keyword
MENU ▼
Read by QxMD icon Read
search

chitin wound healing

keyword
https://www.readbyqxmd.com/read/29339554/synthetic-biology-strategies-for-improving-microbial-synthesis-of-green-biopolymers
#1
Lisa A Anderson, M Ahsanul Islam, Kristala L J Prather
Polysaccharide-based biopolymers have many material properties relevant to industrial and medical uses, including as drug delivery agents, wound healing adhesives, and food additives and stabilizers. Traditionally, polysaccharides are obtained from natural sources. Microbial synthesis offers an attractive alternative for sustainable production of tailored biopolymers. Here, we review synthetic biology strategies for select "green" biopolymers: cellulose, alginate, chitin, chitosan, and hyaluronan. Microbial production pathways, opportunities for pathway yield improvements, and advances in microbial engineering of biopolymers in various hosts are discussed...
January 16, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29248555/a-review-on-chitosan-and-its-nanocomposites-in-drug-delivery
#2
REVIEW
Akbar Ali, Shakeel Ahmed
Chitosan the second most abundant next to cellulose, naturally occurring amino polysaccharide, derived as a deacetylated form of chitin. Its nontoxic, biocompatible, antibacterial and biodegradable properties have led to significant research towards biomedical and pharmaceutical applications, such as drug delivery, tissue engineering, wound-healing dressing etc. The primary amine group in chitosan are responsible for its various properties such as cationic nature, controlled drug release, muco-adhesion, in situ gelation, antimicrobial, permeation enhancement etc...
December 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29126937/coccinia-indica-agglutinin-a-17kda-pp2-like-phloem-lectin-affinity-purification-primary-structure-and-formation-of-self-assembled-filaments
#3
Kishore Babu Bobbili, Gottfried Pohlentz, Akkaladevi Narahari, Kaushal Sharma, A Surolia, Michael Mormann, Musti J Swamy
Phloem protein-2 (PP2) is an abundant soluble protein in the sieve elements in plants. Its lectin property was reported in various species. The primary structure of PP2 from Coccinia indica (Coccinia indica agglutinin, CIA17), determined by mass spectrometry, shows extensive homology with PP2 super family phloem lectins. Analysis of mass spectrometric data indicated the presence of 16 potential allelic variants of CIA17 with insignificant divergence in the primary structure. The primary structure contains an intramolecular disulfide bridge between Cys-34 and Cys-51, which is conserved across various cucurbit species and hence likely to be important for carbohydrate binding...
November 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29103510/regenerated-chitin-fibers-reinforced-with-bacterial-cellulose-nanocrystals-as-suture-biomaterials
#4
Huanling Wu, Gareth R Williams, Junzi Wu, Jianrong Wu, Shiwei Niu, Heyu Li, Haijun Wang, Limin Zhu
The objective of this work was to prepare a novel filament with good biocompatibility and mechanical performance which can meet the demands of surgical sutures. Bacterial cellulose nanocrystals (BCNCs) were used to reinforce regenerated chitin (RC) fibers to form BCNC/RC filaments. Mechanical performance measurements demonstrated that the strength of the BCNC/RC filament was increased dramatically over the RC analogue. A yarn made of 30 BCNC-loaded fibers also achieved satisfactory mechanical performance, with a knot-pull tensile strength of 9...
January 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28866015/chitosan-as-biomaterial-in-drug-delivery-and-tissue-engineering
#5
REVIEW
Saad M Ahsan, Mathai Thomas, Kranthi K Reddy, Sujata Gopal Sooraparaju, Amit Asthana, Ira Bhatnagar
Chitin is one of the most abundant polysaccharide found on earth. The deacetylated form of chitin viz. chitosan has been reported for its various important pharmacological properties and its role in tissue engineering and regenerative medicine is also well documented. Chitosan based bone graft substitutes are biocompatible, biodegradable, osteoconductive, osteoinductive and structurally similar to bone, with excellent mechanical strength and cost effectiveness. Chitosan based hydrogels and wound healing bandages have also found a great market in the field of medicine...
