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Surgery pathology

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https://www.readbyqxmd.com/read/29691737/salvage-abdominoperineal-resection-for-squamous-cell-anal-cancer-a-30-year-single-institution-experience
#1
J A W Hagemans, S E Blinde, J J Nuyttens, W G Morshuis, M A M Mureau, J Rothbarth, C Verhoef, J W A Burger
BACKGROUND: Failure of chemoradiotherapy (CRT) for anal squamous cell carcinoma (SCC) results in persistent or recurrent anal SCC. Treatment with salvage abdominoperineal resection (APR) can potentially achieve cure. The aims of this study are to analyze oncological and surgical outcomes of our 30-year experience with salvage APR for anal SCC after failed CRT and identify prognostic factors for overall survival (OS). METHODS: All consecutive patients who underwent salvage APR between 1990 and 2016 for histologically confirmed persistent or recurrent anal SCC after failed CRT were retrospectively analyzed...
April 24, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29691623/minimally-invasive-versus-open-treatment-for-benign-sporadic-insulinoma-comparison-of-short-term-and-long-term-outcomes
#2
Giulio Belfiori, Dominik Wiese, Stefano Partelli, Sabine Wächter, Elisabeth Maurer, Stefano Crippa, Massimo Falconi, Detlef K Bartsch
BACKGROUND: Benign insulinoma is the most common functioning neuroendocrine tumor of the pancreas, and its incidence is estimated at 0.4%. The treatment of choice is organ-preserving resection. The aim of this study was to compare short-term and long-term outcomes of minimally invasive laparoscopic or robotic enucleation (MIC-EN) and open enucleation (O-EN) for sporadic benign insulinoma. METHODS: A retrospective bi-institutional analysis of 71 patients who underwent an enucleation for sporadic benign insulinoma between 2003 and 2016 was performed...
April 24, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29691620/laparoscopic-proximal-gastrectomy-maintains-body-weight-and-skeletal-muscle-better-than-total-gastrectomy
#3
Masahiko Sugiyama, Eiji Oki, Koji Ando, Yuichiro Nakashima, Hiroshi Saeki, Yoshihiko Maehara
BACKGROUND: Laparoscopic proximal gastrectomy (LPG) is performed as a function-preserving surgery for patients with early proximal gastric malignant tumors; however, whether LPG has advantages postoperatively compared with laparoscopic total gastrectomy (LTG) is debatable, especially with regard to nutritional outcomes. METHODS: We evaluated 20 patients who underwent LTG and 10 patients who underwent LPG with double tract reconstruction (LPG-DT) who were diagnosed preoperatively with T1a or T1b N0 Stage IA gastric cancer in our department in the same time period...
April 24, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29691554/-retrospective-analysis-of-896-cases-of-parotid-gland-tumor
#4
Zhi-Guo Zhao, Dan Gao, Jin Wang, Li-Ping Zhang
PURPOSE: To review the clinical data of patients undergoing operation, in order to summarize the incidence, proportion, clinical examination and diagnostic methods of parotid tumors. METHODS: Eight hundred and ninty-six cases of parotid gland tumors were collected from 2008 January to 2015 July from department of oral and maxillofacial surgery in Shengjing Hospital of China Medical University. A retrospective study of the clinical data was carried out, including age, gender, tumor location, diagnostic methods and pathological results...
