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https://www.readbyqxmd.com/read/29923857/female-sex-is-associated-with-poor-health-related-quality-of-life-in-children-at-12-months-post-hematopoietic-cell-transplantation
#1
Neel S Bhatt, Ruta Brazauskas, Heather R Tecca, Jenny Vogel, Deborah Mattila, Stephanie J Lee, Mary M Horowitz, J Douglas Rizzo, Bronwen E Shaw
To study the factors associated with poorer health-related quality of life at 1-year post-allogeneic hematopoietic cell transplantation (alloHCT), a secondary analysis of a prospective feasibility study was performed. Pediatric Quality of Life Inventory questionnaires were collected in 76 children undergoing alloHCT at baseline (within 30 d before transplantation), day 100, 6 months, and 12 months posttransplantation. The global score improved post-HCT (baseline: 67.1, 12 mo: 76.6). Females (odds ratio, 6...
June 19, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29923602/mechanical-oscillations-superimposed-on-the-pelvic-floor-muscles-during-kegel-exercises-reduce-urine-leakage-in-women-suffering-from-stress-urinary-incontinence-a-prospective-cohort-study-with-a-two-year-follow-up
#2
Ingard Nilsen, Guillermo Rebolledo, Ganesh Acharya, Gunnar Leivseth
INTRODUCTION: New methods of conservative treatment of female stress urinary continence are needed. We investigated whether superimposed vibration mechanosignals during Kegel exercises could reduce the amount of urinary leakage after four and six weeks of training. MATERIAL AND METHODS: Sixty women with stress urinary continence were included in this prospective cohort study. Vibration mechanosignals were superimposed during Kegel exercises using an intravaginal device...
June 20, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29923104/rationale-and-design-of-the-registry-of-fast-myocardial-perfusion-imaging-with-next-generation-spect-refine-spect
#3
Piotr J Slomka, Julian Betancur, Joanna X Liang, Yuka Otaki, Lien-Hsin Hu, Tali Sharir, Sharmila Dorbala, Marcelo Di Carli, Mathews B Fish, Terrence D Ruddy, Timothy M Bateman, Andrew J Einstein, Philipp A Kaufmann, Edward J Miller, Albert J Sinusas, Peyman N Azadani, Heidi Gransar, Balaji K Tamarappoo, Damini Dey, Daniel S Berman, Guido Germano
BACKGROUND: We aim to establish a multicenter registry collecting clinical, imaging, and follow-up data for patients who undergo myocardial perfusion imaging (MPI) with the latest generation SPECT scanners. METHODS: REFINE SPECT (REgistry of Fast Myocardial Perfusion Imaging with NExt generation SPECT) uses a collaborative design with multicenter contribution of clinical data and images into a comprehensive clinical-imaging database. All images are processed by quantitative software...
June 19, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29922497/long-term-functional-results-of-a-wrist-exercise-program-for-patients-with-palmar-midcarpal-instability
#4
M A M Mulders, G S I Sulkers, A J Videler, S D Strackee, M J C Smeulders
Background  Patients with palmar midcarpal instability have symptoms of pain, combined with clinical signs of abnormal mobility on stressing the joint, an unpredictable blockade feeling, and a noticeable clunk, in the absence of an underlying trauma. No data are available on the effect of conservative treatment for these patients. Purpose  The purpose of this study was to evaluate the effect and the long-term functional outcomes of a wrist exercise program in patients with palmar midcarpal instability. Patients and Methods  All patients diagnosed with palmar midcarpal instability between 2005 and 2011 were included...
July 2018: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/29922131/adult-hippocampal-neurogenesis-regulation-and-possible-functional-and-clinical-correlates
#5
REVIEW
Pedro Baptista, José P Andrade
The formation of new neurons in the adult central nervous system (CNS) has been recognized as one of the major findings in neuroanatomical research. The hippocampal formation (HF), one of the main targets of these investigations, holds a neurogenic niche widely recognized among several mammalian species and whose existence in the human brain has sparked controversy and extensive debate. Many cellular features from this region emphasize that hippocampal neurogenesis suffers changes with normal aging and, among regulatory factors, physical exercise and chronic stress provoke opposite effects on cell proliferation, maturation and survival...
