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https://www.readbyqxmd.com/read/28097472/proceedings-of-the-third-international-molecular-pathological-epidemiology-mpe-meeting
#1
REVIEW
Peter T Campbell, Timothy R Rebbeck, Reiko Nishihara, Andrew H Beck, Colin B Begg, Alexei A Bogdanov, Yin Cao, Helen G Coleman, Gordon J Freeman, Yujing J Heng, Curtis Huttenhower, Rafael A Irizarry, N Sertac Kip, Franziska Michor, Daniel Nevo, Ulrike Peters, Amanda I Phipps, Elizabeth M Poole, Zhi Rong Qian, John Quackenbush, Harlan Robins, Peter K Rogan, Martha L Slattery, Stephanie A Smith-Warner, Mingyang Song, Tyler J VanderWeele, Daniel Xia, Emily C Zabor, Xuehong Zhang, Molin Wang, Shuji Ogino
Molecular pathological epidemiology (MPE) is a transdisciplinary and relatively new scientific discipline that integrates theory, methods, and resources from epidemiology, pathology, biostatistics, bioinformatics, and computational biology. The underlying objective of MPE research is to better understand the etiology and progression of complex and heterogeneous human diseases with the goal of informing prevention and treatment efforts in population health and clinical medicine. Although MPE research has been commonly applied to investigating breast, lung, and colorectal cancers, its methodology can be used to study most diseases...
January 17, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28048893/mo-de-209-01-primer-on-tomosynthesis
#2
A Maidment
: Digital Breast Tomosynthesis (DBT) is rapidly replacing mammography as the standard of care in breast cancer screening and diagnosis. DBT is a form of computed tomography, in which a limited set of projection images are acquired over a small angular range and reconstructed into tomographic data. The angular range varies from 15° to 50° and the number of projections varies between 9 and 25 projections, as determined by the equipment manufacturer. It is equally valid to treat DBT as the digital analog of classical tomography - that is, linear tomography...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048241/mo-de-209-02-tomosynthesis-reconstruction-methods
#3
J Mainprize
: Digital Breast Tomosynthesis (DBT) is rapidly replacing mammography as the standard of care in breast cancer screening and diagnosis. DBT is a form of computed tomography, in which a limited set of projection images are acquired over a small angular range and reconstructed into tomographic data. The angular range varies from 15° to 50° and the number of projections varies between 9 and 25 projections, as determined by the equipment manufacturer. It is equally valid to treat DBT as the digital analog of classical tomography - that is, linear tomography...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048058/mo-de-209-04-radiation-dosimetry-in-breast-tomosynthesis
#4
I Sechopoulos
: Digital Breast Tomosynthesis (DBT) is rapidly replacing mammography as the standard of care in breast cancer screening and diagnosis. DBT is a form of computed tomography, in which a limited set of projection images are acquired over a small angular range and reconstructed into tomographic data. The angular range varies from 15° to 50° and the number of projections varies between 9 and 25 projections, as determined by the equipment manufacturer. It is equally valid to treat DBT as the digital analog of classical tomography - that is, linear tomography...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047595/mo-de-209-03-assessing-image-quality
#5
W Zhao
: Digital Breast Tomosynthesis (DBT) is rapidly replacing mammography as the standard of care in breast cancer screening and diagnosis. DBT is a form of computed tomography, in which a limited set of projection images are acquired over a small angular range and reconstructed into tomographic data. The angular range varies from 15° to 50° and the number of projections varies between 9 and 25 projections, as determined by the equipment manufacturer. It is equally valid to treat DBT as the digital analog of classical tomography - that is, linear tomography...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046829/mo-de-209-00-dbt-physics-basic-to-advanced
#6
Andrew D Maidment
