keyword
MENU ▼
Read by QxMD icon Read
search

moonlighting

keyword
https://www.readbyqxmd.com/read/29034753/ataxia-telangiectasia-syndrome-moonlighting-atm
#1
Majid Zaki Dizaji, Seyed Mohammad Akrami, Hassan Abolhassani, Nima Rezaei, Asghar Aghamohammadi
Ataxia-telangiectasia (A-T) a multisystem disorder primarily characterized by cerebellar degeneration, telangiectasia, immunodeficiency, cancer susceptibility and radiation sensitivity. Identification of the gene defective in this syndrome, ataxia-telangiectasia mutated gene (ATM), and further characterization of the disorder together with a greater insight into the function of the ATM protein have expanded our knowledge about the molecular pathogenesis of this disease. Area covered: In this review, we have attempted to summarize the different roles of ATM signaling that have provided new insights into the diverse clinical phenotypes exhibited by A-T patients...
October 16, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29034216/a-new-trick-for-a-conserved-enzyme-mevalonate-kinase-a-glycosomal-enzyme-can-be-secreted-by-trypanosoma-cruzi-and-modulate-cell-invasion-and-signaling-is-it-another-moonlighting-enzyme
#2
https://www.readbyqxmd.com/read/29027792/multifunctional-cytochrome-c-learning-new-tricks-from-an-old-dog
#3
Damián Alvarez-Paggi, Luciana Hannibal, María A Castro, Santiago Oviedo-Rouco, Veronica Demicheli, Veronica Tórtora, Florencia Tomasina, Rafael Radi, Daniel H Murgida
Cytochrome c (cyt c) is a small soluble heme protein characterized by a relatively flexible structure, particularly in the ferric form, such that it is able to sample a broad conformational space. Depending on the specific conditions, interactions, and cellular localization, different conformations may be stabilized, which differ in structure, redox properties, binding affinities, and enzymatic activity. The primary function is electron shuttling in oxidative phosphorylation, and is exerted by the so-called native cyt c in the intermembrane mitochondrial space of healthy cells...
October 13, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/29027223/inflammatory-cell-death-in-intestinal-pathologies
#4
REVIEW
Deepika Sharma, Thirumala-Devi Kanneganti
The intestinal tract is a site of intense immune cell activity that is poised to mount an effective response against a pathogen and yet maintain tolerance toward commensal bacteria and innocuous dietary antigens. The role of cell death in gut pathologies is particularly important as the intestinal epithelium undergoes self-renewal every 4-7 days through a continuous process of cell death and cell division. Cell death is also required for removal of infected, damaged, and cancerous cells. Certain forms of cell death trigger inflammation through release of damage-associated molecular patterns...
November 2017: Immunological Reviews
https://www.readbyqxmd.com/read/29020114/how-annual-course-of-photoperiod-shapes-seasonal-behavior-of-diploid-and-triploid-oysters-crassostrea-gigas
#5
Laura Payton, Mohamedou Sow, Jean-Charles Massabuau, Pierre Ciret, Damien Tran
In this work, we study if ploidy (i.e. number of copies of chromosomes) in the oyster Crassostrea gigas may introduce differences in behavior and in its synchronization by the annual photoperiod. To answer to the question about the effect of the seasonal course of the photoperiod on the behavior of C. gigas according to its ploidy, we quantified valve activity by HFNI valvometry in situ for 1 year in both diploid and triploid oysters. Chronobiological analyses of daily, tidal and lunar rhythms were performed according the annual change of the photoperiod...
2017: PloS One
https://www.readbyqxmd.com/read/28982698/pyruvate-dehydrogenase-complex-pdc-subunits-moonlight-as-interaction-partners-of-phosphorylated-stat5-in-adipocytes-and-adipose-tissue
#6
Allison J Richard, Hardy Hang, Jacqueline M Stephens
STAT5 proteins play a role in adipocyte development and function, but their specific functions are largely unknown. To this end, we used an unbiased MS-based approach to identify novel STAT5-interacting proteins. We observed that STAT5A bound the E1β and E2 subunits of the pyruvate dehydrogenase complex (PDC). Whereas STAT5A typically localizes to the cytosol or nucleus, PDC normally resides within the mitochondrial matrix where it converts pyruvate to acetyl-CoA. We employed affinity purification and immunoblotting to validate the interaction between STAT5A and PDC subunits in murine and human cultured adipocytes, as well as in adipose tissue...
