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https://www.readbyqxmd.com/read/27928968/rationale-for-assessing-safety-and-efficacy-of-drug-candidates-alone-and-in-combination-with-medical-devices-the-case-study-of-spinalontm
#1
Pierre A Guertin
The aim of this review is to describe the rationale and main underlying reasons for undertaking, during clinical development, the study of drug candidates used separately and/or in combination with other technologies. To ease comprehension, reference will be made to the case of SpinalonTM, a new fixed-dose combination (FDC) product composed of levodopa/carbidopa/buspirone. This drug is capable of triggering, within minutes after a single administration orally, 45 minute- episodes of basic involuntary 'reflex' walking in paraplegic animals...
December 7, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27922541/effects-of-the-5-ht1a-receptor-agonists-buspirone-and-8-oh-dpat-on-pupil-size-in-common-marmosets
#2
Manato Kotani, Naoko Urushino, Itaru Natsutani, Yuji Ogi, Kazuhito Ikeda
As pupil size is affected by psychotropic drugs in all mammals, it has been used as a well-established clinical indicator for the preclinical and clinical development of novel drugs. It has been reported that activation of the serotonin (5-HT)1A receptor differently affects pupil response in rodents (mydriasis) and humans (miosis). Thus, it is important to establish a quantitative system for measuring pupil size using other species, such as nonhuman primates. Common marmosets have recently attracted a great deal of attention as suitable experimental animals in the psychoneurological field because of handling ease compared with other nonhuman primates and the requirement for small amounts of test drugs...
December 2, 2016: Behavioural Pharmacology
https://www.readbyqxmd.com/read/27916394/hypoactive-sexual-desire-disorder-international-society-for-the-study-of-women-s-sexual-health-isswsh-expert-consensus-panel-review
#3
REVIEW
Irwin Goldstein, Noel N Kim, Anita H Clayton, Leonard R DeRogatis, Annamaria Giraldi, Sharon J Parish, James Pfaus, James A Simon, Sheryl A Kingsberg, Cindy Meston, Stephen M Stahl, Kim Wallen, Roisin Worsley
The objective of the International Society for the Study of Women's Sexual Health expert consensus panel was to develop a concise, clinically relevant, evidence-based review of the epidemiology, physiology, pathogenesis, diagnosis, and treatment of hypoactive sexual desire disorder (HSDD), a sexual dysfunction affecting approximately 10% of adult women. Etiologic factors include conditions or drugs that decrease brain dopamine, melanocortin, oxytocin, and norepinephrine levels and augment brain serotonin, endocannabinoid, prolactin, and opioid levels...
November 30, 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27911381/a-novel-approach-for-the-administration-of-medications-and-fluids-in-emergency-scenarios-and-settings
#4
Akilesh Honasoge, Neal Lyons, Kathleen Hesse, Braden Parker, Robert Mokszycki, Kelly Wesselhoff, Rolla Sweis, Erik B Kulstad
The available routes of administration commonly used for medications and fluids in the acute care setting are generally limited to oral, intravenous, or intraosseous routes, but in many patients, particularly in the emergency or critical care settings, these routes are often unavailable or time-consuming to access. A novel device is now available that offers an easy route for administration of medications or fluids via rectal mucosal absorption (also referred to as proctoclysis in the case of fluid administration and subsequent absorption)...
November 9, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27868310/the-serotonergic-anxiolytic-buspirone-attenuates-circadian-responses-to-light
#5
Victoria M Smith, Stephanie Iannattone, Sanjay Achal, Ryan T Jeffers, Michael C Antle
No abstract text is available yet for this article.
November 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27859267/human-motoneurone-excitability-is-depressed-by-activation-of-5ht1a-receptors-with-buspirone
#6
Jessica M D'Amico, Annie A Butler, Martin E Héroux, Florence Cotel, Jean-François M Perrier, Jane E Butler, Simon C Gandevia, Janet L Taylor
Intense serotonergic drive in the turtle spinal cord results in serotonin spillover to the axon initial segment of the motoneurones where it activates 5HT1A receptors and inhibits generation of action potentials. We examined whether activation of 5HT1A receptors decreases motoneurone excitability in humans by determining the effects of a 5HT1A receptor partial agonist, buspirone, on F waves and cervicomedullary motor evoked potentials (CMEPs). In a placebo-controlled double-blind study, 10 participants were tested on two occasions where either placebo or 20 mg buspirone was administered orally...
