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Gastric cancer and endoscopy

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https://www.readbyqxmd.com/read/28639135/histological-verification-of-the-usefulness-of-magnifying-endoscopy-with-narrow-band-imaging-for-horizontal-margin-diagnosis-of-differentiated-type-early-gastric-cancers
#1
Makomo Makazu, Kingo Hirasawa, Chiko Sato, Ryosuke Ikeda, Takehide Fukuchi, Yasuaki Ishii, Ryosuke Kobayashi, Hiroaki Kaneko, Masataka Taguri, Yoko Tateishi, Yoshiaki Inayama, Shin Maeda
BACKGROUND: Although magnifying endoscopy with narrow-band imaging (ME-NBI) can help identify the horizontal margin (HM) of early gastric cancer (EGC), little is known about the factors that can clarify the HM by using ME-NBI. We aimed to characterize the pathological features of lesions in which the HM was identified using ME-NBI. METHODS: The HMs of 639 differentiated-type EGCs treated with endoscopic submucosal dissection or surgery were analyzed using conventional endoscopy and ME-NBI...
June 21, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28631728/acg-and-cag-clinical-guideline-management-of-dyspepsia
#2
Paul M Moayyedi, Brian E Lacy, Christopher N Andrews, Robert A Enns, Colin W Howden, Nimish Vakil
We have updated both the American College of Gastroenterology (ACG) and the Canadian Association of Gastroenterology (CAG) guidelines on dyspepsia in a joint ACG/CAG dyspepsia guideline. We suggest that patients ≥60 years of age presenting with dyspepsia are investigated with upper gastrointestinal endoscopy to exclude organic pathology. This is a conditional recommendation and patients at higher risk of malignancy (such as spending their childhood in a high risk gastric cancer country or having a positive family history) could be offered an endoscopy at a younger age...
June 20, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28619681/gastric-carcinoma-after-sleeve-gastrectomy-for-obesity
#3
Miljana Vladimirov, Uwe Hesse, Hubert J Stein
Obesity is associated with an increased risk of cancer development in the upper gastrointestinal tract. We present the case of a female patient with gastric carcinoma after sleeve gastrectomy. Before bariatric surgery, one rationale for performing routine endoscopy is to detect clinically relevant conditions with the potential to change the surgical procedure. After bariatric surgery in symptomatic patients and in patients with unspecific symptoms, early upper endoscopy should be performed to detect potential carcinomas of the upper gastrointestinal tract...
April 25, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28600361/coding-of-barrett-s-oesophagus-with-high-grade-dysplasia-in-national-administrative-databases-a-population-based-cohort-study
#4
Georgina Chadwick, Mira Varagunam, Christian Brand, Stuart A Riley, Nick Maynard, Tom Crosby, Julie Michalowski, David A Cromwell
OBJECTIVES: The International Classification of Diseases 10th Revision (ICD-10) system used in the English hospital administrative database (Hospital Episode Statistics (HES)) does not contain a specific code for oesophageal high-grade dysplasia (HGD). The aim of this paper was to examine how patients with HGD were coded in HES and whether it was done consistently. SETTING: National population-based cohort study of patients with newly diagnosed with HGD in England...
