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https://www.readbyqxmd.com/read/29777913/the-tp53-induced-glycolysis-and-apoptosis-regulator-mediates-cooperation-between-htlv-1-p30-ii-and-the-retroviral-oncoproteins-tax-and-hbz-and-is-highly-expressed-in-an-in-vivo-xenograft-model-of-htlv-1-induced-lymphoma
#1
Tetiana Hutchison, Aditi Malu, Laçin Yapindi, Rachel Bergeson, Kendra Peck, Megan Romeo, Carolyn Harrod, Jordan Pope, Louisa Smitherman, Wesleigh Gwinn, Lee Ratner, Courtney Yates, Robert Harrod
The human T-cell leukemia virus type-1 (HTLV-1) is an oncoretrovirus that infects and transforms CD4+ T-cells and causes adult T-cell leukemia/lymphoma (ATLL) -an aggressive lymphoproliferative disease that is highly refractive to most anticancer therapies. The HTLV-1 proviral genome encodes several regulatory products within a conserved 3' nucleotide sequence, known as pX; however, it remains unclear how these factors might cooperate or dynamically interact in virus-infected cells. Here we demonstrate that the HTLV-1 latency-maintenance factor p30II induces the TP53-induced glycolysis and apoptosis regulator (TIGAR) and counters the oxidative stress, mitochondrial damage, and cytotoxicity caused by the viral oncoproteins Tax and HBZ...
May 16, 2018: Virology
https://www.readbyqxmd.com/read/29777381/utility-of-mayo-clinic-s-early-screen-for-discharge-planning-tool-for-predicting-patient-length-of-stay-discharge-destination-and-readmission-risk-in-an-inpatient-oncology-cohort
#2
Caitlyn P Socwell, Lucy Bucci, Sharni Patchell, Erika Kotowicz, Lara Edbrooke, Rodney Pope
PURPOSE: To examine the feasibility of using the Mayo Clinic's Early Screen for Discharge Planning (ESDP) tool in determining its predictive ability in an inpatient oncology hospital setting for variables including length of stay (LOS), discharge destination, and readmission risk. METHODS: A prospective observational study was conducted at a metropolitan tertiary cancer centre in Melbourne, Australia. The ESDP score, along with patient outcomes and characteristics, were collected to examine the relationships between positive and negative ESDP scores and patient outcomes...
May 18, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29768117/experiences-and-expectations-of-bereavement-contact-among-caregivers-of-patients-with-advanced-cancer
#3
Maisam Makarem, Shan Mohammed, Nadia Swami, Ashley Pope, Nanor Kevork, Monika Krzyzanowska, Gary Rodin, Breffni Hannon, Camilla Zimmermann
BACKGROUND: Contact with bereaved caregivers is not standard practice among cancer physicians, and little is known about its impact on caregivers. OBJECTIVE: Our aim was to describe the experiences and opinions of caregivers regarding bereavement contact from healthcare providers (HCP). DESIGN: Semistructured qualitative interviews were conducted with 61 bereaved caregivers. SUBJECTS: Bereaved caregivers of advanced cancer patients who had completed a randomized controlled trial of an early palliative care intervention were approached one to five years after the patient's death...
May 16, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29747994/a-systematic-review-of-viral-exposures-as-a-risk-for-rheumatoid-arthritis
#4
F M Kudaeva, M R Speechley, J E Pope
OBJECTIVE: Different viral exposures have been implicated in the etiology of rheumatoid arthritis (RA). Evidence relating to the association between putative viral exposures and the development of RA was reviewed. METHODS: A systematic literature search was conducted using MEDLINE-OVID, EMBASE-OVID, PUBMED and Cochrane library databases. Articles were included if they were case-controls, cross-sectional or cohort studies and were published in English. Case-series were included if there was a lack of other study designs...
