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https://www.readbyqxmd.com/read/27527654/expression-of-mismatch-repair-proteins-in-early-and-advanced-gastric-cancer-in-poland
#1
Katarzyna Karpińska-Kaczmarczyk, Magdalena Lewandowska, Małgorzata Ławniczak, Andrzej Białek, Elżbieta Urasińska
BACKGROUND Mutations in DNA of mismatch repair (MMR) genes result in failure to repair errors that occur during DNA replication in microsatellites, resulting in accumulation of frameshift mutations in these genes and leading to DNA mismatch replication errors and microsatellite instability. Gastric cancers (GCs) with high MSI (MSI-H) are a well-defined subset of carcinomas showing distinctive clinicopathological features. In this study we investigated the rate of MSI and the correlation between MSI status and clinicopathological features of GC...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27409521/breath-analysis-based-on-surface-enhanced-raman-scattering-sensors-distinguishes-early-and-advanced-gastric-cancer-patients-from-healthy-persons
#2
Yunsheng Chen, Yixia Zhang, Fei Pan, Jie Liu, Kan Wang, Chunlei Zhang, Shangli Cheng, Lungen Lu, Wei Zhang, Zheng Zhang, Xiao Zhi, Qian Zhang, Gabriel Alfranca, Jesús M de la Fuente, Di Chen, Daxiang Cui
Fourteen volatile organic compound (VOC) biomarkers in the breath have been identified to distinguish early gastric cancer (EGC) and advanced gastric cancer (AGC) patients from healthy persons by gas chromatography-mass spectrometry coupled with solid phase microextraction (SPME). Then, a breath analysis approach based on a surface-enhanced Raman scattering (SERS) sensor was developed to detect these biomarkers. Utilizing hydrazine vapor adsorbed in graphene oxide (GO) film, the clean SERS sensor is facilely prepared by in situ formation of gold nanoparticles (AuNPs) on reduced graphene oxide (RGO) without any organic stabilizer...
September 27, 2016: ACS Nano
https://www.readbyqxmd.com/read/27336885/comparison-of-laparoscopy-assisted-and-open-radical-gastrectomy-for-advanced-gastric-cancer-a-retrospective-study-in-a-single-minimally-invasive-surgery-center
#3
Yingxue Hao, Peiwu Yu, Feng Qian, Yongliang Zhao, Yan Shi, Bo Tang, Dongzhu Zeng, Chao Zhang
Laparoscopy-assisted gastrectomy (LAG) has gained international acceptance for the treatment of early gastric cancer (EGC). However, the use of laparoscopic surgery in the management of advanced gastric cancer (AGC) has not attained widespread acceptance. This retrospective large-scale patient study in a single center for minimally invasive surgery assessed the feasibility and safety of LAG for T2 and T3 stage AGC. A total of 628 patients underwent LAG and 579 patients underwent open gastrectomy (OG) from Jan 2004 to Dec 2011...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27312513/genome-wide-analysis-of-dna-copy-number-alterations-in-early-and-advanced-gastric-cancers
#4
Noriyuki Arakawa, Tamotsu Sugai, Wataru Habano, Makoto Eizuka, Ryo Sugimoto, Risaburo Akasaka, Yosuke Toya, Eiichiro Yamamoto, Keisuke Koeda, Akira Sasaki, Takayuki Matsumoto, Hiromu Suzuki
To better understand progressive changes in gastric cancer (GC), early and advanced GCs (EGC and AGC, respectively) were examined for copy number alterations (CNAs). A crypt isolation method was used to isolate DNA from tumors and normal glands in 20 AGCs, and fresh tumor samples were obtained from 45 EGCs. We assessed CNAs for differentiated-type GCs using an Infinium HumanCytoSNP-12v2.1 BeadChip in EGCs and AGCs. The most frequent aberrations in EGC were gains at 8q23.3 (42.2%) and 8q23.2 (40%), and loss of heterozygosity (LOH) at 3p14...
June 17, 2016: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/26973384/gastric-cancer-current-status-of-lymph-node-dissection
#5
REVIEW
Maurizio Degiuli, Giovanni De Manzoni, Alberto Di Leo, Domenico D'Ugo, Erica Galasso, Daniele Marrelli, Roberto Petrioli, Karol Polom, Franco Roviello, Francesco Santullo, Mario Morino
D2 procedure has been accepted in Far East as the standard treatment for both early (EGC) and advanced gastric cancer (AGC) for many decades. Recently EGC has been successfully treated with endoscopy by endoscopic mucosal resection or endoscopic submucosal dissection, when restricted or extended Gotoda's criteria can be applied and D1+ surgery is offered only to patients not fitted for less invasive treatment. Furthermore, two randomised controlled trials (RCTs) have been demonstrating the non inferiority of minimally invasive technique as compared to standard open surgery for the treatment of early cases and recently the feasibility of adequate D1+ dissection has been demonstrated also for the robot assisted technique...