October 5, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28981755/rice-nad-dependent-histone-deacetylase-ossrt1-represses-glycolysis-and-regulates-the-moonlighting-function-of-gapdh-as-a-transcriptional-activator-of-glycolytic-genes
#7
Hua Zhang, Yu Zhao, Dao-Xiu Zhou
Sirtuins, a family of proteins with homology to the yeast silent information regulator 2 (Sir2), are NAD+-dependent histone deacetylases and play crucial roles in energy sensing and regulation in yeast and animal cells. Plants are autotrophic organisms and display distinct features of carbon and energy metabolism. It remains largely unexplored whether and how plant cells sense energy/redox status to control carbon metabolic flux under various growth conditions. In this work, we show that the rice nuclear sirtuin OsSRT1 not only functions as an epigenetic regulator to repress glycolytic genes expression and glycolysis in seedlings, but also inhibits transcriptional activity of glyceraldehyde-3-phosphatedehydrogenase (GAPDH) that is enriched on glycolytic genes promoters and stimulates their expression...
September 13, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28969870/samhd1-sheds-moonlight-on-dna-double-strand-break-repair
#8
Maria Jose Cabello-Lobato, Siyue Wang, Christine Katrin Schmidt
SAMHD1 (sterile α motif and histidine (H) aspartate (D) domain-containing protein 1) is known for its antiviral activity of hydrolysing deoxynucleotides required for virus replication. Daddacha et al. identify a hydrolase-independent, moonlighting function of SAMHD1 that facilitates homologous recombination of DNA double-strand breaks (DSBs) by promoting recruitment of C-terminal binding protein interacting protein (CTIP), a DNA-end resection factor, to damaged DNA. These findings could benefit anticancer treatment...
September 29, 2017: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/28965762/a-population-representation-of-absolute-light-intensity-in-the-mammalian-retina
#9
Elliott Scott Milner, Michael Tri Hoang Do
Environmental illumination spans many log units of intensity and is tracked for essential functions that include regulation of the circadian clock, arousal state, and hormone levels. Little is known about the neural representation of light intensity and how it covers the necessary range. This question became accessible with the discovery of mammalian photoreceptors that are required for intensity-driven functions, the M1 ipRGCs. The spike outputs of M1s are thought to uniformly track intensity over a wide range...
September 27, 2017: Cell
https://www.readbyqxmd.com/read/28960389/the-other-face-of-an-editor-adar1-functions-in-editing-independent-ways
#10
REVIEW
Konstantin Licht, Michael F Jantsch
The RNA editing enzyme ADAR1 seemingly has more functions besides RNA editing. Mouse models lacking ADAR1 and sensors of foreign RNA show that RNA editing by ADAR1 plays a crucial role in the innate immune response. Still, RNA editing alone cannot explain all observed phenotypes. Thus, additional roles for ADAR1 must exist. Binding of ADAR1 to RNA is independent of its RNA editing function. Thus, ADAR1 may compete with other RNA-binding proteins. A very recent manuscript elaborates on this and reports competition of ADAR1 with STAUFEN1, thereby modulating RNA-degradation...
September 28, 2017: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/28947287/moonlighting-policies-among-us-dermatology-residency-programs-a-survey
#11
Kishore L Jayakumar, Jules B Lipoff
No abstract text is available yet for this article.
