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https://www.readbyqxmd.com/read/28795806/converting-teixobactin-into-a-cationic-antimicrobial-peptide-amp
#1
Shimaa A H Abdel Monaim, Estelle J Ramchuran, Ayman El-Faham, Fernando Albericio, Beatriz G de la Torre
Teixobactin is a head to side chain cyclodepsipeptide that contains two positive charges. One is found in the cycle, as a result of the presence of the guanidino-unusual amino acid L-allo-End, while the other is at the N-terminal. Here we introduce 26 new Teixobactin analogues with an increasing number of positive charges. In an attempt to fine-tune the biological activity of Teixobactin, we examined the effect of cationicity on the SAR of these analogues. The maximum number of positive charges to maintain the activity are three-four...
August 10, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28764171/evaluation-of-hypoxia-inducible-factor-1%C3%AE-and-glucose-transporter-1-expression-in-non-melanoma-skin-cancer-an-immunohistochemical-study
#2
Iman Seleit, Ola Ahmed Bakry, Dalia Rifaat Al-Sharaky, Rania Abdel Aziz Ragab, Shimaa Ahmed Al-Shiemy
INTRODUCTION: Hypoxia Inducible Factor-1 (HIF-1) is a mediator enabling cell adaptation to hypoxia. It plays its role mainly through transcription of many target genes including Glucose Transporter-1 (GLUT-1) gene. AIM: The present work aimed at evaluating the pattern and distribution of HIF-1α and GLUT-1 in each case and control. MATERIALS AND METHODS: A case-control and retrospective study was conducted on archival blocks diagnosed from pathology department as, Basal Cell Carcinoma (BCC, 20 cases), cutaneous Squamous Cell Carcinoma (SCC, 20 cases) and 20 normal site-matched skin biopsies from age and gender-matched healthy subjects as a control...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28763751/berberine-ameliorates-methotrexate-induced-liver-injury-by-activating-nrf2-ho-1-pathway-and-ppar%C3%AE-and-suppressing-oxidative-stress-and-apoptosis-in-rats
#3
Ayman M Mahmoud, Walaa G Hozayen, Shimaa M Ramadan
Berberine (BBR) is a natural isoquinoline alkaloid with very impressive health benefits. It is one of the most effective natural supplements available; however, its ameliorative mechanism against methotrexate (MTX)-induced liver injury is not well defined. This study investigated the protective effect of BBR against MTX hepatotoxicity, focusing on its ability to attenuate oxidative stress and apoptosis and to activate nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling and peroxisome proliferator activated receptor gamma (PPARγ)...
July 29, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28758172/erratum-to-screening-of-blood-levels-of-mercury-cadmium-and-copper-in-pregnant-women-in-dakahlia-egypt-new-attention-to-an-old-problem
#4
Shimaa M Motawei, Hossam E Gouda
No abstract text is available yet for this article.
July 31, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28752960/after-successful-hepatitis-c-virus-antiviral-therapy-it-looks-that-normal-alanine-aminotransferase-level-is-not-the-normal
#5
Mohamed El Kassas, Mohamed Alboraie, Aya Mostafa, Reem Ezzat, Adel El Tahan, Shimaa Afify, Ahmed Sweedy, Ibrahim Kabbash, Gamal Esmat
BACKGROUND: Normal serum alanine aminotransferase (ALT) levels differ with age, gender, and body mass index. Adjusting the upper limits of normal (ULN) for ALT needs further research in different populations. Aim of this work was to monitor the effect of successful chronic hepatitis C (CHC) treatment on the ALT levels in patients with normal pretreatment ALT. METHODS: Data of 1160 CHC patients with persistent pretreatment normal liver enzymes were retrospectively analyzed...
