Christopher Livia, Sara Inglis, Ruben Crespo-Diaz, Skylar Rizzo, Ryan Mahlberg, Monique Bagwell, Matthew Hillestad, Satsuki Yamada, Dhivya Vadhana Meenakshi Siddharthan, Raman Deep Singh, Xing Li, D Kent Arrell, Paul Stalboerger, Tyra Witt, Abdallah El Sabbagh, Munveer Rihal, Charanjit Rihal, Andre Terzic, Jozef Bartunek, Atta Behfar
BACKGROUND: The purpose of this study was to investigate a therapeutic approach targeting the inflammatory response and consequent remodeling from ischemic myocardial injury. METHODS AND RESULTS: Coronary thrombus aspirates were collected from patients at the time of ST-segment-elevation myocardial infarction and subjected to array-based proteome analysis. Clinically indistinguishable at myocardial infarction (MI), patients were stratified into vulnerable and resilient on the basis of 1-year left ventricular ejection fraction and death...
May 3, 2024: Journal of the American Heart Association