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Troponin I

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https://www.readbyqxmd.com/read/28922671/impact-of-elevated-donor-troponin-i-as-predictor-of-adverse-outcome-in-adult-heart-transplantation-a-single-center-experience
#1
Miriam Freundt, Alois Philipp, Philipp Kolat, Leopold Rupprecht, Christine Friedrich, Stephan W Hirt, Assad Haneya
No abstract text is available yet for this article.
September 18, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28917314/evaluation-of-cardiopulmonary-and-inflammatory-markers-in-dogs-with-heartworm-infection-treated-using-the-slow-kill-method
#2
W-K Yoon, Y-W Kim, S-I Suh, C Hyun
This study evaluated the changes in the levels of cardiac, hemostatic, and inflammatory biomarkers in 12 dogs with different severities of heartworm infection treated using the slow kill protocol, consisting of 6-10μg/kg of ivermectin and 10mg/kg of doxycycline combination. The serum levels of cardiac troponin-I, D-dimer, C-reactive protein, and interleukin-6 were measured on the day of diagnosis (D0), after termination of doxycycline administration (D30), after termination of the slow kill treatment (D180), and 10 months after the initiation of therapy (D300)...
September 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28912910/prognostic-significance-of-elevated-cardiac-troponin-in-acute-gastrointestinal-bleeding
#3
Umair Iqbal, Osama Siddique, Ayesha Jameel, Hafsa Anwar, Ahmad Chaudhary
BACKGROUND: Acute gastrointestinal bleeding (AGIB) is responsible for over 140,000 hospitalizations annually. Cardiovascular-related deaths account for 30% of the patients surviving the initial episode of AGIB. The purpose of this study was to identify the impact of elevated troponin on short-term mortality and length of stay (LOS) of these patients. METHODS: From July 2013 to July 2016, 290 patients admitted with a diagnosis of AGIB and who had cardiac troponin I measured within 24 h of presentation were retrospectively reviewed...
August 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/28911512/cardioprotective-effects-of-hsp72%C3%A2-administration-on-ischemia-reperfusion-injury
#4
Takashi Tanimoto, Missag H Parseghian, Takehiro Nakahara, Hideki Kawai, Navneet Narula, Dongbin Kim, Robert Nishimura, Richard H Weisbart, Grace Chan, Richard A Richieri, Nezam Haider, Farhan Chaudhry, Glenn T Reynolds, John Billimek, Francis G Blankenberg, Partho P Sengupta, Artiom D Petrov, Takashi Akasaka, H William Strauss, Jagat Narula
BACKGROUND: Although early reperfusion is the most desirable intervention after ischemic myocardial insult, it may add to damage through oxidative stress. OBJECTIVES: This study investigated the cardioprotective effects of a single intravenous dose of heat shock protein-72 (HSP72) coupled to a single-chain variable fragment (Fv) of monoclonal antibody 3E10 (3E10Fv) in a rabbit ischemia-reperfusion model. The Fv facilitates rapid transport of HSP72 into cells, even with intact membranes...
September 19, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28906388/retrospective-cause-analysis-of-troponin-i-elevation-in-non-cad-patients-special-emphasis-on-sepsis
#5
Chien-Wen Yang, Huijun Li, Lisa Thomas, Manuel Ramos, Po-Hong Liu, Thomas Roe, Ravinder Valadri, Michael C Kiel, Vincent Yi-Fong Su, Qi Shi
BACKGROUND: Troponin I is one of the most commonly tested biochemical markers in the emergency room (ER) and in the hospital setting. Besides coronary artery disease (CAD), demand ischemia with underlying tachycardia, anemia, hypertensive emergency, congestive heart failure, kidney disease, sepsis, and pulmonary embolism have also been reported to cause troponin I elevations. Few reports have excluded patients with CAD, and no study has summarized the proportion of these factors relative to an increased troponin I level...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28904053/cardiovascular-biomarkers-in-hypertensive-patients-with-medical-treatment-results-from-the-randomized-teamsta-protect-i-trial
#6
Annika Jagodzinski, Johannes Tobias Neumann, Francisco Ojeda, Nils Arne Sörensen, Philipp Wild, Thomas Münzel, Tanja Zeller, Dirk Westermann, Stefan Blankenberg
BACKGROUND: High blood pressure (BP) is associated with an increased rate of cardiovascular events and mortality. Cardiovascular biomarkers are able to predict long-term risk in the general population, particularly in diseased cohorts. We undertook an investigation of the effect of 2 different antihypertensive treatments on cardiovascular biomarkers in a randomized trial. METHODS: The TEAMSTA study included 481 hypertensive patients. They were randomized to either 80-mg telmisartan + 5-mg amlodipine (TA) or 40-mg olmesartan + 12...
