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https://www.readbyqxmd.com/read/29909389/delayed-presentation-of-iatrogenic-splenic-injury-21-days-after-laparoscopic-donor-left-nephrectomy
#1
Kelvin Yafan Wang, Omar Abbassi, Ali Warsi
We report the case of a 46-year-old woman who had presented with left-sided abdominal pain 21 days after undergoing a left-sided laparoscopic nephrectomy for donation. Initial haemoglobin and haematocrit levels were within normal range, and vital signs on admission were unremarkable. Significant intra-abdominal pathology was not suspected; however, inpatient CT scan of the abdomen showed a posterolateral subcapsular splenic haematoma with free abdominal fluid. Initial trial of conservative management was not successful as the patient became hypotensive on the third day of admission with a sudden decrease in haemoglobin and haematocrit...
June 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29908646/an-unusual-case-of-suicide-by-methanol-ingestion
#2
Brian Waters, Kenji Hara, Natsuki Ikematsu, Mio Takayama, Aya Matsusue, Masayuki Kashiwagi, Shin-Ichi Kubo
A female in her late teens purposely ingested alcohol fuel containing methanol to commit suicide, which she admitted on social media. She was found in distress by her parents and died at the hospital some hours later. Autopsy revealed swelling of the brain and edematous and congestive lungs. No other trauma or unusual findings were revealed at autopsy. Methanol was detected upon routine screening for alcohols by headspace gas chromatography with flame-ionization detection. To confirm the presence of methanol and its metabolite formic acid, a method with detection by mass spectrometry was used...
June 4, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29908202/post-translational-protein-deimination-in-cod-gadus-morhua-l-ontogeny-novel-roles-in-tissue-remodelling-and-mucosal-immune-defences
#3
Bergljót Magnadóttir, Polly Hayes, Mariya Hristova, Birkir Þór Bragason, Anthony P Nicholas, Alister W Dodds, Sigríður Guðmundsdóttir, Sigrun Lange
Peptidylarginine deiminases (PADs) are calcium dependent enzymes with physiological and pathophysiological roles conserved throughout phylogeny. PADs promote post-translational deimination of protein arginine to citrulline, altering the structure and function of target proteins. Deiminated proteins were detected in the early developmental stages of cod from 11 days post fertilisation to 70 days post hatching. Deiminated proteins were present in mucosal surfaces and in liver, pancreas, spleen, gut, muscle, brain and eye during early cod larval development...
June 13, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29908030/cutaneous-involvement-in-an-8-year-old-boy-with-ras-associated-autoimmune-leucoproliferative-disorder-rald
#4
A Giacaman, A Bauzá Alonso, J A Salinas Sanz, J L Dapena Díaz, R Ramos Asensio, L Ferrés Ramis, M A Durán Pastor, A Martín-Santiago
Ras-associated autoimmune leucoproliferative disorder (RALD) is a nonmalignant syndrome associated with somatic KRAS mutations. We report a patient with RALD and cutaneous lesions, the first such case reported, to our knowledge. An 8-year-old boy presented with erythematous plaques on his face and body, along with lymphadenopathies and spleen enlargement without systemic symptoms. An increased number of monocytes were found in skin biopsy, peripheral blood and bone marrow (BM). Juvenile myelomonocytic leukaemia (JMML) was suspected...
June 16, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29907210/nonoperative-management-of-penetrating-abdominal-solid-organ-injuries-in-children
#5
Reid Sakamoto, Kazuhide Matsushima, Amory de Roulet, Kristine Beetham, Aaron Strumwasser, Damon Clark, Kenji Inaba, Demetrios Demetriades
BACKGROUND: Nonoperative management (NOM) of penetrating solid organ injuries (SOI) has not been well described in the pediatric population. The objective of this study was to characterize the epidemiology, injury patterns, and factors associated with trial and failure of NOM. METHODS: This is a retrospective cohort analysis of the National Trauma Data Bank for the period of 2007-2014. The study population included patients ≤18 y with penetrating injury to the liver, spleen, or kidney...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29907186/isolation-of-naturally-infecting-leishmania-infantum-from-canine-samples-in-novy-macneal-nicolle-medium-prepared-with-defibrinated-blood-from-different-animal-species
#6
Roseclea Chagas Dos Santos, Flaviane Alves de Pinho, Gabriela Porfírio Passos, Daniela Farias Larangeira, Stella Maria Barrouin-Melo
The most commonly used culture medium for the in vitro isolation of Leishmania spp. from canine biological samples is biphasic Novy-MacNeal-Nicolle (NNN) medium, whose solid phase is prepared using rabbit blood. Leishmania infantum parasites from natural infections are highly sensitive and demanding for growth in axenic conditions when firstly obtained from the dog's body. The objective of this study was to evaluate whether NNN medium (NNN-test) prepared with chicken blood (NNN-C), ox blood (NNN-O), horse blood (NNN-H) or sheep blood (NNN-S) was viable for the isolation of parasites from naturally infected dogs, in an endemic area for visceral leishmaniasis caused by L...
