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chitin wound healing

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https://www.readbyqxmd.com/read/29773374/electrospinning-and-wound-healing-activity-of-%C3%AE-chitin-extracted-from-cuttlefish-bone
#1
Hyeong-Seop Jung, Min Hee Kim, Ji Youn Shin, Se Ra Park, Ju-Young Jung, Won Ho Park
A nanofibrous β-chitin web was fabricated via electrospinning for use as a novel wound dressing material. β-chitin was extracted from cuttlefish bone using deproteinization and demineralization. First, cuttlefish bone was alkali-treated to remove the proteins and was then treated with the acid for demineralization. The extracted β-chitin was dissolved in formic acid as solvent to evaluate its electrospinnability, and the electrospinnability increased remarkably when β-chitin was blended with poly(ethylene oxide) (PEO) than without...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29744543/advances-in-processing-chitin-as-a-promising-biomaterial-from-ionic-liquids
#2
Julia L Shamshina, Oleksandra Zavgorodnya, Robin D Rogers
Chitin isolated through microwave-assisted dissolution using ionic liquids is a high molecular weight (MW) polymer that can be manufactured into materials of different architectures (e.g., fibers, films, microspheres, nanostructured materials) to be used as wound care dressings, drug delivery devices, scaffolds, etc. However, because of differences from traditional isolation methods and, thus, differences in polymer length and degree of deacetylation, it could exhibit bio-related properties that differ from those of traditionally 'pulped' chitin...
May 10, 2018: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/29581004/preparation-of-biocompatible-and-biodegradable-silk-fibroin-chitin-silver-nanoparticles-3d-scaffolds-as-a-bandage-for-antimicrobial-wound-dressing
#3
Mojtaba Ghanbari Mehrabani, Ramin Karimian, Bahareh Mehramouz, Mahdi Rahimi, Hossein Samadi Kafil
One of the most serious challenge in wound care is difficulty of the infection control in wound healing process. Wound dressings with antimicrobial effects are useful to minimize the bacterial infections of wounds. In this study a biocompatible and biodegradable silk fibroin/chitin nanocomposite scaffolds with various content of silver nanoparticles (0.001, 0.01, and 0.1%) were fabricated via freeze-drying method for successful wound dressing application. The nanocomposite scaffolds have biocompatibility with high antimicrobial effects, good mechanical properties, and high porosity...
March 23, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29580422/wound-dressings-from-naturally-occurring-polymers-a-review-on-homopolysaccharide-based-composites
#4
REVIEW
Mahdi Naseri-Nosar, Zyta Maria Ziora
Wound dressings are designed to support the wound bed and protect it from the factors that may delay or impede its healing such as contaminations and moisture-loss, thereby facilitating and accelerating the healing process. The materials used to prepare wound dressings include natural and synthetic polymers, as well as their combinations, in the forms of films, sponges and hydrogels. Polysaccharides are naturally-occurring polymers that have been extensively used as wound dressing materials. Homopolysaccharides are a class of polysaccharides consist of only one type of monosaccharide...
June 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29453888/dual-transcriptomics-reveals-co-evolutionary-mechanisms-of-intestinal-parasite-infections-in-blue-mussels-mytilus-edulis
#5
Marieke E Feis, Uwe John, Ana Lokmer, Pieternella C Luttikhuizen, K Mathias Wegner
On theoretical grounds, antagonistic co-evolution between hosts and their parasites should be a widespread phenomenon but only received little empirical support so far. Consequently, the underlying molecular mechanisms and evolutionary steps remain elusive, especially in nonmodel systems. Here, we utilized the natural history of invasive parasites to document the molecular underpinnings of co-evolutionary trajectories. We applied a dual-species transcriptomics approach to experimental cross-infections of blue mussel Mytilus edulis hosts and their invasive parasitic copepods Mytilicola intestinalis from two invasion fronts in the Wadden Sea...
