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https://www.readbyqxmd.com/read/28633314/qualitative-identification-of-fentanyl-analogs-and-other-opioids-in-postmortem-cases-by-uhplc-ion-trap-msn
#1
Elisa N Shoff, M Elizabeth Zaney, Joseph H Kahl, George W Hime, Diane M Boland
Since 2013, the Miami-Dade County Medical Examiner Department has experienced an increase in the number of opioid-related deaths. The majority of cases coincided with the introduction of fentanyl into the local heroin supply. From 2014 to 2015, Miami-Dade County experienced a near 600% increase in fentanyl-related deaths, followed by an additional 200% increase in 2016. In 2015, two novel fentanyl analogs were identified in medical examiner cases: beta-hydroxythiofentanyl and acetyl fentanyl. In 2016, four additional fentanyl analogs emerged: para-fluoroisobutyryl fentanyl, butyryl fentanyl, furanyl fentanyl and carfentanil, as well as the synthetic opioid U-47700...
June 13, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28632795/sun-protection-for-infants-parent-behaviors-and-beliefs-in-miami-florida
#2
Fleta N Bray, Sebastian H Verne, Jessica Cervantes, Alexandra Balaban, Eric R Bray, Brian J Simmons, Keyvan Nouri
Children who are not adequately protected from the sun have an increased risk for developing skin cancers later in life. The primary objective of this study was to determine the sun protection behaviors that black and Hispanic parents in Miami, Florida, employ in infants younger than 6 months. Secondary objectives included determining if this patient population is at risk for infant sunburns and tanning, beliefs among parents regarding sunscreen's efficacy in the prevention of skin cancers, and limitations of sunscreen use...
May 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28627929/design-of-the-hptn-065-tlc-plus-study-a-study-to-evaluate-the-feasibility-of-an-enhanced-test-link-to-care-plus-treat-approach-for-hiv-prevention-in-the-united-states
#3
Theresa Gamble, Bernard Branson, Deborah Donnell, H Irene Hall, Georgette King, Blayne Cutler, Shannon Hader, David Burns, Jason Leider, Angela Fulwood Wood, Kevin G Volpp, Kate Buchacz, Wafaa M El-Sadr
Background/Aims HIV continues to be a major public health threat in the United States, and mathematical modeling has demonstrated that the universal effective use of antiretroviral therapy among all HIV-positive individuals (i.e. the "test and treat" approach) has the potential to control HIV. However, to accomplish this, all the steps that define the HIV care continuum must be achieved at high levels, including HIV testing and diagnosis, linkage to and retention in clinical care, antiretroviral medication initiation, and adherence to achieve and maintain viral suppression...
June 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/28625111/successful-adaptation-of-a-research-methods-course-in-south-america
#4
Leonardo Tamariz, Diego Vasquez, Cecilia Loor, Ana Palacio
BACKGROUND: South America has low research productivity. The lack of a structured research curriculum is one of the barriers to conducting research. OBJECTIVE: To report our experience adapting an active learning-based research methods curriculum to improve research productivity at a university in Ecuador. DESIGN: We used a mixed-method approach to test the adaptation of the research curriculum at Universidad Catolica Santiago de Guayaquil...
2017: Medical Education Online
https://www.readbyqxmd.com/read/28623074/geographic-variability-in-gestational-weight-gain-a-multilevel-population-based-study-of-women-having-term-births-in-florida-2005-2012
#5
Maya Tabet, Erik Nelson, Mario Schootman, Lung-Chang Chien, Jen Jen Chang
PURPOSE: We examined the extent of geographic variability in gestational weight gain (GWG), identified areas where women have suboptimal GWG, and evaluated whether individual- and area-level factors account for such variability. METHODS: We conducted a population-based cohort study including 1,385,574 women delivering term, singleton, and live births in Florida. We used a Bayesian, structured additive regression with a spatial function to analyze data from Florida's birth certificates (2005-2012) and ZIP code tabulation areas (ZCTAs; 2010 Census)...
June 1, 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/28621178/interview-with-bernard-siegel
#6
Bernard Siegel
Bernard Siegel is the Founder and full-time Executive Director of the nonprofit Regenerative Medicine Foundation (FL, USA). He is the Founder and the Co-chair of the World Stem Cell Summit series of global conferences and Editor-in-Chief of the World Stem Cell Report. He received his undergraduate and law degrees from the University of Miami (BA, 1972; JD, 1975) and has been a member of the Florida Bar since 1975. As a recognized policy expert relating to stem cell research, regenerative medicine and cloning, Bernard works with the world's leading stem cell researchers and advocates...
