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https://www.readbyqxmd.com/read/28165489/the-interrelated-effect-of-sleep-and-learning-in-dogs-canis-familiaris-an-eeg-and-behavioural-study
#1
Anna Kis, Sára Szakadát, Márta Gácsi, Enikő Kovács, Péter Simor, Csenge Török, Ferenc Gombos, Róbert Bódizs, József Topál
The active role of sleep in memory consolidation is still debated, and due to a large between-species variation, the investigation of a wide range of different animal species (besides humans and laboratory rodents) is necessary. The present study applied a fully non-invasive methodology to study sleep and memory in domestic dogs, a species proven to be a good model of human awake behaviours. Polysomnography recordings performed following a command learning task provide evidence that learning has an effect on dogs' sleep EEG spectrum...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28121776/collaborative-public-health-investigation-of-clenbuterol-adulterated-heroin-outbreak-richmond-virginia-march-april-2015
#2
Brigette Gleason, Angela West, Danny Avula, Okey Utah, Marshall Vogt, Kirk Cumpston, Michael Kelly, Paul Brasler, Shane Wyatt, Laurie Forlano
CONTEXT: In March 2015, the Virginia Department of Health (VDH) was alerted by the Virginia Poison Center of a 6-patient cluster treated for severe clinical presentations after using heroin. Patients' symptoms were atypical for heroin use, and concern existed that patients were exposed to heroin that had been adulterated with or replaced by another substance. OBJECTIVE: To understand the extent and characterization of the outbreak and implement response measures to prevent further cases...
March 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28119127/antagonizing-the-different-stages-of-kappa-opioid-receptor-activation-selectively-and-independently-attenuates-acquisition-and-consolidation-of-associative-memories
#3
Ryan Loh, Lily Chau, Ali Aijaz, Kevin Wu, Roberto Galvez
Previous work from our laboratory has shown that nonspecific kappa opioid receptor (KOR) antagonism in primary somatosensory cortex (S1) can inhibit acquisition for the forebrain-dependent associative task, Whisker-Trace Eyeblink conditioning (WTEB). Although studies have demonstrated that KOR activation can alter stimuli salience, our studies controlled for these factors, demonstrating that KOR also plays a role in facilitating learning. KOR has two distinct phases of activation followed by internalization/downregulation, that each independently activate kinases and transcription factors known to mediate task acquisition and memory consolidation respectively...
April 14, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28115369/angioimmunoblastic-t-cell-lymphoma-the-many-faced-lymphoma
#4
Matthew A Lunning, Julie M Vose
Angioimmunoblastic T-cell lymphoma (AITL) is an uncommon subtype of mature peripheral T-cell lymphoma (PTCL). The history of AITL is much longer and deeper than the literature would suggest given the many names that has preceded it. Advanced stage disease is common with uncharacteristic laboratory and autoimmune findings that often slow or mask the diagnosis. Significant strides in the immunohistochemical and molecular signature of AITL have brought increased ability to diagnose this uncommon type of PTCL. The 2016 World Health Organization (WHO) classification of lymphoid neoplasms recently acknowledged the complexity of this diagnosis with the addition of other AITL-like subsets...
January 23, 2017: Blood
https://www.readbyqxmd.com/read/28114362/clinical-features-and-courses-of-adenovirus-pneumonia-in-healthy-young-adults-during-an-outbreak-among-korean-military-personnel
#5
Ji Young Park, Bong-Joon Kim, Eun Jung Lee, Kwi Sung Park, Hee Sun Park, Sung Soo Jung, Ju Ock Kim
BACKGROUND: The number of pneumonia patients increased suddenly in Korean military hospitals in late December 2014, indicating the urgent need for an epidemic outbreak investigation. METHODS: We conducted a prospective study of pneumonia etiology among immunocompetent young adults admitted to Daejeon Armed Forces hospital. Patient blood and sputum samples were subjected to conventional culture, serology, and polymerase chain reaction tests for respiratory viruses and atypical pathogens...
