keyword
MENU ▼
Read by QxMD icon Read
search

Buspirone

keyword
https://www.readbyqxmd.com/read/29782941/dopamine-and-serotonin-metabolism-associated-with-morphine-reward-and-its-inhibition-with-buspirone-a-study-in-the-rat-striatum
#1
Darakhshan Jabeen Haleem, Shazia Nawaz, Tabinda Salman
Adaptations within the nucleus accumbens (NAc) and caudate nucleus (CN) dopamine neurotransmission are involved in behavioral sensitization and enhanced incentive motivation towards drug paired stimuli which lead to drug addiction. Serotonin (5-hydroxytryptamine; 5-HT) can modulate dopamine neurotransmission to reduce rewarding effects of drugs of abuse. A recent study from our laboratory shows that rewarding effects of morphine are inhibited in rats co-treated with buspirone. To understand the neurochemical mechanism involved in morphine addiction and its inhibition with buspirone, present study determines the effects of buspirone, morphine and their co-administration on the metabolism of serotonin and dopamine in the NAc and CN...
May 18, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29766823/analysis-of-toxicity-effects-of-buspirone-cetirizine-and-olanzapine-on-human-blood-lymphocytes-in-vitro-model
#2
Jalal Pourahmad, Ahmad Salimi, Mosleh Razian
The current study investigates the cytotoxicity mechanism of common drugs with piperazine ring such as cetirizine, olanzapine and buspirone on human lymphocytes. The viability of lymphocytes, reactive oxygen species (ROS) formation, mitochondrial membrane potential (MMP) collapse, lysosomal integrity, content of glutathione and lipid peroxidation were determined. Buspirone and cetirizine showed more toxicity than olanzapine on human lymphocytes with an IC50 value of 200 μg/ml, after 6 h of incubation. Significant ROS formation, MMP collapse, lipid peroxidation, lysosomal damage and elevation of glutathione disulfide (GSSG) were observed in treated lymphocytes concentrations (4, 20, 40 µg/ml) of buspirone and cetirizine...
May 15, 2018: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/29716850/methylphenidate-induced-hepatotoxicity-in-rats-and-its-reduction-by-buspirone
#3
Nausheen Alam, Rahila Ikram
Methylphenidate is commonly use for the treatment of attention deficit hyperactivity disorder (ADHD), but its long term use was found to produce hepatic necrosis in mice. Purpose of this study was to investigate that co-administration of buspirone (drug which attenuates methylphenidate induced sensitization) may attenuate methylphenidate-induced hepatotoxic effects and to determine the effect of challenge dose of haloperidol (D2 antagonist that blocks the effects of methylphenidate in case of intoxication) on SGPT and SGOT levels in methylphenidate treated rats...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29708207/ssri-associated-bruxism-a-systematic-review-of-published-case-reports
#4
REVIEW
Andrew R Garrett, Jason S Hawley
Purpose of review: Antidepressant-associated movement disorders are a well-described phenomenon. However, antidepressant-associated bruxism, jaw pain, or jaw spasm, while reported in dental literature, is less commonly recognized among neurologists. We summarize the clinical features and treatment of antidepressant-associated bruxism and associated jaw pain through a systematic review of case reports. Recent findings: Antidepressant-associated bruxism may occur in pediatric and adult patients, most commonly among female patients...
April 2018: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/29693461/an-update-on-pharmacotherapy-of-autism-spectrum-disorder-in-children-and-adolescents
#5
Ritu Goel, Ji Su Hong, Robert L Findling, Na Young Ji
To date, no medication is proven to be effective in treating core symptoms of autism spectrum disorder (ASD). Psychotropic medications are widely used to target emotional and behavioural symptoms in ASD. This article reviewed evidence for pharmacotherapy, novel therapeutic agents, and Complementary and Alternative Medicine (CAM) in children and adolescents with ASD. Currently, only risperidone and aripiprazole have been approved by the US Food and Drug Administration (FDA) for treatment of irritability associated with ASD in children and adolescents...