: Digital Breast Tomosynthesis (DBT) is rapidly replacing mammography as the standard of care in breast cancer screening and diagnosis. DBT is a form of computed tomography, in which a limited set of projection images are acquired over a small angular range and reconstructed into tomographic data. The angular range varies from 15° to 50° and the number of projections varies between 9 and 25 projections, as determined by the equipment manufacturer. It is equally valid to treat DBT as the digital analog of classical tomography - that is, linear tomography...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27861384/trends-of-triple-negative-breast-cancer-research-2007-2015-a-bibliometric-study
#7
Yiran Wang, Xiao Zhai, Chuan Liu, Ning Wang, Yajie Wang
BACKGROUND: Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype. However, there have been limited data to evaluate the trend of TNBC research. This study aims to investigate the trend of TNBC research and compare the contribution of research from different regions, organizations, and authors. METHODS: TNBC-related publications from 2007 to 2015 were retrieved from the Web of Science database. Excel 2013 (Redmond, Washington, USA), GraphPad Prism 5 (GraphPad Prism Software Inc...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27809814/a-consultation-training-program-for-physicians-for-communication-about-complementary-medicine-with-breast-cancer-patients-a-prospective-multi-center-cluster-randomized-mixed-method-pilot-study
#8
Susanne Blödt, Nadine Mittring, Lena Schützler, Felix Fischer, Christine Holmberg, Markus Horneber, Adele Stapf, Claudia M Witt
BACKGROUND: The aim was to develop and evaluate a training program for physicians for communicating with breast cancer patients about complementary medicine (CM). METHODS: In a cluster-randomized pilot trial eight breast cancer centers (two physicians per center) were randomized to either a complementary communication training program (9 h e-learning + 20 h on-site skills training) or to a control group without training. Each physician was asked to consult ten patients for whom he or she is not the physician in charge...
November 4, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27803477/pharmaceutical-investigation-for-individualized-and-optimal-cancer-pharmacotherapy
#9
Tomohiro Terada
 After the year 2000, the treatment of cancer remarkably changed, including the development of outpatient cancer chemotherapy. Meanwhile, we have encountered many clinical problems related to cancer patient pharmacy services. To resolve these problems, I have tried to establish the individualized and optimal cancer pharmacotherapy utilizing the findings of basic research. In this review, three topics of my research will be introduced. 1) In 2005, information regarding the genetic polymorphism of UGT1A1*28 was described in the package insert of the drug irinotecan in the United States...
2016: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/27776496/health-promoting-practices-and-personal-lifestyle-behaviors-of-brazilian-health-professionals
#10
Karen D Hidalgo, Grégore I Mielke, Diana C Parra, Felipe Lobelo, Eduardo J Simões, Grace O Gomes, Alex A Florindo, Mário Bracco, Lenildo Moura, Ross C Brownson, Michael Pratt, Luiz R Ramos, Pedro C Hallal
BACKGROUND: This study was conducted to examine the lifestyle behaviors and health promoting practices of physicians, nurses, and community health workers in Brazil. METHODS: A random sample of primary health care units in Brazil was selected, and a pretested questionnaire was administered via phone interviews, in 2011, to 182 physicians, 347 nurses, and 269 community health workers, totaling 798 health professionals. The total initial sample included 1600 eligible health professionals...
October 24, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27749791/possible-efficacy-of-topical-dorzolamide-in-the-treatment-of-paclitaxel-related-cystoid-macular-edema
#11
Rahul Dwivedi, Sambath Tiroumal
PURPOSE: Paclitaxel (Taxol) is a microtubule-stabilizing agent and belongs to the taxane group of chemotherapeutic drugs. It is used to treat numerous malignancies, such as breast and lung cancers. A rare side effect of this drug includes cystoid macular edema (CME), which is presumed to resolve after cessation of Paclitaxel. We present a case of topical Dorzolamide 2% (Trusopt) having a possible successful effect in the treatment of Paclitaxel-related nonresolving CME. By highlighting this rare ocular side effect of a common chemotherapeutic agent, which fails to resolve upon cessation of the drug alone, we suggest a possible treatment that may help other ophthalmologists in their management of similar cases...
