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topic related to pancreas cancer

Kasper A Overbeek, Djuna L Cahen, Marcia Irene Canto, Marco J Bruno
Despite its low incidence in the general population, pancreatic cancer is one of the leading causes of cancer-related mortality. Survival greatly depends on operability, but most patients present with unresectable disease. Therefore, there is great interest in the early detection of pancreatic cancer and its precursor lesions by surveillance. Worldwide, several programs have been initiated for individuals at high risk for pancreatic cancer. Their first results suggest that surveillance in high-risk individuals is feasible, but their effectiveness in decreasing mortality remains to be proven...
December 2016: Best Practice & Research. Clinical Gastroenterology
Deniece Riviere, Kurinchi Selvan Gurusamy, David A Kooby, Charles M Vollmer, Marc G H Besselink, Brian R Davidson, Cornelis J H M van Laarhoven
BACKGROUND: Surgical resection is currently the only treatment with the potential for long-term survival and cure of pancreatic cancer. Surgical resection is provided as distal pancreatectomy for cancers of the body and tail of the pancreas. It can be performed by laparoscopic or open surgery. In operations on other organs, laparoscopic surgery has been shown to reduce complications and length of hospital stay as compared with open surgery. However, concerns remain about the safety of laparoscopic distal pancreatectomy compared with open distal pancreatectomy in terms of postoperative complications and oncological clearance...
April 4, 2016: Cochrane Database of Systematic Reviews
Kurinchi Selvan Gurusamy, Charnelle Lusuku, Constantine Halkias, Brian R Davidson
BACKGROUND: Surgical excision by removal of the head of the pancreas to decompress the obstructed ducts is one of the treatment options for people with symptomatic chronic pancreatitis. Surgical excision of the head of the pancreas can be performed by excision of the duodenum along with the head of the pancreas (pancreaticoduodenectomy (PD)) or without excision of the duodenum (duodenum-preserving pancreatic head resection (DPPHR)). There is currently no consensus on the method of pancreatic head resection in people with chronic pancreatitis...
February 3, 2016: Cochrane Database of Systematic Reviews
K Seitz
The successful collaboration among Ultraschall in der Medizin/ European Journal of Ultrasound (UiM/EJU), DEGUM, ÖGUM and SGUM as well as Thieme Verlag was confirmed in the respective general meetings in Davos recently, and it was agreed that such cooperation should continue in coming years. Last year, in discussions with the previous DEGUM board of directors the issue of orientation of the content of UiM/EJU, among other things, was an essential topic. Briefly stated, the constructive criticism was: too much science, too little continuing education...
December 2015: Ultraschall in der Medizin
NaNa Keum, Darren C Greenwood, Dong Hoon Lee, Rockli Kim, Dagfinn Aune, Woong Ju, Frank B Hu, Edward L Giovannucci
BACKGROUND: Adiposity, measured by body mass index, is implicated in carcinogenesis. While adult weight gain has diverse advantages over body mass index in measuring adiposity, systematic reviews on adult weight gain in relation to adiposity-related cancers are lacking. METHODS: PubMed and Embase were searched through September 2014 for prospective observational studies investigating the relationship between adult weight gain and the risk of 10 adiposity-related cancers...
February 2015: Journal of the National Cancer Institute
NaNa Keum, Darren C Greenwood, Dong Hoon Lee, Rockli Kim, Dagfinn Aune, Woong Ju, Frank B Hu, Edward L Giovannucci
BACKGROUND: Adiposity, measured by body mass index, is implicated in carcinogenesis. While adult weight gain has diverse advantages over body mass index in measuring adiposity, systematic reviews on adult weight gain in relation to adiposity-related cancers are lacking. METHODS: PubMed and Embase were searched through September 2014 for prospective observational studies investigating the relationship between adult weight gain and the risk of 10 adiposity-related cancers...
March 2015: Journal of the National Cancer Institute
Franscois Runau, Ali Arshad, John Isherwood, Leonie Norris, Lynne Howells, Matthew Metcalfe, Ashley Dennison
Pancreatic cancer is a disease with a significantly poor prognosis. Despite modern advances in other medical, surgical, and oncologic therapy, the outcome from pancreatic cancer has improved little over the last 40 years. To improve the management of this difficult disease, trials investigating the use of dietary and parenteral fish oils rich in omega-3 (ω-3) fatty acids, exhibiting proven anti-inflammatory and anticarcinogenic properties, have revealed favorable results in pancreatic cancers. Proteomics is the large-scale study of proteins that attempts to characterize the complete set of proteins encoded by the genome of an organism and that, with the use of sensitive mass spectrometric-based techniques, has allowed high-throughput analysis of the proteome to aid identification of putative biomarkers pertinent to given disease states...