2018: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/29921524/impact-loading-history-modulates-hip-fracture-load-and-location-a-finite-element-simulation-study-of-the-proximal-femur-in-female-athletes
#6
Shinya Abe, Nathaniel Narra, Riku Nikander, Jari Hyttinen, Reijo Kouhia, Harri Sievänen
Sideways falls impose high stress on the thin superolateral cortical bone of the femoral neck, the region regarded as a fracture-prone region of the hip. Exercise training is a natural mode of mechanical loading to make bone more robust. Exercise-induced adaptation of cortical bone along the femoral neck has been previously demonstrated. However, it is unknown whether this adaption modulates hip fracture behavior. The purpose of this study was to investigate the influence of specific exercise loading history on fall-induced hip fracture behavior by estimating fracture load and location with proximal femur finite element (FE) models created from magnetic resonance images (MRI) of 111 women with distinct exercise histories: 91 athletes (aged 24...
June 8, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29920702/false-positive-stress-testing-does-endothelial-vascular-dysfunction-contribute-to-st-segment-depression-in-women-a-pilot-study
#7
Shilpa Sharma, Puja K Mehta, Reza Arsanjani, Tara Sedlak, Zachary Hobel, Chrisandra Shufelt, Erika Jones, Paul Kligfield, David Mortara, Michael Laks, Marcio Diniz, C Noel Bairey Merz
BACKGROUND: The utility of exercise-induced ST-segment depression for diagnosing ischemic heart disease (IHD) in women is unclear. HYPOTHESIS: Based on evidence that IHD pathophysiology in women involves coronary vascular dysfunction, we hypothesized that coronary vascular dysfunction contributes to exercise electrocardiography (Ex-ECG) ST-depression in the absence of obstructive CAD, so-called "false positive" results. We tested our hypothesis in a pilot study evaluating the relationship between peripheral vascular endothelial function and Ex-ECG...
June 19, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29916025/short-term-weight-loss-reverses-obesity-induced-microvascular-endothelial-dysfunction
#8
Tamas Csipo, Gabor A Fulop, Agnes Lipecz, Stefano Tarantini, Tamas Kiss, Priya Balasubramanian, Anna Csiszar, Zoltan Ungvari, Andriy Yabluchanskiy
Obesity is one of the major risk factors for cardiovascular diseases and its prevalence is increasing in all age groups, with the biggest impact observed in middle-aged and older adults. A critical mechanism by which obesity promotes vascular pathologies in these patients involves impairment of endothelial function. While endothelial dysfunction in large vessels promotes atherogenesis, obesity-induced microvascular endothelial dysfunction impairs organ perfusion and thereby is causally related to the pathogenesis of ischemic heart disease, chronic kidney disease, intermittent claudication, exercise intolerance, and exacerbates cognitive decline in aging...
June 18, 2018: GeroScience
https://www.readbyqxmd.com/read/29915639/a-case-of-concomitant-obstructive-sleep-apnea-and-non-alcoholic-steatohepatitis-treated-with-cpap-therapy
#9
Bharat Bajantri, Dmitry Lvovsky
Obstructive sleep apnea syndrome is a disorder of sleep breathing that is a result of recurrent and intermittent hypoxia during sleep induced by the repeated partial or complete collapse of the upper airway, eventually causing chronic intermittent hypoxia. Non-alcoholic fatty liver disease is divided into non-alcoholic fatty liver and non-alcoholic steatohepatitis. Animal and human studies showed that obesity is associated with chronic liver hypoxia, even in the presence of systemic normoxia causing inflammation and release of cytokines...
June 2018: Gastroenterology Research
https://www.readbyqxmd.com/read/29915361/amp-kinase-promotes-glioblastoma-bioenergetics-and-tumour-growth
#10
Rishi Raj Chhipa, Qiang Fan, Jane Anderson, Ranjithmenon Muraleedharan, Yan Huang, Georgianne Ciraolo, Xiaoting Chen, Ronald Waclaw, Lionel M Chow, Zaza Khuchua, Matthew Kofron, Matthew T Weirauch, Ady Kendler, Christopher McPherson, Nancy Ratner, Ichiro Nakano, Nupur Dasgupta, Kakajan Komurov, Biplab Dasgupta
Stress is integral to tumour evolution, and cancer cell survival depends on stress management. We found that cancer-associated stress chronically activates the bioenergetic sensor AMP kinase (AMPK) and, to survive, tumour cells hijack an AMPK-regulated stress response pathway conserved in normal cells. Analysis of The Cancer Genome Atlas data revealed that AMPK isoforms are highly expressed in the lethal human cancer glioblastoma (GBM). We show that AMPK inhibition reduces viability of patient-derived GBM stem cells (GSCs) and tumours...
