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https://www.readbyqxmd.com/read/28718444/tumor-host-cell-interactions-in-ovarian-cancer-pathways-to-therapy-failure
#1
REVIEW
Elke Pogge von Strandmann, Silke Reinartz, Uwe Wager, Rolf Müller
Although most ovarian cancer patients are highly responsive to chemotherapy, they frequently present with recurrent metastatic lesions that result in poor overall survival, a situation that has not changed in the last 20 years. This review discusses new insights into the regulation of ovarian cancer chemoresistance with a focus on the emerging role of immune and other host cells. Here, we summarize the complex molecular pathways that regulate the interaction between tumor and host cells, discuss the limitations of current in vitro and in vivo models for translational studies, and present perspectives for the development of innovative therapies...
February 2017: Trends in Cancer
https://www.readbyqxmd.com/read/28718381/histological-and-immunohistochemical-characterization-of-the-similarity-and-difference-between-ovarian-endometriomas-and-deep-infiltrating-endometriosis
#2
Xishi Liu, Qi Zhang, Sun-Wei Guo
Ovarian endometrioma (OMA) and deep infiltrating endometriosis (DIE) have long been recognized to have different histology and, as such, postulated to be 2 separate disease entities. Few studies, however, have attempted to elucidate the causes for their differences. Making use of ectopic endometrial tissue samples from 25 and 20 women with OMA and DIE, respectively, and control endometrial tissue samples from 25 women without endometriosis, we conducted an immunohistochemical analysis to evaluate the expression of a group of carefully chosen markers for epithelial-mesenchymal transition (EMT), fibroblast-to-myofibroblast transdifferentiation (FMT), smooth muscle metaplasia (SMM), fibrosis, vascularity, hormonal receptors, and proteins involved in epigenetic modifications...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28716306/tertiary-cytoreductive-surgery-in-recurrent-epithelial-ovarian-cancer-a-multicentre-mito-retrospective-study
#3
F Falcone, G Scambia, P Benedetti Panici, M Signorelli, G Cormio, G Giorda, S Bogliolo, M Marinaccio, F Ghezzi, E Rabaiotti, E Breda, G Casella, F Fanfani, V Di Donato, U Leone Roberti Maggiore, S Greggi
OBJECTIVES: To evaluate the impact of tertiary cytoreductive surgery (TCS) on survival in recurrent epithelial ovarian cancer (EOC), and to determine predictors of complete cytoreduction. METHODS: A multi-institutional retrospective study was conducted within the MITO Group on a 5-year observation period. RESULTS: A total of 103 EOC patients with a ≥6month treatment-free interval (TFI) undergoing TCS were included. Complete cytoreduction was achieved in 71 patients (68...
July 14, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28710803/expression-of-the-major-vault-protein-mvp-and-cellular-vault-particles-in-fish
#4
Alyssa L Margiotta, Lisa J Bain, Charles D Rice
Cellular vaults are ubiquitous 13 mega Da multi-subunit ribonuceloprotein particles that may have a role in nucleocytoplasmic transport. Seventy percent of the vault's mass consists of a ≈100 kDa protein, the major vault protein. In humans, a drug resistance -associated protein, originally identified as lung resistance protein in metastatic lung cancer, was ultimately shown to be the previously described major vault protein. In this study, a partial major vault protein sequence was cloned from channel catfish...
July 15, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28707208/opportunistic-salpingectomy-during-vaginal-hysterectomy-for-a-benign-pathological-condition
#5
Gery Lamblin, Capucine Meysonnier, Stéphanie Moret, Béatrice Nadaud, Georges Mellier, Gautier Chene
INTRODUCTION AND HYPOTHESIS: The objective was to evaluate the surgical feasibility of opportunistic salpingectomy or salpingo-oophorectomy during benign vaginal hysterectomy (HV) and the prevalence of occult tubal lesions. METHODS: In this prospective study from 1 September 2013 to 1 November 2015, the prevalence of bilateral salpingectomy with or without ovariectomy and the prevalence of histopathological and immunohistochemical tubal abnormalities were assessed...
July 13, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28706762/metastatic-breast-cancer-with-brca-mutation-discovered-by-next-generation-sequencing-responding-to-olaparib
#6
Wajeeha Rizvi, Phu Truong, Quoc Truong
Breast cancer susceptibility genes 1 and 2 (BRCA1 and BRCA2) mutations are associated with hereditary breast and ovarian cancer syndromes (HBOC). However, certain individuals with breast cancer do not meet high-risk factors for hereditary breast cancer screening based on age, family history, and biology of malignancy. We present a patient with relapsed breast cancer who developed progressive disease with significant tumor burden causing a recurrent pleural effusion. Next-generation sequencing (NGS) done on a tumor biopsy was positive for the BRCA2 mutation...