December 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/29691415/adjuvant-chemotherapy-after-surgery-can-improve-clinical-outcomes-for-patients-with-ib2-iib-cervical-cancer-with-neoadjuvant-chemotherapy-followed-by-radical-surgery
#5
Haiying Sun, Kecheng Huang, Fangxu Tang, Xiong Li, Xiaoli Wang, Sixiang Long, Shasha Zhou, Suolangquzhen, Jianwei Zhang, Ruoqi Ning, Shuang Li, Shixuan Wang, Ding Ma
The aim of the study is to evaluate the efficacy of postoperative treatments based on pathological response for cervical cancer patients who received neoadjuvant chemotherapy (NACT) followed by radical surgery. Firstly, a total of 756 cervical squamous cell cancer (SCC) patients with FIGO IB2-IIB were included in this retrospective study. Then data from a prospective cohort of 393 patients was employed for further validation. Overall survival (OS) and disease-free survival (DFS) were assessed. In the retrospective study, SCC patients who accepted adjuvant chemotherapy after radical surgery had a relatively better OS than those who received no therapy (P = 0...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29691094/first-experience-of-the-egyptian-national-cancer-institute-using-the-robot-assisted-laparoscopic-approach-in-radical-hysterectomies-for-cervical-cancer
#6
Ashraf Saad Zaghloul, Ahmed Mahmoud El-Minawi, Mohamed Atef ElKordy, Amr Kamal Younes, Ahmed Mostafa Mahmoud, Waleed Mohamed Fadlalla, Gamal Amira Mohamed
AIM OF WORK: Robotics in surgery led to an improvement of visualization, a better handling of tissues and better suturing. This study aimed to document the first experience of the Egyptian National Cancer Institute (NCI) using the robot-assisted laparoscopic approach in radical hysterectomies for cervical cancer and to highlight observed advantages, disadvantages, morbidity and oncological outcomes. PATIENTS AND METHODS: Data of cases that had either early cervical cancer (stage IB-IIA1 with a tumor ≥2 cm) or locally advanced cervical cancer (Stage IIA2-IIB after chemo-radiotherapy) were collected prospectively...
April 21, 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29690869/concurrent-presentation-of-an-intraductal-tubulopapillary-neoplasm-and-intraductal-papillary-mucinous-neoplasm-in-the-branch-duct-of-the-pancreas-with-a-superior-mesenteric-artery-aneurysm-a-case-report
#7
Kenta Inomata, Minoru Kitago, Hideaki Obara, Yoko Fujii-Nishimura, Masahiro Shinoda, Hiroshi Yagi, Yuta Abe, Taizo Hibi, Kentaro Matsubara, Go Oshima, Yasuhito Sekimoto, Masazumi Inoue, Osamu Itano, Michiie Sakamoto, Yuko Kitagawa
BACKGROUND: Since the concept of intraductal tubulopapillary neoplasm (ITPN) was introduced in the current World Health Organization classification of tumors, the number of reports of ITPN occurrence has increased gradually. However, ITPN is usually located in the main pancreatic duct, with few reports of a branch duct ITPN. As a result, imaging protocols for the diagnosis of a branch duct ITPN have not been established. CASE PRESENTATION: We report a case of a concurrent presentation of a branch duct ITPN and intraductal papillary mucinous neoplasm (IPMN) in the head of the pancreas, with a superior mesenteric artery (SMA) aneurysm...
April 24, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29690812/analysis-of-orthopedic-surgery-of-patients-with-metastatic-bone-tumors-and-pathological-fractures
#8
Resit Sevimli, Mehmet Fatih Korkmaz
Objective This study was performed to determine the most common causes, locations, and treatments of metastasizing primary tumors through evaluation of patients with metastatic bone tumors who were admitted to our clinic. Methods In total, 96 patients with metastatic bone tumors who were admitted to our clinic from 2000 to 2016 were included in the study. Results The breast (30 patients, 31.3%) and lung (18 patients, 18.8%) were the most commonly metastasized primary organs. The femur was the most commonly metastasized bone...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29690667/-clinicopathologic-characterisitics-of-pancreatic-acinar-cell-carcinomas
#9
X H Ding, Z B Wang, X M Qiu
Objective: To investigate clinical, pathological and immunohistochemical features of pancreatic acinar cell carcinoma. Methods: A retrospective review of surgical and pathological databases between 2011 and 2016 at PLA General Hospital was collected and 14 cases of acinar cell carcinoma (ACC) of the pancreas were identified. EnVision immunohistochemistry was used to detect the expression of Trypsin, bcl-10 and cytokeratin(CK) proteins. Results: The patients included nine cases of pure ACC, 3 cases of mixed acinar ductal carcinoma, 1 case of mixed acinar-neuroendocrine carcinoma and acinar-ductal-neuroendocrine carcinoma, respectively...
April 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29689399/primary-focal-intracranial-leptomeningeal-glioma-pfilg-a-case-report-and-review-of-literature
#10
Vinayak Narayan, Amey Savardekar, Nasser Mohammed, Devi Prasad Patra, Maria-Magdalena Georgescu, Anil Nanda
BACKGROUND: Primary focal intracranial leptomeningeal glioma [PFILG] is considered as a rare solitary glial tumor arising from the leptomeninges without brain attachment or evidence of primary neoplasm elsewhere within the neuraxis. We herein report a case of PFILG in left parietal location with a concise review on its clinico-radiological, histopathological and management characteristics. CASE PRESENTATION: A 75 year old lady presented with focal motor seizures involving right upper limb with associated occasional headache...
