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https://www.readbyqxmd.com/read/27905694/high-flow-oxygen-therapy-in-adult-critically-ill-patients
#1
Lorenzo Del Sorbo, Alice Vendramin, Sangeeta Mehta
High flow oxygen therapy is characterized for its ability to meet or exceed the high peak inspiratory flow of the patients with acute respiratory failure. Despite the lack of definitive evidence regarding its efficacy in improving clinically significant outcomes, its application has been rapidly spreading over the last decade. In this review we discuss the potential physiologic mechanisms of benefit as well as the most recent clinical trials investigating its role in adult critically ill patient.
December 1, 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27905120/incidence-of-contralateral-bilateral-nodes-in-the-human-papillomavirus-era
#2
Andrew G Tritter, Vikas Mehta, Madeleine Samuelson, Ginger deGravelle, Xiaohui Ma, Tara Medlin-Moore, Amol Takalkar, Gloria Caldito, Cherie-Ann O Nathan
OBJECTIVES/HYPOTHESIS: HPV-positive oropharyngeal squamous cell carcinoma has a more favorable prognosis when compared to HPV-negative disease, regardless of the presence of nodal metastases. However, the importance of contralateral neck treatment based on HPV status has not been well studied. Given the historically poor prognostic implications of cervical nodal metastases, this study sought to elucidate the relationship between HPV status and contralateral/bilateral nodal metastasis in patients with oropharyngeal squamous cell carcinoma...
December 1, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27905067/mathematical-model-of-bone-remodeling-captures-the-antiresorptive-and-anabolic-actions-of-various-therapies
#3
David S Ross, Khamir Mehta, Antonio Cabal
A better understanding of the molecular pathways regulating the bone remodeling process should help in the development of new antiresorptive regulators and anabolic regulators, that is, regulators of bone resorption and of bone formation. Understanding the mechanisms by which parathyroid hormone (PTH) influences bone formation and how it switches from anabolic to catabolic action is important for treating osteoporosis (Poole and Reeve in Curr Opin Pharmacol 5:612-617, 2005). In this paper we describe a mathematical model of bone remodeling that incorporates, extends, and integrates several models of particular aspects of this biochemical system (Cabal et al...
November 30, 2016: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/27904567/dual-malignancy-in-adolescence-a-rare-case-report-of-metachronous-papillary-carcinoma-of-thyroid-following-dysgerminoma-of-ovary
#4
Suvadip Chakrabarti, Sanjay M Desai, Dharmendra Y Mehta, Shreyas Somanath
Dual malignancy is rare in adolescents. Dual malignancy with the second malignancy of thyroid is rare. No association has been reported between dysgerminoma of ovary and carcinoma thyroid in medical literature. Despite a thorough PubMed search (key words - Papillary carcinoma of thyroid, metachronous, dysgerminoma ovary), we were unable to find a previous reported case of metachronous papillary carcinoma of thyroid (PTC) following dysgerminoma of the ovary. After surgery, the patient is being regularly followed up for recurrence/development of new primary...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27904199/acrofacial-vitiligo-following-halo-formation-around-congenital-melanocytic-naevi
#5
Lalit Kumar Gupta, Chesta Agrawal, Ashok Kumar Khare, Asit Mittal, Sharad Mehta, Manisha Balai
No abstract text is available yet for this article.
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27903890/pharos-collating-protein-information-to-shed-light-on-the-druggable-genome
#6
Dac-Trung Nguyen, Stephen Mathias, Cristian Bologa, Soren Brunak, Nicolas Fernandez, Anna Gaulton, Anne Hersey, Jayme Holmes, Lars Juhl Jensen, Anneli Karlsson, Guixia Liu, Avi Ma'ayan, Geetha Mandava, Subramani Mani, Saurabh Mehta, John Overington, Juhee Patel, Andrew D Rouillard, Stephan Schürer, Timothy Sheils, Anton Simeonov, Larry A Sklar, Noel Southall, Oleg Ursu, Dusica Vidovic, Anna Waller, Jeremy Yang, Ajit Jadhav, Tudor I Oprea, Rajarshi Guha
The 'druggable genome' encompasses several protein families, but only a subset of targets within them have attracted significant research attention and thus have information about them publicly available. The Illuminating the Druggable Genome (IDG) program was initiated in 2014, has the goal of developing experimental techniques and a Knowledge Management Center (KMC) that would collect and organize information about protein targets from four families, representing the most common druggable targets with an emphasis on understudied proteins...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27903659/pulmonary-hypertension-the-importance-of-correctly-diagnosing-the-cause
#7
Sanjay Mehta, Jean-Luc Vachiéry
Pulmonary hypertension (PH) is a complex condition that can occur as a result of a wide range of disorders, including left heart disease, lung disease and chronic pulmonary thromboembolism. Contemporary PH patients are older and frequently have a multitude of comorbidities that may contribute to or simply coincide with their PH. Identifying the cause of PH in these complicated patients can be challenging but is essential, given that the aetiology of the disease has a significant impact on the management options available...
