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https://www.readbyqxmd.com/read/28822387/indicators-of-survival-and-favorable-functional-outcomes-after-decompressive-craniectomy-a-multi-institutional-retrospective-study
#1
Abid D Khan, Anna J Elseth, Brian Head, Jack Rostas, Julie A Dunn, Thomas J Schroeppel, Richard P Gonzalez
The role of decompressive craniectomy (DC) for severe traumatic brain injury (STBI) remains controversial. The purpose of this study was to identify factors that are indicators of survival and improved functional outcome in patients who undergo DC for STBI. A retrospective review of STBI patients who underwent DC was performed at four trauma centers during a 45-month period. Data collected included age, gender, mechanism of injury, Injury Severity Score (ISS), admission Glasgow Coma Scale (GCS), time from admission to DC, mortality, and extended Glasgow Outcome Score before discharge...
August 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28821516/a-retrospective-review-of-paediatric-head-injuries-in-asia-a-pan-asian-trauma-outcomes-study-patos-collaboration
#2
Shu-Ling Chong, Uzma Rahim Khan, Indumathy Santhanam, Jun Seok Seo, Quan Wang, Sabariah Faizah Jamaluddin, Quoc Ai Hoang Trong, Su Yah Chew, Marcus Eng Hock Ong
OBJECTIVE: We aim to examine the mechanisms of head-injured children presenting to participating centres in the Pan Asian Trauma Outcomes Study (PATOS) and to evaluate the association between mechanism of injury and severe outcomes. DESIGN AND SETTING: We performed a retrospective review of medical records among emergency departments (EDs) of eight PATOS centres, from September 2014 - August 2015. PARTICIPANTS: We included children <16 years old who presented within 24 hours of head injury and were admitted for observation or required a computed tomography (CT) of the brain from the ED...
August 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28818092/associations-of-thyroid-hormone-serum-levels-with-in-vivo-alzheimer-s-disease-pathologies
#3
Hyo Jung Choi, Min Soo Byun, Dahyun Yi, Bo Kyung Sohn, Jun Ho Lee, Jun-Young Lee, Yu Kyung Kim, Dong Young Lee
BACKGROUND: The present study investigated the relationships between thyroid hormone serum levels or thyroid-stimulating hormone (TSH) and two Alzheimer's disease (AD)-specific biomarkers, cerebral amyloid beta (Aβ) burden and glucose metabolism, in AD-signature brain regions in cognitively normal (CN) middle-aged and older individuals. METHODS: This study assessed 148 CN individuals who received comprehensive clinical and neuropsychological assessments that included (11)C-Pittsburgh Compound B (PiB)-positron emission tomography (PET) scans, (18)F-deoxyglucose (FDG)-PET scans, and the quantification of serum triiodothyronine (T3), free T3, free thyroxine (fT4), and TSH levels...
August 17, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28814387/effects-of-nk1-receptors-on-gastric-motor-functions-and-satiation-in-healthy-humans-results-from-a-controlled-trial-with-the-nk1-antagonist-aprepitant
#4
Deepti Jacob, Irene A Busciglio, Duane D Burton, Houssam Halawi, Ibironke Oduyebo, Deborah Rhoten, Michael Ryks, W Scott Harmsen, Michael Camilleri
Aprepitant, an NK1 receptor antagonist, is approved for the treatment of chemotherapy-induced or postoperative emesis by blocking NK1 receptors in the brain stem vomiting center. Effects of NK1 receptors on gastric functions and postprandial symptoms in humans are unclear; a single, crossover study did not show a significant effect of aprepitant on gastrointestinal transit. Our aim was to compare, in a randomized, double-blind, placebo-controlled, parallel-group study (12 healthy volunteers per group), effects of aprepitant vs...
August 16, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28810939/roadway-aggression-among-drivers-and-passengers-with-or-without-a-history-of-traumatic-brain-injury
#5
Gabriela Ilie, Christine Wickens, Robert Mann, Anca Ialomiteanu, Edward Adlaf, Hayley Hamilton, Mark Asbridge, Jürgen Rehm, Michael Cusimano
OBJECTIVE: This study examined the association between roadway aggression and traumatic brain injury (TBI) among drivers and passengers who reside in the province of Ontario, Canada. METHODS: Data were based on a 3-year cumulated cross-sectional sample of 6,048 adults aged 18 years and older who were surveyed by telephone. The outcome in this study was road rage in the form of verbal/gestural or physical aggression toward other road users and/or their vehicle. RESULTS: Driving status, history of TBI, age, gender, education, and the interaction between history of TBI and education significantly predicted roadway aggression...
