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https://www.readbyqxmd.com/read/28727713/local-brain-activity-differences-between-herpes-zoster-and-postherpetic-neuralgia-patients-a-resting-state-functional-mri-study
#1
Song Cao, Ying Li, Wenwen Deng, Bangyong Qin, Yi Zhang, Peng Xie, Jie Yuan, Buwei Yu, Tian Yu
BACKGROUND: Herpes zoster (HZ) can develop into postherpetic neuralgia (PHN), both of which are painful diseases. PHN patients suffer chronic pain and emotional disorders. Previous studies showed that the PHN brain displayed abnormal activity and structural change, but the difference in brain activity between HZ and PHN is still not known. OBJECTIVES: To identify regional brain activity changes in HZ and PHN brains with resting-state functional magnetic resonance imaging (rs-fMRI) technique, and to observe the differences between HZ and PHN patients...
July 2017: Pain Physician
https://www.readbyqxmd.com/read/28723938/gender-differences-in-cerebral-metabolism-for-color-processing-in-mice-a-pet-mri-study
#2
Philip C Njemanze, Mathias Kranz, Mario Amend, Jens Hauser, Hans Wehrl, Peter Brust
INTRODUCTION: Color processing is a central component of mammalian vision. Gender-related differences of color processing revealed by non-invasive functional transcranial Doppler ultrasound suggested right hemisphere pattern for blue/yellow chromatic opponency by men, and a left hemisphere pattern by women. MATERIALS AND METHODS: The present study measured the accumulation of [18F]fluorodeoxyglucose ([18F]FDG) in mouse brain using small animal positron emission tomography and magnetic resonance imaging (PET/MRI) with statistical parametric mapping (SPM) during light stimulation with blue and yellow filters compared to darkness condition...
2017: PloS One
https://www.readbyqxmd.com/read/28715351/interacting-influences-of-gender-and-chronic-pain-status-on-parasympathetically-mediated-heart-rate-variability-in-adolescents-and-young-adults
#3
Lynn S Walker, Amanda L Stone, Craig A Smith, Stephen Bruehl, Judy Garber, Martina Puzanovova, André Diedrich
Considerable research links chronic pain to autonomic nervous system (ANS) dysfunction, specifically low heart rate variability (HRV) mediated by reduced parasympathetic activity. However, little is known about factors that influence ANS function in chronic pain. The ANS is the primary pathway for brain-gut communication, making it of particular interest in gastrointestinal disorders, such as irritable bowel syndrome, characterized by functional abdominal pain (FAP). We evaluated the relation of sex, pain severity, and psychological stress to ANS function in adolescents/young adults from a database of pediatric FAP and control participants enrolled 8 years earlier in a prospective study of pain...
August 2017: Pain
https://www.readbyqxmd.com/read/28711817/selection-and-application-of-familiar-and-novel-tools-in-patients-with-left-and-right-hemispheric-stroke-psychometrics-and-normative-data
#4
Ilka Buchmann, Jennifer Randerath
Frequently left brain damage (LBD) leads to limb apraxia, a disorder that can affect tool-use. Despite its impact on daily life, classical tests examining the pantomime of tool-use and imitation of gestures are seldom applied in clinical practice. The study's aim was to present a diagnostic approach which appears more strongly related to actions in daily life in order to sensitize applicants and patients about the relevance of the disorder before patients are discharged. Two tests were introduced that evaluate actual tool selection and tool-object-application: the Novel Tools (NTT) and the Familiar Tools (FTT) Test (parts of the DILA-S: Diagnostic Instrument for Limb Apraxia - Short Version)...
June 23, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28711621/length-of-axons-expressing-the-serotonin-transporter-in-orbitofrontal-cortex-is-lower-with-age-in-depression
#5
Grazyna Rajkowska, Gouri Mahajan, Beata Legutko, Lavanya Challagundla, Michael Griswold, Paul R Albert, Mireille Daigle, Jose J Miguel-Hidalgo, Mark C Austin, Randy D Blakely, David C Steffens, Craig A Stockmeier
Studies of major depressive disorder (MDD) in postmortem brain tissue report enhanced binding to inhibitory serotonin-1A autoreceptors in midbrain dorsal raphe and reductions in length of axons expressing the serotonin transporter (SERT) in dorsolateral prefrontal cortex. The length density of axons expressing SERT in the orbitofrontal cortex (OFC) was determined in 18 subjects with MDD and 17 age-matched control subjects. A monoclonal antibody was used to immunohistochemically label the SERT in fixed sections of OFC...
