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https://www.readbyqxmd.com/read/29917248/population-variability-in-animal-health-influence-on-dose-exposure-response-relationships-part-i-drug-metabolism-and-transporter-systems
#1
Marilyn N Martinez, Michael H Court, Johanna Fink-Gremmels, Katrina L Mealey
There is an increasing effort to understand the many sources of population variability that can influence drug absorption, metabolism, disposition, and clearance in veterinary species. This growing interest reflects the recognition that this diversity can influence dose-exposure-response relationships and can affect the drug residues present in the edible tissues of food-producing animals. To appreciate the pharmacokinetic diversity that may exist across a population of potential drug product recipients, both endogenous and exogenous variables need to be considered...
June 19, 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29917224/examining-the-effectiveness-of-an-intensive-2-week-treatment-program-for-military-personnel-and-veterans-with-ptsd-results-of-a-pilot-open-label-prospective-cohort-trial
#2
Craig J Bryan, Feea R Leifker, David C Rozek, AnnaBelle O Bryan, Mira L Reynolds, D Nicolas Oakey, Erika Roberge
OBJECTIVE: This study aimed to examine the effectiveness of cognitive processing therapy (CPT) for posttraumatic stress disorder (PTSD) when administered on a daily basis during a 2-week period of time. METHOD: In an open-label, prospective cohort pilot trial, 20 U.S. military personnel and veterans diagnosed with PTSD or subthreshold PTSD participated in 12 daily sessions of CPT. Primary outcomes included Clinician Administered PTSD Scale for DSM-5 and PTSD Checklist for DSM-5 scores...
June 19, 2018: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29916803/genome-analysis-of-methicillin-resistance-in-macrococcus-caseolyticus-from-dairy-cattle-in-england-and-wales
#3
Alison C MacFadyen, Elizabeth A Fisher, Ben Costa, Cassie Cullen, Gavin K Paterson
Species of the genus Macrococcus are widespread commensals of animals but are becoming increasingly recognised as veterinary pathogens. They can encode methicillin resistance and are implicated in its spread to the closely-related, but more pathogenic, staphylococci. In this study we have identified 33 isolates of methicillin-resistant Macrococcus caseolyticus from bovine bulk tank milk from England and Wales. These isolates were characterised to provide insight into the molecular epidemiology of M. caseolyticus and to discern the genetic basis for their methicillin resistance...
June 19, 2018: Microbial Genomics
https://www.readbyqxmd.com/read/29916349/antimicrobial-stewardship-in-veterinary-medicine
#4
David H Lloyd, Stephen W Page
While antimicrobial resistance is already a public health crisis in human medicine, therapeutic failure in veterinary medicine due to antimicrobial resistance remains relatively uncommon. However, there are many pathways by which antimicrobial resistance determinants can travel between animals and humans: by close contact, through the food chain, or indirectly via the environment. Antimicrobial stewardship describes measures that can help mitigate the public health crisis and preserve the effectiveness of available antimicrobial agents...
May 2018: Microbiology Spectrum
https://www.readbyqxmd.com/read/29916344/antimicrobial-resistance-in-pasteurellaceae-of-veterinary-origin
#5
Geovana B Michael, Janine T Bossé, Stefan Schwarz
Members of the highly heterogeneous family Pasteurellaceae cause a wide variety of diseases in humans and animals. Antimicrobial agents are the most powerful tools to control such infections. However, the acquisition of resistance genes, as well as the development of resistance-mediating mutations, significantly reduces the efficacy of the antimicrobial agents. This article gives a brief description of the role of selected members of the family Pasteurellaceae in animal infections and of the most recent data on the susceptibility status of such members...
May 2018: Microbiology Spectrum
https://www.readbyqxmd.com/read/29916326/transformative-relationships-humans-and-animals
#6
Pamela N Clarke
This column focuses on the transformative nature of human-animal relationships. In the context of nursing, these relationships are clearly therapeutic for veterans recovering from trauma. The time is right to begin to explore the science behind such unique healing relationships and the potential connection to nursing science.
July 2018: Nursing Science Quarterly
https://www.readbyqxmd.com/read/29916276/association-of-estrogen-progesterone-and-follicle-stimulating-hormone-receptor-polymorphisms-with-in-vitro-fertilization-outcomes
#7
Vijaya Ganesh, Vettriselvi Venkatesan, Teena Koshy, Sanjeeva Nellapalli Reddy, Suruli Muthumuthiah, Solomon Franklin Durairaj Paul
Despite the advances in in vitro fertilization (IVF), the implantation success rate for infertile women remains approximately only 15%. In this study, we sought to determine whether implantation failure after repeated IVF treatments is influenced by the presence of common variants in estrogen α, progesterone and follicle stimulating hormone receptor genes. The study population included three groups of women: group 1 were 50 women who had the transfer of ≥3 high-quality embryos during the IVF procedure without ever having had a clinical pregnancy; group 2 were 50 women who achieved a clinical pregnancy after ≤3 high-quality embryos transfers and group 3 were 50 control subjects who achieved a clinical pregnancy without any fertility therapy that resulted in a one live-born infant...
