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https://www.readbyqxmd.com/read/28822967/temporal-dynamics-of-cardiac-hypertrophic-growth-in-response-to-pressure-overload
#1
Yuan Wang, Yuannyu Zhang, Guanqiao Ding, Herman May, Jian Xu, Thomas G Gillette, Hang Wang, Zhao V Wang
Hypertension is one of the most important risk factors of heart failure. In response to high blood pressure, the left ventricle manifests hypertrophic growth to ameliorate wall stress, which may progress into decompensation and trigger pathological cardiac remodeling. Despite the clinical importance, the temporal dynamics of pathological cardiac growth remains elusive. Here, we took advantage of the puromycin labeling approach to measure the relative rates of protein synthesis as a way to delineate the temporal regulation of cardiac hypertrophic growth...
August 19, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28822872/different-mossy-fiber-sprouting-patterns-in-ilae-hippocampal-sclerosis-types
#2
Barbara Schmeiser, Jinmei Li, Armin Brandt, Josef Zentner, Soroush Doostkam, Thomas M Freiman
OBJECTIVE: Hippocampal sclerosis (HS) is the most prevalent pathology in temporal lobe epilepsy (TLE) characterized by segmental neuronal cell loss in the cornu ammonis (CA) 1-4. In addition, migration of granule cells and reorganization of their axons is observed, known as granule cell dispersion (GCD) and mossy fiber sprouting (MFS). The loss of mossy fibers` (MF) target cells in CA4 and CA3 was considered to be causative for MFS. The ILAE HS (International League Against Epilepsy) classification identifies three subtypes with different cell loss patterns in CA1-4...
August 8, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28822640/comparison-of-outcomes-1%C3%A2-year-after-rotator-cuff-repair-with-and-without-concomitant-biceps-surgery
#3
Scott T Watson, Christopher B Robbins, Asheesh Bedi, James E Carpenter, Joel J Gagnier, Bruce S Miller
PURPOSE: To compare the outcomes of patients who undergo a long head of the biceps (LHB) procedure (tenotomy or tenodesis) concomitant with rotator cuff repair (RCR) to those of patients who undergo isolated RCR. METHODS: Prospectively collected data were retrospectively reviewed on 80 patients, >18 years old, who underwent repair of a full-thickness rotator cuff tear and with 1-year patient-reported outcome scores collected June 2012 to March 2015. The exclusion criteria were concomitant procedures other than LHB tenotomy, tenodesis, or subacromial decompression; prior shoulder surgery; or other shoulder pathology...
August 16, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28822637/porcine-dermis-patch-augmentation-of-supraspinatus-tendon-repairs-a-pilot-study-assessing-tendon-integrity-and-shoulder-function-2%C3%A2-years-after-arthroscopic-repair-in-patients-aged-60%C3%A2-years-or%C3%A2-older
#4
Matthias Flury, Dominik Rickenbacher, Christian Jung, Marco M Schneider, David Endell, Laurent Audigé
PURPOSE: To investigate the 2-year postoperative clinical and subjective outcomes after arthroscopic rotator cuff repair (ARCR) with xenologous porcine dermal patch augmentation compared with ARCR alone. METHODS: Patients aged 60 years or older with a complete supraspinatus (SSP) tendon tear underwent primary ARCR with a transosseous-equivalent technique. By use of a matched-pair comparative trial design, a consecutive series of 20 patients receiving additional xenologous porcine dermal patch augmentation (patch group) was matched by tear location with 20 patients who received ARCR only (control group)...
August 16, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28822555/influence-of-tumor-size-on-outcomes-following-pelvic-exenteration
#5
B Smith, E L Jones, M Kitano, A L Gleisner, N J Lyell, G Cheng, M D McCarter, S Abdel-Misih, F J Backes
OBJECTIVE: Pelvic exenteration (PE) is often the only curative option for locally advanced or recurrent pelvic malignancies. Despite radical surgery, recurrence risk and morbidity remain high. In this study, we sought to determine tumor size effect on perioperative outcomes and subsequent survival in patients undergoing PE. METHODS: Retrospective chart review was performed for female patients who underwent PE at two comprehensive cancer centers from 2000 to 2015...