July 12, 2017: Neuroscience
https://www.readbyqxmd.com/read/28710424/takotsubo-syndrome-predictable-from-brain-imaging-data
#6
Carina Klein, Thierry Hiestand, Jelena-Rima Ghadri, Christian Templin, Lutz Jäncke, Jürgen Hänggi
Takotsubo syndrome (TTS) is characterized by acute left ventricular dysfunction, with a hospital-mortality rate similar to acute coronary syndrome (ACS). However, the aetiology of TTS is still unknown. In the present study, a multivariate pattern analysis using machine learning with multimodal magnetic resonance imaging (MRI) data of the human brain of TTS patients and age- and gender-matched healthy control subjects was performed. We found consistent structural and functional alterations in TTS patients compared to the control group...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28709915/sex-differences-in-somatic-and-sensory-motor-development-after-neonatal-anoxia-in-wistar-rats
#7
Amrita Jha Kumar, Silvia Honda Takada, Lívia Clemente Motta-Teixeira, Vitor Yonamine Lee, Gilberto Fernando Xavier, Maria Inês Nogueira
Currently, one of the important causes of brain injury in new-borns is the neonatal anoxia which impacts the perinatology services worldwide. Animal models of anoxia have been used to assess its effects at cellular and behavioural levels in all ages, but few studies focus on sex differences. This study aimed to investigate some physical parameters of development, sensorimotor alterations, early neurological reflexes as well as the density of cells in motor and sensorimotor cerebral cortex of adolescent rats submitted to neonatal anoxia...
July 12, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28709401/signal-transducer-and-activator-of-transcription-3-stat3-promoter-methylation-and-expression-in-pituitary-adenoma
#8
Indre Valiulyte, Giedrius Steponaitis, Daina Skiriute, Arimantas Tamasauskas, Paulina Vaitkiene
BACKGROUND: Pituitary adenoma (PA) is a benign brain tumor that can cause neurological, endocrinological and ophthalmological aberrations. Till now there is a need to identify factors that can influence the tumor invasiveness and recurrence. The aim of this study was to evaluate the associations between the signal transducer and activator of transcription 3 (STAT3) promoter methylation, mRNA expression and the invasiveness or recurrence of PAs and patient clinical characteristics. METHODS: Study participants comprised of 102 subjects with a diagnosis of PA: 54 functioning and 48 non-functioning, 58 invasive and 30 non-invasive PAs and 14 relapses...
July 14, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28709112/mens-inversus-in-corpore-inverso-language-lateralization-in-a-boy-with-situs-inversus-totalis
#9
Anna-Lisa Schuler, Gregor Kasprian, Ernst Schwartz, Rainer Seidl, Mariana C Diogo, Christian Mitter, Georg Langs, Daniela Prayer, Lisa Bartha-Doering
Situs inversus totalis is a rare condition where the visceral organs are organized as a mirror image of default organ position. In this study we picture the co-development between brain and visceral organs in a case of situs inversus totalis from a fetal stage to adolescence and compare our findings to an age-, gender-, and education-matched control with normal position of thoracic and abdominal organs. We show that in this case of situs inversus, functional and structural brain lateralization do not coincide with visceral organ situs...
July 11, 2017: Brain and Language
https://www.readbyqxmd.com/read/28707338/evaluation-of-interthalamic-adhesion-size-as-an-indicator-of-brain-atrophy-in-dogs-with-and-without-cognitive-dysfunction
#10
Daji Noh, Sooyoung Choi, Hojung Choi, Youngwon Lee, Kija Lee
Interthalamic adhesion thickness has been previously described as a parameter for quantifying canine brain atrophy and hypothesized to correlate with brain height or ventricular size. However, studies testing this hypothesis are lacking. This retrospective cross-sectional study aimed to compare interthalamic adhesion thickness, interthalamic adhesion thickness/brain height ratio, and interthalamic adhesion thickness/brain height ratio/lateral ventricle to brain height ratio values in dogs with and without cognitive dysfunction...
