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Mechanochemical ablation

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https://www.readbyqxmd.com/read/29037363/a-systematic-review-and-meta-analysis-of-two-novel-techniques-of-nonthermal-endovenous-ablation-of-the-great-saphenous-vein
#1
REVIEW
Cornelis G Vos, Çağdaş Ünlü, Jan Bosma, Clarissa J van Vlijmen, A Jorianne de Nie, Michiel A Schreve
BACKGROUND: Endothermal treatment of the great saphenous vein (GSV) has become the first-line treatment for superficial venous reflux. Nonthermal ablation has potential benefits for acceptability by patients and decreased risk of nerve injury. We performed a systematic review and meta-analysis to evaluate the efficacy of mechanochemical endovenous ablation (MOCA) and cyanoacrylate vein ablation (CAVA) for GSV incompetence. METHODS: MEDLINE, Embase, Cumulative Index to Nursing and Allied Health Literature, and Cochrane databases were searched for papers published between January 1966 and December 2016...
November 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28971733/reply-to-letter-to-editor-re-mechanochemical-endovenous-ablation-of-saphenous-veins-using-the-clarivein-a-systematic-review-moca-data-reporting-needs-to-be-tighter-and-standardized
#2
Marianne E Witte, Clark J Zeebregts, Gert Jan de Borst, Michel Reijnen, Doeke Boersma
No abstract text is available yet for this article.
January 1, 2017: Phlebology
https://www.readbyqxmd.com/read/28811080/mechanochemical-ablation-for-treatment-of-truncal-venous-insufficiency-a-review-of-the-current-literature
#3
REVIEW
James J Sun, Mohammed M Chowdhury, Umar Sadat, Paul D Hayes, Tjun Y Tang
Mechanochemical ablation (MOCA) is a nonthermal nontumescent technique used in the treatment of superficial venous disease. This review analyzed the available data on the efficacy and safety of MOCA. A systematic literature search was performed. Of 101 studies identified, 14 were suitable for inclusion. The studies were found to be heterogeneous in design, and the quality of evidence was found to be low or very low. MOCA was demonstrated to be effective in the short-term with minimal complications. Consensus guidelines and definitions of reporting outcome measures must be standardized to allow comparison with other techniques...
October 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28764596/letter-to-editor-re-mechanochemical-endovenous-ablation-of-saphenous-veins-using-the-clarivein-a-systematic-review-moca-data-reporting-needs-to-be-tighter-and-standardized
#4
https://www.readbyqxmd.com/read/28411705/mechanochemical-ablation-causes-endothelial-and-medial-damage-to-the-vein-wall-resulting-in-deeper-penetration-of-sclerosant-compared-with-sclerotherapy-alone-in-extrafascial-great-saphenous-vein-using-an-ex%C3%A2-vivo-model
#5
Mark S Whiteley, Scott J Dos Santos, Christopher T Lee, Jian-Mei Li
BACKGROUND: Nonthermal, tumescentless devices are the next generation of minimally invasive devices to treat varicose veins. We aimed to investigate the effects of mechanochemical ablation (MOCA) using ClariVein (Vascular Insights, Quincy, Mass) on ex vivo great saphenous vein with histology and immunofluorescent staining. METHODS: Extrafascial great saphenous veins were harvested during surgery for varicose veins and were treated ex vivo for 10 to 11 minutes with either liquid sclerotherapy or the use of ClariVein, with and without 3% sodium tetradecyl sulfate...
May 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28403687/mechanochemical-endovenous-ablation-of-saphenous-veins-using-the-clarivein-a-systematic-review
#6
Marianne E Witte, Clark J Zeebregts, Gert Jan de Borst, Michel M P J Reijnen, Doeke Boersma
Objective To systematically review all available English literature on mechanochemical endovenous ablation and to report on the anatomical, technical, and clinical success. Methods A systematic literature search was performed in PubMed, EMBASE, and the Cochrane Library on mechanochemical endovenous ablation for the treatment of insufficient great and/or small saphenous vein. Methodological quality of the included studies was evaluated using the MINORS score. The primary outcome measure was anatomical success, defined as closure of the treated vein on follow-up duplex ultrasound imaging...
January 1, 2017: Phlebology
https://www.readbyqxmd.com/read/28065443/commentary-on-macroscopic-and-histological-analysis-of-vessel-wall-reaction-after-mechanochemical-endovenous-ablation-using-the-clarivein-oc-device-in-an-animal-model
#7
M E Vuylsteke
No abstract text is available yet for this article.
January 4, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28025005/macroscopic-and-histologic-analysis-of-vessel-wall-reaction-after-mechanochemical-endovenous-ablation-using-the-clarivein-oc-device-in-an-animal-model
#8
D Boersma, S T W van Haelst, R R J P van Eekeren, A Vink, M M J P Reijnen, J P P M de Vries, G J de Borst
OBJECTIVE/BACKGROUND: Mechanochemical endovenous ablation (MOCA) has been developed as a tumescentless technique to ablate saphenous veins and to avoid heat induced complications and post-procedural pain. The mechanism of action of MOCA is poorly understood. The present experiments were conducted to determine the effect of MOCA on vein wall injury and sclerosis in an animal model. METHODS: A total of 36 lateral saphenous veins (LSVs) were treated in 18 goats according to the human protocol...