August 16, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28820653/fibrous-skeleton-of-the-heart-anatomic-overview-and-evaluation-of-pathologic-conditions-with-ct-and-mr-imaging
#6
Farhood Saremi, Damián Sánchez-Quintana, Shumpei Mori, Horia Muresian, Diane E Spicer, Cameron Hassani, Robert H Anderson
The fibrous skeleton is concentrated at the base of the ventricular mass. It provides electrical insulation at the atrioventricular level and fibrous continuity for the leaflets of the mitral, aortic, and tricuspid valves. Its components include the fibrous trigones, the fibrous area of aortic-mitral continuity, the subvalvar collar of the mitral valve, the membranous septum, the interleaflet triangles, the tendon of Todaro, and likely the conus ligament. The majority of the mitral annulus is fibrous, but the only true fibrous part of the tricuspid annulus is where the valvar leaflets are attached to the central fibrous body...
August 18, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28820570/engineering-of-micro-to-nano-structured-3d-printed-drug-releasing-titanium-implants-for-enhanced-osseointegration-and-localized-delivery-of-anticancer-drugs
#7
Shaheer Maher, Gagandeep Kaur, Luis Lima-Marques, Andreas Evdokiou, Dusan Losic
Primary and secondary bone cancers are major causes of pathological bone fractures and their treatment through implant fixation and conventional chemotherapy has many limitations. These implants may suffer from poor osseointegration and their rejection is causing repeated surgery, patient's suffering and extensive expenses. On the other hand, there are severe systemic adverse effects of toxic chemotherapeutics administrated using conventional drug delivery. In this paper to address these two problems we present new type of localized drug-releasing titanium implants with enhanced implants' bio-integration and drug release capabilities that could provide high concentration of toxic anticancer drugs locally to treat bone cancers...
August 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28820418/pathological-adherence-of-placenta-case-reports
#8
R Sulukhia, L Melia, N Pirtskhalava, A Sukhiashvili
Major obstetric hemorrhage is the leading cause of maternal morbidity and mortality. In rare cases, life-threatening hemorrhage in pregnant women may result from abnormal adherence of placenta. Three grades of abnormal placental attachment are defined according to the depth of invasion: placenta accreta, placenta increta, and placenta percreta. An important risk factor for placenta abnormal adherence of placenta is placenta previa in the presence of a uterine scar. The increased prevalence of cesarean section, uterine surgery, and increasing parturient age and parity have led to an increased incidence of abnormal placentation, from one in 2,500 a quarter century ago, to one in 533 deliveries currently...
July 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28820078/effects-of-excitotoxic-lesion-with-inhaled-anesthetics-on-nervous-system-cells-of-rodents
#9
Maria Fernanda Quiroz Padilla, Gemma Guillazo-Blanch, Magdy Sanchez, Maria Andrea Dominguez, Rosa Margaria Gomez
Different anesthesia methods can variably influence excitotoxic lesion effects on the brain. The main purpose of this review is to identify potential differences in the toxicity to nervous system cells of two common inhalation anesthesia methods, isoflurane and sevoflurane, used in combination with an excitotoxic lesion procedure in rodents. The use of bioassays in animal models has provided the opportunity to examine the role of specific molecules and cellular interactions that underlie important aspects of neurotoxic effects relating to calcium homeostasis and apoptosis activation...
August 17, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28819868/one-level-step-section-histological-analysis-is-insufficient-to-confirm-complete-pathological-response-after-neoadjuvant-chemoradiation-for-rectal-cancer
#10
M A Pereira, A R Dias, S F Faraj, C S R Nahas, A R Imperiale, C F S Marques, G C Cotti, B C Camargo, S C Nahas, E S de Mello, U Ribeiro
BACKGROUND: Neoadjuvant chemoradiation therapy (nCRT) for rectal cancer may lead to cure. As we currently lack reliable methods to clinically confirm the absence of disease, some patients undergo radical resection and have pathological complete response (pCR) still undergo surgery. Furthermore, it is uncertain if conventional one-level histopathological analysis is accurate enough to determine complete response. Confirming pCR is essential to determine the prognosis and to consider the patient's inclusion in trials of adjuvant therapy...
