keyword
https://read.qxmd.com/read/38525412/advances-in-human-centered-care-to-address-contemporary-unmet-needs-in-chronic-dialysis
#21
REVIEW
Sumedh Jayanti, Gopala K Rangan
Advances in the treatment of kidney failure with chronic dialysis have stagnated over the past three decades, with over 50% of patients still managed by conventional in-hospital haemodialysis. In parallel, the demands of chronic dialysis medical care have changed and evolved due to a growing population that has higher frailty and multimorbidity. Thus, the gap between the needs of kidney failure patients and the healthcare capability to provide effective overall management has widened. To address this problem, healthcare policy has increasingly aligned towards a human-centred approach...
2024: International Journal of Nephrology and Renovascular Disease
https://read.qxmd.com/read/38524160/association-between-chronic-kidney-disease-and-restless-leg-syndrome-rls-a-systematic-review-and-meta-analysis
#22
JOURNAL ARTICLE
Nur Aini, Ollyvia Freeska Dwi Marta, Erma Wahyu Mashfufa, Lilis Setyowati
UNLABELLED: Restless leg syndrome (RLS) is characterized by unpleasant nocturnal sensations in the lower limbs, and it has emerged as the fourth leading cause of insomnia and is often an underdiagnosed medical condition among sleep disorders. The symptoms of RLS are more common in chronic kidney disease patients than in the general population. Therefore, we performed the first meta-analysis to estimate the risk of RLS among chronic kidney disease patients. We conducted a comprehensive search in Embase, Ovid-MEDLINE, PubMed, Scopus, Web of Science, and CINAHL databases...
April 2024: Sleep and Biological Rhythms
https://read.qxmd.com/read/38524037/altered-mental-status-in-the-setting-of-thrombotic-thrombocytopenic-purpura-ttp-and-spontaneous-coronary-artery-dissection-scad-a-case-report-and-literature-review
#23
Esmirna Perez, Nehemias Guevara, Jordan Smith, Ricardo Velasquez
Altered mental status (AMS) is a common condition encountered in daily practice. Finding the cause is essential for treatment, but sometimes this may be challenging. Spontaneous coronary artery dissection (SCAD) is frequently underdiagnosed and is a potentially fatal cause of acute coronary syndrome. Clinical presentation depends on the extent of SCAD, ranging from unstable angina to sudden death. AMS has not been reported with this condition, but it may be possible in hypoperfusion states. Thrombotic thrombocytopenic purpura (TTP) is part of the microangiopathic hemolytic anemia (MAHA) spectrum, presenting with AMS as the cardinal symptom...
February 2024: Curēus
https://read.qxmd.com/read/38523999/filling-in-the-gaps-ethylene-glycol-poisoning-presenting-with-isolated-lactate-and-osmolar-gaps
#24
Caden Quintanilla, Justin Panthappattu, Davood Hosseini, Karan Omidvari
Ethylene glycol (EG) is an organic compound used in antifreeze. In 2020 alone, there were 5,277 EG exposures, with only 617 reported as intentional ingestions. Therefore, encountering EG toxicity is rare; however, it is essential to identify it promptly based on a focused history, exam, and rapid identification of commonly associated EG-induced metabolic derangements. If the diagnosis is not made within 12 hours of ingestion or exposure, severe morbidity and mortality can occur. Previous reports of EG poisoning have occurred in the setting of a lactate gap (LG) and osmolar gap (OG); however, they also had commonly associated findings of EG toxicity such as high anion gap acidosis (HAGMA), acute kidney injury (AKI), hypocalcemia, calcium oxalate stones, and suggestive histories of EG ingestion...
February 2024: Curēus
https://read.qxmd.com/read/38523818/urethral-meatus-edema-with-peno-scrotal-edema-in-a-patient-with-transfusion-dependent-beta-thalassemia-major
#25
Oussama G Nasrallah, Jana H Mahdi, Bassel G Bachir
Urethral meatus edema is a rare finding and may infer a more severe form of volume overload. Management of patients with thalassemia vary in terms of the severity of the kidney injury due to transfusion, chronicity, and severity of volume overload.
March 2024: Clinical Case Reports
https://read.qxmd.com/read/38522017/health-literacy-self-efficacy-and-health-outcomes-of-patients-undergoing-haemodialysis-mediating-role-of-self-management
#26
JOURNAL ARTICLE
Shu-Hua Hsu, Yu-Li Lin, Malcolm Koo, Debra K Creedy, Ying Tsao
BACKGROUND: Health literacy, self-efficacy and self-management are known to influence health-related well-being. However, the precise influence of self-management, health literacy and self-efficacy on health outcomes in Asian countries is under-researched. OBJECTIVES: To examine the impact of health literacy and self-efficacy (independent variables) and self-management (mediator) on patients' health outcomes (dependent variable). DESIGN: An observational, cross-sectional design was conducted between 1 March 2022 and 31 August 2022...
