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https://www.readbyqxmd.com/read/29792735/hip-fracture-in-the-setting-of-limited-life-expectancy-the-importance-of-considering-goals-of-care-and-prognosis
#1
C Bree Johnston, Amanda Holleran, Thuan Ong, Ursula McVeigh, Elizabeth Ames
IMPORTANCE: Many older patients with a limited life expectancy experience fragility fracture of the hip, and this event is associated with increased risk of premature mortality, functional decline, and institutionalization. The treating team, in collaboration with patients and their families, must determine whether a surgical or conservative approach is in the patient's best interest when a patient has limited life expectancy. OBSERVATION: Goals of care discussions appear to be rare in the setting of fragility fracture...
May 24, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29792514/a-flow-procedure-for-linearization-of-genome-sequence-graphs
#2
David Haussler, Maciej Smuga-Otto, Jordan M Eizenga, Benedict Paten, Adam M Novak, Sergei Nikitin, Maria Zueva, Dmitrii Miagkov
Efforts to incorporate human genetic variation into the reference human genome have converged on the idea of a graph representation of genetic variation within a species, a genome sequence graph. A sequence graph represents a set of individual haploid reference genomes as paths in a single graph. When that set of reference genomes is sufficiently diverse, the sequence graph implicitly contains all frequent human genetic variations, including translocations, inversions, deletions, and insertions. In representing a set of genomes as a sequence graph, one encounters certain challenges...
May 24, 2018: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/29792456/teamwork-situated-in-multiteam-systems-key-lessons-learned-and-future-opportunities
#3
Marissa L Shuffler, Dorothy R Carter
Many important contexts requiring teamwork, including health care, space exploration, national defense, and scientific discovery, present important challenges that cannot be addressed by a single team working independently. Instead, the complex goals these contexts present often require effectively coordinated efforts of multiple specialized teams working together as a multiteam system (MTS). For almost 2 decades, researchers have endeavored to understand the novelties and nuances for teamwork and collaboration that ensue when teams operate together as "component teams" in these interdependent systems...
May 2018: American Psychologist
https://www.readbyqxmd.com/read/29792452/foundations-of-teamwork-and-collaboration
#4
James E Driskell, Eduardo Salas, Tripp Driskell
The term teamwork has graced countless motivational posters and office walls. However, although teamwork is often easy to observe, it is somewhat more difficult to describe and yet more difficult to produce. At a broad level, teamwork is the process through which team members collaborate to achieve task goals. Teamwork refers to the activities through which team inputs translate into team outputs such as team effectiveness and satisfaction. In this article, we describe foundational research underlying current research on teamwork...
May 2018: American Psychologist
https://www.readbyqxmd.com/read/29792161/a-website-to-identify-shared-genes-in-saccharomyces-cerevisiae-homozygous-deletion-library-screens
#5
Mark D Temple
BACKGROUND: The homozygous yeast deletion library includes approximately 4800 diploid strains each containing one deleted non-essential gene. Hundreds of publications have arisen through experimentation using this genome-wide biological resource. As part of this work over 677 genesets have been collated from these experiments representing the phenotypic responses of the library to a diverse set of chemical and physical challenges. DESCRIPTION: A website called the Saccharomyces cerevisiae Homozygous Deletion Library Tools (ScHo DeLiTo-96) has been developed with the primary goal of browsing and identifying genes shared between these responsive phenotypes (available at yeastdb...
May 23, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29792039/identifying-palliative-care-needs-among-older-adults-in-nonclinical-settings
#6
Elissa Kozlov, Anna Cai, Jo Anne Sirey, Angela Ghesquiere, M Carrington Reid
Though palliative care is appropriate for patients with serious illness at any stage of the illness and treatment process, the vast majority of palliative care is currently delivered in inpatient medical settings in the past month of life during an acute hospitalization. Palliative care can have maximal benefit to patients when it is integrated earlier in the illness trajectory. One possible way to increase earlier palliative care use is to screen for unmet palliative care needs in community settings. The goal of this study was to assess the rates of unmet palliative care needs in older adults who attend New York City-based senior centers...
January 1, 2018: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29791725/measuring-the-implementation-of-early-childhood-development-programs
#7
REVIEW
Frances E Aboud, Elizabeth L Prado
In this paper we describe ways to measure variables of interest when evaluating the implementation of a program to improve early childhood development (ECD). The variables apply to programs delivered to parents in group sessions and home or clinic visits, as well as in early group care for children. Measurements for four categories of variables are included: training and assessment of delivery agents and supervisors; program features such as quality of delivery, reach, and dosage; recipients' acceptance and enactment; and stakeholders' engagement...
May 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29791627/emergency-care-units-and-dimensions-of-accessibility-to-health-care-for-the-elderly
#8
Giovana Aparecida de Souza Scolari, Leidyani Karina Rissardo, Vanessa Denardi Antoniassi Baldissera, Lígia Carreira
OBJECTIVE: to understand the conception of the elderly and their caregivers about the accessibility to health mediated by the service in Emergency Care Units. Methodo: a qualitative study conducted with 25 elderly patients and caregivers at Emergency Care Units in a city of Paraná, using Grounded Theory as a methodological reference. RESULTS: According to the participants, the resources available in these services guarantee medical consultation and provide access to exams and medicines...