March 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26694184/diagnostic-group-classifications-of-gastric-neoplasms-by-endoscopic-resection-criteria-before-and-after-treatment-real-world-experience
#6
Jun Hee Lee, Yang Won Min, Jun Haeng Lee, Eun Ran Kim, Hyuk Lee, Byung-Hoon Min, Jae J Kim, Kee-Taek Jang, Kyoung-Mee Kim, Cheol Keun Park
BACKGROUND AND STUDY AIMS: There are often discrepancies between the pretreatment evaluation of gastric neoplasms by endoscopy with biopsy and the final diagnosis of resected specimen in terms of pathology and depth of invasion. We evaluated the spectrum of discrepancies between pretreatment and posttreatment diagnosis which may deliver significant differences on clinical practice. PATIENTS AND METHODS: A total of 2041 patients with gastric dysplasia or cancer who underwent curative endoscopic resections or surgeries in 2012 were enrolled...
September 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/26494937/her2-status-in-premalignant-early-and-advanced-neoplastic-lesions-of-the-stomach
#7
REVIEW
A Ieni, V Barresi, L Rigoli, R A Caruso, G Tuccari
OBJECTIVES: HER2 expression in gastric cancer (GC) has received attention as a potential target for therapy with Trastuzumab. We reviewed the current knowledge on HER2 status in premalignant gastric lesions and in early (EGC) and advanced (AGC) GC to discuss the possible pathogenetic and prognostic roles of HER2 overexpression in GC. RESULTS: HER2 overexpression was documented in gastric low-grade (LG) and high-grade intraepithelial neoplasia (HG-IEN), with higher frequency in gastric type dysplasia...
2015: Disease Markers
https://www.readbyqxmd.com/read/26487206/discordant-findings-between-preoperative-endoscopy-and-postoperative-pathology-as-an-independent-prognostic-factor-in-gastric-cancer-patients
#8
Ju-Hee Lee, Kang Nyeong Lee, Hyun-Il Kim, Min Gyu Kim, Tae Kyung Ha, Sung Joon Kwon
BACKGROUND: Endoscopically diagnosed early gastric cancers (EGCs) are sometimes revealed to be advanced gastric cancers (AGCs) on pathologic examination of the resected specimen, and also endoscopically diagnosed AGCs are often determined to be EGCs. This study was designed to determine the impact on prognosis of the discordant finding between preoperative endoscopy and postoperative pathology in gastric cancer patients. METHODS: Patients with gastric cancer stages pT1a-T4a who underwent curative gastrectomy between 2004 and 2010 were included in the study...
July 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/26242583/differentiation-of-early-gastric-cancer-with-ulceration-and-resectable-advanced-gastric-cancer-using-multiphasic-dynamic-multidetector-ct
#9
Daisuke Tsurumaru, Mitsutoshi Miyasaka, Yusuke Nishimuta, Yoshiki Asayama, Akihiro Nishie, Satoshi Kawanami, Eiji Oki, Minako Hirahashi, Hiroshi Honda
OBJECTIVES: Early gastric cancer with ulceration (EGC-U) mimics advanced gastric cancer (AGC), as EGC-Us and ACGs often have similar endoscopic appearance to ulceration. The purpose of this retrospective study was to determine whether multiphasic dynamic multidetector CT (MDCT) can help differentiate EGC-Us from AGCs. METHODS: Patients with EGC-Us with ulcer stages Ul-III or IV and AGCs with tumour stages T2 to T4a were enrolled. MDCT images were obtained 40 s (arterial phase), 70 s (portal phase) and 240 s (delayed phase) after injection of non-ionic contrast material...
May 2016: European Radiology
https://www.readbyqxmd.com/read/26217087/clinical-features-of-second-primary-cancers-arising-in-early-gastric-cancer-patients-after-endoscopic-resection
#10
Jung-Wook Kim, Jae-Young Jang, Young Woon Chang, Yong Ho Kim
AIM: To investigate the incidence and distribution of second primary cancers (SPCs) in early gastric cancer (EGC) patients who underwent endoscopic resection (ER), compared to advanced gastric cancer (AGC) patients who underwent surgery. METHODS: The medical records of 1021 gastric cancer (GC) patients were retrospectively reviewed from January 2006 to December 2010. The characteristics and incidence of SPCs were investigated in those with EGC that underwent curative ER (the EGC group) and those with AGC who underwent curative surgical resection (the AGC group)...