June 11, 2017: Curēus
https://www.readbyqxmd.com/read/28700429/mucosal-proliferations-in-completely-examined-fallopian-tubes-accompanying-ovarian-low-grade-serous-tumors-neoplastic-precursor-lesions-or-normal-variants-of-benign-mucosa
#7
Rebecca J Wolsky, Matt A Price, Charles J Zaloudek, Joseph T Rabban
Malignant transformation of the fallopian tube mucosa, followed by exfoliation of malignant cells onto ovarian and/or peritoneal surfaces, has been implicated as the origin of most pelvic high-grade serous carcinoma. Whether a parallel pathway exists for pelvic low-grade serous tumors [ovarian serous borderline tumor (SBT) and low-grade serous carcinoma (LGSC)] remains to be fully elucidated. The literature is challenging to interpret due to variation in the diagnostic criteria and terminology for cytologically low-grade proliferations of the fallopian tube mucosa, as well as variation in fallopian tube specimen sampling...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28700421/atypical-proliferative-borderline-serous-tumor-in-the-brain-a-case-report
#8
Deyin Xing, Erik G Jenson, Christopher A Zwick, Fausto J Rodriguez, Robert J Kurman
A 59-year-old woman with a remote history of invasive ductal carcinoma of the breast was found on a follow-up computed tomography scan of her brain to have a 1-cm lesion in the right frontal lobe in 2008. In the ensuing years, before her current admission, multiple imaging studies of the brain revealed that the lesion was stable and it was, therefore, interpreted as a small area of encephalomalacia related to a thrombosed cortical vein, a cavernoma, or treated metastatic breast cancer. In 2013, the patient underwent a bilateral salpingo-oophorectomy for ovarian tumors that were diagnosed as bilateral serous cystadenofibromas...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28698296/prkci-promotes-immune-suppression-in-ovarian-cancer
#9
Sharmistha Sarkar, Christopher A Bristow, Prasenjit Dey, Kunal Rai, Ruth Perets, Alejandra Ramirez-Cardenas, Shruti Malasi, Emmet Huang-Hobbs, Monika Haemmerle, Sherry Y Wu, Michael McGuire, Alexei Protopopov, Shan Jiang, Joyce F Liu, Michelle S Hirsch, Qing Chang, Alexander J Lazar, Anil K Sood, Ronny Drapkin, Ronald DePinho, Giulio Draetta, Lynda Chin
A key feature of high-grade serous ovarian carcinoma (HGSOC) is frequent amplification of the 3q26 locus harboring PRKC-ι (PRKCI). Here, we show that PRKCI is also expressed in early fallopian tube lesions, called serous tubal intraepithelial carcinoma. Transgenic mouse studies establish PRKCI as an ovarian cancer-specific oncogene. Mechanistically, we show that the oncogenic activity of PRKCI relates in part to the up-regulation of TNFα to promote an immune-suppressive tumor microenvironment characterized by an abundance of myeloid-derived suppressor cells and inhibition of cytotoxic T-cell infiltration...
July 11, 2017: Genes & Development
https://www.readbyqxmd.com/read/28694742/clinical-validation-of-a-blood-based-classifier-for-diagnostic-evaluation-of-asymptomatic-individuals-with-pulmonary-nodules
#10
Charles E Birse, Jennifer L Tomic, Harvey I Pass, William N Rom, Robert J Lagier
BACKGROUND: The number of pulmonary nodules detected in the US is expected to increase substantially following recent recommendations for nationwide CT-based lung cancer screening. Given the low specificity of CT screening, non-invasive adjuvant methods are needed to differentiate cancerous lesions from benign nodules to help avoid unnecessary invasive procedures in the asymptomatic population. We have constructed a serum-based multi-biomarker panel and assessed its clinical accuracy in a retrospective analysis of samples collected from participants with suspicious radiographic findings in the Prostate, Lung, Chest and Ovarian (PLCO) cancer screening trial...
2017: Clinical Proteomics
https://www.readbyqxmd.com/read/28692889/dynamic-real-time-in-vivo-confocal-laser-endomicroscopy-of-the-fallopian-tube-during-laparoscopy-in-the-prevention-of-ovarian-cancer
#11
Gautier Chene, Lauriane Chauvy, Annie Buenerd, Stéphanie Moret, Béatrice Nadaud, Philippe Chabert, Gery Lamblin
OBJECTIVES: Recently it has been postulated that most ovarian cancers have a tubal origin. The identification of preinvasive tubal lesions would be of great interest in the early diagnosis of ovarian cancer. Optical biopsy has been developed and validated in the detection of precancerous lesions (such as Barrett's oesophagus). The first objective of this study was to assess the feasibility of optical biopsy in the study of fallopian tubes during laparoscopy. The second objective was to describe the images in benign premalignant and malignant tubes with a histopathological and immunohistochemical (p53 and Ki67 expressions) correlation...