June 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29906541/distribution-of-salmonella-enteritidis-in-internal-organs-and-variation-of-cecum-microbiota-in-chicken-after-oral-challenge
#7
Jinxin Zeng, Changwei Lei, Yulong Wang, Yanpeng Chen, Xiuzhong Zhang, Zhuangzhuang Kang, Xiwen Zhai, Xiaolan Ye, Hongning Wang
The aim of this study was to explore the distribution of Salmonella Enteritidis (S. enteritidis) in internal organs and variation of cecum microbiota in newly hatched chicken after oral challenge during a 21-day period. The quantities of S. enteritidis DNA in different internal organs (heart, liver, spleen, stomach, pancreas, small intestine, blood and cecum contents) were determined by real-time fluorescent quantitative polymerase chain reaction (FQ-PCR). The result showed that all of the above-mentioned samples were positive at 12 h post inoculation (PI) after oral challenge...
June 12, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29906242/angiotensin-ii-receptor-i-blockade-prevents-stenosis-of-tissue-engineered-vascular-grafts
#8
Juan de Dios Ruiz-Rosado, Yong-Ung Lee, Nathan Mahler, Tai Yi, Frank Robledo-Avila, Diana Martinez-Saucedo, Avione Y Lee, Toshihiro Shoji, Eric Heuer, Andrew R Yates, Jordan S Pober, Toshiharu Shinoka, Santiago Partida-Sanchez, Christopher K Breuer
We previously developed a tissue-engineered vascular graft (TEVG) made by seeding autologous cells onto a biodegradable tubular scaffold, in an attempt to create a living vascular graft with growth potential for use in children undergoing congenital heart surgery. Results of our clinical trial showed that the TEVG possesses growth capacity but that its widespread clinical use is not yet advisable due to the high incidence of TEVG stenosis. In animal models, TEVG stenosis is caused by increased monocytic cell recruitment and its classic ("M1") activation...
June 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29905812/defective-cholesterol-metabolism-in-haematopoietic-stem-cells-promotes-monocyte-driven-atherosclerosis-in-rheumatoid-arthritis
#9
Dragana Dragoljevic, Michael J Kraakman, Prabhakara R Nagareddy, Devi Ngo, Waled Shihata, Helene L Kammoun, Alexandra Whillas, Man Kit Sam Lee, Annas Al-Sharea, Gerard Pernes, Michelle C Flynn, Graeme I Lancaster, Mark A Febbraio, Jaye Chin-Dusting, Beatriz Y Hanaoka, Ian P Wicks, Andrew J Murphy
Aim: Rheumatoid arthritis (RA) is associated with an approximately two-fold elevated risk of cardiovascular (CV)-related mortality. Patients with RA present with systemic inflammation including raised circulating myeloid cells, but fail to display traditional CV risk-factors, particularly dyslipidaemia. We aimed to explore if increased circulating myeloid cells is associated with impaired atherosclerotic lesion regression or altered progression in RA. Methods and results: Using flow cytometry, we noted prominent monocytosis, neutrophilia, and thrombocytosis in two mouse models of RA...
