keyword
MENU ▼
Read by QxMD icon Read
search

meningoencephalitis

keyword
https://www.readbyqxmd.com/read/28548945/soluble-antigens-from-the-neurotropic-pathogen-angiostrongylus-cantonensis-directly-induce-thymus-atrophy-in-a-mouse-model
#1
Zhen Liu, Dong-Ming Su, Zi-Long Yu, Feng Wu, Rui-Feng Liu, Shi-Qi Luo, Zhi-Yue Lv, Xin Zeng, Xi Sun, Zhong-Dao Wu
The nematode Angiostrongylus cantonensis (A.C.) is a neurotropic pathogen; stage-III larva invade the human (non-permissive host) central nervous system (CNS) to cause eosinophilic meningitis or meningoencephalitis accompanied by immunosuppression. In an A.C.-infectedmouse (another non-permissive host) model, CNS damage-associated T cell immune deficiency and severe inflammation were proposed to result from activation of the hypothalamic-pituitary-adrenal (HPA) axis. However, glucocorticoids are anti-inflammatory agents...
May 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28545897/resveratrol-relieves-angiostrongylus-cantonensis-induced-meningoencephalitis-by-activating-sirtuin-1
#2
An-Chih Chen, Ling-Yuh Shyu, Yue-Loong Hsin, Ke-Min Chen, Shih-Chan Lai
Resveratrol, a natural herbal compound found in high levels in grapes and red wine, is frequently used as activator of sirtuin-1. This study investigated the potential function of sirtuin-1 in regulating angiostrongyliasis meningoencephalitis in resveratrol-treated mice. Mice were subjected to meningoencephalitis to study the protective effect of resveratrol against meningoencephalitis and investigate the effects of sirtuin-1 activation on brain. Results demonstrated that sirtuin-1 level decreased in mice with meningoencephalitis and significantly increased in resveratrol-treated mice...
May 22, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28536555/novel-antifungal-activity-for-the-lectin-scytovirin-inhibition-of-cryptococcus-neoformans-and-cryptococcus-gattii
#3
Tyler H Jones, Erin E McClelland, Hana McFeeters, Robert L McFeeters
Pathogenic cryptococci are encapsulated yeast that can cause severe meningoencephalitis. Existing therapeutic options are dated and there is a growing need for new alternative antifungal agents for these fungi. Here we report novel inhibition of pathogenic cryptococci by the antimicrobial lectin Scytovirin. Inhibition was most potent against Cryptococcus neoformans var neoformans and C. gattii, with MFC values of 500 nM. Scytovirin binding was localized to the cell wall and shown to affect capsule size and release...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28536430/aetiology-of-acute-meningoencephalitis-in-cambodian-children-2010-2013
#4
Paul F Horwood, Veasna Duong, Denis Laurent, Channa Mey, Heng Sothy, Ky Santy, Beat Richner, Seiha Heng, Sopheak Hem, Justine Cheval, Christopher Gorman, Philippe Dussart, Menno D de Jong, Alexandra Kerleguer, Bertrand Guillard, Bernadette Murgue, Marc Lecuit, Xavier de Lamballerie, Jeremy J Farrar, Arnaud Tarantola, Marc Eloit, Philippe Buchy
Acute meningoencephalitis (AME) is associated with considerable morbidity and mortality in children in developing countries. Clinical specimens were collected from children presenting with AME at two Cambodian paediatric hospitals to determine the major aetiologies associated with AME in the country. Cerebrospinal fluid (CSF) and blood samples were screened by molecular and cell culture methods for a range of pathogens previously associated with AME in the region. CSF and serum (acute and convalescent) were screened for antibodies to arboviruses such as Japanese encephalitis virus (JEV), dengue virus (DENV), and chikungunya virus (CHIKV)...
May 24, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28532804/mycobacterium-avium-subsp-hominissuis-menigoencephalitis-in-a-cat
#5
Hiroo Madarame, Miyoko Saito, Kikumi Ogihara, Hideharu Ochiai, Mami Oba, Tsutomu Omatsu, Yuzo Tsuyuki, Tetsuya Mizutani
A 33-month old, neutered female Abyssinian cat died. The cat had sudden onset of widespread neurologic signs about half a year after birth. Mycobacterium avium subsp. hominissuis (MAH) group was isolated and identified from the brain of a cat affected with pyogranulomatous meningoencephalitis. The central nervous system (CNS) was involved in the disseminated MAH infection. MAH infection should be considered in cats with neurologic signs in regard to zoonotic aspects. Comparatively, this is a first case of MAH infection observed in the brain in either humans or animals...