August 17, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/28819829/surgical-treatment-for-symptomatic-non-ossifying-fibromas-of-the-lower-extremity-with-calcium-sulfate-grafts-in-skeletally-immature-patients
#11
Antonio Andreacchio, Flavia Alberghina, Gianluca Testa, Federico Canavese
BACKGROUND: Non-ossifying fibromas (NOFs) are common benign bone lesions found in children and adolescents. They usually involve metaphysis of long bones, tend to gradually disappear with age and usually do not require surgery, while they are not associated with pathological fractures. The aim of this study was to evaluate the outcome and efficacy of a single-stage procedure, comprising curettage of the lesion and calcium sulfate pellet (CaSP) grafting, in skeletally immature patients with large, symptomatic NOF of the lower extremity, and the possible limitations of the procedure...
August 17, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28819784/-injuries-of-the-peroneal-tendons-often-overlooked
#12
REVIEW
K Klos, M Knobe, T Randt, P Simons, T Mückley
CLINICAL ISSUE: Injuries of the peroneal tendons are rare and often overlooked. Typical pathologies are tendinitis, tears and dislocation. Accompanying injuries are fractures. They are often associated with instability in the ankle and rearfoot deformities; therefore, these pathologies should be excluded or taken into consideration in the treatment. The clinical examination is crucial for the diagnosis. DIAGNOSTIC WORK-UP: Ultrasound and magnetic resonance imaging (MRI) examinations are very helpful; however, the true extent of the tendon pathology is often first seen during surgery...
August 17, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28819603/bilateral-ankle-fusion-in-leak-syndrome-induced-deformity-a-case-report
#13
Luis Sobral, Ana C Ângelo, Afonso Caetano, Joaquim Rodeia, Isabel Rosa
INTRODUCTION: Systemic capillary leak syndrome (SCLS) is a rare condition of unknown etiology defined by sudden episode of hypotension, high hematocrit, and low serum protein concentration due to capillary hyperpermeability. Several treatments have been published for this pathology and eventual compartment syndrome but not for the disabling consequences. This clinical case highlights the negative orthopedic consequences of a severe systemic attack and reports a subsequent deformity treatment option that resulted in the patient quality of life improvement...
March 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28819577/the-role-of-laparoscopy-in-the-management-of-a-diagnostic-dilemma-jejunal-ectopic-pancreas-developing-into-jejunojejunal-intussusception
#14
Alessio Giordano, Giovanni Alemanno, Carlo Bergamini, Paolo Prosperi, Alessandro Bruscino, Andrea Valeri
Ectopic pancreas (EP) is a rare congenital anomaly defined as the presence of pancreatic tissue in topographic anomaly. It is usually silent but it may become clinically evident when complicated by acute conditions. The development of laparoscopic surgery has changed the way to manage such conditions, especially in the setting of emergency surgery, thanks to its diagnostic and therapeutic role with excellent results. We decided to perform an emergency diagnostic exploratory laparoscopy in a 29-year-old man with an acute abdomen and nonspecific radiological images for intestinal occlusion...