2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29791553/epidemiological-aspects-clinical-manifestations-and-prevention-of-pediatric-tuberculosis-from-the-perspective-of-the-end-tb-strategy
#9
Anna Cristina Calçada Carvalho, Claudete Aparecida Araújo Cardoso, Terezinha Miceli Martire, Giovanni Battista Migliori, Clemax Couto Sant'Anna
Tuberculosis continues to be a public health priority in many countries. In 2015, tuberculosis killed 1.4 million people, including 210,000 children. Despite the recent progress made in the control of tuberculosis in Brazil, it is still one of the countries with the highest tuberculosis burdens. In 2015, there were 69,000 reported cases of tuberculosis in Brazil and tuberculosis was the cause of 4,500 deaths in the country. In 2014, the World Health Organization approved the End TB Strategy, which set a target date of 2035 for meeting its goals of reducing the tuberculosis incidence by 90% and reducing the number of tuberculosis deaths by 95%...
April 2018: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29791132/ptml-model-of-chembl-data-for-dopamine-targets-docking-synthesis-and-assay-of-new-plg-peptidomimetics
#10
Joana Ferreira da Costa, David Silva, Olga Caamaño, José M Brea, Maria Isabel Loza, Cristian R Munteanu, Alejandro Pazos, Xerardo García-Mera, Humbert González-Díaz
Predicting Drug-Protein Interactions (DPIs) for target proteins involved in Dopamine pathways is very important goal in medicinal chemistry. We can tackle this problem using Molecular Docking or Machine Learning (ML) models for one specific protein. Unfortunately, these models fail to account for large and complex Big Data sets of preclinical assays reported in public databases. This includes multiple conditions of assay like different experimental parameters, biological assays, target proteins, cell lines, organism of the target, organism of assay, etc...
May 23, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29790631/allied-health-clinicians-using-translational-research-in-action-to-develop-a-reliable-stroke-audit-tool
#11
Philip Abery, Suzanne Kuys, Mary Lynch, Nancy Low Choy
OBJECTIVE: To design and establish reliability of a local stroke audit tool by engaging allied health clinicians within a privately funded hospital. METHODS: Design: Two-stage study involving a modified Delphi process to inform stroke audit tool development and inter-tester reliability. PARTICIPANTS: Allied health clinicians. INTERVENTIONS: A modified Delphi process to select stroke guideline recommendations for inclusion in the audit tool...
May 23, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29790574/investigations-on-velvet-regulatory-mutants-confirm-the-role-of-host-tissue-acidification-and-secretion-of-proteins-in-the-pathogenesis-of-botrytis-cinerea
#12
Nathalie Müller, Michaela Leroch, Julia Schumacher, David Zimmer, Anne Könnel, Klaus Klug, Thomas Leisen, David Scheuring, Frederik Sommer, Timo Mühlhaus, Michael Schroda, Matthias Hahn
The Botrytis cinerea VELVET complex regulates light-dependent development and virulence. The goal of this study was to identify common virulence defects of several VELVET mutants and to reveal their molecular basis. Growth, differentiation, physiology, gene expression and infection of fungal strains were analyzed, and quantitative comparisons of in planta transcriptomes and secretomes were performed. VELVET mutants showed reduced release of citric acid, the major acid secreted by the wild-type, whereas no significant role for oxalic acid was observed...
May 23, 2018: New Phytologist
https://www.readbyqxmd.com/read/29790394/speech-and-language-pathologists-perceptions-and-practises-of-communication-partner-training-to-support-children-s-communication-with-high-tech-speech-generating-devices
#13
Helena Tegler, Mia Pless, Monica Blom Johansson, Karin Sonnander
PURPOSE: This study examined speech and language pathologists' (SLPs') perceptions and practices of communication partner training with high-tech speech generating devices (SGDs). METHOD: Fifteen SLPs were recruited throughout Sweden. The SLPs answered a study-specific questionnaire on communication partner training in relation to communication partners to children with severe cerebral palsy and intellectual disability. The results were analysed with descriptive statistics (closed-ended questions, responses on Likert scales) and content analysis (open-ended question) using ICF-CY...
