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https://www.readbyqxmd.com/read/28642680/weight-bearing-over-ground-stepping-in-an-exoskeleton-with-non-invasive-spinal-cord-neuromodulation-after-motor-complete-paraplegia
#1
Parag Gad, Yury Gerasimenko, Sharon Zdunowski, Amanda Turner, Dimitry Sayenko, Daniel C Lu, V Reggie Edgerton
We asked whether coordinated voluntary movement of the lower limbs could be regained in an individual having been completely paralyzed (>4 year) and completely absent of vision (>15 year) using two novel strategies-transcutaneous electrical spinal cord stimulation at selected sites over the spine as well as pharmacological neuromodulation by buspirone. We also asked whether these neuromodulatory strategies could facilitate stepping assisted by an exoskeleton (EKSO, EKSO Bionics, CA) that is designed so that the subject can voluntarily complement the work being performed by the exoskeleton...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28612503/distinctive-in-vitro-signal-transduction-profile-of-nlx-112-a-potent-and-efficacious-serotonin-5-ht1a-receptor-agonist
#2
Adrian Newman-Tancredi, Jean-Claude Martel, Cristina Cosi, Peter Heusler, Fabrice Lestienne, Mark A Varney, Didier Cussac
OBJECTIVES: NLX-112 (befiradol, F13640) is a selective serotonin 5-HT1A receptor agonist. Although it has been tested in vivo, little has been reported on its in vitro signal transduction profile. METHODS: NLX-112 was tested on G-protein activation, inhibition of adenylyl cyclase, ERK1/2 phosphorylation (pERK) and receptor internalization in recombinant cell lines. NLX-112 was also tested on G-protein activation in rat hippocampal membranes. Gα subunit mRNA expression in cell lines and rat brain tissue was quantified by quantitative PCR...
June 14, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28602446/stiff-person-syndrome-presenting-after-the-initiation-of-buspirone
#3
Ibrahim Sablaban, Deepak Prabhakar
No abstract text is available yet for this article.
April 24, 2017: Psychosomatics
https://www.readbyqxmd.com/read/28535332/interventions-for-treating-anxiety-after-stroke
#4
REVIEW
Peter Knapp, C Alexia Campbell Burton, John Holmes, Jenni Murray, David Gillespie, C Elizabeth Lightbody, Caroline L Watkins, Ho-Yan Y Chun, Sharon R Lewis
BACKGROUND: Approximately 20% of stroke patients experience clinically significant levels of anxiety at some point after stroke. Physicians can treat these patients with antidepressants or other anxiety-reducing drugs, or both, or they can provide psychological therapy. This review looks at available evidence for these interventions. This is an update of the review first published in October 2011. OBJECTIVES: The primary objective was to assess the effectiveness of pharmaceutical, psychological, complementary, or alternative therapeutic interventions in treating stroke patients with anxiety disorders or symptoms...
May 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28508197/antinociceptive-effect-of-the-agonist-of-5-ht1a-receptors-buspirone-in-the-model-of-abdominal-pain-in-dogs
#5
O A Lyubashina, I I Busygina, S S Panteleev, A D Nozdrachev
We have demonstrated that activation of 5-HT1A receptors with buspirone promotes visceral analgesia in awake dogs. The administration of 0.035 mg/kg (i.m.) of the drug caused depression of viscero-motor (contraction of the abdominal muscles) and pressor (increase in the heart rate) responses to noxious distension of the large intestine. An increase in the dose to 0.07 and 0.14 mg/kg did not enhance the antinociceptive effect of buspirone but triggered basal tachycardia. The obtained results provide evidence of the inhibitory role of 5-HT1A receptors in modulating visceral pain sensitivity and the possibility of an exciting effect of their activation on the cardiovascular system...
