Léa Décarie-Spain, Cindy Gu, Logan Tierno Lauer, Keshav S Subramanian, Samar N Chehimi, Alicia E Kao, Iris Deng, Alexander G Bashaw, Molly E Klug, Ashyah Hewage Galbokke, Kristen N Donohue, Mingxin Yang, Guillaume de Lartigue, Kevin P Myers, Richard C Crist, Benjamin C Reiner, Matthew R Hayes, Scott E Kanoski
The ability to encode and retrieve meal-related information is critical to efficiently guide energy acquisition and consumption, yet the underlying neural processes remain elusive. Here we reveal that ventral hippocampus (HPCv) neuronal activity dynamically elevates during meal consumption and this response is highly predictive of subsequent performance in a foraging-related spatial memory task. Targeted recombination-mediated ablation of HPCv meal-responsive neurons impairs foraging-related spatial memory without influencing food motivation, anxiety-like behavior, or escape-mediated spatial memory...
October 10, 2023: bioRxiv