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https://www.readbyqxmd.com/read/29457724/regio-and-stereoselective-synthesis-of-isoindolin-1-ones-through-buli-mediated-iodoaminocyclization-of-2-1-alkynyl-benzamides
#1
Dhirendra Brahmchari, Akhilesh K Verma, Saurabh Mehta
A simple and straightforward synthesis of isoindolin-1-ones is reported. Exclusive N-cyclization of the amide functional group, an ambident nucleophile, has been accomplished for the cyclization of 2-(1-alkynyl)benzamides using n-BuLi-I2 /ICl. The methodology works with the primary amide and affords the desired isoindolinones in yields of 38-94%. Interestingly, the isolated products exhibit a Z-stereochemistry across the C=C double bond. The reaction mechanism involving the formation of either a vinylic anion or an intimate ion pair intermediate is proposed...
February 19, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29456962/neuroectodermally-derived-neoplasm-of-tonsil-difficulty-in-histomorphological-diagnosis
#2
Albina Venus, Sangita Sharma Mehta
Esthesioneuroblastomas are rare neuroectodermally derived neoplasms occurring in the upper nasal septum or cribriform plate. They have been rarely reported in other sites, when they are called ectopic esthesioneuroblastomas. Due to the scarcity of reports, publications and molecular/genetic studies of these tumours, their diagnosis is likely to be missed when they are ectopic. Similar to the case report in this journal by Zahedi et al., we had a case of neuroectodermally derived neoplasm of the tonsil, which was difficult to diagnose, due to the site of occurrence being unknown for these tumours...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29456364/radiologically-indistinguishable-contiguous-meningioma-and-schwannoma-in-the-same-cerebellopontine-angle-in-a-patient-with-nf2-case-report-and-literature-review
#3
Satyashiva Munjal, Amit Srivastava, Sunila Jain, V S Mehta
No abstract text is available yet for this article.
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29455776/confronting-system-barriers-for-st-elevation-mi-in-low-and-middle-income-countries-with-a-focus-on-india
#4
Sameer Mehta, Christopher Granger, Cindy Lee Grines, Alice Jacobs, Timothy D Henry, Ivan Rokos, Alexandra Lansky, Andreas Baumbach, Roberto Botelho, Alexandra Ferre, Isaac Yepes, Roopa Salwan, Jamshed Dalal, Jitendra Makkar, Neeraj Bhalla, Sundeep Mishra, Vinod Vijan, Shirish Hiremath
Our previous research found seven specific factors that cause system delays in ST-elevation Myocardial infarction management in developing countries. These delays, in conjunction with a lack of organized STEMI systems of care, result in inefficient processes to treat AMI in developing countries. In our present opinion paper, we have specifically explored the three most pertinent causes that afflict the seven specific factors responsible for system delays. In doing so, we incorporated a unique strategy of global STEMI expertise...
January 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29455437/live-donor-liver-transplantation-for-acute-liver-failure-a-single-center-experience
#5
Siddharth Mehrotra, Naimish Mehta, Prashantha S Rao, Shailendra Lalwani, Vivek Mangla, Samiran Nundy
INTRODUCTION: Acute liver failure (ALF) is an indication for emergency liver transplantation (LT). Although centers performing only deceased donor liver transplants (DDLT) have shown improved outcomes in this situation, they still have relatively long waiting lists. An alternative would be living donor liver transplantation (LDLT), which has shown equivalent outcomes in the elective situation but there is limited evidence of its results in ALF. AIM: The purpose of this study was to assess the outcomes in patients with ALF undergoing emergency LDLT in our center in Delhi, India...