March 21, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29747066/spontaneous-dna-damage-to-the-nuclear-genome-promotes-senescence-redox-imbalance-and-aging
#5
Andria R Robinson, Matthew J Yousefzadeh, Tania A Rozgaja, Jin Wang, Xuesen Li, Jeremy S Tilstra, Chelsea H Feldman, Siobhán Q Gregg, Caroline H Johnson, Erin M Skoda, Marie-Céline Frantz, Harris Bell-Temin, Hannah Pope-Varsalona, Aditi U Gurkar, Luigi A Nasto, Renã A S Robinson, Heike Fuhrmann-Stroissnigg, Jolanta Czerwinska, Sara J McGowan, Nadiezhda Cantu-Medellin, Jamie B Harris, Salony Maniar, Mark A Ross, Christy E Trussoni, Nicholas F LaRusso, Eugenia Cifuentes-Pagano, Patrick J Pagano, Barbara Tudek, Nam V Vo, Lora H Rigatti, Patricia L Opresko, Donna B Stolz, Simon C Watkins, Christin E Burd, Claudette M St Croix, Gary Siuzdak, Nathan A Yates, Paul D Robbins, Yinsheng Wang, Peter Wipf, Eric E Kelley, Laura J Niedernhofer
Accumulation of senescent cells over time contributes to aging and age-related diseases. However, what drives senescence in vivo is not clear. Here we used a genetic approach to determine if spontaneous nuclear DNA damage is sufficient to initiate senescence in mammals. Ercc1-/∆ mice with reduced expression of ERCC1-XPF endonuclease have impaired capacity to repair the nuclear genome. Ercc1-/∆ mice accumulated spontaneous, oxidative DNA damage more rapidly than wild-type (WT) mice. As a consequence, senescent cells accumulated more rapidly in Ercc1-/∆ mice compared to repair-competent animals...
April 13, 2018: Redox Biology
https://www.readbyqxmd.com/read/29744642/gadolinium-deposition-within-the-paediatric-brain-no-increased-intrinsic-t1-weighted-signal-intensity-within-the-dentate-nucleus-following-the-administration-of-a-minimum-of-four-doses-of-the-macrocyclic-agent-gadobutrol
#6
Jonathan R Young, Joe Qiao, Iren Orosz, Noriko Salamon, Mark A Franke, Hyun J Kim, Whitney B Pope
OBJECTIVES: To determine whether repeated administration of the macrocyclic gadolinium-based contrast agent (GBCA) gadobutrol in children is associated with T1-weighted hyperintensity within the dentate nucleus, an imaging surrogate for gadolinium deposition. METHODS: With institutional review board approval, we identified a cohort of eight patients aged 18 years or younger who underwent at least four gadobutrol-enhanced magnetic resonance imaging (MRI) examinations of the brain from 2013 to 2017...
May 9, 2018: European Radiology
https://www.readbyqxmd.com/read/29743308/performance-evaluation-of-a-prototype-architect-antibody-assay-for-babesia-microti
#7
Kevin Cheng, Kelly E Coller, Christopher C Marohnic, Zachary A Pfeiffer, James R Fino, Randee R Elsing, Janet Bergsma, Marilee A Marcinkus, Alak K Kar, Orlando H Gumbs, Kathy S Otis, Jeffrey Fishpaugh, Phillip W Schultz, Mark R Pope, Alfredo R Narvaez, Susan J Wong, Susan Madison-Antenucci, Thomas P Leary, George J Dawson
The tick-borne protozoan Babesia microti is responsible for more than 200 cases of transfusion-transmitted babesiosis (TTB) infection in the United States over the last 30 years. Measures to mitigate the risk of TTB include nucleic acid testing (NAT) and B. microti antibody testing. A fully automated prototype B. microti antibody test was developed on the ARCHITECT instrument. The specificity was determined to be 99.98% in volunteer blood donors (n=28,740) from areas considered as low endemic for B. microti The sensitivity of the prototype test was studied in experimentally-infected macaques; a total of 128 samples were detected compared to 125 with the indirect fluorescent antibody test (IFA), additionally, 83 (89...
May 9, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29740953/recent-violence-and-legal-involvement-among-young-adults-with-early-psychosis-enrolled-in-coordinated-specialty-care
#8
Stephanie A Rolin, Leslie A Marino, Leah G Pope, Michael T Compton, Rufina J Lee, Barry Rosenfeld, Merrill Rotter, Ilana Nossel, Lisa Dixon
AIM: Individuals with serious mental illnesses have a small increased risk of engaging in violence or legal involvement compared to the general population. This seems to be particularly true for young adults experiencing early stages of psychosis. This study analysed the prevalence of and risk factors for reports of violence and legal involvement in a sample of young adults receiving Coordinated Specialty Care for early non-affective psychosis. METHODS: A total of 373 young adults (ages 16-30) within 2 years of the onset of non-affective psychosis were enrolled in 10 Coordinated Specialty Care sites in New York State from October 2013 to August 2016...
May 9, 2018: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29738229/arginine-containing-surfactant-like-peptides-interaction-with-lipid-membranes-and-antimicrobial-activity
#9
Valeria Castelletto, Ruth H Barnes, Kimon-Andreas Karatzas, Charlotte J C Edwards-Gayle, Francesca Greco, Ian W Hamley, Robert Rambo, Jani Seitsonen, Janne Ruokolainen
The activity of antimicrobial peptides stems from their interaction with bacterial membranes, which are disrupted according to a number of proposed mechanisms. Here, we investigate the interaction of a model antimicrobial peptide that contains a single arginine residue with vesicles containing model lipid membranes. The surfactant-like peptide Ala6-Arg (A6R) is studied in the form where both termini are capped (CONH-A6R-NH2, capA6R) or uncapped (NH2-A6R-OH, A6R). Lipid membranes are selected to correspond to model anionic membranes (POPE/POPG) resembling those in bacteria or model zwitterionic membranes (POPC/DOPC) similar to those found in mammalian cells...
