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https://www.readbyqxmd.com/read/28634452/establishing-the-basis-for-mechanobiology-based-physical-therapy-protocols-to-potentiate-cellular-healing-and-tissue-regeneration
#1
REVIEW
Joanna L Ng, Mariana E Kersh, Sharon Kilbreath, M Knothe Tate
Life is mechanobiological: mechanical stimuli play a pivotal role in the formation of structurally and functionally appropriate body templates through mechanobiologically-driven cellular and tissue re/modeling. The body responds to mechanical stimuli engendered through physical movement in an integrated fashion, internalizing and transferring forces from organ, through tissue and cellular length scales. In the context of rehabilitation and therapeutic outcomes, such mechanical stimuli are referred to as mechanotherapy...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28633152/state-of-pelvic-and-acetabular-surgery-in-the-developing-world-a-global-survey-of-orthopaedic-surgeons-at-surgical-implant-generation-network-sign-hospitals
#2
Paul S Whiting, Duane R Anderson, Daniel D Galat, Lewis G Zirkle, Douglas W Lundy, Hassan R Mir
OBJECTIVES: To document the current state of pelvic and acetabular surgery in the developing world and to identify critical areas for improvement in the treatment of these complex injuries. DESIGN: A 50-question online survey. SETTING: International, multicenter. PATIENTS/PARTICIPANTS: One hundred eighty-one orthopaedic surgeons at Surgical Implant Generation Network (SIGN) hospitals, which represent a cross-section of institutions in low- and middle-income countries that treat high-energy musculoskeletal trauma...
July 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28630733/return-to-running-after-arthroscopic-hip-surgery-literature-review-and-proposal-of-a-physical-therapy-protocol
#3
REVIEW
Matthew J Kraeutler, Joy Anderson, Jorge Chahla, Justin J Mitchell, Robyn Thompson-Etzel, Omer Mei-Dan, Cecilia Pascual-Garrido
The number of hip arthroscopy procedures has significantly increased in the last several years, thereby necessitating individualized rehabilitation protocols for patients following hip arthroscopy. The purpose of this article is to review the literature on rehabilitation protocols for patients following hip arthroscopy and to describe a new protocol specifically designed for patients to return to running following hip arthroscopy. A search of PubMed was performed through October 2016 to locate studies of rehabilitation protocols for patients wishing to return to sport/general activity following hip arthroscopy...
July 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/28630035/the-effects-of-preoperative-volume-replacement-in-diabetic-patients-undergoing-coronary-artery-bypass-grafting-surgery-protocol-for-a-randomized-controlled-trial-verdict-trial
#4
Madeleine Clout, Tracy Harris, Chris Rogers, Lucy Culliford, Jodi Taylor, Gianni Angelini, Pradeep Narayan, Barnaby Reeves, James Hillier, Kate Ashton, Kunal Sarkar, Raimondo Ascione
BACKGROUND: Diabetes mellitus is a major risk factor for prolonged hospital stays, renal failure, and mortality in patients having coronary artery bypass grafting (CABG). Complications pose a serious threat to patients and prolong intensive care and hospital stays. Low glomerular filtration rate (GFR) due to existing renal impairment or volume depletion may exacerbate acute renal impairment/failure in these patients. Preoperative volume replacement therapy (VRT) is reported to increase the GFR and we hypothesize that VRT will reduce renal impairment and related complications in diabetic patients...
June 19, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28620603/advances-in-the-knowledge-about-kidney-decellularization-and-repopulation
#5
REVIEW
Afrânio Côgo Destefani, Gabriela Modenesi Sirtoli, Breno Valentim Nogueira
End-stage renal disease (ESRD) is characterized by the progressive deterioration of renal function that may compromise different tissues and organs. The major treatment indicated for patients with ESRD is kidney transplantation. However, the shortage of available organs, as well as the high rate of organ rejection, supports the need for new therapies. Thus, the implementation of tissue bioengineering to organ regeneration has emerged as an alternative to traditional organ transplantation. Decellularization of organs with chemical, physical, and/or biological agents generates natural scaffolds, which can serve as basis for tissue reconstruction...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28619301/the-effects-of-gua-sha-on-symptoms-and-inflammatory-biomarkers-associated-with-chronic-low-back-pain-a-randomized-active-controlled-crossover-pilot-study-in-elderly
#6
John W M Yuen, William W N Tsang, Sonny H M Tse, Wings T Y Loo, Suk-Tak Chan, Diana L Y Wong, Hilary H Y Chung, Jacky K K Tam, Thomas K S Choi, Vico C L Chiang
OBJECTIVE: To address the challenges for trialing with elderly and the lacking of valid sham/placebo control, a randomized crossover pilot study is designed and its feasibility on elderly subjects is evaluated. DESIGN: A pilot randomized crossover study was conducted with hydrocollator-based hot pack therapy as active control. Pain intensity, physical disability, depression, general health status, and salivary biomarkers were assessed as outcome measures. RESULTS: Despite there was no significant difference observed between any outcome measures attained by the two interventions, several important differences were noted during the one-week follow-up period...