February 17, 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/29454922/nutrient-recovery-from-wastewater-through-pilot-scale-electrodialysis
#6
Andrew J Ward, Kimmo Arola, Emma Thompson Brewster, Chirag M Mehta, Damien J Batstone
Nutrient recovery performance utilising an electrodialysis (ED) process was quantified in a 30-cell pair pilot reactor with a 7.2 m2 effective membrane area, utilising domestic anaerobic digester supernatant, which had been passed through a centrifuge as a feed source (centrate). A concentrated product (NH4 -N 7100 ± 300 mg/L and K 2490 ± 40 mg/L) could be achieved by concentrating nutrient ions from the centrate wastewater dilute feed stream to the product stream using the ED process. The average total current efficiency for all major cations over the experimental period was 76 ± 2% (NH4 -N transport 40%, K transport 14%)...
February 8, 2018: Water Research
https://www.readbyqxmd.com/read/29454560/bioactive-lipid-mediators-profiles-in-human-psoriasis-skin-and-blood
#7
Alexander V Sorokin, Anthony Domenichiello, Amit K Dey, Aditya Goyal, Shawn M Rose, Martin P Playford, Christopher E Ramsden, Nehal N Mehta
Psoriasis (PSO) is a chronic immune-mediated disease that represents a unique model for investigating inflammation at local and systemic levels. Bioactive lipid mediators (LM) are potent compounds reported to play a role in the development and resolution of inflammation. Currently, it is not known to what extent these LM are involved in PSO pathophysiology and related metabolic dysfunction. Here we use targeted and untargeted liquid chromatography-tandem mass spectrometry (LC-MS-MS) approaches to quantify LM in skin and peripheral blood from PSO and compared them to those of healthy subjects...
February 15, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29454478/usefulness-of-integrating-heart-failure-risk-factors-into-impairment-of-global-longitudinal-strain-to-predict-anthracycline-related-cardiac-dysfunction
#8
M Wesley Milks, Michael R Velez, Nishaki Mehta, Abiodun Ishola, Thomas Van Houten, Vedat O Yildiz, Raquel Reinbolt, Maryam Lustberg, Sakima A Smith, David A Orsinelli
The prediction of cancer therapeutics-related cardiac dysfunction (CTRCD) is an essential aspect of care for individuals who receive potentially cardiotoxic oncologic treatments. Certain clinical risk factors have been described for incident CTRCD, and measurement of left ventricular (LV) longitudinal strain by speckle tracking 2-dimensional echocardiography (2DE) is the best-validated myocardial mechanical imaging assessment to detect subtle changes in LV function during cancer treatment. However, the direct integration of clinical and imaging risk factors to predict CTRCD has not yet been extensively examined...
January 12, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29454124/brainstem-dose-constraints-in-non-isometric-radiosurgical-treatment-planning-of-trigeminal-neuralgia-a-single-institution-experience
#9
Michael Zhang, Layton A Lamsam, Matthew K Schoen, Swapnil S Mehta, Geoffrey Appelboom, John K Adler, Scott G Soltys, Steven D Chang
INTRODUCTION: CyberKnife stereotactic radiosurgery (SRS) for trigeminal neuralgia (TGN) administers non-isometric, conformational high-dose radiation to the trigeminal nerve with risk of subsequent hypoesthesia. METHODS: We performed a retrospective, single-institution review of 66 TGN patients, treated by CyberKnife, to compare outcomes from two distinct treatment periods (standard dosing, N = 38 and reduced dosing, N = 28). Standard and reduced dosing permitted a maximum brainstem dose of 45 Gy and 25 Gy, respectively, each with a prescription dose of 60 Gy...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29453470/nerve-conduction-and-heart-rate-variability-in-patients-with-hypothyroidism-at-a-tertiary-care-centre-in-eastern-nepal
#10
Shital Gupta, Rita Khadka, Dilip Thakur, Robin Maskey, K D Mehta, B H H Paudel
INTRODUCTION: Thyroid hormone effects on many organs including central and peripheral nervous systems. However, these hormones do not affect all systems/organs to a similar extent. Thus, we conducted this study to explore the effect of thyroid hormones on somatic nervous system assessed by Nerve conduction study and cardiac autonomic activity assessed by heart rate variability. METHODS: The study included newly diagnosed hypothyroid patients and healthy controls...