August 15, 2017: Violence and Victims
https://www.readbyqxmd.com/read/28809667/nonlinear-dynamic-complexity-and-sources-of-resting-state-eeg-in-abstinent-heroin-addicts
#6
Qinglin Zhao, Hua Jiang, Bin Hu, Yonghui Li, Ning Zhong, Mi Li, Wenhua Lin, Quanying Liu
It has been reported that chronic heroin intake induces both structural and functional changes in human brain; however, few studies have investigated the carry-over adverse effects on brain after heroin withdrawal. In this paper, we examined the neurophysiological differences between the abstinent heroin addicts (AHAs) and healthy controls (HCs) using nonlinear dynamic analysis and source localization analysis in resting-state electroencephalogram (EEG) data; 5 min resting EEG data from 20 AHAs and twenty age-, education-, and gender-matched HCs were recorded using 64 electrodes...
July 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28807870/an-open-multi-vendor-multi-field-strength-brain-mr-dataset-and-analysis-of-publicly-available-skull-stripping-methods-agreement
#7
REVIEW
Roberto Souza, Oeslle Lucena, Julia Garrafa, David Gobbi, Marina Saluzzi, Simone Appenzeller, Letícia Rittner, Richard Frayne, Roberto Lotufo
This paper presents an open, multi-vendor, multi-field strength magnetic resonance (MR) T1-weighted volumetric brain imaging dataset, named Calgary-Campinas-359 (CC-359). The dataset is composed of images of older healthy adults (29-80 years) acquired on scanners from three vendors (Siemens, Philips and General Electric) at both 1.5 T and 3 T. CC-359 is comprised of 359 datasets, approximately 60 subjects per vendor and magnetic field strength. The dataset is approximately age and gender balanced, subject to the constraints of the available images...
August 11, 2017: NeuroImage
https://www.readbyqxmd.com/read/28806742/dissociating-maternal-responses-to-sad-and-happy-facial-expressions-of-their-own-child-an-fmri-study
#8
Dorothea Kluczniok, Catherine Hindi Attar, Jenny Stein, Sina Poppinga, Thomas Fydrich, Charlotte Jaite, Viola Kappel, Romuald Brunner, Sabine C Herpertz, Katja Boedeker, Felix Bermpohl
BACKGROUND: Maternal sensitive behavior depends on recognizing one's own child's affective states. The present study investigated distinct and overlapping neural responses of mothers to sad and happy facial expressions of their own child (in comparison to facial expressions of an unfamiliar child). METHODS: We used functional MRI to measure dissociable and overlapping activation patterns in 27 healthy mothers in response to happy, neutral and sad facial expressions of their own school-aged child and a gender- and age-matched unfamiliar child...
2017: PloS One
https://www.readbyqxmd.com/read/28805798/repeated-aav-mediated-gene-transfer-by-serotype-switching-enables-long-lasting-therapeutic-levels-of-hugt1a1-enzyme-in-a-mouse-model-of-crigler-najjar-syndrome-type-i
#9
L Bočkor, G Bortolussi, A Iaconcig, G Chiaruttini, C Tiribelli, M Giacca, F Benvenuti, L Zentilin, A F Muro
Adeno-associated virus (AAV)-mediated gene therapy is a promising strategy to treat liver-based monogenic diseases. However, two major obstacles limit its success: first, vector dilution in actively dividing cells, such as hepatocytes in neonates/children, due to the non-integrating nature of the vector; second, development of an immune response against the transgene and/or viral vector. Crigler-Najjar Syndrome Type I (CNSI) is a rare monogenic disease with neonatal onset, caused by mutations in the liver-specific UGT1 gene, with toxic accumulation of unconjugated bilirubin in plasma, tissues and brain...
