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https://www.readbyqxmd.com/read/27907962/critical-care-of-traumatic-cervical-spinal-cord-injuries-preventing-secondary-injury
#1
Gary Schwartzbauer, Deborah Stein
The incidence of traumatic spinal cord injury (SCI) has not changed much over the years due to an aging population suffering falls, yet advances have been made in quality of life and survival time. In addition to initial medical and surgical stabilization, modern intensive care unit (ICU) care throughout the critical early period following SCI is essential to avoid continued secondary injury to the spinal cord. Cervical SCI patients are particularly prone and sensitive to periods of cardiovascular instability and respiratory failure directly resulting from their injuries...
December 2016: Seminars in Neurology
https://www.readbyqxmd.com/read/27907960/multimodality-monitoring-illuminating-the-comatose-human-brain
#2
Charles L Francoeur, Margaret Pain, Stephan A Mayer
The field of neurocritical care has evolved tremendously in recent years, a development explained vastly by the advent of neurophysiological monitoring. From basic intracranial pressure measurements to brain tissue oxygenation, microdialysis, cerebral blood flow (CBF), and surface and intracortical electroencephalography (EEG), our ability to detect and control physiologic endpoints of brain function in comatose patients has grown substantially. The integration of these data gave birth to the concept of multimodality monitoring (MMM)...
December 2016: Seminars in Neurology
https://www.readbyqxmd.com/read/27900774/paclitaxel-inhibits-post-traumatic-recurrent-laryngeal-nerve-regeneration-into-the-posterior-cricoarytenoid-muscle-in-a-canine-model
#3
Andrea M Park, Neel K Bhatt, Randal C Paniello
OBJECTIVES/HYPOTHESIS: To investigate the efficacy of paclitaxel, a potent microtubule inhibitor with a more favorable therapeutic index as compared with vincristine, in preventing post-traumatic nerve regeneration of the recurrent laryngeal nerve into the posterior cricoarytenoid muscle in a canine laryngeal model. STUDY DESIGN: Experimental animal study. METHODS: Forty-nine canine hemilaryngeal specimens were divided into five experimental groups...
November 30, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27897463/a-qualitative-analysis-of-factors-related-to-eating-disorder-onset-in-female-collegiate-athletes-and-non-athletes
#4
Jessyca Arthur-Cameselle, Kayla Sossin, Paula Quatromoni
Female athletes are at risk for clinical eating disorders, yet their onset experiences have rarely been studied with qualitative methods. This study, which included interviews with 12 collegiate female athletes and 17 non-athletes, identified factors that contributed to eating disorder onset for both subgroups. Inductive content analysis revealed that low self-worth, peer issues, and comorbid psychological disorders were common in both groups. However, athletes reported sport-specific factors including performance pressure, team weigh-ins, and injuries, whereas family dysfunction, bullying, and puberty were more commonly reported triggers for non-athletes...
November 29, 2016: Eating Disorders
https://www.readbyqxmd.com/read/27897187/a-latent-structural-equation-model-of-protective-behaviors-and-pressure-ulcer-outcomes-among-people-living-with-spinal-cord-injury
#5
C Li, N D DiPiro, J Krause
STUDY DESIGN: Cross-sectional. OBJECTIVE: To develop a latent structural model to demonstrate the relationship between factor structures of protective health behaviors and pressure ulcer (PrU) outcomes among participants with spinal cord injury (SCI). SETTING: Data were collected at a large specialty hospital and analyzed at a medical university in the Southeastern USA. METHODS: A total of 1871 participants with traumatic SCI of at least 1 year duration were included...
November 29, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27893566/validity-and-reliability-of-a-portable-balance-tracking-system-btracks-in-older-adults
#6
Susan S Levy, Katie J Thralls, Shiloah A Kviatkovsky
BACKGROUND AND PURPOSE: Falls are the leading cause of disability, injury, hospital admission, and injury-related death among older adults. Balance limitations have consistently been identified as predictors of falls and increased fall risk. Field measures of balance are limited by issues of subjectivity, ceiling effects, and low sensitivity to change. The gold standard for measuring balance is the force plate; however, its field use is untenable due to high cost and lack of portability...
