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https://www.readbyqxmd.com/read/29667744/intraurethral-erbium-yag-laser-for-the-management-of-urinary-symptoms-of-genitourinary-syndrome-of-menopause-a-pilot-study
#1
Adrian Gaspar, Sandra Maestri, Joaquin Silva, Hugo Brandi, Daniel Luque, Neža Koron, Zdenko Vižintin
OBJECTIVES: Genitourinary syndrome of menopause (GSM) combines the conditions of vulvovaginal atrophy (VVA) and urinary tract dysfunction, which is a result of urethral atrophy. There are several treatment methods available for the management of vulvovaginal symptoms of GSM, whereas urinary tract dysfunction often remains overlooked and undertreated. The objective of this pilot study was to assess the safety and efficacy of intraurethral Er:YAG laser treatment of urinary symptoms of GSM...
April 18, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29664771/effects-of-1-540-nm-fractional-nonablative-erbium-and-2-940-nm-fractional-ablative-erbium-on-p53-epidermal-expression-after-3-months-a-split-face-interventional-study
#2
Juliano Borges, Luciana Araújo, Rodrigo P B de Oliveira, Monica Manela-Azulay
BACKGROUND: Expression of p53 by keratinocytes may be important in the pathogenesis of skin cancer induced by ultraviolet light. OBJECTIVE: We used side-by-side nonablative and ablative erbium fractional laser resurfacing to assess the effects on expression of p53 by facial keratinocytes. METHODS: Ten female patients (age range, 50-63 years) with Fitzpatrick skin Types I-IV and clinical signs of photoaging underwent erbium fractional laser resurfacing (nonablative, 1,540-nm; ablative, 2,940-nm) on opposite sides of the face...
April 16, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29664243/new-technologies-and-techniques-for-prostate-cancer-focal-therapy-a-review-of-the-current-literature
#3
Estefanía Linares-Espinós, Arie Carneiro, Juan I Martínez-Salamanca, Fernando Bianco, Adalberto Castro-Alfaro, Xavier Cathelineau, Massimo Valerio, Rafael Sanchez-Salas
BACKGROUND: The aim of this study was to review the oncological and functional outcomes of new and established primary focal treatments (FT) for localized prostate cancer (PCa). METHODS: We performed a systematic search of published studies on FT for localized PCa using electronic databases (Medline and Embase). These studies included reports on hemiablation, focal ablation and target-ablation. We excluded salvage focal therapy studies and limited the search to those with a minimum of 12 months of follow-up...
April 16, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29663518/potentially-malignant-disorders-revisited-the-lichenoid-lesion-proliferative-verrucous-leukoplakia-conundrum
#4
P J Thomson, M L Goodson, D R Smith
BACKGROUND: Clinically identifiable potentially malignant disorders (PMD) precede oral squamous cell carcinoma development. Oral lichenoid lesions (OLL) and proliferative verrucous leukoplakia (PVL) are specific precursor lesions believed to exhibit both treatment resistance and a high risk of malignant transformation (MT). METHODS: A retrospective review of 590 PMD patients treated in Northern England by CO2 laser surgery between 1996 and 2014 was carried out. Lesions exhibiting lichenoid or proliferative verrucous features were identified from the patient database and their clinico-pathological features and outcome post-treatment determined at the study census date of 31 December 2014...
April 16, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29663460/treatment-of-atrophic-acne-scarring-with-fractional-micro-plasma-radio-frequency-in-chinese-patients-a-prospective-study
#5
Ting Lan, Yan Xiao, Li Tang, Michael R Hamblin, Rui Yin
BACKGROUND: Acne scarring is a common disfiguring sequela of acne vulgaris which can lead to serious psychosocial problems and have a negative effect on patients' quality of life. Although a variety of approaches can be used to treat atrophic acne scars, disadvantages such as long-healing time, dyspigmentation, infections, and prolonged erythema make these treatments unsatisfactory especially for Asians. Fractional micro-plasma radio-frequency is a novel technology that produces minor ablation to the epidermis to promote rapid re-epithelialization, while the radio-frequency evoked thermal effect can stimulate regeneration and remodeling of dermal fibroblasts...