April 21, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29688948/hepatic-hemangioma-on-spect-myocardial-perfusion-imaging
#11
Susan Taylor, Tricia Francisco, Janet A Munroe, Hadyn T Williams
Extracardiac uptake on SPECT MPI, seen with physiologic radiotracer distribution, benign or malignant neoplasm, infection, inflammation, or granulomatous disease, may confound the accuracy of MPI or lead to unsuspected pathology. A 38-year-old woman with end-stage renal disease on hemodialysis had SPECT MPI for renal transplant preoperative risk stratification, showing left anterior descending artery ischemia and an intense extracardiac soft tissue focus adjacent to the diaphragmatic right ventricle concerning for focal infection related to prior coronary or gastric surgeries or tumor...
April 23, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29688906/selected-proliferation-markers-correlated-with-dynamics-of-growth-in-colorectal-cancer
#12
Wu-Xia Luo, Ye Chen, Yun-Tao Li, Jie Tang, Jing Ding, Yang Du, Qiang Wu, Ji-Yan Liu
For treatment of metastatic colorectal cancer, the dynamics of tumor growth is an important factor for treatment decision. However, it is difficult to evaluate the dynamics of tumor growth, especially those of synchronous metastatic diseases. This study aimed to find some indicators related to tumor proliferation to judge the dynamics of tumor progression. The pathological reports and clinical data of 1205 patients with metastatic colorectal cancer were retrospectively reviewed; 75 patients with known relapse time after radical resection were included, and the expression of proliferation-associated proteins was detected by immunohistochemistry...
April 23, 2018: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29688749/surgical-treatment-with-closing-wedge-distal-femoral-osteotomy-for-recurrent-patellar-dislocation-with-genu-valgum
#13
Kyung Wook Nha, Yoonwon Ha, Seungmin Oh, Vivek P Nikumbha, Sae Kwang Kwon, Woo-Jin Shin, Byung Hoon Lee, Keun Bae Hong
BACKGROUND: Closing-wedge distal femoral osteotomy (CWDFO)-combined with medial reefing and lateral release, if necessary- has been used to treat recurrent patellar dislocation (RPD) with genu valgum. PURPOSE: To evaluate the clinical and radiologic outcomes of surgical treatment with CWDFO for treatment of RPD with genu valgum. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: Fourteen consecutive patients (23 knees) with RPD and genu valgum were treated with CWDFO...
April 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29688180/patient-selection-echocardiographic-screening-and-treatment-strategies-for-interventional-tricuspid-repair-using-the-edge-to-edge-repair-technique
#14
Jörg Hausleiter, Daniel Braun, Mathias Orban, Azeem Latib, Philipp Lurz, Peter Boekstegers, Ralph Stephan von Bardeleben, Marek Kowalski, Rebecca T Hahn, Francesco Maisano, Christian Hagl, Steffen Massberg, Michael Nabauer
Severe tricuspid regurgitation (TR) has long been neglected despite its well known association with mortality. While surgical mortality rates remain high in isolated tricuspid valve surgery, interventional TR repair is rapidly evolving as an alternative to cardiac surgery in selected patients at high surgical risk. Currently, interventional edge-to-edge repair is the most frequently applied technique for TR repair even though the device has not been developed for this particular indication. Due to the inherent differences in tricuspid and mitral valve anatomy and pathology, percutaneous repair of the tricuspid valve is challenging due to a variety of factors including the complexity and variability of tricuspid valve anatomy, echocardiographic visibility of the valve leaflets, and device steering to the tricuspid valve...
April 24, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29687970/hybrid-arch-surgery-challenges-other-forms-of-arch-treatment
#15
Tyler J Wallen, Joseph E Bavaria, Prashanth Vallabhajosyula
INTRODUCTION: The gold standard for aortic arch replacement remains total arch replacement (TAR) procedure. Hybrid techniques, utilizing a combination of open and endovascular approaches, have been developed with goal of lowering postoperative mortality and morbidity, as well as providing an alternative therapy for patients who are elderly, have significant comorbid burden, or patients in whom circulatory arrest may pose significant risk. EVIDENCE ACQUISITION: To date, there are no prospective randomized trials comparing hybrid aortic ach procedures to TAR...