July 28, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28743470/molecular-identification-and-antigenic-characterization-of-babesia-divergens-erythrocyte-binding-protein-bdebp-as-a-potential-vaccine-candidate
#6
Shimaa Abd El-Salam El-Sayed, Mohamed Abdo Rizk, Mohamad Alaa Terkawi, Naoaki Yokoyama, Ikuo Igarashi
Host cell invasion is the only step where Babesia parasites are extracellular, and their survival is menaced during this step. Therefore, interfering with this critical stage is a target for an anti-Babesia intervention strategy. In this regard, recombinant protein encoding Babesia divergens Erythrocyte Binding Protein (BdEBP) was produced in Escherichia coli in the current study, and its antiserum was prepared in mice for further molecular characterization. Western blotting and indirect fluorescent antibody test (IFAT) revealed the specific reaction of the anti-rBdEBP serum with a corresponding authentic protein of B...
July 22, 2017: Parasitology International
https://www.readbyqxmd.com/read/28734166/naturally-occurring-immunomodulators-with-antitumor-activity-an-insight-on-their-mechanisms-of-action
#7
REVIEW
Shimaa Ibrahim Abdelmonym Mohamed, Ibrahim Jantan, Md Areeful Haque
Natural products with immunomodulatory activity are widely used in treatment of many diseases including autoimmune diseases, inflammatory disorders in addition to cancer. They gained a great interest in the last decades as therapeutic agents since they provide inexpensive and less toxic products than the synthetic chemotherapeutic agents. Immunomodulators are the agents that have the ability to boost or suppress the host defense response that can be used as a prophylaxis as well as in combination with other therapeutic modalities...
July 19, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28733879/anticancer-activity-of-salicin-and-fenofibrate
#8
Marwa Sabaa, Hassan M ELFayoumi, Shimaa Elshazly, Mahmoud Youns, Waleed Barakat
Cancer refers to a disorder of cell proliferation that leads to tumor production. Cancer is usually treated by surgery, chemotherapeutic drugs, and radiation. Despite the presence of many anticancer drugs, cancer is still an uncontrolled disease and is a major cause of death worldwide. In addition, most anticancer drugs have severe side effects that can limit their use in some patients. This study aims to investigate the possible anticancer activity of two clinically used drugs: a natural antioxidant agent (salicin) and an antihyperlipidemic agent (fenofibrate) against two breast cancer models (in vivo EAC and in vitro MCF7) and the pancreatic cancer cell line (Panc-1)...
July 21, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28707636/implementation-and-evaluation-of-a-patient-safety-course-in-a-problem-based-learning-program
#9
Sarah Ahmed Eltony, Nahla Hassan El-Sayed, Shimaa El-Sayed El-Araby, Salah Eldin Kassab
BACKGROUND: Since the development of the WHO patient safety curriculum guide, there has been insufficient reporting regarding the implementation and evaluation of patient safety courses in undergraduate problem-based learning (PBL) programs. This study is designed to implement a patient safety course to undergraduate students in a PBL medical school and evaluate this course by examining its effects on students' knowledge and satisfaction. METHODS: The target population included year 6 medical students (n = 71) at the Faculty of Medicine, Suez Canal University in Egypt...
January 2017: Education for Health: Change in Training & Practice
https://www.readbyqxmd.com/read/28679108/withdrawn-conversion-of-food-processing-wastes-to-biofuel-using-clostridia
#10
Mohamed Hemida Abd-Alla, Abdel-Naser Ahmed Zohri, Abdel-Wahab Elsadek El-Enany, Shimaa Mohamed Ali
This article has been withdrawn: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been withdrawn at the request of the editor and publisher. The publisher regrets that an error occurred which led to the premature publication of this paper. This error bears no reflection on the article or its authors. The publisher apologizes to the authors and the readers for this unfortunate error.
July 2, 2017: Anaerobe
https://www.readbyqxmd.com/read/28655583/evaluation-of-the-inhibitory-effect-of-n-acetyl-l-cysteine-on-babesia-and-theileria-parasites
#11
Mohamed Abdo Rizk, Shimaa Abd El-Salam El-Sayed, Mahmoud AbouLaila, Naoaki Yokoyama, Ikuo Igarashi
N-acetyl-L-cysteine is known to have antibacterial, antiviral, antimalarial, and antioxidant activities. Therefore, the in vitro inhibitory effect of this hit was evaluated in the present study on the growth of Babesia and Theileria parasites. The in vitro growth of Babesia bovis, Babesia bigemina, Babesia divergens, Theileria equi, and Babesia caballi that were tested was significantly inhibited (P < 0.05) by micromolar concentrations of N-acetyl-L-cysteine. The inhibitory effect of N-acetyl-L-cysteine was synergistically potentiated when used in combination with diminazene aceturate on B...