December 2016: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/27902507/smoking-hiv-and-risk-of-pregnancy-loss
#8
Daniel Westreich, Jordan Cates, Mardge Cohen, Kathleen M Weber, Dominika Seidman, Karen Cropsey, Rodney Wright, Joel Milam, Mary A Young, C Christina Mehta, Deborah R Gustafson, Margaret A Fischl, Adaora A Adimora
OBJECTIVE: Cigarette smoking during pregnancy increases risks of poor pregnancy outcomes including miscarriage and stillbirth (pregnancy loss), but the effect of smoking on pregnancy loss among HIV-infected women has not been explored. Here, investigated the impact of smoking on risk of pregnancy loss among HIV-positive and HIV-negative women, and estimated the potential impact of realistic smoking cessation interventions on risk of pregnancy loss among HIV-positive women. DESIGN: We analyzed pregnancy outcomes in HIV-positive and HIV-negative participants in the Women's Interagency HIV Study (WIHS) between 1994 and 2014...
November 29, 2016: AIDS
https://www.readbyqxmd.com/read/27900632/breast-conserving-surgery-alone-for-ductal-carcinoma-in-situ-factors-associated-with-increased-risk-of-local-recurrence
#9
Alessandra Mele, Pritesh Mehta, Priscilla J Slanetz, Alexander Brook, Abram Recht, Ranjna Sharma
PURPOSE: This retrospective study was aimed at identifying clinicopathologic characteristics associated with an increased risk for ipsilateral local recurrence (LR) in patients with ductal carcinoma in situ (DCIS) treated with wide local excision (WLE) alone without radiotherapy (RT). METHODS: All patients with DCIS treated with WLE alone at the Beth Israel Deaconess Medical Center, Boston, MA, USA, between the years 2000 and 2010 were identified. We collected data on demographics, parity, personal or family history of breast cancer, exogenous hormone use, tobacco use, comorbidities, genetic mutation carrier status, imaging interval, and tumor-specific characteristics...
November 29, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27899387/activation-of-cytomegalovirus-corneal-endotheliitis-following-laser-in-situ-keratomileusis
#10
Tien-En Tan, Chui Ming Gemmy Cheung, Jodhbir S Mehta
A case of Cytomegalovirus (CMV) corneal endotheliitis following laser in-situ keratomileusis (LASIK) is presented. A 32-year-old man presented 3 weeks after uncomplicated myopic LASIK with unilateral LASIK flap oedema, interface fluid accumulation, keratic precipitates, anterior uveitis and raised intraocular pressure. Despite treatment with topical corticosteroids, he had 3 further recurrent episodes. Specular microscopy showed decreased endothelial cell density and aqueous humour. Polymerase chain reaction (PCR) testing was positive for CMV DNA...
November 29, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27898621/review-of-targeted-therapies-for-periocular-tumors
#11
Viraj J Mehta, Jeanie Ling, Rachel K Sobel
No abstract text is available yet for this article.
2017: International Ophthalmology Clinics
https://www.readbyqxmd.com/read/27898616/the-role-for-sentinel-lymph-node-biopsy-in-the-management-of-conjunctival-melanoma
#12
Jeanie Ling, Robert Tauscher, Viraj Mehta, Matthew Zhang, Anthony Daniels, Sahar Kohanim
No abstract text is available yet for this article.
2017: International Ophthalmology Clinics
https://www.readbyqxmd.com/read/27897448/diagnostic-ability-of-automated-pupillography-in-glaucoma
#13
Harsha L Rao, Sujatha V Kadambi, Pooja Mehta, Srilakshmi Dasari, Narendra K Puttaiah, Zia S Pradhan, Dhanraj A S Rao, Rohit Shetty
PURPOSE: To evaluate the diagnostic ability of automated pupillography measurements in glaucoma and study the effect of inter-eye asymmetry in glaucomatous damage on the diagnostic ability. METHODS: In an observational, cross-sectional study, 47 glaucoma patients and 42 control subjects underwent automated pupillography using a commercially available device. Diagnostic abilities of the pupillary response measurements were evaluated using area under receiver operating characteristic (ROC) curves (AUC) and sensitivities at fixed specificities...
