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https://www.readbyqxmd.com/read/29351780/fancm-and-recql-genetic-variants-and-breast-cancer-susceptibility-relevance-to-south-poland-and-west-ukraine
#1
Tú Nguyen-Dumont, Aleksander Myszka, Pawel Karpinski, Maria M Sasiadek, Hayane Akopyan, Fleur Hammet, Helen Tsimiklis, Daniel J Park, Bernard J Pope, Ryszard Slezak, Nataliya Kitsera, Aleksandra Siekierzynska, Melissa C Southey
BACKGROUND: FANCM and RECQL have recently been reported as breast cancer susceptibility genes and it has been suggested that they should be included on gene panel tests for breast cancer predisposition. However, the clinical value of testing for mutations in RECQL and FANCM remains to be determined. In this study, we have characterised the spectrum of FANCM and RECQL mutations in women affected with breast or ovarian cancer from South-West Poland and West Ukraine. METHODS: We applied Hi-Plex, an amplicon-based enrichment method for targeted massively parallel sequencing, to screen the coding exons and proximal intron-exon junctions of FANCM and RECQL in germline DNA from unrelated women affected with breast cancer (n = 338) and ovarian cancer (n = 89) from Poland (n = 304) and Ukraine (n = 123)...
January 19, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29346744/2017-national-standards-for-diabetes-self-management-education-and-support
#2
Joni Beck, Deborah A Greenwood, Lori Blanton, Sandra T Bollinger, Marcene K Butcher, Jo Ellen Condon, Marjorie Cypress, Priscilla Faulkner, Amy Hess Fischl, Theresa Francis, Leslie E Kolb, Jodi M Lavin-Tompkins, Janice MacLeod, Melinda Maryniuk, Carolé Mensing, Eric A Orzeck, David D Pope, Jodi L Pulizzi, Ardis A Reed, Andrew S Rhinehart, Linda Siminerio, Jing Wang
Purpose The purpose of this study is to review the literature for Diabetes Self-Management Education and Support (DSMES) to ensure the National Standards for DSMES (Standards) align with current evidence-based practices and utilization trends. Methods The 10 Standards were divided among 20 interdisciplinary workgroup members. Members searched the current research for diabetes education and support, behavioral health, clinical, health care environment, technical, reimbursement, and business practice for the strongest evidence that guided the Standards revision...
February 2018: Diabetes Educator
https://www.readbyqxmd.com/read/29341069/reliability-and-validity-of-iscoreb-instrument-for-scoring-clinical-outcomes-of-research-for-epidermolysis-bullosa
#3
A L Bruckner, D L Fairclough, J A Feinstein, I Lara-Corrales, Anne W Lucky, Jakub Tolar, Elena Pope
BACKGROUND: Epidermolysis bullosa (EB) is a group of rare and currently incurable genetic blistering disorders. As more pathogenic driven therapies are being developed, the need for EB-specific validated outcomes measures designed for use in clinical trials is becoming important. OBJECTIVES: We previously reported on development of an instrument for scoring clinical outcomes of research for Epidermolysis Bullosa (iscorEB), a new combined clinician and patient reported outcomes tool...
January 17, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29339581/strain-induced-bi-thermoelectricity-in-tapered-carbon-nanotubes
#4
Laith A Algharagholy, Tom Pope, Colin J Lambert
We show that carbon-based nanostructured materials are a novel testbed for controlling thermoelectricity and have the potential to underpin the development of new cost-effective environmentally-friendly thermoelectric materials. In single-molecule junctions, it is known that transport resonances associated with the discrete molecular levels play a key role in the thermoelectric performance, but such resonances have not been exploited in carbon nanotubes (CNTs). Here we study junctions formed from tapered CNTs and demonstrate that such structures possess transport resonances near the Fermi level, whose energetic location can be varied by applying strain, resulting in an ability to tune the sign of their Seebeck coefficient...