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/28819530/assessment-of-sphenoid-sinus-related-anatomic-variations-with-computed-tomography
#15
Figen Tunalı Turkdogan, Kenan Ahmet Turkdogan, Murat Dogan, Mehmet Haydar Atalar
INTRODUCTION: Frequent and broad application of endoscopic sinus surgery (ESS) in parallel with experience makes it imperative to know the anatomy and the existing pathology very well before surgery. This study examines the association between anomalies in the sphenoid sinus area in paranasal sinuses computed tomography (PNS-CT) and pathological findings and determines variations of sphenoid sinus. METHODS: A total of 200 cases (100 women, 100 men) who had PNS-CT in the emergency and radiology polyclinics within the period of one year were included in this study...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28819506/-parathyroid-carcinoma-about-a-case-and-review-of-the-literature
#16
Naourez Kolsi, Sondos Jellali, Jamel Koubaa
Parathyroid carcinoma is a very rare malignant tumor of the parathyroid gland. Clinically, this cancer is characterized by the presence of severe primary hyperparathyroidism. Diagnosis is based on histological examination but is not always easy. Surgery is the treatment of choice. We report the case of a 59-year old woman with a personal history of arterial hypertension and of recurrent renal lithiasis, presenting with diffuse bone pain associated with asthenia. Neck examination showed hard basi-cervical swelling with nonpalpable lower edge...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28819427/develop-and-validation-a-nomogram-to-predict-the-recurrent-probability-in-patients-with-major-salivary-gland-cancer
#17
Chang-Hsien Lu, Chien-Ting Liu, Pei-Hung Chang, Chia-Yen Hung, Shau-Hsuan Li, Ta-Sen Yeh, Yung-Shin Hung, Wen-Chi Chou
Objectives: Prediction of recurrent risk in patients with major salivary gland carcinoma (MSGC) after surgical treatment is an important but difficult task because of a broad spectrum of tumor histological subtypes and diverse clinical behaviors. This study aimed to develop and validate a nomogram to predict the recurrent probability in patients with MSGC. Methods: A total of 231 consecutive patients with MSGC received curative-intend surgery between 2002 and 2014 from one medical center were selected as the training set...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28819391/a-critical-reappraisal-for-the-value-of-tumor-size-as-a-prognostic-variable-in-rectal-adenocarcinoma
#18
Chien-Hsin Chen, Mao-Chih Hsieh, Ping-Kun Hsiao, En-Kwang Lin, Yen-Jung Lu, Szu-Yuan Wu
Background and Objectives: To investigate critical prognostic factors for local recurrence in patients with rectal adenocarcinoma. Methods: We enrolled 221 consecutive patients who had histologically confirmed adenocarcinoma of the rectum and underwent surgery in our hospital between January 2000 and December 2014. Total mesorectal excision was performed in all patients undergoing a sphincter-sparing procedure or abdominal perineal resection of rectal cancer. To evaluate prognostic factors for local recurrence, we performed univariate and multivariate Cox regression analyses of the local recurrence rate in all patients...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28819007/effects-of-antenatal-melatonin-therapy-on-lung-structure-in-growth-restricted-newborn-lambs
#19
Graeme R Polglase, Jade Barbuto, Beth J Allison, Tamara Yawno, Amy Elizabeth Sutherland, Atul Malhotra, Keith E Schulze, Euan M Wallace, Graham Jenkin, Sharon D Ricardo, Suzanne L Miller
BACKGROUND: Oxidative stress arising from suboptimal placental function contributes to a multitude of pathologies in infants compromised by fetal growth restriction (FGR). FGR infants are at high risk for respiratory dysfunction after birth and poor long-term lung function. OBJECTIVES: To investigate the contribution of oxidative stress to adverse lung development and the effects of melatonin administration, a powerful anti-oxidant, on lung structure in FGR lambs...
August 17, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28818586/a-rare-presentation-of-the-syndrome-of-inappropriate-antidiuretic-hormone-in-a-12-year-old-female-as-the-initial-presentation-of-an-immature-ovarian-teratoma
#20
Anoop Mohamed Iqbal, W Frederick Schwenk
BACKGROUND: Immature ovarian teratoma is very rare in childhood. We are reporting 12 yo female with immature ovarian teratoma who presented initially with syndrome of inappropriate antidiuretic hormone. CASE: A 12 yo female presented with acute abdomen and distention. Initial laboratory tests showed hyponatremia (sodium -123 mmol/L), that did not respond to fluid management. Computerized tomography showed a 15 cm x 9 cm x 20 cm mass in the right ovary with multifocal internal fat, and dystrophic calcifications...
August 14, 2017: Journal of Pediatric and Adolescent Gynecology
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