2017: PloS One
https://www.readbyqxmd.com/read/28100279/severe-community-acquired-adenovirus-pneumonia-treated-with-oral-ribavirin-a-case-report
#6
Byung Woo Yoon, Yong Geon Song, Seung Hyeun Lee
BACKGROUND: Adenovirus is a common pathogen of acute upper respiratory infection in children and is generally self-limiting. Severe adenovirus infections have been reported in immunocompromised hosts especially bone marrow transplantation recipients due to hematologic malignancy. Severe adenovirus pneumonia in immunocompetent hosts has rarely been reported and optimal treatment has not been established. We report a case of community-acquired severe adenovirus pneumonia which was successfully treated with early administration of oral ribavirin...
January 18, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28079811/routine-application-of-lung-ultrasonography-in-the-neonatal-intensive-care-unit
#7
Shui-Wen Chen, Wei Fu, Jing Liu, Yan Wang
The aim of this study was to study the features of lung ultrasonography (LUS) in lung disease and to evaluate the usefulness of LUS in the neonatal intensive care unit (NICU).All of 3405 neonates included in this study underwent an LUS examination. Diagnoses were based on medical history, clinical manifestation, laboratory examination, and signs on chest radiography (CR) and/or computed tomography (CT). A single expert physician performed all LUS examinations.There were 2658 cases (78.9%) with lung disease and 747 cases (21...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28076011/pulmonary-tuberculosis-role-of-radiology-in-diagnosis-and-management
#8
Arun C Nachiappan, Kasra Rahbar, Xiao Shi, Elizabeth S Guy, Eduardo J Mortani Barbosa, Girish S Shroff, Daniel Ocazionez, Alan E Schlesinger, Sharyn I Katz, Mark M Hammer
Tuberculosis is a public health problem worldwide, including in the United States-particularly among immunocompromised patients and other high-risk groups. Tuberculosis manifests in active and latent forms. Active disease can occur as primary tuberculosis, developing shortly after infection, or postprimary tuberculosis, developing after a long period of latent infection. Primary tuberculosis occurs most commonly in children and immunocompromised patients, who present with lymphadenopathy, pulmonary consolidation, and pleural effusion...
January 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28068804/annals-express-a-practical-tool-for-monitoring-the-performance-of-measuring-systems-in-a-laboratory-network-report-of-an-acb-working-group
#9
Pete Ayling, Robert Patrick Hill, Nuthar Jassam, Anders Kallner, Zahra Khatami
BACKGROUND A logical consequence of the introduction of robotics and high capacity analysers has seen a consolidation to larger units. This requires new structures and quality systems to ensure that laboratories deliver consistent and comparable results. METHODS A spreadsheet program was designed to accommodate results from up to 12 different Instruments/laboratories and present IQC data i.e. Levey-Jennings and Youden plots and comprehensive numerical tables of the performance of each item. Input of data was made possible by a "data loader" by which IQC data from the individual instruments could be transferred to the spreadsheet program on line...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28050475/role-of-hrct-chest-in-post-stem-cell-transplant-recipients-suspected-of-pulmonary-complications
#10
Abhishek Dwivedi, R Ravi Kumar, Ajay Sharma, S K Pannu
INTRODUCTION: Stem cell transplantation is today's procedure of choice for management of various hematopoietic malignant and severe immunogenic disorders. High Resolution Computed Tomography (HRCT) is a common technique for the diagnosis of pulmonary complications in stem cell transplant recipients. There are a large number of complications which can complicate the post-transplant period. AIM: To study the role of HRCT chest in stem cell transplant patients developing pulmonary complications, detect any evidence of infection, detect clinical signs of lung infections, Graft versus Host Disease (GvHD) or other regimen related toxicities outlined earlier, detect any evidence of GvHD and correlate these clinical signs with radiological changes in the lungs...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28049240/characteristics-of-adenovirus-pneumonia-in-korean-military-personnel-2012-2016
#11
Hee Yoon, Byung Woo Jhun, Hojoong Kim, Hongseok Yoo, Sung Bum Park
Adenovirus (AdV) can cause severe pneumonia in non-immunocompromised host, but limited data exist on the distinctive characteristics of AdV pneumonia in non-immunocompromised patients. We evaluated distinctive clinico-laboratory and radiological characteristics and outcomes of AdV pneumonia (n = 179), compared with non-AdV pneumonia (n = 188) in Korean military personnel between 2012 and 2016. AdV pneumonia patients had a higher rate of consolidation with ground-glass opacity (101/152) in lobar distribution (89/152) on computed tomography (CT) (P < 0...
