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REVIEW
Tulip A Jhaveri, Zoe Freeman Weiss, Marisa L Winkler, Alexander D Pyden, Sankha S Basu, Nicole D Pecora
The past 10 years have brought paradigm-shifting changes to clinical microbiology. This paper explores the top 10 transformative innovations across the diagnostic spectrum, including not only state of the art technologies but also preanalytic and post-analytic advances. Clinical decision support tools have reshaped testing practices, curbing unnecessary tests. Innovations like broad-range polymerase chain reaction and metagenomic sequencing, whole genome sequencing, multiplex molecular panels, rapid phenotypic susceptibility testing, and matrix-assisted laser desorption ionization time-of-flight mass spectrometry have all expanded our diagnostic armamentarium...
2024: Antimicrob Steward Healthc Epidemiol
#22
JOURNAL ARTICLE
Kaixiong Liu, Luling Wu, Gongping Chen, Dunhuan Zeng, Qiwei Zhong, Li Luo, Bin Song, Xiuhong Ying, Fayu Ni, Lifang Yu, Liyu Xu, Xin Lin, Xiaoyan Chen, Xin Zou, Jianhong Xiao, Yuekai Hu
OBJECTIVE: This study aimed to describe and compare the epidemiological, demographic, clinical, laboratory and radiological characteristics as well as the complications, treatments, and outcomes of these patients. METHODS: We retrospectively investigated clinical data of patients with C. psittaci infection (psittacosis) in eight Grade IIIA hospitals of Fujian. Metagenomic next-generation sequencing (mNGS) was used identify C. psittaci in clinical samples of all included patients...
2024: Infection and Drug Resistance
#23
JOURNAL ARTICLE
Daniel Erlacher, Daniel Schmid, Stephan Zahno, Michael Schredl
Previous research has shown that learning procedural tasks enhances REM sleep the following night. Here, we investigate whether complex motor learning affects sleep architecture. An experiment in which twenty-two subjects either learned a motor task (trampolining) or engaged in a control task (ergometer) was carried out in a balanced within-group design. After an initial laboratory adaptation night, two experimental nights were consecutive. The results indicate that learning a motor task had an effect on REM sleep parameters and, therefore, support the hypothesis that learning a procedural skill is related to an increase in REM sleep parameters...
January 31, 2024: Life
#24
JOURNAL ARTICLE
Anna Karpova, Ahmed A A Aly, Endre Levente Marosi, Sanja Mikulovic
In recent decades, various subfields within neuroscience, spanning molecular, cellular, and systemic dimensions, have significantly advanced our understanding of the elaborate molecular and cellular mechanisms that underpin learning, memory, and adaptive behaviors. There have been notable advancements in imaging techniques, particularly in reaching superficial brain structures. This progress has led to their widespread adoption in numerous laboratories. However, essential physiological and cognitive processes, including sensory integration, emotional modulation of motivated behavior, motor regulation, learning, and memory consolidation, are intricately encoded within deeper brain structures...
September 2024: Neurophotonics
#25
Liangzhe Wu, Changhong Mo, Yihan Xiong, Yanhui Chen, Meng Jin, Kunning Han, Xuejun Fu
A 54-year-old female with diabetes was admitted with fever and altered consciousness. Laboratory tests revealed venous blood glucose level of 43.79 mmol/L. Computed tomography (CT) scans of the head, chest, and abdomen showed a right-sided pneumothorax, consolidation, and atelectasis in the right lung; a large heterogeneous density lesion with fluid and gas-fluid levels in the liver; and scattered gas shadows in both kidneys, respectively. Blood and puncture fluid cultures indicated infection with Klebsiella pneumoniae ...
