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https://www.readbyqxmd.com/read/29136782/effect-of-human-umbilical-cord-blood-derived-mononuclear-cells-on-diabetic-nephropathy-in-rats
#1
Nahla E El-Ashmawy, Eman G Khedr, Hoda A El-Bahrawy, Shimaa A El-Berashy
Diabetic nephropathy (DN) is damage to the kidney which can lead to chronic renal failure, eventually requiring dialysis. Diabetes mellitus is the most common cause of adult kidney failure worldwide in the developed world. The current work was designed to elucidate the effect of mononuclear cells (MNCs) injection on reverse DN in rats exposed to streptozotocin (STZ) injection compared to metformin as a known hypoglycemic drug, 40 Male rats were divided equally into 4 groups; normal control group, diabetic control group, MNCs group were diabetic rats treated with MNCs (30×10(6) MNCs/rat once iv dose) in the tail vein of the rat, and metformin group were diabetic rats treated with metformin (100mg/kg orally daily dose) for four weeks...
November 8, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29105530/the-relationship-between-il-18-and-atherosclerotic-cardiovascular-risk-in-egyptian-lean-women-with-polycystic-ovary-syndrome
#2
Alaaeldin Dawood, Nabil Alkafrawy, Said Saleh, Rasha Noreldin, Shimaa Zewain
BACKGROUND: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder among women of reproductive age. The evidence in support of low-grade inflammation in PCOS as an etiology is emerging. Inflammation is likely to be associated with other prominent aspects of PCOS including insulin resistance (IR) and cardiovascular disease (CVD) risk. Interleukin-18 (IL-18) is considered as a strong marker of inflammation. OBJECTIVES: Evaluation of the relation between serum IL-18 and atherosclerotic CVD (ASCVD) risk in Egyptian lean females with PCO...
November 5, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29096367/electrochemical-immunosensors-for-the-detection-of-survival-motor-neuron-smn-protein-using-different-carbon-nanomaterials-modified-electrodes
#3
Shimaa Eissa, Nawal Alshehri, Anas M Abdel Rahman, Majed Dasouki, Khalid M Abu Salah, Mohammed Zourob
Spinal muscular atrophy is an untreatable potentially fatal hereditary disorder caused by loss-of-function mutations in the survival motor neuron (SMN) 1 gene which encodes the SMN protein. Currently, definitive diagnosis relies on the demonstration of biallelic pathogenic variants in SMN1 gene. Therefore, there is an urgent unmet need to accurately quantify SMN protein levels for screening and therapeutic monitoring of symptomatic newborn and SMA patients, respectively. Here, we developed a voltammetric immunosensor for the sensitive detection of SMN protein based on covalently functionalized carbon nanofiber-modified screen printed electrodes...
October 10, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29091907/synthesis-molecular-electronic-structure-linear-and-non-linear-optical-and-phototransient-properties-of-8-methyl-1-2-dihydro-4h-chromeno-2-3-b-quinoline-4-6-3h-dione-mdcqd-experimental-and-dft-investigations
#4
A A M Farag, N Roushdy, Shimaa Abdel Halim, Nasser M El-Gohary, Magdy A Ibrahim, Sara Said
Base catalysed ring opening ring closure (RORC) reaction of 6-methylchromone-3‑carbonitrile (1) with 1,3-cyclohexanedione afforded 8-methyl-1,2-dihydro-4H-chromeno[2,3-b]quinoline-4,6(3H)-dione (MDCQD). Theoretical calculations by Density Functional Theory (DFT) at the B3LYP/6-311G (d,p) level of theory was utilized to illustrate the equilibrium geometries of MDCQD. Also, the nonlinear optical properties, simple harmonic vibrational frequencies, thermo-chemical parameters and Mullikan atomic charges were calculated...