November 17, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27843317/effect-of-yi-nao-jie-yu-decoction-on-%C3%AE-aminobutyric-acid-type-a-receptor-in-the-hippocampus-and-serum-inflammatory-factors-in-a-rat-model-of-poststroke-anxiety
#7
Wen Zhang, Ruizhen Zhao, Xiaoli Li, Xia Cui, Zijun Zhao, Yingqiu Mao, Fengzhi Wu, Qisheng Tang
BACKGROUND: The Yi-nao-jie-yu decoction (YNJYD) is a herbal preparation widely used in the clinics of traditional Chinese medicine and has been recently used as an important new therapeutic agent in poststroke anxiety (PSA). The neuroendocrine-immune system plays an important role in PSA mechanisms, although the modulating effects of YNJYD remain unknown. This study investigated the potential effects of YNJYD on the neuroendocrine-immune system in a rat model of PSA. MATERIALS AND METHODS: The PSA model was induced by injecting collagenase (type VII) into the right globus pallidus, accompanied by empty water bottle stimulation for 2 weeks...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27803469/development-of-hplc-method-for-the-determination-of-buspirone-in-rat-plasma-using-fluorescence-detection-and-its-application-to-a-pharmacokinetic-study
#8
Ki Taek Kim, Jae-Young Lee, Ju-Hwan Park, Min Hwan Kim, Ji-Su Kim, Hyeon-Jong Shin, Naewon Kang, Hyun-Jong Cho, In-Soo Yoon, Dae-Duk Kim
A simple and sensitive analytical method for the quantitative determination of buspirone in rat plasma by HPLC with fluorescence detection was developed and validated using naproxen as an internal standard. A relatively small-volume (150 µL) aliquot of rat plasma sample was prepared by a simple deproteinization procedure using acetonitrile as a precipitating organic solvent. Chromatographic separation was performed using Kinetex(®) C8 column with an isocratic mobile phase consisting of acetonitrile and 10-mM potassium phosphate buffer (pH 6...
2016: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27742411/inhibition-of-reinforcing-hyperalgesic-and-motor-effects-of-morphine-by-buspirone-in-rats
#9
Darakhshan Jabeen Haleem, Shazia Nawaz
: Morphine and other opioids are among the most effective prescription medications for the treatment of pain. Addiction and hyperalgesia associated with their long-term use limits the clinical utility of these drugs. In view of a role of somatodendritic serotonin-1A receptors in addiction and analgesic effects of morphine, the present study concerns effects of co-use of buspirone, a partial agonist at the serotonin-1A receptor, on reinforcing, hyperalgesic, and motor effects of morphine in rats...
October 11, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27697553/acute-buspirone-dosing-enhances-abuse-related-subjective-effects-of-oral-methamphetamine
#10
Erika Pike, William W Stoops, Craig R Rush
There is not an approved pharmacotherapy for treating methamphetamine use disorder. This study sought to determine the effects of acute buspirone treatment on the subjective and cardiovascular effects of oral methamphetamine in order to provide an initial assessment of the utility, safety, and tolerability of buspirone for managing methamphetamine use disorder. We predicted that acute buspirone administration would reduce the subjective effects of methamphetamine. We also predicted that the combination of buspirone and methamphetamine would be safe and well tolerated...
