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https://www.readbyqxmd.com/read/28918602/population-pharmacokinetics-and-optimal-sampling-strategy-for-model-based-precision-dosing-of-melphalan-in-patients-undergoing-hematopoietic-stem-cell-transplantation
#1
Kana Mizuno, Min Dong, Tsuyoshi Fukuda, Sharat Chandra, Parinda A Mehta, Scott McConnell, Elias J Anaissie, Alexander A Vinks
BACKGROUND: High-dose melphalan is an important component of conditioning regimens for patients undergoing hematopoietic stem cell transplantation. The current dosing strategy based on body surface area results in a high incidence of oral mucositis and gastrointestinal and liver toxicity. Pharmacokinetically guided dosing will individualize exposure and help minimize overexposure-related toxicity. OBJECTIVE: The purpose of this study was to develop a population pharmacokinetic model and optimal sampling strategy...
September 16, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28906129/perceptions-of-u-s-veterans-affairs-and-community-healthcare-providers-regarding-cross-system-care-for-heart-failure
#2
Charlene A Pope, Boyd H Davis, Leticia Wine, Lynne S Nemeth, K Sue Haddock, Tom Hartney, R Neal Axon
Objectives This study explores perceptions of US Veterans Affairs (VA) and non-VA healthcare providers caring for Veterans with heart failure (HF) regarding Veteran knowledge and motivations for dual use, provider roles in recommending and coordinating dual use, systems barriers and facilitators, and suggestions for improving cross-system care. Methods Twenty VA and 11 non-VA providers participated in semi-structured interviews, which were analyzed using parallel qualitative content and discourse analysis. Results VA and non-VA providers described variable HF knowledge and self-management among Veterans, and both groups described the need for improved education addressing medication adherence, self-care, and management of acute symptoms...
January 1, 2017: Chronic Illness
https://www.readbyqxmd.com/read/28901210/does-working-memory-impact-functional-outcomes-in-individuals-with-adhd-a-qualitative-and-comprehensive-literature-review
#3
Ronna Fried, Jessica Abrams, Anna Hall, Leah Feinberg, Amanda Pope, Joseph Biederman
OBJECTIVE: Working Memory (WM) is a domain of executive functioning often impaired in individuals with ADHD. Although assumed to cause difficulties across functioning, the scope of impairments from WM deficits in ADHD has not been investigated. The aim of this study was to examine outcomes associated with WM deficits in ADHD. METHOD: We conducted a search of the scientific literature on WM deficits, and Freedom From Distractibility (FFD), in ADHD using PubMed and PsycInfo databases...
September 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28898136/the-relationship-between-accelerometer-determined-physical-activity-and-clinical-low-back-pain-measures-in-adolescents-with-chronic-or-sub-acute-recurrent-low-back-pain
#4
Brent Leininger, Craig Schulz, Zan Gao, Gert Bronfort, Roni Evans, Zachary Pope, Nan Zeng, Mitchell Haas
Study Design Cross-sectional. Background Although low back pain (LBP) occurs commonly in adolescence, little is known about the relationship between objectively measured physical activity and chronic LBP. Objectives Assess the relationship between objective physical activity measures assessed by accelerometers and standard clinical measures (pain intensity, disability, quality of life) in a sample of adolescents with recurrent or chronic LBP. Methods The study used a sub-sample of 143 adolescents, 12 - 18 years of age, from a randomized clinical trial...
September 12, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28892734/acute-change-in-anterior-cingulate-cortex-gaba-but-not-glutamine-glutamate-mediates-antidepressant-response-to-citalopram
#5
Brian P Brennan, Roee Admon, Chris Perriello, Erin M LaFlamme, Alison J Athey, Diego A Pizzagalli, James I Hudson, Harrison G Pope, J Eric Jensen
Little is known about the acute effects of antidepressant treatments on brain glutamate and gamma-amino-butyric acid (GABA) levels, and their association with clinical response. Using proton magnetic resonance spectroscopy ((1)H-MRS) we examined longitudinally the effects of citalopram on glutamine/glutamate ratios and GABA levels in the pregenual anterior cingulate cortex (pgACC) of individuals with major depressive disorder (MDD). We acquired (1)H-MRS scans at baseline and at days 3, 7, and 42 of citalopram treatment in nineteen unmedicated individuals with MDD...