March 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29448839/role-of-growth-factors-and-biomaterials-in-wound-healing
#6
Farshad Zarei, Maryam Soleimaninejad
Wound healing is a biological complex process that involves several cell types under the control and regulation of several growth factors and cytokines. There have been efforts to study the therapeutic effects of granulocyte-macrophage colony-stimulating factor, platelet-derived growth factor, transforming growth factor-β, vascular endothelial growth factor and basic fibroblast growth factor on chronic wounds. In addition, the effects of biomaterials such as nano-fibrous chitin and chitosan have been proven to be effective on wound healing...
February 15, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29339554/synthetic-biology-strategies-for-improving-microbial-synthesis-of-green-biopolymers
#7
REVIEW
Lisa A Anderson, M Ahsanul Islam, Kristala L J Prather
Polysaccharide-based biopolymers have many material properties relevant to industrial and medical uses, including as drug delivery agents, wound-healing adhesives, and food additives and stabilizers. Traditionally, polysaccharides are obtained from natural sources. Microbial synthesis offers an attractive alternative for sustainable production of tailored biopolymers. Here, we review synthetic biology strategies for select "green" biopolymers: cellulose, alginate, chitin, chitosan, and hyaluronan...
April 6, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29248555/a-review-on-chitosan-and-its-nanocomposites-in-drug-delivery
#8
REVIEW
Akbar Ali, Shakeel Ahmed
Chitosan the second most abundant next to cellulose, naturally occurring amino polysaccharide, derived as a deacetylated form of chitin. Its nontoxic, biocompatible, antibacterial and biodegradable properties have led to significant research towards biomedical and pharmaceutical applications, such as drug delivery, tissue engineering, wound-healing dressing etc. The primary amine group in chitosan are responsible for its various properties such as cationic nature, controlled drug release, muco-adhesion, in situ gelation, antimicrobial, permeation enhancement etc...
April 1, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29126937/coccinia-indica-agglutinin-a-17kda-pp2-like-phloem-lectin-affinity-purification-primary-structure-and-formation-of-self-assembled-filaments
#9
Kishore Babu Bobbili, Gottfried Pohlentz, Akkaladevi Narahari, Kaushal Sharma, Avadhesha Surolia, Michael Mormann, Musti J Swamy
Phloem protein-2 (PP2) is an abundant soluble protein in the sieve elements in plants. Its lectin property was reported in various species. The primary structure of a 17kDa PP2 from Coccinia indica (Coccinia indica agglutinin, CIA17), determined by mass spectrometry, shows extensive homology with PP2 super family phloem lectins. Analysis of mass spectrometric data indicated the presence of 16 potential allelic variants of CIA17 with insignificant divergence in the primary structure. The primary structure contains an intramolecular disulfide bridge between Cys-34 and Cys-51, which is conserved across various cucurbit species and hence likely to be important for carbohydrate binding...
March 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29103510/regenerated-chitin-fibers-reinforced-with-bacterial-cellulose-nanocrystals-as-suture-biomaterials
#10
Huanling Wu, Gareth R Williams, Junzi Wu, Jianrong Wu, Shiwei Niu, Heyu Li, Haijun Wang, Limin Zhu
The objective of this work was to prepare a novel filament with good biocompatibility and mechanical performance which can meet the demands of surgical sutures. Bacterial cellulose nanocrystals (BCNCs) were used to reinforce regenerated chitin (RC) fibers to form BCNC/RC filaments. Mechanical performance measurements demonstrated that the strength of the BCNC/RC filament was increased dramatically over the RC analogue. A yarn made of 30 BCNC-loaded fibers also achieved satisfactory mechanical performance, with a knot-pull tensile strength of 9...
January 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28866015/chitosan-as-biomaterial-in-drug-delivery-and-tissue-engineering
#11
REVIEW
Saad M Ahsan, Mathai Thomas, Kranthi K Reddy, Sujata Gopal Sooraparaju, Amit Asthana, Ira Bhatnagar
Chitin is one of the most abundant polysaccharide found on earth. The deacetylated form of chitin viz. chitosan has been reported for its various important pharmacological properties and its role in tissue engineering and regenerative medicine is also well documented. Chitosan based bone graft substitutes are biocompatible, biodegradable, osteoconductive, osteoinductive and structurally similar to bone, with excellent mechanical strength and cost effectiveness. Chitosan based hydrogels and wound healing bandages have also found a great market in the field of medicine...
