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https://www.readbyqxmd.com/read/28912324/permanent-draft-genome-sequence-of-photorhabdus-temperata-strain-hm-an-entomopathogenic-bacterium-isolated-from-nematodes
#1
Shimaa Ghazal, Erik Swanson, Stephen Simpson, Krystalynne Morris, Feseha Abebe-Akele, W Kelley Thomas, Kamal M Khalil, Louis S Tisa
Photorhabdus temperata strain Hm is an entomopathogenic bacterium that forms a symbiotic association with Heterorhabditis nematodes. Here, we report a 5.0-Mbp draft genome sequence for P. temperata strain Hm with a G+C content of 44.1% and containing 4,226 candidate protein-encoding genes.
September 14, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28888656/molecular-characterization-of-circulating-foot-and-mouth-disease-virus-fmdv-serotype-o-topotype-ea-3-and-serotype-a-african-topotype-genotype-iv-in-egypt-2016
#2
Mohamed A Soltan, Ali H Negmaldin, Mohamed M El-Diasty, Shimaa M G Mansour, Maha A Elbadry, Rebecca P Wilkes
In January-April 2016, cattle and buffalo farm owners and veterinarians reported clinical signs suggestive of foot and mouth disease virus (FMDV) outbreaks among non-vaccinated cattle and buffalo herds in Egypt. The clinical disease observed was either mild (small oral lesions and speedy recovery) or severe (extensive oral lesions and/or mortalities), and the form of the disease (either mild or severe) segregated by farm. This study aimed to confirm the presence of FMDV and to characterize the circulating strains associated with the outbreaks...
September 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28841783/zinc-oxide-nanoparticle-toxicity-in-embryonic-zebrafish-mitigation-with-different-natural-organic-matter
#3
Shimaa M Kteeba, Hala I El-Adawi, Osman A El-Rayis, Ahmed E El-Ghobashy, Jessica L Schuld, Kurt R Svoboda, Laodong Guo
Exposure experiments were conducted to evaluate the influence of dissolved organic matter (DOM) on the toxicity of ZnO-NPs (10-30 nm) and dissolved Zn at sub-lethal doses (50 and 5 ppm, respectively) to zebrafish (Danio rerio). Humic acid, alginic acid, bovine serum albumin and various natural DOM isolated from rivers as the Milwaukee River-WI (NOMW), Yukon River-AK (NOMA) and Suwannee River-GA DOM (NOMS) were used to represent humic substances (HA), carbohydrates (CHO), proteins (PTN), and natural organic matter (NOM), respectively...
November 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28836639/titanium-nanoparticles-tio2-graphene-oxide-nanosheets-go
#4
Mona A Mohamed, Shimaa A Atty, Hanan A Merey, Taghreed A Fattah, Christopher W Foster, Craig E Banks
An effective electrochemical sensing platform for the simultaneous determination of benzocaine (BEN) and antipyrine (ANT) based upon titanium dioxide nanoparticle (TiO2)/graphene oxide nanosheet (GO) bulk modified carbon paste electrodes (TiO2-GO/CPE) is reported. The TiO2-GO/CPE electrochemical sensing platform is found to exhibit linear ranges from 1.0 × 10(-6) to 1.0 × 10(-4) M and 1.2 × 10(-8) to 8.0 × 10(-5) M for BEN and ANT, respectively. The TiO2-GO/CPE sensor is explored towards the analysis of BEN and ANT in oral fluid (saliva) and pharmaceutical products...