June 2015: Nutrition in Clinical Practice
L Jiang, K H Yang, Y Chen, Q L Guan, P Zhao, J H Tian, Q Wang
BACKGROUND: The extent of lymphadenectomy in the treatment of gastric cancer has been debated for more than two decades. This meta-analysis sought to evaluate the effectiveness and safety of extended lymphadenectomy in patients with gastric cancer. METHODS: A comprehensive search was performed to identify randomized clinical trials (RCTs) comparing the outcomes of D1 and D2 dissection for gastric cancer in PubMed, EMBASE, the Cochrane Library, Science Citation Index, Web of Science and the Chinese Biomedical Literature Database in any language from inception of the database to March 2012...
May 2014: British Journal of Surgery
Kurinchi Selvan Gurusamy, Senthil Kumar, Brian R Davidson, Giuseppe Fusai
BACKGROUND: Pancreatic cancer is an aggressive cancer. Resection of the cancer is the only treatment with the potential to achieve long-term survival. However, a third of patients with pancreatic cancer have locally advanced cancer involving adjacent structures such as blood vessels which are not usually removed because of fear of increased complications after surgery. Such patients often receive palliative treatment. Resection of the pancreas along with the involved vessels is an alternative to palliative treatment for patients with locally advanced pancreatic cancer...
2014: Cochrane Database of Systematic Reviews
Raquel Ferreira de Menezes, Anke Bergmann, Luiz Claudio Santos Thuler
This study aimed to discuss the consumption of alcohol as a risk factor for major cancers. We performed a search in the PubMed database, using the following inclusion criteria: meta-analysis published in English in the last 10 years that addressed the relationship between alcohol and the risk of developing cancer. The results indicate that moderate to heavy consumption of alcohol increases the risk of developing cancer of the oral cavity and pharynx, esophagus, stomach, larynx, colorectum, central nervous system, pancreas, breast and prostate...
2013: Asian Pacific Journal of Cancer Prevention: APJCP
Lamberto Manzoli, Carlo La Vecchia, Maria Elena Flacco, Lorenzo Capasso, Valentina Simonetti, Stefania Boccia, Angela Di Baldassarre, Paolo Villari, Andrea Mezzetti, Giancarlo Cicolini
BACKGROUND: While electronic cigarettes are forbidden in several countries, their sales are exploding in many others. Although e-cigarettes have been proposed as long-term substitutes for traditional smoking or as a tool for smoking cessation, very scarce data are available on their efficacy and safety.We describe the protocol of a 5-year multicentric prospective study aimed to evaluate short- and long-term adherence to e-cigarette smoking and the efficacy of e-cigarettes in reducing and/or quitting traditional cigarette smoking...
September 24, 2013: BMC Public Health
Tao Liu, Qin-er Xu, Chuan-hui Zhang, Peng Zhang
METHODS: We searched MEDLINE and EMBASE for epidemiologic studies on occupational exposure to methylene chloride and risk of cancer. Estimates of study-specific odds ratios (ORs) were calculated using inverse-variance-weighted fixed-effects models and random-effects models. Statistical tests for heterogeneity were applied. RESULTS: We summarized data from five cohort studies and 13 case-control studies. The pooled OR for multiple myeloma was (OR 2.04; 95 % CI 1...
December 2013: Cancer Causes & Control: CCC
Monica Franciosi, Giuseppe Lucisano, Emanuela Lapice, Giovanni F M Strippoli, Fabio Pellegrini, Antonio Nicolucci
AIMS/HYPOTHESIS: Diabetes treatments were related with either an increased or reduced risk of cancer. There is ongoing debate about a potential protective action of metformin. To summarize evidence on the association between metformin and risk of cancer and cancer mortality in patients with diabetes. METHODS: HASH(0x40d16f0) DATA SOURCE: MEDLINE and EMBASE (January 1966-April 2012). We selected randomized studies comparing metformin and other hypoglycaemic agents and observational studies exploring the association between exposure to metformin and cancer...
2013: PloS One
Krzysztof Labuzek, Michał Kozłowski, Dawid Szkudłapski, Patrycja Sikorska, Monika Kozłowska, Bogusław Okopień
A lot of contradictory data regarding the serious side effects of incretin-based therapies are currently available, with more being prepared or published every month. Considering the widespread use of these drugs it should be considered a priority to establish both short- and long-term risks connected with incretin treatment. We performed an extensive literature search of the PubMed database looking for articles dealing with connections between incretin-based therapies and pancreatitis, pancreatic cancer, thyroid cancer and other neoplasms...