May 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28531943/recent-trends-in-zikv-research-a-step-away-from-cure
#6
REVIEW
Aftab Alam, Nikhat Imam, Anam Farooqui, Shahnawaz Ali, Md Zubbair Malik, Romana Ishrat
Zika virus (ZikV) is a member of the Flaviviridae virus family, genus Flavivirus has emerged as a potential threat to human health worldwide. Consequences of vertical infections includes microcephaly with brain and eye anomalies, and adult infections includes Guillain-Barrésyndrome (GBS), brain ischemia, myelitis and meningoencephalitis. To develop a better treatment, many efforts are being made, like drug-repurposing concept for FDA-approved drugs for antiviral activity are screened against ZikV infection and emerging as a promising alternative to expedite drug development and various vaccines like DNA, ZPIV, LAIV, mRNA and AGS-v vaccines have been designed and in under clinical trial phases...
May 17, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28529273/septicemic-invasive-klebsiella-pneumoniae-infection-in-a-cynomolgus-monkey-macaca-fascicularis-with-severe-diffused-suppurative-meningoencephalitis
#7
Kazufumi Kasuya, Kou Takayama, Makiko Bito, Natsumi Shimokubo, Ryosuke Kawashima, Tomoyuki Shibahara
A 2-year-old male cynomolgus monkey (Macaca fascicularis) showed neurological symptoms during quarantine for importation into Japan, and was euthanized due to poor prognosis. Gross anatomical examination revealed a hemorrhagic lesion around the lateral ventricle in the cerebrum. Histologically, severe diffused suppurative meningitis and ventriculitis were detected with numerous Gram-negative bacilli in the cerebrum. Immunohistochemically, the bacilli were positively stained with an antibody against Klebsiella pneumoniae...
May 22, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28511987/human-parechovirus-type-3-infection-an-emerging-infection-in-neonates-and-young-infants
#8
REVIEW
Yuta Aizawa, Ryohei Izumita, Akihiko Saitoh
Human parechoviruses (HPeVs) are RNA viruses that have characteristics similar to those of enteroviruses and usually cause mild respiratory or gastrointestinal symptoms. Human parechovirus type 3 (HPeV3), first reported in 2004, is exceptional because it can provoke sepsis and meningoencephalitis leading to neurological sequelae, and even death, in neonates and young infants. Pediatricians and researchers are increasingly aware that HPeV3 is responsible for serious disease in neonates and young infants. Retrospective studies and several reports of epidemics of HPeV3 infection have provided data on epidemiology, clinical symptoms and signs, laboratory findings, and outcomes...
May 13, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28482001/crimean-congo-hemorrhagic-fever-in-humanized-mice-reveals-glial-cells-as-primary-targets-of-neurological-infection
#9
Jessica R Spengler, M Kelly Keating, Anita K McElroy, Marko Zivcec, JoAnn D Coleman-McCray, Jessica R Harmon, Brigid C Bollweg, Cynthia S Goldsmith, Éric Bergeron, James G Keck, Sherif R Zaki, Stuart T Nichol, Christina F Spiropoulou
Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral hemorrhagic disease seen exclusively in humans. Central nervous system (CNS) infection and neurological involvement have also been reported in CCHF. Here we inoculated NSGTM-SGM3 mice engrafted with human hematopoietic CD34+ stem cells with low passage CCHF virus strains isolated from human patients. Humanized mice develop lethal disease characterized by histopathological change in the liver and brain. To date, targets of neuroinfection and neuropathology have not been investigated in CCHF...