February 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/27742900/midterm-outcome-of-mechanochemical-endovenous-ablation-for-the-treatment-of-great-saphenous-vein-insufficiency
#9
Marianne E Witte, Suzanne Holewijn, Ramon R van Eekeren, Jean-Paul de Vries, Clark J Zeebregts, Michel M P J Reijnen
PURPOSE: To report the midterm results of mechanochemical ablation (MOCA) for treating great saphenous vein (GSV) insufficiency. METHODS: In a 1-year period, 85 consecutive patients (median age 51.4 years; 71 women) undergoing MOCA with polidocanol in 104 limbs were enrolled in a prospective registry. The patients were evaluated at baseline and during follow-up (4 weeks and 1, 2, and 3 years) using duplex ultrasound, the CEAP (clinical, etiologic, anatomic and pathophysiologic) classification, the Venous Clinical Severity Score (VCSS), the RAND Short Form 36-Item Health Survey (RAND-SF36), and the Aberdeen Varicose Vein Questionnaire (AVVQ)...
February 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/27552990/endovenous-laser-ablation-versus-mechanochemical-ablation-with-clarivein-%C3%A2-in-the-management-of-superficial-venous-insufficiency-lama-trial-study-protocol-for-a-randomised-controlled-trial
#10
Clement C M Leung, Daniel Carradice, Tom Wallace, Ian C Chetter
BACKGROUND: Endovenous thermal techniques, such as endovenous laser ablation (EVLA), are the recommended treatment for truncal varicose veins. However, a disadvantage of thermal techniques is that it requires the administration of tumescent anaesthesia, which can be uncomfortable. Non-thermal, non-tumescent techniques, such as mechanochemical ablation (MOCA) have potential benefits. MOCA combines physical damage to endothelium using a rotating wire, with the infusion of a liquid sclerosant...
August 24, 2016: Trials
https://www.readbyqxmd.com/read/27511882/comparison-of-microbubble-presence-in-the-right-heart-during-mechanochemical-and-radiofrequency-ablation-for-varicose-veins
#11
K H Moon, B Dharmarajah, R Bootun, C S Lim, Tra Lane, H M Moore, K Sritharan, A H Davies
OBJECTIVE: Mechanochemical ablation is a novel technique for ablation of varicose veins utilising a rotating catheter and liquid sclerosant. Mechanochemical ablation and radiofrequency ablation have no reported neurological side-effect but the rotating mechanism of mechanochemical ablation may produce microbubbles. Air emboli have been implicated as a cause of cerebrovascular events during ultrasound-guided foam sclerotherapy and microbubbles in the heart during ultrasound-guided foam sclerotherapy have been demonstrated...
August 10, 2016: Phlebology
https://www.readbyqxmd.com/read/26908872/phosphorylation-and-calcium-antagonistically-tune-myosin-binding-protein-c-s-structure-and-function
#12
Michael J Previs, Ji Young Mun, Arthur J Michalek, Samantha Beck Previs, James Gulick, Jeffrey Robbins, David M Warshaw, Roger Craig
During each heartbeat, cardiac contractility results from calcium-activated sliding of actin thin filaments toward the centers of myosin thick filaments to shorten cellular length. Cardiac myosin-binding protein C (cMyBP-C) is a component of the thick filament that appears to tune these mechanochemical interactions by its N-terminal domains transiently interacting with actin and/or the myosin S2 domain, sensitizing thin filaments to calcium and governing maximal sliding velocity. Both functional mechanisms are potentially further tunable by phosphorylation of an intrinsically disordered, extensible region of cMyBP-C's N terminus, the M-domain...
March 22, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26908638/clarivein%C3%A2-early-results-from-a-large-single-centre-series-of-mechanochemical-endovenous-ablation-for-varicose-veins
#13
T Y Tang, J W Kam, M E Gaunt
Objectives This study assessed the effectiveness and patient experience of the ClariVein® endovenous occlusion catheter for varicose veins from a large single-centre series in the UK. Methods A total of 300 patients (371 legs) underwent ClariVein® treatment for their varicose veins; 184 for great saphenous vein (GSV) incompetence, 62 bilateral GSV, 23 short saphenous vein (SSV), 6 bilateral SSV and 25 combined unilateral great saphenous vein and SSV. Patients were reviewed at an interval of two months post procedure and underwent Duplex ultrasound assessment...
February 2017: Phlebology
https://www.readbyqxmd.com/read/26811425/mechanochemical-ablation-for-symptomatic-great-saphenous-vein-reflux-a-two-year-follow-up
#14
Pamela S Kim, Muath Bishawi, David Draughn, Marab Boter, Charles Gould, John Koziarski, Rick Bernstein, Richard Hamilton
BACKGROUND: Several studies have shown comparable early efficacy of mechanochemical ablation to endothermal techniques. The goal of this report was to show if early efficacy is maintained at 24 months. METHODS: This was a two-year analysis on the efficacy of mechanochemical ablation in patients with symptomatic C2 or more advanced chronic venous disease. Patients with reflux in the great saphenous vein involving the sapheno-femoral junction and no previous venous interventions were included...