January 17, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29333947/persistence-of-hepatitis-b-immune-memory-until-9-10%C3%A2-years-of-age-following-hepatitis-b-vaccination-at-birth-and-dtap-ipv-hb-prp%C3%A2-t-vaccination-at-2-4-and-6-months
#5
Pope Kosalaraksa, Kulkanya Chokephaibulkit, Suwat Benjaponpitak, Chitsanu Pancharoen, Sunate Chuenkitmongkol, Siham B'Chir, Xavier Da Costa, Emmanuel Vidor
OBJECTIVE: To evaluate the long-term persistence of anti-hepatitis B surface (HBs) antibodies and the response to a HB challenge re-vaccination in children who had received a primary series of DTaP-IPV-HB-PRP∼T (Hexaxim™) or DTaP-IPV-HB/PRP∼T (Infanrix hexa™). METHODS: Two cohorts of participants who had previously received HB vaccine at birth followed by either DTaP-IPV-HB-PRP∼T or DTaP-IPV-HB/PRP∼T co-administered with PCV7 at 2, 4, 6 months of age in a randomized, Phase III, observer-blind study in Thailand, were followed up for anti-HBs antibodies (geometric mean concentrations [GMCs] and seroprotection [SP] rate [% of participants with a titer ≥10 mIU/mL]) at 12-18 months of age and 9-10 years of age...
January 15, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29330069/conformation-and-trimer-association-of-the-transmembrane-domain-of-the-parainfluenza-virus-fusion-protein-in-lipid-bilayers-from-solid-state-nmr-insights-into-the-sequence-determinants-of-trimer-structure-and-fusion-activity
#6
Myungwoon Lee, Hongwei Yao, Byungsu Kwon, Alan J Waring, Peter Ruchala, Chandan Singh, Mei Hong
Enveloped viruses enter cells by using their fusion proteins to merge the virus lipid envelope and the cell membrane. While crystal structures of the water-soluble ectodomains of many viral fusion proteins have been determined, the structure and assembly of the C-terminal transmembrane domain (TMD) remains poorly understood. Here we use solid-state NMR to determine the backbone conformation and oligomeric structure of the TMD of the parainfluenza virus 5 (PIV5) fusion protein. 13C chemical shifts indicate that the central leucine-rich segment of the TMD is α-helical in POPC/cholesterol membranes and POPE membranes, while the Ile- and Val-rich termini shift to the β-strand conformation in the POPE membrane...
January 9, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29327941/infection-is-not-required-for-mucoinflammatory-lung-disease-in-cftr-knockout-ferrets
#7
Bradley H Rosen, T Idil Apak Evans, Shashanna R Moll, Jaimie S Gray, Bo Liang, Xingshen Sun, Yulong Zhang, Chandler W Jensen-Cody, Anthony M Swatek, Weihong Zhou, Nan He, Pavana G Rotti, Scott R Tyler, Nicholas W Keiser, Preston J Anderson, Leonard Brooks, Yalan Li, R Marshall Pope, Maheen Rajput, Eric A Hoffman, Kai Wang, J Kirk Harris, Kalpaj R Parekh, Katherine N Gibson-Corley, John F Engelhardt
RATIONALE: Classical interpretation of cystic fibrosis (CF) lung disease pathogenesis suggests that infection initiates disease progression, leading to an exuberant inflammatory response, excessive mucus, and ultimately bronchiectasis. While symptomatic antibiotic treatment controls lung infections early in disease, life-long bacterial residence typically ensues. Processes that control the establishment of persistent bacteria in the CF lung, and the contribution of non-infectious components to disease pathogenesis, are poorly understood...
January 12, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29327640/who-should-be-responsible-for-supporting-individuals-with-mental-health-problems-a-critical-literature-review
#8
Megan A Pope, Ashok K Malla, Srividya N Iyer
BACKGROUND: Individuals with mental health problems have many support needs that are often inadequately met; however, perceptions of who should be responsible for meeting these needs have been largely unexplored. Varying perceptions may influence whether, how, and to what extent relevant stakeholders support individuals with mental health problems. AIMS: To critically evaluate the literature to determine who different stakeholders believe should be responsible for supporting individuals with mental health problems, what factors shape these perceptions, and how they relate to one another...