May 8, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29733552/safety-of-tnf-inhibitors-in-pregnancy
#10
EDITORIAL
Janet E Pope
Nearly half of all pregnancies are not planned so inadvertent drug exposure is a reality in women with chronic inflammatory diseases (1). Patients taking medications for their rheumatic diseases during pregnancy, and their physicians may perceive the stakes to be high. There are two patients to consider. We need to accurately advise our pregnant patients with the most updated information weighing trade-offs of disease flares from stopping medications where disease activity can result in prematurity vs. potential drug effects which can also be associated with negative pregnancy outcomes This article is protected by copyright...
May 7, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29726883/electronic-effects-and-fundamental-physics-studied-in-molecular-interfaces
#11
Thomas Pope, Shixuan Du, Hong-Jun Gao, Werner A Hofer
Scanning probe instruments in conjunction with a very low temperature environment have revolutionized the ability of building, functionalizing, and analysing two dimensional interfaces in the last twenty years. In addition, the availability of fast, reliable, and increasingly sophisticated methods to simulate the structure and dynamics of these interfaces allow us to capture even very small effects at the atomic and molecular level. In this review we shall focus largely on metal surfaces and organic molecular compounds and show that building systems from the bottom up and controlling the physical properties of such systems is no longer within the realm of the desirable, but has become day to day reality in our best laboratories...
May 4, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29725622/somatic-gnaq-mutation-in-the-forme-fruste-of-sturge-weber-syndrome
#12
Michael S Hildebrand, A Simon Harvey, Stephen Malone, John A Damiano, Hongdo Do, Zimeng Ye, Lara McQuillan, Wirginia Maixner, Renate Kalnins, Bernadette Nolan, Martin Wood, Ezgi Ozturk, Nigel C Jones, Greta Gillies, Kate Pope, Paul J Lockhart, Alexander Dobrovic, Richard J Leventer, Ingrid E Scheffer, Samuel F Berkovic
Objective: To determine whether the GNAQ R183Q mutation is present in the forme fruste cases of Sturge-Weber syndrome (SWS) to establish a definitive molecular diagnosis. Methods: We used sensitive droplet digital PCR (ddPCR) to detect and quantify the GNAQ mutation in tissues from epilepsy surgery in 4 patients with leptomeningeal angiomatosis; none had ocular or cutaneous manifestations. Results: Low levels of the GNAQ mutation were detected in the brain tissue of all 4 cases-ranging from 0...
June 2018: Neurology. Genetics
https://www.readbyqxmd.com/read/29723995/comparing-the-effects-of-different-body-armor-systems-on-the-occupational-performance-of-police-officers
#13
Ben Schram, Robin Orr, Rodney Pope, Ben Hinton, Geoff Norris
Policing duties may inherently be dangerous due to stab, blunt trauma and ballistic threats. The addition of individual light armor vests (ILAVs) has been suggested as a means to protect officers. However, the addition of the extra load of the ILAV may affect officer ability to conduct occupational tasks. The purpose of this study was to determine if wearing any of three different ILAVs made by different companies with their preferred materials and designs (ILAV A, 4.68 percent body weight, ILAV B, 4.05 percent body weight, & ILAV C, 3...
May 1, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29723135/exploring-the-self-compassion-of-health-care-social-workers-how-do-they-fare
#14
Joann Lianekhammy, J Jay Miller, Jacquelyn Lee, Natalie Pope, Sheila Barnhart, Erlene Grise-Owens
Indubitably, the challenges facing health-care social workers are becoming increasingly complex. Whilst these problematic professional circumstances compound the need for self-compassion among health-care social workers, few studies, if any, have explicitly examined self-compassion among this practitioner group. This cross-sectional study explored self-compassion among a sample of practitioners (N = 138) in one southeastern state. Results indicate that health-care social workers in this sample engage in self-compassion only moderately...