November 29, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27897000/identifying-cancer-specific-metabolic-signatures-using-constraint-based-models
#14
A Schultz, S Mehta, C W Hu, F W Hoff, T M Horton, S M Kornblau, A A Qutub
Cancer metabolism differs remarkably from the metabolism of healthy surrounding tissues, and it is extremely heterogeneous across cancer types. While these metabolic differences provide promising avenues for cancer treatments, much work remains to be done in understanding how metabolism is rewired in malignant tissues. To that end, constraint-based models provide a powerful computational tool for the study of metabolism at the genome scale. To generate meaningful predictions, however, these generalized human models must first be tailored for specific cell or tissue sub-types...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27896519/image-guidance-technology-and-the-surgical-resection-of-spinal-column-tumors
#15
REVIEW
Bhargav Desai, Jonathan Hobbs, Grant Hartung, Guoren Xu, Ziya L Gokaslan, Andreas Linninger, Ankit I Mehta
Precision imaging is paramount to achieving success in surgical resection of many spinal tumors, whether the goal involves guiding a surgical cure for primary tumors or improving neurological decompression for metastatic lesions. Pre-operatively, image visualization is intimately involved with defining a clear target and surgical planning. Intra-operatively, image-guidance technology allows for surgeons to maximize the probability for gross total resection of spinal cord tumors and minimize damage to adjacent structures...
November 28, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27896510/standard-clinical-protocol-for-bidirectional-hyperthermic-intraperitoneal-chemotherapy-hipec-systemic-leucovorin-5-fluorouracil-and-heated-intraperitoneal-oxaliplatin-in-a-chloride-containing-carrier-solution
#16
Akash M Mehta, Alwin D R Huitema, Jacobus W A Burger, Alexandra R M Brandt-Kerkhof, Sander F van den Heuvel, Victor J Verwaal
BACKGROUND: Intraperitoneal chemotherapy has an established role in the treatment of selected patients with colorectal peritoneal metastases. Oxaliplatin is highly suitable as a chemotherapeutic agent for hyperthermic intraperitoneal chemotherapy (HIPEC), but its use to date has been limited because of the morbidity caused by severe electrolyte and glycemic imbalances associated with 5% glucose as its carrier solution. This report provides an overview of the development, rationale, and application of intraperitoneal chemotherapy and the use of various drugs and carrier solutions...
November 28, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27894796/cognitive-challenges-aging-and-neuromuscular-fatigue
#17
Ashley E Shortz, Ranjana K Mehta
Cognitive challenges, such as concurrent cognitive demands or prior cognitive fatigue, have shown to adversely impact neuromuscular fatigue, specifically in younger adults. Whether these relationships are similar for the aging population remains unclear. The aim of the study was to investigate the effects of different cognitive challenges on handgrip fatigue with aging. Ten younger (24.10 (1.79) years) and ten older (75.90 (7.80) years) females attended three experimental conditions (control, i.e., exercise only, cognitive fatigue prior to exercise, and concurrent mental arithmetic during exercise) on different days...
November 25, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27894147/reliability-concurrent-validity-and-minimal-detectable-change-for-iphone-goniometer-app-in-assessing-knee-range-of-motion
#18
Saurabh P Mehta, Katherine Barker, Brett Bowman, Heather Galloway, Nicole Oliashirazi, Ali Oliashirazi
Much of the published works assessing the reliability of smartphone goniometer apps (SG) have poor generalizability since the reliability was assessed in healthy subjects. No research has established the values for standard error of measurement (SEM) or minimal detectable change (MDC) which have greater clinical utility to contextualize the range of motion (ROM) assessed using the SG. This research examined the test-retest reproducibility, concurrent validity, SEM, and MDC values for the iPhone goniometer app (i-Goni; June Software Inc...
November 28, 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/27893866/ecology-and-demography-of-free-roaming-domestic-dogs-in-rural-villages-near-serengeti-national-park-in-tanzania
#19
Anna M Czupryna, Joel S Brown, Machunde A Bigambo, Christopher J Whelan, Supriya D Mehta, Rachel M Santymire, Felix J Lankester, Lisa J Faust
Free-roaming dogs (Canis lupus familiaris) are of public health and conservation concern because of their potential to transmit diseases, such as rabies, to both people and wildlife. Understanding domestic dog population dynamics and how they could potentially be impacted by interventions, such as rabies vaccination, is vital for such disease control efforts. For four years, we measured demographic data on 2,649 free-roaming domestic dogs in four rural villages in Tanzania: two villages with and two without a rabies vaccination campaign...
2016: PloS One
https://www.readbyqxmd.com/read/27893327/radiation-therapy-for-glioblastoma-american-society-of-clinical-oncology-clinical-practice-guideline-endorsement-of-the-american-society-for-radiation-oncology-guideline
#20
Erik P Sulman, Nofisat Ismaila, Terri S Armstrong, Christina Tsien, Tracy T Batchelor, Tim Cloughesy, Evanthia Galanis, Mark Gilbert, Vinai Gondi, Mary Lovely, Minesh Mehta, Matthew P Mumber, Andrew Sloan, Susan M Chang
Purpose The American Society for Radiation Oncology (ASTRO) produced an evidence-based guideline on radiation therapy for glioblastoma. Because of its relevance to the ASCO membership, ASCO reviewed the guideline and applied a set of procedures and policies used to critically examine guidelines developed by other organizations. Methods The ASTRO guideline on radiation therapy for glioblastoma was reviewed for developmental rigor by methodologists. An ASCO endorsement panel updated the literature search and reviewed the content and recommendations...
November 28, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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