keyword
https://read.qxmd.com/read/38500287/use-of-chitosan-as-a-precursor-for-multiple-applications-in-medicinal-chemistry-recent-significant-contributions
#1
JOURNAL ARTICLE
Diego Quiroga, Carlos Coy-Barrera
Chitosan (CS) is a polymer made up of mainly deacetylated β-1,4 D-glucosamine units, which is part of a large group of D-glucosamine oligomers known as chitooligosaccharides, which can be obtained from chitin, most abundant natural polymer after cellulose and central component of the shrimp exoskeleton. It is known that it can be used for the development of materials, among which its use stands out in wastewater treatment (removal of metal ions, dyes, and as a membrane in purification processes), food industry (anti-cholesterol and fat, packaging material, preservative, and food additive), agriculture (seed and fertilizer coating, controlled release agrochemicals), pulp and paper industry (surface treatment, adhesive paper), cosmetics (body creams, lotions, etc...
March 18, 2024: Mini Reviews in Medicinal Chemistry
https://read.qxmd.com/read/38494231/an-overview-on-mushroom-polysaccharides-health-promoting-properties-prebiotic-and-gut-microbiota-modulation-effects-and-structure-function-correlation
#2
REVIEW
Helena Araújo-Rodrigues, Ana Sofia Sousa, João Bettencourt Relvas, Freni K Tavaria, Manuela Pintado
Mushroom polysaccharides are recognized as "biological response modifiers". Besides several bioactivities, a growing interest in their prebiotic potential has been raised due to the gut microbiota modulation potential. This review comprehensively summarizes mushroom polysaccharides' biological properties, structure-function relationship, and underlying mechanisms. It provides a recent overview of the key findings in the field (2018-2024). Key findings and limitations on structure-function correlation are discussed...
June 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38393581/evaluation-of-the-recombinant-bacterial-chitinases-as-anti-proliferative-and-anti-migratory-agents-for-the-human-breast-cancer-cell-line-mcf-7
#3
JOURNAL ARTICLE
Ankita Shrivastava, Manik Goel, Md Fahim Khalid, Geetika Sharma, Ayush Khandelwal, Disha Sharma, Rinkoo Devi Gupta
Chitinases, a glycosyl hydrolase family 18 members, have a wide distribution in both prokaryotes and eukaryotes, including humans. Regardless of the absence of endogenous chitin polymer, various chitinases and chitinase-like proteins (CLPs) have been reported in mammals. However, several other carbohydrate polymers, such as hyaluronic acid and heparan sulfate, show structural similarities with chitin, which could be a potential target of chitinase and CLPs. Heparan sulfate is part of the integral membrane proteins and involves in cell adherence and migration...
February 23, 2024: Applied Biochemistry and Biotechnology
https://read.qxmd.com/read/38348864/sprayable-hydroxypropyl-chitin-collagen-extract-of-ampelopsis-brevipedunculata-hydrogel-accelerates-wound-healing
#4
JOURNAL ARTICLE
Te-Yang Huang, Yi-Wen Wang, Hui-Xiang Liao, Wen-Ta Su
OBJECTIVE: Keeping a wound moist can allow effective and rapid healing, and it can control the formation of scabs, thereby allowing cell proliferation and epithelial formation. When regularly changing a dressing, thermosensitive hydrogel as a moist dressing does not cause a secondary wound from adhesion. The main aim of this study was to evaluate the effect of a new sprayable thermosensitive hydrogel on wound healing. METHOD: The hydrophobic N-acetyl group of chitin was removed by microwave reaction with lye until the degree of acetylation was 60%, followed by reaction with propylene oxide to obtain hydroxypropyl chitin (HPCH) with a degree of substitution of 40%...
February 1, 2024: Journal of Wound Care
https://read.qxmd.com/read/38313508/in-situ-formation-of-hydrogel-wound-dressing-based-on-carboxymethyl-chitin-tannic-acid-for-promoting-skin-wound-healing
#5
JOURNAL ARTICLE
Jinhui Lin, Siyaqi Li, Yunfei Ying, Weilin Zheng, Jingcheng Wu, Peiyuan Wang, Xiaolong Liu
Triggering the healing process of drug-resistant bacteria-infected wounds has attracted great attention due to global morbidity that may induce gangrene, amputation, and even death. Here, a chitin derivative, carboxymethyl chitosan (CMC), tannic acid (TA), and Cu2+ were used for hydrogel engineering. Using sodium bicarbonate as the neutralizer and reductant, hydrogen bonds between CMC and TA and in situ Cu(OH)2 generation via ion coordination force between Cu2+ and TA facilitated the synthesis of CMC/TA/Cu hydrogel...