August 14, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28805697/multiple-sclerosis-and-schizophrenia
#10
REVIEW
Borros M Arneth
The psychiatric and neurological aspects of health may present methodological challenges in the diagnosis and treatment of disease. This is especially true for patients whose symptoms indicate the coexistence of multiple sclerosis (MS) and schizophrenia (SCZ). These cases raise critical questions regarding the relationship between the mind and the brain. Studies have noted that patients with MS have an increased risk of developing SCZ or bipolar disorder (BD). It is suggested here that MS and a subgroup of SCZ have similar etiologies...
August 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28805078/occurrence-and-predictive-factors-of-heterotopic-ossification-in-severe-acquired-brain-injured-patients-during-rehabilitation-stay-cross-sectional-survey
#11
Stefano Bargellesi, Luisa Cavasin, Federico Scarponi, Antonio De Tanti, Donatella Bonaiuti, Michelangelo Bartolo, Paolo Boldrini, Anna Estraneo
OBJECTIVES: To report occurrence and identify patient's features and risk factors of heterotopic ossifications in patients with severe acquired brain injury in intensive rehabilitation centres. DESIGN: Multicentre cross-sectional survey. SETTING: A total of 48 severe acquired brain injury rehabilitation institutes. PARTICIPANTS: Traumatic and non-traumatic severe brain-injured patients ( N = 689) in rehabilitation centres on 28 May 2016...
August 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28802764/factors-influencing-renal-graft-survival-7-year-experience-of-a-single-center
#12
Rūta Auglienė, Eglė Dalinkevičienė, Vytautas Kuzminskis, Mindaugas Jievaltas, Laima Peleckaitė, Agnė Gryguc, Edgaras Stankevičius, Inga Arūnė Bumblytė
BACKGROUND AND OBJECTIVE: The demand for kidney transplants exceeds the existing supply. This leads to a recently growing interest of research in the area of factors that could prolong graft long-term outcomes and survival. In Lithuania, approximately 90% of kidney transplantations are from deceased donors. Donor organs are received and shared only inside the country territory in Lithuania; therefore, donor data is accurate and precise. This study was performed to present particularities of kidney transplantation data in Lithuania and to identify the effect of donor and recipient factors and histologic findings on renal graft outcomes...
July 29, 2017: Medicina
https://www.readbyqxmd.com/read/28801372/multi-variant-genetic-panel-for-genetic-risk-of-opioid-addiction
#13
Keri Donaldson, Laurence Demers, Kirk Taylor, Joe Lopez, Sherman Chang
Over 116 million people worldwide have chronic pain and prescription dependence. In the US, opioids account for the majority of overdose deaths, and in 2014, almost 2 million Americans abused or were dependent on prescription opioids. Genetic factors may play a key role in opioid prescription addiction. Herein, we describe genetic variations between opioid addicted and non-addicted populations and derive a predictive model determining risk of opioid addiction. This case cohort study compares the frequency of 16 single nucleotide polymorphisms involved in the brain reward pathways in patients with and without opioid addiction...
August 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28798703/neural-correlates-of-morphology-acquisition-through-a-statistical-learning-paradigm
#14
Michelle Sandoval, Dianne Patterson, Huanping Dai, Christopher J Vance, Elena Plante
The neural basis of statistical learning as it occurs over time was explored with stimuli drawn from a natural language (Russian nouns). The input reflected the "rules" for marking categories of gendered nouns, without making participants explicitly aware of the nature of what they were to learn. Participants were scanned while listening to a series of gender-marked nouns during four sequential scans, and were tested for their learning immediately after each scan. Although participants were not told the nature of the learning task, they exhibited learning after their initial exposure to the stimuli...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28795168/changes-in-brain-behavior-relationships-following-a-3-month-pilot-cognitive-intervention-program-for-adults-with-traumatic-brain-injury
#15
S Porter, I J Torres, W Panenka, Z Rajwani, D Fawcett, A Hyder, N Virji-Babul
Facilitating functional recovery following brain injury is a key goal of neurorehabilitation. Direct, objective measures of changes in the brain are critical to understanding how and when meaningful changes occur, however, assessing neuroplasticity using brain based results remains a significant challenge. Little is known about the underlying changes in functional brain networks that correlate with cognitive outcomes in traumatic brain injury (TBI). The purpose of this pilot study was to assess the feasibility of an intensive three month cognitive intervention program in individuals with chronic TBI and to evaluate the effects of this intervention on brain-behavioral relationships...