September 13, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28903763/troponin-as-ischemic-biomarker-is-related-with-all-three-echocardiographic-risk-factors-for-sudden-death-in-hypertrophic-cardiomyopathy-esc-guidelines-2014
#7
Rafał Hładij, Renata Rajtar-Salwa, Paweł Petkow Dimitrow
BACKGROUND: Sudden cardiac death (SCD) risk stratification is the most important preventive action in patients with hypertrophic cardiomyopathy (HCM). The identification of the ischemia biomarker high sensitive troponin I (hs-TnI) role for this arrhythmic disease may provide additional information for SCD risk stratification. The aim of the study was to compare echocardiographic parameters (prognostic for risk stratification of SCD in HCM) among two subgroups of HCM patients: with elevated hs-TnI versus non-elevated hs-TnI level...
September 13, 2017: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/28901167/effect-of-ischemic-postconditioning-on-myocardial-function-and-infarct-size-following-reperfusion-injury-in-diabetic-rats-pretreated-with-vildagliptin
#8
Goltaj Bayrami, Pouran Karimi, Fariba Agha-Hosseini, Saeid Feyzizadeh, Reza Badalzadeh
BACKGROUND: Cardioprotective actions of ischemic postconditioning (IPostC) against ischemia/reperfusion (I/R) injury are abolished in diabetic hearts. This study has investigated the combined effects of IPostC and vildagliptin (Vilda) on myocardial function and infarct size (IS) against I/R injury in diabetic myocardium. METHODS: Diabetes was induced by a high-fat diet/low dose of streptozotocin (35 mg/kg; intraperitoneally) in Wistar rats (200-250 g) and lasted for 12 weeks...
January 1, 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28900621/using-a-cloud-computing-system-to-reduce-door-to-balloon-time-in-acute-st-elevation-myocardial-infarction-patients-transferred-for-percutaneous-coronary-intervention
#9
Chi-Kung Ho, Fu-Cheng Chen, Yung-Lung Chen, Hui-Ting Wang, Chien-Ho Lee, Wen-Jung Chung, Cheng-Jui Lin, Shu-Kai Hsueh, Shin-Chiang Hung, Kuan-Han Wu, Chu-Feng Liu, Chia-Te Kung, Cheng-I Cheng
BACKGROUND: This study evaluated the impact on clinical outcomes using a cloud computing system to reduce percutaneous coronary intervention hospital door-to-balloon (DTB) time for ST segment elevation myocardial infarction (STEMI). METHODS: A total of 369 patients before and after implementation of the transfer protocol were enrolled. Of these patients, 262 were transferred through protocol while the other 107 patients were transferred through the traditional referral process...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28899987/heart-failure-related-hyperphosphorylation-in-the-cardiac-troponin-i-c-terminus-has-divergent-effects-on-cardiac-function-in-vivo
#10
Yuejin Li, Guangshuo Zhu, Nazareno Paolocci, Pingbo Zhang, Cyrus Takahashi, Nazli Okumus, Amir Heravi, Gizem Keceli, Genaro Ramirez-Correa, David A Kass, Anne M Murphy
BACKGROUND: In human heart failure, Ser199 (equivalent to Ser200 in mouse) of cTnI (cardiac troponin I) is significantly hyperphosphorylated, and in vitro studies suggest that it enhances myofilament calcium sensitivity and alters calpain-mediated cTnI proteolysis. However, how its hyperphosphorylation affects cardiac function in vivo remains unknown. METHODS AND RESULTS: To address the question, 2 transgenic mouse models were generated: a phospho-mimetic cTnIS200D and a phospho-silenced cTnIS200A, each driven by the cardiomyocyte-specific α-myosin heavy chain promoter...
