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https://www.readbyqxmd.com/read/28585911/transplant-of-hepatocytes-undifferentiated-mesenchymal-stem-cells-and-in-vitro-hepatocyte-differentiated-mesenchymal-stem-cells-in-a-chronic-liver-failure-experimental-model-a-comparative-study
#1
Hanan El Baz, Zeinab Demerdash, Manal Kamel, Shimaa Atta, Faten Salah, Salwa Hassan, Olfat Hammam, Heba Khalil, Safa Meshaal, Inas Raafat
OBJECTIVES: Liver transplant is the cornerstone line of treatment for chronic liver diseases; however, the long list of complications and obstacles stand against this operation. Searching for new modalities for treatment of chronic liver illness is a must. In the present research, we aimed to compare the effects of transplant of undifferentiated human mesenchymal stem cells, in vitro differentiated mesenchymal stem cells, and adult hepatocytes in an experimental model of chronic liver failure...
June 5, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28525356/synthesis-biological-activity-and-molecular-modeling-study-of-new-schiff-bases-incorporated-with-indole-moiety
#2
Ahmed H Halawa, Shimaa Mohamed Abd El-Gilil, Ahmed H Bedair, Mohamed Shaaban, Marcel Frese, Norbert Sewald, Essam M Eliwa, Ahmed M El-Agrody
A new series of heterocyclic Schiff bases 2-9 containing indole moiety were synthesized by facile and efficient condensation of indole-3/2/5-carboxaldehyde (1a/1b/1c) with different aromatic and heterocyclic primary amines using conventional and/or microwave irradiation methods. The structures of the obtained compounds were assigned by sophisticated spectroscopic and spectrometric techniques (1D-NMR, 2D-NMR and MS). The synthesized compounds were screened for their cytotoxicity and antibacterial activities...
May 18, 2017: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/28489028/synthesis-and-characterization-of-nano-conducting-copolymer-composites-efficient-sorbents-for-organic-pollutants
#3
Khadija M Emran, Shimaa M Ali, Aishah L L Al-Oufi
Nano-conducting copolymers of aniline (ANI) and pyrrole (Py) with silica of different starting monomer ratios are prepared by oxidative chemical polymerization. X-ray diffraction (XRD) data showed that polyaniline (PANI) is the predominant phase in copolymer composites with a higher starting ANI monomer ratio while polypyrrole (PPy) is the major phase for other prepared samples. Transmission and scanning electron microscope images ascertained XRD results where hexagonal-shaped particles are assigned to PANI/SiO₂ and poly(9ANI-co-1Py)/SiO₂ samples; the cauliflower morphology can be observed for PPy/SiO₂, poly(1ANI-co-9Py)/SiO₂, poly(1ANI-co-2Py)/SiO₂, and poly(1ANI-co-1Py)/SiO₂ samples...
May 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28480960/itpa-gene-polymorphism-94c-a-effects-on-ribavirin-induced-anemia-during-therapy-in-egyptian-patients-with-chronic-hepatitis-c
#4
Maissa El Raziky, Naglaa Ali Zayed, Amin Abdel Baki, Shimaa Afify Mansour, Rasha Mohamad Hosny Shahin
PROBLEM: Inosine triphosphatase (ITPA) gene variants can protect against ribavirin (RBV)-induced anemia in patients treated for chronic hepatitis C. The aim of this study was to determine the relationship between genetic variants of ITPA polymorphism, anemia, RBV dose reduction and treatment response in hepatitis C virus (HCV)-infected patients. METHOD OF STUDY: This study was conducted on 97 Egyptian chronic HCV patients who were scheduled for pegylated-interferon (PEG-INF) /RBV therapy...
