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https://www.readbyqxmd.com/read/29352704/treatment-of-adult-chronic-indeterminate-chagas-disease-with-benznidazole-and-three-e1224-dosing-regimens-a-proof-of-concept-randomised-placebo-controlled-trial
#1
Faustino Torrico, Joaquim Gascon, Lourdes Ortiz, Cristina Alonso-Vega, María-Jesús Pinazo, Alejandro Schijman, Igor C Almeida, Fabiana Alves, Nathalie Strub-Wourgaft, Isabela Ribeiro
BACKGROUND: Chagas disease is a major neglected vector-borne disease. In this study, we investigated the safety and efficacy of three oral E1224 (a water-soluble ravuconazole prodrug) regimens and benznidazole versus placebo in adult chronic indeterminate Chagas disease. METHOD: In this proof-of-concept, double-blind, randomised phase 2 clinical trial, we recruited adults (18-50 years) with confirmed diagnosis of Trypanosoma cruzi infection from two outpatient units in Bolivia...
January 15, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29350097/paternal-perinatal-depression-assessed-by-the-edinburgh-postnatal-depression-scale-and-the-gotland-male-depression-scale-prevalence-and-possible-risk-factors
#2
Magdalena Carlberg, Maigun Edhborg, Lene Lindberg
Several studies have used the Edinburgh Postnatal Depression Scale (EPDS), developed to screen new mothers, also for new fathers. This study aimed to further contribute to this knowledge by comparing assessment of possible depression in fathers and associated demographic factors by the EPDS and the Gotland Male Depression Scale (GMDS), developed for "male" depression screening. The study compared EPDS score ≥10 and ≥12, corresponding to minor and major depression, respectively, in relation to GMDS score ≥13...
January 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29349269/fertility-behaviors-in-south-korea-and-their-association-with-ultrasound-prenatal-sex-screening
#3
Jinkook Lee, James P Smith
Imbalances in the sex ratio at birth in Southeast and East Asia increased especially after the mid-1980s. We study how ultrasonic technology affected sex ratios at birth in South Korea, a country with a strong son preference. Between 1985 and 1995 fetal screenings and abortion services were widely available, though not available in the years before, and prohibited in the years after. Using the 1985, 1995, and 2005 Census microdata, we examine changes in sex ratios of newborns by birth year. We then study periodic effects on the fertility stopping rule, using the 2006 Korean Longitudinal Study of Aging, which provides birth years for all children...
April 2018: SSM—Population Health
https://www.readbyqxmd.com/read/29326327/national-roll-out-of-latent-tuberculosis-testing-and-treatment-for-new-migrants-in-england-a-retrospective-evaluation-in-a-high-incidence-area
#4
Miranda G Loutet, Matthew Burman, Nivenka Jayasekera, Duncan Trathen, Susan Dart, Heinke Kunst, Dominik Zenner
Latent tuberculosis infection (LTBI) screening is an important intervention for tuberculosis (TB) elimination in low-incidence countries and is, therefore, a key component of England's TB control strategy. This study describes outcomes from a LTBI screening programme in a high-incidence area to inform national LTBI screening in England and other low-incidence countries.We conducted a retrospective cohort study of LTBI screening among eligible migrants (from high-incidence countries and entered the UK within the last 5 years), who were identified at primary-care clinics in Newham, London between August 2014 and August 2015...
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29273943/thyroid-disease-in-children-and-adolescents-with-pten-hamartoma-tumor-syndrome-phts
#5
Michaela Plamper, Felix Schreiner, Bettina Gohlke, Janina Kionke, Eckard Korsch, James Kirkpatrick, Mark Born, Stefan Aretz, Joachim Woelfle
Patients with PTEN hamartoma tumor syndrome (PHTS) are at increased risk of developing benign and malignant tumors, including thyroid carcinoma. Benign thyroid lesions and single cases of thyroid carcinoma have been reported in children with PHTS. We conducted a retrospective, single-centered study including children and adolescents with a molecularly proven diagnosis of PTEN. Our cohort consists of 16 patients, with a mean age at diagnosis PHTS of 5.7 years. Twelve of 16 cases exhibited thyroid abnormalities (75%)...