July 21, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/25779358/cd44-variant-9-serves-as-a-poor-prognostic-marker-in-early-gastric-cancer-but-not-in-advanced-gastric-cancer
#11
Se-Il Go, Gyung Hyuck Ko, Won Sup Lee, Rock Bum Kim, Jeong-Hee Lee, Sang-Ho Jeong, Young-Joon Lee, Soon Chan Hong, Woo Song Ha
PURPOSE: The present study is to investigate the significance of CD44 variant 9 (CD44v9) expression as a biomarker in primary gastric cancer. MATERIALS AND METHODS: With various gastric tissues, we performed immunohistochemical staining for CD44v9. RESULTS: The positive expression rates for CD44v9 in tumor, including adenoma, early gastric cancer (EGC), and advanced gastric cancer (AGC), were higher than those in non-tumor tissues (p=0.003)...
January 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/25717241/clinical-significance-and-usefulness-of-soluble-heparin-binding-epidermal-growth-factor-in-gastric-cancer
#12
Hye Won Chung, Hoon Young Kong, Jong-Baeck Lim
AIM: To evaluate the clinical usefulness of soluble heparin-binding epidermal growth factor (sHB-EGF) as a serum biomarker for gastric cancer (GC). METHODS: Serum sHB-EGF levels were measured by a commercially available human HB-EGF ELISA Kit and compared among 60 normal controls, 30 high-risk patients, 37 early gastric cancer (EGC), and 30 advanced gastric cancer (AGC) through ANOVA test. Correlations between serum sHB-EGF and clinicopathological features of GC were analyzed through Spearman's correlation...
February 21, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/25689618/serum-ena78-cxcl5-sdf-1-cxcl12-and-their-combinations-as-potential-biomarkers-for-prediction-of-the-presence-and-distant-metastasis-of-primary-gastric-cancer
#13
Jong-Baeck Lim, Hye Won Chung
BACKGROUND: Chemokines play important roles in cancer development and progression. Epithelial-derived neutrophil-activating peptide-78 (ENA78/CXCL5) and stromal cell-derived factor (SDF-1/CXCL12) supposedly contribute to gastric cancer (GC) development and progression. This study aims to evaluate serum levels of ENA78/CXCL5 and SDF-1/CXCL12 along the GC carcinogenesis, and analyze their clinical significance, and diagnostic potentials through human serum samples. METHODS: A total of 300 subjects were enrolled in this study...
May 2015: Cytokine
https://www.readbyqxmd.com/read/25642244/prevalence-of-precancerous-conditions-and-gastric-cancer-based-upon-the-national-cancer-screening-program-in-korea-for-7-years-single-center-experience
#14
Ji Hyuk Kang, Yun Jeong Lim, Jung Hyun Kang, Jae Nam Yang, Seung Min Shin, Jae Hyeuk Choi, Jin Ho Lee
Aims. Gastric cancer is the second most prevalent cancer and the third leading cause of cancer-related deaths in Korea. The National Cancer Screening Program (NCSP) has implemented esophagogastroduodenoscopy (EGD) biennially for all Koreans starting in their 40s. This study was conducted to estimate the clinical relevance of NCSP through identifying the prevalence of gastric disease, including cancer. Materials and Methods. Data from 40,821 subjects who received the screening EGD in the single center for 7 years were retrospectively investigated...
2015: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/25154912/clinical-significance-of-serum-thymus-and-activation-regulated-chemokine-in-gastric-cancer-potential-as-a-serum-biomarker
#15
Jong-Baeck Lim, Do-Kyun Kim, Hye Won Chung
Thymus and activation-regulated chemokine (TARC) can stimulate cancer cell proliferation and migration. The present study evaluated the clinical significance of serum TARC in gastric cancer (GC). We measured serum TARC, macrophage-derived chemokine, monocyte chemotactic protein-1 and stem cell factor (SCF) levels using a chemiluminescent immunoassay along the GC carcinogenesis (normal, high-risk, early GC [EGC] and advanced GC [AGC]) in both training (N = 25 per group) and independent validation datasets (90 normal, 30 high-risk, 50 EGC and 50 AGC)...