March 2017: Doklady Biological Sciences: Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
https://www.readbyqxmd.com/read/28492455/reevaluating-antidepressant-selection-in-patients-with-bruxism-and-temporomandibular-joint-disorder
#6
Royce Rajan, Ye-Ming Sun
Temporomandibular joint disorder (TMD) is a broad pain disorder that refers to several conditions affecting the temporomandibular joint of the jaw and the muscles of mastication. As with most pain disorders, a high prevalence of depression and anxiety is associated with TMD. Research has shown that selective serotonin reuptake inhibitors (SSRIs), the first-line drug therapy for major depressive disorder, may not be suitable for TMD patients because SSRIs can induce teeth-grinding, otherwise known as bruxism...
May 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/28490916/the-cannabis-withdrawal-syndrome-current-insights
#7
REVIEW
Udo Bonnet, Ulrich W Preuss
The cannabis withdrawal syndrome (CWS) is a criterion of cannabis use disorders (CUDs) (Diagnostic and Statistical Manual of Mental Disorders - Fifth Edition) and cannabis dependence (International Classification of Diseases [ICD]-10). Several lines of evidence from animal and human studies indicate that cessation from long-term and regular cannabis use precipitates a specific withdrawal syndrome with mainly mood and behavioral symptoms of light to moderate intensity, which can usually be treated in an outpatient setting...
2017: Substance Abuse and Rehabilitation
https://www.readbyqxmd.com/read/28482015/a-new-paradigm-for-evaluating-avoidance-escape-motivation
#8
Iku Tsutsui-Kimura, Youcef Bouchekioua, Masaru Mimura, Kenji F Tanaka
Backgrounds: Organisms have evolved to approach pleasurable opportunities and to avoid or escape from aversive experiences. These two distinct motivations are referred to as approach and avoidance/escape motivations and are both considered vital for survival. Despite several recent advances in understanding the neurobiology of motivation, most studies addressed approach but not avoidance/escape motivation. Here we develop a new experimental paradigm to quantify avoidance/escape motivation and examine the pharmacological validity...
May 6, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28369597/exploring-chronic-drug-effects-on-microengineered-human-liver-cultures-using-global-gene-expression-profiling
#9
Brenton R Ware, Michael McVay, Wendy Y Sunada, Salman R Khetani
Global gene expression profiling is useful for elucidating a drug's mechanism of action (MOA) on the liver; however, such profiling in rats is not very sensitive for predicting human drug-induced liver injury, while de-differentiated monolayers of primary human hepatocytes (PHHs) do not permit chronic drug treatment. In contrast, micropatterned co-cultures (MPCCs) containing PHH colonies and 3T3-J2 fibroblasts maintain a stable liver phenotype for 4-6 weeks. Here, we used MPCCs to test the hypothesis that global gene expression patterns in stable PHHs can be used to distinguish clinical hepatotoxic drugs from their non-liver-toxic analogs and understand the MOA prior to the onset of overt hepatotoxicity...
March 24, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28301190/involvement-of-serotonin-and-oxytocin-in-neural-mechanism-regulating-amicable-social-signal-in-male-mice-implication-for-impaired-recognition-of-amicable-cues-in-balb-c-strain
#10
Hiroyuki Arakawa
Social signals play a primary role in regulating social relationships among male mice. The present series of experiments investigated the neural mechanisms underlying an induction of amicable cues that facilitate social approach in male mice of the C57BL/6 (B6) and BALB/c (BALB) strains. Male mice exhibit approach behavior and suppression of territorial scent marking toward amicable counterparts. Exposure of a group-housed mouse that maintains an amicable relationship induced social approach in B6 recipient mice, as expressed by increased preference of stay in proximity and decreased scent marks relevant to those of a single-housed mouse...
April 2017: Behavioral Neuroscience
https://www.readbyqxmd.com/read/28203348/flibanserin-for-hypoactive-sexual-desire-disorder-place-in-therapy
#11
REVIEW
Faina Gelman, Jessica Atrio
The pathophysiology, diagnosis and treatment of female sexual interest in pre- and post-menopausal women present a complex arena for patients and physicians to navigate. Flibanserin was the first pharmacologic treatment, approved by the United States Food and Drug Administration in August 2015, for hypoactive sexual desire disorder (HSDD) in premenopausal women. Side effects, contraindications and lack of approval in postmenopausal women are all limitations, as are issues surrounding patient and physician knowledge and access...