October 2017: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/29452734/calcar-screw-position-in-proximal-humerus-fracture-fixation-don-t-miss-high
#11
Samir Mehta, Matthew Chin, Jennifer Sanville, Surena Namdari, Michael W Hast
INTRODUCTION: In locked plate fixation of proximal humerus fractures, the calcar is an important anchor point for screws providing much-needed medial column support. Most locking plate implants utilize a fixed-trajectory locking screw to achieve this goal. Consequently, adjustments of plate location to account for patient-specific anatomy may result in a screw position outside of the calcar. To date, little is known about the consequences of "missing" the calcar during plate positioning...
February 11, 2018: Injury
https://www.readbyqxmd.com/read/29452705/the-changing-incidence-and-presentation-of-urinary-stones-over-3-decades
#12
Wonngarm Kittanamongkolchai, Lisa E Vaughan, Felicity T Enders, Tsering Dhondup, Ramila A Mehta, Amy E Krambeck, Cynthia H McCollough, Terri J Vrtiska, John C Lieske, Andrew D Rule
OBJECTIVE: To evaluate trends in the incidence of kidney stones and characteristics associated with changes in the incidence rate over 3 decades. PATIENTS AND METHODS: Adult stone formers in Olmsted County, Minnesota, from January 1, 1984, to December 31, 2012, were validated and characterized by age, sex, stone composition, and imaging modality. The incidence of kidney stones per 100,000 person-years was estimated. Characteristics associated with changes in the incidence rate over time were assessed using Poisson regression models...
February 6, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29452201/the-nasal-microbiome-in-chronic-rhinosinusitis-analyzing-the-effects-of-atopy-and-bacterial-functional-pathways-in-111-patients
#13
Mahboobeh Mahdavinia, Phillip A Engen, Phillip S LoSavio, Ankur Naqib, Rafsa J Khan, Mary C Tobin, Arpita Mehta, Raj Kota, Nailliw Preite, Christopher D Codispoti, Bobby A Tajudeen, Robert P Schleimer, Stefan J Green, Ali Keshavarzian, Pete S Batra
No abstract text is available yet for this article.
February 13, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29450211/-actinotignum-schaalii-infection-a-clandestine-cause-of-sterile-pyuria
#14
Lucy E Horton, Sanjay R Mehta, Lejla Aganovic, Joshua Fierer
Actinotignum schaalii is an underappreciated cause of urinary tract infections (UTIs) in older adults. The diagnosis may be missed due to difficulty isolating and identifying the organism. Complications can result because the organism is intrinsically resistant to 2 commonly used drugs to treat UTI, as illustrated by this case.
February 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29450136/initiative-action-of-tumor-associated-macrophage-during-tumor-metastasis
#15
REVIEW
Saroj Singh, Neesha Mehta, Jiang Lilan, Meen Bahadur Budhthoki, Fu Chao, Li Yong
Tumor-associated macrophages (TAMs) are a significant component of the microenvironment of any solid tumors in the majority of cancers, associated with unfavorable prognosis. TAMs emerge as attractive targets for therapeutic strategies aimed at reprogramming their protumor phenotype into an effective antitumor activity. In this review article, we present an overview of mechanisms responsible for TAMs recruitment and highlight the roles of TAMs in the regulation of tumor angiogenesis, invasion, metastasis, immunosuppression, and chemotherapeutic resistance...
June 2017: Biochimie Open
https://www.readbyqxmd.com/read/29449443/sex-differences-in-ischemic-heart-disease-advances-obstacles-and-next-steps
#16
Niti R Aggarwal, Hena N Patel, Laxmi S Mehta, Rupa M Sanghani, Gina P Lundberg, Sandra J Lewis, Marla A Mendelson, Malissa J Wood, Annabelle S Volgman, Jennifer H Mieres
Evolving knowledge of sex-specific presentations, improved recognition of conventional and novel risk factors, and expanded understanding of the sex-specific pathophysiology of ischemic heart disease have resulted in improved clinical outcomes in women. Yet, ischemic heart disease continues to be the leading cause of morbidity and mortality in women in the United States. The important publication by the Institute of Medicine titled "Women's Health Research-Progress, Pitfalls, and Promise," highlights the persistent disparities in cardiovascular disease burden among subgroups of women, particularly women who are socially disadvantaged because of race, ethnicity, income level, and educational attainment...