June 19, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29916033/-development-through-encounter-kurt-goldstein-s-contributions-to-psychotherapy
#8
REVIEW
S Frisch
The life and works of neurologist and psychiatrist Kurt Goldstein (1878-1965) were almost forgotten for decades but have aroused increasing interest in recent years. Studies on Goldstein generally focus on his groundbreaking contributions to a holistic neurology, neuropsychology and neurorehabilitation; however, his contributions to the development of psychotherapy have received less attention. The present article reviews Goldstein's substantial input to the development of psychotherapy, and especially of humanistic psychotherapies...
June 18, 2018: Der Nervenarzt
https://www.readbyqxmd.com/read/29915810/recommendations-from-transgender-healthcare-consumers-in-rural-areas
#9
Douglas Knutson, Meredith A Martyr, Travis A Mitchell, Tori Arthur, Julie M Koch
Purpose: Scholars indicate that rates of mental and physical health issues (e.g., substance use, anxiety, depression) may be much higher among transgender individuals relative to the general population. This disparity may be even greater for transgender individuals in rural areas. Clinical researchers suggest using affirmative therapeutic approaches and interventions to address the health concerns of transgender individuals, specifically to connect individuals with the transgender community. However, little is known about the content of information that is shared in transgender communities in rural areas...
2018: Transgender Health
https://www.readbyqxmd.com/read/29915587/glucocorticoid-induced-leucine-zipper-fine-tuning-of-dendritic-cells-function
#10
REVIEW
Mathias Vétillard, Géraldine Schlecht-Louf
Dendritic cells (DCs) are key antigen-presenting cells that control the induction of both tolerance and immunity. Understanding the molecular mechanisms regulating DCs commitment toward a regulatory- or effector-inducing profile is critical for better designing prophylactic and therapeutic approaches. Initially identified in dexamethasone-treated thymocytes, the glucocorticoid-induced leucine zipper (GILZ) protein has emerged as a critical factor mediating most, but not all, glucocorticoids effects in both non-immune and immune cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29915509/improvising-livestock-service-in-hilly-regions-through-indigenous-wisdom-towards-control-of-tick-infestation-institutional-relationships
#11
Khumaji Badaji Kataviya, Bharat Parmar, Ramesh Patel, Pranab Jyoti Das, Vivek Kumar, Amit Mahajan, Ravinder Singh, Devesh Thakur, Amol Kinhekar, R K Ravikumar, Vipin Kumar
Aim: This study was conducted to demonstrate the acaricide efficacy of novel indigenous veterinary medication shared by an outstanding knowledge holder against naturally infested cattle and efforts in mainstreaming such wisdom. Materials and Methods: An indigenous herbal medication in control of tick infestation was documented, and experimentation was held against naturally affected cattle. Eighteen clinically infested cattle population comprising 16 crossbred and 2 non-descript cattle were purposively selected...
May 2018: Veterinary World
https://www.readbyqxmd.com/read/29915508/cryptosporidiosis-a-zoonotic-disease-concern
#12
REVIEW
Natapol Pumipuntu, Supawadee Piratae
Cryptosporidiosis is considered to be a crucial zoonotic disease caused by worldwide distributing parasitic protozoa called Cryptosporidium spp. Cryptosporidiosis becomes a major public health and veterinary concern by affecting in human and various host range species of animals. Essentially, its importance of infection is increasing because of the high incidence in young children, immunocompromised persons, or immunodeficiency syndrome patients, especially in HIV/AIDS, and it is also one of the most causes of mortality in those patients who infected with Cryptosporidium spp...
May 2018: Veterinary World
https://www.readbyqxmd.com/read/29915506/evaluation-of-hepatocyte-derived-microrna-122-for-diagnosis-of-acute-and-chronic-hepatitis-of-dogs
#13
S R Eman, A A Kubesy, T A Baraka, F A Torad, I S Shaymaa, Faten F Mohammed
Aim: This study was performed to evaluate the diagnostic value of hepatocyte-derived microRNA (miRNA)-122 in acute and chronic hepatitis of dogs. Materials and Methods: A total of 26 dogs presented at Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Cairo University, 16 dogs out of 26 showing clinical signs of hepatic insufficiency were subjected to clinical, ultrasonographic, hematobiochemical and ultrasound-guided fine-needle biopsy for cytological and histopathological investigations...
May 2018: Veterinary World
https://www.readbyqxmd.com/read/29915500/evaluation-of-wet-cupping-therapy-on-the-arterial-and-venous-blood-parameters-in-healthy-arabian-horses
#14
Turke Shawaf, Wael El-Deeb, Jamal Hussen, Mahmoud Hendi, Shahab Al-Bulushi
Aim: Recently, the complementary therapies such as cupping and acupuncture are being used in veterinary medicine. This research was carried out to determine the effects of wet cupping therapy (Hijama) on the hematological and the biochemical parameters in the healthy Arabian horses for the first time. Materials and Methods: In this study, seven clinically healthy Arabian horses were randomly selected. Four points on the animal body were selected to perform the cupping therapy...