August 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28651490/antiangiogenic-activity-of-vitexicarpine-in-experimentally-induced-hepatocellular-carcinoma-impact-on-vascular-endothelial-growth-factor-pathway
#12
Shimaa M Hassoun, Noha Abdel-Rahman, Entsar I Eladl, Mamdouh M El-Shishtawy
Angiogenesis plays important roles in progression of hepatocellular carcinoma. The antiangiogenic mechanisms of vitexicarpine are not fully defined. Therefore, we conducted the following study to evaluate the antiangiogenic mechanism and antitumor activity of vitexicarpine in vivo model of hepatocellular carcinoma through modulation of vascular endothelial growth factor signaling pathway. Hepatocellular carcinoma was induced in Sprague Dawley rats by thioacetamide. Hepatocellular carcinoma was assessed by measuring serum alpha-fetoprotein and investigating liver sections stained with hematoxylin/eosin...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28585911/transplant-of-hepatocytes-undifferentiated-mesenchymal-stem-cells-and-in-vitro-hepatocyte-differentiated-mesenchymal-stem-cells-in-a-chronic-liver-failure-experimental-model-a-comparative-study
#13
Hanan El Baz, Zeinab Demerdash, Manal Kamel, Shimaa Atta, Faten Salah, Salwa Hassan, Olfat Hammam, Heba Khalil, Safa Meshaal, Inas Raafat
OBJECTIVES: Liver transplant is the cornerstone line of treatment for chronic liver diseases; however, the long list of complications and obstacles stand against this operation. Searching for new modalities for treatment of chronic liver illness is a must. In the present research, we aimed to compare the effects of transplant of undifferentiated human mesenchymal stem cells, in vitro differentiated mesenchymal stem cells, and adult hepatocytes in an experimental model of chronic liver failure...
June 5, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28525356/synthesis-biological-activity-and-molecular-modeling-study-of-new-schiff-bases-incorporated-with-indole-moiety
#14
Ahmed H Halawa, Shimaa Mohamed Abd El-Gilil, Ahmed H Bedair, Mohamed Shaaban, Marcel Frese, Norbert Sewald, Essam M Eliwa, Ahmed M El-Agrody
A new series of heterocyclic Schiff bases 2-9 containing indole moiety were synthesized by facile and efficient condensation of indole-3/2/5-carboxaldehyde (1a/1b/1c) with different aromatic and heterocyclic primary amines using conventional and/or microwave irradiation methods. The structures of the obtained compounds were assigned by sophisticated spectroscopic and spectrometric techniques (1D-NMR, 2D-NMR and MS). The synthesized compounds were screened for their cytotoxicity and antibacterial activities...
May 18, 2017: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/28489028/synthesis-and-characterization-of-nano-conducting-copolymer-composites-efficient-sorbents-for-organic-pollutants
#15
Khadija M Emran, Shimaa M Ali, Aishah L L Al-Oufi
Nano-conducting copolymers of aniline (ANI) and pyrrole (Py) with silica of different starting monomer ratios are prepared by oxidative chemical polymerization. X-ray diffraction (XRD) data showed that polyaniline (PANI) is the predominant phase in copolymer composites with a higher starting ANI monomer ratio while polypyrrole (PPy) is the major phase for other prepared samples. Transmission and scanning electron microscope images ascertained XRD results where hexagonal-shaped particles are assigned to PANI/SiO₂ and poly(9ANI-co-1Py)/SiO₂ samples; the cauliflower morphology can be observed for PPy/SiO₂, poly(1ANI-co-9Py)/SiO₂, poly(1ANI-co-2Py)/SiO₂, and poly(1ANI-co-1Py)/SiO₂ samples...