April 16, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29663058/geochemical-wolframite-fingerprinting-the-likelihood-ratio-approach-for-laser-ablation-icp-ms-data
#6
Agnieszka Martyna, Hans-Eike Gäbler, Andreas Bahr, Grzegorz Zadora
Wolframite has been specified as a 'conflict mineral' by a U.S. Government Act, which obliges companies that use these minerals to report their origin. Minerals originating from conflict regions in the Democratic Republic of the Congo shall be excluded from the market as their illegal mining, trading, and taxation are supposed to fuel ongoing violent conflicts. The German Federal Institute for Geosciences and Natural Resources (BGR) developed a geochemical fingerprinting method for wolframite based on laser ablation inductively coupled plasma-mass spectrometry...
April 17, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29662707/percutaneous-ethanol-injection-in-combination-with-laser-ablation-for-a-100-ml-partially-cystic-thyroid-nodule
#7
Roberto Negro, Gabriele Greco
Until nonsurgical techniques like laser ablation (LA) or radiofrequency became available, patients suffering from large nodules with compressive symptoms were addressed to surgery. We describe the case of a 59-year-old woman with a large, partially cystic thyroid nodule having a volume of about 100 ml. As the patient refused surgery, despite her constant local discomfort, such large partially cystic nodule underwent several percutaneous ethanol injections (PEI) and then was submitted to LA. The combination of these two procedures allowed firstly complete disappearance of the cystic component and secondly a significant reduction of thyroid nodule, which finally measured 17 ml in volume (82% reduction compared to baseline)...
2018: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/29660407/application-of-water-soluble-polyvinyl-alcohol-based-film-patches-on-laser-microporated-skin-facilitates-intradermal-macromolecule-and-nanoparticle-delivery
#8
Laura Engelke, Gerhard Winter, Julia Engert
The intradermal delivery of biologics has long been recognized as attractive approach for cutaneous immunotherapy, particularly vaccination. Although intradermal (i.d.) or subcutaneous (s.c.) injection provide reproducible dosing and good cost- and delivery efficiency, the major objective to avoid sharps and the need for enhanced storage stability have renewed the interest in alternative needle-free delivery strategies. This study presents a new concept for the delivery of macromolecules and nanoparticles to viable skin layers with a high density of professional antigen-presenting cells (APCs)...
April 13, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29658705/tungsten-hydride-phosphorus-and-arsenic-bearing-molecules-with-double-and-triple-w-p-and-w-as-bonds
#9
Lester Andrews, Han-Gook Cho, Zongtang Fang, Monica Vasiliu, David A Dixon
Laser ablation of tungsten metal provides W atoms which react with phosphine and arsine during condensation in excess argon and neon, leading to major new infrared (IR) absorptions. Annealing, UV irradiation, and deuterium substitution experiments coupled with electronic structure calculations at the density functional theory level led to the assignment of the observed IR absorptions to the E≡WH3 and HE═WH2 molecules for E = P and As. The potential energy surfaces for hydrogen transfer from PH3 to the W were calculated at the coupled-cluster CCSD(T)/complete basis set level...
April 16, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29657748/a-study-of-laser-surface-treatment-in-bonded-repair-of-composite-aircraft-structures
#10
Shaolong Li, Ting Sun, Chang Liu, Wenfeng Yang, Qingru Tang
Surface pre-treatment is one of the key processes in bonded repair of aircraft carbon fibre reinforced polymer composites. This paper investigates the surface modification of physical and chemical properties by laser ablation and conventional polish treatment techniques. Surface morphology analysed by laser scanning confocal microscopy and scanning electron microscopy showed that a laser-treated surface displayed higher roughness than that of a polish-treated specimen. The laser-treated laminate exhibited more functional groups in the form of O 1 s/C 1 s atomic ratio of 30...