January 24, 2016: Phlebology
https://www.readbyqxmd.com/read/26564912/treatment-modalities-for-small-saphenous-vein-insufficiency-systematic-review-and-meta-analysis
#15
REVIEW
Doeke Boersma, Verena N N Kornmann, Ramon R J P van Eekeren, Ellen Tromp, Çagdas Ünlü, Michel M J P Reijnen, Jean-Paul P M de Vries
PURPOSE: To investigate and compare the anatomical success rates and complications of the treatment modalities for small saphenous vein (SSV) incompetence. METHODS: A systematic literature search was performed in PubMed, EMBASE, and the Cochrane Library on the following therapies for incompetence of SSVs: surgery, endovenous laser ablation (EVLA), radiofrequency ablation (RFA), ultrasound-guided foam sclerotherapy (UGFS), steam ablation, and mechanochemical endovenous ablation (MOCA)...
February 2016: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/26556699/glue-steam-and-clarivein-best-practice-techniques-and-evidence
#16
REVIEW
Mark S Whiteley
In July 2013, the National Institute of Health and Clinical Excellence (NICE) recommended "endothermal" ablation (meaning endovenous thermal ablation) is the first line treatment for truncal venous reflux in varicose veins. The initial endovenous thermoablation devices were radiofrequency ablation and endovenous laser ablation. More recently, Glue (cyanoacrylate), endovenous steam and Clarivein (mechanochemical ablation or MOCA) have entered the market as new endovenous techniques for the treatment of varicose veins...
November 2015: Phlebology
https://www.readbyqxmd.com/read/26307590/clarivein-mechanochemical-ablation-of-the-great-and-small-saphenous-vein-early-treatment-outcomes-of-two-hospitals
#17
MULTICENTER STUDY
Charlotte L Deijen, Michiel A Schreve, Jan Bosma, A Jorianne de Nie, Vanessa J Leijdekkers, Peter J van den Akker, Anco Vahl
OBJECTIVES: Mechanochemical endovenous ablation is a novel technique for the treatment of great saphenous vein and small saphenous vein incompetence which combines mechanical injury of the endothelium with simultaneous infusion of liquid sclerosant. The main objective of this study was to evaluate early occlusion. METHODS: All consecutive patients who were eligible for the treatment with mechanochemical endovenous ablation were included. Inclusion period was from the introduction of the device in the hospitals (September 2011 and December 2011) until December 2012...
April 2016: Phlebology
https://www.readbyqxmd.com/read/26130051/the-advent-of-non-thermal-non-tumescent-techniques-for-treatment-of-varicose-veins
#18
REVIEW
Roshan Bootun, Tristan R A Lane, Alun H Davies
Varicose veins are common and their management has undergone a number of changes over the years. Surgery has been the traditional treatment option, but towards the 21st century, new endovenous thermal ablation techniques, namely, radiofrequency ablation and endovenous laser ablation, were introduced which have revolutionised the way varicose veins are treated. These minimally invasive techniques are associated with earlier return to normal activity and less pain, as well as enabling procedures to be carried out as day cases...
February 2016: Phlebology
https://www.readbyqxmd.com/read/26055013/mechanochemical-endovenous-occlusion-of-varicose-veins-using-the-clarivein%C3%A2-device
#19
REVIEW
Marianne E Witte, Michel M P J Reijnen, Jean-Paul de Vries, Clark J Zeebregts
INTRODUCTION: In the last decade, minimally invasive endothermal ablation techniques have replaced surgery for the treatment of superficial venous insufficiency to reduce postoperative complications and recovery time and to improve quality of life. To avoid the risks of nerve damage and need for tumescent anesthesia to improve patient comfort, an alternative heatless technique has been introduced recently. METHODS: Endovenous mechanochemical occlusion using the ClariVein® catheter (Vascular Insights LLC, Quincy, MA) is a new technique combining mechanical injury to the venous endothelium coupled with simultaneous catheter-guided infusion of a liquid sclerosant...
May 2015: Surgical Technology International
https://www.readbyqxmd.com/read/25723675/retrograde-inversion-stripping-as-a-complication-of-the-clarivein-mechanochemical-venous-ablation-procedure
#20
T R A Lane, H M Moore, I J Franklin, A H Davies
The endovenous revolution has accelerated the development of new techniques and devices for the treatment of varicose veins. The ClariVein mechanochemical ablation device offers tumescentless treatment with a rotating ablation tip that can theoretically become stuck in tissue. We present the first report of retrograde stripping of the small saphenous vein without anaesthesia following attempted use of the ClariVein device, without adverse sequelae.
March 2015: Annals of the Royal College of Surgeons of England
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