June 16, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28614156/endothelial-cell-loss-in-diabetic-and-nondiabetic-eyes-after-cataract-surgery
#7
Xu He, Vasilios F Diakonis, Yasamin Alavi, Nilufer Yesilirmak, Daniel Waren, Kendall Donaldson
PURPOSE: To assess and compare the changes in endothelial cell density in diabetic and nondiabetic patients after routine phacoemulsification cataract surgery. SETTING: Bascom Palmer Eye Institute, Miller School of Medicine, Miami, FL, USA. DESIGN: Retrospective nonrandomized cohort study. METHODS: This retrospective study included diabetic and nondiabetic patients who underwent phacoemulsification by a single surgeon (K...
June 13, 2017: Cornea
https://www.readbyqxmd.com/read/28613924/spirometry-reference-equations-from-the-hispanic-community-health-study-study-of-latinos-hchs-sol
#8
Lisa LaVange, Sonia M Davis, John Hankinson, Paul Enright, Rebbecca Wilson, R Graham Barr, Thomas K Aldrich, Ravi Kalhan, Hector Lemus, Ai Ni, Lewis J Smith, Gregory A Talavera
RATIONALE: Accurate reference values for spirometry are important, as the results are used for diagnosing common chronic lung diseases such as asthma and chronic obstructive pulmonary disease, estimating physiological impairment, and predicting all-cause mortality. Reference equations have been established for Mexican Americans but not for other Hispanic/Latino backgrounds. OBJECTIVES: To develop spirometry reference equations for adult Hispanic/Latino background groups in the United States...
June 14, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28611994/common-allergens-identified-based-on-patch-test-results-in-patients-with-suspected-contact-dermatitis-of-the-scalp
#9
Nouf M Aleid, Raymond Fertig, Austin Maddy, Antonella Tosti
BACKGROUND: Contact dermatitis of the scalp is common and might be caused by many chemicals including metals, ingredients of shampoos and conditioners, dyes, or other hair treatments. Eliciting a careful history and patch tests are necessary to identify the responsible allergen and prevent relapses. OBJECTIVES: To identify allergens that may cause contact dermatitis of the scalp by reviewing patch test results. METHODS: We reviewed the records of 1,015 patients referred for patch testing at the Dermatology Department of the University of Miami...
March 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/28604442/awareness-willingness-and-use-of-pre-exposure-prophylaxis-among-men-who-have-sex-with-men-in-washington-dc-and-miami-dade-county-fl-national-hiv-behavioral-surveillance-2011-and-2014
#10
Rudy Patrick, David Forrest, Gabriel Cardenas, Jenevieve Opoku, Manya Magnus, Gregory Phillips, Alan Greenberg, Lisa Metsch, Michael Kharfen, Marlene LaLota, Irene Kuo
INTRODUCTION: Despite the effectiveness of oral pre-exposure prophylaxis (PrEP) for HIV prevention, knowledge, and uptake of this new prevention intervention over time has not been fully studied. Using NHBS data from 2 urban areas highly impacted by HIV, we examined awareness, use, and willingness to use daily oral PrEP and factors associated with willingness to take oral PrEP among men who have sex with men (MSM) over time. METHODS: MSM from Washington, DC and Miami, FL were recruited in 2011 and 2014 using venue-based sampling...
July 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28595734/ethics-big-data-and-computing-in-epidemiology-and-public-health
#11
Jennifer Salerno, Bartha M Knoppers, Lisa M Lee, WayWay M Hlaing, Kenneth W Goodman
PURPOSE: This article reflects on the activities of the Ethics Committee of the American College of Epidemiology (ACE). Members of the Ethics Committee identified an opportunity to elaborate on knowledge gained since the inception of the original Ethics Guidelines published by the ACE Ethics and Standards of Practice Committee in 2000. METHODS: The ACE Ethics Committee presented a symposium session at the 2016 Epidemiology Congress of the Americas in Miami on the evolving complexities of ethics and epidemiology as it pertains to "big data...