August 30, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28821125/a-chitin-film-containing-basic-fibroblast-growth-factor-with-a-chitin-binding-domain-as-wound-dressings
#6
Yu Wang, Chuan Fu, Zhenxu Wu, Li Chen, Xuesi Chen, Yen Wei, Peibiao Zhang
Basic fibroblast growth factor (bFGF) can stimulate wound healing. However, consistent delivery of bFGF has many disadvantages. To decrease their instability and diffusible, we introduced chitin-binding domain (ChtBD) into bFGF. Two expression plasimids were constructed. The first one (named bFGF) contained bFGF (154 amino acids), the second (named ChtBD-bFGF) contained bFGF and the ChtBD (54 amino acids). ChtBD was derived from chitinase A1 (ChiA1) of Bacillus circulans WL-12. The recombinant protein ChtBD-bFGF had the same biological activity as bFGF in promoting fibroblast proliferation...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28799228/chitin-and-chitosan-biopolymers-for-wound-management
#7
Rita Singh, Kirti Shitiz, Antaryami Singh
Chitin and chitosan are biopolymers with excellent bioactive properties, such as biodegradability, non-toxicity, biocompatibility, haemostatic activity and antimicrobial activity. A wide variety of biomedical applications for chitin and chitin derivatives have been reported, including wound-healing applications. They are reported to promote rapid dermal regeneration and accelerate wound healing. A number of dressing materials based on chitin and chitosan have been developed for the treatment of wounds. Chitin and chitosan with beneficial intrinsic properties and high potential for wound healing are attractive biopolymers for wound management...
August 10, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28415488/ultrasound-stimulated-release-of-gallic-acid-from-chitin-hydrogel-matrix
#8
Huixin Jiang, Takaomi Kobayashi
Ultrasound (US) stimulated drug release was examined in this study using a chitin hydrogel matrix loaded with gallic acid (GA), a drug used for wound healing and anticancer. Using phase inversion, GA-chitin hydrogels were prepared from chitin-dimethylacetamide (DMAc)/lithium chloride (LiCl) solution in the presence of GA, with 24h exposure of the solution to water vapor. The GA release from the GA-chitin hydrogel was examined under different US powers of 0-30W at 43kHz. The effects of GA loading amounts in the hydrogels (0...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28361239/implications-of-molecular-diversity-of-chitin-and-its-derivatives
#9
REVIEW
Faez Iqbal Khan, Safikur Rahman, Aarfa Queen, Shahzaib Ahamad, Sher Ali, Jihoe Kim, Md Imtaiyaz Hassan
Chitin is a long unbranched polysaccharide, made up of β-1,4-linked N-acetylglucosamine which forms crystalline fiber-like structure. It is present in the fungal cell walls, insect and crustacean cuticles, nematode eggshells, and protozoa cyst. We provide a critical appraisal on the chemical modifications of chitin and its derivatives in the context of their improved efficacy in medical applications without any side effect. Recent advancement in nanobiotechnology has helped to synthesize several chitin derivatives having significant biological applications...
May 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28349375/evaluation-of-chitosan-based-films-containing-gelatin-chondroitin-4-sulfate-and-zno-for-wound-healing
#10
Thiago B Cahú, Rodrigo A Silva, Raquel P F Silva, Milena M Silva, Isabel R S Arruda, Janilson F Silva, Romero M P B Costa, Suzan D Santos, Helena B Nader, Ranilson S Bezerra
In this work, chitosan-based films containing gelatin and chondroitin-4-sulfate (C4S) with and without ZnO particles were produced and tested in vitro to investigate their potential wound healing properties. Chitosans were produced from shrimp-head processing waste by alkaline deacetylation of chitin to obtain chitosans differing in molecular weight and degree of deacetylation (80 ± 0.5%). The film-forming solutions (chitosan, C4S and gelatin) and ZnO suspension showed no toxicity towards fibroblasts or keratinocytes...
March 27, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28335317/cytotoxicity-of-silver-nanoparticle-and-chitin-nanofiber-sheet-composites-caused-by-oxidative-stress
#11
Jun Kinoda, Masayuki Ishihara, Hidemi Hattori, Shingo Nakamura, Koichi Fukuda, Hidetaka Yokoe
Size-controlled spherical silver nanoparticles (<10 nm) and chitin-nanofiber sheet composites (Ag NPs/CNFS) have previously been reported to have strong antimicrobial activity in vitro. Although Ag NPs/CNFS have strong antimicrobial activity, their cytotoxicity has not been investigated. This study was performed to evaluate the effects of Ag NPs/CNFS on cytotoxicity for fibroblasts in vitro and healing delay of wound repair in vivo, focused on oxidative stress. Cytotoxic activities of Ag NPs/CNFS were investigated using a fibroblast cell proliferation assay, nitric oxide/nitrogen dioxide (NO/NO₂) measurement of the cell lysates in vitro, inhibitory effects of Ag NPs/CNFS on healing-impaired wound repair using diabetic mice in vivo, 8-hydroxy-2'-deoxyguanosine (8-OHdG) immunohistochemical staining of the skin sections, and generation of carbonyl protein in the wound was performed to evaluate cytotoxicity with oxidative stress...