December 22, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29273042/coronavirus-and-paramyxovirus-in-bats-from-northwest-italy
#6
Francesca Rizzo, Kathryn M Edenborough, Roberto Toffoli, Paola Culasso, Simona Zoppi, Alessandro Dondo, Serena Robetto, Sergio Rosati, Angelika Lander, Andreas Kurth, Riccardo Orusa, Luigi Bertolotti, Maria Lucia Mandola
BACKGROUND: Bat-borne virus surveillance is necessary for determining inter-species transmission risks and is important due to the wide-range of bat species which may harbour potential pathogens. This study aimed to monitor coronaviruses (CoVs) and paramyxoviruses (PMVs) in bats roosting in northwest Italian regions. Our investigation was focused on CoVs and PMVs due to their proven ability to switch host and their zoonotic potential. Here we provide the phylogenetic characterization of the highly conserved polymerase gene fragments...
December 22, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29261661/individual-co-variation-between-viral-rna-load-and-gene-expression-reveals-novel-host-factors-during-early-dengue-virus-infection-of-the-aedes-aegypti-midgut
#7
Vincent Raquin, Sarah Hélène Merkling, Valérie Gausson, Isabelle Moltini-Conclois, Lionel Frangeul, Hugo Varet, Marie-Agnès Dillies, Maria-Carla Saleh, Louis Lambrechts
Dengue virus (DENV) causes more human infections than any other mosquito-borne virus. The current lack of antiviral strategies has prompted genome-wide screens for host genes that are required for DENV infectivity. Earlier transcriptomic studies that identified DENV host factors in the primary vector Aedes aegypti used inbred laboratory colonies and/or pools of mosquitoes that erase individual variation. Here, we performed transcriptome sequencing on individual midguts in a field-derived Ae. aegypti population to identify new candidate host factors modulating DENV replication...
December 19, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29259931/bone-marrow-necrosis-and-fat-embolism-syndrome-a-dreadful-complication-of-hemoglobin-sickle-cell-disease
#8
Eduardo Pelegrineti Targueta, André Carramenha de Góes Hirano, Fernando Peixoto Ferraz de Campos, João Augusto Dos Santos Martines, Silvana Maria Lovisolo, Aloisio Felipe-Silva
Sickle cell disease encompasses a wide range of genotypic presentation with particular clinical features. The entity affects millions of people, particularly those whose ancestors came from sub-Saharan Africa and other countries in the Western Hemisphere, Saudi Arabia, and India. Currently, the high frequency of S and C genes reflects natural selection through the protection of heterozygotes against severe malaria, the high frequency of consanguineous marriages, improvement of some public health policies and the nutritional standards in the poorer countries where newborns are now living long enough to present for diagnosis and management...
October 2017: Autopsy & Case Reports
https://www.readbyqxmd.com/read/29258957/decreased-macrophage-phagocytic-function-due-to-xenobiotic-exposures-in-vitro-difference-in-sensitivity-between-various-macrophage-models
#9
Hanne Friis Berntsen, Anette Kocbach Bølling, Cesilie Granum Bjørklund, Karin Zimmer, Erik Ropstad, Shanbeh Zienolddiny, Rune Becher, Jørn A Holme, Hubert Dirven, Unni Cecilie Nygaard, Johanna Bodin
Both autoimmune disease prevalence and exposure to immunotoxic chemicals have increased the last decades. As a first screening of immunotoxic chemicals possibly affecting development of autoimmunity through attenuated macrophage function, we demonstrate a promising model measuring macrophage function in isolated peritoneal macrophages (PCM) from Wistar rats and C57Bl/6 mice. Immunotoxic effects of bisphenol A (BPA) and a selection of perfluoroalkyl acids (PFAAs) were analysed in vitro assessing phagocytic function of macrophages from different sources...