May 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/28578756/sexual-risk-behaviours-associated-with-unlicensed-driving-among-young-adults-in-miami
#12
Mance E Buttram, Steven P Kurtz, Roddia J Paul
Literature indicates that unlicensed driving (UD) offenders report substance use risk behaviours, yet data related to sexual risk behaviours is unknown. This study examined sexual and other risk behaviours among young adults in Miami, Florida, comparing UD and non-UD offenders (n=498). Compared with others, UD offenders were more likely to report group sex history, being high for sex half the time or more, purchasing sex and sexually transmissible infection history. Results suggest that locating sexual risk reduction interventions inside of the justice system would benefit UD offenders...
June 5, 2017: Sexual Health
https://www.readbyqxmd.com/read/28575217/comprehensive-platelet-phenotypic-laboratory-testing-and-bleeding-history-scoring-for-diagnosis-of-suspected-hereditary-platelet-disorders-a-single-institution-experience
#13
Juliana Perez Botero, Deepti M Warad, Rong He, Cindy B Uhl, Shulan Tian, Gregory E Otteson, Ryan L Barness, Mary C Olson, Susan C Gossman, Jon E Charlesworth, William L Nichols, Rajiv K Pruthi, Dong Chen
Objectives: Patients with hereditary/congenital platelet disorders (HPDs) have a broad range of clinical manifestations and laboratory phenotypes. We assessed the performance characteristics of the International Society on Thrombosis and Haemostasis bleeding assessment tool (ISTH-BAT) and clinically validated platelet laboratory tests for diagnosis of HPDs. Methods: The records of 61 patients with suspected HPDs were reviewed and ISTH-BAT scores calculated. Results: Nineteen (31%) patients had thrombocytopenia, and 46 (75%) had positive ISTH-BAT scores...
June 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28554394/from-transplanting-schwann-cells-in-experimental-rat-spinal-cord-injury-to-their-transplantation-into-human-injured-spinal-cord-in-clinical-trials
#14
Mary B Bunge, Paula V Monje, Aisha Khan, Patrick M Wood
Among the potential therapies designed to repair the injured spinal cord is cell transplantation, notably the use of autologous adult human Schwann cells (SCs). Here, we detail some of the critical research accomplished over the last four decades to establish a foundation that enables these cells to be tested in clinical trials. New culture systems allowed novel information to be gained about SCs, including discovering ways to stimulate their proliferation to acquire adequately large numbers for transplantation into the injured human spinal cord...
2017: Progress in Brain Research
https://www.readbyqxmd.com/read/28546690/update-on-the-epidemiology-and-antibiotic-resistance-of-ocular-infections
#15
Darlene Miller
PURPOSE: The purpose of this review is to provide an update on the epidemiology and current antibiotic-resistant threats in ophthalmology. METHODS: Trends in frequency and antibiotic-nonsusceptible profiles during an 11 year-period (2005-2015) were evaluated and compared with the 5-year Antibiotic Resistance Monitoring in Ocular Microorganism (ARMOR) study. RESULTS: Trends in the current review confirmed the continued high rates of fluoroquinolone nonsusceptbility circulating among ocular methicillin-susceptible Staphylococcus aureus, methicillin-susceptible Staphylococcus epidermidis, methicillin-resistant S...
January 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28538723/genomic-epidemiology-reveals-multiple-introductions-of-zika-virus-into-the-united-states
#16
Nathan D Grubaugh, Jason T Ladner, Moritz U G Kraemer, Gytis Dudas, Amanda L Tan, Karthik Gangavarapu, Michael R Wiley, Stephen White, Julien Thézé, Diogo M Magnani, Karla Prieto, Daniel Reyes, Andrea M Bingham, Lauren M Paul, Refugio Robles-Sikisaka, Glenn Oliveira, Darryl Pronty, Carolyn M Barcellona, Hayden C Metsky, Mary Lynn Baniecki, Kayla G Barnes, Bridget Chak, Catherine A Freije, Adrianne Gladden-Young, Andreas Gnirke, Cynthia Luo, Bronwyn MacInnis, Christian B Matranga, Daniel J Park, James Qu, Stephen F Schaffner, Christopher Tomkins-Tinch, Kendra L West, Sarah M Winnicki, Shirlee Wohl, Nathan L Yozwiak, Joshua Quick, Joseph R Fauver, Kamran Khan, Shannon E Brent, Robert C Reiner, Paola N Lichtenberger, Michael J Ricciardi, Varian K Bailey, David I Watkins, Marshall R Cone, Edgar W Kopp, Kelly N Hogan, Andrew C Cannons, Reynald Jean, Andrew J Monaghan, Robert F Garry, Nicholas J Loman, Nuno R Faria, Mario C Porcelli, Chalmers Vasquez, Elyse R Nagle, Derek A T Cummings, Danielle Stanek, Andrew Rambaut, Mariano Sanchez-Lockhart, Pardis C Sabeti, Leah D Gillis, Scott F Michael, Trevor Bedford, Oliver G Pybus, Sharon Isern, Gustavo Palacios, Kristian G Andersen
Zika virus (ZIKV) is causing an unprecedented epidemic linked to severe congenital abnormalities. In July 2016, mosquito-borne ZIKV transmission was reported in the continental United States; since then, hundreds of locally acquired infections have been reported in Florida. To gain insights into the timing, source, and likely route(s) of ZIKV introduction, we tracked the virus from its first detection in Florida by sequencing ZIKV genomes from infected patients and Aedes aegypti mosquitoes. We show that at least 4 introductions, but potentially as many as 40, contributed to the outbreak in Florida and that local transmission is likely to have started in the spring of 2016-several months before its initial detection...