November 2016: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/27652229/the-drug-treatment-of-delayed-ejaculation
#11
REVIEW
Ibrahim A Abdel-Hamid, Moustafa A Elsaied, Taymour Mostafa
Delayed ejaculation (DE) is an uncommon and a challenging disorder to treat. It is often quite concerning to patients and it can affect psychosocial well-being. Here we reviewed how DE is treated pharmacologically .We also highlighted specific settings where drugs could be introduced to medical practice. Electronic databases were searched from 1966 to February 2016, including PubMed MEDLINE, EMBASE, EBCSO Academic Search Complete, Cochrane Systematic Reviews Database, and Google Scholar using key words; delayed ejaculation, retarded ejaculation, inhibited ejaculation, drugs, treatment, or pharmacology...
August 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/27591870/the-role-of-5-ht1a-receptors-in-long-term-adaptation-of-newborn-rats-to-hypoxia
#12
V A Mikhailenko, I P Butkevich
We studied the effects of neonatal hypoxia on adaptive behavior of rats during prepubertal and pubertal periods in the control and after repeated injections of 5-HT1A receptor agonist buspirone. Hypoxia enhanced the inflammatory nociceptive response and exacerbated the depressive-like behavior. Repeated injections of buspirone starting from the neonatal period produced a long-term normalizing effect on the inflammatory nociceptive response and psychoemotional behavior disturbed by hypoxia. The protective effect of buspirone can result from strengthening of the adaptive potencies of the serotoninergic system via activation of 5-HT1A receptors that up-regulate secretion of trophic factor S100β under conditions of serotonin deficiency typical of rats exposed to neonatal hypoxia...
August 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27586891/the-5-ht1a-receptor-agonist-buspirone-improves-esophageal-motor-function-and-symptoms-in-systemic-sclerosis-a-4-week-open-label-trial
#13
George P Karamanolis, Stylianos Panopoulos, Konstantinos Denaxas, Anastasios Karlaftis, Alexandra Zorbala, Dimitrios Kamberoglou, Spiros D Ladas, Petros P Sfikakis
BACKGROUND: Acute administration of the oral 5-HT1A receptor agonist buspirone, which is commonly used as an anxiolytic drug, may improve compromised lower esophageal sphincter function. In an open-label trial we assessed the effects of buspirone on esophageal motor function and symptoms in patients with esophageal involvement associated with systemic sclerosis (SSc). METHODS: Thirty consecutive patients with SSc and symptomatic esophageal involvement, despite treatment with proton pump inhibitors, underwent high resolution manometry and chest computed tomography for assessment of motor function and esophageal dilatation, respectively...
September 1, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27444984/drug-interactions-between-hormonal-contraceptives-and-psychotropic-drugs-a-systematic-review
#14
Erin N Berry-Bibee, Myong-Jin Kim, Katharine B Simmons, Naomi K Tepper, Halley E M Riley, H Pamela Pagano, Kathryn M Curtis
OBJECTIVE: To examine whether the co-administration of hormonal contraceptives (HC) and psychotropic drugs commonly used to treat anxiety and/or depression results in safety or efficacy concerns for either drug. METHODS: We searched PubMed and Cochrane libraries for clinical or pharmacokinetic (PK) studies that examined co-administration of any HC with psychotropic drugs [selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), oral benzodiazepines, bupropion, mirtazapine, trazadone, buspirone, hydroxyzine, monoamine oxidase inhibitors (MAOIs), or atypical antipsychotics] in reproductive aged women...
July 18, 2016: Contraception
https://www.readbyqxmd.com/read/27436722/nucleus-incertus-contributes-to-an-anxiogenic-effect-of-buspirone-in-rats-involvement-of-5-ht1a-receptors
#15
Jigna Rajesh Kumar, Ramamoorthy Rajkumar, Liying Corinne Lee, Gavin S Dawe
The nucleus incertus (NI), a brainstem structure with diverse anatomical connections, is implicated in anxiety, arousal, hippocampal theta modulation, and stress responses. It expresses a variety of neurotransmitters, neuropeptides and receptors such as 5-HT1A, D2 and CRF1 receptors. We hypothesized that the NI may play a role in the neuropharmacology of buspirone, a clinical anxiolytic which is a 5-HT1A receptor partial agonist and a D2 receptor antagonist. Several preclinical studies have reported a biphasic anxiety-modulating effect of buspirone but the precise mechanism and structures underlying this effect are not well-understood...
