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topic related to colon cancer

Massimiliano Fabozzi, Pia Cirillo, Francesco Corcione
This work is a topic highlight on the surgical treatment of the right colon pathologies, focusing on the literature state of art and comparing the open surgery to the different laparoscopic and robotic procedures. Different laparoscopic procedures have been described for the treatment of right colon tumors: Totally laparoscopic right colectomy, laparoscopic assisted right colectomy, laparoscopic facilitated right colectomy, hand-assisted right colectomy, single incision laparoscopic surgery colectomy, robotic right colectomy...
August 27, 2016: World Journal of Gastrointestinal Surgery
Markus Rentsch, Tobias Schiergens, Andrej Khandoga, Jens Werner
BACKGROUND: Although colorectal surgery is long established as the mainstay treatment for colon cancer, certain topics regarding technical fine-tuning to increase postsurgical recurrence-free survival have remained a matter of debate throughout the past years. These include complete mesocolic excision (CME), treatment strategies for metastatic disease, significance of hyperthermic intraperitoneal chemotherapy (HIPEC), and surgical techniques for the treatment of colorectal cancer recurrence...
June 2016: Visc Med
Rina Miyawaki, Ai Shibata, Kaori Ishii, Koichiro Oka
Newspapers could provide effective and comprehensive information about cancer to the public. The present study conducted a content analysis of cancer-related articles in Japanese newspapers published in 2011. In total, 5,314 articles were identified and subsequently coded. Coding variables included cancer type, the cancer continuum, and topic of articles mentioning cancer. Approximately half mentioned at least one specific type of cancer, with the focus mostly on lung, leukemia, and breast. Stomach and colon cancers, which have the highest morbidity, were relatively underreported...
June 17, 2016: Health Communication
Fernando Galanternik, Gonzalo Recondo, Matías E Valsecchi, Martín Greco, Gonzalo Recondo, Máximo de la Vega, E Diaz Cantón
Colon cancer is a leading cause of cancer related mortality. Until very recently the only existing options that medical oncologists had to treat metastatic colon cancer were a combination of chemotherapy, anti-EGFR and anti-angiogenic agents. We currently have the first proof that immune therapies could be an effective approach to battle colorectal cancers that carry a mismatch repair machinery deficient phenotype. It is expected that as our knowledge of the different mechanisms of immune-resistance grows, this therapeutic modality might soon be applicable to all patients...
2016: Reviews on Recent Clinical Trials
Atsushi Watanabe
Companion diagnostics (CoDx) will likely continue to rapidly increase in number and application to disease areas including solid tumors, for example EGFR for gefitinib and ALK fusion gene for crizotinib in non-small-cell lung cancer; KRAS against the use of cetuximab and panitumumab in colorectal cancer; HER2 for trastuzumab in breast cancer. CoDx are an indispensable part of personalized medicine and pharmacogenomics. In CoDx development, there are still many challenges, such as the business model promoting cooperation between diagnostics and pharmaceutical companies, and also the regulations related to CoDx...
November 2015: Rinsho Byori. the Japanese Journal of Clinical Pathology
Oludotun Adebayo Phillips, Monerah Al-Soraj
No abstract text is available yet for this article.
2016: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Marcelo Buzzi, Franciele de Freitas, Marcos Winter
Diabetic foot ulcers (DFUs) have a significant impact on patient quality of life. A prospective, descriptive pilot study was conducted between May 2012 and December 2013 through the dermatology outpatient unit in a Brazilian hospital to evaluate the clinical benefits of using Calendula officinalis hydroglycolic extract in the treatment of DFUs. Patients diagnosed with a stable neuropathic ulcer of >3 months' duration; ranging in size from 0.5-40 cm(2); without osteomyelitis, gangrene, bone exposure, cancer, or deep tissue infection; ages 18-90 years; with adequate glycemic control and no history of an allergy to C...
March 2016: Ostomy/wound Management
T A Vermeer, R G Orsini, G A P Nieuwenhuijzen, H J T Rutten, F Daams
INTRODUCTION: Mechanical bowel obstruction in rectal cancer is a common problem, requiring stoma placement to decompress the colon and permit neo-adjuvant treatment. The majority of patients operated on in our hospital are referred; after stoma placement at the referring centre without overseeing final type of surgery. Stoma malpositioning and its effects on rectal cancer care are described. METHODS: All patients who underwent surgery for locally advanced or locally recurrent rectal cancer between 2000 and 2013 in our tertiary referral centre were reviewed and included if they received a stoma before curative surgery...