October 4, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27747469/nonsupport-versus-varying-levels-of-person-centered-emotional-support-a-study-of-women-with-breast-cancer
#12
Colter D Ray, Alaina M Veluscek
Social support studies often focus on psychological outcomes for the support recipient and also presume potential support providers who will attempt to provide support in the first place. Therefore, the negative relational outcomes associated with not receiving emotional support when support is expected (nonsupport) are an understudied topic. Instances of nonsupport were compared to various emotional support messages on relational and psychological outcomes to understand how nonsupport compares against support messages of varying quality...
October 17, 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/27732128/establishing-consensus-on-residency-education-in-women-s-health
#13
Amy H Farkas, Sarah Tilstra, Sonya Borrero, Melissa McNeil
BACKGROUND: Internal medicine residents are expected to be able to provide gender-specific care. The objective of this study was to develop a consensus list of core topics and procedural skills in women's health to allow residency program directors to prioritize and standardize educational efforts in women's health. METHODS: We conducted a two-round Delphi of women's health experts. Participants were given a list of topics and asked to: (1) rank each topic based on how important they felt each topic was for internal medicine residents to be proficient in upon graduation, and (2) identify which topics were critical for a women's health curriculum...
January 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/27685991/multiplexed-molecular-imaging-of-biomarker-targeted-sers-nanoparticles-on-fresh-tissue-specimens-with-channel-compressed-spectrometry
#14
Soyoung Kang, Yu Wang, Nicholas P Reder, Jonathan T C Liu
Biomarker-targeted surface-enhanced Raman scattering (SERS) nanoparticles (NPs) have been explored as a viable option for targeting and imaging multiple cell-surface protein biomarkers of cancer. While it has been demonstrated that this Raman-encoded molecular imaging (REMI) technology may potentially be used to guide tumor-resection procedures, the REMI strategy would benefit from further improvements in imaging speed. Previous implementations of REMI have utilized 1024 spectral channels (camera pixels) in a commercial spectroscopic CCD to detect the spectral signals from multiplexed SERS NPs, a strategy that enables accurate demultiplexing of the relative concentration of each NP "flavor" within a mixture...
2016: PloS One
https://www.readbyqxmd.com/read/27627986/interest-in-integrative-medicine-among-postmenopausal-hormone-receptor-positive-breast-cancer-patients-in-the-evaluate-tm-study
#15
Carolin C Hack, Peter A Fasching, Tanja Fehm, Johann de Waal, Mahdi Rezai, Bernd Baier, Gerold Baake, Hans-Christian Kolberg, Martin Guggenberger, Mathias Warm, Nadia Harbeck, Rachel Wuerstlein, Jörg-Uwe Deuker, Peter Dall, Barbara Richter, Grischa Wachsmann, Cosima Brucker, Jan W Siebers, Nikos Fersis, Thomas Kuhn, Christopher Wolf, Hans-Walter Vollert, Georg-Peter Breitbach, Wolfgang Janni, Robert Landthaler, Andreas Kohls, Daniela Rezek, Thomas Noesslet, Gunnar Fischer, Stefan Henschen, Thomas Praetz, Volker Heyl, Thorsten Kühn, Thomas Krauss, Christoph Thomssen, Andre Hohn, Hans Tesch, Christoph Mundhenke, Alexander Hein, Claudia Rauh, Christian M Bayer, Adib Jacob, Katja Schmidt, Erik Belleville, Peyman Hadji, Sara Y Brucker, Diethelm Wallwiener, Sherko Kümmel, Matthias W Beckmann, Daniela Paepke
Background Breast cancer patients often use complementary and alternative medicine, but few prospectively collected data on the topic are available specifically for postmenopausal breast cancer patients. A large prospective study was therefore conducted within a noninterventional study in order to identify the characteristics of patients interested in integrative medicine. Methods The EvAluate-TM study is a prospective, multicenter noninterventional study in which treatment with the aromatase inhibitor letrozole was evaluated in postmenopausal women with hormone receptor-positive primary breast cancer...