February 29, 2024: Heliyon
#26
JOURNAL ARTICLE
Sharmon P Osae, Russ Palmer, Ashlee Harvey, Chelsea A Keedy, Devin L Lavender, Beth Bryles Phillips, Blake R Johnson, Henry N Young, Rebecca H Stone
OBJECTIVES: Georgia Board of Pharmacy (BOP) regulations permit pharmacists to engage in collaborative drug therapy modification (CDTM) with physicians, allowing them to perform patient assessments, adjust pharmacotherapy, and order laboratory tests. Pharmacist-led CDTM can positively impact health outcomes leading to reduced healthcare expenditures. CDTM is underutilized, with <1% of Georgia pharmacists holding an active license to practice CDTM. The objective of this study was to examine CDTM licensed pharmacists' perceptions of facilitators and barriers in providing CDTM...
February 15, 2024: Journal of the American Pharmacists Association: JAPhA
#27
JOURNAL ARTICLE
Mikayla Quinton, Duane W Newton, Becky Neil, Sondra Mitchell, Heba H Mostafa
INTRODUCTION: Quality control (QC) is one component of an overarching quality management system (QMS) that aims at assuring laboratory quality and patient safety. QC data must be acceptable prior to reporting patients' results. Traditionally, QC statistics, records, and corrective actions were tracked at the Johns Hopkins Molecular Virology Laboratory using Microsoft Excel. Unity Real-Time (UnityRT), a QMS software (Bio-Rad Laboratories), which captures and analyzes QC data by instrument and control lot per assay, was implemented and its impact on the workflow was evaluated...
February 12, 2024: Journal of Clinical Virology
#28
JOURNAL ARTICLE
Qinghu Yan, Wenlong Zhao, Haili Kong, Jingyu Chi, Zhengjun Dai, Dexin Yu, Jia Cui
Global incidence rate of non-tuberculous mycobacteria (NTM) pulmonary disease has been increasing rapidly. In some countries and regions, its incidence rate is higher than that of tuberculosis. It is easily confused with tuberculosis. The topic of this study is to identify two diseases using CT radioomics. The aim in the present study was to investigate the value of CT-based radiomics to analyze consolidation features in differentiation of non-tuberculous mycobacteria (NTM) from pulmonary tuberculosis (TB)...
March 2024: Experimental and Therapeutic Medicine
#29
JOURNAL ARTICLE
Heinrich Kreutzmann, Christine Unterweger, Lukas Schwarz, Katharina Dimmel, Angelika Auer, Till Rümenapf, Andrea Ladinig
Investigating infectious agents in porcine abortion material and stillborn piglets poses challenges for practitioners and diagnostic laboratories. In this study, pooled samples of individual reference organs (thymus and heart) from a total of 1000 aborted fetuses and stillborn piglets were investigated using quantitative PCR protocols for porcine reproductive and respiratory syndrome virus 1 (PRRSV-1) and porcine circovirus type 2 (PCV2). Simultaneously, a pluck-pool containing equivalent portions of fetal thymus, heart, and lung tissue was collected, frozen at - 20°C, and re-analyzed when a certain amount of either PRRSV-1 RNA or PCV2 DNA was detected in individual reference organs...
February 13, 2024: Veterinary Journal
#30
JOURNAL ARTICLE
Mohamad Hilmi Ibrahim, Susilawati Kasim, Osumanu Haruna Ahmed, Mohd Rashid Mohd Rakib, Nur Aainaa Hasbullah, Md Tariqul Islam Shajib
Greenhouse gases can cause acid rain, which in turn degrades soil chemical properties. This research was conducted to determine the effects of simulated acid rain (SAR) on the chemical properties of Nyalau series (Typic paleudults). A 45-day laboratory leaching and incubation study (control conditions) was conducted following standard procedures include preparing simulated acid rain with specific pH levels, followed by experimental design/plan and systematically analyzing both soil and leachate for chemical changes over the 45-day period...
February 12, 2024: Scientific Reports
#31
COMMENT
Sven Vanneste
Recent experiments in rats and humans have indicated that the effects of non-invasive electrical stimulation are primarily due to transcutaneous stimulation of peripheral nerves, specifically the greater occipital nerve. This stimulation pathway activates communication gateways from the periphery to the brain, impacting memory consolidation. In this invited commentary, I delve into and offer additional insights concerning the enhancement of episodic memory through transcutaneous electrical stimulation of the greater occipital nerve, building upon the findings published by my laboratory in both Science Advances and Elife ...