January 1, 2018: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/29326201/eight-genome-sequences-of-cluster-be1-phages-that-infect-streptomyces-species
#9
Lee E Hughes, Christopher D Shaffer, Vassie C Ware, Issac Aguayo, Rahat M Aziz, Swapan Bhuiyan, Isaac S Bindert, Canyon K Calovich-Benne, Jordyn Chapman, Richard Donegan-Quick, Amal Farooq, Cynthia Garcia, Lee H Graham, Baylee Y Green, Margaret A Kenna, Emily R Kneeream, Christian E Laing, Catherine M Mageeney, Sandra N Meridew, Abigail R Mikolon, Ryann E Morgan, Subhayu Nayek, Idowu D Olugbade, Kim C Pike, Lauren E Schlegel, Taylor C Shishido, Tara Suresh, Nikita Suri, Kathleen Weston Hafer, Rebecca A Garlena, Daniel A Russell, Steven G Cresawn, Welkin H Pope, Deborah Jacobs-Sera, Graham F Hatfull
Cluster BE1 Streptomyces bacteriophages belong to the Siphoviridae, with genome sizes over 130 kbp, and they contain direct terminal repeats of approximately 11 kbp. Eight newly isolated closely related cluster BE1 phages contain 43 to 48 tRNAs, one transfer-messenger RNA (tmRNA), and 216 to 236 predicted open reading frames (ORFs), but few of their genes are shared with other phages, including those infecting Streptomyces species.
January 11, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29326199/genome-sequences-of-four-cluster-p-mycobacteriophages
#10
Erin L Doyle, Christy L Fillman, Nathan S Reyna, Deborah M Tobiason, Daniel E Westholm, Jonathan L Askins, Brittany P Backus, Ashlynn C Baker, Harrison S Ballard, Paul J Bisesi, Logan Bond, Deanna Byrnes, Hannah Carlstedt, Kinnon S Dodson, Megan J Fallert, Kyla J Foster, Daniel N Games, Tristan R Grams, Nancy A Guild, Autumn Hurd, Nicholas Iwata, Cassidy R Kepler, Lucinda R Krenzke, Kelly Luekens, Jackie Lewis, Cali McEntee, Justin C McGee, Noah Nalley, Ruth C Plymale, Jade Prochaska, Reid G Rogers, Jessica B Schipper, Kelsey Snyder, Kali Uhrich, Chelsey D Vermillion, Sarah K Vickers, Meredyth D Wenta, Tyler Z Yates, Chas F Young, Ty H Stoner, Welkin H Pope, Deborah Jacobs-Sera, Rebecca A Garlena, Daniel A Russell, Steven G Cresawn, Graham F Hatfull
Four bacteriophages infecting Mycobacterium smegmatis mc2155 (three belonging to subcluster P1 and one belonging to subcluster P2) were isolated from soil and sequenced. All four phages are similar in the left arm of their genomes, but the P2 phage differs in the right arm. All four genomes contain features of temperate phages.
January 11, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29324836/variation-in-angler-distribution-and-catch-rates-of-stocked-rainbow-trout-in-a-small-reservoir
#11
Brian S Harmon, Dustin R Martin, Christopher J Chizinski, Kevin L Pope
We investigated the spatial and temporal relationship of catch rates and angler party location for two days following a publicly announced put-and-take stocking of rainbow trout (Oncorhynchus mykiss). Catch rates declined with time since stocking and distance from stocking. We hypothesized that opportunity for high catch rates would cause anglers to fish near the stocking location and disperse with time, however distance between angler parties and stocking was highly variable at any given time. Spatially explicit differences in catch rates can affect fishing quality...