October 20, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28327272/effects-of-electrospun-scaffolds-of-di-o-butyrylchitin-and-poly-%C3%AE%C2%B5-caprolactone-on-wound-healing
#12
Jacek Drobnik, Izabella Krucinska, Agnieszka Komisarczyk, Stanislaw Sporny, Alicja Szczepanowska, Joanna Ciosek
BACKGROUND: We sought to determine the usefulness of electrospun dibutyrylchitin (DBC) or poly-(ε-caprolactone [PCL]), in wound treatment. We investigated the mechanisms of action of these polymers on wound healing. METHODS: We synthesized DBC, a newly identified ester derivative of chitin, using a patented method comprising the substitution of butyryl groups at positions C-3 and C-6 in chitin molecules. We confirmed the double substitution by the butyric groups using infrared spectrometry...
June 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/28079980/induction-of-mesenchymal-stem-cell-differentiation-in-the-absence-of-soluble-inducer-for-cutaneous-wound-regeneration-by-a-chitin-nanofiber-based-hydrogel
#13
Kangquan Shou, Yao Huang, Baiwen Qi, Xiang Hu, Zhanjun Ma, Ang Lu, Chao Jian, Lina Zhang, Aixi Yu
Transplantation of bone marrow mesenchymal stem cells (BMSCs) has been considered to be a promising strategy for wound healing. However, poor viability of engrafted BMSCs and limited capabilities of differentiation into the desired cell types in wounds often hinder its application. Few studies report the induction of BMSC differentiation into the skin regeneration-related cell types using natural biopolymer, e.g. chitin and its derivative. Here we utilized a chitin nanofiber (CNF) hydrogel as a directive cue to induce BMSC differentiation for enhancing cutaneous wound regeneration in the absence of cell-differentiating factors...
January 12, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28062236/enhanced-wound-healing-activity-of-desert-locust-schistocerca-gregaria-vs-shrimp-penaeus-monodon-chitosan-based-scaffolds
#14
COMPARATIVE STUDY
Narguess H Marei, W El-Mazny, Aida El-Shaer, Kareem Dorri Zaki, Zahra S Hussein, Emtithal M Abd-El-Samie
Chitosan (CS) has received great attention in tissue engineering, especially in wound healing acceleration. In this study, chitin was isolated from desert locust (Schistocerca gregaria) and shrimp (Penaeus monodon) then deacetylated to chitosan. Then, chitosan was characterized by degree of deacetylation (DD), molecular weight (M.Wt), swelling index (SI), Fourier transform infrared (FTIR) and X ray diffraction (XRD). The chitosan was then casted into 2D scaffolds and was pictured using scanning electron microscope (SEM)...
April 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27494238/advances-and-potential-applications-of-chitosan-nanoparticles-as-a-delivery-carrier-in-the-vaccine
#15
Kai Zhao, Dan Li, Hong Kang, Yu Guang Rong, Xiaohua Wang, Zheng Jin
Chitosan, a natural polysaccharide derived from chitin, has been widely applied in drug delivery, tissue regeneration, wound healing, blood coagulation and immunostimulation due to its well-known biocompatibility and biodegradability. Chitosan has become a valuable vaccine adjuvant and delivery carrier, which have attracted increasing attention for its applications. Currently chitosan nanoparticles have been developed as adjuvant or immunomodulators and drug carrier. Here we reviewed chitosan nanoparticles, which is a promising biomaterial as vaccine adjuvant and delivery carrier, including characteristics, preparation methods and applications, or even its limitations...
