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Zolpidem

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https://www.readbyqxmd.com/read/28207998/benzodiazepine-and-z-drug-dependence-data-from-a-tertiary-care-center
#1
Lekhansh Shukla, Spandana Bokka, Tulika Shukla, Arun Kandasamy, Prabhat Chand, Vivek Benegal, Pratima Murthy
Objective: To examine the clinical characteristics and course of benzodiazepine and �Z-drug� dependence in patients presenting to a tertiary deaddiction center in southern India. Methods: Case files of 950 inpatients admitted between January 2007 and January 2014 who reported benzodiazepine or Z-drug use were reviewed. Patients (n = 170) with an ICD-10 diagnosis of mental and behavioral disorders due to the use of sedatives or hypnotics-dependence syndrome currently using substance (F13...
February 16, 2017: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/28181568/predictive-modeling-of-physician-patient-dynamics-that-influence-sleep-medication-prescriptions-and-clinical-decision-making
#2
Andrew L Beam, Uri Kartoun, Jennifer K Pai, Arnaub K Chatterjee, Timothy P Fitzgerald, Stanley Y Shaw, Isaac S Kohane
Insomnia remains under-diagnosed and poorly treated despite its high economic and social costs. Though previous work has examined how patient characteristics affect sleep medication prescriptions, the role of physician characteristics that influence this clinical decision remains unclear. We sought to understand patient and physician factors that influence sleep medication prescribing patterns by analyzing Electronic Medical Records (EMRs) including the narrative clinical notes as well as codified data. Zolpidem and trazodone were the most widely prescribed initial sleep medication in a cohort of 1,105 patients...
February 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28162647/-403-co-administration-of-mirogabalin-and-zolpidem-in-healthy-subjects-results-from-a-randomized-double-blind-drug-drug-interaction-study
#3
M Jansen, D Merante, A Currie, M Velinova, K Brown, H Zahir
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28106623/symptom-presentation-and-prescription-of-sleep-medications-for-veterans-with-posttraumatic-stress-disorder
#4
Mark A Greenbaum, Thomas C Neylan, Craig S Rosen
This study tested whether sleep medications prescribed to veterans diagnosed with posttraumatic stress disorder (PTSD) are being targeted to patients who report more severe insomnia or nightmares. Secondary analysis of survey and pharmacy data was conducted in samples of veterans from two periods: from 2006 to 2008 and from 2009 to 2013. Logistic regression tested associations between self-reported insomnia and nightmare severity, and being prescribed trazodone, prazosin, zolpidem, and benzodiazepines, controlling for PTSD severity and other covariates...
February 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28101753/effect-and-safety-of-paroxetine-combined-with-zolpidem-in-treatment-of-primary-insomnia
#5
Z H Yu, X H Xu, S D Wang, M F Song, Y Liu, Y Yin, H J Mao, G Z Tang
PURPOSE: Primary insomnia is a persistent and recurrent disorder as well as a risk factor for depression. The aim of this study was to determine whether the zolpidem combined with paroxetine would be effective in the treatment of patients with primary insomnia. METHODS: Ninety patients meeting DSM-IV criteria for primary insomnia were randomly assigned to 8 weeks of treatment with zolpidem combined with paroxetine (the combined treatment group, n = 45) or zolpidem combined with placebo (the control group, n = 45)...