November 23, 2016: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/27890062/a-nurse-initiated-perioperative-pressure-injury-risk-assessment-and-prevention-protocol
#7
Anita J Meehan, Nancy R Beinlich, Tracy L Hammonds
Pressure injuries negatively affect patients physically, emotionally, and economically. Studies report that pressure injuries occur in 69% of inpatients who have undergone a surgical procedure while hospitalized. In 2012, we created a nurse-initiated, perioperative pressure injury risk assessment measure for our midwestern, urban, adult teaching hospital. We retrospectively applied the risk assessment to a random sample of 350 surgical patients which validated the measure. The prospective use of the risk assessment and prevention measures in 350 surgical patients resulted in a 60% reduction in pressure injuries compared with the retrospective group...
December 2016: AORN Journal
https://www.readbyqxmd.com/read/27884430/strengthening-of-c2c12-mouse-myoblasts-against-compression-damage-by-mild-cyclic-compressive-stimulation
#8
Yifei Yao, Arthur Ft Mak
Deep tissue injury (DTI) is a severe kind of pressure ulcers formed by sustained deformation of muscle tissues over bony prominences. As a major clinical issue, DTI affects people with physical disabilities, and is obviously related to the load-bearing capacity of muscle cells in various in-vivo conditions. It is important to provide a preventive approach to help muscle cells from being damaged by compressive stress. In this study, we hypothesized that cyclic compressive stimulation could strengthen muscle cells against compressive damage and enhance the cell plasma membrane resealing capability...
November 16, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27881405/effectiveness-of-individualised-lung-recruitment-strategies-at-birth-an-experimental-study-in-preterm-lambs
#9
David G Tingay, Anushi E Rajapaksa, Emanuela Zannin, Prue M Pereira-Fantini, Raffaele Dellacà, Elizabeth Perkins, Cornelis Elroy E Zonneveld, Andy Adler, Don Black, Inez Frerichs, Anna Lavizzari, Magdy Sourial, Bartłomiej Grychtol, Fabio Mosca, Peter G Davis
Respiratory transition at birth involves rapidly clearing fetal lung liquid and preventing efflux back into the lung whilst aeration is established. We have developed a sustained inflation (SIOPT) individualized to volume-response and a dynamic tidal positive end-expiratory pressure (open lung volume, OLV) strategy that both enhance this process. We aimed to compare the effect of each with a group managed with PEEP of 8 cmH2O and no recruitment manoeuvre (No-RM), on gas exchange, lung mechanics, spatiotemporal aeration and lung injury in 127±1d preterm lambs...
November 23, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27881386/ppar%C3%AE-augments-heart-function-and-cardiac-fatty-acid-oxidation-in-early-experimental-polymicrobial-sepsis
#10
Stephen Wade Standage, Brock G Bennion, Taft Olpin Knowles, Dolena R Ledee, Michael A Portman, John K McGuire, W Conrad Liles, Aaron K Olson
Children with sepsis and multisystem organ failure have downregulated leukocyte gene expression of PPARα, a nuclear hormone receptor transcription factor that regulates inflammation and lipid metabolism. Mouse models of sepsis have likewise demonstrated that the absence of PPARα is associated with decreased survival and organ injury, specifically of the heart. Using a clinically relevant mouse model of early sepsis, we found that heart function increases in wild type (WT) mice over the first 24 hours of sepsis, but that mice lacking PPARα (Ppara(-/-)) cannot sustain the elevated heart function necessary to compensate for sepsis pathophysiology...
