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Frank Starling

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https://www.readbyqxmd.com/read/28265101/myosin-filament-activation-in-the-heart-is-tuned-to-the-mechanical-task
#1
Massimo Reconditi, Marco Caremani, Francesca Pinzauti, Joseph D Powers, Theyencheri Narayanan, Ger J M Stienen, Marco Linari, Vincenzo Lombardi, Gabriella Piazzesi
The mammalian heart pumps blood through the vessels, maintaining the dynamic equilibrium in a circulatory system driven by two pumps in series. This vital function is based on the fine-tuning of cardiac performance by the Frank-Starling mechanism that relates the pressure exerted by the contracting ventricle (end systolic pressure) to its volume (end systolic volume). At the level of the sarcomere, the structural unit of the cardiac myocytes, the Frank-Starling mechanism consists of the increase in active force with the increase of sarcomere length (length-dependent activation)...
March 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28236865/does-fasting-influence-preload-responsiveness-in-asa-1-and-2-volunteers
#2
Daniel Rodrigues Alves, Regina Ribeiras
INTRODUCTION: Preoperative fasting was long regarded as an important cause of fluid depletion, leading to hemodynamic instability during surgery should replenishment is not promptly instituted. Lately, this traditional point of view has been progressively challenged, and a growing number of authors now propose a more restrictive approach to fluid management, although doubt remains as to the true hemodynamic influence of preoperative fasting. METHODS: We designed an observational, analytic, prospective, longitudinal study in which 31 ASA 1 and ASA 2 volunteers underwent an echocardiographic examination both before and after a fasting period of at least 6hours (h)...
March 2017: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/28229860/distinct-contributions-of-the-thin-and-thick-filaments-to-length-dependent-activation-in-heart-muscle
#3
Xuemeng Zhang, Thomas Kampourakis, Ziqian Yan, Ivanka Sevrieva, Malcolm Irving, Yin-Biao Sun
The Frank-Starling relation is a fundamental auto-regulatory property of the heart that ensures the volume of blood ejected in each heartbeat is matched to the extent of venous filling. At the cellular level, heart muscle cells generate higher force when stretched, but despite intense efforts the underlying molecular mechanism remains unknown. We applied a fluorescence-based method, which reports structural changes separately in the thick and thin filaments of rat cardiac muscle, to elucidate that mechanism...
February 23, 2017: ELife
https://www.readbyqxmd.com/read/28223172/a-simple-model-of-cardiac-muscle-for-multiscale-simulation-passive-mechanics-crossbridge-kinetics-and-calcium-regulation
#4
Fyodor A Syomin, Andrey K Tsaturyan
A simple model of cardiac muscle was designed for multiscale simulation of heart mechanics. Relaxed cardiac muscle was described as a transversally isotropic hyperelastic material. Active tension caused by actin-myosin crossbridges depends on the ensemble averaged strain of myosin heads bound to actin. Calcium activation was modeled by Ca(2+) binding to troponin-C. To account for the dependence of troponin affinity for Ca(2+) on myosin heads strongly bound to actin, the kinetics of troponin binding to Ca(2+) in the overlap zone of the thin and thick filaments and outside it were separated...
February 20, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28212239/the-frank-starling-curve-is-not-equivalent-to-the-fluid-responsiveness-curve
#5
Ubbo Frank Wiersema, Shailesh Bihari
No abstract text is available yet for this article.
March 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28188931/percutaneous-left-atrial-appendage-closure-improves-left-atrial-mechanical-function-through-frank-starling-mechanism
#6
Augustin Coisne, Rosario Pilato, François Brigadeau, Didier Klug, Christelle Marquie, Zouheir Souissi, Marjorie Richardson, Stéphanie Mouton, Anne-Sophie Polge, Patrizio Lancellotti, Dominique Lacroix, David Montaigne
BACKGROUND: Modifications in left atrial (LA) flow velocities after left atrial appendage (LAA) exclusion have been shown in animal and ex vivo models. In a substudy of PROTECT AF (Percutaneous Closure of the Left Atrial Appendage Versus Warfarin Therapy for Prevention of Stroke in Patients With Atrial Fibrillation), an objective improvement in quality of life was observed after LAA closure. OBJECTIVE: The purpose of this study was to investigate the impact of LAA closure on LA transport function...