March 24, 2024: Journal of Renal Care
https://read.qxmd.com/read/38521380/associations-between-dietary-patterns-and-kidney-health-assessed-in-the-population-based-chris-study-using-reduced-rank-regression
#27
JOURNAL ARTICLE
Giulia Barbieri, Vanessa Garcia-Larsen, Rebecca Lundin, Ryosuke Fujii, Roberto Melotti, Martin Gögele, Kenneth B Christopher, Lucia Cazzoletti, Peter P Pramstaller, Maria Elisabetta Zanolin, Cristian Pattaro, Essi Hantikainen
OBJECTIVE: While diet plays a key role in CKD management, the potential for diet to impact CKD prevention in the general population is less clear. Using a priori knowledge, we derived disease-related dietary patterns (DPs) through reduced rank regression (RRR) and investigated associations with kidney function, separately focusing on generally healthy individuals and those with self-reported kidney diseases, hypertension or diabetes mellitus. METHODS: 8,686 participants from the population-based Cooperative Health Research in South Tyrol (CHRIS) study were split into a group free of kidney disease, hypertension and diabetes (n=6,133) and a group with any of the three conditions (n=2,553)...
March 21, 2024: Journal of Renal Nutrition
https://read.qxmd.com/read/38519947/machine-learning-models-for-predicting-the-onset-of-chronic-kidney-disease-after-surgery-in-patients-with-renal-cell-carcinoma
#28
JOURNAL ARTICLE
Seol Whan Oh, Seok-Soo Byun, Jung Kwon Kim, Chang Wook Jeong, Cheol Kwak, Eu Chang Hwang, Seok Ho Kang, Jinsoo Chung, Yong-June Kim, Yun-Sok Ha, Sung-Hoo Hong
BACKGROUND: Patients with renal cell carcinoma (RCC) have an elevated risk of chronic kidney disease (CKD) following nephrectomy. Therefore, continuous monitoring and subsequent interventions are necessary. It is recommended to evaluate renal function postoperatively. Therefore, a tool to predict CKD onset is essential for postoperative follow-up and management. METHODS: We constructed a cohort using data from eight tertiary hospitals from the Korean Renal Cell Carcinoma (KORCC) database...
March 22, 2024: BMC Medical Informatics and Decision Making
https://read.qxmd.com/read/38519239/executive-summary-of-the-kdigo-2024-clinical-practice-guideline-for-the-evaluation-and-management-of-chronic-kidney-disease-known-knowns-and-known-unknowns
#29
Adeera Levin, Sofia B Ahmed, Juan Jesus Carrero, Bethany Foster, Anna Francis, Rasheeda K Hall, Will G Herrington, Guy Hill, Lesley A Inker, Rümeyza Kazancıoğlu, Edmund Lamb, Peter Lin, Magdalena Madero, Natasha McIntyre, Kelly Morrow, Glenda Roberts, Dharshana Sabanayagam, Elke Schaeffner, Michael Shlipak, Rukshana Shroff, Navdeep Tangri, Teerawat Thanachayanont, Ifeoma Ulasi, Germaine Wong, Chih-Wei Yang, Luxia Zhang, Karen A Robinson, Lisa Wilson, Renee F Wilson, Bertram L Kasiske, Michael Cheung, Amy Earley, Paul E Stevens
The Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease (CKD) updates the KDIGO 2012 guideline and has been developed with patient partners, clinicians, and researchers around the world, using robust methodology. This update, based on a substantially broader base of evidence than has previously been available, reflects an exciting time in nephrology. New therapies and strategies have been tested in large and diverse populations that help to inform care; however, this guideline is not intended for people receiving dialysis nor those who have a kidney transplant...
April 2024: Kidney International
https://read.qxmd.com/read/38519235/integrating-essence-of-time-for-blood-pressure-control-in-nephrology-care
#30
REVIEW
Yejin Mok, Kunihiro Matsushita
Controlling blood pressure (BP) is essential in the management of patients with chronic kidney disease. Reflecting the intrinsic variability of BP, several parameters of BP over time have been shown to predict adverse outcomes. Systolic BP time in target range has been recently proposed as a new promising parameter. Park et al. confirmed its prognostic value in patients with chronic kidney disease. We review the potential clinical usefulness and challenges of this parameter in nephrology care.
