Khushali Parikh, Brooke R Shepley, Michael M Tymko, Jamie G Hijmans, Ryan L Hoiland, Christopher A Desouza, Mypinder S Sekhon, Philip N Ainslie, Anthony R Bain
Passive hyperthermia causes cerebral hypoperfusion primarily from heat-induced respiratory alkalosis. However, despite the cerebral hypoperfusion, it is possible that the mild alkalosis might help to attenuate cerebral inflammation. In this study, the cerebral exchange of extracellular vesicles (microvesicles), which are known to elicit pro-inflammatory responses when released in conditions of stress, were examined in hyperthermia with and without respiratory alkalosis. Ten healthy male adults were heated passively, using a warm water-perfused suit, up to core temperature + 2°C...
November 17, 2023: Journal of Physiology