May 8, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28480282/pediatric-drug-nitazoxanide-a-potential-choice-for-control-of-zika
#10
Rui-Yuan Cao, Yong-Fen Xu, Tian-Hong Zhang, Jing-Jing Yang, Ye Yuan, Pei Hao, Yi Shi, Jin Zhong, Wu Zhong
Zika virus (ZIKV) infection can be the cause of congenital malformations, including microcephaly in infants and can cause other disorders such as Guillain-Barré syndrome, meningoencephalitis, and myelitis, which can also occur in some infected adults. However, at this time, there is no drug approved to treat ZIKV infection. Drug repurposing is the promptest way to obtain an effective drug during a global public health emergency such as the spread of Zika virus. In this study, we report a US Food and Drug Admistration-approved drug that is safe for pediatric use...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28475781/2015-epidemic-of-severe-streptococcus-agalactiae-sequence-type-283-infections-in-singapore-associated-with-the-consumption-of-raw-freshwater-fish-a-detailed-analysis-of-clinical-epidemiological-and-bacterial-sequencing-data
#11
Shirin Kalimuddin, Swaine L Chen, Cindy T K Lim, Tse Hsien Koh, Thean Yen Tan, Michelle Kam, Christopher W Wong, Kurosh S Mehershahi, Man Ling Chau, Lee Ching Ng, Wen Ying Tang, Hishamuddin Badaruddin, Jeanette Teo, Anucha Apisarnthanarak, Nuntra Suwantarat, Margaret Ip, Matthew T G Holden, Li Yang Hsu, Timothy Barkham
Background: Streptococcus agalactiae (group B Streptococcus [GBS]) has not been described as a foodborne pathogen. However, in 2015, a large outbreak of severe invasive sequence type (ST) 283 GBS infections in adults epidemiologically linked to the consumption of raw freshwater fish occurred in Singapore. We attempted to determine the scale of the outbreak, define the clinical spectrum of disease, and link the outbreak to contaminated fish. Methods: Time-series analysis was performed on microbiology laboratory data...
May 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28473359/pasteurella-multocida-meningoencephalitis-in-an-immunocompetent-adult-with-multiple-cat-scratches
#12
David Alistair Clarke, Angela Mcbride, Michael Kelsey, Ben Killingley
We present the case of a 49-year-old woman admitted to our Acute Medical Unit with a 2-day history of fever, vomiting and confusion. The patient was alcohol dependent and had sustained several scratches from her pet cat, which her pet dog had licked. She deteriorated in the Emergency Department-developing high fever, worsening confusion and meningism. Blood cultures were taken and broad spectrum antibiotics commenced prior to CT scanning and diagnostic lumbar puncture. Blood cultures and CSF 16S ribosomal PCR confirmed a diagnosis of Pasteurella multocida bacteraemia and meningoencephalitis...
May 3, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28459170/clinical-features-and-neurologic-complications-of-children-hospitalized-with-chikungunya-virus-in-honduras
#13
José A Samra, Nancy L Hagood, Andrea Summer, Marco T Medina, Kenton R Holden
The first case of Chikungunya virus in Honduras was identified in 2014. The virus has spread widely across Honduras via the Aedes aegypti mosquito, leading to an outbreak of Chikungunya virus (CHIKV) in 2015 that significantly impacted children. A retrospective chart review of 235 children diagnosed with CHIKV and admitted to the National Autonomous University of Honduras Hospital Escuela (Hospital Escuela) in Tegucigalpa, Honduras, was accomplished with patients who were assessed for clinical features and neurologic complications...
January 1, 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28458823/herpes-simplex-virus-type-1-encephalitis-in-an-adolescent-presenting-with-acute-hydrocephalus
#14
Marios S Themistocleous, Elias Antoniades, Dimitrios Giakoumettis, Aristoteles V Kalyvas, Andreas Mitsios, George Sfakianos
Herpes simplex virus Type 1 (HSV-1) is a human neurotropic virus causing encephalitis, corneal blindness or several peripheral nervous system disorders. Herpes Simplex encephalitis (HSE) is the most devastating clinical syndrome with severe morbidity and mortality. Hydrocephalus associated with viral meningoencephalitis is an extremely rare entity with only few documented cases, predominantly due to HSV-2 infection. HSV-1 infection of central nervous system present in the majority of the cases as encephalitis...
February 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28452107/neuroinvasive-st-louis-encephalitis-virus-infection-in-solid-organ-transplant-recipients
#15
Carlos A Hartmann, Holenarasipur R Vikram, Maria T Seville, Robert Orenstein, Shimon Kusne, Janis E Blair, Thomas E Grys, Roberto L Patron
In the summer of 2015, 3 unrelated solid organ transplant recipients had meningoencephalitis suggestive of West Nile virus (WNV) infection in Phoenix, Arizona. Testing was inconclusive but was later confirmed as St. Louis encephalitis (SLE). We retrospectively reviewed clinical manifestations, treatment, and outcomes of these transplant recipients. Common symptoms were fever, rigors, diarrhea, headache, and confusion. One patient died 3 days after hospitalization. Therapy for the 2 patients was initiated with interferon alfa-2b (IFN) and intravenous immunoglobulin G (IVIG) (IFN+IVIG in combination)...