September 22, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28938577/mitochondria-chaperone-grp75-moonlighting-as-a-cell-cycle-controller-to-derail-endocytosis-provides-an-opportunity-for-nanomicrosphere-intracellular-delivery
#12
Zhihui Gao, Xiuran Niu, Qing Zhang, Hang Chen, Aiai Gao, Shanshan Qi, Rong Xiang, Mattias Belting, Sihe Zhang
Understanding how cancer cells regulate endocytosis during the cell cycle could lead us to capitalize this event pharmacologically. Although certain endocytosis pathways are attenuated during mitosis, the endocytosis shift and regulation during the cell cycle have not been well clarified. The conventional concept of glucose-regulated proteins (GRPs) as protein folding chaperones was updated by discoveries that translocated GRPs assume moonlighting functions that modify the immune response, regulate viral release, and control intracellular trafficking...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28923966/amazon-plant-diversity-revealed-by-a-taxonomically-verified-species-list
#13
Domingos Cardoso, Tiina Särkinen, Sara Alexander, André M Amorim, Volker Bittrich, Marcela Celis, Douglas C Daly, Pedro Fiaschi, Vicki A Funk, Leandro L Giacomin, Renato Goldenberg, Gustavo Heiden, João Iganci, Carol L Kelloff, Sandra Knapp, Haroldo Cavalcante de Lima, Anderson F P Machado, Rubens Manoel Dos Santos, Renato Mello-Silva, Fabián A Michelangeli, John Mitchell, Peter Moonlight, Pedro Luís Rodrigues de Moraes, Scott A Mori, Teonildes Sacramento Nunes, Terry D Pennington, José Rubens Pirani, Ghillean T Prance, Luciano Paganucci de Queiroz, Alessandro Rapini, Ricarda Riina, Carlos Alberto Vargas Rincon, Nádia Roque, Gustavo Shimizu, Marcos Sobral, João Renato Stehmann, Warren D Stevens, Charlotte M Taylor, Marcelo Trovó, Cássio van den Berg, Henk van der Werff, Pedro Lage Viana, Charles E Zartman, Rafaela Campostrini Forzza
Recent debates on the number of plant species in the vast lowland rain forests of the Amazon have been based largely on model estimates, neglecting published checklists based on verified voucher data. Here we collate taxonomically verified checklists to present a list of seed plant species from lowland Amazon rain forests. Our list comprises 14,003 species, of which 6,727 are trees. These figures are similar to estimates derived from nonparametric ecological models, but they contrast strongly with predictions of much higher tree diversity derived from parametric models...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28904819/prdx6-retards-senescence-and-restores-trabecular-meshwork-cell-health-by-regulating-reactive-oxygen-species
#14
Bhavana Chhunchha, Prerna Singh, W Daniel Stamer, Dhirendra P Singh
A progressive decline in antioxidant potential and accumulation of reactive oxygen species (ROS) are major causes of pathogenesis of several diseases, including glaucoma. Trabecular meshwork (TM) dysfunction resulting in higher intraocular pressure (IOP) is a hallmark of glaucoma, but its causes are unclear. Using human (h) TM cells derived from glaucomatous and normal subjects of different ages and cells facing oxidative-stress, we showed that specific loss of moonlighting antioxidant protein Peroxiredoxin (Prdx) 6 in aging or in glaucomatous TM cells caused ROS accumulation and pathobiological changes in TM cells...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28894125/elongation-factor-tu-is-a-multifunctional-and-processed-moonlighting-protein
#15
Michael Widjaja, Kate Louise Harvey, Lisa Hagemann, Iain James Berry, Veronica Maria Jarocki, Benjamin Bernard Armando Raymond, Jessica Leigh Tacchi, Anne Gründel, Joel Ricky Steele, Matthew Paul Padula, Ian George Charles, Roger Dumke, Steven Philip Djordjevic
Many bacterial moonlighting proteins were originally described in medically, agriculturally, and commercially important members of the low G + C Firmicutes. We show Elongation factor Tu (Ef-Tu) moonlights on the surface of the human pathogens Staphylococcus aureus (SaEf-Tu) and Mycoplasma pneumoniae (MpnEf-Tu), and the porcine pathogen Mycoplasma hyopneumoniae (MhpEf-Tu). Ef-Tu is also a target of multiple processing events on the cell surface and these were characterised using an N-terminomics pipeline...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28888424/novel-patient-missense-mutations-in-the-hsd17b10-gene-affect-dehydrogenase-and-mitochondrial-trna-modification-functions-of-the-encoded-protein
#16
Stephanie Oerum, Martine Roovers, Michael Leichsenring, Cécile Acquaviva-Bourdain, Frauke Beermann, Corinne Gemperle-Britschgi, Alain Fouilhoux, Anne Korwitz-Reichelt, Henry J Bailey, Louis Droogmans, Udo Oppermann, Jörn Oliver Sass, Wyatt W Yue
MRPP2 (also known as HSD10/SDR5C1) is a multifunctional protein that harbours both catalytic and non-catalytic functions. The protein belongs to the short-chain dehydrogenase/reductases (SDR) family and is involved in the catabolism of isoleucine in vivo and steroid metabolism in vitro. MRPP2 also moonlights in a complex with the MRPP1 (also known as TRMT10C) protein for N1-methylation of purines at position 9 of mitochondrial tRNA, and in a complex with MRPP1 and MRPP3 (also known as PRORP) proteins for 5'-end processing of mitochondrial precursor tRNA...