January 2017: Therapeutic Advances in Chronic Disease
https://www.readbyqxmd.com/read/28184190/long-term-effects-of-chronic-buspirone-during-adolescence-reduce-the-adverse-influences-of-neonatal-inflammatory-pain-and-stress-on-adaptive-behavior-in-adult-male-rats
#12
Irina P Butkevich, Viktor A Mikhailenko, Elena A Vershinina, Anna M Aloisi, Gordon A Barr
Neonatal pain and stress induce long-term changes in pain sensitivity and behavior. Previously we found alterations in pain sensitivity in adolescent rats exposed to early-life adverse events. We tested whether these alterations have long-lasting effects and if those effects can be improved by the 5-hydroxytryptamine 1A (5-HT1A) receptor agonist buspirone injected chronically during the adolescent period. This study investigates: (1) effects of inflammatory pain (the injection of formalin into the pad of a hind paw) or stress (short maternal deprivation-isolation, MI), or their combination in 1-2-day-old rats on the adult basal pain, formalin-induced pain, anxiety and depression; (2) effects of adolescent buspirone in adult rats that experienced similar early-life insults...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28124634/buspirone-for-the-treatment-of-dementia-with-behavioral-disturbance
#13
Maria R Santa Cruz, Priscilla C Hidalgo, Meredith S Lee, Cornelius W Thomas, Suzanne Holroyd
Behavioral disturbances are common but serious symptoms in patients with dementia. Currently, there are no FDA approved drugs for this purpose. There have been case reports and small case series of the use of buspirone. In this retrospective study, we review 179 patients prescribed buspirone for treatment of behavioral disturbance in dementia to better characterize the efficacy and potential side effects. All patients prescribed buspirone for behavioral disturbance due to dementia from a geropsychiatric outreach program were reviewed...
January 26, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28120485/effects-of-acute-buspirone-administration-on-inhibitory-control-and-sexual-discounting-in-cocaine-users
#14
Justin C Strickland, B Levi Bolin, Michael R Romanelli, Craig R Rush, William W Stoops
OBJECTIVE: Cocaine users display deficits in inhibitory control and make impulsive choices that may increase risky behavior. Buspirone is an anxiolytic that activates dopaminergic and serotonergic systems and improves impulsive choice (i.e., reduces sexual risk-taking intent) in cocaine users when administered chronically. We evaluated the effects of acutely administered buspirone on inhibitory control and impulsive choice. METHODS: Eleven subjects with a recent history of cocaine use completed this within-subject, placebo-controlled study...
January 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28111036/an-lc-ms-ms-method-for-the-simultaneous-determination-of-15-antipsychotics-and-two-metabolites-in-hair-and-its-application-to-rat-hair
#15
Juhyun Sim, Eunmi Kim, Wonkyung Yang, Sanghee Woo, Sangwhan In
In recent years, the inappropriate use of antipsychotics by young Korean men has become a social problem. As military service exemptions are given for mental illness, some men pose as mental health patients to avoid military service. In order to verify the authenticity of mental illnesses, we developed simultaneous analytical methods for the detection of 15 antipsychotics and 2 of their metabolites in hair using liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. The target drugs were modafinil, atomoxetine, aripiprazole, benztropine, buspirone, duloxetine, gabapentin, oxcarbazepine, topiramate, escitalopram, paliperidone, ziprasidone, lamotrigine, clonazepam, levetiracetam, and metabolites of oxcarbazepine and clonazepam...
