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https://www.readbyqxmd.com/read/29656520/first-attempt-of-glycidol-to-monoalkyl-glyceryl-ethers-by-acid-heterogeneous-catalysis-synthesis-and-simplified-sustainability-assessment
#1
Maria Ricciardi, Fabrizio Passarini, Carmine Capacchione, Antonio Proto, Joel Barrault, Raffaele Cucciniello, Daniele Cespi
The selective preparation of monoalkylglyceryl ethers (MAGEs) is an active task of research due to their broad range of applications. In this work, green feedstocks such as glycidol and alcohols were used to prepare MAGEs under mild reaction conditions (80°C, 3h, 0.5% in moles of catalyst) in the presence of acid heterogeneous catalysts. Nafion shows the best performances in terms of conversion and selectivity to MAGES and also high stability. A comparison of the environmental performances with the most consolidated pathway from glycerol has shown that the usage of glycidol (recovered as value-added product from Epicerol® process) and Nafion leads to lower impacts on ecosystems...
April 14, 2018: ChemSusChem
https://www.readbyqxmd.com/read/29649263/validation-of-czecanca-czech-cancer-panel-for-clinical-application-for-targeted-ngs-based-analysis-of-hereditary-cancer-syndromes
#2
Jana Soukupova, Petra Zemankova, Klara Lhotova, Marketa Janatova, Marianna Borecka, Lenka Stolarova, Filip Lhota, Lenka Foretova, Eva Machackova, Viktor Stranecky, Spiros Tavandzis, Petra Kleiblova, Michal Vocka, Hana Hartmannova, Katerina Hodanova, Stanislav Kmoch, Zdenek Kleibl
BACKGROUND: Carriers of mutations in hereditary cancer predisposition genes represent a small but clinically important subgroup of oncology patients. The identification of causal germline mutations determines follow-up management, treatment options and genetic counselling in patients' families. Targeted next-generation sequencing-based analyses using cancer-specific panels in high-risk individuals have been rapidly adopted by diagnostic laboratories. While the use of diagnosis-specific panels is straightforward in typical cases, individuals with unusual phenotypes from families with overlapping criteria require multiple panel testing...
2018: PloS One
https://www.readbyqxmd.com/read/29590190/minerosion-3-using-measurements-on-a-tilting-flume-rainfall-simulator-facility-to-predict-erosion-rates-from-post-mining-landscapes-in-central-queensland-australia
#3
Hwat Bing So, Ashraf M Khalifa, Bofu Yu, Chris Caroll, Peter Burger, David Mulligan
Open-cut coal mining in Queensland results in the formation of extensive saline overburden spoil-piles with steep slopes at the angle of repose (approximately 75% or 37o). These spoil-piles are generally found in multiple rows, several kilometers in length and heights of up to 50 or 60 m above the original landscape. They are highly dispersive and erodible. Legislation demands that these spoil piles be rehabilitated to minimize on-site and off-site discharges of sediment and salt into the surrounding environment...
2018: PloS One
https://www.readbyqxmd.com/read/29581924/distinguishing-pediatric-lyme-arthritis-of-the-hip-from-transient-synovitis-and-acute-bacterial-septic-arthritis-a-systematic-review-and-meta-analysis
#4
Aristides I Cruz, Jason B Anari, Jose M Ramirez, Wudbhav N Sankar, Keith D Baldwin
Objective Lyme arthritis is an increasingly recognized clinical entity that often prompts orthopaedic evaluation in pediatric patients. While Lyme arthritis is most common in the knee, the clinical presentation of Lyme arthritis of the hip can be similar to both acute bacterial septic arthritis and transient synovitis. Accurately distinguishing these clinical entities is important since the definitive treatment of each is distinct. Because there is limited literature on monoarticular Lyme arthritis of the hip, the purpose of this study was to perform a systematic review and meta-analysis of clinical and laboratory parameters associated with Lyme arthritis (LA) of the hip and compare them to septic arthritis (SA) and transient synovitis (TS)...