July 5, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28691239/long-term-efficacy-and-safety-of-aromatase-inhibitor-use-for-leiomyomatosis-peritonealis-disseminata
#12
Hitomi Ando, Soshi Kusunoki, Tsuyoshi Ota, Yayoi Sugimori, Shozo Matsuoka, Daiki Ogishima
Leiomyomatosis peritonealis disseminata is a rare disease characterized by pelvic smooth-muscle nodules of various sizes. It is sometimes misdiagnosed as ovarian or peritoneal carcinoma metastasis; therefore, surgical excision for pathological diagnosis is required. Treatment options include bilateral salpingo-oophorectomy (BSO), gonadotrophin-releasing hormone agonist therapy, and aromatase inhibitor therapy. All of these suppress estrogen levels, but a standard treatment has not been established. A 40-year-old woman had multiple pelvic tumors, suspicious for ovarian cancer...
July 10, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28686500/guidelines-for-pathologic-diagnosis-of-malignant-mesothelioma-2017-update-of-the-consensus-statement-from-the-international-mesothelioma-interest-group
#13
Aliya Noor Husain, Thomas V Colby, Nelson G Ordóñez, Timothy Craig Allen, Richard Luther Attanoos, Mary Beth Beasley, Kelly Jo Butnor, Lucian R Chirieac, Andrew M Churg, Sanja Dacic, Françoise Galateau-Sallé, Allen Gibbs, Allen M Gown, Thomas Krausz, Leslie Anne Litzky, Alberto Marchevsky, Andrew G Nicholson, Victor Louis Roggli, Anupama K Sharma, William D Travis, Ann E Walts, Mark R Wick
CONTEXT: - Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose. OBJECTIVE: - To provide updated, practical guidelines for the pathologic diagnosis of MM. DATA SOURCES: - Pathologists involved in the International Mesothelioma Interest Group and others with an interest and expertise in the field contributed to this update. Reference material included up-to-date, peer-reviewed publications and textbooks. CONCLUSIONS: - There was discussion and consensus opinion regarding guidelines for (1) distinguishing benign from malignant mesothelial proliferations (both epithelioid and spindle cell lesions), (2) cytologic diagnosis of MM, (3) recognition of the key histologic features of pleural and peritoneal MM, (4) use of histochemical and immunohistochemical stains in the diagnosis and differential diagnosis of MM, (5) differentiating epithelioid MM from various carcinomas (lung, breast, ovarian, and colonic adenocarcinomas, and squamous cell and renal cell carcinomas), (6) diagnosis of sarcomatoid MM, (7) use of molecular markers in the diagnosis of MM, (8) electron microscopy in the diagnosis of MM, and (9) some caveats and pitfalls in the diagnosis of MM...
July 7, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28684142/neuraxial-anesthesia-in-a-patient-with-anti-n-methyl-d-aspartate-receptor-encephalitis-in-pregnancy-management-for-cesarean-delivery-and-oophorectomy
#14
L Demma, S Norris, J Dolak
We describe the neuraxial anesthetic management of a 28-year-old primigravid patient with severe, treatment-refractory anti-N-methyl-D-aspartate receptor encephalitis undergoing cesarean delivery. The presence of an ovarian teratoma was suspected although not confirmed by imaging. The severity of symptoms, ineffective immunotherapy and the need for chemotherapy necessitated cesarean delivery and resection of a suspected teratoma at 28weeks estimated gestational age. A combined spinal-epidural technique was used...
May 11, 2017: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/28679689/two-different-mutually-exclusively-distributed-tp53-mutations-in-ovarian-and-peritoneal-tumor-tissues-of-a-serous-ovarian-cancer-patient-indicative-for-tumor-origin
#15
Nyamdelger Sukhbaatar, Anna Bachmayr-Heyda, Katharina Auer, Stefanie Aust, Simon Deycmar, Reinhard Horvat, Dietmar Pils
High-grade serous ovarian cancer (HGSOC) is characterized by a TP53 mutation rate of up to 96.7% and associated with a more aggressive tumor biology. The origin of HGSOC is thought to arise either from fallopian tube secretory cells or the ovarian surface epithelium/inclusion cysts, the former with more evidence. Peritoneal tumor spread is heterogeneous, either excessive in the peritoneum (with miliary appearance) or more confined to the ovaries with only few (bigger and exophytically growing) peritoneal implants...