September 1, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28890853/preferences-for-achromatic-horizontal-vertical-and-square-patterns-in-zebrafish-danio-rerio
#6
Lisa A Rimstad, Adam Holcombe, Alicia Pope, Trevor J Hamilton, Melike P Schalomon
The zebrafish (Danio rerio) is gaining popularity as a laboratory organism and is used to model many human diseases. Many behavioural measures of locomotion and cognition have been developed that involve the processing of visual stimuli. However, the innate preference for vertical and horizontal stripes in zebrafish is unknown. We tested the preference of adult zebrafish for three achromatic patterns (vertical stripes, horizontal stripes, and squares) at three different size conditions (1, 5, and 10 mm). Each animal was tested once in a rectangular arena, which had a different pattern of the same size condition on the walls of either half of the arena...
2017: PeerJ
https://www.readbyqxmd.com/read/28886601/ambient-air-pollution-and-cancer-mortality-in-the-cancer-prevention-study-ii
#7
Michelle C Turner, Daniel Krewski, W Ryan Diver, C Arden Pope, Richard T Burnett, Michael Jerrett, Julian D Marshall, Susan M Gapstur
BACKGROUND: The International Agency for Research on Cancer classified both outdoor air pollution and airborne particulate matter as carcinogenic to humans (Group 1) for lung cancer. There may be associations with cancer at other sites; however, the epidemiological evidence is limited. OBJECTIVE: The aim of this study was to clarify whether ambient air pollution is associated with specific types of cancer other than lung cancer by examining associations of ambient air pollution with nonlung cancer death in the Cancer Prevention Study II (CPS-II)...
August 21, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28876199/self-care-among-healthcare-social-workers-an-exploratory-study
#8
J Jay Miller, Joann Lianekhammy, Natalie Pope, Jacquelyn Lee, Erlene Grise-Owens
Despite growing interest in self-care, few studies have explicitly examined the self-care practices of healthcare social workers. This exploratory study investigated self-care among practitioners (N = 138) in one southeastern state. Overall, data suggest that healthcare social workers only moderately engaged in self-care. Additionally, analyses revealed significant differences in self-care practices by financial stability, overall health, and licensure status, respectively. Interestingly, perceived health status and current financial situation were significant predictors for overall self-care practices...
September 6, 2017: Social Work in Health Care
https://www.readbyqxmd.com/read/28871851/reliability-and-precision-of-the-nana-protocol-to-assess-body-composition-using-dual-energy-x-ray-absorptiometry
#9
Flinn Shiel, Carl Persson, Vini Simas, James Furness, Mike Climstein, Rod Pope, Ben Schram
The Nana positioning protocol is widely used to position participants to minimise technical error when undertaking body composition scanning and analysis with a Dual Energy X-Ray Absorptiometry (DXA) machine. Once biological and technical errors are accounted for, the only variation in test re-test results is from statistical fluctuation or machine error. Therefore, the aim of this study is to assess the test re-test reliability of the Nana positioning protocol, and establish the smallest real difference percentage (SRD%)...
September 5, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/28870986/factors-affecting-seizure-outcome-after-epilepsy-surgery-an-observational-series
#10
Gail S Bell, Jane de Tisi, Juan Carlos Gonzalez-Fraile, Janet L Peacock, Andrew W McEvoy, William F J Harkness, Jacqueline Foong, Rebecca A Pope, Beate Diehl, Josemir W Sander, John S Duncan
IMPORTANCE: Surgical treatment can bring seizure remission in people with focal epilepsy but requires careful selection of candidates. OBJECTIVES: To determine which preoperative factors are associated with postoperative seizure outcome. DESIGN: We audited seizure outcome of 693 adults who had resective epilepsy surgery between 1990 and 2010 and used survival analysis to detect preoperatively identifiable risk factors of poor seizure outcome...