August 4, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27494157/advances-and-potential-applications-of-chitosan-nanoparticles-as-a-delivery-carrier-for-the-mucosal-immunity-of-vaccine
#16
REVIEW
Dan Li, Dongwei Fu, Hong Kang, Guangyu Rong, Zheng Jin, Xiaohua Wang, Kai Zhao
BACKGROUND: Drug research and development has entered into the new epoch of innovation formulation, and the drug delivery system has been in the forefront of pharmaceutical innovation. Chitosan, a natural polysaccharide derived from chitin, due to its well-known biocompatibility and biodegradability, it has been widely used in drug delivery, immunostimulation, tissue regeneration, blood coagulation, wound healing, drug delivery and tissue engineering. Chitosan has become a valuable vaccine adjuvant and delivery carrier, which have attracted increasing attention for its applications...
2017: Current Drug Delivery
https://www.readbyqxmd.com/read/27294905/fabrication-characterization-and-evaluation-of-bionanocomposites-based-on-natural-polymers-and-antibiotics-for-wound-healing-applications
#17
Marius Rădulescu, Alina Maria Holban, Laurențiu Mogoantă, Tudor-Adrian Bălşeanu, George Dan Mogoșanu, Diana Savu, Roxana Cristina Popescu, Oana Fufă, Alexandru Mihai Grumezescu, Eugenia Bezirtzoglou, Veronica Lazar, Mariana Carmen Chifiriuc
The aim of our research activity was to obtain a biocompatible nanostructured composite based on naturally derived biopolymers (chitin and sodium alginate) loaded with commercial antibiotics (either Cefuroxime or Cefepime) with dual functions, namely promoting wound healing and assuring the local delivery of the loaded antibiotic. Compositional, structural, and morphological evaluations were performed by using the thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and fourier transform infrared spectroscopy (FTIR) analytical techniques...
June 10, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27265311/novel-chitin-chitosan-glucan-wound-dressing-isolation-characterization-antibacterial-activity-and-wound-healing-properties
#18
A M Abdel-Mohsen, J Jancar, D Massoud, Z Fohlerova, H Elhadidy, Z Spotz, A Hebeish
Chitin/chitosan-glucan complex (ChCsGC) was isolated from Schizophyllum commune (S. commune) and dissolved for the first time in precooled (-15°C) 8wt.% urea/6wt.% NaOH aqueous solution. Novel nonwoven microfiber mats were fabricated by wet-dry-spinning technique and evaluated the mechanical of fabrics mats and surface morphology. Isolated and nonwoven mat were characterized employing FTIR-ATR, Optical microscope, TGA, DSC, H/C NMR, SEM and XRD techniques. According to the physical/chemical characterization measurements we can assumed that, the net and the novel dressing mats have the same chemical structure with slightly changes in the thermal stability for the dressing mats...
August 20, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27015974/development-of-the-intein-mediated-method-for-production-of-recombinant-thymosin-%C3%AE-4-from-the-acetylated-in-vivo-fusion-protein
#19
Roman S Esipov, Dmitry A Makarov, Vasily N Stepanenko, Anatoly I Miroshnikov
Thymosin β4 is a 43 amino acid long peptide with an acetylated N-terminal serin that has a high potential as a remedy for healing ulcers, wounds and burns. Although protein biosynthesis offers attractive opportunities in terms of a large-scale production, currently thymosin β4 is mainly produced by chemical synthesis. The problems that hinder the successful commercialization of the biotechnological approach are associated with the small peptides expression and N-terminal acetylation. This work presents an innovative biotechnological method for thymosin β4 production that employs the peptide acetylation in vivo...
June 20, 2016: Journal of Biotechnology
https://www.readbyqxmd.com/read/26959621/effects-of-chitin-and-sepia-ink-hybrid-sponge-on-the-healing-of-burning-wound-rats-and-its-impact-on-macrophages-in-vitro
#20
Wei Zhang, Yan Wang, Xianxian Sui, Yulin Sun, Daohai Chen
PURPOSE: To detect whether chitin and sepia ink sponge (CS) can promote wound healing and elevate impact of CS on phagocytosis ability of macrophages. METHODS: Forty-eight rats were assigned to four groups: Normal group (Normal), negative control group (Con), chitin and sepia ink sponge group (CS) and positive control Surgicel Gauze(r) group (SG). Deep second-degree burn model was created in rats. Wound area was recorded by digital imaging and determined using Image J software...
February 2016: Acta Cirúrgica Brasileira
keyword
keyword
115286
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"