September 14, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27572551/cost-utility-analyses-of-drug-therapies-in-breast-cancer-a-systematic-review
#16
REVIEW
Virginie Nerich, Sopany Saing, Eva Maria Gamper, Georg Kemmler, Franck Daval, Xavier Pivot, Bernhard Holzner
The economic evaluation (EE) of health care products has become a necessity. Their quality must be high in order to trust the results and make informed decisions. While cost-utility analyses (CUAs) should be preferred to cost-effectiveness analyses in the oncology area, the quality of breast cancer (BC)-related CUA has been given little attention so far. Thus, firstly, a systematic review of published CUA related to drug therapies for BC, gene expression profiling, and HER2 status testing was performed. Secondly, the quality of selected CUA was assessed and the factors associated with a high-quality CUA identified...
October 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27557845/towards-real-time-topical-detection-and-characterization-of-fdg-dose-infiltration-prior-to-pet-imaging
#17
Jason M Williams, Lori R Arlinghaus, Sudheer D Rani, Martha D Shone, Vandana G Abramson, Praveen Pendyala, A Bapsi Chakravarthy, William J Gorge, Joshua G Knowland, Ronald K Lattanze, Steven R Perrin, Charles W Scarantino, David W Townsend, Richard G Abramson, Thomas E Yankeelov
PURPOSE: To dynamically detect and characterize (18)F-fluorodeoxyglucose (FDG) dose infiltrations and evaluate their effects on positron emission tomography (PET) standardized uptake values (SUV) at the injection site and in control tissue. METHODS: Investigational gamma scintillation sensors were topically applied to patients with locally advanced breast cancer scheduled to undergo limited whole-body FDG-PET as part of an ongoing clinical study. Relative to the affected breast, sensors were placed on the contralateral injection arm and ipsilateral control arm during the resting uptake phase prior to each patient's PET scan...
December 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27550949/an-evidence-based-review-of-the-efficacy-of-perioperative-analgesic-techniques-for-breast-cancer-related-surgery
#18
Gloria S Cheng, Brian M Ilfeld
OBJECTIVE: To review the published evidence regarding perioperative analgesic techniques for breast cancer-related surgery. DESIGN: Topical review. METHODS: Randomized, controlled trials (RCTs) were selected for inclusion in the review. Also included were large prospective series providing estimates of potential risks and technical reports and small case series demonstrating a new technique or approaches of interest to clinicians. RESULTS: A total of 514 abstracts were reviewed, with 284 studies meeting criteria for full review...
August 22, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/27513509/-not-available
#19
Wu Zhihui, Yan Weihua, Wu Zupei, Huang Jinlin
OBJECTIVES: The association between fish consumption and the risk of breast cancer has not been established yet. Results from epidemiological studies are inconsistent. We conducted a meta-analysis to examine the association between fish consumption and the risk of breast cancer. METHODS: We identified eligible studies in Medline and EMBASE up to February 2015 and the reference lists of original studies and review articles on this topic. Summary relative risks with their 95% confidence intervals were calculated with a random-effects model...
June 30, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27461599/exploring-the-role-of-dietary-factors-in-the-development-of-breast-cancer
#20
REVIEW
Saurabh RamBihariLal Shrivastava, Prateek Saurabh Shrivastava, Jegadeesh Ramasamy
The aim of the current review is to assess the magnitude of the breast cancer, and to explore the contribution of different dietary constituents in both the causation and the prevention of the disease. An exhaustive search for all materials related to the topic was made in different search engines, including PubMed, World Health Organization Web site, and Google scholar, for a duration of 30 days (June 2014). Relevant documents, systematic reviews, technical publication series, research articles, books, and guidelines focusing on the association of dietary factors and breast cancer, published in 1998-2014 were included in the review...
April 2016: Journal of Cancer Research and Therapeutics
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