September 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28892359/microporous-nanocomposite-enabled-microfluidic-biochip-for-cardiac-biomarker-detection
#11
Nawab Singh, Md Azahar Ali, Prabhakar Rai, Ashutosh Sharma, Bansi Dhar Malhotra, Renu John
This paper demonstrates an ultrasensitive microfluidic biochip nanoengineered with microporous manganese-reduced graphene oxide nanocomposite for detection of cardiac biomarker, namely human cardiac troponin I. In this device, the troponin sensitive microfluidic electrode consists of a thin layer of nanocomposite material manganese-reduced graphene oxide (Mn3O4-RGO). This nanocomposite thin layer has been formed on surface of a patterned indium tin oxide (ITO) substrate after modification with 3-aminopropyletriethoxysilane (APTES) and is assembled with a polydimethylsiloxane-based microfluidic system...
September 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28890872/cardiac-troponin-and-outcome-in-decompensated-heart-failure-with-preserved-ejection-fraction
#12
Mohammad Thawabi, Amer Hawatmeh, Sarah Studyvin, Habib Habib, Fayez Shamoon, Marc Cohen
BACKGROUND: Cardiac troponin (cTn) has been established as an effective prognostic marker in acute heart failure (HF) with predominantly reduced ejection fraction. However, it's prognostic value in heart failure with preserved ejection fraction (HFpEF) is unclear. The aim of this study is to describe the prognostic role of troponin I in patients hospitalized for HFpEF decompensation. METHODS: We included 363 consecutive patients admitted for HFpEF decompensation that was not associated with acute coronary syndrome (ACS)...
August 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28888177/a-label-free-cardiac-biomarker-immunosensor-based-on-phase-shifted-microfiber-bragg-grating
#13
Tong Liu, Li-Li Liang, Peng Xiao, Li-Peng Sun, Yun-Yun Huang, Yang Ran, Long Jin, Bai-Ou Guan
Fiber optics evanescent field based biosensor is an excellent candidate for label-free detection of cardiac biomarkers which is of great importance in rapid, early, and accurate diagnosis of acute myocardial infarction (AMI). In this paper, we report a compact and sensitive cardiac troponin I (cTn-I) immunosensor based on the phase-shifted microfiber Bragg grating probe which is functionalized. The fine reflective signal induced by the phase shift in modulation significantly improves the spectral resolution, enabling the ability of the sensor in perceiving an ultra-small refractive index change due to the specific capture of the cTn-I antigens...
September 4, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28888004/cardiomyocyte-coculture-on-layered-fibrous-scaffolds-assembled-from-micropatterned-electrospun-mats
#14
Yaowen Liu, Guisen Xu, Jiaojun Wei, Qiang Wu, Xiaohong Li
Challenges remain in engineering cardiac tissues with functional and morphological properties similar to those of native myocardium. In the current study, micropatterned fibrous mats are obtained by deposition of electrospun fibers on lithographic collectors to reproduce the anisotropic structure of myocardium, and carbon nanotubes are included in fibers to provide conductivities at the same level of cardiac muscles. The patterned mats are assembled layer-by-layer into patterned scaffolds for coculture of primary cardiomyocytes (CMs) with cardiac fibroblasts (CFs) and endothelial cells (ECs)...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28887702/necroptosis-may-be-a-novel-mechanism-for-cardiomyocyte-death-in-acute-myocarditis
#15
Fei Zhou, Xuejun Jiang, Lin Teng, Jun Yang, Jiawang Ding, Chao He
In this study, we investigated the roles of RIP1/RIP3 mediated cardiomyocyte necroptosis in CVB3-induced acute myocarditis. Serum concentrations of creatinine kinase (CK), CK-MB, and cardiac troponin I were detected using a Hitachi Automatic Biochemical Analyzer in a mouse model of acute VMC. Histological changes in cardiac tissue were observed by light microscope and expression levels of RIP1/RIP3 in the cardiac tissue were detected via Western blot and immunohistochemistry. The data showed that RIP1/RIP3 was highly expressed in cardiomyocytes in the acute VMC mouse model and that the necroptosis pathway specific blocker, Nec-1, dramatically reduced the myocardial damage by downregulating the expression of RIP1/RIP3...