January 25, 2018: Curēus
https://www.readbyqxmd.com/read/29578499/processing-of-bulk-nanocrystalline-metals-at-the-us-army-research-laboratory
#5
Vincent H Hammond, Billy C Hornbuckle, Anit K Giri, Anthony J Roberts, Thomas L Luckenbaugh, Joseph M Marsico, Scott M Grendahl, Kristopher A Darling
Given their potential for significant property improvements relative to their large grained counterparts, much work has been devoted to the continued development of nanocrystalline metals. Despite these efforts, the transition of these materials from the lab bench to actual applications has been blocked by the inability to produce large scale parts that retain the desired nanocrystalline microstructures. Following the development of a method proven to stabilize the nanosized grain structure to temperatures approaching that of the melting point for the given metal, the US Army Research Laboratory (ARL) has progressed to the next stage in the development of these materials - namely the production of large scale parts suitable for testing and evaluation in a range of relevant test environments...
March 7, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29555008/using-cageside-measures-to-evaluate-analgesic-efficacy-in-mice-mus-musculus-after-surgery
#6
Vanessa L Oliver, Sarah E Thurston, Jennifer L Lofgren
Recent studies have revealed some of the most frequently used analgesics in mice are not effectively treating postoperative pain. Our laboratory sought to compare and assess the validity and reliability of 2 cageside pain assessments that we recently developed for use in mice-nesting consolidation and grooming transfer tests. We then applied these tests to compare the efficacy of commonly used analgesics-buprenorphine (0.1 mg/kg SC every 12 h for 48 h) and carprofen (30 mg/kg in drinking water for 72 h)-alone and in multimodal combination as a refinement for treating postoperative pain in mice...
March 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29535097/a-case-of-tricuspid-valve-non-bacterial-thrombotic-endocarditis-presenting-as-pulmonary-embolism-in-a-patient-with-antiphospholipid-antibody-syndrome
#7
Dileep Unnikrishnan, Nasreen Shaikh, Ahmad Sharayah, Chandler Patton
A 47-year-old woman with a medical history of Raynaud's phenomenon presented with fever, cough and shortness of breath. She was found to have left lower lobe consolidation and pleural effusion and was treated as a case of pneumonia. During the hospital course, her respiratory status worsened, and she was intubated on the third hospital day. To investigate the high A-a gradient, a Computerized Tomographic Pulmonary Embolism (CTPE) study was done which identified a large left lower pulmonary artery embolism. She was also found to have a new murmur, and an echocardiogram demonstrated a large lesion on tricuspid valve...
March 13, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29500081/laboratory-studies-on-effect-of-fiber-content-on-dynamic-characteristics-of-municipal-solid-waste
#8
P Alidoust, M Keramati, N Shariatmadari
The dynamic characterization of municipal solid waste (MSW), especially in regions with high seismicity, is of considerable importance in the stability assessment of landfills. Additionally, findings indicated that the response of MSW under dynamic loadings is significantly affected by fibrous material. Therefore, a comprehensive strain-controlled cyclic triaxial testing program was performed on MSW samples retrieved from a landfill in the Kahrizak area, Tehran province. The tests were conducted on fresh MSW specimens (with a diameter of 100 mm) with different percentage of fibers in the consolidated undrained condition...
February 27, 2018: Waste Management
https://www.readbyqxmd.com/read/29485125/plant-reference-genes-for-development-and-stress-response-studies
#9
Joyous T Joseph, Najya Jabeen Poolakkalody, Jasmine M Shah
Many reference genes are used by different laboratories for gene expression analyses to indicate the relative amount of input RNA/DNA in the experiment. These reference genes are supposed to show least variation among the treatments and with the control sets in a given experiment. However, expression of reference genes varies significantly from one set of experiment to the other. Thus, selection of reference genes depends on the experimental conditions. Sometimes the average expression of two or three reference genes is taken as standard...