September 4, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28859093/pulling-mscl-open-via-n-terminal-and-tm1-helices-a-computational-study-towards-engineering-an-mscl-nanovalve
#11
Adam D Martinac, Navid Bavi, Omid Bavi, Boris Martinac
There are great opportunities in the manipulation of bacterial mechanosensitive (MS) ion channels for specific and targeted drug delivery purposes. Recent research has shown that these ion channels have the potential to be converted into nanovalves through clever use of magnetic nanoparticles and magnetic fields. Using a combination of molecular dynamics (MD) simulations and the finite element (FE) modelling, this study investigates the theoretical feasibility of opening the MscL channel (MS channel of large conductance of E...
2017: PloS One
https://www.readbyqxmd.com/read/28854855/the-role-of-multiple-internal-timekeepers-and-sources-of-feedback-on-interval-timing
#12
Breanna E Studenka, Daisha L Cummins, Megan A Pope
The aim of the present experiment was to document the role of multiple internal clock mechanisms and external sources of temporal feedback on reducing timing variability when two fingers tap instead of one (a phenomenon known as the bimanual advantage). Previous research documents a reduction in timed interval variability when two effectors time instead of one. In addition, interval variability decreases with multiple sources of feedback. To date, however, no research has explored the separate roles of feedback and internal timing on the bimanual advantage...
August 31, 2017: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/28851767/a-qualitative-study-exploring-the-factors-influencing-admission-to-hospital-from-the-emergency-department
#13
Ian Pope, Helen Burn, Sharif A Ismail, Tim Harris, David McCoy
OBJECTIVE: The number of emergency admissions to hospital in England and Wales has risen sharply in recent years and is a matter of concern to clinicians, policy makers and patients alike. However, the factors that influence this decision are poorly understood. We aimed to ascertain how non-clinical factors can affect hospital admission rates. METHOD: We conducted semistructured interviews with 21 participants from three acute hospital trusts. Participants included 11 emergency department (ED) doctors, 3 ED nurses, 3 managers and 4 inpatient doctors...
August 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/28851676/engaging-adolescents-to-inform-the-development-of-a-mobile-gaming-app-to-incentivize-physical-activity
#14
Lizzy Pope, Bernice Garnett, Marguerite Dibble
BACKGROUND: Involving youth in the development of a mobile game designed to increase physical activity may increase relevancy and adoption. OBJECTIVE: To share the development process used to create a gaming app aimed at incentivizing physical activity in high school students. METHODS: Five focus groups were conducted with high school students (N=50) to understand gaming behaviors. A subset of students from the focus groups chose to complete a Web-based survey (N=10)...
August 29, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28851399/a-mixed-methods-feasibility-and-external-pilot-study-to-inform-a-large-pragmatic-randomised-controlled-trial-of-the-effects-of-surgical-wound-dressing-strategies-on-surgical-site-infections-bluebelle-phase-b-study-protocol-for-a-randomised-controlled-trial
#15
Barnaby C Reeves, Lazaros Andronis, Jane M Blazeby, Natalie S Blencowe, Melanie Calvert, Joanna Coast, Tim Draycott, Jenny L Donovan, Rachael Gooberman-Hill, Robert J Longman, Laura Magill, Jonathan M Mathers, Thomas D Pinkney, Chris A Rogers, Leila Rooshenas, Andrew Torrance, Nicky J Welton, Mark Woodward, Kate Ashton, Katarzyna D Bera, Gemma L Clayton, Lucy A Culliford, Jo C Dumville, Daisy Elliott, Lucy Ellis, Hannah Gould-Brown, Rhiannon C Macefield, Christel McMullan, Caroline Pope, Dimitrios Siassakos, Sean Strong, Helen Talbot
BACKGROUND: Surgical site infections (SSIs) are common, occurring in up to 25% of > 4 million operations performed in England each year. Previous trials of the effect of wound dressings on the risk of developing a SSI are of poor quality and underpowered. METHODS/DESIGN: This study is a feasibility and pilot trial to examine the feasibility of a full trial that will compare simple dressings, no dressing and tissue-glue as a dressing. It is examining the overall acceptability of trial participation, identifying opportunities for refinement, testing the feasibility of and validating new outcome tools to assess SSI, wound management issues and patients' wound symptom experiences...