April 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28821125/a-chitin-film-containing-basic-fibroblast-growth-factor-with-a-chitin-binding-domain-as-wound-dressings
#12
Yu Wang, Chuan Fu, Zhenxu Wu, Li Chen, Xuesi Chen, Yen Wei, Peibiao Zhang
Basic fibroblast growth factor (bFGF) can stimulate wound healing. However, consistent delivery of bFGF has many disadvantages. To decrease their instability and diffusible, we introduced chitin-binding domain (ChtBD) into bFGF. Two expression plasimids were constructed. The first one (named bFGF) contained bFGF (154 amino acids), the second (named ChtBD-bFGF) contained bFGF and the ChtBD (54 amino acids). ChtBD was derived from chitinase A1 (ChiA1) of Bacillus circulans WL-12. The recombinant protein ChtBD-bFGF had the same biological activity as bFGF in promoting fibroblast proliferation...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28799228/chitin-and-chitosan-biopolymers-for-wound-management
#13
Rita Singh, Kirti Shitiz, Antaryami Singh
Chitin and chitosan are biopolymers with excellent bioactive properties, such as biodegradability, non-toxicity, biocompatibility, haemostatic activity and antimicrobial activity. A wide variety of biomedical applications for chitin and chitin derivatives have been reported, including wound-healing applications. They are reported to promote rapid dermal regeneration and accelerate wound healing. A number of dressing materials based on chitin and chitosan have been developed for the treatment of wounds. Chitin and chitosan with beneficial intrinsic properties and high potential for wound healing are attractive biopolymers for wound management...
December 2017: International Wound Journal
https://www.readbyqxmd.com/read/28415488/ultrasound-stimulated-release-of-gallic-acid-from-chitin-hydrogel-matrix
#14
Huixin Jiang, Takaomi Kobayashi
Ultrasound (US) stimulated drug release was examined in this study using a chitin hydrogel matrix loaded with gallic acid (GA), a drug used for wound healing and anticancer. Using phase inversion, GA-chitin hydrogels were prepared from chitin-dimethylacetamide (DMAc)/lithium chloride (LiCl) solution in the presence of GA, with 24h exposure of the solution to water vapor. The GA release from the GA-chitin hydrogel was examined under different US powers of 0-30W at 43kHz. The effects of GA loading amounts in the hydrogels (0...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28361239/implications-of-molecular-diversity-of-chitin-and-its-derivatives
#15
REVIEW
Faez Iqbal Khan, Safikur Rahman, Aarfa Queen, Shahzaib Ahamad, Sher Ali, Jihoe Kim, Md Imtaiyaz Hassan
Chitin is a long unbranched polysaccharide, made up of β-1,4-linked N-acetylglucosamine which forms crystalline fiber-like structure. It is present in the fungal cell walls, insect and crustacean cuticles, nematode eggshells, and protozoa cyst. We provide a critical appraisal on the chemical modifications of chitin and its derivatives in the context of their improved efficacy in medical applications without any side effect. Recent advancement in nanobiotechnology has helped to synthesize several chitin derivatives having significant biological applications...
May 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28349375/evaluation-of-chitosan-based-films-containing-gelatin-chondroitin-4-sulfate-and-zno-for-wound-healing
#16
Thiago B Cahú, Rodrigo A Silva, Raquel P F Silva, Milena M Silva, Isabel R S Arruda, Janilson F Silva, Romero M P B Costa, Suzan D Santos, Helena B Nader, Ranilson S Bezerra
In this work, chitosan-based films containing gelatin and chondroitin-4-sulfate (C4S) with and without ZnO particles were produced and tested in vitro to investigate their potential wound healing properties. Chitosans were produced from shrimp-head processing waste by alkaline deacetylation of chitin to obtain chitosans differing in molecular weight and degree of deacetylation (80 ± 0.5%). The film-forming solutions (chitosan, C4S and gelatin) and ZnO suspension showed no toxicity towards fibroblasts or keratinocytes...