May 2018: Veterinary World
https://www.readbyqxmd.com/read/29915499/assessment-of-the-peste-des-petits-ruminants-world-epizootic-situation-and-estimate-its-spreading-to-russia
#15
Fayssal Bouchemla, Valerey Alexandrovich Agoltsov, Olga Mikhailovna Popova, Larisa Pavlovna Padilo
Aim: This study focuses on the spatial dynamic associated with the spreading of the peste des petits ruminants (PPR) disease for the past decade (from the year 2007 to 2017), assesses the resulting situation in the world, and has an emphasis on Russian advantages been a PPR host. Materials and Methods: Outbreaks were confirmed and reported officially by the World Organization for Animal Health (enzyme-linked immunosorbent assay and polymerase chain reaction were used)...
May 2018: Veterinary World
https://www.readbyqxmd.com/read/29915112/characterisation-of-capc-a-novel-autotransporter-and-virulence-factor-of-campylobacter-jejuni
#16
Jai W Mehat, Simon F Park, Arnoud H M van Vliet, Roberto M La Ragione
Campylobacter jejuni is recognized as an important causative agent of bacterial gastroenteritis in the developed world. Despite the identification of several factors contributing to infection, characterization of the virulence strategies employed by C. jejuni remains a significant challenge. Bacterial autotransporter proteins are a major class of secretory proteins in Gram-negative bacteria and notably many autotransporter proteins contribute to bacterial virulence. The aim of this study was to characterise the C...
June 18, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29915111/microevolution-of-aquatic-streptococcus-agalactiae-st-261-from-australia-indicates-dissemination-via-imported-tilapia-and-ongoing-adaptation-to-marine-hosts-or-environment
#17
Minami Kawasaki, Jerome Delamare-Deboutteville, Rachel O Bowater, Mark J Walker, Scott Beatson, Nouri L Ben Zakour, Andrew C Barnes
Streptococcus agalactiae (GBS) causes disease in a wide range of animals. The serotype Ib lineage is highly adapted to aquatic hosts, exhibiting substantial genome reduction compared with terrestrial conspecifics. Here we sequence genomes from 40 GBS isolates including 25 from wild fish and captive stingrays in Australia, six local veterinary or human clinical isolates, and nine isolates from farmed tilapia in Honduras and compare with 42 genomes from public databases. Phylogenetic analysis based on non-recombinant core genome SNPs indicated that aquatic serotype Ib isolates from Queensland were distantly related to local veterinary and human clinical isolates...
June 18, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29914805/physiotherapy-education-is-a-good-financial-investment-up-to-a-certain-level-of-student-debt-an-inter-professional-economic-analysis
#18
Richard K Shields, Shauna Dudley-Javoroski
QUESTIONS: What is the economic value of a physiotherapy career relative to other healthcare professions? Is the graduate debt reported for physiotherapy manageable according to recommended salary-weighted debt service ratio benchmarks? DESIGN: Net present value (NPV) is an economic modelling approach that compares costs and benefits of an investment such as healthcare education. An economic analysis using the NPV approach was conducted and reported in US dollars for the Doctor of Physical Therapy degree...
June 15, 2018: Journal of Physiotherapy
https://www.readbyqxmd.com/read/29914751/icu-telemedicine-reduces-interhospital-icu-transfers-in-the-veterans-health-administration
#19
Spyridon Fortis, Mary V Sarrazin, Brice F Beck, Ralph J Panos, Heather S Reisinger
BACKGROUND: The effect of ICU telemedicine on transfers is not well studied. This study tests the hypothesis that ICU telemedicine decreases ICU patient interhospital transfers. METHODS: Data were retrieved for patients admitted to 306 Veterans Affairs ICUs in 117 acute care facilities between 2011 and 2015. Telemedicine was provided to 52 ICUs in 23 acute care facilities by two support centers located in Minneapolis and Cincinnati. We compared interhospital transfer rates in ICU telemedicine-affiliated hospitals with transfer rates of facilities with no telemedicine program...
June 5, 2018: Chest
https://www.readbyqxmd.com/read/29914682/inflammasomes-in-livestock-and-wildlife-insights-into-the-intersection-of-pathogens-and-natural-host-species
#20
Catherine E Vrentas, Robert G Schaut, Paola M Boggiatto, Steven C Olsen, Fayyaz S Sutterwala, Mahtab Moayeri
The inflammasome serves as a mechanism by which the body senses damage or danger. These multiprotein complexes form in the cytosol of myeloid, epithelial and potentially other cell types to drive caspase-1 cleavage and the secretion of the pro-inflammatory cytokines IL-1β and IL-18. Different types of inflammasomes, centered on (and named after) their cytosolic NLRs, respond to signals from bacteria, fungi, and viruses, as well as "sterile inflammatory" triggers. Despite the large body of research accumulated on rodent and human inflammasomes over the past 15 years, only recently have studies expanded to consider the role of inflammasomes in veterinary and wildlife species...
July 2018: Veterinary Immunology and Immunopathology
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