June 18, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29914467/exercise-and-physical-activity-in-asylum-seekers-in-northern-england-using-the-theoretical-domains-framework-to-identify-barriers-and-facilitators
#11
Melanie Haith-Cooper, Catherine Waskett, Jane Montague, Maria Horne
BACKGROUND: Many asylum seekers have complex mental health needs which can be exacerbated by the challenging circumstances in which they live and difficulties accessing health services. Regular moderate physical activity can improve mental health and would be a useful strategy to achieve this. Evidence suggests there are barriers to engaging black and minority ethnic groups in physical activity, but there is little research around asylum seekers to address the key barriers and facilitators in this group...
June 19, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29913553/zmynd17-controls-muscle-mitochondrial-quality-and-whole-body-metabolism
#12
Ryo Fujita, Kiyoshi Yoshioka, Daiki Seko, Takashi Suematsu, Satomi Mitsuhashi, Nanami Senoo, Shinji Miura, Ichizo Nishino, Yusuke Ono
Muscle mitochondria are crucial for systemic metabolic function, yet their regulation remains unclear. The zinc finger MYND domain-containing protein 17 (Zmynd17) was recently identified as a muscle-specific gene in mammals. Here, we investigated the role of Zmynd17 in mice. We found Zmynd17 predominantly expressed in skeletal muscle, especially in fast glycolytic muscle. Genetic Zmynd17 inactivation led to morphologic and functional abnormalities in muscle mitochondria, resulting in decreased respiratory function...
April 13, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29910757/endurance-and-resistance-trained-men-exhibit-lower-cardiovascular-responses-to-psychosocial-stress-than-untrained-men
#13
Peter Gröpel, Maren Urner, Jens C Pruessner, Markus Quirin
Evidence shows that regular physical exercise reduces physiological reactivity to psychosocial stress. However, previous research mainly focused on the effect of endurance exercise, with only a few studies looking at the effect of resistance exercise. The current study tested whether individuals who regularly participate in either endurance or resistance training differ from untrained individuals in adrenal and cardiovascular reactivity to psychosocial stress. Twelve endurance-trained men, 10 resistance-trained men, and 12 healthy but untrained men were exposed to a standardized psychosocial stressor, the Trier Social Stress Test...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29910415/acute-and-chronic-effects-of-isometric-handgrip-exercise-on-cardiovascular-variables-in-hypertensive-patients-a-systematic-review
#14
REVIEW
Breno Q Farah, Antônio H Germano-Soares, Sergio Luiz C Rodrigues, Camila X Santos, Sávio S Barbosa, Lauro C Vianna, Véronique A Cornelissen, Raphael M Ritti-Dias
The aim of this study was to describe, through a systematic review, the acute and chronic effects of isometric handgrip exercise on cardiovascular variables in hypertensive individuals. In this systematic review, we included studies that analyzed whether a single bout or a program with isometric exercises affect cardiovascular variables in hypertensive adults. The electronic database PubMed/Medline was searched for relevant studies published until May 2017. Of the 2927 studies initially identified, 2916 were excluded based on title and abstract and five on the basis of full-text assessment, leaving six studies remaining...
August 1, 2017: Sports
https://www.readbyqxmd.com/read/29910360/next-day-subjective-and-objective-recovery-indices-following-acute-low-and-high-training-loads-in-academy-rugby-union-players
#15
Mark R Noon, Rob S James, Neil D Clarke, Richard J Taylor, C Douglas Thake
The aim of this study was to determine the sensitivity of selected subjective and objective monitoring assessments in detecting changes in group and individual responses to low and high load bouts of high intensity intermittent exercise. In a counterbalanced crossover design, Thirteen Academy Rugby Union players (mean ± SD: age: 18 ± 1 years) performed a low load (15 min) and a high load (90 min) bout of high intensity intermittent exercise (Loughborough Intermittent Shuttle Test) one week apart. Monitoring assessments were performed immediately prior to and 20 h following each trial...