March 2018: Journal of Biosciences
https://www.readbyqxmd.com/read/29481684/on-tour-with-the-prince-monarchy-imperial-politics-and-publicity-in-the-prince-of-wales-s-dominion-tours-1919-20
#10
Frank Mort
The stage managers of ritual and the media transformed the British monarchy in the late-nineteenth and early-twentieth century, consolidating its image as splendid and popular and also as more accessible and quasi-democratic. Historians have emphasized that these processes of modernization largely began in Britain. This article locates the origins of democratized royal ritual in the white dominions, especially after 1918. Canada, Australia and New Zealand were political and cultural laboratories where royal advisors and British and dominion politicians launched experiments in the practice of progressive empire and innovatory styles of informal ceremonial, which had a long-term impact on imperial and later Commonwealth relations...
March 1, 2018: 20 Century British History
https://www.readbyqxmd.com/read/29457001/control-of-infectious-diseases-in-the-era-of-european-clinical-microbiology-laboratory-consolidation-new-challenges-and-opportunities-for-the-patient-and-for-public-health-surveillance
#11
Olivier Vandenberg, Zisis Kozlakidis, Jacques Schrenzel, Marc Jean Struelens, Judith Breuer
Many new innovative diagnostic approaches have been made available during the last 10 years with major impact on patient care and public health surveillance. In parallel, to enhance the cost-effectiveness of the clinical microbiology laboratories (CMLs), European laboratory professionals have streamlined their organization leading to amalgamation of activities and restructuring of their professional relationships with clinicians and public health specialists. Through this consolidation process, an operational model has emerged that combines large centralized clinical laboratories performing most tests on one high-throughput analytical platform connected to several distal laboratories dealing locally with urgent analyses at near point of care...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29439875/consensus-document-on-the-implementation-of-next-generation-sequencing-in-the-genetic-diagnosis-of-hereditary-cancer
#12
José Luis Soto, Ignacio Blanco, Orland Díez, Javier García Planells, Isabel Lorda, Gert Matthijs, Mercedes Robledo, Erika Souche, Conxi Lázaro
Genetic diagnosis of hereditary cancer syndromes offers the opportunity to establish more effective predictive and preventive measures for the patient and their families. The ultimate objective is to decrease cancer morbidity and mortality in high genetic risk families. Next Generation Sequencing (NGS) offers an important improvement in the efficiency of genetic diagnosis, allowing an increase in diagnostic yield with a substantial reduction in response times and economic costs. Consequently, the implementation of this new technology is a great opportunity for improvement in the clinical management of affected families...
February 10, 2018: Medicina Clínica
https://www.readbyqxmd.com/read/29427552/quality-and-future-of-clinical-laboratories-the-vico-s-whole-cyclical-theory-of-the-recurring-cycles
#13
Mario Plebani
In the last few decades, laboratory medicine has undergone monumental changes, and laboratory technology, which has made enormous advances, now has new clinical applications thanks to the identification of a growing number of biomarkers and risk factors conducive to the promotion of predictive and preventive interventions that have enhanced the role of laboratory medicine in health care delivering. However, the paradigm shift in the past 50 years has led to a gap between laboratory and clinic, with an increased risk of inappropriateness in test request and interpretation, as well as the consolidation of analytical work in focused factories and megastructurers oriented only toward achieving greater volumes, decreasing cost per test and generating a vision of laboratory services as simple commodities...
February 10, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29425378/government-cloud-computing-policies-potential-opportunities-for-advancing-military-biomedical-research
#14
Frank J Lebeda, Jeffrey J Zalatoris, Julia B Scheerer
Introduction: This position paper summarizes the development and the present status of Department of Defense (DoD) and other government policies and guidances regarding cloud computing services. Due to the heterogeneous and growing biomedical big datasets, cloud computing services offer an opportunity to mitigate the associated storage and analysis requirements. Having on-demand network access to a shared pool of flexible computing resources creates a consolidated system that should reduce potential duplications of effort in military biomedical research...