August 24, 2017: Analyst
https://www.readbyqxmd.com/read/28832071/prognostic-value-of-twist-1-e-cadherin-and-ezh2-in-prostate-cancer-an-immunohistochemical-study
#5
Aziza E Abdelrahman, Shimaa A Arafa, Ragab A Ahmed
OBJECTIVE: There is an urgent need to identify molecular biomarkers rather than clinical markers to distinguish aggressive prostate cancer from the indolent majority for proper treatment and accurate prediction of prognosis. We aimed to investigate the immunohistochemical expression of epithelial-mesenchymal transition (EMT)-related molecules (Twist-1 and E-cadherin) and the stem cell marker EZH2 in prostate cancer and to assess their ability to identify the high-risk patients, in a trial to explore their prognostic implications...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28831754/comparative-therapeutic-effect-of-steroidal-and-non-steroidal-anti-inflammatory-drugs-on-pro-inflammatory-cytokine-production-in-water-buffalo-calves-bubalus-bubalis-naturally-infected-with-bronchopneumonia-a-randomized-clinical-trial
#6
Mohamed Abdo Rizk, Motamed Elsayed Mahmoud, Shimaa Abd El-Salam El-Sayed, Doaa Salman
In the current study, we compared the therapeutic effects of a non-steroidal and a steroidal anti-inflammatory drug on the production of pro-inflammatory cytokines, interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-12p40 (IL-12p40), interferon gamma (IFNγ), and tumor necrosis factor alpha (TNF-α) in the blood of water buffalo (Bubalus bubalis) calves naturally infected by bronchopneumonia. Twenty-seven buffalo calves (7 ± 2-month-old, 163 ± 12 kg) reared in smallholder farms in El-Dakahlia province in Egypt were identified to have bronchopneumonia and randomly allocated into three equal groups...
August 22, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28831220/serotyping-antibiotic-susceptibility-and-virulence-genes-screening-of-escherichia-coli-isolates-obtained-from-diarrheic-buffalo-calves-in-egyptian-farms
#7
Ashraf S Hakim, Shimaa T Omara, Sohier M Syame, Ehab A Fouad
AIM: In Egypt as in many other countries, river water buffalo (Bubalus bubalis) is considered an important source of high-quality milk and meat supply. The objective of this study was to investigate serotypes, virulence genes, and antibiotic resistance determinants profiles of Escherichia coli isolated from buffalo at some places in Egypt; noticibly, this issue was not discussed in the country yet. MATERIALS AND METHODS: A number of 58 rectal samples were collected from diarrheic buffalo calves in different regions in Egypt, and bacteriological investigated for E...
July 2017: Veterinary World
https://www.readbyqxmd.com/read/28808805/molecular-factors-regulating-e-cadherin-expression-in-urothelial-bladder-cancer-and-their-correlations-with-the-clinicopathological-features
#8
Samia Hussein, Hala Mosaad, Hayam E Rashed, Shimaa Ahmed, Ahmed Ragab, Eman I Ismail
This study aimed to assess the expression of S100A4, Twist and E-cadherin (mRNA and protein) in urothelial bladder cancer, investigate the correlation between them and evaluate their association with the clinicopathological features of the disease. The study included 54 patients diagnosed as urothelial bladder cancer of different stages and grades. The expression levels of S100A4, Twist and E-cadherin (mRNA and protein) in tissue samples were determined by quantitative RT-PCR and immunohistochemistry. The expression of S100A4 and Twist was significantly upregulated while E- cadherin was significantly downregulated in urothelial bladder cancer tissues compared to the adjacent surrounding normal bladder tissues at both mRNA and protein levels (p < 0...
August 14, 2017: Molecular Biology Reports
https://www.readbyqxmd.com/read/28795806/converting-teixobactin-into-a-cationic-antimicrobial-peptide-amp
#9
Shimaa A H Abdel Monaim, Estelle J Ramchuran, Ayman El-Faham, Fernando Albericio, Beatriz G de la Torre
Teixobactin is a head to side chain cyclodepsipeptide that contains two positive charges. One is found in the cycle, as a result of the presence of the guanidino-unusual amino acid L-allo-End, while the other is at the N-terminal. Here we introduce 26 new Teixobactin analogues with an increasing number of positive charges. In an attempt to fine-tune the biological activity of Teixobactin, we examined the effect of cationicity on the SAR of these analogues. The maximum number of positive charges to maintain the activity are three to four...