April 25, 2018: International Review of Psychiatry
https://www.readbyqxmd.com/read/29677541/tert-butyl-4-1-phenyl-1h-pyrazol-4-yl-methyl-piperazine-1-carboxylate-lqfm104-new-piperazine-derivative-with-antianxiety-and-antidepressant-like-effects-putative-role-of-serotonergic-system
#6
Dayane Moreira da Silva, Germán Sanz, Boniek Gontijo Vaz, Flávio Silva de Carvalho, Luciano Morais Lião, Danillo Ramos de Oliveira, Lorrane Kelle da Silva Moreira, Carina Sofia Cardoso, Adriane Ferreira de Brito, Daiany Priscilla Bueno da Silva, Fabio Fagundes da Rocha, Ianca Gontijo Cavalcante Santana, Pablinny Moreira Galdino, Elson Alves Costa, Ricardo Menegatti
The piperazine derivatives correspond to an extensive chemical class of compounds with numerous neuropharmacological activities, including antidepressant (e.g., nefazodone, trazodone) and anxiolytic (e.g., buspirone) properties. Therefore, aiming to identify a new antidepressant and antianxiety lead-compound, our group designed, synthesized, and investigated the effects of a new piperazine compound, namely, LQFM104, on the behavior of mice. Male albino Swiss mice were treated with LQFM104 prior to predictive behavioral tests as open field (OFT), elevated plus maze (EPM), forced swimming (FST), and tail suspension tests (TST)...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29648984/facilitation-of-locomotor-spinal-networks-activity-by-buspirone-after-a-complete-spinal-cord-lesion-in-mice
#7
Renaud Jeffrey-Gauthier, Nicolas Josset, Frédéric Bretzner, Hugues Leblond
Despite efforts to potentiate spinal cord lesioned (SCL) patients' functional recovery with multi-targeted therapy combining pharmacological treatment and training, consistent improvements in locomotor control by descending transmission or spinal network facilitation are still eluding clinicians and researchers. Lately, US Food and Drug Administration-approved buspirone has shown promise and promoted locomotor-like movement occurrence in SCL patients, but evidence on how and where it exerts its effects is lacking...
March 16, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29642718/psychotropic-pharmacotherapy-associated-with-qt-prolongation-among-veterans-with-posttraumatic-stress-disorder
#8
Eileen M Stock, John E Zeber, Catherine J McNeal, Javier E Banchs, Laurel A Copeland
BACKGROUND: In 2012, the Food and Drug Administration issued Drug Safety Communications on several drugs associated with QT prolongation and fatal ventricular arrhythmias. Among these was citalopram, a selective serotonin reuptake inhibitor (SSRI) approved for depression and commonly used for posttraumatic stress disorder (PTSD). Evaluation of the risk for QT prolongation among other psychotropic drugs for individuals with PTSD remains limited. OBJECTIVE: Explore psychotropic drugs associated with QT prolongation among veterans with PTSD...
April 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29552749/miscellaneous-treatments-for-antipsychotic-induced-tardive-dyskinesia
#9
REVIEW
Karla Soares-Weiser, John Rathbone, Yusuke Ogawa, Kiyomi Shinohara, Hanna Bergman
BACKGROUND: Antipsychotic (neuroleptic) medication is used extensively to treat people with chronic mental illnesses. Its use, however, is associated with adverse effects, including movement disorders such as tardive dyskinesia (TD) - a problem often seen as repetitive involuntary movements around the mouth and face. This review, one in a series examining the treatment of TD, covers miscellaneous treatments not covered elsewhere. OBJECTIVES: To determine whether drugs, hormone-, dietary-, or herb-supplements not covered in other Cochrane reviews on TD treatments, surgical interventions, electroconvulsive therapy, and mind-body therapies were effective and safe for people with antipsychotic-induced TD...
March 19, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29507463/evaluation-and-management-of-esophageal-manifestations-in-systemic-sclerosis
#10
REVIEW
Konstantinos Denaxas, Spyros D Ladas, George P Karamanolis
Systemic sclerosis (SSc) is a multisystemic autoimmune connective tissue disorder; in the gastrointestinal tract, the esophagus is the most commonly affected organ. Symptoms of esophageal disease are due to gastroesophageal reflux disease (GERD) and esophageal motor dysfunction. Since the development of high-resolution manometry (HRM), this method has been preferred for the study of SSc patients with esophageal involvement. Using HRM, classic scleroderma esophagus, defined as absent or ineffective peristalsis of the distal esophagus in combination with a hypotensive lower esophageal sphincter, was found in as many as 55% of SSc patients...