July 13, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28707062/when-an-object-appears-unexpectedly-foot-placement-during-obstacle-circumvention-in-children-and-adults-with-developmental-coordination-disorder
#11
K Wilmut, A L Barnett
Adjustments to locomotion to avoid an obstacle require a change to the usual pattern of foot placement, i.e. changes to step length and/or step width. Previous studies have demonstrated a difficulty in individuals with Developmental Coordination Disorder (DCD) in controlling stability while both stepping over and while circumventing an obstacle. In a previous study, we have considered the way in which individuals with DCD prepare for the possibility of an obstacle appearing (Wilmut and Barnett in Exp Brain Res 235:1531-1340, 2017)...
July 13, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28705699/posterolateral-trajectories-favor-a-longer-motor-domain-in-stn-dbs-for-parkinson-s-disease
#12
Idit Tamir, Odeya Marmor-Levin, Renana Eitan, Hagai Bergman, Zvi Israel
OBJECTIVE: The clinical outcome of Parkinson's disease (PD) patients that undergo Subthalamic Nucleus Deep Brain Stimulation (STN DBS) is, in part, determined by the length of the electrode trajectory through the motor STN domain, the Dorso-Lateral Oscillatory Region (DLOR). Trajectory length has been found to correlate with the stimulation-related improvement in patients' motor function (estimated by part III of the United Parkinson's Disease Rating Score (UPDRS)). Therefore, it seems that ideally trajectories should have maximal DLOR length...
July 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28702686/disparities-in-epilepsy-surgery-in-the-united-states-of-america
#13
Iván Sánchez Fernández, Christopher Stephen, Tobias Loddenkemper
The aim is to describe the epidemiology of epilepsy surgery in children and adults in the United States. We performed a descriptive study of the National Inpatient Sample (NIS) for the year 2012 and the Kids' Inpatient Database (KID) for the period 2010-2012, the largest all-payer databases on inpatient data in the USA. These databases estimate 97% of all inpatient hospital discharges in the USA. In the KID, 12,899 (0.2%) of admission records had brain surgery and 600 of the 4900 (12.2%) admissions with focal refractory epilepsy underwent epilepsy surgery...
July 12, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28700015/telomere-length-and-htert-in-mania-and-subsequent-remission
#14
Rugül Köse Çinar
Objective: The findings of telomere length (TL) studies in bipolar disorder (BD) are controversial. The aim of the present study was to detect TL, human telomerase reverse transcriptase (hTERT), and brain derived neurotrophic factor (BDNF) in severe mania and subsequent remission. Methods: Twenty-one medication-free male patients and 20 age and gender matched controls were recruited. The patients were followed in the inpatient clinic, and comparisons were made between the same patients in their remission state and controls...
July 6, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28699802/positive-correlation-between-blood-pressure-or-heart-rate-and-chymase-dependent-angiotensin-ii-forming-activity-in-circulating-mononuclear-leukocytes-measured-by-new-elisa
#15
Keisuke Okamura, Tetsu Okuda, Kazuyuki Shirai, Hidenori Urata
The aim of the present study was to establish a convenient clinically applicable assay method for chymase-dependent angiotensin II forming activity of circulating mononuclear leukocytes (CML), which was potentially a marker of tissue chymase activity. Using this method, association between CML chymase activity and clinical parameters was determined. Cardiovascular outpatients (n = 170) without taking antihypertensive medication were recruited. An ELISA for chymase-dependent angiotensin II-forming activity in CML was established using Nma /Dnp-modified angiotensin I...