September 8, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28884991/acute-cardiac-disease-in-a-patient-with-hyper-ige-syndrome
#16
A Castilano, H Watti, A Abdulbaki, K Modi, J A Bocchini, S L Bahna
We describe the case of a 24-year-old male with hyper-IgE syndrome (HIES) which was diagnosed at 4 years of age and died from a very rare cardiac complication. He had typical clinical and laboratory manifestations of HIES, including total serum IgE as high as > 100,000 IU/mL. Stem cell transplantation was not available. During the 20-year follow-up, he suffered numerous various infections of the skin and deep organs, partial lung resection, as well as multiple bone fractures. At age 24, he developed acute decompensated heart failure associated with elevated serum troponin I and brain natriuretic protein...
September 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28882110/serum-osteoprotegerin-in-prevalent-hemodialysis-patients-associations-with-mortality-atherosclerosis-and-cardiac-function
#17
Sílvia Collado, Elisabeth Coll, Carlos Nicolau, Manel Azqueta, Mercedes Pons, Josep M Cruzado, Bernat de la Torre, Ramón Deulofeu, Sergi Mojal, Julio Pascual, Aleix Cases
BACKGROUND: To assess whether serum osteoprotegerin (OPG) and/or fetuin-A predict mortality and cardiovascular (CV) morbidity and mortality in hemodialysis patients. METHODS: Multicenter, observational, prospective study that included 220 hemodialysis patients followed up for up to 6 years. Serum OPG and fetuin-A levels were measured at baseline and their possible association with clinical characteristics, CV risk biomarkers, carotid ultrasonographic findings, as well as their association with overall and CV mortality and CV events were assessed...
September 7, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28881400/quality-specification-and-status-of-internal-quality-control-of-cardiac-biomarkers-in-china-from-2011-to-2016
#18
Tingting Li, Wei Wang, Haijian Zhao, Falin He, Kun Zhong, Shuai Yuan, Zhiguo Wang
BACKGROUND: This study aimed to investigate the status of internal quality control (IQC) for cardiac biomarkers from 2011 to 2016 so that we can have overall knowledge of the precision level of measurements in China and set appropriate precision specifications. METHODS: Internal quality control data of cardiac biomarkers, including creatinine kinase MB (CK-MB) (μg/L), CK-MB(U/L), myoglobin (Mb), cardiac troponin I (cTnI), cardiac troponin T (cTnT), and homocysteines (HCY), were collected by a web-based external quality assessment (EQA) system...
September 7, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28879039/the-tymbal-muscle-of-cicada-has-flight-muscle-type-sarcomeric-architecture-and-protein-expression
#19
Hiroyuki Iwamoto
BACKGROUND: The structural and biochemical features of the tymbal (sound-producing) muscle of cicadas were studied by X-ray diffraction and immunochemistry, and compared with those of flight muscles from the same species. RESULTS: The X-ray diffraction pattern of the tymbal muscle was very similar to that of the dorsal longitudinal flight muscle: In both muscles, the 2,0 equatorial reflection is much more intense than the 1,1, indicating that both muscles have a flight muscle-type myofilament lattice...
2017: Zoological Letters
https://www.readbyqxmd.com/read/28878319/revisiting-myocardial-necrosis-biomarkers-assessment-of-the-effect-of-conditioning-therapies-on-infarct-size-by-kinetic-modelling
#20
David Ternant, Fabrice Ivanes, Fabrice Prunier, Nathan Mewton, Theodora Bejan-Angoulvant, Gilles Paintaud, Michel Ovize, Denis Angoulvant
Infarct size is a major predictor of subsequent cardiovascular events following ST-segment elevation myocardial infarction (STEMI) and is frequently used in clinical trials focused on cardioprotection. Approximately assessed through serial blood sampling, it can be accurately measured by imaging techniques, e.g. cardiac magnetic resonance imaging, which is the actual gold standard for infarct size determination but with limited availability in daily practice. We developed a mathematical biomarker kinetic model based on pharmacokinetic compartment models to easily and accurately estimate infarct size using individual data from five clinical trials evaluating the impact of conditioning therapies in STEMI between 2005 and 2013...
September 6, 2017: Scientific Reports
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