August 29, 2017: Trials
https://www.readbyqxmd.com/read/28844594/yidc-insertase-of-escherichia-coli-water-accessibility-and-membrane-shaping
#16
Yuanyuan Chen, Sara Capponi, Lu Zhu, Patrick Gellenbeck, J Alfredo Freites, Stephen H White, Ross E Dalbey
The YidC/Oxa1/Alb3 family of membrane proteins function to insert proteins into membranes in bacteria, mitochondria, and chloroplasts. Recent X-ray structures of YidC from Bacillus halodurans and Escherichia coli revealed a hydrophilic groove that is accessible from the lipid bilayer and the cytoplasm. Here, we explore the water accessibility within the conserved core region of the E. coli YidC using in vivo cysteine alkylation scanning and molecular dynamics (MD) simulations of YidC in POPE/POPG membranes...
September 5, 2017: Structure
https://www.readbyqxmd.com/read/28844180/position-and-orientation-of-gallated-proanthocyanidins-in-lipid-bilayer-membranes-influence-of-polymerization-degree-and-linkage-type
#17
Wei Zhu, Ibrahim Khalif, Jinming Peng, Chunmei Li
It is well-known that the biological activity of gallated proanthocyanidins (PAs) is highly structure-dependent. Polymerization degree (DP) and linkage types affect their biological activity greatly. Positions and orientations of gallated PAs in lipid bilayer reveal their structure-function activity at the molecular level. The present work aimed at determining the locations and orientations of epigallocatechin-3-gallate (EGCG) and its derivatives: A-type and B-type EGCG dimers and trimers in 1-palmitoyl-2-oleoyl phosphatidylcholine (POPC) and 1-palmitoyl-2-oleoyl phosphatidylethanolamine (POPE) lipid bilayer via molecular dynamic (MD) simulations...
August 28, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28836730/iron-deficiency-in-heart-failure-efficacy-and-safety-of-intravenous-iron-therapy
#18
Chan-Keat Kang, Michael Pope, Chim C Lang, Paul R Kalra
AIM: To discuss the pathophysiology of iron metabolism in chronic heart failure (CHF), the current knowledge of the efficacy of intravenous (IV) iron therapy in patients with CHF and identify points of controversy as well as highlight areas for future research. DISCUSSION: Iron deficiency is a recognised complication of many chronic conditions. Numerous studies have reported that iron deficiency is highly prevalent in patients with CHF and is associated with exercise intolerance, reduced quality of life, and increased risk of hospitalisation and mortality...
August 24, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28827556/characterization-and-structural-determination-of-a-new-anti-met-function-blocking-antibody-with-binding-epitope-distinct-from-the-ligand-binding-domain
#19
Danielle M DiCara, Dimitri Y Chirgadze, Anthony R Pope, Aneesh Karatt-Vellatt, Anja Winter, Peter Slavny, Joop van den Heuvel, Kothai Parthiban, Jane Holland, Len C Packman, Georgia Mavria, Jens Hoffmann, Walter Birchmeier, Ermanno Gherardi, John McCafferty
The growth and motility factor Hepatocyte Growth Factor/Scatter Factor (HGF/SF) and its receptor, the product of the MET proto-oncogene, promote invasion and metastasis of tumor cells and have been considered potential targets for cancer therapy. We generated a new Met-blocking antibody which binds outside the ligand-binding site, and determined the crystal structure of the Fab in complex with its target, which identifies the binding site as the Met Ig1 domain. The antibody, 107_A07, inhibited HGF/SF-induced cell migration and proliferation in vitro and inhibited growth of tumor xenografts in vivo...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28825688/grip-strength-and-its-relationship-to-police-recruit-task-performance-and-injury-risk-a-retrospective-cohort-study
#20
Robin Orr, Rodney Pope, Michael Stierli, Benjamin Hinton
Suitable grip strength is a police occupational requirement. The aim of this study was to investigate the association between grip strength, task performance and injury risk in a police population. Retrospective data of police recruits (n = 169) who had undergone basic recruit training were provided, including handgrip strength results, occupational task performance measures (consisting of police task simulations [SIM], tactical options [TACOPS] and marksmanship assessments) and injury records. Left hand grip strength (41...
August 21, 2017: International Journal of Environmental Research and Public Health
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