2018: PloS One
https://www.readbyqxmd.com/read/29321261/a-model-free-method-for-measuring-dimerization-free-energies-of-clc-ec1-in-lipid-bilayers
#12
Rahul Chadda, Lucy Cliff, Marley Brimberry, Janice L Robertson
The thermodynamic reasons why membrane proteins form stable complexes inside the hydrophobic lipid bilayer remain poorly understood. This is largely because of a lack of membrane-protein systems amenable for equilibrium studies and a limited number of methods for measuring these reactions. Recently, we reported the equilibrium dimerization of the CLC-ec1 Cl-/H+ transporter in lipid bilayers (Chadda et al. 2016. eLife https://doi.org/10.7554/eLife.17438), which provided a new type of model system for studying protein association in membranes...
January 10, 2018: Journal of General Physiology
https://www.readbyqxmd.com/read/29320681/intrinsic-curvature-mediated-transbilayer-coupling-in-asymmetric-lipid-vesicles
#13
Barbara Eicher, Drew Marquardt, Frederick A Heberle, Ilse Letofsky-Papst, Gerald N Rechberger, Marie-Sousai Appavou, John Katsaras, Georg Pabst
We measured the effect of intrinsic lipid curvature, J0, on structural properties of asymmetric vesicles made of palmitoyl-oleoyl-phosphatidylethanolamine (POPE; J0<0) and palmitoyl-oleoyl-phosphatidylcholine (POPC; J0∼0). Electron microscopy and dynamic light scattering were used to determine vesicle size and morphology, and x-ray and neutron scattering, combined with calorimetric experiments and solution NMR, yielded insights into leaflet-specific lipid packing and melting processes. Below the lipid melting temperature we observed strong interleaflet coupling in asymmetric vesicles with POPE inner bilayer leaflets and outer leaflets enriched in POPC...
January 9, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29310768/sjs-ten-2017-building-multidisciplinary-networks-to-drive-science-and-translation
#14
REVIEW
Katie D White, Riichiro Abe, Michael Ardern-Jones, Thomas Beachkofsky, Charles Bouchard, Bruce Carleton, James Chodosh, Ricardo Cibotti, Robert Davis, Joshua C Denny, Roni P Dodiuk-Gad, Elizabeth N Ergen, Jennifer L Goldman, James H Holmes, Shuen-Iu Hung, Mario E Lacouture, Rannakoe J Lehloenya, Simon Mallal, Teri A Manolio, Robert G Micheletti, Caroline M Mitchell, Maja Mockenhaupt, David A Ostrov, Rebecca Pavlos, Munir Pirmohamed, Elena Pope, Alec Redwood, Misha Rosenbach, Michael D Rosenblum, Jean-Claude Roujeau, Arturo P Saavedra, Hajirah N Saeed, Jeffery P Struewing, Hirohiko Sueki, Chonlaphat Sukasem, Cynthia Sung, Jason A Trubiano, Jessica Weintraub, Lisa M Wheatley, Kristina B Williams, Brandon Worley, Wen-Hung Chung, Neil H Shear, Elizabeth J Phillips
Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a life-threatening, immunologically mediated, and usually drug-induced disease with a high burden to individuals, their families, and society with an annual incidence of 1 to 5 per 1,000,000. To effect significant reduction in short- and long-term morbidity and mortality, and advance clinical care and research, coordination of multiple medical, surgical, behavioral, and basic scientific disciplines is required. On March 2, 2017, an investigator-driven meeting was held immediately before the American Academy of Dermatology Annual meeting for the central purpose of assembling, for the first time in the United States, clinicians and scientists from multiple disciplines involved in SJS/TEN clinical care and basic science research...
January 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29305379/short-stay-admissions-at-an-inner-city-hospital-a-cross-sectional-analysis
#15
Ian Pope, Sharif Ismail, Benjamin Bloom, Gwyneth Jansen, Helen Burn, David McCoy, Tim Harris
OBJECTIVE: To investigate factors predictive of short hospital admissions and appropriate placement to inpatient versus clinical decision units (CDUs). METHOD: This is a retrospective analysis of attendance and discharge data from an inner-city ED in England for December 2013. The primary outcome was admission for less than 48 hours either to an inpatient unit or CDU. Variables included: age, gender, ethnicity, deprivation score, arrival date and time, arrival method, admission outcome and discharge diagnosis...