March 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29655811/retrograde-endovenous-laser-therapy-facilitates-great-saphenous-vein-closure-in-the-setting-of-severe-vasospasm
#11
Ravi N Srinivasa, Rajiv N Srinivasa, Nathan Kafity, Michael Cline, Anthony N Hage, Joseph J Gemmete, Jeffrey Forris Beecham Chick
Antegrade access for endovenous laser therapy may be technically challenging due to patient body habitus, vasospasm, dehydration, and poor visibility of vasculature. This report describes a retrograde approach from the contralateral femoral vein to facilitate laser ablation of the great saphenous vein in the setting of vasospasm. Such a technique may provide a viable alternative in technically difficult situations.
April 12, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29652833/a-lipophilic-ir-780-dye-encapsulated-zwitterionic-polymer-lipid-micellar-nanoparticle-for-enhanced-photothermal-therapy-and-nir-based-fluorescence-imaging-in-a-cervical-tumor-mouse-model
#12
Santhosh Kalash Rajendrakumar, Ning-Chu Chang, Adityanarayan Mohapatra, Saji Uthaman, Byeong-Il Lee, Wei-Bor Tsai, In-Kyu Park
To prolong blood circulation and avoid the triggering of immune responses, nanoparticles in the bloodstream require conjugation with polyethylene glycol (PEG). However, PEGylation hinders the interaction between the nanoparticles and the tumor cells and therefore limits the applications of PEGylated nanoparticles for therapeutic drug delivery. To overcome this limitation, zwitterionic materials can be used to enhance the systemic blood circulation and tumor-specific delivery of hydrophobic agents such as IR-780 iodide dye for photothermal therapy...
April 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29652390/integrated-catheter-for-simultaneous-radio-frequency-ablation-and-optoacoustic-monitoring-of-lesion-progression
#13
Johannes Rebling, Francisco Javier Oyaga Landa, Xosé Luís Deán-Ben, Alexandre Douplik, Daniel Razansky
Radio frequency (RF) catheter ablation is commonly used to eliminate dysfunctional cardiac tissue by heating via an alternating current. Clinical outcomes are highly dependent on careful anatomical guidance, electrophysiological mapping, and careful RF power titration during the procedure. Yet, current treatments rely mainly on the expertise of the surgeon to assess lesion formation, causing large variabilities in the success rate. We present an integrated catheter design suitable for simultaneous RF ablation and real-time optoacoustic monitoring of the forming lesion...
April 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29652086/five-year-follow-up-of-a-randomized-clinical-trial-comparing-open-surgery-foam-sclerotherapy-and-endovenous-laser-ablation-for-great-saphenous-varicose-veins
#14
S Vähäaho, K Halmesmäki, A Albäck, E Saarinen, M Venermo
BACKGROUND: New treatment methods have challenged open surgery as a treatment for great saphenous vein (GSV) insufficiency, the most common being ultrasound-guided foam sclerotherapy (UGFS) and endovenous laser ablation (EVLA). This study evaluated the long-term results of surgery, EVLA and UGFS in the treatment of GSV reflux. METHODS: Patients with symptomatic GSV reflux were randomized to undergo either open surgery, EVLA or UGFS. The main outcome measure was the occlusion rate of the GSV at 5 years after operation...
May 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29648446/evans-blue-derivative-functionalized-gold-nanorods-for-photothermal-therapy-enhanced-tumor-chemotherapy
#15
Xiangyu Wang, Shi Gao, Zainen Qin, Rui Tian, Guohao Wang, Xianzhong Zhang, Lei Zhu, Xiaoyuan Chen
Chemotherapy is a standard care for cancer management, but the lack of tumor targeting and high dose-induced side effects still limit its utility in patients. Here, we report a chemotherapy combined with photothermal therapy (PTT) for enhanced cancer ablation by functionalization of gold nanorods (GNR) with a novel small molecule named truncated Evans Blue (tEB). Based on the high binding affinity of tEB with albumin, an Abraxane-like nanodrug, human serum albumin/hydroxycamptothecin (HSA/HCPT), was further complexed with GNR-tEB...