July 2017: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/28678915/increased-expression-of-id2-prelp-and-smoc2-genes-in-patients-with-endometriosis
#16
F M Araujo, J Meola, J C Rosa-E-Silva, C C P Paz, R A Ferriani, A A Nogueira
Endometriosis is a benign, estrogen-dependent disease with symptoms such as pelvic pain and infertility, and it is characterized by the ectopic distribution of endometrial tissue. The expression of the ID2, PRELP and SMOC2 genes was compared between the endometrium of women without endometriosis in the proliferative phase of their menstrual cycle and the eutopic and ectopic endometrium of women with endometriosis in the proliferative phase. Paired tissue samples from 20 women were analyzed: 10 from endometrial and peritoneal endometriotic lesions and 10 from endometrial and ovarian endometriotic lesions...
July 3, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28670494/lycopene-reduces-ovarian-tumor-growth-and-intraperitoneal-metastatic-load
#17
Nina Pauline Holzapfel, Ali Shokoohmand, Ferdinand Wagner, Marietta Landgraf, Simon Champ, Boris Michael Holzapfel, Judith Ann Clements, Dietmar Werner Hutmacher, Daniela Loessner
Mutagens like oxidants cause lesions in the DNA of ovarian and fallopian tube epithelial cells, resulting in neoplastic transformation. Reduced exposure of surface epithelia to oxidative stress may prevent the onset or reduce the growth of ovarian cancer. Lycopene is well-known for its excellent antioxidant properties. In this study, the potential of lycopene in the prevention and treatment of ovarian cancer was investigated using an intraperitoneal animal model. Lycopene prevention significantly reduced the metastatic load of ovarian cancer-bearing mice, whereas treatment of already established ovarian tumors with lycopene significantly diminished the tumor burden...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28668403/f-18-fdg-pet-ct-metabolic-tumor-volume-predicts-overall-survival-in-patients-with-disseminated-epithelial-ovarian-cancer
#18
Rosj Gallicchio, Anna Nardelli, Angela Venetucci, Daniela Capacchione, Alessandra Pelagalli, Cesare Sirignano, Pierpaolo Mainenti, Piernicola Pedicini, Giuseppe Guglielmi, Giovanni Storto
OBJECTIVE: We evaluated the prognostic impact of quantitative assessment by maximum standardized uptake value (SUVmax), metabolic tumour volume (MTV) and tumour lesion glycolysis (TLG) on [F-18] FDG PET/CT for patients with peritoneal carcinomatosis from epithelial ovarian cancer (EOC). METHODS: Thirty-one patients with EOC underwent PET/CT for an early restaging after cytoreductive surgery, having been diagnosed with carcinomatosis (before chemotherapy). The SUVmax, MTV (cm(3); 42% threshold) and TLG (g) were registered on residual peritoneal lesions...
August 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28664938/lef1-is-preferentially-expressed-in-the-tubal-peritoneal-junctions-and-is-a-reliable-marker-of-tubal-intraepithelial-lesions
#19
Elisa Schmoeckel, Ashley A Odai-Afotey, Michael Schleißheimer, Miriam Rottmann, Andrea Flesken-Nikitin, Lora H Ellenson, Thomas Kirchner, Doris Mayr, Alexander Yu Nikitin
Recently it has been reported that serous tubal intraepithelial carcinoma (STIC), the likely precursor of ovarian/extra-uterine high-grade serous carcinoma, are frequently located in the vicinity of tubal-peritoneal junctions, consistent with the cancer-prone features of many epithelial transitional regions. To test if p53 (aka TP53)-signatures and secretory cell outgrowths (SCOUTs) also localize to tubal-peritoneal junctions, we examined these lesions in the fallopian tubes of patients undergoing salpingo-oophorectomy for sporadic high-grade serous carcinomas or as a prophylactic procedure for carriers of familial BRCA1 or 2 mutations...
June 30, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28664915/kinase-driven-metabolic-signalling-as-a-predictor-of-response-to-carboplatin-paclitaxel-adjuvant-treatment-in-advanced-ovarian-cancers
#20
Maria Isabella Sereni, Elisa Baldelli, Guido Gambara, Antonella Ravaggi, K Alex Hodge, David S Alberts, Jose M Guillen-Rodriguez, Ting Dong, Maurizio Memo, Franco Odicino, Roberto Angioli, Lance A Liotta, Sergio L Pecorelli, Emanuel F Petricoin, Mariaelena Pierobon
BACKGROUND: The biological mechanisms underlying early- and advanced-stage epithelial ovarian cancers (EOCs) are still poorly understood. This study explored kinase-driven metabolic signalling in early and advanced EOCs, and its role in tumour progression and response to carboplatin-paclitaxel treatment. METHODS: Tumour epithelia were isolated from two independent sets of primary EOC (n=72 and 30 for the discovery and the validation sets, respectively) via laser capture microdissection...
June 29, 2017: British Journal of Cancer
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