May 8, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28480401/prospective-effect-of-red-algae-actinotrichia-fragilis-against-some-osteoarthritis-aetiology
#5
Amany A Sayed, Shimaa A Sadek, Amel M Solimán, Mohamed Marzouk
BACKGROUND: Osteoarthritis (OA) is a progressive disease characterized by joints pain and articular cartilage destruction. Most of the current treatment strategies for OA are effective for symptoms relief but are accompanied with adverse side effect. Thus, the present investigation aims to evaluate the potential influence of red algae, Actinotrichia fragilis, in the dry powder form (AFP) or gel form (AFG) on some relevant factors of OA progression as well as assess its safety through in vitro and in vivo experiments...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28432344/aptamer-based-label-free-electrochemical-biosensor-array-for-the-detection-of-total-and-glycated-hemoglobin-in-human-whole-blood
#6
Shimaa Eissa, Mohammed Zourob
The increase of the level of glucose in blood leads to an increase in the fraction of glycated hemoglobin (HbA1c). Therefore, the percentage of HbA1c in the blood can serve as a marker for the average glucose level over the past three months and thus, it can be used to diagnose diabetes. Here, we report the selection, identification and characterization of specific DNA aptamers against HbA1c- and total hemoglobin (tHb) and their integration into an electrochemical array sensing platform. High affinity and specificity aptamers were selected in vitro showing dissociation constants of 2...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28347210/poly-glycerol-methacrylate-based-degradable-nanoparticles-for-delivery-of-small-interfering-rna
#7
Noha G Morsi, Shimaa M Ali, Sherouk S Elsonbaty, Ahmed A Afifi, Mostafa A Hamad, Hui Gao, Mahmoud Elsabahy
Nucleic acids therapeutic efficiency is generally limited by their low stability and intracellular bioavailability, and by the toxicity of the carriers used to deliver them to the target sites. Aminated poly(glycerol methacrylate) polymers are biodegradable and pH-sensitive polymers that have been used previously to deliver antisense oligonucleotide and showed high transfection efficiency. The purpose of this study is to compare the efficiency and toxicity of aminated linear poly(glycerol methacrylate) (ALT) biodegradable polymer to the most commonly used cationic degradable (i...
March 27, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28320588/herpes-zoster-reactivation-in-patients-with-chronic-hepatitis-c-under-treatment-with-directly-acting-antiviral-agents-a-case-series
#8
Mohamed El Kassas, Mohamed Naguib Wifi, Reem Mahdy, Shimaa Afify, Enas Hafez, Yasmeen Abd El Latif, Marwa Ezzat, Adel El Tahan, Naglaa Youssef, Gamal Esmat
We report a series of cutaneous Herpes Zoster (HZ) reactivation cases in patients with hepatitis C virus (HCV) infection treated with directly acting antiviral (DAA) agents. Five cases were detected among 2133 treated patients with DAAs at one of the specialized viral hepatitis treatment centers in Egypt. A control group including 2300 age and sex matched HCV patients who were previously treated with pegylated interferon and ribavirin did not show any HZ reactivation reports while on treatment. None of cases had an evidence of immunosuppression or a risk factor for HZ reactivation...
March 2017: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/28300588/immobilization-of-chitosan-nanolayers-on-the-surface-of-nano-titanium-oxide-as-a-novel-nanocomposite-for-efficient-removal-of-la-iii-from-water
#9
Mohamed E Mahmoud, Samir A A Abou Ali, Ahmed M G Nassar, Shimaa M T Elweshahy, Somia B Ahmed
A novel nanocomposite has been designed and synthesized via surface crosslinking of chitosan nanolayers (NChit) with titanium oxide nanoparticles (NTiO2) using glutaraldehyde (Glu) as the crosslinking agent. A simple and green surface chemical reaction was accomplished by the aid of microwave heating process to enforce surface encapsulation and functionalization for the production of the aimed NTiO2-Glu-NChit nanocomposite. The average particles size of nanocomposite was characterized in the range of 52-58nm using SEM and confirmed by the HR-TEM...