April 12, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29629891/ureterocele-fenestration-with-holmium-laser-in-neonates
#16
Predrag Ilic, Mirjana Jankovic, Maja Milickovic, Slobodan Dzambasanovic, Vladimir Kojovic
AIM: To evaluate the effectiveness of holmium-laser fenestration of intravesical ureteroceles in neonatal period. MATERIAL AND METHOD: We retrospectively analyzed the results of the holmium-laser puncture in ten neonates with intravesical ureterocele, between September 2013 and September 2016. Laser probe was placed through the cystoscope to the lowest and medial portion of the ureterocele, near the bladder floor. Few punctures (4 to 8) were made, until ureterocele has been collapsed...
2018: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29627979/in-vitro-and-in-vivo-photothermal-cancer-therapeutic-effect-of-mushroom-%C3%AE-glucan-modified-gold-nanorods
#17
Xiaojie Li, Jiajing Zhou, Xiaonan Dong, Wai-Yin Cheng, Hongwei Duan, Peter C K Cheung
The photothermal cancer therapeutic effect of the AuNR-Glu nanohybrids produced by coating the native gold nanorods (AuNRs) with a natural mushroom biopolymer from Pleurotus tuber-regium sclerotial β-glucan (Glu) were studied in the second near infrared window (NIR-II). AuNR-Glu showed low cytotoxicity and highly biocompatibility due to the surface coating of Glu when compared with the native AuNRs. AuNR-Glu nanohybrids had a high photothermal transduction efficiency (η) of 43.12%, causing effective in vitro cell ablation (over 90% cell death) in both HT-29 (94...
April 7, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29627130/patient-satisfaction-after-fractional-ablation-of-burn-scar-with-2940nm-wavelength-erbium-yag-laser
#18
Tarik D Madni, Paul A Nakonezny, Jonathan B Imran, Audra T Clark, Holly B Cunningham, John E Hoopman, Brett D Arnoldo, Steven E Wolf, Jeffrey M Kenkel, Herb A Phelan
OBJECTIVE: Fractional laser therapy is a new treatment with potential benefit in the treatment of burn scars. We sought to determine patient satisfaction after burn scar treatment with the Erbium-Yag laser. METHODS: We performed a telephone survey of all patients who underwent fractional resurfacing of burn scars with the Erbium-Yag 2940 wavelength laser at Parkland Hospital from 01/01/2016 to 05/01/2017. Subjects were asked to rate their satisfaction with their scars' after treatment characteristics on a scale from 1 (completely unsatisfied) to 10 (completely satisfied)...
April 4, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29626814/effect-of-nitrogen-plasma-afterglow-on-the-surface-charge-effect-resulted-during-xps-surface-analysis-of-amorphous-carbon-nitride-thin-films
#19
Kamal Kayed
The aim of this paper is to investigate the relationship between the micro structure and the surface charge effect resulted during XPS surface analysis of amorphous carbon nitride thin films prepared by laser ablation method. The study results show that the charge effect coefficient (E) is not just a correction factor. We found that the changes in this coefficient value due to incorporation of nitrogen atoms into the carbon network are related to the spatial configurations of the sp2 bonded carbon atoms, order degree and sp2 clusters size...
March 27, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29626502/sustained-release-of-anti-pd-1-peptide-for-perdurable-immunotherapy-together-with-photothermal-ablation-against-primary-and-distant-tumors
#20
Lihua Luo, Jie Yang, Chunqi Zhu, Mengshi Jiang, Xiaomeng Guo, Wei Li, Xiaoyi Yin, Hang Yin, Bin Qin, Xiaoling Yuan, Qingpo Li, Yongzhong Du, Jian You
Immune checkpoint PD-1/PD-L1 blockade has emerged as a successful immunotherapy strategy for treating several types of malignant tumors. A constant and proper drug concentration during the treatment is important because the long-term activation of the immune system is urgently needed to perdurably recognize and attack cancer cells for a better therapeutic effect with minimum side effects. However, practically few related studies have been reported to date. In this study, we constructed a therapeutic strategy combining PD-1 blocking with photothermal ablation for malignant tumors by co-encapsulating anti-PD-1 peptide (APP) and hollow gold nanoshell (HAuNS) into biodegradable Poly (d, l-lactic-co-glycolide) nanoparticles (APP- and HAuNS-loaded PLGA nanoparticles, AA@PN)...
April 4, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
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