February 8, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28140353/basic-cardiovascular-variability-signals-mutual-directed-interactions-explored-in-the-information-domain
#7
Michal Javorka, Jana Krohova, Barbora Czippelova, Zuzana Turianikova, Zuzana Lazarova, Kamil Javorka, Luca Faes
The study of short-term cardiovascular interactions is classically performed through the bivariate analysis of the interactions between the beat-to-beat variability of heart period (RR interval from the ECG) and systolic blood pressure (SBP). Recent progress in the development of multivariate time series analysis methods is making it possible to explore how directed interactions between two signals change in the context of networks including other coupled signals. Exploiting these advances, the present study aims at assessing directional cardiovascular interactions among the basic variability signals of RR, SBP and diastolic blood pressure (DBP), using an approach which allows direct comparison between bivariate and multivariate coupling measures...
January 31, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28098356/mechano-chemo-transduction-in-cardiac-myocytes
#8
Ye Chen-Izu, Leighton T Izu
The heart has the ability to adjust to changing mechanical loads. The Frank-Starling law and the Anrep effect describe exquisite intrinsic mechanisms the heart has for autoregulating the force of contraction to maintain cardiac output under preload and afterload. Although these mechanisms have been known for more than a century, their cellular and molecular underpinnings are still debated. How does the cardiac myocyte sense a change in preload or afterload? How does the myocyte adjust its response to compensate for such changes? In cardiac myocytes Ca(2+) is a crucial regulator of contractile force and in this review we compare and contrast recent results from different labs that address two important questions...
January 18, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28040236/-does-fasting-influence-preload-responsiveness-in-asa-1-and-2-volunteers
#9
Daniel Rodrigues Alves, Regina Ribeiras
INTRODUCTION: Preoperative fasting was long regarded as an important cause of fluid depletion, leading to hemodynamic instability during surgery should replenishment not be promptly instituted. Lately, this traditional point of view has been progressively challenged, and a growing number of authors now propose a more restrictive approach to fluid management, although doubt remains as to the true hemodynamic influence of preoperative fasting. METHODS: We designed an observational, analytic, prospective, longitudinal study in which 31 ASA 1 and ASA 2 volunteers underwent an echocardiographic examination both before and after a fasting period of at least 6h...
March 2017: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/28034373/body-weight-change-during-and-after%C3%A2-hospitalization-for-acute-heart%C3%A2-failure-%C3%A2-patient-characteristics-markers-of-congestion-and-outcomes-findings-from-the-ascend-hf-trial
#10
Andrew P Ambrosy, Lukasz P Cerbin, Paul W Armstrong, Javed Butler, Adrian Coles, Adam D DeVore, Mark E Dunlap, Justin A Ezekowitz, G Michael Felker, Marat Fudim, Stephen J Greene, Adrian F Hernandez, Christopher M O'Connor, Philip Schulte, Randall C Starling, John R Teerlink, Adriaan A Voors, Robert J Mentz
OBJECTIVES: This study sought to examine the relationships between in-hospital and post-discharge body weight changes and outcomes among patients hospitalized for acute heart failure (AHF). BACKGROUND: Body weight changes during and after hospitalization for AHF and the relationships with outcomes have not been well characterized. METHODS: A post hoc analysis was performed of the ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide and Decompensated Heart Failure) trial, which enrolled patients admitted for AHF regardless of ejection fraction...