January 30, 2024: ACS Omega
https://read.qxmd.com/read/38296236/-preparation-of-chitin-hyaluronic-acid-collagen-hydrogel-loaded-with-mouse-adipose-derived-stem-cells-and-its-effects-on-wound-healing-of-full-thickness-skin-defects-in-rats
#6
JOURNAL ARTICLE
Y Liu, F Cheng, Z W Wang, H X Jin, B Y Cao, P F You, A Hu, X Y Shi, J Du, Z X Yuan
Objective: To prepare the chitin/hyaluronic acid/collagen hydrogel loaded with mouse adipose-derived stem cells and to explore its effects on wound healing of full-thickness skin defects in rats. Methods: The research was an experimental research. Chitin nanofibers were prepared by acid hydrolysis and alkaline extraction method, and then mixed with hyaluronic acid and collagen to prepare chitin/hyaluronic acid/collagen hydrogels (hereinafter referred to as hydrogels). Besides, the hydrogels loaded with mouse adipose-derived stem cells were prepared...
January 20, 2024: Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi
https://read.qxmd.com/read/38181913/recent-advances-in-production-of-sustainable-and-biodegradable-polymers-from-agro-food-waste-applications-in-tissue-engineering-and-regenerative-medicines
#7
JOURNAL ARTICLE
Pinku Chandra Nath, Ramesh Sharma, Shubhankar Debnath, Prakash Kumar Nayak, Rupak Roy, Minaxi Sharma, Baskaran Stephen Inbaraj, Kandi Sridhar
Agro-food waste is a rich source of biopolymers such as cellulose, chitin, and starch, which have been shown to possess excellent biocompatibility, biodegradability, and low toxicity. These properties make biopolymers from agro-food waste for its application in tissue engineering and regenerative medicine. Thus, this review highlighted the properties, processing methods, and applications of biopolymers derived from various agro-food waste sources. We also highlight recent advances in the development of biopolymers from agro-food waste and their potential for future tissue engineering and regenerative medicine applications, including drug delivery, wound healing, tissue engineering, biodegradable packaging, excipients, dental applications, diagnostic tools, and medical implants...
January 3, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38179364/applications-of-chitosan-nanoparticles-in-dentistry-a-review
#8
REVIEW
Aastha Agrawal, Amit Reche, Sakshi Agrawal, Priyanka Paul
Recently, nanotechnology has garnered significant interest across various fields due to its emerging and diverse applications. Numerous investigators have proposed that chitosan nanoparticles (CSNPs) stand out as some of the most promising nanomaterials for facilitating various activities. Chitosan, a natural biopolymer established through the deacetylation of chitin, has been extensively studied using interdisciplinary approaches for a wide range of applications. Chitosan biomaterials exhibit distinctive attributes, including biodegradability, muco-adhesion, and biocompatibility, as well as a broad spectrum of antibacterial and antifungal properties...
December 2023: Curēus
https://read.qxmd.com/read/37962275/bacterial-cellulose-electrospun-fiber-mesh-coated-with-chitin-nanofibrils-for-eardrum-repair
#9
JOURNAL ARTICLE
Bahareh Azimi, Atefeh Rasti, Alessandra Fusco, Teresa Macchi, Claudio Ricci, Mohammad Hosseinifard, Lorenzo Guazzelli, Giovanna Donnarumma, Roohollah Bagherzadeh, Masoud Latifi, Ipsita Roy, Serena Danti, Andrea Lazzeri
In this study, we develop a bio-based and bioactive nanofibrous patch based on bacterial cellulose (BC) and chitin nanofibrils (CNs) using an ionic liquid as a solvent for BC, aimed at tympanic membrane (TM) repair. Electrospun BC nanofiber meshes were produced via electrospinning, and surface-modified with CNs using electrospray. The rheology of the BC/ionic liquid system was investigated. The obtained CN/BC meshes underwent comprehensive morphological, physico-chemical, and mechanical characterization. Cytotoxicity tests were conducted using L929 mouse fibroblasts, revealing a cell viability of 97...
November 14, 2023: Tissue Engineering. Part A
https://read.qxmd.com/read/37940287/chitosan-scaffolds-expanding-horizons-in-biomedical-applications
#10
REVIEW
Amol D Gholap, Satish Rojekar, Harshad S Kapare, Nikhar Vishwakarma, Sarjana Raikwar, Atul Garkal, Tejal A Mehta, Harsh Jadhav, Mahendra Kumar Prajapati, Uday Annapure
Chitosan, a natural polysaccharide from chitin, shows promise as a biomaterial for various biomedical applications due to its biocompatibility, biodegradability, antibacterial activity, and ease of modification. This review overviews "chitosan scaffolds" use in diverse biomedical applications. It emphasizes chitosan's structural and biological properties and explores fabrication methods like gelation, electrospinning, and 3D printing, which influence scaffold architecture and mechanical properties. The review focuses on chitosan scaffolds in tissue engineering and regenerative medicine, highlighting their role in bone, cartilage, skin, nerve, and vascular tissue regeneration, supporting cell adhesion, proliferation, and differentiation...