October 2014: Cancer Science
https://www.readbyqxmd.com/read/25042771/the-mutational-burdens-and-evolutionary-ages-of-early-gastric-cancers-are-comparable-to-those-of-advanced-gastric-cancers
#16
Tae-Min Kim, Seung-Hyun Jung, Min Sung Kim, In-Pyo Baek, Sung-Won Park, Sung Hak Lee, Han Hong Lee, Sung Soo Kim, Yeun-Jun Chung, Sug Hyung Lee
Early gastric cancers (EGCs) precede advanced gastric cancers (AGCs), with a favourable prognosis compared to AGC. To understand the progression mechanism of EGC to AGC, it is required to disclose EGC and AGC genomes in mutational and evolutionary perspectives. We performed whole-exome sequencing and copy number profiling of nine microsatellite (MS)-unstable (MSI-H) (five EGCs and four AGCs) and eight MS-stable (MSS) gastric cancers (four EGCs and four AGCs). In the cancers, we observed well-known driver mutations (TP53, APC, PIK3CA, ARID1A, and KRAS) that were enriched in cancer-related pathways, including chromatin remodelling and tyrosine kinase activity...
November 2014: Journal of Pathology
https://www.readbyqxmd.com/read/24569072/the-role-of-leptin-in-gastric-cancer-clinicopathologic-features-and-molecular-mechanisms
#17
Kang Nyeong Lee, Ho Soon Choi, Sun Young Yang, Hyun Ki Park, Young Yiul Lee, Oh Young Lee, Byung Chul Yoon, Joon Soo Hahm, Seung Sam Paik
Obesity is associated with certain types of cancer, including gastric cancer. However, it is still unclear whether obesity-related cytokine, leptin, is implicated in gastric cancer. Therefore, we aimed to investigate the role of leptin in gastric cancer. The expression of leptin and its receptor, Ob-R, was assessed by immunohistochemical staining and was compared in patients with gastric adenoma (n=38), early gastric cancer (EGC) (n=38), and advanced gastric cancer (AGC) (n=38), as a function of their clinicopathological characteristics...
April 18, 2014: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/24376576/exome-sequencing-identifies-early-gastric-carcinoma-as-an-early-stage-of-advanced-gastric-cancer
#18
Guhyun Kang, Woo Cheol Hwang, In-Gu Do, Kai Wang, So Young Kang, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Won Ki Kang, Jiryeon Jang, Min-Gew Choi, Jun Ho Lee, Tae Sung Sohn, Jae Moon Bae, Sung Kim, Min Ji Kim, Seonwoo Kim, Cheol Keun Park, Kyoung-Mee Kim
Gastric carcinoma is one of the major causes of cancer-related mortality worldwide. Early detection and treatment leads to an excellent prognosis in patients with early gastric cancer (EGC), whereas the prognosis of patients with advanced gastric cancer (AGC) remains poor. It is unclear whether EGCs and AGCs are distinct entities or whether EGCs are the beginning stages of AGCs. We performed whole exome sequencing of four samples from patients with EGC and compared the results with those from AGCs. In both EGCs and AGCs, a total of 268 genes were commonly mutated and independent mutations were additionally found in EGCs (516 genes) and AGCs (3104 genes)...
2013: PloS One
https://www.readbyqxmd.com/read/24348842/requirement-for-a-standardised-definition-of-advanced-gastric-cancer
#19
Angelo DE Sol, Stefano Trastulli, Veronica Grassi, Alessia Corsi, Ivan Barillaro, Andrea Boccolini, Micol Sole DI Patrizi, Giorgio DI Rocco, Alberto Santoro, Roberto Cirocchi, Carlo Boselli, Adriano Redler, Giuseppe Noya, Seong-Ho Kong
Each year, ~988,000 new cases of stomach cancer are reported worldwide. Uniformity for the definition of advanced gastric cancer (AGC) is required to ensure the improved management of patients. Various classifications do actually exist for gastric cancer, but the classification determined by lesion depth is extremely important, as it has been shown to correlate with patient prognosis; for example, early gastric cancer (EGC) has a favourable prognosis when compared with AGC. In the literature, the definition of EGC is clear, however, there is heterogeneity in the definition of AGC...
January 2014: Oncology Letters
https://www.readbyqxmd.com/read/24170961/clinicopathologic-characteristics-and-prognosis-of-advanced-gastric-cancer-simulating-early-gastric-cancer
#20
Hiroaki Saito, Kozo Miyatani, Seigo Takaya, Tomoyuki Matsunaga, Yoji Fukumoto, Tomohiro Osaki, Toshiro Wakatsuki, Masahide Ikeguchi
BACKGROUND: Although the clinicopathologic features and prognosis of Borrmann type advanced gastric cancer has been well characterized, those of advanced gastric cancer simulating early gastric cancer (AGC simulating EGC) still remains unclear. METHODS: We reviewed 1985 gastric cancer patients who had undergone gastrectomy at our hospital to determine the clinicopathologic characteristics, susceptible sites for lymph node metastasis, and prognosis of AGC simulating EGC in comparison with Borrmann type advanced gastric cancer...
September 2013: Yonago Acta Medica
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