June 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28618342/monitoring-breast-cancer-treatment-using-a-fourier-transform-infrared-spectroscopy-based-computational-model
#7
J Depciuch, E Kaznowska, S Golowski, A Koziorowska, I Zawlik, M Cholewa, K Szmuc, J Cebulski
Breast cancer affects one in four women, therefore, the search for new diagnostic technologies and therapeutic approaches is of critical importance. This involves the development of diagnostic tools to facilitate the detection of cancer cells, which is useful for assessing the efficacy of cancer therapies. One of the major challenges for chemotherapy is the lack of tools to monitor efficacy during the course of treatment. Vibrational spectroscopy appears to be a promising tool for such a purpose, as it yields Fourier transformation infrared (FTIR) spectra which can be used to provide information on the chemical composition of the tissue...
June 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28606818/investigating-unlicensed-retail-drug-vendors-preparedness-and-knowledge-about-malaria-an-exploratory-study-in-rural-uganda
#8
Eric Liow, Rosemin Kassam, Richard Sekiwunga
BACKGROUND: Despite major efforts to increase the uptake of preventive measures and timely use of the first line antimalarial treatment artemisinin-based combination therapies (ACT), Uganda continues to fall short of meeting its national malaria control targets. One of the challenges has been scaling up effective measures in rural and remote areas where the unlicensed private retail sector remains the first point of contact and a common source of treatment. The current paper discusses unlicensed vendors' (1) training related to malaria case management for children aged five and under, and (2) knowledge related to the cause of malaria, preventive measures, common signs, and symptoms, diagnostic procedures, and best treatment options...
June 9, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28595612/responsiveness-and-minimal-important-change-of-the-norwegian-version-of-the-disabilities-of-the-arm-shoulder-and-hand-questionnaire-dash-in-patients-with-subacromial-pain-syndrome
#9
Tarjei Rysstad, Yngve Røe, Benjamin Haldorsen, Ida Svege, Liv Inger Strand
BACKGROUND: The Disabilities of the Arm, Shoulder, and Hand questionnaire (DASH) is a valid and reliable patient-reported outcome measure (PROM). It was designed to measure physical disability and symptoms in patients with musculoskeletal disorders of the upper extremity, and is one of the most commonly used PROMs for patients with shoulder pain. The aim of this study was to examine responsiveness, the smallest detectable change (SDC) and the minimal important change (MIC) of the DASH, in line with international (COSMIN) recommendations...
June 8, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28590796/noninvasive-therapy-for-osteoid-osteoma-a-prospective-developmental-study-with-mr-imaging-guided-high-intensity-focused-ultrasound
#10
Alessandro Napoli, Alberto Bazzocchi, Roberto Scipione, Michele Anzidei, Luca Saba, Pejman Ghanouni, Denis A Cozzi, Carlo Catalano
Purpose To demonstrate that magnetic resonance (MR) imaging-guided high-intensity focused ultrasound (HIFU) is a safe, effective, and durable treatment option for the management of osteoid osteoma in children and young adults. Materials and Methods This prospective study was institutional review board approved and is registered with clinicaltrials.gov (identification number NCT02302651). Written informed consent was obtained from patients or their parents. Patients who had both clinical and radiologic findings that were diagnostic for nonvertebral osteoid osteoma and no contraindications to MR imaging-guided HIFU were enrolled between June 2010 and June 2013...
June 7, 2017: Radiology
https://www.readbyqxmd.com/read/28588307/irisin-prevents-and-restores-bone-loss-and-muscle-atrophy-in-hind-limb-suspended-mice
#11
Graziana Colaianni, Teresa Mongelli, Concetta Cuscito, Paolo Pignataro, Luciana Lippo, Giovanna Spiro, Angela Notarnicola, Ilenia Severi, Giovanni Passeri, Giorgio Mori, Giacomina Brunetti, Biagio Moretti, Umberto Tarantino, Silvia C Colucci, Janne E Reseland, Roberto Vettor, Saverio Cinti, Maria Grano
We previously showed that Irisin, a myokine released from skeletal muscle after physical exercise, plays a central role in the control of bone mass. Here we report that treatment with recombinant Irisin prevented bone loss in hind-limb suspended mice when administered during suspension (preventive protocol) and induced recovery of bone mass when mice were injected after bone loss due to a suspension period of 4 weeks (curative protocol). MicroCT analysis of femurs showed that r-Irisin preserved both cortical and trabecular bone mineral density, and prevented a dramatic decrease of the trabecular bone volume fraction...