April 24, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29687851/mir-132-weakens-proliferation-and-invasion-of-glioma-cells-via-the-inhibition-of-gli1
#16
Y-Z Wang, J-J Han, S-Q Fan, W Yang, Y-B Zhang, T-J Xu, G-M Xu
OBJECTIVE: Transcriptional factor Gli1 in Hedgehog signal pathway facilitates epithelial mesenchymal transition (EMT) and is associated with invasion or proliferation of multiple tumor cells. The previous study showed the correlation between miR-132 down-regulation and glioma pathogenesis. We investigated the role of miR-132 in mediating Gli1 expression and in affecting proliferation or invasion of glioma cells. PATIENTS AND METHODS: Dual luciferase reporter gene assay was used to confirm the targeted regulation between miR-132 and Gli1...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29687535/management-of-intraductal-papilloma-without-atypia-of-the-breast-diagnosed-on-core-biopsy-size-and-sampling-matter
#17
Brittany Symbol, Andrew Ricci
Due to the potential for atypia (atypical ductal or lobular hyperplasia) or carcinoma (in situ or invasive) on excision, aggressive reflex surgical excision protocols following core biopsy diagnosis of papillary lesions of the breast (ie, intraductal papilloma) are commonplace. Concepts in risk stratification, including radiologic-pathologic correlation, are emerging in an effort to curb unnecessary surgeries. To this end, we examined all excised intraductal papillomas diagnosed at our institution from 2010-2015 (N = 336) and found an overall atypia rate of 20%...
April 23, 2018: Breast Journal
https://www.readbyqxmd.com/read/29687424/platelet-to-lymphocyte-ratio-and-neutrophil-to-lymphocyte-ratio-are-not-prognostic-biomarkers-in-rectal-cancer-patients-with-curative-resection
#18
Giuseppe Portale, Francesco Cavallin, Alessandro Valdegamberi, Flavio Frigo, Valentino Fiscon
BACKGROUND: Actual predictors of survival and recurrence for rectal cancer patients undergoing curative resection mostly come from pathological data of surgical specimen. Recently, novel blood biomarkers have been proposed as useful tools in cancer patient management, but few and conflicting data have been reported in rectal cancer. We evaluated the prognostic relevance of preoperative platelet-to-lymphocyte (P/L) ratio and neutrophil-to-lymphocyte (N/L) ratio on survival and recurrence in patients undergoing laparoscopic curative resection for rectal cancer...
April 23, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29687253/real-time-intraoperative-contrast-enhanced-ultrasound-ceus-in-vascularized-spinal-tumors-a-technical-note
#19
Giuseppe Maria Della Pepa, Pier Paolo Mattogno, Giuseppe La Rocca, Giovanni Sabatino, Alessandro Olivi, Luca Ricciardi, Filippo Maria Polli
BACKGROUNDS: Intra-operative ultrasound (ioUS), and the recently introduced contrast-enhanced ultrasound (CEUS) demonstrated to be an extremely valuable tool in oncological cerebral neurosurgery. METHODS: The authors applied ioUS/CEUS techniques to spinal oncological surgery as showed in the illustrative case of a dorsal hemangiopericytoma. RESULTS AND CONCLUSIONS: ioUS and CEUS provide real-time information that proved useful in identifying both vascular and parenchymatous tumoral patterns, anatomical relations with nervous structure, plan surgical strategy, and identify residuals...
April 23, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29686971/snapping-elbow-a-guide-to-diagnosis-and-treatment
#20
Jonathan Jetsmark Bjerre, Finn Elkjær Johannsen, Martin Rathcke, Michael Rindom Krogsgaard
AIM: To develop practical guidelines for diagnosis and treatment of the painful snapping elbow syndrome (SE). METHODS: Clinical studies were searched in the databases PubMed and Scopus for the phrases "SE", "snapping triceps", "snapping ulnar nerve" and "snapping annular ligament". A total of 36 relevant studies were identified. From these we extracted information about number of patients, diagnostic methods, patho-anatomical findings, treatments and outcomes...
April 18, 2018: World Journal of Orthopedics
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