June 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28599492/histological-evaluations-of-primary-lesions-are-independently-associated-with-prognosis-in-patients-with-gastric-cancer-who-receive-neoadjuvant-chemotherapy
#5
Tomomitsu Tahara, Tomoyuki Shibata, Masaaki Okubo, Dai Yoshida, Tomohiko Kawamura, Noriyuki Horiguchi, Takamitsu Ishizuka, Mitsuo Nagasaka, Yoshihito Nakagawa, Naoki Ohmiya
Neoadjuvant chemotherapy may improve outcomes for patients with locally advanced gastric cancer (GC). To explore useful predictive factors for the response of advanced GC to neoadjuvant chemotherapy, tumor responses were assessed using computed tomography (CT) with histological based criteria. A total of 78 patients with advanced GC undergoing neoadjuvant chemotherapy were included. CT-based response assessment was performed following 2 courses of treatment. Histological evaluation of resected specimens was also performed according to the Japanese classification of gastric carcinoma...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28596787/clinical-usefulness-of-the-vs-classification-system-using-magnifying-endoscopy-with-blue-laser-imaging-for-early-gastric-cancer
#6
Yoshikazu Yoshifuku, Yoji Sanomura, Shiro Oka, Kazutaka Kuroki, Mio Kurihara, Takeshi Mizumoto, Yuji Urabe, Toru Hiyama, Shinji Tanaka, Kazuaki Chayama
BACKGROUND: Blue laser imaging (BLI) enables the acquisition of more information from tumors' surfaces compared with white light imaging. Few reports confirm the validity of magnifying endoscopy (ME) with BLI (ME-BLI) for early gastric cancer (EGC). We aimed to assess the detailed endoscopic findings from EGCs using ME-BLI. METHODS: We enrolled 386 consecutive patients with 417 EGCs that were diagnosed using ME-BLI and resected by endoscopic submucosal dissection...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28596683/polymorphisms-of-microrna-target-genes-il12b-insr-ccnd1-and-il10-in-gastric-cancer
#7
Vytenis Petkevicius, Violeta Salteniene, Simonas Juzenas, Thomas Wex, Alexander Link, Marcis Leja, Ruta Steponaitiene, Jurgita Skieceviciene, Limas Kupcinskas, Laimas Jonaitis, Gediminas Kiudelis, Peter Malfertheiner, Juozas Kupcinskas
AIM: To evaluate associations between miRNA target genes IL12B, INSR, CCND1 and IL10 polymorphisms and gastric cancer (GC) in European population. METHODS: Gene polymorphisms were analyzed in 508 controls and 474 GC patients from 3 tertiary centers in Germany, Lithuania and Latvia. Controls were patients from the out-patient departments, who were referred for upper endoscopy because of dyspeptic symptoms and had no history of previous malignancy. Gastric cancer (GC) patients had histopathological verification of gastric adenocarcinoma...
May 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28596594/magnifying-narrow-band-imaging-of-gastric-mucosal-morphology-predicts-the-h-pylori-related-epigenetic-field-defect
#8
Tomomitsu Tahara, Jumpei Yamazaki, Sayumi Tahara, Masaaki Okubo, Tomohiko Kawamura, Noriyuki Horiguchi, Takamitsu Ishizuka, Mitsuo Nagasaka, Yoshihito Nakagawa, Tomoyuki Shibata, Makoto Kuroda, Naoki Ohmiya
DNA methylation is associated with "field defect" in the gastric mucosa. To characterize "field defect" morphologically, we examined DNA methylation of non-neoplastic gastric mucosa in relation to their morphology seen by narrow-band imaging (NBI) with magnifying endoscopy. Magnifying NBI of non-neoplastic gastric body was classified as follows: normal-small and round pits with uniform subepithelial capillary networks; type 1-a little enlarged round pits with indistinct subepithelial capillary networks; type 2-remarkably enlarged pits with irregular vessels; and type 3-clearly demarcated oval or tubulovillous pits with bulky coiled or wavy vessels...
June 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28591047/inverted-gastric-adenocarcinoma-of-fundic-gland-mucosa-type-colliding-with-well-differentiated-adenocarcinoma-a-case-report
#9
Keitaro Takahashi, Mikihiro Fujiya, Shin Ichihara, Kentaro Moriichi, Toshikatsu Okumura
RATIONALE: Gastric adenocarcinoma of fundic gland mucosa type (GA-FGM) is a rare tumor composed of atypical cells with differentiation toward the fundic gland as well as the foveolar epithelium. Including our case, only 9 cases of GA-FGMs were reported from 2010 to 2016. CONCERNS OF THE PATIENT: An 87-year-old man was referred to our institution for endoscopic resection of a gastric lesion. The tumor was classified as type 0-I + IIa according to the Paris classification...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28590294/colonic-parasitic-infection-mimicking-peritoneal-seeding-on-18f-fdg-pet-ct
#10
Beong Woo Kim, Hae Won Kim, Kyoung Sook Won, Yu-Na Kang, Byung-Wook Choi
A 77-year-old man with anorexia and weight loss for 6 months received a diagnosis of gastric cancer by endoscopy and referred for F-FDG PET/CT for initial staging. F-FDG PET/CT showed multiple foci of increased FDG uptake with diffuse wall thickening and multiple diverticula. The differential diagnoses were peritoneal seeding and multiple diverticulitis. The patient underwent curative total gastrectomy, and the lesion was diagnosed as poorly differentiated adenocarcinoma by histological examination. He underwent anterior resection of the sigmoid colon for exploration...