March 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29464791/comparing-pharmacological-treatments-for-cocaine-dependence-incorporation-of-methods-for-enhancing-generalizability-in-meta-analytic-studies
#11
Ryoko Susukida, Rosa M Crum, Hwanhee Hong, Elizabeth A Stuart, Ramin Mojtabai
OBJECTIVES: Few head-to-head comparisons of cocaine dependence medications exist, and combining data from different randomized controlled trials (RCTs) is fraught with methodological challenges including limited generalizability of the RCT findings. This study applied a novel meta-analytic approach to data of cocaine dependence medications. METHODS: Data from 4 placebo-controlled RCTs (Reserpine, Modafinil, Buspirone, and Ondansetron) were obtained from the National Institute of Drug Abuse Clinical Trials Network (n = 456)...
February 21, 2018: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/29460165/efficacy-and-safety-of-drugs-for-attention-deficit-hyperactivity-disorder-in-children-and-adolescents-a-network-meta-analysis
#12
Sarah C O S Padilha, Suzane Virtuoso, Fernanda S Tonin, Helena H L Borba, Roberto Pontarolo
The aim of this study is to gather evidence of head-to-head double-blind randomized-controlled trials on the efficacy and safety of available treatments for attention deficit hyperactivity disorder (ADHD) in children and adolescents. A systematic review was conducted by two independent reviewers in ten electronic databases (PROSPERO register CRD42016043239). Methodological quality of included studies was evaluated according to the Jadad scale. Network meta-analyses were performed including double-blinded head-to-head trials comparing active allopathic drugs in patients (0-18 years old) diagnosed with ADHD...
February 19, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29380709/formulation-and-evaluation-of-niosomal-in-situ-nasal-gel-of-a-serotonin-receptor-agonist-buspirone-hydrochloride-for-the-brain-delivery-via-intranasal-route
#13
Dyandevi Mathure, Jyotsana R Madan, Kishore N Gujar, Ashok Tupsamundre, Hemant A Ranpise, Kamal Dua
BACKGROUND: Buspirone Hydrochloride is an anxiolytic agent and serotonin receptor agonist belonging to azaspirodecanedione class of compounds used in the treatment of anxiety disorders. It has short half-life (2-3h) and low oral bioavailability (4%) due to extensive first pass metabolism. OBJECTIVE: The nasal mucosa has several advantages viz., large surface area, porous endothelial membrane, high blood flow, avoidance of first-pass metabolism and ready accessibility that lead to faster and higher drug absorption...
2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29315269/mining-the-potential-of-label-free-biosensors-for-in-vitro-antipsychotic-drug-screening
#14
Tugba Kilic, Maria Soler, Nafiseh Fahimi-Kashani, Hatice Altug, Sandro Carrara
The pharmaceutical industry is facing enormous challenges due to high drug attribution rates. For the past decades, novel methods have been developed for safety and efficacy testing, as well as for improving early development stages. In vitro screening methods for drug-receptor binding are considered to be good alternatives for decreasing costs in the identification of drug candidates. However, these methods require lengthy and troublesome labeling steps. Biosensors hold great promise due to the fact that label-free detection schemes can be designed in an easy and low-cost manner...
January 9, 2018: Biosensors
https://www.readbyqxmd.com/read/29289554/efficacy-and-safety-of-on-demand-use-of-2-treatments-designed-for-different-etiologies-of-female-sexual-interest-arousal-disorder-3-randomized-clinical-trials
#15
Adriaan Tuiten, Kim van Rooij, Jos Bloemers, Christoph Eisenegger, Jack van Honk, Rob Kessels, Sheryl Kingsberg, Leonard R Derogatis, Leo de Leede, Jeroen Gerritsen, Hans P F Koppeschaar, Berend Olivier, Walter Everaerd, Henderik W Frijlink, Daniël Höhle, Robert P J de Lange, Koen B E Böcker, James G Pfaus
BACKGROUND: In women, low sexual desire and/or sexual arousal can lead to sexual dissatisfaction and emotional distress, collectively defined as female sexual interest/arousal disorder (FSIAD). Few pharmaceutical treatment options are currently available. AIM: To investigate the efficacy and safety of 2 novel on-demand pharmacologic treatments that have been designed to treat 2 FSIAD subgroups (women with low sensitivity for sexual cues and women with dysfunctional over-activation of sexual inhibition) using a personalized medicine approach using an allocation formula based on genetic, hormonal, and psychological variables developed to predict drug efficacy in the subgroups...