December 16, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29209920/a-pilot-program-integrating-hepatitis-b-virus-hbv-screening-into-an-outpatient-endoscopy-unit-improves-hbv-screening-among-an-ethnically-diverse-safety-net-hospital
#10
Brendan Campbell, Aristeo Lopez, Benny Liu, Taft Bhuket, Robert J Wong
BACKGROUND: Safety-net hospitals are enriched in ethnic minorities and provide opportunities for high-impact hepatitis B virus (HBV) screening. AIM: We aim to evaluate the impact of a pilot program integrating HBV screening into outpatient endoscopy among urban safety-net populations. METHODS: From July 2015 to May 2017, consecutive adults undergoing outpatient endoscopy were prospectively assessed for HBV screening eligibility using US Preventative Services Task Force guidelines...
December 5, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29202151/screening-for-tuberculosis-updated-recommendations
#11
Doug Campos-Outcalt
Tuberculosis (TB) remains a significant public health problem worldwide with an estimated 10.4 million new cases and 1.7 million deaths having occurred in 2016. In that same year, there were 9287 new cases in the United States--the lowest number of TB cases on record. TB appears in one of 2 forms: active disease, which causes symptoms, morbidity, and mortality and is a source of transmission to others; and latent TB infection (LTBI), which is asymptomatic and noninfectious but can progress to active disease...
December 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/29192716/the-cardiotomy-reservoir-a-preliminary-evaluation-of-a-new-cell-source-for-cardiovascular-tissue-engineering
#12
Sophie von Nathusius, Fabian König, Ralf Sodian, Frank Born, Christian Hagl, Nikolaus Thierfelder
OBJECTIVES: Cell sources for cardiovascular tissue engineering (TE) are scant. However, the need for an ideal TE cardiovascular implant persists. We investigated the cardiotomy reservoir (CR) as a potential cell source that is more accessible and less ethically problematic. METHODS: CR (n = 10) were removed from the bypass system after surgery. Isolation was performed using different isolation methods: blood samples were taken from the cardiopulmonary bypass and centrifuged at low density...
November 21, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29188776/metal-complexes-of-isonicotinylhydrazide-and-their-antitubercular-activity
#13
Mohsin Ali, Mansoor Ahmed, Saleem Hafiz, Mustafa Kamal, Majid Mumtaz, Muhammad Hanif, Khalid Mohammed Khan
The development and spreading of Multi Drug Resistant TB strains is hampering endeavours for the control and administration of tuberculosis (TB). The expansion episodes of multi-medication safe strains of Mycobacterium tuberculosis against first and second line antituberculosis drugs on one side and the unfavourable effects of these drugs on the other side has led the enthusiasm of researcher towards the synthesis of metal complexes of various medication. This approach is born with the expectation of finding new antituberculous operators without or least reactions as well as being active against the resistant strains of Mycobacterium tuberculosis...
November 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29176498/zika-clinical-updates-implications-for-pediatrics
#14
Kristina Adachi, Karin Nielsen-Saines
PURPOSE OF REVIEW: Zika virus (ZIKV), a mosquito-borne flavivirus, has gained recognition over the past few years as an important new cause of congenital infection. As a result, it is critical that pediatricians understand its epidemiology, clinical presentation, clinical sequelae, and management. RECENT FINDINGS: The recent ZIKV epidemiology, clinical presentation of acute infection in children and complications, perinatal infection, and congenital infection will be summarized in this ZIKV review...
November 25, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29172245/the-swedish-pregnancy-register-for-quality-of-care-improvement-and-research
#15
Olof Stephansson, Kerstin Petersson, Camilla Björk, Peter Conner, Anna-Karin Wikström
INTRODUCTION: The objective was to present the Swedish Pregnancy Register and to explore regional differences in maternal characteristics, antenatal care, first trimester combined screening and delivery outcomes in Sweden. MATERIAL AND METHODS: The Pregnancy Register (www.graviditetsregistret.se) collects data on pregnancy and childbirth, starting at the first visit to antenatal care and ending at the follow-up visit to the antenatal care, which usually occurs at around 8-16 weeks postpartum...
