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https://www.readbyqxmd.com/read/29140879/metastatic-endocervical-adenocarcinoma-in-a-mature-cystic-teratoma-a-case-of-a-tumor-to-tumor-metastasis
#1
Filipa Santos, Catarina Oliveira, João P Caldeira, Ana Coelho, Ana Félix
Tumor-to-tumor metastasis is a rare phenomenon defined as a to metastasis in a histologically distinct tumor. We report an unusual case of a 51-yr-old woman who presented with a cervical, bleeding lesion diagnosed as a poorly differentiated adenocarcinoma, HPV18+. Imaging studies revealed an unresectable cervical carcinoma with an associated left ovarian multicystic teratoma. A suspicious solid nodule within the teratoma was also reported. Bilateral salpingo-oophorectomy was performed before the cervical tumor was treated...
November 14, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29140878/clear-cell-renal-cell-carcinoma-metastatic-to-the-gynecologic-tract-a-clinicopathologic-analysis-of-17-cases
#2
Oluwole Fadare, Mohamed M Desouki, Katja Gwin, Krisztina Z Hanley, Elke A Jarboe, Sharon X Liang, Charles M Quick, Kojo R Rawish, Andres A Roma, Wenxin Zheng, Jonathan L Hecht, Vinita Parkash, Adeboye O Osunkoya
Clear cell renal cell carcinomas (CCRCC) rarely metastasizes to the gynecologic tract. In this study, we analyzed a multi-institutional data set to provide insights into the clinical, morphologic, and immunophenotypic features of this phenomenon. Seveteen metastatic CCRCC involving the gynecologic tract [ovary/fallopian tube (n=9), vulva (n=2), uterine corpus (n=3), cervix (n=2), uterine serosa (n=1)] were analyzed. Mean patient age was 62 yr (range: 45-79 yr). Most cases (15/17) presented as a recurrence 6 to 72 mo postnephrectomy, 1 case was concurrently diagnosed, and 1 case (a cervical metastasis) was diagnosed prenephrectomy...
November 14, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29137078/successful-treatment-of-ovarian-cancer-with-apatinib-combined-with-chemotherapy-a-case-report
#3
Mingzi Zhang, Zhongkai Tian, Yehong Sun
RATIONALE: The standard treatment for ovarian cancer is chemotherapy with 2 drugs (taxanes and platinum drugs). However, the traditional combination of the 2 drugs has many adverse effects (AEs) and the cancer cells will quickly become resistant to the drugs. Apatinib is a small-molecule antiangiogenic agent which has shown promising therapeutic effects against diverse tumor types, but it still remains unknown whether apatinib has an antitumor effect in patients with ovarian cancer. Herein, we present a successfully treated case of ovarian cancer using chemotherapy and apatinib, in order to demonstrate the effectiveness of this new combined regimen in ovarian cancer...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29136731/-the-surgical-treatment-of-ovarian-cancer-metastasis-between-liver-and-diaphragm-a-report-of-83-cases
#4
Y Y Xu, X Lu, Y L Mao, J P Xiong, J Bian, H C Huang, H Y Yang, X T Sang, H T Zhao, H F Xu, T Y Chi, S D Du, S X Zhong, J F Huang
Objective: To explore the safety and feasibility of associating diaphragm resection and liver-diaphragmatic metastasis lesions resection for patients with advanced ovarian cancer. Methods: Retrospectively analysis 83 cases(98 times) of advanced ovarian cancer with liver-diaphragmatic metastasis between January 2012 and December 2016 at Department of Liver Surgery, Peking Union Medical College Hospital.The patients were aged from 19 to 75 years.Surgical procedure included metastatic lesions resection(43 times) and stripping(55 times)...
November 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29133366/lifestyle-and-reproductive-factors-and-ovarian-cancer-risk-by-p53-and-mapk-expression
#5
Holly R Harris, Megan S Rice, Amy L Shafrir, Elizabeth M Poole, Mamta Gupta, Jonathan L Hecht, Kathryn L Terry, Shelley S Tworoger
BACKGROUND: One model of ovarian cancer development model divides tumors into two types. Type I tumors are characterized by KRAS and BRAF mutations, which can activate mitogen-activated protein kinase (MAPK). Type II tumors are characterized by tubal precursor lesions with p53 mutations. We evaluated the association between lifestyle and reproductive factors and risk of ovarian cancer defined by p53 and MAPK expression. METHODS: Epithelial ovarian cancer cases (n=274) and controls (n=1907) were identified from the Nurses' Health Study (NHS) and NHSII prospective cohorts, and the population-based New England Case-Control study...