January 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28017346/body-weight-change-during-and-after%C3%A2-hospitalization-for-acute-heart%C3%A2-failure-%C3%A2-patient-characteristics-markers-of-congestion-and-outcomes-findings-from-ascend-hf
#11
Andrew P Ambrosy, Lukasz P Cerbin, Paul W Armstrong, Javed Butler, Adrian Coles, Adam D DeVore, Mark E Dunlap, Justin A Ezekowitz, G Michael Felker, Marat Fudim, Stephen J Greene, Adrian F Hernandez, Christopher M O'Connor, Philip Schulte, Randall C Starling, John R Teerlink, Adriaan A Voors, Robert J Mentz
OBJECTIVES: This study sought to examine the relationships between in-hospital and post-discharge body weight changes and outcomes among patients hospitalized for acute heart failure (AHF). BACKGROUND: Body weight changes during and after hospitalization for AHF and the relationships with outcomes have not been well characterized. METHODS: A post hoc analysis was performed of the ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide and Decompensated Heart Failure) trial, which enrolled patients admitted for AHF regardless of ejection fraction...
November 30, 2016: JACC. Heart Failure
https://www.readbyqxmd.com/read/27911784/%C3%AE-arrestin-mediates-the-frank-starling-mechanism-of-cardiac-contractility
#12
Dennis M Abraham, Robert T Davis, Chad M Warren, Lan Mao, Beata M Wolska, R John Solaro, Howard A Rockman
The Frank-Starling law of the heart is a physiological phenomenon that describes an intrinsic property of heart muscle in which increased cardiac filling leads to enhanced cardiac contractility. Identified more than a century ago, the Frank-Starling relationship is currently known to involve length-dependent enhancement of cardiac myofilament Ca(2+) sensitivity. However, the upstream molecular events that link cellular stretch to the length-dependent myofilament Ca(2+) sensitivity are poorly understood. Because the angiotensin II type 1 receptor (AT1R) and the multifunctional transducer protein β-arrestin have been shown to mediate mechanosensitive cellular signaling, we tested the hypothesis that these two proteins are involved in the Frank-Starling mechanism of the heart...
December 13, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27865724/leg-lifting-in-hfref-frank-starling-and-mitral-regurgitation
#13
EDITORIAL
Thierry C Gillebert
No abstract text is available yet for this article.
November 10, 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27861429/clinical-implications-of-physiological-flow-adjustment-in-continuous-flow-left-ventricular-assist-devices
#14
Vakhtang Tchantchaleishvili, Jessica G Y Luc, Caitlin M Cohan, Kevin Phan, Laila Hübbert, Steven W Day, H Todd Massey
There is increasing evidence for successful management of end-stage heart failure with continuous-flow left ventricular assist device (CF-LVAD) technology. However, passive flow adjustment at fixed CF-LVAD speed is susceptible to flow balancing issues as well as adverse hemodynamic effects relating to the diminished arterial pulse pressure and flow. With current therapy, flow cannot be adjusted with changes in venous return, which can vary significantly with volume status. This limits the performance and safety of CF-LVAD...
November 15, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27820784/integrating-medical-simulation-into-the-physician-assistant-physiology-curriculum
#15
Lixin Li, John Lopes, Joseph Yi Zhou, Biao Xu
PURPOSE: Medical simulation has recently been used in medical education, and evidence indicates that it is a valuable tool for teaching and evaluation. Very few studies have evaluated the integration of medical simulation in medical physiology education, particularly in PA programs. This study was designed to assess the value of integrating medical simulation into the PA physiology curriculum. METHODS: Seventy-five students from the PA program at Central Michigan University participated in this study...
December 2016: Journal of Physician Assistant Education
https://www.readbyqxmd.com/read/27818308/i-wire-heart-on-a-chip-i-three-dimensional-cardiac-tissue-constructs-for-physiology-and-pharmacology
#16
Veniamin Y Sidorov, Philip C Samson, Tatiana N Sidorova, Jeffrey M Davidson, Chee C Lim, John P Wikswo
Engineered 3D cardiac tissue constructs (ECTCs) can replicate complex cardiac physiology under normal and pathological conditions. Currently, most measurements of ECTC contractility are either made isometrically, with fixed length and without control of the applied force, or auxotonically against a variable force, with the length changing during the contraction. The "I-Wire" platform addresses the unmet need to control the force applied to ECTCs while interrogating their passive and active mechanical and electrical characteristics...