April 27, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28451778/central-nervous-system-melioidosis-in-the-pediatric-age-group-review
#16
REVIEW
G Lakshmi Prasad, Pushpa Kini, Divya S
PURPOSE: Melioidosis is a potentially fatal infectious disease caused by Burkholderia pseudomallei. Neurologic involvement in pediatric age group is very rare, and only a handful of cases have been reported in literature. We sought to provide a systematic review of pediatric neurologic melioidosis. METHODS: Literature review was performed to analyze reported cases of pediatric neurologic melioidosis (≤16 years) by searching online database (PubMed/MEDLINE). RESULTS: Twenty-seven cases were analyzed...
April 27, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28450174/atorvastatin-as-a-promising-anticryptococcal-agent
#17
Noelly de Queiroz Ribeiro, Marliete Carvalho Costa, Thaís Furtado Ferreira Magalhães, Hellem Cristina Silva Carneiro, Lorena Vívien Oliveira, Alide Caroline Lima Fontes, Julliana Ribeiro Alves Santos, Gabriela Freitas Ferreira, Glauber Ribeiro de Sousa Araujo, Vinícius Alves, Susana Frases, Tatiane Alves Paixão, Maria Aparecida de Resende Stoianoff, Daniel Assis Santos
Cryptococcosis caused by Cryptococcus gattii leads to pneumonia and meningoencephalitis, and has a high mortality rate worldwide due to the inadequacy of available therapy and increasing drug resistance. There is a need to develop effective treatments, and drug repositioning is an interesting alternative to achieve new strategies to treat cryptococcosis. Atorvastatin (ATO), a statin currently used to treat hypercholesterolaemia, was tested in this study as an adjuvant to control infections caused by C. gattii...
June 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28438128/viral-aetiologies-of-acute-encephalitis-in-a-hospital-based-south-asian-population
#18
Janarthani Lohitharajah, Neelika Malavige, Carukshi Arambepola, Jithangi Wanigasinghe, Ranjanie Gamage, Padma Gunaratne, Pyara Ratnayake, Thashi Chang
BACKGROUND: The aetiological spectrum of acute encephalitis shows inter- and intra-geographical variations. We aimed to identify the viruses that cause infectious encephalitis in Sri Lanka, which represents a South Asian population. METHODS: A cross-sectional study was conducted among 99 patients with encephalitis/meningoencephalitis admitted to two tertiary-care hospitals in Colombo. Cerebrospinal fluid and serum were tested for conventional and emerging encephalitogenic viruses...
April 24, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28426408/isolation-and-molecular-characterization-of-a-naegleria-strain-from-a-recreational-water-fountain-in-tenerife-canary-islands-spain
#19
María Reyes-Batlle, Carolina Wagner, Atteneri López-Arencibia, Ines Sifaoui, Enrique Martínez-Carretero, Basilio Valladares, Jose E Piñero, Jacob Lorenzo-Morales
Free-Living Amoebae (FLA) are widely distributed protozoa in the environment and have been isolated from many sources such as dust, soil and water. Among the pathogenic genera included in this group Acanthamoeba spp., Naegleria fowleri and Balamuthia mandrillaris have been reported to be causative agents of lethal encephalitis, disseminated infections and keratitis. Naegleria fowleri is a pathogenic FLA species which causes Primary Amoebic Meningoencephalitis (PAM). At present there are not many available data on the distribution of Naegleria species in Spain from environmental sources...
June 1, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28425387/zebra-borne-neurotropic-equid-herpesvirus-1-meningoencephalitis-in-a-thomson-s-gazelle-eudorcas-thomsonii
#20
Kanako Sakaguchi, Kenneth Kim, Ingeborg Langohr, Annabel G Wise, Roger K Maes, Gordon Pirie, Tokuma Yanai, Mohie Haridy, Lorrie Gaschen, Fabio Del Piero
We describe the histopathologic, immunohistochemical, and molecular features of a case of meningoencephalitis in a Thomson's gazelle ( Eudorcas thomsonii) naturally infected with zebra-borne equid herpesvirus 1 (EHV-1) and the implications for the molecular detection of zebra-borne EHV-1. A 4-y-old female Thomson's gazelle was submitted for postmortem examination; no gross abnormalities were noted except for meningeal congestion. Microscopic evaluation demonstrated multifocal nonsuppurative meningoencephalitis with intranuclear eosinophilic and amphophilic inclusion bodies and EHV-9 antigen in neurons...
April 1, 2017: Journal of Veterinary Diagnostic Investigation
keyword
keyword
115250
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"