November 13, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29131012/snail-driving-alternative-splicing-of-cd44-by-esrp1-enhances-invasion-and-migration-in-epithelial-ovarian-cancer
#6
Le Chen, Ying Yao, Lijuan Sun, Jiajia Zhou, Minmin Miao, Shujuan Luo, Guanming Deng, Junjun Li, Jing Wang, Jie Tang
BACKGROUND/AIMS: Our study aims to investigate the role, effect and mechanisms of ESRP1 (epithelial splicing regulatory protein 1) in epithelial-mesenchymal transition (EMT) in epithelial ovarian cancer (EOC). METHODS: Microarray and immunohistochemical analysis of ESRP1 expression were performed in EOC cases. The correlations between ESRP1 expression and clinical factors on EOC were assessed. Lentivirus-mediated RNA interference and EGFP vector which contains ESRP1 gene were used to down-regulate and up-regulate ESRP1 expression in human EOC cell lines...
October 31, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29130934/recurrent-ubiquitin-b-silencing-in-gynecological-cancers-establishes-dependence-on-ubiquitin-c
#7
Alexia T Kedves, Scott Gleim, Xiaoyou Liang, Dennis M Bonal, Frederic Sigoillot, Fred Harbinski, Sneha Sanghavi, Christina Benander, Elizabeth George, Prafulla C Gokhale, Quang-De Nguyen, Paul T Kirschmeier, Robert J Distel, Jeremy Jenkins, Michael S Goldberg, William C Forrester
Transcriptional repression of ubiquitin B (UBB) is a cancer-subtype-specific alteration that occurs in a substantial population of patients with cancers of the female reproductive tract. UBB is 1 of 2 genes encoding for ubiquitin as a polyprotein consisting of multiple copies of ubiquitin monomers. Silencing of UBB reduces cellular UBB levels and results in an exquisite dependence on ubiquitin C (UBC), the second polyubiquitin gene. UBB is repressed in approximately 30% of high-grade serous ovarian cancer (HGSOC) patients and is a recurrent lesion in uterine carcinosarcoma and endometrial carcinoma...
November 13, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29126882/the-role-of-mri-dti-in-predicting-pain-related-to-endometriosis-a-preliminary-study
#8
Maria Grazia Porpora, Valeria Vinci, Corrado De Vito, Giuseppe Migliara, Emanuela Anastasi, Adele Ticino, Serena Resta, Carlo Catalano, Pierluigi Benedetti Panici, Lucia Manganaro
OBJECTIVE: To evaluate the sacral nerve root features by the means of Magnetic Resonance Imaging Diffusion Tensor Imaging (MRI-DTI) tractography in women with endometriosis and /or adenomyosis and to analyze the correlation between DTI abnormalities, pain symptoms, and endometriotic lesions found at surgery. DESIGN: A cross-sectional, observational study (Canadian Task Force classification II-2) SETTING: University hospital PATIENTS: 76 women with clinical suspicion of endometriosis ...
November 7, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29124495/excluding-lynch-syndrome-in-a-female-patient-with-metachronous-dna-mismatch-repair-deficient-colon-and-ovarian-cancer
#9
Stijn Crobach, Anne M L Jansen, Marjolein J L Ligtenberg, Marije Koopmans, Maartje Nielsen, Frederik J Hes, Juul T Wijnen, Winand N M Dinjens, Tom van Wezel, Hans Morreau
Patients synchronously or metachronously presenting with ovarian and colon cancer can pose diagnostic challenges. A primary colon carcinoma can metastasize to one or both ovaries, two independent primary tumors can arise or an ovarian carcinoma can metastasize to the colon. Clinical and immunohistochemical characterization can aid the diagnosis. Recently, we reported that in difficult cases finding pathogenic APC variants supports a colonic origin.In this case report we describe the clinical history of a female patient suspected for Lynch syndrome...
November 9, 2017: Familial Cancer
https://www.readbyqxmd.com/read/29119698/differences-in-the-ultrasound-features-of-papillations-in-unilocular-solid-adnexal-cysts-a-retrospective-international-multicenter-study
#10
Chiara Landolfo, Lil Valentin, Dorella Franchi, Caroline Van Holsbeke, Robert Fruscio, Wouter Froyman, Povilas Sladkevicius, Jeroen Kaijser, Lieveke Ameye, Tom Bourne, Luca Savelli, An Coosemans, Antonia Testa, Dirk Timmerman
OBJECTIVES: The aim is to determine if there are any ultrasound features of papillations or of the cyst wall that can discriminate between benign and malignant unilocular-solid cysts with papillations but no other solid components. METHODS: Patients with an adnexal lesion described at ultrasonography as unilocular-solid with papillations but no other solid components were identified from the International Ovarian Tumor Analysis (IOTA) database derived from seven ultrasound centers...