January 18, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28099356/increased-risk-of-parkinson-disease-with-diabetes-mellitus-in-a-population-based-study
#6
Yu-Wan Yang, Teng-Fu Hsieh, Chia-Ing Li, Chiu-Shong Liu, Wen-Yuan Lin, Jen-Huai Chiang, Tsai-Chung Li, Cheng-Chieh Lin
This nationwide population-based study investigated the risk of Parkinson disease (PD) in relation to diabetes mellitus (DM) through the National Health Insurance Research Database in Taiwan.A retrospective study was conducted, consisting of 36,294 patients who were newly diagnosed with DM between January 1, 2000 and December 31, 2006 and 108,882 individuals without DM as healthy controls from insurance claims data from Taiwan's National Health Research Institutes Dataset. The subjects were followed up until December 31, 2011 or until the first manifestation of PD...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28094153/development-and-validation-of-a-fast-ionic-liquid-based-dispersive-liquid-liquid-microextraction-procedure-combined-with-lc-ms-ms-analysis-for-the-quantification-of-benzodiazepines-and-benzodiazepine-like-hypnotics-in-whole-blood
#7
Marieke De Boeck, Sophie Missotten, Wim Dehaen, Jan Tytgat, Eva Cuypers
To date, thorough clean-up of complex biological samples remains an essential part of the analytical process. The solid phase extraction (SPE) technique is the well-known standard, however, its main weaknesses are the labor-intensive and time-consuming protocols. In this respect, dispersive liquid-liquid microextractions (DLLME) seem to offer less complex and more efficient extraction procedures. Furthermore, ionic liquids (ILs) - liquid salts - are emerging as new promising extraction solvents, thanks to their non-flammable nature, negligible vapor pressure and easily adaptable physiochemical properties...
December 26, 2016: Forensic Science International
https://www.readbyqxmd.com/read/28093373/improved-arousal-and-motor-function-using-zolpidem-in-a-patient-with-space-occupying-intracranial-lesions-a-case-report
#8
Martin Nicholas Bomalaski, Sean Robinson Smith
: Patients with disorders of consciousness (DOC) have profound functional limitations with few treatment options for improving arousal and quality of life. Zolpidem is a nonbenzodiazepine hypnotic used to treat insomnia that has also been observed to paradoxically improve arousal in those with DOC, such as the vegetative or minimally conscious states. Little information exists on its use in patients with DOC who have intracranial space-occupying lesions. We present a case of a 24-year-old man in a minimally conscious states due to central nervous system lymphoma who was observed to have increased arousal and improved motor function after the administration of zolpidem...
January 16, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28079530/can-intoxication-status-be-used-as-a-prediction-tool-for-manner-of-death-a-comparison-of-the-intoxication-status-in-violent-suicides-and-homicides
#9
D Kimberley Molina, Veronica M Hargrove
Determining the manner of death in medicolegal death investigations can be difficult. The investigator relies on many facets of death investigation, including the circumstances of death and autopsy examination. A study was designed to analyze whether the intoxication status of the decedent could be used as another tool in death investigations. The intoxication status of violent (nonoverdose or poisoning) suicides and homicides was retrospectively reviewed and compared. A total of 625 deaths were identified, including 366 suicides and 259 homicides...
March 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28077205/impact-of-pharmacists-in-optimizing-geriatric-pharmacotherapy-in-primary-care-within-a-veterans-affairs-medical-center
#10
Taryn B Mondiello, Lauren A Stutzman
OBJECTIVE: To assess pharmacists' impact on optimizing pharmacotherapy among geriatric patients. DESIGN: Single-site, prospective, quality-improvement project. SETTING: Primary care at a Veterans Affairs medical center. PARTICIPANTS: Thirteen males 75 years of age and older were included. INTERVENTIONS: Recommendations were made by pharmacists to optimize prescribing. MAIN OUTCOME MEASURES: Differences between specific instances of suboptimal prescribing before and after pharmacists' recommendations, the percentage of pharmacists' recommendations accepted, and the top most commonly prescribed psychotropic medications and their most common indications...
January 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28075519/an-update-of-management-of-insomnia-in-patients-with-chronic-orofacial-pain
#11
REVIEW
Galit Almoznino, Yaron Haviv, Yair Sharav, Rafael Benoliel
In this review we discuss the management of chronic orofacial pain (COFP) patients with insomnia. Diagnostic work-up and follow-up routines of COFP patients should include assessment of sleep problems. Management is based on a multidisciplinary approach, addressing the factors that modulate the pain experience as well as insomnia and including both non-pharmacological and pharmacological modalities. Parallel to treatment, patients should receive therapy for co-morbid medical and psychiatric disorders, and possible substance abuse that may be that may trigger or worsen the COFP and/or their insomnia...