November 23, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27878785/lesions-requiring-wound-management-in-a-central-tertiary-neonatal-intensive-care-unit
#11
Angéla Meszes, Gyula Tálosi, Krisztina Máder, Hajnalka Orvos, Lajos Kemény, Zsanett Renáta Csoma
BACKGROUND: Most of the skin disorders that occur in neonatal intensive care units are due in part to the immaturity and vulnerability of the neonatal skin. Various iatrogenic diagnostic and therapeutic procedures are also conducive to iatrogenic damage. This study was to review the neonates admitted to our neonatal intensive care unit who needed wound management, and to assess the most common skin injuries and wounds, and their aetiology. METHODS: Data were extracted from medical records of neonates who needed wound management in our Neonatal Intensive Care Unit between January 31, 2012 and January 31, 2013...
November 23, 2016: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/27875900/effects-of-necrostatin-1-an-inhibitor-of-necroptosis-and-its-inactive-analogue-nec-1i-on-basal-cardiovascular-function
#12
A Szobi, T Rajtik, A Adameova
Inhibition of receptor-interacting serine/threonine-protein kinase 1 (RIP1) by necrostatin-1 (Nec-1) alleviates cardiac injury due to prevention of necroptotic cell death. Its inactive analogue necrostatin-1i (Nec-1i), lacking RIP1 activity, serves as a suitable control. It is unknown if these agents influence the heart function in the absence of damaging stimuli. For this purpose, we measured intraarterial blood pressure (systolic - sBP and diastolic - dBP) and ECG parameters after a bolus administration of Nec-1 and Nec-1i in rats during 30 min...
November 23, 2016: Physiological Research
https://www.readbyqxmd.com/read/27874107/the-effect-of-oral-consumption-of-probiotics-in-prevention-of-heart-injury-in-a-rat-myocardial-infarction-model-a-histopathological-hemodynamic-and-biochemical-evaluation
#13
Jafar Sadeghzadeh, Abedin Vakili, Hamid Reza Sameni, Mahdi Shadnoush, Ahmad-Reza Bandegi, Mahdi Zahedi Khorasani
BACKGROUND: Despite the emerging evidence on beneficial effects of probiotics on the cardiovascular system, their impact on the management of ischemic heart diseases and its possible mechanism have not been elucidated. METHODS: Four viable probiotics bacterial strains, including Bifidobacterium breve, Lactobacillus casei, Lactobacillus bulgaricus and Lactobacillus acidophilus, at the concentrations of 2×106 colony-forming units/ml were orally administered to the rats daily for 14 days before the induction of infarct-like myocardial injury using isoproterenol...
November 22, 2016: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27866543/-influence-of-coke-oven-emissions-on-workers-blood-pressure-and-electrocardiographic-findings
#14
J J Liang, G L Yi, G S Mao, D M Wang, X Y Dai
Objective: To investigate the influence of coke oven emissions on workers' blood pressure and electrocardiographic findings, and to provide a basis for the prevention and treatment of cardiovascular diseases. Methods: The concentration of coke oven emissions at the bottom, side, and top of coke ovens was determined in a coking plant. A total of 406 coke oven workers were enrolled as exposure group and 201 office staff members were enrolled as control group. Blood pressure and electrocardiographic findings were compared between the two groups, and the multivariate logistic regression analysis was performed to analyze the influencing factors for hypertension and abnormal electrocardiographic findings...
September 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27865481/the-influence-of-tethering-and-gravity-on-the-stability-of-compliant-liquid-lined-airways
#15
Jeremy Whang, Chandler Faulman, Thomas A Itin, Donald P Gaver
This study revolves around two simple questions: 1) how does pulmonary airway recruitment/de-recruitment (RecDer) depend on the tethering support provided by surrounding airways and alveoli, and 2) does airway angle of inclination (θ) influence airway stability? These two questions are critical to understanding the existence and prevention of atelectrauma, which may contribute to ventilator-induced lung injury (VILI). To address these questions, we develop PDMS 2mm ID compliant tubes that mimic pulmonary airways...