February 2016: European Journal of Surgical Oncology
Yuji Shimamoto, Mamoru Nukatsuka, Teiji Takechi, Masakazu Fukushima
To establish the individualized treatment of patients with colorectal cancer, factors associated with chemotherapeutic effects should be identified. However, to the best of our knowledge, few studies are available on this topic, although it is known that the prognosis of patients and sensitivity to chemotherapy depend on the location of the tumor and that the tumor location is important for individualized treatment. In this study, primary tumors obtained from 1,129 patients with colorectal cancer were used to measure the mRNA expression levels of the following genes associated with the effects of standard chemotherapy for colorectal cancer: 5-fluorouracil (5-FU)-related thymidylate synthase (TYMS), dihydropyrimidine dehydrogenase (DPYD) and thymidine phosphorylase (TYMP); folate-related dihydrofolate reductase (DHFR), folylpolyglutamate synthase (FPGS) and gamma-glutamyl hydrolase (GGH); irinotecan-related topoisomerase I (TOP1); oxaliplatin-related excision repair cross-complementing 1 (ERCC1); biologic agent-related vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR)...
February 2016: International Journal of Molecular Medicine
K Seitz
The successful collaboration among Ultraschall in der Medizin/ European Journal of Ultrasound (UiM/EJU), DEGUM, ÖGUM and SGUM as well as Thieme Verlag was confirmed in the respective general meetings in Davos recently, and it was agreed that such cooperation should continue in coming years. Last year, in discussions with the previous DEGUM board of directors the issue of orientation of the content of UiM/EJU, among other things, was an essential topic. Briefly stated, the constructive criticism was: too much science, too little continuing education...
December 2015: Ultraschall in der Medizin
Denis Maillet, Hui K Gan, Jean-Yves Blay, Benoit You, Julien Péron
BACKGROUND: Randomised controlled trials (RCTs) represent a major source of information on treatment-related adverse events (AEs). In this study, we reviewed the use and the reporting methods of aggregated-AEs (A-AEs) outcomes in RCTs reports published in oncology and compared that to the expectations of European Organisation for Research and Treatment of Cancer (EORTC) membership. METHODS: RCTs reports published between 2007 and 2011 were reviewed regarding the reporting of A-AEs-outcomes...
January 2016: European Journal of Cancer
Jianguo Shi, Lijuan Xiong, Jiaoyuan Li, Heng Cao, Wen Jiang, Bo Liu, Xueqin Chen, Cheng Liu, Ke Liu, Guobin Wang, Kailin Cai
For many years, the question of whether hyperglycaemia, a manifestation of prediabetes, diabetes mellitus and metabolic syndrome, is a risk factor for colorectal cancer has been intensely studied. In fact, even after the conclusion of several prospective studies, the topic is still controversial. We conducted a systematic review and meta-analysis to investigate the dose-response relationship between blood glucose concentration and the incidence of colorectal cancer. A linear (P = 0.303 for non-linearity) dose-response relationship was observed between fasting plasma glucose (FPG) and colorectal cancer risk without significant heterogeneity...
2015: Scientific Reports
Xing Chen
Accumulating experimental studies have demonstrated important associations between alterations and dysregulations of lncRNAs and the development and progression of various complex human diseases. Developing effective computational models to integrate vast amount of heterogeneous biological data for the identification of potential disease-lncRNA associations has become a hot topic in the fields of human complex diseases and lncRNAs, which could benefit lncRNA biomarker detection for disease diagnosis, treatment, and prevention...
2015: Scientific Reports
Simona Eliza Giuşcă, Irina Draga Căruntu, Anca Maria Cîmpean, Roxana Elena Avadanei, Amalia Raluca Balica, Andreea Adriana Jitariu, Marius Raica
The prognostic value of mast cells (MCs) in patients with liver metastases is a relatively new topic. The present study comparatively assessed tryptase-positive (MCT(+)) and CD117(+) MCs in liver metastases from various sites and correlated their expression with clinicopathological prognostic factors and survival. Our data pointed to differences in MCT and CD117 expression in liver metastases that seem to be related to the origin of the primary tumor. For colon cancer metastases, intra-tumor MCT(+) MCs were significantly correlated with tumor grade and nodal status, while peritumoral MCT(+) MCs and peritumoral CD117(+) MCs were significantly correlated with overall survival...