January 15, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/27782102/disulfide-activated-protein-kinase-g-i%C3%AE-regulates-cardiac-diastolic-relaxation-and-fine-tunes-the-frank-starling-response
#17
Jenna Scotcher, Oleksandra Prysyazhna, Andrii Boguslavskyi, Kornel Kistamas, Natasha Hadgraft, Eva D Martin, Jenny Worthington, Olena Rudyk, Pedro Rodriguez Cutillas, Friederike Cuello, Michael J Shattock, Michael S Marber, Maria R Conte, Adam Greenstein, David J Greensmith, Luigi Venetucci, John F Timms, Philip Eaton
The Frank-Starling mechanism allows the amount of blood entering the heart from the veins to be precisely matched with the amount pumped out to the arterial circulation. As the heart fills with blood during diastole, the myocardium is stretched and oxidants are produced. Here we show that protein kinase G Iα (PKGIα) is oxidant-activated during stretch and this form of the kinase selectively phosphorylates cardiac phospholamban Ser16-a site important for diastolic relaxation. We find that hearts of Cys42Ser PKGIα knock-in (KI) mice, which are resistant to PKGIα oxidation, have diastolic dysfunction and a diminished ability to couple ventricular filling with cardiac output on a beat-to-beat basis...
October 26, 2016: Nature Communications
https://www.readbyqxmd.com/read/27752636/cardiac-physiologic-regulation-of-sub-type-specific-adrenergic-receptors-in-transgenic-mice-overexpressing-%C3%AE-1-and-%C3%AE-2-adrenergic-receptors
#18
Ka Eul Kim, Hyun-Jin Tae, Petrashevskaya Natalia, Jae-Chul Lee, Ji Hyeon Ahn, Joon Ha Park, In Hye Kim, Taek Geun Ohk, Chan Woo Park, Jun Hwi Cho, Moo-Ho Won
OBJECTIVE: Combination of β1-adrenergic receptor (AR) blockade and β2-AR activation might be a potential novel therapy for treating heart failure. However, use of β-AR agonists and/or antagonists in the clinical setting is controversial because of the lack of information on cardiac inotropic or chronotropic regulation by AR signaling. METHODS: In this study, we performed hemodynamic evaluation by examining force frequency response (FFR), Frank-Starling relationship, and response to a non-selective β-AR agonist (isoproterenol) in hearts isolated from 6-month-old transgenic (TG) mice overexpressing β1- and β2-ARs (β1- and β2-AR TG mice, respectively)...
September 2016: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/27744404/epidermal-growth-factor-receptor-silencing-blunts-the-slow-force-response-to-myocardial-stretch
#19
María S Brea, Romina G Díaz, Daiana S Escudero, Claudia I Caldiz, Enrique L Portiansky, Patricio E Morgan, Néstor G Pérez
BACKGROUND: Myocardial stretch increases force biphasically: the Frank-Starling mechanism followed by the slow force response (SFR). Based on pharmacological strategies, we proposed that epidermal growth factor (EGF) receptor (EGFR or ErbB1) activation is crucial for SFR development. Pharmacological inhibitors could block ErbB4, a member of the ErbB family present in the adult heart. We aimed to specifically test the role of EGFR activation after stretch, with an interference RNA incorporated into a lentiviral vector (small hairpin RNA [shRNA]-EGFR)...
October 15, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27737958/mechanical-stress-conditioning-and-electrical-stimulation-promote-contractility-and-force-maturation-of-induced-pluripotent-stem-cell-derived-human-cardiac-tissue
#20
Jia-Ling Ruan, Nathaniel L Tulloch, Maria V Razumova, Mark Saiget, Veronica Muskheli, Lil Pabon, Hans Reinecke, Michael Regnier, Charles E Murry
BACKGROUND: Tissue engineering enables the generation of functional human cardiac tissue with cells derived in vitro in combination with biocompatible materials. Human-induced pluripotent stem cell-derived cardiomyocytes provide a cell source for cardiac tissue engineering; however, their immaturity limits their potential applications. Here we sought to study the effect of mechanical conditioning and electric pacing on the maturation of human-induced pluripotent stem cell-derived cardiac tissues...
November 15, 2016: Circulation
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