January 5, 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29304549/unravelling-a-mechanism-of-action-of-a-cecropin-a-melittin-hybrid-antimicrobial-peptide-the-induced-formation-of-multilamellar-lipid-stacks
#16
Tânia Silva, Bárbara Claro, Bruno Brás Silva, Nuno Vale, Paula Gomes, Maria Salomé Gomes, Sergio S Funari, Jose Teixeira, Daniela Uhrikova, Margarida Bastos
The understanding of the mechanism of action of antimicrobial peptides is fundamental for the development of new and more active antibiotics. In present work, we use a wide range of techniques (SANS, SAXD, DSC, ITC, CD, confocal and electron microscopy) in order to fully characterize the interaction of a cecropin A-melittin hybrid antimicrobial peptide, CA(1-7)M(2-9), of known antimicrobial activity, with a bacterial model membrane of POPE/POPG, in an effort to unravel its mechanism of action. We found that CA(1-7)M(2-9) disrupts the vesicles inducing membrane condensation, forming an 'onion-like' structure of multilamellar stacks, held together by the intercalated peptides...
January 5, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29303843/cognition-emotional-health-and-immunological-markers-in-children-with-long-term-nonprogressive-hiv
#17
Robert Paul, Tanakorn Apornpong, Wasana Prasitsuebsai, Thanyawee Puthanakit, Vonthanak Saphonn, Linda Aurpibul, Pope Kosalaraksa, Suparat Kanjanavanit, Wicharn Luesomboon, Chaiwat Ngampiyaskul, Tulathip Suwanlerk, Kea Chettra, William T Shearer, Victor Valcour, Jintanat Ananworanich, Stephen Kerr
BACKGROUND: HIV-infected children with long-term nonprogressive disease (LTNPs) eventually convert to a progressive disease type, yet the extent to which these children experience the cognitive and emotional symptoms observed in typical progressive HIV (Progressors) is unknown. METHODS: Eighty-eight LTNPs, 53 Progressors, and 323 healthy controls completed annual assessments of cognitive and emotional health as part of a prospective study. The two HIV-infected groups and the healthy controls were matched on age and sex distribution at enrollment...
January 4, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29301143/prostate-specific-antigen-velocity-in-a-prospective-prostate-cancer-screening-study-of-men-with-genetic-predisposition
#18
Christos Mikropoulos, Christina G Hutten Selkirk, Sibel Saya, Elizabeth Bancroft, Emily Vertosick, Tokhir Dadaev, Charles Brendler, Elizabeth Page, Alexander Dias, D Gareth Evans, Jeanette Rothwell, Lovise Maehle, Karol Axcrona, Kate Richardson, Diana Eccles, Thomas Jensen, Palle J Osther, Christi J van Asperen, Hans Vasen, Lambertus A Kiemeney, Janneke Ringelberg, Cezary Cybulski, Dominika Wokolorczyk, Rachel Hart, Wayne Glover, Jimmy Lam, Louise Taylor, Monica Salinas, Lidia Feliubadaló, Rogier Oldenburg, Ruben Cremers, Gerald Verhaegh, Wendy A van Zelst-Stams, Jan C Oosterwijk, Jackie Cook, Derek J Rosario, Saundra S Buys, Tom Conner, Susan Domchek, Jacquelyn Powers, Margreet Gem Ausems, Manuel R Teixeira, Sofia Maia, Louise Izatt, Rita Schmutzler, Kerstin Rhiem, William D Foulkes, Talia Boshari, Rosemarie Davidson, Marielle Ruijs, Apollonia Tjm Helderman-van den Enden, Lesley Andrews, Lisa Walker, Katie Snape, Alex Henderson, Irene Jobson, Geoffrey J Lindeman, Annelie Liljegren, Marion Harris, Muriel A Adank, Judy Kirk, Amy Taylor, Rachel Susman, Rakefet Chen-Shtoyerman, Nicholas Pachter, Allan Spigelman, Lucy Side, Janez Zgajnar, Josefina Mora, Carole