2024: Neuroscience insights
#32
JOURNAL ARTICLE
Jacqueline Gri, Varun Jain
INTRODUCTION AND IMPORTANCE: Pneumocystis jirovecii (PJP) pneumonia is a serious life-threatening condition in immunocompromised individuals and is often associated with human immunodeficiency virus (HIV) + patients. We describe a case of PJP pneumonia which provided a diagnostic challenge in a patient who presented with no known risk factors leading to a delay in initiation of appropriate antibiotic therapy. CASE PRESENTATION: A 71-year-old previously healthy white/Caucasian male presented with subacute hypoxic respiratory failure due to multifocal pneumonia with diffuse bilateral ground glass opacities with consolidations despite prior treatment with antibiotics and steroids...
February 12, 2024: Journal of Medical Case Reports
#33
JOURNAL ARTICLE
Özlem Erçen Diken, Şerife Kaya, Hayriye Bektaş Aksoy, Aydanur Ekici, Aylin Çapraz, Ali Tabaru, Özlem Şengören Dikiş, Hüseyin Arpağ, Hanifi Yildiz, Talat Kiliç, Tarkan Özdemir, Pinar Yildiz Gülhan, Sulhattin Arslan, Nalan Ogan, Canan Doğan, Ümit Tutar, Şeyma Başlilar, Dorina Esendağli, Gamze Kirkil, Ömer Tamer Doğan, Ümran Toru Erbay, Aysun Ayvaci, Mustafa Tosun, Efsun Gonca Uğur Chousein, Elif Yelda Niksarlioğlu, Sabri Serhan Olcay, Tuncer Özkisa, İclal Hocanli, Mehmet Karadağ, Neslihan Özçelik, Nuray Oktay, Elvan Şentürk, Sertaç Arslan, Sibel Pekcan Özyurt, Ahu Cerit, Yasemin Nennicioğlu, Nurhan Atilla, İbrahim Halil Üney, Mehmet Fatih Elverişli, Serdar Berk, Ayşe Baha, Nur Erik, Hasan Ölmez, Berat Kaçmaz, Hüseyin Erzurumluoğlu, Ezgi Demirdöğen Çetinoğlu, Tevfik Özlü
Pulmonology is one of the branches that frequently receive consultation requests from the emergency department. Pulmonology consultation (PC) is requested from almost all clinical branches due to the diagnosis and treatment of any respiratory condition, preoperative evaluation, or postoperative pulmonary problems. The aim of our study was to describe the profile of the pulmonology consultations received from emergency departments in Turkiye. A total of 32 centers from Turkiye (the PuPCEST Study Group) were included to the study...
February 9, 2024: Medicine (Baltimore)
#34
JOURNAL ARTICLE
Vinicius Lins Costa Mello, Pedro Emmanuel Alvarenga Americano do Basil
INTRODUCTION: COVID-19 remains an important threat to global health and maintains the challenge of COVID-19 hospital care. To assist decision making regarding COVID-19 hospital care many instruments to predict COVID-19 progression to critical condition were developed and validated. OBJECTIVE: To validate eleven COVID-19 progression prediction scores for critically ill hospitalized patients in a Brazilian population. METHODOLOGY: Observational study with retrospective follow-up, including 301 adults confirmed for COVID-19 sequentially...
February 5, 2024: Brazilian Journal of Infectious Diseases
#35
REVIEW
Yuqing Liu, Xiaochu Wang, Yujuan Wen, Haoxuan Cai, Xiaoming Song, Zhipeng Zhang
In the context of global warming, increasingly widespread and frequent freezing and thawing cycles (FTCs) will have profound effects on the biogeochemical cycling of soil carbon and nitrogen. FTCs can increase soil greenhouse gas (GHG) emissions by reducing the stability of soil aggregates, promoting the release of dissolved organic carbon, decreasing the number of microorganisms, inducing cell rupture, and releasing carbon and nitrogen nutrients for use by surviving microorganisms. However, the similarity and disparity of the mechanisms potentially contributing to changes in GHGs have not been systematically evaluated...