June 15, 2018: Sports
https://www.readbyqxmd.com/read/29910327/non-contact-respiration-measurement-during-exercise-tolerance-test-by-using-kinect-sensor
#16
Hirooki Aoki, Hidetoshi Nakamura
This study aims to assess non-contact respiration measurement during the exercise stress test using an upright bicycle ergometer and to evaluate the ventilation threshold value. We propose the tracking of the chest and abdomen by applying the motion capture function of the Kinect V2 sensor to cope with an increase in physical exercise accompanied by an increase in exercise intensity. In the proposed method, the region enclosed by the four joints corresponding to the left and right shoulders and the right and left hip extracted using the Kinect sensor is set as the region of interest...
March 13, 2018: Sports
https://www.readbyqxmd.com/read/29907818/speckle-tracking-stress-echocardiography-in-children-interobserver-and-intraobserver-reproducibility-and-the-impact-of-echocardiographic-image-quality
#17
Lucia Wilke, Francisca E Abellan Schneyder, Markus Roskopf, Andreas C Jenke, Andreas Heusch, Kai O Hensel
Speckle tracking echocardiography (STE) is increasingly used during functional assessments. However, reproducibility and dependence on echocardiographic image quality for speckle tracking stress echocardiography in pediatric patients have not been studied to date. 127 consecutive normotensive children without structural heart disease (mean age 13.4 ± 3.0 years, 50.4% female) underwent a stepwise semisupine cycle ergometric protocol. Left ventricular (LV) myocardial peak strain and strain rate were assessed at rest and during exercise...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907335/trial-protocol-the-use-of-mindfulness-based-intervention-for-improving-bracing-compliance-for-adolescent-idiopathic-scoliosis-patients-protocol-for-a-randomised-controlled-trial
#18
Benjamin Hon Kei Yip, Xue Li, Christine Hiu Yan Leung, Ting Gao, Vincent Chi Ho Chung, Fiona Wai Ping Yu, Tsz Ping Lam, Jack Chun Yiu Cheng, Samuel Yeung Shan Wong
INTRODUCTION: Adolescent idiopathic scoliosis (AIS) is the most prevalent deforming orthopaedic condition; it causes significant disability when spinal curves progress beyond 45deg. Bracing is the primary treatment prescribed for adolescents with an immature skeleton who have spinal curves between 25 and 45deg. New evidence suggests that compliance with bracing significantly decreases the progression of high-risk curves to the threshold for surgery. Nonetheless, bracing is a stressful experience...
June 12, 2018: Journal of Physiotherapy
https://www.readbyqxmd.com/read/29907240/effect-of-programmed-exercise-on-perceived-stress-in-middle-aged-and-old-women-a-meta-analysis-of-randomized-trials
#19
REVIEW
Meletios P Nigdelis, Samuel J Martínez-Domínguez, Dimitrios G Goulis, Faustino R Pérez-López
OBJECTIVE: To clarify the effect of programmed exercise (PE), performed for at least six weeks, on perceived stress (PS) in middle aged and old women. METHODS: A structured search was carried out in PubMed, Embase, Cochrane Library, Scielo, Web of Science and Scopus, from database inception through January 10, 2018, without language restriction. The US, UK, and Australian clinical trials databases were also searched. The search included a combination of the terms "programmed exercise", "perceived stress", "menopausal women" and "randomized controlled trial" (RCTs)...
August 2018: Maturitas
https://www.readbyqxmd.com/read/29907153/comparison-of-two-low-fat-diets-differing-in-protein-and-carbohydrate-on-psychological-wellbeing-in-adults-with-obesity-and-type-2-diabetes-a-randomised-clinical-trial
#20
Nerylee Ann Watson, Kathryn Ann Dyer, Jonathan David Buckley, Grant David Brinkworth, Alison Mary Coates, Gaynor Parfitt, Peter Ranald Charles Howe, Manny Noakes, Karen Joy Murphy
BACKGROUND: Although higher-protein diets (HP) can assist with weight loss and glycemic control, their effect on psychological wellbeing has not been established. The objective of this study was to compare the effects of a HP and a higher-carbohydrate diet (HC), combined with regular exercise, on psychological wellbeing both during weight loss (WL) and weight maintenance phases (WM). METHODS: In a parallel RCT, 61 adults with T2D (mean ± SD: BMI 34.3 ± 5...
June 15, 2018: Nutrition Journal
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