October 5, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29038534/performance-and-consistency-of-a-fluorescence-based-high-throughput-screening-assay-for-use-in-babesia-drug-screening-in-mice
#5
Mohamed Abdo Rizk, Shimaa Abd El-Salam El-Sayed, Mahmoud AbouLaila, Rasha Eltaysh, Naoaki Yokoyama, Ikuo Igarashi
In this study, we evaluated the validity of a fluorescence-based assay using SYBR Green I (SG I) stain for screening antibabesial compounds against B. microti in mice. Two different hematocrits (HCTs; 2.5% and 5%) were used. Correlating relative fluorescence units (RFUs) with parasitemia showed significant linear relationships with R(2) values of 0.97 and 0.99 at HCTs of 2.5% and 5%, respectively. Meanwhile, the Z' factors in a high-throughput screening (HTS) assay were within the permissible limit (≥0.5) at 2...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29035848/animal-level-risk-factors-associated-with-babesia-and-theileria-infections-in-cattle-in-egypt
#6
Mohamed Abdo Rizk, Akram Salama, Shimaa Abd-El-Salam El-Sayed, Ahmed Elsify, Maged El-Ashkar, Hussam Ibrahim, Mohamed Youssef, Sabry El-Khodery
In present study, blood samples were collected randomly from 439 cows at three main regions of Egypt (northern, central and southern). Molecular diagnosis of Babesia and Theileria infections by PCR amplification of DNA (gene) fragments, then cloning and sequencing of the positive samples were conducted. A questionnaire was created to imply the assumed risk factors and logistic regression statistical analysis was carried out to appraise the potential factors on the animal level. The results revealed that 49 (11...
December 20, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/29029900/teixobactin-as-a-scaffold-for-unlimited-new-antimicrobial-peptides-sar-study
#7
Shimaa A H Abdel Monaim, Yahya E Jad, Ayman El-Faham, Beatriz G de la Torre, Fernando Albericio
It looks that a new era of antimicrobial peptides (AMPs) started with the discovery of teixobactin, which is a "head to side-chain" cyclodepsipeptide. It was isolated from a soil gram-negative b-proteobacteria by means of a revolutionary technique. Since there, several groups have developed synthetic strategies for efficient synthesis of this peptide and its analogues as well. Herein, all chemistries reported as well as the biological activity of the analogues are analyzed. Finally, some inputs regarding new trends for the next generation of analogues are discussed...
September 30, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28974454/sildenafil-protects-against-bile-duct-ligation-induced-hepatic-fibrosis-in-rats-potential-role-for-silent-information-regulator-1-sirt1
#8
Dalia M Abd El Motteleb, Islam A A E-H Ibrahim, Shimaa M Elshazly
Hepatic fibrosis is a potential health problem that may end with life-threatening cirrhosis and primary liver cancer. Recent studies point out to the protective effects of silent information regulator1 (SIRT1), against different models of organs fibrosis. This work aimed to investigate the possible protective effect of sildenafil (SIRT1 activator) against hepatic fibrosis induced by bile duct ligation (BDL). Firstly, three different doses of sildenafil (5, 10, 20mg/kg/day) were investigated; to detect the most protective one against BDL induced liver dysfunction and hepatic fibrosis...
November 15, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28963634/intra-articular-methotrexate-versus-corticosteroid-injections-in-medium-sized-joints-of-rheumatoid-arthritis-patients-an-intervention-study
#9
Mohmad Attia Mortada, Shimaa Mustafa Abdelwhab, Mohmad H Elgawish
The effects of intra-articular methotrexate (I/A MTX) in knee synovitis in rheumatoid arthritis have been previously evaluated. I/A MTX has not been studied in other joints. Ultrasonography (US) has been little studied in monitoring the effect of I/A MTX. The aim of the study is to test the efficacy of I/A MTX in suppression of persistent synovitis in medium-sized joints (ankle, wrist, and elbow) in rheumatoid arthritis patients. Patients were divided into two groups: group 1 (methotrexate group): 56 patients in which 84 joints (32 ankles, 28 wrists, and 24 elbows) were injected intra-articularly by 10 mg of methotrexate in the targeted joint on a weekly basis for 8 weeks and group 2 (steroid group): 44 patients in which 70 joints (26 ankles, 24 wrists, and 20 elbows) were injected once by Triamcinolone acetonide 40 mg...
September 30, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28956840/investigation-of-the-n-terminus-amino-function-of-arg10-teixobactin
#10
Shimaa A H Abdel Monaim, Sikabwe Noki, Estelle J Ramchuran, Ayman El-Faham, Fernando Albericio, Beatriz G de la Torre
Teixobactin is a recently described antimicrobial peptide that shows high activity against gram-positive bacteria as well as mycobacterium tuberculosis. Due to both its structure as a head-to-side chain cyclodepsipeptide and its activity, it has attracted the attention of several research groups. In this regard, a large number of analogs with substitutions in both the cycle and the tail has been described. Here, we report the contribution of the N-terminus residue, N-Me-d-Phe, to the activity of Arg10-teixobactin...