November 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27421270/new-pharmacological-agents-to-aid-smoking-cessation-and-tobacco-harm-reduction-what-has-been-investigated-and-what-is-in-the-pipeline
#16
REVIEW
Emma Beard, Lion Shahab, Damian M Cummings, Susan Michie, Robert West
A wide range of support is available to help smokers to quit and to aid attempts at harm reduction, including three first-line smoking cessation medications: nicotine replacement therapy, varenicline and bupropion. Despite the efficacy of these, there is a continual need to diversify the range of medications so that the needs of tobacco users are met. This paper compares the first-line smoking cessation medications with (1) two variants of these existing products: new galenic formulations of varenicline and novel nicotine delivery devices; and (2) 24 alternative products: cytisine (novel outside Central and Eastern Europe), nortriptyline, other tricyclic antidepressants, electronic cigarettes, clonidine (an anxiolytic), other anxiolytics (e...
October 2016: CNS Drugs
https://www.readbyqxmd.com/read/27417180/an-automated-high-throughput-metabolic-stability-assay-using-an-integrated-high-resolution-accurate-mass-method-and-automated-data-analysis-software
#17
Pranav Shah, Edward Kerns, Dac-Trung Nguyen, R Scott Obach, Amy Q Wang, Alexey Zakharov, John McKew, Anton Simeonov, Cornelis E C A Hop, Xin Xu
Advancement of in silico tools would be enabled by the availability of data for metabolic reaction rates and intrinsic clearance (CLint) of a diverse compound structure data set by specific metabolic enzymes. Our goal is to measure CLint for a large set of compounds with each major human cytochrome P450 (P450) isozyme. To achieve our goal, it is of utmost importance to develop an automated, robust, sensitive, high-throughput metabolic stability assay that can efficiently handle a large volume of compound sets...
October 2016: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/27384395/the-psychopharmacology-algorithm-project-at-the-harvard-south-shore-program-an-algorithm-for-generalized-anxiety-disorder
#18
Harmony Raylen Abejuela, David N Osser
This revision of previous algorithms for the pharmacotherapy of generalized anxiety disorder was developed by the Psychopharmacology Algorithm Project at the Harvard South Shore Program. Algorithms from 1999 and 2010 and associated references were reevaluated. Newer studies and reviews published from 2008-14 were obtained from PubMed and analyzed with a focus on their potential to justify changes in the recommendations. Exceptions to the main algorithm for special patient populations, such as women of childbearing potential, pregnant women, the elderly, and those with common medical and psychiatric comorbidities, were considered...
July 2016: Harvard Review of Psychiatry
https://www.readbyqxmd.com/read/27333080/color-preference-in-danio-rerio-effects-of-age-and-anxiolytic-treatments
#19
Bernardus W M M Peeters, Max Moeskops, Anne R J Veenvliet
Zebrafish are increasingly used in neurobiological and behavioral studies. Possible stimuli to manipulate zebrafish behavior are being investigated. The presentation of colors appears to be one of the most used approaches, but there is much debate about the exact color preference. Here we have investigated the color preference in both larvae and adult zebrafish. We have studied the effects of wavelength, contrast, intensity, and location. Furthermore, we have tried to manipulate the preference with anxiolytic drugs (ethanol and buspirone)...
August 2016: Zebrafish
https://www.readbyqxmd.com/read/27332558/functional-dyspepsia-and-gastroparesis
#20
Michael Camilleri
BACKGROUND: Upper gastrointestinal disorders typically present with common symptoms. The most relevant non-mucosal diseases are gastroparesis, functional dyspepsia and rumination syndrome. The literature pertaining to these 3 conditions was reviewed. KEY MESSAGES: Gastroparesis is characterized by delayed gastric emptying in the absence of mechanical obstruction of the stomach. The cardinal symptoms include postprandial fullness (early satiety), nausea, vomiting and bloating...
2016: Digestive Diseases
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