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https://www.readbyqxmd.com/read/28735928/efficacy-and-safety-of-almorexant-in-adult-chronic-insomnia-a-randomized-placebo-controlled-trial-with-an-active-reference
#1
Jed Black, Giora Pillar, Jan Hedner, Olli Polo, Ouali Berkani, Sara Mangialaio, Abdel Hmissi, Gary Zammit, Goran Hajak
BACKGROUND AND OBJECTIVES: The orally active dual OX1R and OX2R antagonist, almorexant, targets the orexin system for the treatment of primary insomnia. This clinical trial assessed the effect of almorexant on sleep maintenance and other sleep endpoints, and its safety and tolerability in adults. PATIENTS AND METHODS: Prospective, randomized, double-blind, placebo-controlled, active referenced trial in male and female adults aged 18-64 years with chronic, primary insomnia...
August 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28734941/sleep-chronic-pain-and-opioid-risk-for-apnea
#2
REVIEW
Serguei Marshansky, Pierre Mayer, Dorrie Rizzo, Marc Baltzan, Ronald Denis, Gilles J Lavigne
Pain is an unwelcome sleep partner. Pain tends to erode sleep quality and alter the sleep restorative process in vulnerable patients. It can contribute to next-day sleepiness and fatigue, affecting cognitive function. Chronic pain and the use of opioid medications can also complicate the management of sleep disorders such as insomnia (difficulty falling and/or staying asleep) and sleep-disordered breathing (sleep apnea). Sleep problems can be related to various types of pain, including sleep headache (hypnic headache, cluster headache, migraine) and morning headache (transient tension type secondary to sleep apnea or to sleep bruxism or tooth grinding) as well as periodic limb movements (leg and arm dysesthesia with pain)...
July 19, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28716996/long-term-benzodiazepine-and-z-drugs-use-in-the-uk-a-survey-of-general-practice
#3
James Davies, Todd C Rae, Luke Montagu
BACKGROUND: Current British National Formulary (BNF) guidelines state that benzodiazepines and zolpidem, zopiclone, and zaleplon, commonly known as Z-drugs (BZD), be prescribed for no more than 4 weeks, although anecdotal data suggest that many patients are prescribed BZDs for much longer. As there are no recent, evidence-based estimates of long-term (>12 months) BZD use in the UK, the scale of this potential problem is unknown. AIM: To produce the first reliable, evidence-based estimate of long-term BZD use in the UK...
July 17, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28671376/insomnia-pharmacologic-therapy
#4
REVIEW
Eric Matheson, Barry L Hainer
Insomnia accounts for more than 5.5 million visits to family physicians each year. Although behavioral interventions are the mainstay of treatment, pharmacologic therapy may be necessary for some patients. Understanding the risks and benefits of insomnia medications is critical. Controlled-release melatonin and doxepin are recommended as first-line agents in older adults; the so-called z-drugs (zolpidem, eszopiclone, and zaleplon) should be reserved for use if the first-line agents are ineffective. For the general population with difficulty falling asleep, controlled-release melatonin and the z-drugs can be considered...
July 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28669021/new-occasional-and-frequent-use-of-zolpidem-or-zopiclone-alone-and-in-combination-and-the-risk-of-injurious-road-traffic-crashes-in-older-adult-drivers-a-population-based-case-control-and-case-crossover-study
#5
Alicia Nevriana, Jette Möller, Lucie Laflamme, Joel Monárrez-Espino
BACKGROUND: Previous studies on the effect of zolpidem or zopiclone use on the risk of road traffic crashes (RTCs) have shown mixed results. OBJECTIVE: Our objective was to determine the association between zolpidem or zopiclone use (as separate drugs or combined) and the occurrence of injurious RTCs among older adult drivers. METHODS: This was a population-based matched case-control and case-crossover study based on secondary data linked together from Swedish national registers...
August 2017: CNS Drugs
https://www.readbyqxmd.com/read/28667742/gingival-bleeding-a-possible-serious-adverse-drug-reaction-an-observational-study-in-the-french-pharmacovigilance-database
#6
Emmanuelle Bondon-Guitton, Thibaut Mourgues, Vanessa Rousseau, Sarah Cousty, Judith Cottin, Guillaume Drablier, Joëlle Micallef, Jean-Louis Montastruc
INTRODUCTION: Antithrombotic drugs are known to increase the risk of gingival bleeding because they affect coagulation. However, other drugs could also be involved in gingival bleeding. AIM: We performed a pharmacoepidemiological study to identify the drugs most frequently "suspected" in the occurrence of gingival bleeding. MATERIAL AND METHODS: We selected reports of "gingival bleeding" from 1 January 1985 to 30 September 2014 in the French PharmacoVigilance Database...