September 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28881966/dextmp-deep-dive-into-text-for-predicting-moonlighting-proteins
#17
Ishita K Khan, Mansurul Bhuiyan, Daisuke Kihara
Motivation: Moonlighting proteins (MPs) are an important class of proteins that perform more than one independent cellular function. MPs are gaining more attention in recent years as they are found to play important roles in various systems including disease developments. MPs also have a significant impact in computational function prediction and annotation in databases. Currently MPs are not labeled as such in biological databases even in cases where multiple distinct functions are known for the proteins...
July 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28877029/impairments-in-age-dependent-ubiquitin-proteostasis-and-structural-integrity-of-selective-neurons-by-uncoupling-ran-gtpase-from-the-ran-binding-domain-3-of-ranbp2-and-identification-of-novel-mitochondrial-isoforms-of-ubiquitin-conjugating-enzyme-e2i-ubc9-and
#18
Hemangi Patil, Dosuk Yoon, Reshma Bhowmick, Yunfei Cai, Kyoung-In Cho, Paulo A Ferreira
The Ran-binding protein 2 (Ranbp2/Nup358) is a cytoplasmic and peripheral nucleoporin comprised of 4 Ran-GTP-binding domains (RBDs) that are interspersed among diverse structural domains with multifunctional activities. Our prior studies found that the RBD2 and RBD3 of Ranbp2 control mitochondrial motility independently of Ran-GTP-binding in cultured cells, whereas loss of Ran-GTP-binding to RBD2 and RBD3 are essential to support cone photoreceptor development and the survival of mature retinal pigment epithelium (RPE) in mice...
September 6, 2017: Small GTPases
https://www.readbyqxmd.com/read/28861445/data-regarding-the-growth-of-lactobacillus-acidophilus-ncfm-on-different-carbohydrates-and-recombinant-production-of-elongation-factor-g-and-pyruvate-kinase
#19
Hasan Ufuk Celebioglu, Sita Vaag Olesen, Kennie Prehn, Sampo J Lahtinen, Susanne Brix, Maher Abou Hachem, Birte Svensson
The present study describes the growth of the very well-known probiotic bacterium Lactobacillus acidophilus NCFM on different carbohydrates. Furthermore, recombinant production of putative moonlighting proteins elongation factor G and pyruvate kinase from this bacterium is described. For further and detailed interpretation of the data presented here, please see the research article "Mucin- and carbohydrate-stimulated adhesion and subproteome changes of the probiotic bacterium Lactobacillus acidophilus NCFM" (Celebioglu et al...
October 2017: Data in Brief
https://www.readbyqxmd.com/read/28854803/protein-composition-of-the-phase-i-coxiella-burnetii-soluble-antigen-prepared-by-extraction-with-trichloroacetic-acid
#20
G Flores-Ramírez, M Kmeťová, M Danchenko, E Špitalská, V Havlíček, Ľ Škultéty
Q fever is a highly infectious, widespread airborne zoonosis caused by Coxiella burnetii bacterium. Humans usually acquire the disease by inhalation of contaminated aerosol produced by infected livestock. Vaccination is the most practical way for prevention and control of the disease in the exposed population. In this work, we reviewed the most important Q-fever outbreaks in Slovakia as well as the progress in vaccine development. One of them represents a soluble antigen complex produced by extraction with trichloroacetic acid from a highly purified C...
2017: Acta Virologica
keyword
keyword
115295
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"