June 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28586949/phase-1-2-trial-of-5-fraction-stereotactic-radiosurgery-with-5-mm-margins-with-concurrent-and-adjuvant-temozolomide-in-newly%C3%A2-diagnosed-supratentorial-glioblastoma-health-related-quality-of-life-results
#12
Erqi L Pollom, Dylann Fujimoto, Jacob Wynne, Kira Seiger, Leslie A Modlin, Lisa R Jacobs, Melissa Azoulay, Rie von Eyben, Laurie Tupper, Iris C Gibbs, Steven L Hancock, Gordon Li, Steven D Chang, John R Adler, Griffith R Harsh, Ciara Harraher, Seema Nagpal, Reena P Thomas, Lawrence D Recht, Clara Y H Choi, Scott G Soltys
PURPOSE: We report a longitudinal assessment of health-related quality of life (HRQOL) in patients with glioblastoma (GBM) treated on a prospective dose escalation trial of 5-fraction stereotactic radiosurgery (25-40 Gy in 5 fractions) with concurrent and adjuvant temozolomide. METHODS: HRQOL was assessed using the European Organization for Research and Treatment of Cancer (EORTC) quality of life questionnaire core-30 (QLQ-C30) general, the EORTC quality of life questionnaire-brain cancer specific module (QLQ-BN20), and the M...
May 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28583145/influences-of-de-qi-induced-by-acupuncture-on-immediate-and-accumulated-analgesic-effects-in-patients-with-knee-osteoarthritis-study-protocol-for-a-randomized-controlled-trial
#13
Min Li, Hongwen Yuan, Pei Wang, Siyuan Xin, Jie Hao, Miaomiao Liu, Jinfeng Li, Man Yu, Xinrui Zhang
BACKGROUND: De Qi is a special sensational response upon acupuncture needling. According to traditional acupuncture theory, the treatment is "effective only after Qi arrival"; that is, De Qi is an important indicator of therapeutic efficacy and good prognosis. However, it is still disputable whether De Qi improves the efficacy of acupuncture therapy. This prospective, randomized controlled trial aims to explore the influence of De Qi induced by acupuncture on immediate and accumulated analgesic effects in patients with knee osteoarthritis (KOA)...
June 5, 2017: Trials
https://www.readbyqxmd.com/read/28578691/acute-and-chronic-effects-of-aerobic-exercise-on-blood-pressure-in-resistant-hypertension-study-protocol-for-a-randomized-controlled-trial
#14
L S Nascimento, A C Santos, Jms Lucena, Lgo Silva, Aem Almeida, M S Brasileiro-Santos
BACKGROUND: Resistant hypertension is a specific condition that affects approximately 10% of subjects with hypertension, and is characterized by persistently high blood pressure levels even using therapy of three or more antihypertensive agents or with blood pressure control using therapy with four or more antihypertensive agents. Changes in lifestyle, such as physical exercise, are indicated for controlling blood pressure. However, investigating studies about this therapy in individuals with resistant hypertension are few...
June 2, 2017: Trials
https://www.readbyqxmd.com/read/28574316/imaging-of-congenital-torticollis-in-infants-a-retrospective-study-of-an-institutional-protocol
#15
Nicholas Boyko, Melissa Ann Eppinger, Deborah Straka-DeMarco, Catherine Anne Mazzola
OBJECTIVE The authors' objectives in this study were to evaluate their institutional protocol and create recommendations for radiographic imaging in infants with torticollis, with or without plagiocephaly, based on a retrospective clinical analysis and literature review. METHODS A retrospective analysis was conducted to identify infants with torticollis who were evaluated by the craniofacial team. The following patients were identified: those who underwent imaging in the form of radiography, CT scanning, or MRI; those who had a secondary diagnosis or additional clinical finding as the indication for imaging; and those with persistent torticollis despite completion of recommended repositioning techniques and physical therapy (PT)...