May 3, 2018: Social Work in Health Care
https://www.readbyqxmd.com/read/29722661/phase-2-study-of-bortezomib-combined-with-temozolomide-and-regional-radiation-therapy-for-upfront-treatment-of-patients-with-newly-diagnosed-glioblastoma-multiforme-safety-and-efficacy-assessment
#15
Xiao-Tang Kong, Nhung T Nguyen, Yoon J Choi, Guicheng Zhang, HuyTram N Nguyen, Emese Filka, Stacey Green, William H Yong, Linda M Liau, Richard M Green, Tania Kaprealian, Whitney B Pope, P Leia Nghiemphu, Timothy Cloughesy, Andrew Lassman, Albert Lai
PURPOSE: To assess the safety and efficacy of upfront treatment using bortezomib combined with standard radiation therapy (RT) and temozolomide (TMZ), followed by adjuvant bortezomib and TMZ for ≤24 cycles, in patients with newly diagnosed glioblastoma multiforme (GBM). METHODS AND MATERIALS: Twenty-four patients with newly diagnosed GBM were enrolled. The patients received standard external beam regional RT with concurrent TMZ beginning 3 to 6 weeks after surgery, followed by adjuvant TMZ and bortezomib for ≤24 cycles or until tumor progression...
April 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29705775/the-effect-of-age-and-body-mass-index-on-the-surgical-anatomy-of-supraumbilical-port-insertion-implications-for-laparoscopic-and-robotic-surgery
#16
Mohamed A Bedaiwy, Paul J Yong, Tarek A Farghaly, Faten F Abdelhafez, Justin Tan, Rachel Pope, William W Hurd, James H Liu, Kristine Zanotti
BACKGROUND: Minimally invasive surgery is the preferred approach for performing many gynecologic procedures. Occasionally, supraumbilical port placement may be preferable to optimize visibility and maneuverability although the risks of complications are less well characterized compared to umbilical entry. METHODS: We conducted a retrospective review of computed tomograms from 92 patients to evaluate the anatomic considerations for umbilical and supraumbilical port entry based on patient age, body mass index (BMI), parity, abdominal wall thickness, and distance to the great vessels...
April 27, 2018: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29705666/the-pre-assembled-state-of-magainin-2-lysine-linked-dimer-determines-its-enhanced-antimicrobial-activity
#17
Esteban N Lorenzón, Thatyane M Nobre, Luciano Caseli, Eduardo M Cilli, Gabriel C A da Hora, Thereza A Soares, Osvaldo N Oliveira
Antimicrobial peptides (AMPs) are alternatives to conventional antibiotics against multi-drug resistant bacteria with low potential for developing microbial resistance. The design of such molecules requires understanding of the mechanisms of action, particularly the interaction with bacteria cell membranes. In this work, we determine the mechanism responsible for the higher activity against Escherichia coli of the C-terminal lysine dimer of magainin 2, (MG2)2 K, in comparison to the monomeric peptide magainin 2 (MG2)...
April 20, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29703630/mid-to-long-term-survivorship-of-oxidised-zirconium-total-knee-replacements-performed-in-patients-under-50years-of-age
#18
Alexander W Glover, Alasdair J A Santini, John S Davidson, Jill A Pope
BACKGROUND: Oxidised zirconium has the wear properties of ceramic with the breakage resistance of metal. This results in less wear and is of benefit to younger, higher demand patients. We report the short- to mid-term survival of 103 Profix zirconium total knee replacements performed in patients under 50years of age at time of surgery. METHODS: Data was collected prospectively and survival analysis undertaken with strict end points used. SF (Short Form) 12 and WOMAC (Western Ontario and McMaster University) scores were recorded at pre-operatively and at twelve months, one, three, five, seven and ten years...
April 24, 2018: Knee
https://www.readbyqxmd.com/read/29702131/electronic-cigarette-substitution-in-the-experimental-tobacco-marketplace-a-review
#19
Warren K Bickel, Derek A Pope, Brent A Kaplan, W Brady DeHart, Mikhail N Koffarnus, Jeffrey S Stein
The evolution of science derives, in part, from the development and use of new methods and techniques. Here, we discuss one development that may have impact on the understanding of tobacco regulatory science: namely, the application of behavioral economics to the complex tobacco marketplace. The purpose of this paper is to review studies that examine conditions impacting the degree to which electronic nicotine delivery system (ENDS) products substitute for conventional cigarettes in the Experimental Tobacco Marketplace (ETM)...
April 24, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29696946/conventional-and-advanced-magnetic-resonance-imaging-in-patients-with-high-grade-glioma
#20
Whitney B Pope, Garth Brandal
Magnetic resonance imaging is integral to the care of patients with high grade gliomas. Anatomic detail can be acquired with conventional structural imaging, but newer approaches also add capabilities to interrogate image-derived physiologic and molecular characteristics of central nervous system neoplasms. These advanced imaging techniques are increasingly employed to generate biomarkers that better reflect tumor burden and therapy response. The following is an overview of current strategies based on advanced magnetic resonance imaging that are used in the assessment of high grade glioma patients with an emphasis on how novel imaging biomarkers can potentially advance patient care...
April 26, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
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