November 24, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29152920/using-state-birth-defects-registries-to-evaluate-regional-critical-congenital-heart-disease-newborn-screening
#16
Amy Peterson Case, Stephanie D Miller, Monica R McClain
BACKGROUND: Most states have now passed legislation mandating pulse oximetry for all newborns, or have promulgated regulations or guidelines to encourage use of routine pulse oximetry. State-based birth defects registries may be well positioned to track and evaluate critical congenital heart disease (CCHD) screening coverage and outcomes. This purpose of this study was to determine: (1) the proportion of cases detected by screening, (2) health services use by children with CCHDs during the first year of life, and (3) mortality outcomes...
November 1, 2017: Birth defects research
https://www.readbyqxmd.com/read/29150458/diagnostic-accuracy-of-neonatal-assessment-for-gestational-age-determination-a-systematic-review
#17
REVIEW
Anne Cc Lee, Pratik Panchal, Lian Folger, Hilary Whelan, Rachel Whelan, Bernard Rosner, Hannah Blencowe, Joy E Lawn
CONTEXT: An estimated 15 million neonates are born preterm annually. However, in low- and middle-income countries, the dating of pregnancy is frequently unreliable or unknown. OBJECTIVE: To conduct a systematic literature review and meta-analysis to determine the diagnostic accuracy of neonatal assessments to estimate gestational age (GA). DATA SOURCES: PubMed, Embase, Cochrane, Web of Science, POPLINE, and World Health Organization library databases...
December 2017: Pediatrics
https://www.readbyqxmd.com/read/29147652/identification-of-potent-chloride-intracellular-channel-protein-1-inhibitors-from-traditional-chinese-medicine-through-structure-based-virtual-screening-and-molecular-dynamics-analysis
#18
Wei Wang, Minghui Wan, Dongjiang Liao, Guilin Peng, Xin Xu, Weiqiang Yin, Guixin Guo, Funeng Jiang, Weide Zhong, Jianxing He
Chloride intracellular channel 1 (CLIC1) is involved in the development of most aggressive human tumors, including gastric, colon, lung, liver, and glioblastoma cancers. It has become an attractive new therapeutic target for several types of cancer. In this work, we aim to identify natural products as potent CLIC1 inhibitors from Traditional Chinese Medicine (TCM) database using structure-based virtual screening and molecular dynamics (MD) simulation. First, structure-based docking was employed to screen the refined TCM database and the top 500 TCM compounds were obtained and reranked by X-Score...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29142787/sleep-apnea-symptoms-and-cardiovascular-disease-risks-among-haitian-medical-students
#19
Diana M Rosenthal, Donaldson F Conserve, Dodley Severe, Michaele A Gedeon, Ferdinand Zizi, Georges Casimir, Samy I McFarlane, Girardin Jean Louis
Sleep apnea is a prevalent sleep disorder that disproportionately affects blacks and has been previously studied among Caribbean-born blacks in Brooklyn, New York, but there has been negligible research in the Caribbean, specifically Haiti, and developing countries on this pressing health issue. A total of 373 medical students (mean age=20.6 years ± 2.3 years) from a medical school in Haiti participated in this study. Participants were administered a questionnaire assessing their sleep health and cardiovascular outcomes...
April 2017: Journal of Sleep Disorders & Therapy
https://www.readbyqxmd.com/read/29141726/status-of-insecticide-resistance-in-papua-new-guinea-an-update-from-nation-wide-monitoring-of-anopheles-mosquitoes
#20
Gussy Koimbu, Cyrille Czeher, Michelle Katusele, Muker Sakur, Lemen Kilepak, Anthony Tandrapah, Manuel W Hetzel, Justin Pulford, Leanne Robinson, Stephan Karl
Insecticide resistance (IR) monitoring is an important component of vector-borne disease control. The last assessment of IR in Papua New Guinea (PNG) was conducted in 2010. Since then, vector populations have been exposed to higher levels of pyrethroids with the continued nation-wide distribution of insecticide-treated nets. Here, we provide an update on phenotypic IR in four highly malaria-endemic areas of PNG. IR against deltamethrin, lambda-cyhalothrin, and dichlorodiphenyltrichloroethane was assessed using World Health Organization bioassays...
November 6, 2017: American Journal of Tropical Medicine and Hygiene
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