February 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28043529/relation-between-smear-positivity-and-imaging-findings-in-children-with-pulmonary-tuberculosis
#12
Maryam Hassanzad, Mohammad Reza Bolursaz, Payam Mehrian, Farahnaz Aghahosseini, Ali Akbar Velayati
OBJECTIVE/BACKGROUND: We investigated the relationship between high-resolution computed tomography (HRCT) imaging manifestation of tuberculosis (TB) in childhood and the results of sputum smear. The aim of this study was to identify an alternative indicator of infectivity to prevent disease transmission through special isolation methods in children who have a clinical condition that suggests TB. METHODS: This retrospective comparative study was performed on 95 children under the age of 15years with a diagnosis of TB based on World Health Organization criteria and laboratory data (smear and culture positive for Mycobacterium tuberculosis)...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28031206/physiological-differences-in-cryptococcus-neoformans-strains-in-vitro-versus-in-vivo-and-their-effects-on-antifungal-susceptibility
#13
REVIEW
Nina T Grossman, Arturo Casadevall
Cryptococcus neoformans is an environmentally ubiquitous fungal pathogen that primarily causes disease in people with compromised immune systems, particularly those with advanced AIDS. There are estimated to be almost 1 million cases per year of cryptococcal meningitis in patients infected with human immunodeficiency virus, leading to over 600,000 annual deaths, with a particular burden in sub-Saharan Africa. Amphotericin B (AMB) and fluconazole (FLC) are key components of cryptococcal meningitis treatment: AMB is used for induction, and FLC is for consolidation, maintenance and, for occasional individuals, prophylaxis...
March 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27995869/evaluation-of-xpert-mrsa-gen-3-and-bd-max-mrsa-xt-for-meticillin-resistant-staphylococcusaureus-screening-in-a-routine-diagnostic-setting-in-a-low-prevalence-area
#14
Xiaohui Chen Nielsen, Tina Vasehus Madsen, Jørgen Engberg
Screening and pre-emptive isolation of at-risk patients are important aspects of the Danish approach to the prevention of meticillin-resistant Staphylococcusaureus (MRSA) infection, but screening with conventional culture can take up to 3 days for results to become available with attendant costs and disadvantages of prolonged isolation. We sought to evaluate the accuracy, time to availability of results and potential economic benefits of two next-generation MRSA screening assays, Xpert MRSA Gen 3 (GX MRSA) and BD MAX MRSA XT, in a setting of a consolidated laboratory serving a number of hospitals with a low prevalence of MRSA and using enrichment culture as a reference method...
January 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27982665/building-health-it-capacity-to-improve-hiv-infection-health-outcomes
#15
Hannah Rettler, Monina Klevens, Gillian Haney, Liisa Randall, Alfred DeMaria, Johanna Goderre
Eighty-six percent of those engaged in HIV medical care in Massachusetts achieved viral suppression, making Massachusetts's long-term goal of eliminating new infections of HIV a real possibility. In order to achieve this goal, Massachusetts is working to engage all individuals living with HIV/AIDS in HIV medical care, keep them retained in care, and render their viral load non-detectable. Currently, in Massachusetts, the data elements necessary to monitor the HIV care continuum are documented in siloed health information systems that do not communicate with each other...