November 11, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27864828/maternal-na-intake-induces-renal-function-injury-in-rats-prevented-by-a-short-term-angiotensin-converting-enzyme-inhibitor
#16
Natalie E Ribeiro, E V Cabral, Regina S Aires, Leucio D Vieira-Filho, Valdilene S Ribeiro, Daianna R M Gonçalves, Luis P N C Borges, Ismaela M F Melo, Cintia G M Ferreira, Valeria Wanderley-Teixeira, Álvaro A C Teixeira, Anísio F Soares, Ana D O Paixão
The Na(+) -ATPase, a secondary pump in the proximal tubule, is only weakly responsive to angiotensin II in adult offspring exposed perinatally to high Na(+) intake. We have investigated whether the offspring from mothers given 0.3 M NaCl show an ineffective angiotensin II action to increase in blood pressure. It was hypothesized that functional alterations at adult life are associated with the number angiotensin II-positive cells in the developing kidney, with increased oxidative stress in maternal/foetal organs, or with morphometrical changes in placentas...
November 19, 2016: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/27863592/nursing-interventions-in-stroke-care-delivery-an-evidence-based-clinical-review
#17
Dimitrios Theofanidis, Bernard Gibbon
INTRODUCTION: Generally, nursing interventions during the acute stages following a stroke aim at preventing secondary brain injury (intracranial hypertension), maintaining the airways (due to paralysis of the pharynx muscles), providing general body support (vital signs, fluid and electrolyte balance), and anticipating the occurrence of complications (atelectasis and pneumonia). AIM: This literature review is to prioritize nursing interventions for acute stroke and to update nursing roles and input considering recommended levels of evidence of care to date...
December 2016: Journal of Vascular Nursing: Official Publication of the Society for Peripheral Vascular Nursing
https://www.readbyqxmd.com/read/27861175/transient-receptor-potential-vanilloid-4-and-serum-glucocorticoid-regulated-kinase-1-are-critical-mediators-of-lung-injury-in-overventilated-mice-in-vivo
#18
Laura Michalick, Lasti Erfinanda, Ulrike Weichelt, Markus van der Giet, Wolfgang Liedtke, Wolfgang M Kuebler
BACKGROUND: Mechanical ventilation can cause lung endothelial barrier failure and inflammation cumulating in ventilator-induced lung injury. Yet, underlying mechanotransduction mechanisms remain unclear. Here, the authors tested the hypothesis that activation of the mechanosensitive Ca channel transient receptor potential vanilloid (TRPV4) by serum glucocorticoid-regulated kinase (SGK) 1 may drive the development of ventilator-induced lung injury. METHODS: Mice (total n = 54) were ventilated for 2 h with low (7 ml/kg) or high (20 ml/kg) tidal volumes and assessed for signs of ventilator-induced lung injury...
November 18, 2016: Anesthesiology
https://www.readbyqxmd.com/read/27857494/osteofascial-compartment-pressure-measurement-in-closed-limb-injuries-whitesides-technique-revisited
#19
Rajendra Kumar Beniwal, Abhishek Bansal
INTRODUCTION: Regular monitoring of tissue compartmental pressures and hence a timely intervention in patients with impending compartment syndrome has been shown to prevent morbidity and permanent disability. MATERIAL AND METHODS: Intra-compartmental pressure in flexor compartment of forearm and various compartments of legs following recent trauma presenting within 6 h of injury was carried out in 30 subjects using Whitesides' technique and patients were classified into 3 categories for treatment purposes i...
October 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/27849772/128-modeling-to-individualize-mean-arterial-pressure-threshold-to-prevent-acute-kidney-injury-in-the-icu
#20
Ricardo Pacheco, Cátia Salgado, Rodrigo Deliberato, Leo Anthony Celi, João Sousa, Susana Vieira
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
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