April 2013: European Journal of Internal Medicine
Eugenia Allegra, Serena Trapasso
Cancer stem cells (CSCs), also called "cells that start the tumor," represent in themselves one of the most topical and controversial issues in the field of cancer research. Tumor stem cells are able to self-propagate in vitro (self-renewal), giving rise both to other tumor stem cells and most advanced cells in the line of differentiation (asymmetric division). A final characteristic is tumorigenicity, a fundamental property, which outlines the tumor stem cell as the only cell able to initiate the formation of a tumor when implanted in immune-deficient mice...
2012: OncoTargets and Therapy
P Pérez Segura, C Guillén Ponce, T Ramón Y Cajal, R Serrano Blanch, E Aranda
Pancreatic carcinoma (PC) represents the fourth leading cause of cancer death in Spain with a death rate of 2,400 males and 2,000 females per year. Poor outcome related to its silent nature and the lack of reliable secondary prevention measures translate into advanced-stage diagnosis, 75 % of deaths within the first year of diagnosis and 5-year survival rate of <5 %. Family history was first recognized as a risk factor for PC. Further population-based and case-control studies subsequently found that 7...
August 2012: Clinical & Translational Oncology
Carla J Berg, Akilah N Thomas, Ann C Mertens, Gillian L Schauer, Erika A Pinsker, Jasjit S Ahluwalia, Fadlo R Khuri
OBJECTIVE: We examined correlates of continued smoking versus cessation among a sample of survivors of smoking-related cancers who were actively smoking at the time of cancer diagnosis. METHODS: Participants with a history of smoking and a smoking-related cancer diagnosis (lung, oral, pharynx, larynx, esophagus, bladder, stomach, cervix, kidney, pancreas, acute myeloid leukemia) within the past 4 years were identified in the electronic medical record. We recruited 613 individuals to complete a mail-based survey and received 139 completed surveys (22...
April 2013: Psycho-oncology
Antonio Viudez-Berral, Coro Miranda-Murua, Fernando Arias-de-la-Vega, Irene Hernández-García, Alicia Artajona-Rosino, Álvaro Díaz-de-Liaño, Ruth Vera-García
Gastric cancer is a disease with high incidence and mortality in our population. The prognosis of patients with this disease is closely related to the neoplasm stage at diagnosis, including the following characteristics of the tumor: extension into the gastric wall thickness, spread to locoregional lymph nodes and the ability to generate distant metastases, as described by the TNM classification. For localized tumors characterized only by invasion of mucosa or submucosa at diagnosis, survival at 5 years is between 70 and 95% with exclusive surgical management; however, when extension into the gastric wall is higher and/or there is locoregional nodal involvement, survival decreases to 20-30% at 5 years...
March 2012: Revista Española de Enfermedades Digestivas
Kensuke Takuma, Terumi Kamisawa, Rajesh Gopalakrishna, Seiichi Hara, Taku Tabata, Yoshihiko Inaba, Naoto Egawa, Yoshinori Igarashi
Autoimmune pancreatitis (AIP) is a newly described entity of pancreatitis in which the pathogenesis appears to involve autoimmune mechanisms. Based on histological and immunohistochemical examinations of various organs of AIP patients, AIP appears to be a pancreatic lesion reflecting a systemic "IgG4-related sclerosing disease". Clinically, AIP patients and patients with pancreatic cancer share many features, such as preponderance of elderly males, frequent initial symptom of painless jaundice, development of new-onset diabetes mellitus, and elevated levels of serum tumor markers...
March 14, 2012: World Journal of Gastroenterology: WJG
Margaret H Winstanley, Iain S Pratt, Kathryn Chapman, Hayley J Griffin, Emma J Croager, Ian N Olver, Craig Sinclair, Terry J Slevin
The Cancer Council Australia (CCA) Alcohol Working Group has prepared a position statement on alcohol use and cancer. The statement has been reviewed by external experts and endorsed by the CCA Board. Alcohol use is a cause of cancer. Any level of alcohol consumption increases the risk of developing an alcohol-related cancer; the level of risk increases in line with the level of consumption. It is estimated that 5070 cases of cancer (or 5% of all cancers) are attributable to long-term chronic use of alcohol each year in Australia...
May 2, 2011: Medical Journal of Australia
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