February 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29278601/shivering-treatments-for-targeted-temperature-management-a-review
#16
Akash Jain, Maria Gray, Stephanie Slisz, Joseph Haymore, Neeraj Badjatia, Erik Kulstad
BACKGROUND: Shivering is common during targeted temperature management, and control of shivering can be challenging if clinicians are not familiar with the available options and recommended approaches. PURPOSE: The purpose of this review was to summarize the most relevant literature regarding various treatments available for control of shivering and suggest a recommended approach based on latest data. METHODS: The electronic databases PubMed/MEDLINE and Google Scholar were used to identify studies for the literature review using the following keywords alone or in combination: "shivering treatment," "therapeutic hypothermia," "core temperature modulation devices," and "targeted temperature management...
April 2018: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/29274869/neuromodulators-for-functional-gastrointestinal-disorders-disorders-of-gut-brain-interaction-a-rome-foundation-working-team-report
#17
REVIEW
Douglas A Drossman, Jan Tack, Alexander C Ford, Eva Szigethy, Hans Törnblom, Lukas Van Oudenhove
BACKGROUND & AIMS: Central neuromodulators (antidepressants, antipsychotics, and other central nervous system-targeted medications) are increasingly used for treatment of functional gastrointestinal disorders (FGIDs), now recognized as disorders of gut-brain interaction. However, the available evidence and guidance for the use of central neuromodulators in these conditions is scanty and incomplete. In this Rome Foundation Working Team report, a multidisciplinary team summarized available research evidence and clinical experience to provide guidance and treatment recommendations...
March 2018: Gastroenterology
https://www.readbyqxmd.com/read/29225554/recent-developments-in-psychopharmaceutical-approaches-to-treating-female-sexual-interest-and-arousal-disorder
#18
REVIEW
Stephanie Both
Purpose of Review: This review summarizes the recent literature and empirical studies on psychopharmacological approaches to treating female sexual interest/arousal disorder (FSIAD). Recent Findings: Several new drugs for FSIAD that are intended to increase sexual responsiveness by influencing central excitatory and inhibitory neuromodulatory processes are under development. Studies on flibanserin resulted in the first approved medication for the treatment of low sexual desire in premenopausal women...
2017: Current Sexual Health Reports
https://www.readbyqxmd.com/read/29198512/understanding-the-role-of-serotonin-in-female-hypoactive-sexual-desire-disorder-and-treatment-options
#19
REVIEW
Harry A Croft
BACKGROUND: The neurobiology of sexual response is driven in part by dopamine and serotonin-the former modulating excitatory pathways and the latter regulating inhibitory pathways. Neurobiological underpinnings of hypoactive sexual desire disorder (HSDD) are seemingly related to overactive serotonin activity that results in underactive dopamine activity. As such, pharmacologic agents that decrease serotonin, increase dopamine, or some combination thereof, have therapeutic potential for HSDD...
December 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29174529/adjunctive-azapirone-for-schizophrenia-a-meta-analysis-of-randomized-double-blind-placebo-controlled-trials
#20
Wei Zheng, Xiao-Hong Li, Dong-Bin Cai, Xin-Hu Yang, Gabor S Ungvari, Chee H Ng, Yu-Ping Ning, Yu-Tao Xiang
Azapirones, which are serotonin1A (5-HT1A ) receptor partial agonists, have been used as an adjunctive treatment for schizophrenia with mixed results. This is a meta-analysis of the efficacy and tolerability of azapirones for schizophrenia based on randomized, double-blind, placebo-controlled trials (RCTs). English and Chinese databases were systematically and independently searched by two investigators. Data were extracted and analyzed using the RevMan software (version 5.3). Seven RCTs (n = 368) of azapirones (buspirone in 6 RCTs and tandospirone in 1 RCT) were identified and analyzed...
January 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
keyword
keyword
11520
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"