July 12, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28695903/social-support-and-its-association-with-depression-gender-and-socioeconomic-indicators-in-individuals-with-spinal-cord-injury-in-iran
#16
Z Khazaeipour, M Hajiaghababaei, B Mirminachi, A R Vaccaro, V Rahimi-Movaghar
STUDY DESIGN: Descriptive cross-sectional study. OBJECTIVES: To investigate the relationship between perceived social support and depression and to evaluate the role of family, friends and other caregivers in the perception of social support in Iranian individuals with spinal cord injury (SCI). SETTING: Brain and Spinal Cord Injury Research Center, Tehran University of Medical Sciences, Tehran, Iran. METHODS: Social support was evaluated using the Multidimensional Scale of Perceived Social Support questionnaire, which gauges perceptions of support from family, friends and 'important persons'...
July 11, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28693158/relationship-between-mgmt-gene-expression-and-treatment-effectiveness-and-prognosis-in-glioma
#17
Qiang Li, Jiang Guo, Weisheng Wang, Dingkun Wang
The expression of O(6)-methylguanine DNA methyltransferase (MGMT) in different grade gliomas were analyzed in relation to its therapeutic effect and impact on disease prognosis. In total, 62 patients with glioma, who were admitted by neurosurgery and received surgical treatment and postoperative conventional chemoradiation, were selected for this study. Expression of MGMT was greater with an increase in brain glioma grade. Gender, age, tumor size and Karnofsky performance status (KPS) score did not differ with MGMT expression (P>0...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28690225/-grey-matter-concentration-revealed-by-voxel-based-morphometry-in-individuals-with-cognitive-vulnerability-to-depression
#18
Shuwen Yuan, Hui Lei, Shuqiao Yao, Xiaocui Zhang
To explore the grey matter concentration in individuals with cognitive vulnerability to depression.
 Methods: Thirty individuals with cognitive vulnerability to depression and thirty age- and gender-matched healthy controls were enrolled in this study, and they were subjected to magnetic resonance imaging (MRI) examination. The grey matter concentration differences were compared between the two groups by using voxel-based morphometry (VBM) following MRI.
 Results: Individuals with cognitive vulnerability to depression showed significantly lower grey matter density in bilateral insular, left cerebellum, right supplementary motor area, and left precentral gyrus than those in the healthy controls, while the healthy controls showed significantly lower grey density in the right inferior frontal gyrus, right middle frontal gyrus, and left cuneus than those in the individuals with cognitive vulnerability to depression...
June 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28689194/risk-factors-and-outcomes-associated-with-post-traumatic-headache-after-mild-traumatic-brain-injury
#19
Yilmaz Tansel, Gerwin Roks, Myrthe de Koning, Myrthe Scheenen, Harm van der Horn, Gerben Plas, Gerard Hageman, Guus Schoonman, Jacoba Spikman, Joukje van der Naalt
OBJECTIVES: To determine the prevalence and potential risk factors of acute and chronic post-traumatic headache (PTH) in patients with mild to moderate traumatic brain injury (TBI) in a prospective longitudinal observational multicentre study. Acute PTH (aPTH) is defined by new or worsening of pre-existing headache occurring within 7 days after trauma, whereas chronic PTH (cPTH) is defined as persisting aPTH >3 months after trauma. An additional goal was to study the impact of aPTH and cPTH in terms of return to work (RTW), anxiety and depression...
July 8, 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28688343/evidence-for-the-triadic-model-of-adolescent-brain-development-cognitive-load-and-task-relevance-of-emotion-differentially-affect-adolescents-and-adults
#20
Sven C Mueller, Sofie Cromheeke, Roma Siugzdaite, C Nicolas Boehler
In adults, cognitive control is supported by several brain regions including the limbic system and the dorsolateral prefrontal cortex (dlPFC) when processing emotional information. However, in adolescents, some theories hypothesize a neurobiological imbalance proposing heightened sensitivity to affective material in the amygdala and striatum within a cognitive control context. Yet, direct neurobiological evidence is scarce. Twenty-four adolescents (12-16) and 28 adults (25-35) completed an emotional n-back working memory task in response to happy, angry, and neutral faces during fMRI...
June 28, 2017: Developmental Cognitive Neuroscience
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