February 7, 2018: Military Medicine
https://www.readbyqxmd.com/read/29386890/phenotyping-copd-exacerbations-using-imaging-and-blood-based-biomarkers
#15
Nawaf M Alotaibi, Virginia Chen, Zsuzsanna Hollander, Cameron J Hague, Darra T Murphy, Jonathon A Leipsic, Mari L DeMarco, J Mark FitzGerald, Bruce M McManus, Raymond T Ng, Don D Sin
Rationale: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are caused by a variety of different etiologic agents. Our aim was to phenotype COPD exacerbations using imaging (chest X-ray [CXR] and computed tomography [CT]) and to determine the possible role of the blood tests (C-reactive protein [CRP], the N-terminal prohormone brain natriuretic peptide [NT-proBNP]) as diagnostic biomarkers. Materials and methods: Subjects who were hospitalized with a primary diagnosis of AECOPD and who had had CXRs, CT scans, and blood collection for CRP and NT-proBNP were assessed in this study...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29380127/pathologist-s-assistant-patha-and-his-her-role-in-the-surgical-pathology-department-a-systematic-review-and-a-narrative-synthesis
#16
M Bortesi, V Martino, M Marchetti, A Cavazza, G Gardini, E Zanetti, M C Bassi, L Ghirotto, M Costantini, Simonetta Piana
In recent decades, various highly qualified individuals have increasingly performed tasks that have historically been handled by physicians with the aim of reducing their workload. Over time, however, these "physician assistants" or "physician extenders" have gained more and more responsibilities, showing that specific tasks can be performed equally skilfully by specialised health care professionals. The pathologist's assistant (PathA) is a highly qualified technician who works alongside the pathologist and is responsible for the grossing and autopsies...
January 29, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29357046/translational-neonatology-research-transformative-encounters-across-species-and-disciplines
#17
Mie S Dam, Per T Sangild, Mette N Svendsen
This paper explores the laborious and intimate work of turning bodies of research animals into models of human patients. Based on ethnographic research in the interdisciplinary Danish research centre NEOMUNE, we investigate collaboration across species and disciplines, in research aiming at improving survival for preterm infants. NEOMUNE experimental studies on piglets evolved as a platform on which both basic and clinical scientists exercised professional authority. Guided by the field of multi-species research, we explore the social and material agency of research animals in the production of human health...
January 22, 2018: History and Philosophy of the Life Sciences
https://www.readbyqxmd.com/read/29352032/the-surprising-subtleties-of-changing-fear-memory-a-challenge-for-translational-science
#18
REVIEW
Merel Kindt
Current pharmacological and psychological treatments for disorders of emotional memory only dampen the affective response while leaving the original fear memory intact. Under adverse circumstances, these original memories regain prominence, causing relapses in many patients. The (re)discovery in neuroscience that after reactivation consolidated fear memories may return to a transient labile state, requiring a process of restabilization in order to persist, offers a window of opportunity for modifying fear memories with amnestic agents...
March 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29337314/the-reconstruction-of-2-631-draft-metagenome-assembled-genomes-from-the-global-oceans
#19
Benjamin J Tully, Elaina D Graham, John F Heidelberg
Microorganisms play a crucial role in mediating global biogeochemical cycles in the marine environment. By reconstructing the genomes of environmental organisms through metagenomics, researchers are able to study the metabolic potential of Bacteria and Archaea that are resistant to isolation in the laboratory. Utilizing the large metagenomic dataset generated from 234 samples collected during the Tara Oceans circumnavigation expedition, we were able to assemble 102 billion paired-end reads into 562 million contigs, which in turn were co-assembled and consolidated in to 7...
January 16, 2018: Scientific Data
https://www.readbyqxmd.com/read/29249946/moderate-partially-reduplicated-conditioned-stimuli-as-retrieval-cue-can-increase-effect-on-preventing-relapse-of-fear-to-compound-stimuli
#20
Junjiao Li, Wei Chen, Jingwen Caoyang, Wenli Wu, Jing Jie, Liang Xu, Xifu Zheng
The theory of memory reconsolidation argues that consolidated memory is not unchangeable. Once a memory is reactivated it may go back into an unstable state and need new protein synthesis to be consolidated again, which is called "memory reconsolidation". Boundary studies have shown that interfering with reconsolidation through pharmacologic or behavioral intervention can lead to the updating of the initial memory, for example, erasing undesired memories. Behavioral procedures based on memory reconsolidation interference have been shown to be an effective way to inhibit fear memory relapse after extinction...
2017: Frontiers in Human Neuroscience
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