August 23, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28764171/evaluation-of-hypoxia-inducible-factor-1%C3%AE-and-glucose-transporter-1-expression-in-non-melanoma-skin-cancer-an-immunohistochemical-study
#10
Iman Seleit, Ola Ahmed Bakry, Dalia Rifaat Al-Sharaky, Rania Abdel Aziz Ragab, Shimaa Ahmed Al-Shiemy
INTRODUCTION: Hypoxia Inducible Factor-1 (HIF-1) is a mediator enabling cell adaptation to hypoxia. It plays its role mainly through transcription of many target genes including Glucose Transporter-1 (GLUT-1) gene. AIM: The present work aimed at evaluating the pattern and distribution of HIF-1α and GLUT-1 in each case and control. MATERIALS AND METHODS: A case-control and retrospective study was conducted on archival blocks diagnosed from pathology department as, Basal Cell Carcinoma (BCC, 20 cases), cutaneous Squamous Cell Carcinoma (SCC, 20 cases) and 20 normal site-matched skin biopsies from age and gender-matched healthy subjects as a control...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28763751/berberine-ameliorates-methotrexate-induced-liver-injury-by-activating-nrf2-ho-1-pathway-and-ppar%C3%AE-and-suppressing-oxidative-stress-and-apoptosis-in-rats
#11
Ayman M Mahmoud, Walaa G Hozayen, Shimaa M Ramadan
Berberine (BBR) is a natural isoquinoline alkaloid with very impressive health benefits. It is one of the most effective natural supplements available; however, its ameliorative mechanism against methotrexate (MTX)-induced liver injury is not well defined. This study investigated the protective effect of BBR against MTX hepatotoxicity, focusing on its ability to attenuate oxidative stress and apoptosis and to activate nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling and peroxisome proliferator activated receptor gamma (PPARγ)...
July 29, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28758172/erratum-to-screening-of-blood-levels-of-mercury-cadmium-and-copper-in-pregnant-women-in-dakahlia-egypt-new-attention-to-an-old-problem
#12
Shimaa M Motawei, Hossam E Gouda
No abstract text is available yet for this article.
July 31, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28752960/after-successful-hepatitis-c-virus-antiviral-therapy-it-looks-that-normal-alanine-aminotransferase-level-is-not-the-normal
#13
Mohamed El Kassas, Mohamed Alboraie, Aya Mostafa, Reem Ezzat, Adel El Tahan, Shimaa Afify, Ahmed Sweedy, Ibrahim Kabbash, Gamal Esmat
BACKGROUND: Normal serum alanine aminotransferase (ALT) levels differ with age, gender, and body mass index. Adjusting the upper limits of normal (ULN) for ALT needs further research in different populations. Aim of this work was to monitor the effect of successful chronic hepatitis C (CHC) treatment on the ALT levels in patients with normal pretreatment ALT. METHODS: Data of 1160 CHC patients with persistent pretreatment normal liver enzymes were retrospectively analyzed...
July 28, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28743470/molecular-identification-and-antigenic-characterization-of-babesia-divergens-erythrocyte-binding-protein-bdebp-as-a-potential-vaccine-candidate
#14
Shimaa Abd El-Salam El-Sayed, Mohamed Abdo Rizk, Mohamad Alaa Terkawi, Naoaki Yokoyama, Ikuo Igarashi
Host cell invasion is the only step where Babesia parasites are extracellular, and their survival is menaced during this step. Therefore, interfering with this critical stage is a target for an anti-Babesia intervention strategy. In this regard, recombinant protein encoding Babesia divergens Erythrocyte Binding Protein (BdEBP) was produced in Escherichia coli in the current study, and its antiserum was prepared in mice for further molecular characterization. Western blotting and indirect fluorescent antibody test (IFAT) revealed the specific reaction of the anti-rBdEBP serum with a corresponding authentic protein of B...
July 22, 2017: Parasitology International
https://www.readbyqxmd.com/read/28734166/naturally-occurring-immunomodulators-with-antitumor-activity-an-insight-on-their-mechanisms-of-action
#15
REVIEW
Shimaa Ibrahim Abdelmonym Mohamed, Ibrahim Jantan, Md Areeful Haque
Natural products with immunomodulatory activity are widely used in treatment of many diseases including autoimmune diseases, inflammatory disorders in addition to cancer. They gained a great interest in the last decades as therapeutic agents since they provide inexpensive and less toxic products than the synthetic chemotherapeutic agents. Immunomodulators are the agents that have the ability to boost or suppress the host defense response that can be used as a prophylaxis as well as in combination with other therapeutic modalities...
