronic HF...
February 29, 2024: Nephrology, Dialysis, Transplantation
#13
JOURNAL ARTICLE
Biff F Palmer, Deborah J Clegg
Hyperkalemia is a common electrolyte disturbance in both inpatient and outpatient clinical practice. The severity and associated risk depends on the underlying cause and rate of K+ increase. Acute hyperkalemia requires immediate attention due to potentially life-threatening manifestations resulting from the rapid rise in plasma K+ concentration. Treatment is initially focused on stabilizing the cardiac membrane, followed by maneuvers to shift K+ into the cell, and ultimately initiating strategies to decrease total body K+ content...
February 29, 2024: Nephrology, Dialysis, Transplantation
#14
REVIEW
Chih-Yao Hsu, Ching-Yuan Yeh, Tsung-Yi Yen, Ching-Chu Chen, Jung-Fu Chen, Chih-Hsun Chu, Chien-Ning Huang, Ching-Ling Lin, Shih-Yi Lin, Feng-Hsuan Liu, Horng-Yih Ou, Chih-Yuan Wang
Increasing prevalence of type 2 DM (T2DM) and diabetic kidney disease (DKD) has posed a great impact in Taiwan. However, guidelines focusing on multidisciplinary patient care and patient education remain scarce. By literature review and expert discussion, we propose a consensus on care and education for patients with DKD, including general principles, specifics for different stages of chronic kidney disease (CKD), and special populations. (i.e. young ages, patients with atherosclerotic cardiovascular disease or heart failure, patients after acute kidney injury, and kidney transplant recipients)...
February 28, 2024: Primary Care Diabetes
#15
JOURNAL ARTICLE
Bram Akerboom, Roemer J Janse, Aurora Caldinelli, Bengt Lindholm, Joris I Rotmans, Marie Evans, Merel van Diepen
BACKGROUND AND HYPOTHESIS: Non-traumatic lower extremity amputation (LEA) is a severe complication during dialysis. To inform decision-making for physicians, we developed a multivariable prediction model for LEA after starting dialysis. METHODS: Data from the Swedish Renal Registry (SNR) between 2010 and 2020 were geographically split into a development and validation cohort. Data from NECOSAD between 1997 and 2009 were used for validation targeted at Dutch patients...
February 26, 2024: Nephrology, Dialysis, Transplantation
#16
JOURNAL ARTICLE
Torki Al Otaibi, Ayman Nagib, Prasad Nair, Medhat A Halim, Mahmoud Khaled, Mohamed A Hammad, Tarek S Mahmoud, Islam Sobhy, Zakaria Zakaria, Ahmed Atta, Ahmed Deraz, Ahmed Mostafa, Mohamed Abuelmagd, Mohamed Shaker, Nabil Alserwy, Zoheer Fyyad, Suzann Rida, Hasaneen Aboatya, Mohamed Adel, Mohamed Balaha, Khaled Atea, Osama Gheith
OBJECTIVES: Renal complications of COVID-19 are not yet well studied. We aimed to evaluate acute kidney injury prevalence among hospitalized patients with COVID-19 infection and explore its effect on patient outcomes. MATERIALS AND METHODS: We retrospectively evaluated 586 hospitalized patients with COVID-19. Of these patients, 267 (45.5%) developed acute kidney injury, as classified according to the Kidney Disease Improving Global Outcomes guidelines. We compared this group with 319 patients (54...
January 2024: Experimental and Clinical Transplantation
#17
JOURNAL ARTICLE
Matylda Mazur, Geetha Bhat, Eric Popjes, Robert Dowling, Howard J Eisen
BACKGROUND: Heart transplantation (HT) is the only option for most patients with end-stage heart failure and hypertrophic cardiomyopathy (HCM) who fail medical therapy. Data on the long-term outcomes post-transplant in HCM individuals remain scarce. METHODS: We analyzed data of 319 adult patients who underwent HT between 1984 and 2019. Patients were followed for cardiac allograft rejection, cardiac allograft vasculopathy (CAV), death, or re-transplantation. RESULTS: Outcomes of 24 patients with HCM, 160 with ischemic, and 135 with dilated cardiomyopathy were compared...