June 14, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29905629/local-vancomycin-effectively-reduces-surgical-site-infection-at-implant-site-in-rodents
#10
Jeffrey S Kroin, Jinyuan Li, Sasha Shafikhani, Kajal H Gupta, Mario Moric, Asokumar Buvanendran
BACKGROUND AND OBJECTIVES: Infected implantable devices represent a clinical challenge, because the customary option is to surgically remove the device, and that is associated with substantial cost and morbidity to the patient, along with patient dissatisfaction with the physician. Although prophylactic systemic antibiotics and sterile technique are the mainstay of prevention of surgical site infection (SSI) after implant, the incidence of SSI remains relatively high. Although some surgeons add local antibiotic at implant site during surgery, there is no scientific research to demonstrate if there is a benefit...
June 13, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29905559/-clinical-and-immunological-criteria-for-the-adverse-course-of-infectious-mononucleosis-in-children
#11
Ya Kolesnik, T Zharkova, O Rzhevskaya, T Kvaratskheliya, O Sorokina
The article presents the results of our own studies to determine the criteria for the adverse variants of the course of infectious mononucleosis (IM) in children. The study was conducted in the regional children's infectious clinical hospital in Kharkov. 161 children aged three to fifteen years were under observation with diagnosis of infectious moninucleosis. Out of 161 ill children, 140 (86.9%) had moderate severity of disease, and 21 (13.1%) had severe forms. All children were prescribed standard clinical and laboratory-instrumental examinations...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29904389/rhoa-drives-t-cell-activation-and-encephalitogenic-potential-in-an-animal-model-of-multiple-sclerosis
#12
Alba Manresa-Arraut, Flemming Fryd Johansen, Cord Brakebusch, Shohreh Issazadeh-Navikas, Henrik Hasseldam
T-cells are known to be intimately involved in the pathogenesis of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). T-cell activation is controlled by a range of intracellular signaling pathways regulating cellular responses such as proliferation, cytokine production, integrin expression, and migration. These processes are crucial for the T-cells' ability to mediate inflammatory processes in autoimmune diseases such as MS. RhoA is a ubiquitously expressed small GTPase well described as a regulator of the actin cytoskeleton...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29903311/-physiologically-based-toxicokinetic-model-for-nickel
#13
Hongjun Zhao, Pengfei Ge, Xuhong Chang, Xiaolan Ren, Lijuan Chen, Jinxia Gao, Jianming Hu, Xinghui Li
OBJECTIVE: To estimate the metabolic parameters in different tissues and organs, build the physiologically based pharmacokinetic( PBPK) model of rat and occupational population, and predict the toxic dynamic characteristics exposure to nickel. METHODS: The partition coefficients in different tissues and organs were estimated using vector datas of nickel by the optimization and statistics files of acslx software. The PBTK model of occupational population exposure to nickel was built according to the metabolic parameters by acslx software...
September 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29903059/size-controlled-biocompatible-silver-nanoplates-for-contrast-enhanced-intravital-photoacoustic-mapping-of-tumor-vasculature
#14
Xiaoyong Wang, Lan Zhang, Junqing Wang, Xuan Liu, Peng Lv, Jie Zeng, Gang Liu
Triangular Ag nanoplates with a thickness of 5 nm and tunable edge lengths were fabricated using a seed-mediated protocol, featuring enhanced near-infrared absorption as the edge length of nanoplates increased. The photoacoustic (PA) efficiency of these Ag nanoplates were assessed. Nanoplates with an edge length of 100 nm (r1) performed best among others in the in vitro assessment. In the following in vivo test, r1 nanoplates were also found to boost the PA signal of tumor vessels, while a detailed PA imaging of tumor vasculature was obtained...
August 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29903022/effects-of-plant-essential-oil-supplementation-on-growth-performance-immune-function-and-antioxidant-activities-in-weaned-pigs
#15
Guoqi Su, Xuanwu Zhou, Yu Wang, Daiwen Chen, Guang Chen, Yan Li, Jun He
BACKGROUND: The aim of this study was to determine the effects of plant essential oil supplementation on growth performance, immune function and antioxidant activities in weaned pigs. METHODS: In the study, 24 weaned pigs were used to explore the effects of plant essential oil (PEO) on growth performance, immune properties and antioxidant activities. Pigs were fed with a basal diet (CON) or basal diet containing different concentrations of PEO (PEO50: 50 ppm; PEO100: 100 ppm; PEO200: 200 ppm)...