August 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28272687/prognostic-value-of-twist-1-e-cadherin-and-ezh2-in-prostate-cancer-an-immunohistochemical-study
#10
Aziza E Abdelrahman, Shimaa A Arafa, Ragab A Ahmed
OBJECTIVE: There is an urgent need to identify molecular biomarkers rather than clinical markers to distinguish aggressive prostate cancer from the indolent majority for proper treatment and accurate prediction of prognosis. We aimed to investigate the immunohistochemical expression of epithelial-mesenchymal transition (EMT)-related molecules (Twist-1 and E-cadherin) and the stem cell marker EZH2 in prostate cancer and to assess their ability to identify the high-risk patients, in a trial to explore their prognostic implications...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28264674/epstein-barr-virus-and-cytomegalovirus-infections-and-their-clinical-relevance-in-egyptian-leukemic-pediatric-patients
#11
Samah Aly Loutfy, Maha A Abo-Shadi, Mohamed Fawzy, Mohamed El-Wakil, Shimaa A Metwally, Manar M Moneer, Nasra F Abdel Fattah, Sara Kassem, Ahmed Elgebaly
BACKGROUND: Epstein-Barr virus (EBV) and human cytomegalovirus (CMV) infections are environmental risk factors affecting the outcome of cancer due to an impairment in the cell-mediated immunity. Therefore, this study aimed to detect the frequency of EBV and CMV DNA and their association with clinical characteristics and outcome of pediatric leukemic patients. METHODS: Samples of 50 immunocompromised pediatric leukemic patients and 30 apparently healthy children were subjected to the amplification of EBV DNA by one version of PCR targeting the Bam H1 W region of the genomic region of EBV, and the amplification of CMV DNA by targeting the CMV UL97 genomic region by a second round PCR...
March 6, 2017: Virology Journal
https://www.readbyqxmd.com/read/28264568/selection-and-characterization-of-dna-aptamers-for-electrochemical-biosensing-of-carbendazim
#12
Shimaa Eissa, Mohammed Zourob
This article reports a novel aptamer-based impedimetric detection of carbendazim, a commonly used benzimidazole fungicide in agriculture. High affinity and specificity DNA aptamers against carbendazim were successfully selected using systematic evolution of ligand by exponential enrichment (SELEX). The dissociation constants (Kds) of the selected DNA aptamers after 10 in vitro selection cycles were characterized using fluorescence-based assays showing values in the nanomolar range. The aptamer which showed the highest degree of affinity and conformation change was used to fabricate an electrochemical aptasensor via self-assembly of thiol-modified aptamer on gold electrodes...
March 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28249845/efficacy-of-prophylactic-dexmedetomidine-in-preventing-postoperative-junctional-ectopic-tachycardia-after-pediatric-cardiac-surgery
#13
Doaa Mohamed El Amrousy, Nagat S Elshmaa, Mohamed El-Kashlan, Samir Hassan, Mohamed Elsanosy, Nahed Hablas, Shimaa Elrifaey, Wael El-Feky
BACKGROUND: Postoperative junctional ectopic tachycardia is one of the most serious arrhythmias that occur after pediatric cardiac surgery, difficult to treat and better to be prevented. Our aim was to assess the efficacy of prophylactic dexmedetomidine in preventing junctional ectopic tachycardia after pediatric cardiac surgery. METHODS AND RESULTS: A prospective controlled study was carried out on 90 children who underwent elective cardiac surgery for congenital heart diseases...
March 1, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28237255/high-affinity-truncated-dna-aptamers-for-the-development-of-fluorescence-based-progesterone-biosensors
#14
Hani A Alhadrami, Raja Chinnappan, Shimaa Eissa, Anas Abdel Rahamn, Mohammed Zourob
Aptamers have shown a number of potential applications in sensing and therapeutic due to the high affinity and specificity towards their target molecules. Not all the nucleotides in the full length aptamers are involved in the binding with their targets. The non-binding domain of the aptamer may affect the binding affinity of the aptamer-target complex. Mapping the aptamer binding region could increase the affinity and the specificity. In this paper, we designed aptamer-based fluorescence sensors from a truncated progesterone (P4) aptamer...
May 15, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28213655/molecular-characterization-of-the-unique-mesostephanus-appendiculatus-trematoda-cyathocotylidae-by-small-ribosomal-rna-from-egypt
#15
Nasr M El-Bahy, Eman K Bazh, Shimaa S Sorour, Nagwa M Elhawary
M esostephanus appendiculatus (Family: Cyathocotylidae) is one of the unique trematodes that complete their cycles in human and animal intestines in many countries of the world. The main source of its transmission is eating raw or undercooked infected fish muscle. Earliest analyses of genes to different parasites supported the analysis of helminthes either biological or morphological. This paper detected M. appendiculatus sequence with GenBank accession number gb (KY026782). Comparison of M. appendiculatus with other helminthes using BioEdit 7 and MEGA7 program shows some similarity in different points along its sequence...