November 8, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29118475/histological-follow-up-in-patients-with-atypical-glandular-cells-on-pap-smears
#11
Gokhan Boyraz, Derman Basaran, Mehmet Coskun Salman, Akbar Ibrahimov, Sevgen Onder, Orkun Akman, Nejat Ozgul, Kunter Yuce
Context: Atypical glandular cells (AGCs) result in the Papanicolaou (Pap) smear may be associated with significant genital and nongenital neoplastic processes. Aims: To evaluate the underlying histopathology in women who had AGCs on Pap smears. Settings and Design: Retrospective cross-sectional study. Patients and Methods: Clinicopathological data of patients who had AGC on Pap smears and underwent histological workup between January 2004 and December 2014 were retrieved from the computerized database of a tertiary care center...
October 2017: Journal of Cytology
https://www.readbyqxmd.com/read/29113220/pax8-is-a-potential-marker-for-the-diagnosis-of-primary-epithelial-ovarian-cancer
#12
Hong-Juan Chai, Qing Ren, Qin Fan, Liu Ye, Guang-Ye Du, Hua-Wen Du, Wei Xu, Yue Li, Lan Zhang, Zhong-Ping Cheng
The present study aimed to investigate the clinical significance of paired-box 8 (PAX8) in primary epithelial ovarian cancer (PEOC). Using immunohistochemical (IHC) staining, the expression of PAX8 in 60 patients with PEOC, 20 patients with ovarian benign lesions and 10 patients with metastatic ovarian cancer (MOC), was examined based on the clinicopathological profiles of the patients. The correlation between PAX8 expression and the clinicopathological parameters or prognosis of patients was statistically analyzed...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29112653/long-term-results-for-expectant-management-of-ultrasonographically-diagnosed-benign-ovarian-teratomas
#13
M Angela Pascual, Betlem Graupera, Cristina Pedrero, Ignacio Rodriguez, Silvia Ajossa, Stefano Guerriero, Juan Luis Alcázar
OBJECTIVE: To assess the natural history of ultrasonographically diagnosed benign ovarian teratomas in asymptomatic women. METHODS: We conducted a retrospective observational cohort study of 408 women (mean age 36.6 years, range 14-81 years) diagnosed as having an ovarian teratoma by transvaginal ultrasonography (except eight who only had a transabdominal study done) between January 2003 and December 2013 at a single tertiary care institution. Six hundred thirteen women were diagnosed with ovarian teratoma of whom 205 were promptly treated surgically, leaving 408 patients followed conservatively with follow-up scans at 3 and 6 months from diagnosis and then yearly...
November 3, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29102090/comprehensive-genomic-profiling-reveals-inactivating-smarca4-mutations-and-low-tumor-mutational-burden-in-small-cell-carcinoma-of-the-ovary-hypercalcemic-type
#14
Douglas I Lin, Yakov Chudnovsky, Bridget Duggan, Deborah Zajchowski, Joel Greenbowe, Jeffrey S Ross, Laurie M Gay, Siraj M Ali, Julia A Elvin
OBJECTIVE: Small cell carcinoma of the ovary, hypercalcemic-type (SCCOHT) is a rare, extremely aggressive neoplasm that usually occurs in young women and is characterized by deleterious germline or somatic SMARCA4 mutations. We performed comprehensive genomic profiling (CGP) to potentially identify additional clinically and pathophysiologically relevant genomic alterations in SCCOHT. METHODS: CGP assessment of all classes of coding alterations in up to 406 genes commonly altered in cancer and intronic regions for up to 31 genes commonly rearranged in cancer was performed on 18 SCCOHT cases (16 exhibiting classic morphology and 2 cases exhibiting exclusive a large cell variant morphology)...
October 25, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29100623/pathogenesis-of-deep-endometriosis
#15
REVIEW
Stephan Gordts, Philippe Koninckx, Ivo Brosens
The pathophysiology of (deep) endometriosis is still unclear. As originally suggested by Cullen, change the definition "deeper than 5 mm" to "adenomyosis externa." With the discovery of the old European literature on uterine bleeding in 5%-10% of the neonates and histologic evidence that the bleeding represents decidual shedding, it is postulated/hypothesized that endometrial stem/progenitor cells, implanted in the pelvic cavity after birth, may be at the origin of adolescent and even the occasionally premenarcheal pelvic endometriosis...