May 2017: Forensic Science International
https://www.readbyqxmd.com/read/28080146/perceptions-vs-evidence-therapeutic-substitutes-for-antipsychotics-in-patients-with-dementia-in-long-term-care
#16
Brianne L Olivieri-Mui, John W Devlin, Aileen Ochoa, Danielle Schenck, Becky Briesacher
OBJECTIVE: To compare differences between clinician perceptions of therapeutic substitutes for antipsychotics prescribed to patients with dementia in long term care (LTC) and published evidence. METHODS: A mixed-methods approach that included a drug information search, online survey of 55 LTC clinicians and a comprehensive literature review was used. For 41 pharmacologic antipsychotic substitute candidates identified, LTC clinicians rated the likelihood they would substitute each for patients with dementia and identified non-pharmacologic antipsychotic substitutes...
January 12, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28061970/nitric-oxide-and-anxiety
#17
K Gulati, N Rai, A Ray
Anxiety is a common neuropsychiatric disorder which affects both physical and mental health. Complex neurobiological mechanisms are involved in the genesis of anxiety, and the drugs used to date, though effective, are not free from shortcomings. Conventional agents like the classical benzodiazepines and the atypical nonbenzodiazepine agents like buspirone have their own limitations. There is thus need to explore newer neurochemical pathways to develop efficacious and safer drugs for the disorder. Nitric oxide (NO) is a unique neuromodulator substance, with the ability to influence and modulate several other conventional messengers which play an important role in anxiety...
2017: Vitamins and Hormones
https://www.readbyqxmd.com/read/28025945/double-blind-placebo-controlled-randomized-phase-i-iia-study-safety-and-efficacy-with-buspirone-levodopa-carbidopa-spinalontm-in-subjects-with-complete-ais-a-or-motor-complete-ais-b-spinal-cord-injury
#18
Mohan Radhakrishna, Inge Steuer, François Prince, Mary Roberts, David Mongeon, Maryam Kia, Sasha Dyck R N, Gilbert Matte, Mario Vaillancourt, Pierre A Guertin
BACKGROUND: No drug treatment capable of restoring locomotor capabilities in patients suffering a motor-complete spinal cord injury (SCI) has ever been developed. We assessed the safety and efficacy of an activator of spinal locomotor neurons in humans, which were shown in paraplegic animals to elicit temporary episodes of involuntary walking. METHODS: Single administration of buspirone/levodopa/carbidopa (Spinalon TM), levodopa/carbidopa (ratio 4: 1), and buspirone or placebo was performed using a dose-escalation design in 45 subjects placed in supine position who had had an SCI classified as complete (AIS A) or motor-complete/sensory incomplete (AIS B) for at least 3 months...
December 27, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27928968/rationale-for-assessing-safety-and-efficacy-of-drug-candidates-alone-and-in-combination-with-medical-devices-the-case-study-of-spinalontm
#19
Pierre A Guertin
The aim of this review is to describe the rationale and main underlying reasons for undertaking, during clinical development, the study of drug candidates used separately and/or in combination with other technologies. To ease comprehension, reference will be made to the case of SpinalonTM, a new fixed-dose combination (FDC) product composed of levodopa/carbidopa/buspirone. This drug is capable of triggering, within minutes after a single administration orally, 45 minute- episodes of basic involuntary 'reflex' walking in paraplegic animals...
December 7, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27922541/effects-of-the-5-ht1a-receptor-agonists-buspirone-and-8-oh-dpat-on-pupil-size-in-common-marmosets
#20
Manato Kotani, Naoko Urushino, Itaru Natsutani, Yuji Ogi, Kazuhito Ikeda
As pupil size is affected by psychotropic drugs in all mammals, it has been used as a well-established clinical indicator for the preclinical and clinical development of novel drugs. It has been reported that activation of the serotonin (5-HT)1A receptor differently affects pupil response in rodents (mydriasis) and humans (miosis). Thus, it is important to establish a quantitative system for measuring pupil size using other species, such as nonhuman primates. Common marmosets have recently attracted a great deal of attention as suitable experimental animals in the psychoneurological field because of handling ease compared with other nonhuman primates and the requirement for small amounts of test drugs...
June 2017: Behavioural Pharmacology
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