June 2, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28570966/enhancing-quality-of-life-among-adolescents-with-bipolar-disorder-a-randomized-trial-of-two-psychosocial-interventions
#16
Lisa A O'Donnell, David A Axelson, Robert A Kowatch, Christopher D Schneck, Catherine A Sugar, David J Miklowitz
BACKGROUND: Adolescents with bipolar disorder (BD) report lower quality of life (QoL) than adolescents with other psychiatric disorders. This study compared the efficacy of family-focused therapy for adolescents (FFT-A) plus pharmacotherapy to brief psychoeducation (enhanced care, or EC) plus pharmacotherapy on self-rated QoL in adolescents with BD over 2 years. METHODS: Participants were 141 adolescents (mean age: 15.6±1.4yr) with BD I or II who had a mood episode in the previous 3 months...
April 28, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28557581/quality-of-life-in-youth-with-obstructive-sleep-apnea-syndrome-osas-treated-with-continuous-positive-airway-pressure-cpap-therapy
#17
Mary K Lynch, Lindsey C Elliott, Kristin T Avis, David C Schwebel, Burel R Goodin
OBJECTIVE/BACKGROUND: Improvement is sought for youth with obstructive sleep apnea syndrome (OSAS) who have poor quality of life (QoL), which resolves somewhat following treatment. One mitigating factor in improved QoL following treatment may be adherence to the CPAP protocol, which presents a barrier to most youth. This study explored relations between CPAP adherence and QoL in youth with OSAS. PARTICIPANTS: We recruited 42 youth-caregiver dyads in which youth between the ages of 8 and 16 years were diagnosed with OSAS and required CPAP use as part of their treatment plan...
May 30, 2017: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/28554939/simplified-clinical-algorithm-for-identifying-patients-eligible-for-immediate-initiation-of-antiretroviral-therapy-for-hiv-slate-protocol-for-a-randomised-evaluation
#18
Sydney Rosen, Matthew P Fox, Bruce A Larson, Alana T Brennan, Mhairi Maskew, Isaac Tsikhutsu, Margaret Bii, Peter D Ehrenkranz, Wd Francois Venter
INTRODUCTION: African countries are rapidly adopting guidelines to offer antiretroviral therapy (ART) to all HIV-infected individuals, regardless of CD4 count. For this policy of 'treat all' to succeed, millions of new patients must be initiated on ART as efficiently as possible. Studies have documented high losses of treatment-eligible patients from care before they receive their first dose of antiretrovirals (ARVs), due in part to a cumbersome, resource-intensive process for treatment initiation, requiring multiple clinic visits over a several-week period...
May 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/28554433/systematic-review-of-nondrug-nonsurgical-treatment-of-shoulder-conditions
#19
REVIEW
Cheryl Hawk, Amy L Minkalis, Raheleh Khorsan, Clinton J Daniels, Dennis Homack, Jordan A Gliedt, Julie A Hartman, Shireesh Bhalerao
OBJECTIVE: The purpose of this review was to evaluate the effectiveness of conservative nondrug, nonsurgical interventions, either alone or in combination, for conditions of the shoulder. METHODS: The review was conducted from March 2016 to November 2016 in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), and was registered with PROSPERO. Eligibility criteria included randomized controlled trials (RCTs), systematic reviews, or meta-analyses studying adult patients with a shoulder diagnosis...
May 26, 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28537001/study-design-of-vesuto-%C3%A2-efficacy-of-tiotropium-olodaterol-on-lung-hyperinflation-exercise-capacity-and-physical-activity-in-japanese-patients-with-chronic-obstructive-pulmonary-disease
#20
Masakazu Ichinose, Yoshiaki Minakata, Takashi Motegi, Jun Ueki, Tetsuo Seki, Tatsuhiko Anzai, Ayako Takizawa, Lars Grönke, Kazuto Hirata
INTRODUCTION: The superiority of tiotropium/olodaterol is demonstrated in improvement of lung function, dyspnea, lung hyperinflation, and quality of life compared with either monotherapy in patients with chronic obstructive pulmonary disease (COPD). Japanese Respiratory Society Guidelines for COPD management include improvement of exercise tolerance and daily physical activity as the treatment goals; however, there is limited evidence in Japanese patients with COPD. METHODS: A protocol is developed for the VESUTO(®) study that investigates the efficacy of tiotropium/olodaterol fixed-dose combination (FDC) compared with tiotropium alone on inspiratory capacity (IC, volume from functional residual capacity to total lung capacity), exercise capacity, and daily physical activity in Japanese patients with COPD...
May 23, 2017: Advances in Therapy
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