April 2017: Parasitology Research
https://www.readbyqxmd.com/read/28116911/co-circulation-of-paramyxo-and-influenza-viruses-in-pigeons-in-egypt
#16
Shimaa M G Mansour, Fakry F Mohamed, Amal A M Eid, Sunil K Mor, Sagar M Goyal
In recent years, avian influenza virus (AIV) and Newcastle disease virus (NDV) have caused large-scale outbreaks in many countries, including Egypt. The culling and vaccination strategies have failed to control both viruses in Egypt. In this study, we investigated the outbreaks of nervous manifestations and deaths in pigeons between 2013 and 2015. The H5N1 subtype of the highly pathogenic avian influenza virus and pigeon paramyxovirus-1, an antigenic variant of NDV, were found to be the cause; AIV and pigeon paramyxovirus-1 were isolated from 61...
March 28, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28006685/in-vitro-selection-of-dna-aptamers-targeting-%C3%AE-lactoglobulin-and-their-integration-in-graphene-based-biosensor-for-the-detection-of-milk-allergen
#17
Shimaa Eissa, Mohammed Zourob
Food allergy has increased rapidly in recent years affecting millions of people worldwide. With the increased consumption of packed food nowadays, a sensitive, accurate and rapid screening method for potential food allergens has become an urgent need in order to protect the sensitive consumers from life-threatening reactions. The current detection methods for food allergens are mostly based on immunoassays which are costly and times-consuming. In this work, we developed an aptamer/graphene-based electrochemical biosensor for on-step, sensitive and low cost detection of β-lactoglobulin (β-LG) milk protein, one of the most common food allergens specially in infants...
May 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27987899/synthesis-and-characterization-of-poly-carboxymethyl-cellulose-for-enhanced-la-iii-sorption
#18
Ahmad A Tolba, Said I Mohamady, Shimaa S Hussin, Takaya Akashi, Yuka Sakai, Ahmed A Galhoum, Eric Guibal
The grafting of amino and carboxylic acid groups on cellulose increased La(III) sorption efficiency of cellulose: maximum sorption capacity increased from 38mgLag(-1) for cellulose to 101 and 170mgLag(-1) for amino derivative (PAC) and amino-carboxylic derivative (PCMC). Langmuir equation successfully fits sorption isotherms while uptake kinetics are effectively modeled using the pseudo-first order rate equation (though resistance to intraparticle diffusion plays a significant role in the control of metal recovery)...
February 10, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27974891/impact-of-exposure-to-fenitrothion-on-vital-organs-in-rats
#19
Rasha Abdel-Ghany, Ebaa Mohammed, Shimaa Anis, Waleed Barakat
This study was designed to investigate the impact of oral administration of fenitrothion (10 mg/kg) on liver, kidney, brain, and lung function in rats. The effect was studied on days 7, 14, 21, 28, and 42. Our results have shown deterioration in liver function as evidenced by the elevation in serum ALT, AST, ALP, and bilirubin and reduction in albumin and hepatic glycogen. This was associated with a state of hyperglycemia and hyperlipidemia and increased prothrombin time, while hemoglobin content was reduced...
2016: Journal of Toxicology
https://www.readbyqxmd.com/read/27908539/design-synthesis-molecular-docking-anti-proteus-mirabilis-and-urease-inhibition-of-new-fluoroquinolone-carboxylic-acid-derivatives
#20
Mohammed A A Abdullah, Gamal El-Din A A Abuo-Rahma, El-Shimaa M N Abdelhafez, Heba A Hassan, Rehab M Abd El-Baky
New hydroxamic acid, hydrazide and amide derivatives of ciprofloxacin in addition to their analogues of levofloxacin were prepared and identified by different spectroscopic techniques. Some of the prepared compounds revealed good activity against the urease splitting bacteria, Proteus mirabilis. The urease inhibitory activity was investigated using indophenol method. Most of the tested compounds showed better activity than the reference acetohydroxamic acid (AHA). The ciprofloxacin hydrazide derivative 3a and levofloxacin hydroxamic acid 7 experienced the highest activity (IC50=1...
February 2017: Bioorganic Chemistry
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