June 5, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28571523/association-of-heterogenicity-of-helicobacter-pylori-cag-pathogenicity-island-with-peptic-ulcer-diseases-and-gastric-cancer
#11
J Khatoon, K N Prasad, R Prakash Rai, U C Ghoshal, N Krishnani
OBJECTIVE: To investigate the frequency and integrity of certain cag pathogenicity island genes (cagPAI) in Helicobacter pylori strains and their association with peptic ulcer disease (PUD) and gastric cancer. MATERIAL AND METHODS: We enrolled 240 adult patients [120 with functional dyspepsia (FD), 50 with PUD and 70 with gastric cancer] undergoing upper gastrointestinal endoscopy. H. pylori infection was diagnosed when either culture or any two of the three tests (rapid urease test, histopathology and specific ureA PCR) were positive...
June 2, 2017: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/28559820/nivolumab-therapy-for-synchronous-alk-positive-lung-cancer-and-gastric-cancer
#12
Masahiro Yamasaki, Naomi Saito, Yu Hada, Sayaka Miyamoto, Hideharu Okanobu, Naoya Ikeda, Wakako Daido, Sayaka Ishiyama, Naoko Deguchi, Masaya Taniwaki, Nobuyuki Ohashi
Nivolumab is an immune checkpoint inhibitor with demonstrated efficacy against several malignant tumors. Alterations in driver oncogenes such as EGFR and ALK are a poor prognostic factor in nivolumab therapy for non-small cell lung cancer (NSCLC), whereas a smoking history is a well-known, favorable prognostic factor. However, an efficacy of nivolumab therapy for multiple primary malignant tumors (MPMTs) has not been reported, and its efficacy for driver oncogene-positive NSCLC in smokers is unclear. Herein, we report the case of a patient with a history of heavy smoking who developed synchronous ALK-positive NSCLC and gastric cancer that responded to nivolumab therapy...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28552126/hue-texture-embedded-region-based-model-for-magnifying-endoscopy-with-narrow-band-imaging-image-segmentation-based-on-visual-features
#13
Xiaoqi Liu, Chengliang Wang, Jianying Bai, Guobin Liao, Yanjun Zhao
BACKGROUND AND OBJECTIVE: Magnification endoscopy with narrow-band imaging (ME-NBI) has become a feasible tool for detecting diseases within the human gastrointestinal tract, and is more applied by physicians to search for pathological abnormalities with gastric cancer such as precancerous lesions, early gastric cancer and advanced cancer. In order to improve the reliability of diseases detection, there is a need for applying or proposing computer-assisted methodologies to efficiently analyze and process ME-NBI images...
July 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28550494/cost-effectiveness-of-combined-serum-anti-helicobacter-pylori-igg-antibody-and-serum-pepsinogen-concentrations-for-screening-for-gastric-cancer-risk-in-japan
#14
Shota Saito, Motoi Azumi, Yusuke Muneoka, Katsuhiko Nishino, Takashi Ishikawa, Yuichi Sato, Shuji Terai, Kouhei Akazawa
BACKGROUND: A combination of assays for the presence of serum anti-Helicobacter pylori IgG antibody (HPA) and serum pepsinogen (PG) concentrations can be used to screen for gastric cancer risk. In Japan, this "ABC method" is considered an effective means of stratifying gastric cancer risk. This study aimed to ascertain its cost-effectiveness for assessing gastric cancer risk. METHODS: A Markov model was constructed to compare the cost-effectiveness of two strategies for gastric cancer-risk screening over a 30-year period: the ABC method, which uses a combination of assessing the presence of HPA and measuring serum PG concentrations and scheduling endoscopies accordingly, and annual endoscopic screening...
May 26, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/28532700/gastric-cancer-as-preventable-disease
#15
Massimo Rugge, Robert M Genta, Francesco Di Mario, Emad M El-Omar, Hashem B El-Serag, Matteo Fassan, Richard H Hunt, Ernst J Kuipers, Peter Malfertheiner, Kentaro Sugano, David Y Graham
Gastric cancer (GC), one of the five most common causes of cancer death, is associated with a 5-year overall survival rate less than 30%. A minority of cancers occurs as part of syndromic diseases; more than 90% of adenocarcinomas are considered as the ultimate consequence of a longstanding mucosal inflammation. H. pylori infection is the leading etiology of non-self-limiting gastritis, which may result in atrophy of the gastric mucosa and impaired acid secretion. Gastric atrophy establishes a field of cancerization prone to further molecular and phenotypic changes, possibly resulting in cancer growth...