September 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28912324/permanent-draft-genome-sequence-of-photorhabdus-temperata-strain-hm-an-entomopathogenic-bacterium-isolated-from-nematodes
#11
Shimaa Ghazal, Erik Swanson, Stephen Simpson, Krystalynne Morris, Feseha Abebe-Akele, W Kelley Thomas, Kamal M Khalil, Louis S Tisa
Photorhabdus temperata strain Hm is an entomopathogenic bacterium that forms a symbiotic association with Heterorhabditis nematodes. Here, we report a 5.0-Mbp draft genome sequence for P. temperata strain Hm with a G+C content of 44.1% and containing 4,226 candidate protein-encoding genes.
September 14, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28888656/molecular-characterization-of-circulating-foot-and-mouth-disease-virus-fmdv-serotype-o-topotype-ea-3-and-serotype-a-african-topotype-genotype-iv-in-egypt-2016
#12
Mohamed A Soltan, Ali H Negmaldin, Mohamed M El-Diasty, Shimaa M G Mansour, Maha A Elbadry, Rebecca P Wilkes
In January-April 2016, cattle and buffalo farm owners and veterinarians reported clinical signs suggestive of foot and mouth disease virus (FMDV) outbreaks among non-vaccinated cattle and buffalo herds in Egypt. The clinical disease observed was either mild (small oral lesions and speedy recovery) or severe (extensive oral lesions and/or mortalities), and the form of the disease (either mild or severe) segregated by farm. This study aimed to confirm the presence of FMDV and to characterize the circulating strains associated with the outbreaks...
September 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28841783/zinc-oxide-nanoparticle-toxicity-in-embryonic-zebrafish-mitigation-with-different-natural-organic-matter
#13
Shimaa M Kteeba, Hala I El-Adawi, Osman A El-Rayis, Ahmed E El-Ghobashy, Jessica L Schuld, Kurt R Svoboda, Laodong Guo
Exposure experiments were conducted to evaluate the influence of dissolved organic matter (DOM) on the toxicity of ZnO-NPs (10-30 nm) and dissolved Zn at sub-lethal doses (50 and 5 ppm, respectively) to zebrafish (Danio rerio). Humic acid, alginic acid, bovine serum albumin and various natural DOM isolated from rivers as the Milwaukee River-WI (NOMW), Yukon River-AK (NOMA) and Suwannee River-GA DOM (NOMS) were used to represent humic substances (HA), carbohydrates (CHO), proteins (PTN), and natural organic matter (NOM), respectively...
November 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28836639/titanium-nanoparticles-tio2-graphene-oxide-nanosheets-go-an-electrochemical-sensing-platform-for-the-sensitive-and-simultaneous-determination-of-benzocaine-in-the-presence-of-antipyrine
#14
Mona A Mohamed, Shimaa A Atty, Hanan A Merey, Taghreed A Fattah, Christopher W Foster, Craig E Banks
An effective electrochemical sensing platform for the simultaneous determination of benzocaine (BEN) and antipyrine (ANT) based upon titanium dioxide nanoparticle (TiO2)/graphene oxide nanosheet (GO) bulk modified carbon paste electrodes (TiO2-GO/CPE) is reported. The TiO2-GO/CPE electrochemical sensing platform is found to exhibit linear ranges from 1.0 × 10(-6) to 1.0 × 10(-4) M and 1.2 × 10(-8) to 8.0 × 10(-5) M for BEN and ANT, respectively. The TiO2-GO/CPE sensor is explored towards the analysis of BEN and ANT in oral fluid (saliva) and pharmaceutical products...
October 7, 2017: Analyst
https://www.readbyqxmd.com/read/28832071/prognostic-value-of-twist-1-e-cadherin-and-ezh2-in-prostate-cancer-an-immunohistochemical-study
#15
Aziza E Abdelrahman, Shimaa A Arafa, Ragab A Ahmed
OBJECTIVE: There is an urgent need to identify molecular biomarkers rather than clinical markers to distinguish aggressive prostate cancer from the indolent majority for proper treatment and accurate prediction of prognosis. We aimed to investigate the immunohistochemical expression of epithelial-mesenchymal transition (EMT)-related molecules (Twist-1 and E-cadherin) and the stem cell marker EZH2 in prostate cancer and to assess their ability to identify the high-risk patients, in a trial to explore their prognostic implications...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28831754/comparative-therapeutic-effect-of-steroidal-and-non-steroidal-anti-inflammatory-drugs-on-pro-inflammatory-cytokine-production-in-water-buffalo-calves-bubalus-bubalis-naturally-infected-with-bronchopneumonia-a-randomized-clinical-trial
#16
Mohamed Abdo Rizk, Motamed Elsayed Mahmoud, Shimaa Abd El-Salam El-Sayed, Doaa Salman
In the current study, we compared the therapeutic effects of a non-steroidal and a steroidal anti-inflammatory drug on the production of pro-inflammatory cytokines, interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-12p40 (IL-12p40), interferon gamma (IFNγ), and tumor necrosis factor alpha (TNF-α) in the blood of water buffalo (Bubalus bubalis) calves naturally infected by bronchopneumonia. Twenty-seven buffalo calves (7 ± 2-month-old, 163 ± 12 kg) reared in smallholder farms in El-Dakahlia province in Egypt were identified to have bronchopneumonia and randomly allocated into three equal groups...