July 19, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28733879/anticancer-activity-of-salicin-and-fenofibrate
#16
Marwa Sabaa, Hassan M ELFayoumi, Shimaa Elshazly, Mahmoud Youns, Waleed Barakat
Cancer refers to a disorder of cell proliferation that leads to tumor production. Cancer is usually treated by surgery, chemotherapeutic drugs, and radiation. Despite the presence of many anticancer drugs, cancer is still an uncontrolled disease and is a major cause of death worldwide. In addition, most anticancer drugs have severe side effects that can limit their use in some patients. This study aims to investigate the possible anticancer activity of two clinically used drugs: a natural antioxidant agent (salicin) and an antihyperlipidemic agent (fenofibrate) against two breast cancer models (in vivo EAC and in vitro MCF7) and the pancreatic cancer cell line (Panc-1)...
July 21, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28707636/implementation-and-evaluation-of-a-patient-safety-course-in-a-problem-based-learning-program
#17
Sarah Ahmed Eltony, Nahla Hassan El-Sayed, Shimaa El-Sayed El-Araby, Salah Eldin Kassab
BACKGROUND: Since the development of the WHO patient safety curriculum guide, there has been insufficient reporting regarding the implementation and evaluation of patient safety courses in undergraduate problem-based learning (PBL) programs. This study is designed to implement a patient safety course to undergraduate students in a PBL medical school and evaluate this course by examining its effects on students' knowledge and satisfaction. METHODS: The target population included year 6 medical students (n = 71) at the Faculty of Medicine, Suez Canal University in Egypt...
January 2017: Education for Health: Change in Training & Practice
https://www.readbyqxmd.com/read/28679108/withdrawn-conversion-of-food-processing-wastes-to-biofuel-using-clostridia
#18
Mohamed Hemida Abd-Alla, Abdel-Naser Ahmed Zohri, Abdel-Wahab Elsadek El-Enany, Shimaa Mohamed Ali
This article has been withdrawn: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been withdrawn at the request of the editor and publisher. The publisher regrets that an error occurred which led to the premature publication of this paper. This error bears no reflection on the article or its authors. The publisher apologizes to the authors and the readers for this unfortunate error.
July 2, 2017: Anaerobe
https://www.readbyqxmd.com/read/28655583/evaluation-of-the-inhibitory-effect-of-n-acetyl-l-cysteine-on-babesia-and-theileria-parasites
#19
Mohamed Abdo Rizk, Shimaa Abd El-Salam El-Sayed, Mahmoud AbouLaila, Naoaki Yokoyama, Ikuo Igarashi
N-acetyl-L-cysteine is known to have antibacterial, antiviral, antimalarial, and antioxidant activities. Therefore, the in vitro inhibitory effect of this hit was evaluated in the present study on the growth of Babesia and Theileria parasites. The in vitro growth of Babesia bovis, Babesia bigemina, Babesia divergens, Theileria equi, and Babesia caballi that were tested was significantly inhibited (P < 0.05) by micromolar concentrations of N-acetyl-L-cysteine. The inhibitory effect of N-acetyl-L-cysteine was synergistically potentiated when used in combination with diminazene aceturate on B...
August 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28651490/antiangiogenic-activity-of-vitexicarpine-in-experimentally-induced-hepatocellular-carcinoma-impact-on-vascular-endothelial-growth-factor-pathway
#20
Shimaa M Hassoun, Noha Abdel-Rahman, Entsar I Eladl, Mamdouh M El-Shishtawy
Angiogenesis plays important roles in progression of hepatocellular carcinoma. The antiangiogenic mechanisms of vitexicarpine are not fully defined. Therefore, we conducted the following study to evaluate the antiangiogenic mechanism and antitumor activity of vitexicarpine in vivo model of hepatocellular carcinoma through modulation of vascular endothelial growth factor signaling pathway. Hepatocellular carcinoma was induced in Sprague Dawley rats by thioacetamide. Hepatocellular carcinoma was assessed by measuring serum alpha-fetoprotein and investigating liver sections stained with hematoxylin/eosin...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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