May 19, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28516058/comparison-of-amoxicillin-and-metronidazole-effect-on-three-drug-regimen-for-the-treatment-of-helicobacter-pylori-infection-in-children
#16
Karam-Ali Kasiri, Abolfazl Khoshdel, Afshin Karimi, Morteza Sedehi, Niloufar Kasiri
Helicobacter pylori is an important risk factor for chronic gastritis, peptic ulcer, and gastric cancer. Three-drug regimen is the first-line treatment for this infection, but the response rate to treatment varies in different geographical regions. This study was conducted to comparatively determine the effect of amoxicillin and metronidazole on three-drug regimen to treat H. pylori infection in 1-15-year-old children. This clinical trial was conducted on 82 patients aged 1-15 years with convenience sampling referring to the Endoscopy Unit of Hajar Hospital, Shahrekord...
April 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28514928/challenges-in-evaluation-of-screening-for-gastric-cancer-among-men-based-on-nonrandomized-design
#17
Ilkka Vohlonen, Matti Härkönen, Nea Malila, Eero Pukkala, Pentti Sipponen, Veli Koistinen, Matti Hakama
BACKGROUND: Objective was to quantify biases in screening for gastric cancer when comparing attenders to nonattenders using serum pepsinogen I (SPGI) level as primary test. METHODS: In mid 1990s, all men aged 51-65 years from two Finnish cities were invited to SPGI screening. Mortality and premature mortality in attenders were compared to nonattenders. Efficacy of screening was studied by 15 years' follow-up of standardized mortality ratio (SMR) and potential years of life lost (PYLL) due to gastric cancer...
July 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28496533/the-diagnostic-value-of-alarm-features-for-identifying-types-and-stages-of-upper-gastrointestinal-malignancies
#18
Shou-Wu Lee, Chi-Sen Chang, Hong-Jeh Yeh, Han-Chung Lien, Teng-Yu Lee, Yen-Chun Peng
BACKGROUND: Upper gastrointestinal (GI) malignancies are an uncommon cause of dyspepsia but of great concern. The aim of this study was to determine the association between alarm features and each type and stage of upper GI malignancies. METHODS: Patients who underwent endoscopy for symptoms of dyspepsia between January 2008 and December 2009 were retrospectively collected. Alarm features studied in this study were dysplasia, body weight loss and GI bleeding. Patients were classified according to the findings of endoscopy and histological reports...
April 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/28483604/selective-approach-for-patients-with-advanced-malignancy-and-gastrointestinal-obstruction
#19
Deep Pujara, Yi-Ju Chiang, Janice N Cormier, Eduardo Bruera, Brian Badgwell
BACKGROUND: The purpose of this study was to determine the frequency of tumor-related gastrointestinal obstruction and identify variables associated with functional outcome and survival in patients with advanced malignancy and gastrointestinal obstruction. STUDY DESIGN: We reviewed the medical records of 490 patients with advanced cancer who underwent surgical consultation for gastrointestinal obstruction between January 2000 and May 2014. We used chi-square and logistic regression analyses to identify variables associated with survival and eating at discharge...
May 5, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28469371/percutaneous-endoscopy-to-diagnose-malignancy-in-gastric-outlet-obstruction-of-excluded-stomach-after-gastric-bypass
#20
Waseem Ahmad, Joshua Rubin, Wilson Kwong
Gastric cancer in the excluded stomach after Roux-en-Y gastric bypass is a rare finding and most reported diagnoses are made via surgery. Endoscopic access to the excluded stomach is difficult, even with balloon-assisted enteroscopy. We present the case of a 74-year-old woman with malignant gastric outlet obstruction of the excluded stomach, 41 years after Roux-en-Y gastric bypass. Minimally invasive access to the excluded stomach was obtained by placement of a percutaneous gastrostomy tube, followed by insertion of a pediatric gastroscope through the gastrostomy tube tract...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
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