July 1, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28655027/zolpidem-for-the-treatment-of-neurologic-disorders-a-systematic-review
#7
Martin N Bomalaski, Edward S Claflin, Whitney Townsend, Mark D Peterson
Importance: Given its selective action on the ω1 subtype of the γ-aminobutyric acid A receptor, zolpidem tartrate presents a potential treatment mechanism for other neurologic disorders. Objective: To synthesize studies that used zolpidem to treat neurologic disorders. Evidence Review: Eligibility criteria included any published English-language article that examined the use of zolpidem for noninsomnia neurologic disorders in humans for all dates up to March 20, 2015...
June 26, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28649875/potential-benefits-of-zolpidem-in-disorders-of-consciousness
#8
Afsaneh Noormandi, Maryam Shahrokhi, Hossein Khalili
It has been suggested that zolpidem may arouse patients with decreased level of consciousness. Zolpidem may partially or even completely reverse abnormal cell metabolism following brain damage. In this article, available evidences regarding effects of zolpidem on disorders of consciousness were reviewed. Areas covered: A literature review was conducted using PubMed, Scopus, Medline, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews and Google Scholar as online databases...
July 10, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28649864/the-french-addictovigilance-network-clinical-assessment-z-drugs-true-false-twins
#9
Morgane Rousselet, Fanny Feuillet, Marie Gerardin, Pascale Jolliet, Jean-Benoit Hardouin, Caroline Victorri-Vigneau
INTRODUCTION: In France, an addictovigilance network is responsible for evaluating drug dependence, by drawing on pharmacoepidemiological studies, clinical studies and by assessing healthcare professionals' reports on problematic consumption. METHODS: The aim of this study was to determine whether zolpidem and zopiclone have different dependence profiles, based on healthcare professionals' reports, and to identify various consumer dependence profiles among zolpidem users and among zopiclone users...
June 28, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28638826/anxiolytics-sedatives-and-hypnotics-prescribed-by-dentists-in-brazil-in-2010
#10
Patrícia Azevedo Lino, Maria Auxiliadora Parreiras Martins, Maria Elisa de Souza E Silva, Mauro Henrique Nogueira Guimarães de Abreu
OBJECTIVE: To describe dental prescriptions for anxiolytics, sedatives, and hypnotics for Brazilian outpatients in 2010. METHODS: A cross-sectional study was conducted using data on the use of anxiolytics, sedatives, and hypnotics from the Brazilian Health Surveillance Agency, Brazil, 2010. For each prescription, prescribed drugs and the prescribed amount were identified. Prescribed medications were classified according to Anatomical Therapeutic Chemical code. We calculated the number of Defined Daily Doses (DDD) for anxiolytics, sedatives, and hypnotics by code, their mean DDD, and DDD per inhabitant per year...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28593713/effectiveness-of-sleep-self-management-group-intervention-in-chinese-patients-with-insomnia-disorder
#11
HongJing Mao, JianLi Wu, You Xu, Yi Liu, XiangDong Tang
PURPOSE: The purpose of this study was to explore the effectiveness of sleep self-management group intervention for insomnia disorder. DESIGN AND METHODS: One hundred four patients with insomnia disorder were recruited from The Seventh Hospital of Hangzhou, from February to November 2015. After completing the Pittsburgh Sleep Quality Index (PSQI) and Sleep Diary and Beliefs and Attitudes about Sleep Scale (DBAS), they were randomly assigned into the intervention group (n = 52) and the control group (n = 52)...
June 7, 2017: Perspectives in Psychiatric Care
https://www.readbyqxmd.com/read/28575467/arousability-and-fall-risk-during-forced-awakenings-from-nocturnal-sleep-among-healthy-males-following-administration-of-zolpidem-10-mg-and-doxepin-6-mg-a-randomized-placebo-controlled-four-way-crossover-trial
#12
Christopher L Drake, Heith Durrence, Philip Cheng, Thomas Roth, Vivek Pillai, Edward L Peterson, Meeta Singh, Kieulinh Michelle Tran
Study Objectives: To examine and compare the arousability threshold and fall risk upon awakening of doxepin (6 mg) versus zolpidem (10 mg). Methods: A total of 52 healthy adult males were included in a double-blind, placebo-controlled, 4-way crossover study. The experimental procedure included four nights with polysomnography in the lab (zolpidem, doxepin, and their respective placebo conditions). Arousability was measured using an auditory awakening threshold delivered at the peak-plasma concentration for the active hypnotics and at matched times for the respective placebo conditions...
June 1, 2017: Sleep
https://www.readbyqxmd.com/read/28534652/a-review-of-the-evidence-of-zolpidem-efficacy-in-neurological-disability-after-brain-damage-due-to-stroke-trauma-and-hypoxia-a-justification-of-further-clinical-trials
#13
J A Sutton, R P Clauss
During 15 years, 23 clinical reports and 6 studies have demonstrated associations between sub-sedative doses of zolpidem and recoveries from brain damage due to strokes, trauma and hypoxia. Clinical findings include unexpected awakenings from vegetative states and regressions of stroke symptoms after dosing that disappear during elimination and reappear on repeat dosing. Initially single-photon emission computed tomography scans showed improved perfusion within, around and distant from infarctions. Then positron emission tomography scans and electroencephalography detected renewed metabolic and neuronal activity...