May 23, 2018: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29790393/assistive-technology-policy-a-position-paper-from-the-first-global-research-innovation-and-education-on-assistive-technology-great-summit
#14
Malcolm MacLachlan, David Banes, Diane Bell, Johan Borg, Brian Donnelly, Michael Fembek, Ritu Ghosh, Rosie Gowran, Emma Hannay, Diana Hiscock, Evert-Jan Hoogerwerf, Tracey Howe, Friedbert Kohler, Natasha Layton, Siobhán Long, Hasheem Mannan, Gubela Mji, Thomas Odera Ongolo, Katherine Perry, Cecilia Pettersson, Jessica Power, Vinicius Delgado Ramos, Lenka Slepičková, Emma Smith, Kiu Tay-Teo, Priscille Geiser, Hilary Hooks
Increased awareness, interest and use of assistive technology (AT) presents substantial opportunities for many citizens to become, or continue being, meaningful participants in society. However, there is a significant shortfall between the need for and provision of AT, and this is patterned by a range of social, demographic and structural factors. To seize the opportunity that assistive technology offers, regional, national and sub-national assistive technology policies are urgently required. This paper was developed for and through discussion at the Global Research, Innovation and Education on Assistive Technology (GREAT) Summit; organized under the auspices of the World Health Organization's Global Collaboration on Assistive Technology (GATE) program...
May 23, 2018: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29790181/spatial-semantics-cognition-and-their-interaction-a-comparative-study-of-spatial-categorization-in-english-and-korean
#15
Hongoak Yun, Soonja Choi
This study has two goals. First, we present much-needed empirical linguistic data and systematic analyses on the spatial semantic systems in English and Korean, two languages that have been extensively compared to date in the debate on spatial language and spatial cognition. We conduct our linguistic investigation comprehensively, encompassing the domains of tight- and loose-fit as well as containment and support relations. The current analysis reveals both cross-linguistic commonalities and differences: From a common set of spatial features, each language highlights a subset of those features for its principal categorization, and those primary features are importantly different between English and Korean: English speakers categorize events predominantly by containment and support relations (and do so with prepositions), whereas Korean speakers categorize them by tight-fit and loose-fit relations (and do so with verbs), with a further distinction of containment and support within the loose-fit relation...
May 22, 2018: Cognitive Science
https://www.readbyqxmd.com/read/29790135/-spiritual-care-of-patients-with-depression
#16
Chia-Chan Kao, Yu-Hua Lin
Spiritual care is a component of holistic care. Patients with depression often experience body-mind-spirit health problems and may suffer from spiritual crises, particularly during the acute stage of a diseases, due to low self-esteem, negative attitudes toward life goals, daily life issues, and beliefs caused by physical, psychological, and occupational dysfunctions. Nonetheless, psychical care is the main treatment for patients with depression. This paper focuses on patients with depression and addresses the concepts of spiritual needs and spiritual care, identifying the factors that influence spiritual needs, the essentials of spiritual intervention, and the health effects of spiritual intervention outcomes on patients with depression...
June 2018: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/29788261/behavior-change-techniques-used-in-digital-behavior-change-interventions-to-reduce-excessive-alcohol-consumption-a-meta-regression
#17
Claire V Garnett, David Crane, Jamie Brown, Eileen F S Kaner, Fiona R Beyer, Colin R Muirhead, Matthew Hickman, Emma Beard, James Redmore, Frank de Vocht, Susan Michie
Background: Digital behavior change interventions (DBCIs) appear to reduce alcohol consumption, but greater understanding is needed of their mechanisms of action. Purpose: To describe the behavior change techniques (BCTs) used in DBCIs and examine whether individual BCTs, the inclusion of more BCTs or more Control Theory congruent BCTs is associated with increased effectiveness. Methods: Forty-one randomized control trials were extracted from a Cochrane review of alcohol reduction DBCIs and coded for up to 93 BCTs using an established and reliable method...
May 18, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/29787593/improving-the-effectiveness-of-performance-feedback-by-considering-personality-traits-and-task-demands
#18
Victor Swift, Jordan B Peterson
Although performance feedback is widely employed as a means to improve motivation, the efficacy and reliability of performance feedback is often obscured by individual differences and situational variables. The joint role of these moderating variables remains unknown. Accordingly, we investigate how the motivational impact of feedback is moderated by personality and task-difficulty. Utilizing three samples (total N = 916), we explore how Big Five personality traits moderate the motivational impact of false positive and negative feedback on playful, neutral, and frustrating puzzle tasks, respectively...
2018: PloS One
https://www.readbyqxmd.com/read/29786469/estimation-versus-falsification-approaches-in-sport-and-exercise-science
#19
Michael Wilkinson, Edward M Winter
There has been a recent resurgence in debate about methods for statistical inference in science. The debate addresses statistical concepts and their impact on the value and meaning of analyses' outcomes. In contrast, philosophical underpinnings of approaches and the extent to which analytical tools match philosophical goals of the scientific method have received less attention. This short piece considers application of the scientific method to "what-is-the-influence-of x-on-y" type questions characteristic of sport and exercise science...
May 22, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29785279/mental-health-recovery-goal-setting-and-working-alliance-in-an-australian-community-managed-organisation
#20
Grenville Rose, Lorraine Smith
This article examines the relationships between goal setting and achievement, working alliance and recovery in an Australian mental health community-managed organisation. The study gathered data over a 14-month period after the introduction of routine outcome measures. Both goal achievement and the strength of the working alliance were shown to have a positive effect on the personal recovery of the clients in the study. Both working alliance and goal achievement are robustly supportive at whatever point a person is on in the recovery journey...
January 2018: Health Psychology Open
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