June 15, 2017: Nature
https://www.readbyqxmd.com/read/28528807/comparison-of-amicus-and-cobe-spectra-for-allogenic-peripheral-blood-stem-cell-harvest-study-from-tertiary-care-centre-in-india
#17
Rasika Dhawan Setia, Satyam Arora, Anil Handoo, Tina Dadu, Dharma Choudhary, Sajeev Kumar Sharma, Gaurav Kharya, Vipin Khandelwal, Prerna Sachdeva, Divya Doval, Anamika Bakliwal, Meenu Kapoor, Shalu Bajaj, Virendra Bachchas, Praveen Singh
INTRODUCTION: Most common source of stem cell graft for both autologous and allogenic haematopoietic transplants are peripheral blood haematopoietic progenitor stem cells. Adequate collection of the CD34+ cells and safety of the allogenic donor during the leukapheresis are of prime importance to an apheresis physician. Our retrospective analysis is a comparison between of two platforms namely, COBE Spectra and Amicus, for CD34+ mononuclear cell collection. MATERIAL AND METHOD: The study included the data of GSCF (Granulocyte-Colony-Stimulating Factor) mobilized allogenic PBSC collections at our centre from January 2015 to June 2016...
April 24, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28525510/zika-virus-obstetric-and-pediatric-anesthesia-considerations
#18
Jacqueline L Tutiven, Benjamin T Pruden, James S Banks, Mario Stevenson, David J Birnbach
As of November 2016, the Florida Department of Health (FDH) and the Centers for Disease Control and Prevention have confirmed more than 4000 travel-related Zika virus (ZIKV) infections in the United States with >700 of those in Florida. There have been 139 cases of locally acquired infection, all occurring in Miami, Florida. Within the US territories (eg, Puerto Rico, US Virgin Islands), >30,000 cases of ZIKV infection have been reported. The projected number of individuals at risk for ZIKV infection in the Caribbean and Latin America approximates 5 million...
June 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28508675/serious-mental-illness-among-young-adult-women-who-use-drugs-in-the-club-scene-co-occurring-biopsychosocial-factors
#19
Maayan Lawental, Hilary L Surratt, Mance E Buttram, Steven P Kurtz
Young women who regularly attend nightclubs are at risk for numerous health and social consequences, including mental distress, sexual and physical victimization and substance dependence. This paper uses a biopsychosocial framework to examine co-occurring mental health problems, victimization, substance dependence, sexual risk and physical pain among a sample of young women who use drugs (N = 222) in Miami's club scene. The majority of women were under 24 years old, Hispanic, and identified as heterosexual...
May 16, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28506604/the-supraciliary-space-as-a-suitable-pathway-for-glaucoma-surgery-ho-hum-or-home-run
#20
REVIEW
Michele Figus, Chiara Posarelli, Andrea Passani, Timothy G Albert, Francesco Oddone, Angela Tindara Sframeli, Marco Nardi
The supraciliary space is a physiological route for aqueous humor outflow located anteriorly between the outer surface of the ciliary body and the internal surface of the sclera. Posteriorly, the suprachoroidal space is located between the choroid and the internal surface of the sclera. These spaces have been targeted as suitable and helpful pathways for glaucoma treatment, alternatives to the traditional subconjunctival space. The subconjunctival surgical pathway is affected by several limitations such as poor cosmesis, a lifetime risk for endophthalmitis, and an unpredictable wound healing response...
May 12, 2017: Survey of Ophthalmology
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