February 3, 2024: Environmental Research
#36
JOURNAL ARTICLE
Samet Ocel, Zeynep Kekec, Omer Taskin, Fuat Belli, Mustafa Oguz Tugcan
BACKGROUND AND AIM: This study aimed to elucidate the effectiveness of bedside thoracic ultrasound according to BLUE protocol and to investigate its superiority over other imaging methods in the emergency service. METHODS: A total of 120 patients admitted to our institution's emergency care department due to respiratory distress have been enrolled in this prospective research. Thorax USG has been performed in the right and left hemithorax at the points specified in the BLUE protocol for each patient...
February 3, 2024: Irish Journal of Medical Science
#37
JOURNAL ARTICLE
Paul Boudreau, Mark Sees, Anthony Mirabito, Lisa G Chambers
Constructed treatment wetlands are commonly used to enhance surface water nutrient removal following traditional wastewater treatment. However, the constant inflow may necessitate continuous wetland inundation, leading to persistent anaerobic conditions and the accumulation of organic matter (OM) as suspended detrital flocculent (floc) and soil OM. This study investigated if temporary water level draw-down (WLDD) could promote OM consolidation and oxidation without impacting nutrient removal efficiency. A large-scale, 2-y, before-after-control-impact field experiment at the Orlando Easterly Wetland (Christmas, FL, USA) was complemented by an intact soil core laboratory experiment with varied WLDD regimes...
January 31, 2024: Science of the Total Environment
#38
Li-Li Tao, Hui-Ting Wen, Zi-Yi Wang, Juan Cheng, Li Zhao
BACKGROUND: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, highly invasive malignant neoplasm. There is no universally accepted standard of care because of its rarity and the dearth of prospective research. It is still challenging for some patients to achieve persistent clinical remission or cure, despite the success of allogeneic hematopoietic stem cell transplantation (allo-HSCT), indicating that there is still a significant recurrence rate. We report a case of prevention of BPDCN allograft recurrence by azacitidine maintenance therapy and review the relevant literature...
January 6, 2024: World Journal of Clinical Cases
#39
Koos Korsten, Josje Altenburg, Marieke Gittelbauer, Peter van Hengel, Rogier Jansen, Karin van Dijk
After having traveled to California in 2017, a 26-year old Dutch man presented in 2020 with persisting cough and shortness of breath. Radiology showed cystic bronchiectasis with peri-bronchial consolidation in his right upper lobe. Laboratory studies in August 2021 showed an increased total IgE, specific Aspergillus IgE, eosinophilia and positive BAL culture for Coccidioides immitis/posadasii . After 6 weeks of itraconazole treatment for suspected allergic bronchopulmonary aspergillosis, symptoms persisted and respiratory cultures remained positive...
March 2024: Medical Mycology Case Reports
#40
JOURNAL ARTICLE
Chloe Mighton, Abdul Noor, Nicholas Watkins, Vanessa Di Gioacchino, Jordan Lerner-Ellis, Andrew Wong, Elvira Mukharryamova, Nina Anggala, David Chitayat, Elena Greenfeld
OBJECTIVE: Chromosomal microarray (CMA), while considered the gold standard for detecting copy number variants (CNVs) in prenatal diagnostics, has its limitations, including the necessity to replace aging microarray equipment, low throughput, a static design, and an inefficient multi-day workflow. This study evaluates the feasibility of low-pass genome sequencing (LP-GS) as a potential replacement for CMA in prenatal diagnostics. METHODS: We comprehensively compared LP-GS at 10x and 5x average depths with CMA in a prenatal laboratory...
January 27, 2024: Prenatal Diagnosis
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