February 2018: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29448666/growth-of-large-area-2d-mos%C3%A2-arrays-at-pre-defined-locations-using-stencil-mask-lithography
#17
Intu Sharma, Yogita Batra, V Flauraud, Jürgen Brugger, Bodh Raj Mehta
The growth of MoS2 layers of desired dimensions at predefined locations is essential for fabricating opto-electronic devices based solely on MoS2 or on hetero-structures based on MoS2. Here we present a new route for patterned growth of MoS2 by combining radio frequency (RF) magnetron sputtering, stencil mask lithography and vapour phase sulfurization. The present method does not involve chemical etchants and organic photoresist and hence provides a simplified process of achieving MoS2 patterns. Here, the control over the number of layers (mono, few and bulk) of MoS2 is achieved by varying the thickness of Mo films...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448646/nanoscale-characterization-of-growth-of-secondary-phases-in-off-stoichiometric-czts-thin-films
#18
Manoj Vishwakarma, Olesia M Karakulina, Artem M Abakumov, Joke Hadermann, B R Mehta
The presence of secondary phases is one of the main issues that hinder the growth of pure kesterite Cu2ZnSnS4 (CZTS) based thin films with suitable electronic and junction properties for efficient solar cell devices. In this work, CZTS thin films with varied Zn and Sn content have been prepared by RF-power controlled co-sputtering deposition using Cu, ZnS and SnS targets and a subsequent sulphurization step. Detailed TEM investigations show that the film shows a layered structure with the majority of the top layer being the kesterite phase...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29447737/pulmonary-arterial-hypertension-related-morbidity-is-prognostic-for-mortality
#19
Vallerie V McLaughlin, Marius M Hoeper, Richard N Channick, Kelly M Chin, Marion Delcroix, Sean Gaine, Hossein-Ardeschir Ghofrani, Pavel Jansa, Irene M Lang, Sanjay Mehta, Tomás Pulido, B K S Sastry, Gérald Simonneau, Olivier Sitbon, Rogério Souza, Adam Torbicki, Victor F Tapson, Loïc Perchenet, Ralph Preiss, Pierre Verweij, Lewis J Rubin, Nazzareno Galiè
BACKGROUND: Registry data suggest that disease progression in pulmonary arterial hypertension (PAH) is indicative of poor prognosis. However, the prognostic relevance of PAH-related morbidity has not been formally evaluated in randomized controlled trials. OBJECTIVES: The purpose of these analyses was to assess the impact of morbidity events on the risk of subsequent mortality using the landmark method and data from the SERAPHIN and GRIPHON studies. METHODS: For each study, the risk of all-cause death up to the end of the study was assessed from the landmark time point (months 3, 6, and 12) according to whether a patient had experienced a primary endpoint morbidity event before the landmark...
February 20, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29447318/management-of-multiple-gingival-recessions-with-the-vista-technique-an-18-month-clinical-case-series
#20
Raja Rajeswari S, Tarun Ab Kumar, Triveni M Gowda, Dhoom S Mehta, Arun Kumar
The purpose of the present study was to evaluate the efficacy of the vestibular incision subperiosteal tunnel access (VISTA) technique with collagen membrane, bioactive glass, and platelet-rich fibrin. A total of 22 systemically and periodontally healthy subjects with multiple gingival recession defects (Miller Class I and II) in the maxillary esthetic zone were enrolled in the study. The primary outcome measures were mean root coverage and alteration in gingival thickness. There were no surgical complications; however, one patient reported swelling of the upper lip area on the first postoperative day, which resolved spontaneously...
March 2018: International Journal of Periodontics & Restorative Dentistry
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