October 31, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/29093397/a-metastatic-gastric-tumor-from-ovarian-cancer
#16
Mitsuhiro Kono, Yasuaki Nagami, Masaki Ominami, Taishi Sakai, Takeshi Fukuda, Shusei Fukunaga, Fumio Tanaka, Satoshi Sugimori, Hirokazu Yamagami, Tetsuya Tanigawa, Masatsugu Shiba, Kazunari Tominaga, Toshio Watanabe, Yasuhiro Fujiwara, Tetsuo Arakawa
Gastric metastasis from ovarian cancer has rarely been reported. We herein report the case of a 64-year-old woman with gastric metastasis from ovarian cancer that was diagnosed as surgical stage IA. Diagnostic and staging laparotomy showed mucinous carcinoma of the right ovary. At one month after surgery, bone metastasis was detected via scintigraphy. On esophagogastroduodenoscopy, a 10-mm elevated lesion with ulceration on the top was seen in the stomach. The immunohistochemical analysis of biopsy specimens showed that these metastases arose from ovarian cancer...
November 1, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29093245/-expression-of-mir23b-and-sp1-in-ovarian-endometriosisand-their-clinic-significance
#17
Xiaxia Hong, Licong Shen, Wenjun Zhou, Yi Zhang
To investigate the expressions of miR23b and Sp1 in ovarian endometriosis and their clinic significance.
 Methods: qPCR was used to detect the expression of miR23b and Sp1 mRNA in paired ectopic/eutopic and normal endometrium. Immunohistochemistry and Western bolt were used to determine the expression and distribution of Sp1 in paired ectopic/eutopic and normal endometrium. The association of miR23b and Sp1 with the endometriosis was analyzed.
 Results: MiR23b mRNA expression in paired ectopic/eutopic and normal endometrium was gradually increased (P<0...
October 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29090412/improved-debulking-of-peritoneal-tumor-implants-by-near-infrared-fluorescent-nanobody-image-guidance-in-an-experimental-mouse-model
#18
Pieterjan Debie, Marian Vanhoeij, Natalie Poortmans, Janik Puttemans, Kris Gillis, Nick Devoogdt, Tony Lahoutte, Sophie Hernot
PURPOSE: Debulking followed by combination chemotherapy is currently regarded as the most effective treatment for advanced ovarian cancer. Prognosis depends drastically on the degree of debulking. Accordingly, near-infrared (NIR) fluorescence imaging has been proposed to revolutionize cancer surgery by acting as a sensitive, specific, and real-time tool enabling visualization of cancer lesions. We have previously developed a NIR-labeled nanobody that allows fast, specific, and high-contrast imaging of HER2-positive tumors...
October 31, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29079275/endometriosis-especially-mild-disease-a-risk-factor-for-miscarriages
#19
MULTICENTER STUDY
Alexandra Sabrina Kohl Schwartz, Monika Martina Wölfler, Vera Mitter, Martina Rauchfuss, Felix Haeberlin, Markus Eberhard, Stephanie von Orelli, Bruno Imthurn, Patrick Imesch, Daniel Fink, Brigitte Leeners
OBJECTIVE: To investigate the prevalence of miscarriage in women with endometriosis (WwE) compared with disease-free control women (CW). DESIGN: Cross-sectional analysis nested in a retrospective observational study (n = 940). SETTING: Hospitals and associated private practices. PATIENT(S): Previously pregnant women (n = 268) within reproductive age in matched pairs. INTERVENTION(S): Retrospective analysis of surgical reports and self-administered questionnaires...
November 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/29062485/persistent-hyperthyroidism-and-de-novo-graves-ophthalmopathy-after-total-thyroidectomy
#20
Wei Lin Tay, Wann Jia Loh, Lianne Ai Ling Lee, Chiaw Ling Chng
We report a patient with Graves' disease who remained persistently hyperthyroid after a total thyroidectomy and also developed de novo Graves' ophthalmopathy 5 months after surgery. She was subsequently found to have a mature cystic teratoma containing struma ovarii after undergoing a total hysterectomy and salpingo-oophorectomy for an incidental ovarian lesion. LEARNING POINTS: It is important to investigate for other causes of primary hyperthyroidism when thyrotoxicosis persists after total thyroidectomy...
2017: Endocrinology, Diabetes & Metabolism Case Reports
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