October 2015: Anticancer Research
Aleksandra Kawczyk-Krupka, Andrzej M Bugaj, Wojciech Latos, Katarzyna Zaremba, Katarzyna Wawrzyniec, Marek Kucharzewski, Aleksander Sieroń
BACKGROUND: Photodynamic therapy (PDT) is used in many different oncologic fields. Also in gastroenterology, where have been a few attempts to treat both the premalignant lesion and advanced colorectal cancer (CRC). This review aims to give a general overview of preclinical photodynamic studies related to CRC cells and animal studies of photodynamic effects related to CRC treatment to emphasize their potential in study of PDT mechanism, safety and efficiency to translate these results into clinical benefit in CRC treatment...
March 2016: Photodiagnosis and Photodynamic Therapy
Marine Jary, Christophe Borg, Olivier Bouché, Stéfano Kim, Thierry André, Jaafar Bennouna
Ten years after the approval of bevacizumab in colorectal cancer patients, results from ML18147 and CORRECT studies have recently demonstrated the possibility to target angiogenesis in patients previously exposed to anti-VEGF. An increasing number of anti-angiogenic treatments are now available, however, no biomarker has yet succeeded in rationalizing our therapeutic strategies. Nevertheless, several lessons have been learned from preclinical and pivotal clinical studies. The first clinical trials demonstrated a survival benefit, adding VEGFA targeting monoclonal antibodies to chemotherapy in metastatic colorectal cancer patients (AVF2107, ECOG 3200)...
September 2015: Bulletin du Cancer
U Seeland, U Heger, K Heise, K Ott
Systematic analyses of gender effects in gastrointestinal malignancies are currently lacking, partly because sex and gender have not been used as stratification criteria in major studies on the topic. It is, however, indisputable that gastrointestinal tumours differ in risk factors, incidence and prognosis between the genders. This review summarises the most important findings on differences related to biological sex and sociocultural gender and discusses anatomic specifics with immediate significance for surgical interventions...
June 2015: Zentralblatt Für Chirurgie
Matthew M Harkenrider, Fiori Alite, Scott R Silva, William Small
Cervical cancer is a disease that requires considerable multidisciplinary coordination of care and labor in order to maximize tumor control and survival while minimizing treatment-related toxicity. As with external beam radiation therapy, the use of advanced imaging and 3-dimensional treatment planning has generated a paradigm shift in the delivery of brachytherapy for the treatment of cervical cancer. The use of image-based brachytherapy, most commonly with magnetic resonance imaging (MRI), requires additional attention and effort by the treating physician to prescribe dose to the proper volume and account for adjacent organs at risk...
July 15, 2015: International Journal of Radiation Oncology, Biology, Physics
Benjamin Jorgensen, Jason Knudtson
Colorectal cancer (CRC) remains one of the most commonly diagnosed cancers in the U.S. Its incidence and mortality have shown a decreasing trend over the last several decades. The greatest contribution to this trend has been colorectal cancer screening. Colonoscopy continues to be the preferred screening modality. However, recommendations for the use of screening tests other than colonoscopy have generated much interest. Guidelines regarding current screening and surveillance recommendations have recently been updated by expert panels, such as the U...
2015: South Dakota Medicine: the Journal of the South Dakota State Medical Association
Hong-Jun Yoon, Georgia Tourassi
Analyzing the contents of online social networks is an effective process for monitoring and understanding peoples' behaviors. Since the nature of conversation and information propagation is similar to traditional conversation and learning, one of the popular socio-cognitive methods, social cognitive theory was applied to online social networks to. Two major news topics about colon cancer were chosen to monitor traffic of Twitter messages. The activity of "leaders" on the issue (i.e., news companies or people will prior Twitter activity on topics related to colon cancer) was monitored...
May 2014: Annual ORNL Biomedical Science and Engineering Center Conference
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