February 2024: Clinical Transplantation
#18
JOURNAL ARTICLE
Runguo Wu, Claire Williams, Junwen Zhou, Iryna Schlackow, Jonathan Emberson, Christina Reith, Anthony Keech, John Robson, Jane Armitage, Alastair Gray, John Simes, Colin Baigent, Borislava Mihaylova, Jane Armitage, Colin Baigent, Elizabeth Barnes, Lisa Blackwell, Rory Collins, Kelly Davies, Jonathan Emberson, Jordan Fulcher, Heather Halls, William G Herrington, Lisa Holland, Anthony Keech, Adrienne Kirby, Borislava Mihaylova, Rachel O'Connell, David Preiss, Christina Reith, John Simes, Kate Wilson, Michael Blazing, Eugene Braunwald, James de Lemos, Sabina Murphy, Terje R Pedersen, Marc Pfeffer, Harvey White, Stephen Wiviott, Michael Clearfield, John R Downs, Antonio Gotto, Stephen Weis, Bengt Fellström, Hallvard Holdaas, Alan Jardine, Terje R Pedersen, David Gordon, Barry Davis, Curt Furberg, Richard Grimm, Sara Pressel, Jeffrey L Probstfield, Mahboob Rahman, Lara Simpson, Michael Koren, Björn Dahlöf, Ajay Gupta, Neil Poulter, Peter Sever, Hans Wedel, Robert H Knopp, Stuart Cobbe, Bengt Fellström, Hallvard Holdaas, Alan Jardine, Roland Schmieder, Faiez Zannad, D John Betteridge, Helen M Colhoun, Paul N Durrington, John Fuller, Graham A Hitman, Andrew Neil, Eugene Braunwald, Barry Davis, C Morton Hawkins, Lemuel Moyé, Marc Pfeffer, Frank Sacks, John Kjekshus, Hans Wedel, John Wikstrand, Christoph Wanner, Vera Krane, Maria Grazia Franzosi, Roberto Latini, Donata Lucci, Aldo Maggioni, Roberto Marchioli, Enrico B Nicolis, Luigi Tavazzi, Gianni Tognoni, Jackie Bosch, Eva Lonn, Salim Yusuf, Jane Armitage, Louise Bowman, Rory Collins, Anthony Keech, Martin Landray, Sarah Parish, Richard Peto, Peter Sleight, John Jp Kastelein, Terje R Pedersen, Robert Glynn, Antonio Gotto, John Jp Kastelein, Wolfgang Koenig, Jean MacFadyen, Paul M Ridker, Anthony Keech, Stephen MacMahon, Ian Marschner, Andrew Tonkin, John Shaw, John Simes, Harvey White, Patrick W Serruys, Genell Knatterud, Gerard J Blauw, Stuart Cobbe, Ian Ford, Peter Macfarlane, Chris Packard, Naveed Sattar, James Shepherd, Stella Trompet, Eugene Braunwald, Christopher P Cannon, Sabina Murphy, Rory Collins, Jane Armitage, Louise Bowman, Richard Bulbulia, Richard Haynes, Sarah Parish, Richard Peto, Peter Sleight, Pierre Amarenco, K Michael Welch, John Kjekshus, Terje R Pedersen, Lars Wilhelmsen, Philip Barter, Antonio Gotto, John LaRosa, John Jp Kastelein, James Shepherd, Stuart Cobbe, Ian Ford, Sharon Kean, Peter Macfarlane, Chris Packard, Michele Roberston, Naveed Sattar, James Shepherd, Robin Young, Hiroyuki Arashi, Robert Clarke, Marcus Flather, Shinya Goto, Uri Goldbourt, Jemma Hopewell, G Kees Hovingh, George Kitas, Connie Newman, Marc S Sabatine, Gregory G Schwartz, Liam Smeeth, Jonathan Tobert, John Varigos, Junichi Yamamguchi
BACKGROUND: UK cardiovascular disease (CVD) incidence and mortality have declined in recent decades but socioeconomic inequalities persist. AIM: To present a new CVD model, and project health outcomes and the impact of guideline-recommended statin treatment across quintiles of socioeconomic deprivation in the UK. DESIGN AND SETTING: A lifetime microsimulation model was developed using 117 896 participants in 16 statin trials, 501 854 UK Biobank (UKB) participants, and quality-of-life data from national health surveys...
February 19, 2024: British Journal of General Practice
#19
JOURNAL ARTICLE
G Rajagopalan, Komarakshi R Balakrishnan, K G Suresh Rao, R Ravi Kumar, Ramarathnam Krishna Kumar
BACKGROUND & AIM: The deleterious consequences of chronically elevated venous pressure in patients with profound right ventricular or biventricular dysfunction are well known, including renal and hepatic dysfunction, and volume overload. The only option for these patients, if they fail optimal medical treatment, is a heart transplant, as they are not candidates for left ventricular assist device therapy. Mean perfusion pressure (MPP) is important in the outcomes of critically ill patients with high venous pressure...
February 14, 2024: Heart, Lung & Circulation
#20
JOURNAL ARTICLE
Yunda Wang, Joy Mohnot, Kanhua Yin, Niloo M Edwards, Nikola Dobrilovic, Yong Zhan
BACKGROUND: Type A aortic dissection in heart transplantation recipients is rare and lethal, with limited research beyond case reports. This study aimed to analyze patient characteristics and clinical outcomes of this condition through a US national database. METHODS: The National Inpatient Sample database (2002-2018) was used to identify all type A aortic dissection in heart transplantation recipients aged >18 years. Incidence was quantified annually. Primary outcomes were in-hospital mortality; secondary outcomes were hospital length of stay and complications...
February 14, 2024: Transplantation Proceedings
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