April 2024: Kidney International
https://read.qxmd.com/read/38518063/interventions-for-pancreatitis-new-approaches-knowledge-gaps-and-research-opportunities-summary-of-a-national-institute-of-diabetes-and-digestive-and-kidney-diseases-workshop
#31
JOURNAL ARTICLE
Anna Evans Phillips, Steven J Hughes, Dana K Andersen, Adam Bell, Randall Brand, Gregory A Coté, Adriana Cowdin, Nancy Diazgranados, Vikas Dudeja, Sinead N Duggan, Evan Fogel, Chris E Forsmark, A Jay Freeman, George Gittes, Phil A Hart, Christie Jeon, William Nealon, John Neoptolemos, Tonya M Palermo, Stephen Pandol, Kristen M Roberts, Martin Rosenthal, Vikesh K Singh, Dhiraj Yadav, David C Whitcomb, Nicholas Zyromski
There exists no cure for acute, recurrent acute or chronic pancreatitis and treatments to date have been focused on managing symptoms. A recent workshop held by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) focused on interventions that might disrupt or perhaps even reverse the natural course of this heterogenous disease, aiming to identify knowledge gaps and research opportunities that might inform future funding initiatives for NIDDK. The breadth and variety of identified active or planned clinical trials traverses the spectrum of the disease and was conceptually grouped for the workshop into behavioral, nutritional, pharmacologic and biologic, and mechanical interventions...
April 1, 2024: Pancreas
https://read.qxmd.com/read/38517440/concomitant-use-of-selective-serotonin-reuptake-inhibitors-with-oral-anticoagulants-and-risk-of-major-bleeding
#32
JOURNAL ARTICLE
Alvi A Rahman, Robert W Platt, Sarah Beradid, Jean-François Boivin, Soham Rej, Christel Renoux
IMPORTANCE: Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed antidepressants associated with a small increased risk of major bleeding. However, the risk of bleeding associated with the concomitant use of SSRIs and oral anticoagulants (OACs) has not been well characterized. OBJECTIVES: To assess whether concomitant use of SSRIs with OACs is associated with an increased risk of major bleeding compared with OAC use alone, describe how the risk varies with duration of use, and identify key clinical characteristics modifying this risk...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38517436/enrollment-in-high-deductible-health-plans-and-incident-diabetes-complications
#33
JOURNAL ARTICLE
Rozalina G McCoy, Kavya S Swarna, David H Jiang, Holly K Van Houten, Jie Chen, Esa M Davis, Jeph Herrin
IMPORTANCE: Preventing diabetes complications requires monitoring and control of hyperglycemia and cardiovascular risk factors. Switching to high-deductible health plans (HDHPs) has been shown to hinder aspects of diabetes care; however, the association of HDHP enrollment with microvascular and macrovascular diabetes complications is unknown. OBJECTIVE: To examine the association between an employer-required switch to an HDHP and incident complications of diabetes...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38517337/sodium-glucose-cotransporter-2-inhibitors-are-they-ready-for-prime-time-in-the-management-of-lupus-nephritis
#34
JOURNAL ARTICLE
Benjamin R Wagner, Panduranga S Rao
PURPOSE OF REVIEW: Lupus nephritis is a common complication of systemic lupus erythematosus and is associated with significant morbidity and mortality. The utility of sodium-glucose cotransporter 2 (SGLT2) inhibitors in the management of lupus nephritis is currently uncertain. Here, we summarize the rationale for their use among patient with lupus nephritis. RECENT FINDINGS: SGLT2 inhibitors were initially developed as antihyperglycemic agents. They have since been shown to have additional, profound effects to slow the progression of chronic kidney disease and lessen the long-term risks of cardiovascular disease in large clinic trials of patients with chronic kidney disease, with and without diabetes, as well as in patients with and without proteinuria...
May 1, 2024: Current Opinion in Rheumatology
https://read.qxmd.com/read/38516472/nephrological-detrimental-impacts-resulting-from-novel-immunotherapy-drugs-used-in-the-treatment-of-cancer-a-systematic-review
#35
REVIEW
Amisha Jaiswal, Kainaat Shergill, Kusalik Boppana, Naiela E Almansouri, Saloni Bakkannavar, Youmna Faheem, Tuheen Sankar Nath
The most recent advancements in cancer therapy center on efficiently and conveniently enhancing a patient's natural immune system. Immune checkpoint inhibitors (ICIs) are antibodies that target cytotoxic thymus (T) lymphocyte antigen-4 (CTLA-4) and its receptor. They function by stimulating T-cell activity against malignancies. Immune-related adverse events (irAEs) are a distinct class of inflammatory side effects that are specific to a given organ. Antineoplastic medications can impact any part of the kidney, leading to the development of proteinuria, hypertension, electrolyte abnormalities, glomerulonephritis, and both acute and chronic interstitial nephritis...