January 11, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28067201/false-negative-on-a-proven-involuntary-intoxication-in-two-children-with-lorazepam
#12
Catherine Feliu, Hélène Guillemin, Claire Gozalo, Aurélie Fouley, Hélène Marty, Hervé Millart, Zoubir Djerada
Children aged between 1 to 4 years are the most at risk of unintentional poisonings. Benzodiazepines are the most medicine often cause of the poisoning. Among the twenty-two most prescribed benzodiazepines in France, lorazepam ranks fifth behind zolpidem, alprazolam, bromazepam and zopiclone. However the automated assay currently available does not allow to detect and/or to quantify lorazepam. The alternative to the immunoassay is the liquid chromatography coupled with mass spectrometry (HPLC/MS). This technique, highly sensitive and specific, requires a pre-treatment phase and a good technical proficiency, justifying specialized staff...
January 9, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/28067180/dispensing-patterns-of-anxiolytics-and-sedative-hypnotics-a-feasibility-study-comparing-datasets-from-a-developed-and-developing-country-australia-and-south-africa
#13
Therése Kairuz, Ilse Truter, Laurence Rossato, Alex Pudmenzky
BACKGROUND: Dispensing patterns reflect drug usage trends. Benzodiazepines are known as drugs with potential for misuse, and frequent dispensing may be a surrogate marker of misuse. OBJECTIVE: The primary aim of this study was to obtain a comparative snapshot of anxiolytic and sedative-hypnotic dispensing in a developing country and a developed country, to determine whether further research about benzodiazepines is warranted. METHOD: A cross-national, cross-sectional retrospective drug utilisation study was conducted on benzodiazepines and z-drugs...
January 9, 2017: Current Drug Safety
https://www.readbyqxmd.com/read/28060888/the-association-between-gaba-modulators-and-clostridium-difficile-infection-a-matched-retrospective-case-control-study
#14
Jonathan Ström, Johan Tham, Fredrik Månsson, Jonas Ahl, Tor C Savidge, Sara M Dann, Fredrik Resman
OBJECTIVE: Recently, metabolomics studies have suggested that the neurotransmitter γ-amino butyric acid (GABA) may modulate C. difficile infection (CDI) pathogenesis. In the present study, we investigated the association between GABA-modulating pharmaceuticals and CDI development. METHODS: In July-December 2013, we performed a matched, retrospective case-control study in Skåne county, Sweden, to assess the association between the use of GABA-modulators (defined as regular use of at least one of the following: zolpidem, zopiclone, benzodiazepines, gabapentin, pregabalin or baclofen) and CDI...
2017: PloS One
https://www.readbyqxmd.com/read/28028585/effects-of-a-primary-care-intervention-to-improve-the-quality-of-zolpidem-prescriptions-in-elderly-patients
#15
Rocío López-Sepúlveda, María Ángeles García Lirola, Esther Espínola García, Salvadora Martín Sances, Sonia Anaya Ordóñez, José María Jurado Martínez, José Cabeza Barrera
PURPOSE: The objective of this study was to measure the impact of an intervention on the prescription habits of general practitioners (GPs) in order to improve the quality of zolpidem prescriptions in patients aged 75 or older. METHODS: A prospective multicentric non-randomized trial was performed in the Metropolitan Granada Primary Healthcare Area (Andalusian Public Healthcare Service, Spain), which serves a total population of approximately 675,000 inhabitants...