January 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/37940271/supramolecular-chitin-based-hydrogels-with-self-adapting-and-fast-degradation-properties-for-enhancing-wound-healing
#11
JOURNAL ARTICLE
Wenwen Shi, Dongqin Zhang, Luyao Han, Wanting Shao, Qimeng Liu, Bangyu Song, Guoqing Yan, Rupei Tang, Xuefeng Yang
Due to the features of high porosity, high water content, and tunable viscoelasticity, hydrogels have attracted numerous attentions in the promotion of wound closure. However, the lack of abilities to adapt the wounds of complex shapes and prevent postoperative adhesion limits their therapeutic outcomes in wound healing. To address the above challenges, the supramolecular chitin-based (SMCT) hydrogels are created via the host-guest pre-assembly strategy of β-cyclodextrin (βCD) and adamantane (Ad)...
January 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/37925826/soy-protein-%C3%AE-chitin-sponge-like-scaffolds-laden-with-human-mesenchymal-stromal-cells-from-hair-follicle-or-adipose-tissue-promote-diabetic-chronic-wound-healing
#12
JOURNAL ARTICLE
Kevin Las Heras, Itxaso Garcia-Orue, Jose Javier Aguirre, Koro de la Caba, Pedro Guerrero, Manoli Igartua, Edorta Santos-Vizcaino, Rosa Maria Hernandez
Chronic wounds are a worldwide problem that affect >40 million people every year. The constant inflammatory status accompanied by prolonged bacterial infections reduce patient's quality of life and life expectancy drastically. An important cell type involved in the wound healing process are mesenchymal stromal cells (MSCs) due to their long-term demonstrated immunomodulatory and pro-regenerative capacity. Thus, in this work, we leveraged and compared the therapeutic properties of MSCs derived from both adipose tissue and hair follicle, which we combined with sponge-like scaffolds (SLS) made of valorized soy protein and β-chitin...
November 1, 2023: Biomater Adv
https://read.qxmd.com/read/37879578/experimental-investigations-on-pva-chitosan-and-pva-chitin-films-for-active-food-packaging-using-oxytenanthera-abyssinica-lignin-nanoparticles-and-its-uv-shielding-antimicrobial-and-antiradical-effects
#13
JOURNAL ARTICLE
Limenew Abate Worku, Mesfin Getachew Tadesse, Archana Bachheti, D P Pandey, Anuj Kumar Chandel, Asnake Waltenigus Ewuntu, Rakesh Kumar Bachheti
This study investigated the effect of adding lignin nanoparticles (LNPs) derived from Oxytenanthera abyssinica via alkali-acid nanoprecipitation method to polyvinyl alcohol/chitosan (PVA/CI) and polyvinyl alcohol/chitin (PVA/CH) films for the active food packaging applications. Adding LNPs at concentrations of 1 % and 3 % improved the films' thermal stability and mechanical properties. The lowest water solubility and moisture content were observed in PVA/CI/LNPs films. LNPs exhibited effective 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activities, with the highest values observed in PVA/CH/LNPS and PVA/CI/LNPS films with values of 87...
October 23, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37839608/chitosan-nanoparticles-and-based-composites-as-a-biocompatible-vehicle-for-drug-delivery-a-review
#14
REVIEW
Rakshit Pathak, Shalini Bhatt, Vinay Deep Punetha, Mayank Punetha
The shellfish processing industry is one of the largest growing industries across the globe with a market size of around USD 62B. However, it also leads to a significant environmental issue as it produces >80,000 tons of waste shells globally. Unfortunately, the slow degradation of this waste causes it to accumulate over time, posing a serious threat to the marine environment. The key solution to this problem is to recycle this sea waste into a valuable product like chitin which is further used to produce chitosan...
October 13, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37686978/chitin-nanofibrils-enabled-core-shell-microcapsules-of-alginate-hydrogel
#15
JOURNAL ARTICLE
Thakur Sapkota, Bishnu Kumar Shrestha, Sita Shrestha, Narayan Bhattarai
An engineered 3D architectural network of the biopolymeric hydrogel can mimic the native cell environment that promotes cell infiltration and growth. Among several bio-fabricated hydrogel structures, core-shell microcapsules inherit the potential of cell encapsulation to ensure the growth and transport of cells and cell metabolites. Herein, a co-axial electrostatic encapsulation strategy is used to create and encapsulate the cells into chitin nanofibrils integrated alginate hydrogel microcapsules. Three parameters that are critical in the electrostatic encapsulation process, hydrogel composition, flow rate, and voltage were optimized...