November 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28335317/cytotoxicity-of-silver-nanoparticle-and-chitin-nanofiber-sheet-composites-caused-by-oxidative-stress
#17
Jun Kinoda, Masayuki Ishihara, Hidemi Hattori, Shingo Nakamura, Koichi Fukuda, Hidetaka Yokoe
Size-controlled spherical silver nanoparticles (<10 nm) and chitin-nanofiber sheet composites (Ag NPs/CNFS) have previously been reported to have strong antimicrobial activity in vitro. Although Ag NPs/CNFS have strong antimicrobial activity, their cytotoxicity has not been investigated. This study was performed to evaluate the effects of Ag NPs/CNFS on cytotoxicity for fibroblasts in vitro and healing delay of wound repair in vivo, focused on oxidative stress. Cytotoxic activities of Ag NPs/CNFS were investigated using a fibroblast cell proliferation assay, nitric oxide/nitrogen dioxide (NO/NO₂) measurement of the cell lysates in vitro, inhibitory effects of Ag NPs/CNFS on healing-impaired wound repair using diabetic mice in vivo, 8-hydroxy-2'-deoxyguanosine (8-OHdG) immunohistochemical staining of the skin sections, and generation of carbonyl protein in the wound was performed to evaluate cytotoxicity with oxidative stress...
October 20, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28327272/effects-of-electrospun-scaffolds-of-di-o-butyrylchitin-and-poly-%C3%AE%C2%B5-caprolactone-on-wound-healing
#18
Jacek Drobnik, Izabella Krucinska, Agnieszka Komisarczyk, Stanislaw Sporny, Alicja Szczepanowska, Joanna Ciosek
BACKGROUND: We sought to determine the usefulness of electrospun dibutyrylchitin (DBC) or poly-(ε-caprolactone [PCL]), in wound treatment. We investigated the mechanisms of action of these polymers on wound healing. METHODS: We synthesized DBC, a newly identified ester derivative of chitin, using a patented method comprising the substitution of butyryl groups at positions C-3 and C-6 in chitin molecules. We confirmed the double substitution by the butyric groups using infrared spectrometry...
June 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/28079980/induction-of-mesenchymal-stem-cell-differentiation-in-the-absence-of-soluble-inducer-for-cutaneous-wound-regeneration-by-a-chitin-nanofiber-based-hydrogel
#19
Kangquan Shou, Yao Huang, Baiwen Qi, Xiang Hu, Zhanjun Ma, Ang Lu, Chao Jian, Lina Zhang, Aixi Yu
Transplantation of bone marrow mesenchymal stem cells (BMSCs) has been considered to be a promising strategy for wound healing. However, poor viability of engrafted BMSCs and limited capabilities of differentiation into the desired cell types in wounds often hinder its application. Few studies report the induction of BMSC differentiation into the skin regeneration-related cell types using natural biopolymer, e.g. chitin and its derivative. Here we utilized a chitin nanofiber (CNF) hydrogel as a directive cue to induce BMSC differentiation for enhancing cutaneous wound regeneration in the absence of cell-differentiating factors...
February 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28062236/enhanced-wound-healing-activity-of-desert-locust-schistocerca-gregaria-vs-shrimp-penaeus-monodon-chitosan-based-scaffolds
#20
COMPARATIVE STUDY
Narguess H Marei, W El-Mazny, Aida El-Shaer, Kareem Dorri Zaki, Zahra S Hussein, Emtithal M Abd-El-Samie
Chitosan (CS) has received great attention in tissue engineering, especially in wound healing acceleration. In this study, chitin was isolated from desert locust (Schistocerca gregaria) and shrimp (Penaeus monodon) then deacetylated to chitosan. Then, chitosan was characterized by degree of deacetylation (DD), molecular weight (M.Wt), swelling index (SI), Fourier transform infrared (FTIR) and X ray diffraction (XRD). The chitosan was then casted into 2D scaffolds and was pictured using scanning electron microscope (SEM)...
April 2017: International Journal of Biological Macromolecules
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