August 2017: Heliyon
https://www.readbyqxmd.com/read/28795095/quantitative-exploration-of-factors-influencing-psychotic-disorder-ailments-in-nigeria
#16
Adebowale O Adejumo, Nehemiah A Ikoba, Esivue A Suleiman, Hilary I Okagbue, Pelumi E Oguntunde, Oluwole A Odetunmibi, Obalowu Job
In this data article, records on demographic data, family problem issues, as well as results of medical tests from five major classes of psychotic disorder namely: bipolar; vascular dementia, minimal brain dysfunction; insomnia; and schizophrenia, were collected on 500 psychotic patients carefully selected from the pool of medical records of Yaba Psychiatric Hospital, Lagos, Nigeria, for the period of 5 years, between January 2010 and December 2014, were examined. X-squared Statistic was used to examine each of psychotic disorders to identify demographic (age, gender, religion, marital status, and occupation) and family issues (loss of parent, history of such ailment in the family (family status), divorce, head injury, and heredity of such ailment (genetic) factors that influence them...
October 2017: Data in Brief
https://www.readbyqxmd.com/read/28792656/amygdala-and-regional-volumes-in-treatment-resistant-versus-nontreatment-resistant-depression-patients
#17
Anca-Larisa Sandu, Eric Artiges, André Galinowski, Thierry Gallarda, Frank Bellivier, Hervé Lemaitre, Bernard Granger, Damien Ringuenet, Eleni T Tzavara, Jean-Luc Martinot, Marie-Laure Paillère Martinot
BACKGROUND: Although treatment-resistant and nontreatment-resistant depressed patients show structural brain anomalies relative to healthy controls, the difference in regional volumetry between these two groups remains undocumented. METHODS: A whole-brain voxel-based morphometry (VBM) analysis of regional volumes was performed in 125 participants' magnetic resonance images obtained on a 1.5 Tesla scanner; 41 had treatment-resistant depression (TRD), 40 nontreatment-resistant depression (non-TRD), and 44 were healthy controls...
August 9, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28790399/gender-difference-in-spontaneous-deception-a-hyperscanning-study-using-functional-near-infrared-spectroscopy
#18
Mingming Zhang, Tao Liu, Matthew Pelowski, Dongchuan Yu
Previous studies have demonstrated that the neural basis of deception involves a network of regions including the medial frontal cortex (MFC), superior temporal sulcus (STS), temporo-parietal junction (TPJ), etc. However, to test the actual activity of the brain in the act of deceptive practice itself, existing studies have mainly adopted paradigms of passive deception, where participants are told to lie in certain conditions, and have focused on intra-brain mechanisms in single participants. In order to examine the neural substrates underlying more natural, spontaneous deception in real social interactions, the present study employed a functional near-infrared spectroscopy (fNIRS) hyperscanning technique to simultaneously measure pairs of participants' fronto-temporal activations in a two-person gambling card-game...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28790394/interocularly-merged-face-percepts-eliminate-binocular-rivalry
#19
P Christiaan Klink, Daphne Boucherie, Damiaan Denys, Pieter R Roelfsema, Matthew W Self
Faces are important visual objects for humans and other social animals. A complex network of specialized brain areas is involved in the recognition and interpretation of faces. This network needs to strike a balance between being sensitive enough to distinguish between different faces with similar features, and being tolerant of low-level visual changes so that a given face is stably perceived as a particular individual. Such stability may require feedback from higher brain regions down to the level where details are represented...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28789990/descriptive-analysis-of-extracorporeal-cardiopulmonary-resuscitation-following-out-of-hospital-cardiac-arrest-an-elso-registry-study%C3%A2
#20
Nathan L Haas, Ryan A Coute, Cindy H Hsu, James A Cranford, Robert W Neumar
AIM: Extracorporeal cardiopulmonary resuscitation (ECPR) is an emerging therapy for refractory cardiac arrest. The purpose of this study was to analyze and report characteristics and outcomes of adult patients treated with ECPR after out-of-hospital cardiac arrest (OHCA) in a large international registry. METHODS: The Extracorporeal Life Support Organization's Extracorporeal Life Support Registry was queried for adult cardiac arrests with arrest location of "EMT Transport" or "Outside Hospital...
August 5, 2017: Resuscitation
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