August 22, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28831220/serotyping-antibiotic-susceptibility-and-virulence-genes-screening-of-escherichia-coli-isolates-obtained-from-diarrheic-buffalo-calves-in-egyptian-farms
#17
Ashraf S Hakim, Shimaa T Omara, Sohier M Syame, Ehab A Fouad
AIM: In Egypt as in many other countries, river water buffalo (Bubalus bubalis) is considered an important source of high-quality milk and meat supply. The objective of this study was to investigate serotypes, virulence genes, and antibiotic resistance determinants profiles of Escherichia coli isolated from buffalo at some places in Egypt; noticibly, this issue was not discussed in the country yet. MATERIALS AND METHODS: A number of 58 rectal samples were collected from diarrheic buffalo calves in different regions in Egypt, and bacteriological investigated for E...
July 2017: Veterinary World
https://www.readbyqxmd.com/read/28808805/molecular-factors-regulating-e-cadherin-expression-in-urothelial-bladder-cancer-and-their-correlations-with-the-clinicopathological-features
#18
Samia Hussein, Hala Mosaad, Hayam E Rashed, Shimaa Ahmed, Ahmed Ragab, Eman I Ismail
This study aimed to assess the expression of S100A4, Twist and E-cadherin (mRNA and protein) in urothelial bladder cancer, investigate the correlation between them and evaluate their association with the clinicopathological features of the disease. The study included 54 patients diagnosed as urothelial bladder cancer of different stages and grades. The expression levels of S100A4, Twist and E-cadherin (mRNA and protein) in tissue samples were determined by quantitative RT-PCR and immunohistochemistry. The expression of S100A4 and Twist was significantly upregulated while E- cadherin was significantly downregulated in urothelial bladder cancer tissues compared to the adjacent surrounding normal bladder tissues at both mRNA and protein levels (p < 0...
August 2017: Molecular Biology Reports
https://www.readbyqxmd.com/read/28795806/converting-teixobactin-into-a-cationic-antimicrobial-peptide-amp
#19
Shimaa A H Abdel Monaim, Estelle J Ramchuran, Ayman El-Faham, Fernando Albericio, Beatriz G de la Torre
Teixobactin is a head to side chain cyclodepsipeptide that contains two positive charges. One is found in the cycle, as a result of the presence of the guanidino-unusual amino acid L-allo-End, while the other is at the N-terminal. Here we introduce 26 new Teixobactin analogues with an increasing number of positive charges. In an attempt to fine-tune the biological activity of Teixobactin, we examined the effect of cationicity on the SAR of these analogues. The maximum number of positive charges to maintain the activity are three to four...
September 14, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28764171/evaluation-of-hypoxia-inducible-factor-1%C3%AE-and-glucose-transporter-1-expression-in-non-melanoma-skin-cancer-an-immunohistochemical-study
#20
Iman Seleit, Ola Ahmed Bakry, Dalia Rifaat Al-Sharaky, Rania Abdel Aziz Ragab, Shimaa Ahmed Al-Shiemy
INTRODUCTION: Hypoxia Inducible Factor-1 (HIF-1) is a mediator enabling cell adaptation to hypoxia. It plays its role mainly through transcription of many target genes including Glucose Transporter-1 (GLUT-1) gene. AIM: The present work aimed at evaluating the pattern and distribution of HIF-1α and GLUT-1 in each case and control. MATERIALS AND METHODS: A case-control and retrospective study was conducted on archival blocks diagnosed from pathology department as, Basal Cell Carcinoma (BCC, 20 cases), cutaneous Squamous Cell Carcinoma (SCC, 20 cases) and 20 normal site-matched skin biopsies from age and gender-matched healthy subjects as a control...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
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