December 27, 2016: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28025361/drug-overdose-differing-risk-models-for-women-and-men-among-opioid-users-with-non-cancer-pain
#16
Yuanyuan Liang, Martin W Goros, Barbara J Turner
OBJECTIVE: To examine risk factors for drug overdose by sex reflecting differing patterns of opioid and other drug use. DESIGN: National privately insured cohort. SUBJECTS: 206,869 subjects filling ≥2 opioid prescriptions from January 2009 through July 2012. METHODS: Sex-specific prediction models for future drug overdose developed and validated using variables measured within 6 months after starting opioids: demographics, substance use, comorbidities, opioid dose, and psychoactive drugs...
December 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/27981241/high-throughput-screening-of-clinically-approved-drugs-that-prime-polyethylenimine-transfection-reveals-modulation-of-mitochondria-dysfunction-response-improves-gene-transfer-efficiencies
#17
Albert Nguyen, Jared Beyersdorf, Jean-Jack Riethoven, Angela K Pannier
Nonviral gene delivery methods are advantageous over viral vectors in terms of safety, cost, and flexibility in design and application, but suffer from lower gene transfer efficiency. In addition to modifications to nucleic acid design and nonviral carriers, new tools are sought to enhance transfection. Priming is the pharmacological modulation of transfection efficiency and transgene expression, and has demonstrated transfection increase in several compounds, for example, chloroquine and glucocorticoids. To develop a library of transfection priming compounds, a high-throughput screen was performed of the NIH Clinical Collection (NCC) to identify clinical compounds that prime polyethylenimine (PEI) transfection...
June 2016: Bioeng Transl Med
https://www.readbyqxmd.com/read/27974380/incorporation-of-zolpidem-into-hair-and-its-distribution-after-a-single-administration
#18
Noriaki Shima, Keiko Sasaki, Tooru Kamata, Shuntaro Matsuta, Misato Wada, Hidenao Kakehashi, Shihoko Nakano, Hiroe Kamata, Hiroshi Nishioka, Takako Sato, Hitoshi Tsuchihashi, Akihiro Miki, Munehiro Katagi
In order to obtain fundamental information on the drug incorporation into hair, time-course changes in drug distribution along single-strand hair were observed following a single oral administration of zolpidem (ZP), one of the most frequently-used hypnotics. Quantitative sectional hair analyses of 1-mm segments were performed for each single-strand hair using a validated liquid chromatography-tandem mass spectrometry procedure. ZP was detected in all specimens plucked at 10 and 24 hours after a single dose, and the distribution ranged over the whole hair root (4-5 mm in length)...
December 14, 2016: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/27901207/in-vitro-and-in-vivo-evaluation-of-nano-based-films-for-buccal-delivery-of-zolpidem
#19
Bandar Essa Al-Dhubiab
Insomnia is becoming increasingly prevalent in the world general population. Therapies used by patients include over-the-counter therapies, herbal and dietary supplements, and pharmacological or nonpharmacological treatments. Among these, zolpidem is a pharmacological treatment popularly used for insomnia. Zolpidem is well tolerated and especially efficacious for initiation of sleep, and therefore is effective for the treatment of sleep-onset insomnia. The purpose of the present study was to design and evaluate zolpidem nanoparticle-impregnated buccal films to prolong the duration of its action...
November 28, 2016: Brazilian Oral Research
https://www.readbyqxmd.com/read/27900070/potentially-inappropriate-medications-by-beers-criteria-in-older-outpatients-prevalence-and-risk-factors
#20
Yeon-Jung Lim, Ha-Yeon Kim, Jaekyung Choi, Ji Sun Lee, Ah-Leum Ahn, Eun-Jung Oh, Dong-Yung Cho, Hyuk-Jung Kweon
BACKGROUND: Prescription of inappropriate medicine to elderly patients is a major public health care concern. The Beers criteria have been commonly employed as a screening tool to identify the use of potentially inappropriate medications (PIMs). The present study investigated the prevalence of PIM use according to the Beers criteria as well as factors related to PIM use. METHODS: Data obtained from a retrospective survey included 25,810 outpatients aged ≥65 years from a university medical center in Seoul, Korea...
November 2016: Korean Journal of Family Medicine
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