December 2016: American Journal of Managed Care
https://www.readbyqxmd.com/read/27982330/bariatric-surgery-is-it-reasonable-before-the-age-of-16
#16
Lilian Helena Polak Massabki, Letícia Esposito Sewaybricker, Keila Hayashi Nakamura, Roberto Teixeira Mendes, Antonio DE Azevedo Barros, Maria Ângela Reis DE Góes Monteiro Antonio, Mariana Porto Zambon
Objective: to assess the severity of obesity in children and adolescents through the presence of comorbidities and the potential indication of bariatric surgery. Methods: we conducted a cross-sectional study with clinical and laboratory data of the first consultation of patients at the childhood obesity clinic at a tertiary hospital from 2005 to 2013. We divided the patients into groups with or without potential indication for surgery, and recorded age, gender, birth weight, age of obesity onset, BMI Z score, presence of acanthosis nigricans, blood pressure, total cholesterol and fractions, triglycerides, blood glucose and fasting insulin, HOMA1-IR, CRP and ESR...
September 2016: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/27906037/integrated-therapy-for-hiv-and-cryptococcosis
#17
REVIEW
Sirawat Srichatrapimuk, Somnuek Sungkanuparph
Cryptococcosis has been one of the most common opportunistic infections and causes of mortality among HIV-infected patients, especially in resource-limited countries. Cryptococcal meningitis is the most common form of cryptococcosis. Laboratory diagnosis of cryptococcosis includes direct microscopic examination, isolation of Cryptococcus from a clinical specimen, and detection of cryptococcal antigen. Without appropriate treatment, cryptococcosis is fatal. Early diagnosis and treatment is the key to treatment success...
November 29, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27845027/clinical-effectiveness-and-cost-effectiveness-of-use-of-therapeutic-monitoring-of-tumour-necrosis-factor-alpha-tnf-%C3%AE-inhibitors-lisa-tracker%C3%A2-enzyme-linked-immunosorbent-assay-elisa-kits-tnf-%C3%AE-blocker-elisa-kits-and-promonitor%C3%A2-elisa-kits-versus-standard-care
#18
Karoline Freeman, Martin Connock, Peter Auguste, Sian Taylor-Phillips, Hema Mistry, Deepson Shyangdan, Rachel Court, Ramesh Arasaradnam, Paul Sutcliffe, Aileen Clarke
BACKGROUND AND OBJECTIVES: Systematic reviews and economic modelling of clinical effectiveness and cost-effectiveness of therapeutic monitoring of tumour necrosis factor alpha (TNF-α) inhibitors [using LISA-TRACKER(®) enzyme-linked immunosorbent assay (ELISA) kits (Theradiag, Marne La Vallee, France, or Alpha Laboratories, Heriot, UK), TNF-α-Blocker ELISA kits (Immundiagnostik AG, Bensheim, Germany) and Promonitor(®) ELISA kits (Proteomika, Progenika Biopharma, Bizkaia, Spain)] versus standard care for Crohn's disease (CD)...
November 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27843856/induced-sputum-versus-bronchial-washings-in-the-diagnosis-of-sputum-negative-pulmonary-tuberculosis
#19
Gopathi Nageswar Rao, Mandava Venu, Namballa Usha Rani, Makala Sravani
INTRODUCTION: Tuberculosis (TB) is one of the most important public health problems worldwide. Detecting patients with active pulmonary TB (PT) is an important component of TB control programs. However, at times in patients even with a compatible clinical picture, sputum smears do not reveal acid-fast bacilli (AFB) and smear-negative PT remains a common problem. This study compares the results of induced sputum (IS) and bronchial washings (BWs) in detecting sputum negative PT. MATERIALS AND METHODS: A prospective study conducted from June 2014 to June 2015, comprising 120 patients fulfilling study criteria...
April 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/27825991/cyp24a1-deficiency-does-not-affect-bone-regeneration-in-distraction-osteogenesis
#20
REVIEW
Abdallah Husseini, René St-Arnaud
The putative biological activity of 24,25-(OH)2D remains unclear. Previous studies showed an increase in the circulating levels of this metabolite following fracture in chicks. Our laboratory has generated a mouse model deficient for the Cyp24a1 gene for studying the role of 24,25-(OH)2D. We set out to study the role of CYP24A1 and 24,25-(OH)2D in intramembranous bone formation during distraction osteogenesis in wild-type and Cyp24a1-deficient mice. Distraction osteogenesis was applied to mouse tibiae using a miniature external fixator apparatus...
November 5, 2016: Journal of Steroid Biochemistry and Molecular Biology
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