Brewer, Neus Gadea, Angela F Brady, David Gallagher, Theo van Os, Alan Donaldson, Vigdis Stefansdottir, Julian Barwell, Paul A James, Declan Murphy, Eitan Friedman, Nicola Nicolai, Lynn Greenhalgh, Elias Obeid, Vedang Murthy, Lucia Copakova, John McGrath, Soo-Hwang Teo, Sara Strom, Karin Kast, Daniel A Leongamornlert, Anthony Chamberlain, Jenny Pope, Anna C Newlin, Neil Aaronson, Audrey Ardern-Jones, Chris Bangma, Elena Castro, David Dearnaley, Jorunn Eyfjord, Alison Falconer, Christopher S Foster, Henrik Gronberg, Freddie C Hamdy, Oskar Johannsson, Vincent Khoo, Jan Lubinski, Eli Marie Grindedal, Joanne McKinley, Kylie Shackleton, Anita V Mitra, Clare Moynihan, Gad Rennert, Mohnish Suri, Karen Tricker, Sue Moss, Zsofia Kote-Jarai, Andrew Vickers, Hans Lilja, Brian T Helfand, Rosalind A Eeles
BACKGROUND: Prostate-specific antigen (PSA) and PSA-velocity (PSAV) have been used to identify men at risk of prostate cancer (PrCa). The IMPACT study is evaluating PSA screening in men with a known genetic predisposition to PrCa due to BRCA1/2 mutations. This analysis evaluates the utility of PSA and PSAV for identifying PrCa and high-grade disease in this cohort. METHODS: PSAV was calculated using logistic regression to determine if PSA or PSAV predicted the result of prostate biopsy (PB) in men with elevated PSA values...
January 4, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29291418/interrater-reliability-in-interpretation-of-neuropathic-pediatric-urodynamic-tracings-an-expanded-multi-center-study
#19
Anne G Dudley, Mark C Adams, John W Brock, Douglass B Clayton, David B Joseph, Chester J Koh, Paul A Merguerian, John C Pope, Jonathan C Routh, John C Thomas, Duong D Tu, M Chad Wallis, John S Wiener, Elizabeth B Yerkes, Chelsea J Lauderdale, Chevis N Shannon, Stacy T Tanaka
INTRODUCTION: and Objectives: Urodynamics often guide treatment of neuropathic bladder and are reported as objective data points in multi-institutional trials. Urodynamic interpretation, however, can be variable. In a pilot study, pediatric urologists interpreting videourodynamics (VUDS) showed only moderate agreement despite similar training and practice patterns. We hypothesized the pilot study variability would be replicated in a multi-institutional study. METHODS: We developed an anonymous electronic survey that contained twenty scenarios, each with a brief patient history, one urodynamic tracing and fluoroscopic image...
December 29, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29282829/electrochemical-oxidation-of-phosphatidylethanolamines-studied-by-mass-spectrometry
#20
Simone Colombo, Giulia Coliva, Agnieszka Kraj, Jean-Pierre Chervet, Maria Fedorova, Pedro Domingues, M Rosário Domingues
Phosphatidylethanolamines (PEs) are widely present in cellular membranes and lipoproteins. Oxidation of PEs fatty acyl chains generates several oxidized products, exerting a vast number of biological functions, not totally unveiled yet. In vitro biomimetic models have been used to identify oxidized PEs and to develop analytical strategies for their targeted detection in vivo. Most of the models are based on oxidation by reactive oxygen species (ROS), but the oxidative metabolism of PE also relies on controlled reactions catalyzed by enzymes as lipoxygenase (LOX), which can be mimicked by electrochemical (EC) oxidation...
December 28, 2017: Journal of Mass Spectrometry: JMS
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