February 2024: Curēus
https://read.qxmd.com/read/38515853/ferric-citrate-for-the-treatment-of-hyperphosphatemia-and-iron-deficiency-anaemia-in-patients-with-ndd-ckd-a-systematic-review-and-meta-analysis
#36
REVIEW
Xueying Ding, Shujie Sun, Jinjin Zhang, Huifang Zhao, Fenglan Lun, Xuemin Liu, Yiwan Zhen, Jinping Dong, Jingliang Wu
Background: The application of ferric citrate therapy has yielded unexpected benefits in recent years for Chronic kidney disease patients suffering from hyperphosphatemia and iron deficiency -anaemia. Despite this, earlier research on the impact of ferric citrate on NDD-CKD has been contentious. Objective: The goal of the meta-analysis is to evaluate the evidence regarding the advantages and dangers of ferric citrate for the treatment of hyperphosphatemia and iron deficiency anaemia in NDD-CKD patients. Methods: Between the start of the study and June 2022, we searched PubMed, Embase, Cochrane, EBSCO, Scopus, Web of Science, Wan Fang Data, CNKI, and VIP databases for randomised controlled trials of iron citrate for hyperphosphatemia and anaemia in patients with NDD-CKD...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38513618/management-of-hyperkalemia-in-raasi-strategies-to-maintain-chronic-kidney-disease-patients-with-type-ii-diabetes-on-therapy
#37
REVIEW
Humaira A Mahmud, Biff F Palmer
BACKGROUND: According to the Centers for Disease Control and Prevention (CDC), diabetes affects approximately 37.3 million individuals in the United States (US), with another estimated 96 million people having a prediabetic state. Furthermore, one or two out of three adult Americans exhibit metabolic syndrome or an insulin-resistant state, depending on their age group. SUMMARY: Chronic Kidney Disease (CKD) represents a complication often associated with T2D or the insulin-resistant condition, typically identifiable through proteinuria...
March 21, 2024: Cardiorenal Medicine
https://read.qxmd.com/read/38512418/evaluation-of-management-of-ct-scan-proved-solid-organ-injury-in-blunt-injury-abdomen-a-prospective-study
#38
JOURNAL ARTICLE
Sourodip Mukharjee, Dinesh B V, Bharath S V
BACKGROUND: Trauma especially road traffic injury is one of the major health-related issues throughout the world, especially in developing countries like India (Mattox 2022). Solid organ injury is the most common cause of morbidity and mortality in patients with blunt abdominal trauma. The non-operative management (NOM) is being consistently followed for hemodynamically stable patients with respect to solid organ injuries. This study aims to provide an evidence base for management modalities of solid organ injuries in blunt abdominal trauma...
March 21, 2024: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://read.qxmd.com/read/38512380/association-of-mental-health-related-patient-reported-outcomes-with-blood-pressure-in-adults-and-children-with-primary-proteinuric-glomerulopathies
#39
JOURNAL ARTICLE
Matthew Schuchman, Tammy M Brady, Dorey A Glenn, Katherine R Tuttle, Gabriel Cara-Fuentes, Rebecca V Levy, Agustin Gonzalez-Vicente, Fadhl M Alakwaa, Tarak Srivastava, Christine B Sethna
INTRODUCTION: The prevalence of mental health disorders including anxiety and depression is increasing and is linked to hypertension in healthy individuals. However, the relationship of psychosocial patient-reported outcomes on blood pressure (BP) in primary proteinuric glomerulopathies is not well characterized. This study explored longitudinal relationships between psychosocial patient-reported outcomes and BP status among individuals with proteinuric glomerulopathies. METHODS: An observational cohort study was performed using data from 745 adults and children enrolled in the Nephrotic Syndrome Study Network (NEPTUNE)...
March 21, 2024: Journal of Nephrology
https://read.qxmd.com/read/38512368/the-predictive-value-of-systemic-inflammatory-markers-in-902-patients-with-tunneled-hemodialysis-catheter
#40
JOURNAL ARTICLE
Melis Baykara Ulusan, Emine Meltem, Ilhan Nahit Mutlu, Kivilcim Ulusan
AIM: This study aimed to assess the predictive role of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and mean platelet volume, on catheter survival in chronic hemodialysis patients, analyzing both infectious and non-infectious complications. METHODS: A retrospective analysis encompassed 1279 tunneled catheter insertion procedures involving 902 patients between March 2014 and October 2018. Patients were categorized into two main groups: (i) initial placement and (ii) exchange...
March 21, 2024: Journal of Nephrology
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