September 1, 2023: Nanomaterials
https://read.qxmd.com/read/37586628/multifunctional-bilayer-membranes-composed-of-poly-lactic-acid-beta-chitin-whiskers-and-silver-nanoparticles-for-wound-dressing-applications
#16
JOURNAL ARTICLE
Amanda Grizzo, Danilo M Dos Santos, Víttor P V da Costa, Raphael G Lopes, Natalia M Inada, Daniel S Correa, Sérgio Paulo Campana-Filho
Nanomaterial-based wound dressings have been extensively studied for the treatment of both minor and life-threatening tissue injuries. These dressings must possess several crucial characteristics, such as tissue compatibility, non-toxicity, appropriate biodegradability to facilitate wound healing, effective antibacterial activity to prevent infection, and adequate physical and mechanical strength to withstand repetitive dynamic forces that could potentially disrupt the healing process. Nevertheless, the development of nanostructured wound dressings that incorporate various functional micro- and nanomaterials in distinct architectures, each serving specific purposes, presents significant challenges...
August 14, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37567696/water-soluble-aiegen-based-thermosensitive-and-antibacterial-hydroxypropyl-chitin-hydrogels-for-non-invasive-visualization-and-wound-healing
#17
JOURNAL ARTICLE
Long Huang, Mingzhen Cai, Qianqian Qiao, Taotao Li, Junyu Chen, Xulin Jiang
Antimicrobial hydrogels containing antibacterial agents have been extensively studied for postoperative infections, wound repair and tissue engineering. However, the abuse of antibiotics has led to the enhancement of bacterial resistance and traditional antibacterial agents are losing their effect. Therefore, fabricating novel and efficient antibacterial hydrogels with enhanced photodynamic antimicrobial activity, good biocompatibility, biodegradability and injectability are highly desirable for clinical application...
November 1, 2023: Carbohydrate Polymers
https://read.qxmd.com/read/37367683/high-solubility-and-bioavailability-of-lobster-shell-derived-calcium-for-significantly-proliferating-bone-and-skin-cells-in-vitro
#18
JOURNAL ARTICLE
Trung T Nguyen, Thanh Hoang, Tuyet Pham, Vi Khanh Truong, Xuan Luo, Jian Qin, Wei Zhang
Shell wastes pose environmental and financial burdens to the shellfish industry. Utilizing these undervalued shells for commercial chitin production could minimize their adverse impacts while maximizing economic value. Shell chitin conventionally produced through harsh chemical processes is environmentally unfriendly and infeasible for recovering compatible proteins and minerals for value-added products. However, we recently developed a microwave-intensified biorefinery that efficiently produced chitin, proteins/peptides, and minerals from lobster shells...
June 11, 2023: Marine Drugs
https://read.qxmd.com/read/37226781/biomedical-application-of-chitosan-and-chitosan-derivatives-a-comprehensive-review
#19
JOURNAL ARTICLE
Yash Kankariya, Bappaditya Chatterjee
Chitosan (CS) is a widely known naturally occurring polysaccharide made of chitin. The Low solubility of chitosan in water restricts its use in medical applications. However, several chemical modifications have made chitosan superior in solubility, biocompatibility, biodegradability, stability, and easy functionalization ability. All these favourable properties have increased chitosan's application in drug delivery and biomedical fields. Chitosan-based nanoparticles or biodegradable controlled-release systems are of great interest to scientists...
May 24, 2023: Current Pharmaceutical Design
https://read.qxmd.com/read/37211070/applications-and-perspectives-of-quaternized-cellulose-chitin-and-chitosan-a-review
#20
REVIEW
Ke-Xin Huang, Ling-Yue Zhou, Jia-Qi Chen, Na Peng, Hong-Xiang Chen, Hua-Zhi Gu, Tao Zou
Recently, increasing attention has been paid to natural polysaccharides for their low cost, biocompatibility and biodegradability. Quaternization is a modification method to improve the solubility and antibacterial ability of natural polysaccharides. Water-soluble derivatives of cellulose, chitin and chitosan offer the prospect of diverse applications in a wide range of fields, such as antibacterial products, drug delivery, wound healing, sewage treatment and ion exchange membranes. By combining the inherent properties of cellulose, chitin and chitosan with the inherent properties of the quaternary ammonium groups, new products with multiple functions and properties can be obtained...
May 19, 2023: International Journal of Biological Macromolecules
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