May 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28480960/itpa-gene-polymorphism-94c-a-effects-on-ribavirin-induced-anemia-during-therapy-in-egyptian-patients-with-chronic-hepatitis-c
#16
Maissa El Raziky, Naglaa A Zayed, Amin Abdel Baki, Shimaa A Mansour, Rasha M H Shahin
Inosine triphosphatase (ITPA) gene variants can protect against ribavirin (RBV)-induced anemia in patients treated for chronic hepatitis C. The aim of this study was to determine the relationship between genetic variants of ITPA polymorphism, anemia, RBV dose reduction, and treatment response in hepatitis C virus (HCV)-infected patients. This study was conducted on 97 Egyptian chronic HCV patients who were scheduled for pegylated-interferon (PEG-INF) /RBV therapy. ITPA genotypes rs1127354 were determined by Real Time PCR melting curve analysis...
May 8, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28480401/prospective-effect-of-red-algae-actinotrichia-fragilis-against-some-osteoarthritis-aetiology
#17
Amany A Sayed, Shimaa A Sadek, Amel M Solimán, Mohamed Marzouk
BACKGROUND: Osteoarthritis (OA) is a progressive disease characterized by joints pain and articular cartilage destruction. Most of the current treatment strategies for OA are effective for symptoms relief but are accompanied with adverse side effect. Thus, the present investigation aims to evaluate the potential influence of red algae, Actinotrichia fragilis, in the dry powder form (AFP) or gel form (AFG) on some relevant factors of OA progression as well as assess its safety through in vitro and in vivo experiments...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28432344/aptamer-based-label-free-electrochemical-biosensor-array-for-the-detection-of-total-and-glycated-hemoglobin-in-human-whole-blood
#18
Shimaa Eissa, Mohammed Zourob
The increase of the level of glucose in blood leads to an increase in the fraction of glycated hemoglobin (HbA1c). Therefore, the percentage of HbA1c in the blood can serve as a marker for the average glucose level over the past three months and thus, it can be used to diagnose diabetes. Here, we report the selection, identification and characterization of specific DNA aptamers against HbA1c- and total hemoglobin (tHb) and their integration into an electrochemical array sensing platform. High affinity and specificity aptamers were selected in vitro showing dissociation constants of 2...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28347210/poly-glycerol-methacrylate-based-degradable-nanoparticles-for-delivery-of-small-interfering-rna
#19
Noha G Morsi, Shimaa M Ali, Sherouk S Elsonbaty, Ahmed A Afifi, Mostafa A Hamad, Hui Gao, Mahmoud Elsabahy
Nucleic acids therapeutic efficiency is generally limited by their low stability and intracellular bioavailability, and by the toxicity of the carriers used to deliver them to the target sites. Aminated poly(glycerol methacrylate) polymers are biodegradable and pH-sensitive polymers that have been used previously to deliver antisense oligonucleotide and showed high transfection efficiency. The purpose of this study is to compare the efficiency and toxicity of aminated linear poly(glycerol methacrylate) (ALT) biodegradable polymer to the most commonly used cationic degradable (i...
March 27, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28320588/herpes-zoster-reactivation-in-patients-with-chronic-hepatitis-c-under-treatment-with-directly-acting-antiviral-agents-a-case-series
#20
Mohamed El Kassas, Mohamed Naguib Wifi, Reem Mahdy, Shimaa Afify, Enas Hafez, Yasmeen Abd El Latif, Marwa Ezzat, Adel El Tahan, Naglaa Youssef, Gamal Esmat
We report a series of cutaneous Herpes Zoster (HZ) reactivation cases in patients with hepatitis C virus (HCV) infection treated with directly acting antiviral (DAA) agents. Five cases were detected among 2133 treated patients with DAAs at one of the specialized viral hepatitis treatment centers in Egypt. A control group including 2300 age and sex matched HCV patients who were previously treated with pegylated interferon and ribavirin did not show any HZ reactivation reports while on treatment. None of cases had an evidence of immunosuppression or a risk factor for HZ reactivation...
March 2017: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
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