June 15, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29902886/-the-network-pharmacological-mechanisms-of-four-anti-vitiligo-uyghur-medicines-based-on-phlegmatic-temperament-theory
#16
Ji-Ye Wang, Xiao-Qin Wang, Yun Tang, Bo Zhang
To explore the network pharmacological mechanisms of four anti-vitiligo Uyghur medicines based on the Phlegmatic temperament theory. First, The anti-vitiligo Uyghur medicine formulas based on Phlegmatic temperament theory were collected. The pharmacokinetic characteristic of main compounds in four anti-vitiligo Uyghur medicines were obtained by using admetSAR. The targets of active compounds were predicted via bSDTNBI (balanced substructure-drug-target network-based inference model) method. Then, biological process (BP) and molecular function (MF) enrichment analysis of targets were analysed via DAVID database...
May 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29902336/mast-cell-and-plasma-cell-collision-tumor-in-the-spleen-of-a-dog
#17
Valarie A Pallatto, Molly A Bechtold
A 9-year-old spayed female English Mastiff was referred for outpatient ultrasound due to a 3-week history of weight loss, vomiting, and decreased appetite. Abdominal ultrasound showed multiple splenic masses of varying sizes and serum chemistry panel showed hyperglobulinemia. Cytologic examination of fine-needle aspirates of the splenic masses indicated a mast cell and plasma cell collision tumor. Results of serum and urine protein electrophoresis and immunofixation indicated the plasma cell neoplasia was producing IgA immunoglobulins...
June 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29901197/cxcl9-promotes-prostate-cancer-progression-through-inhibition-of-cytokines-from-t-cells
#18
Shanfeng Tan, Kai Wang, Fuguang Sun, Yang Li, Yisheng Gao
Chemokines have been demonstrated to serve an important role in a variety of diseases, particularly in tumor progression. There have been numerous studies that have reported that T cells serve major roles in tumor progression. However, the function of CXC motif chemokine ligand 9 (CXCL9) in prostate cancer remains unknown. The present study aimed to investigate the role of CXCL9 in prostate cancer. A prostate cancer mouse model was generated by treating C57/BL‑6 and B6.Cg‑Selplgtm1Fur/J mice with 3,2'‑dimethyl 4‑aminobiphenyl (DMAB)...
June 11, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29901140/spleen-tyrosine-kinase-promotes-nlr-family-pyrin-domain-containing-3-inflammasome%C3%A2-mediated-il%C3%A2-1%C3%AE-secretion-via-c%C3%A2-jun-n%C3%A2-terminal-kinase-activation-and-cell-apoptosis-during-diabetic-nephropathy
#19
Yingchun Qiao, Xixi Tian, Li Men, Shengyu Li, Yufeng Chen, Meiting Xue, Yahui Hu, Pengfei Zhou, Guangfeng Long, Yue Shi, Ruiqing Liu, Yunde Liu, Zhi Qi, Yujie Cui, Yanna Shen
Diabetic nephropathy (DN) is a serious complication of diabetes and can cause an increased mortality risk. It was previously reported that NLR family pyrin domain containing 3 (NLRP3) inflammasome is involved in the pathogenesis of diabetes. However, the underlying mechanism is not clearly understood. In the present study, the effects of spleen tyrosine kinase (Syk) and c‑Jun N‑terminal kinase (JNK) on the NLRP3 inflammasome were examined in vivo and in vitro. Sprague‑Dawley rats were injected intraperitoneally with streptozotocin (65 mg/kg) to induce diabetes...
June 14, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29901094/fennel-main-constituent-trans%C3%A2-anethole-treatment-against-lps%C3%A2-induced-acute-lung-injury-by-regulation-of-th17-treg-function
#20
Sichao Zhang, Xi Chen, Ichinkhorloo Devshilt, Qi Yun, Cong Huang, Lijun An, Sosorburam Dorjbat, Xin He
Fennel, commonly used in traditional Chinese medicine, is known as Foeniculum vulgare Mill. And its clinical application has been shown to target many biological systems including gastroenterology, endocrinology, gynecology and respiratory. The main constituent of the fennel essential oil is trans‑anethole, which has been described to have anti‑inflammatory and antibacterial activities. The aim of the present study was to define the anti‑inflammatory influence in acute lung injury (ALI)‑bearing mice...
June 7, 2018: Molecular Medicine Reports
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