2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28515934/zolpidem-prescribing-practices-before-and-after-food-and-drug-administration-required-product-labeling-changes
#14
Jessica L Norman, Danielle R Fixen, Joseph J Saseen, Laura M Saba, Sunny A Linnebur
BACKGROUND: Women have higher morning serum zolpidem concentrations than men after taking an evening dose, potentially leading to increased risk of harm. On 19 April 2013, the United States Food and Drug Administration required labeling changes for zolpidem, recommending an initial dose of no greater than 5 mg (immediate release) or 6.25 mg (controlled release) per night in women. OBJECTIVES: The primary objective of this study was to compare prescribing practices before and after the 2013 zolpidem labeling change...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28471831/response-to-improvement-of-sleep-architecture-parameters-in-cirrhotic-patients-with-recurrent-hepatic-encephalopathy-with-the-use-of-rifaximin-hepatic-encephalopathy-in-association-with-zolpidem
#15
Ofir N Nevo, Allen D Brinker, Ida-Lina Diak, Cindy M Kortepeter
No abstract text is available yet for this article.
September 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28470069/visible-light-induced-regioselective-cyanomethylation-of-imidazopyridines-and-its-application-in-drug-synthesis
#16
Qing Chang, Zhengyi Liu, Ping Liu, Lu Yu, Peipei Sun
3-Cyanomethylated imidazopyridines were synthesized via a visible light-promoted reaction of imidazopyridines with bromoacetonitrile or iodoacetonitrile catalyzed by fac-Ir(ppy)3 under mild conditions. For the substrates with various substituents on benzene or pyridine ring, the reaction proceeded smoothly to give the corresponding products in moderate to good yields. The synthetic utility of this visible-light-induced reaction has been illustrated in the efficient synthesis of zolpidem and alpidem.
May 9, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28454597/time-trends-in-the-family-physician-management-of-insomnia-the-australian-experience-2000-2015
#17
Christopher B Miller, Lisa Valenti, Christopher M Harrison, Delwyn J Bartlett, Nick Glozier, Nathan E Cross, Ronald R Grunstein, Helena C Britt, Nathaniel S Marshall
STUDY OBJECTIVES: To evaluate changes in rates of family physician (FP) management of insomnia in Australia from 2000-2015. METHODS: The Bettering the Evaluation And Care of Health (BEACH) program is a nationally representative cross-sectional survey of 1,000 newly randomly sampled family physicians' activity in Australia per year, who each record details of 100 consecutive patient encounters. This provided records of approximately 100,000 encounters each year. We identified all encounters with patients older than 15 years where insomnia or difficulty sleeping was managed and assessed trends in these encounters from 2000-2015...
June 15, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28451875/prevalence-of-gabapentin-abuse-comparison-with-agents-with-known-abuse-potential-in-a-commercially-insured-us-population
#18
Alyssa M Peckham, Kathleen A Fairman, David A Sclar
BACKGROUND: Despite international calls to make gabapentin a controlled substance, studies of gabapentin use/abuse patterns are limited to small/high-risk samples and adverse event reports. OBJECTIVE: The aim of this study was to conduct a systematic assessment of the abuse potential/prevalence of gabapentin in a large sample. DATA SOURCE: Truven Health MarketScan(®) Commercial Claims and Encounters database, years 2013-2015. ELIGIBILITY CRITERIA: Patients with two or more claims for one or more abusable drugs and ≥12 months' continuous enrollment were sampled for Lorenz curve analysis...
August 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28449404/changes-in-prescribing-and-healthcare-resource-utilization-after-fda-drug-safety-communications-involving-zolpidem-containing-medications
#19
Aaron S Kesselheim, Macarius Donneyong, Gerald J Dal Pan, Esther H Zhou, Jerry Avorn, Sebastian Schneeweiss, John D Seeger
PURPOSE: Products containing the sedative/hypnotic zolpidem were subject to Drug Safety Communications (DSCs) in January and May 2013 describing the risk of next-morning impairment and recommending lower starting doses particularly for women. This study aimed to assess whether zolpidem DSCs were associated with prescribing-pattern changes between January 2011 and December 2013. METHODS: We assessed overall dispensings of zolpidem-containing products between January 2011 and December 2013 by conducting a time-series analysis...
April 27, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28445059/iron-catalyzed-dehydrogenative-sp-3-sp-2-coupling-via-direct-oxidative-c-h-activation-of-acetonitrile
#20
Huimin Su, Luyao Wang, Honghua Rao, Hao Xu
An iron-catalyzed dehydrogenative sp(3)-sp(2) coupling of acetonitrile and 2-arylimidazo[1,2-a]pyridine has been realized, which can serve as a novel approach toward heteroarylacetonitriles. The merit of this strategy is illustrated by the breadth of functional groups tolerated in the transformation and the fast access to pharmaceuticals (such as zolpidem) directly from the heteroarylacetonitriles.
May 5, 2017: Organic Letters
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