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Bupropion

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https://www.readbyqxmd.com/read/27900470/influence-of-the-selective-antagonist-of-the-nr2b-subunit-of-the-nmda-receptor-traxoprodil-on-the-antidepressant-like-activity-of-desipramine-paroxetine-milnacipran-and-bupropion-in-mice
#1
Weronika Stasiuk, Aleksandra Szopa, Anna Serefko, Elżbieta Wyska, Katarzyna Świąder, Jarosław Dudka, Piotr Wlaź, Ewa Poleszak
Pre-clinical and clinical studies indicated that a blockade of the NMDA receptor complex creates new opportunities for the treatment of affective disorders, including depression. The aim of the present study was to assess the influence of traxoprodil (10 mg/kg) on the activity of desipramine (10 mg/kg), paroxetine (0.5 mg/kg), milnacipran (1.25 mg/kg), and bupropion (10 mg/kg), each at sub-therapeutic doses. Moreover, brain levels of traxoprodil and tested agents were determined using HPLC. The obtained results were used to ascertain the nature of occurring interaction between traxoprodil and studied antidepressants...
November 29, 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27893843/comparative-effectiveness-of-smoking-cessation-medications-a-national-prospective-cohort-from-taiwan
#2
Po-Yin Chang, Po-Ching Lo, Hui-Chin Chang, Kuang-Chieh Hsueh, Yi-Wen Tsai
BACKGROUND AND OBJECTIVE: Relative effectiveness of smoking cessation medications-varenicline, bupropion and nicotine replacement therapy (NRT)-remains unclear among smokers in real-world settings. Evidence in females and smokers with light/moderate nicotine dependence is particularly insufficient. This study compared the effectiveness of varenicline, bupropion or NRT gum relative to NRT patch, in achieving abstinence among recent quitters. METHODS: In a national smoking cessation program in Taiwan (2012-2015), a cohort of 11,968 participants received varenicline (n = 5,052), bupropion (n = 823), NRT gum (n = 1944) or NRT patch (n = 4,149)...
2016: PloS One
https://www.readbyqxmd.com/read/27890648/bupropion-sustained-release-for-pregnant-smokers-a-randomized-placebo-controlled-trial
#3
Tatiana N Nanovskaya, Cheryl Oncken, Valentina M Fokina, Richard S Feinn, Shannon M Clark, Holly West, Sunil K Jain, Mahmoud S Ahmed, Gary D V Hankins
BACKGROUND: Bupropion is used to treat depression during pregnancy. However, its usefulness as a smoking cessation aid for pregnant women is not fully known. OBJECTIVE: To evaluate the preliminary efficacy of bupropion sustained-release for smoking cessation during pregnancy. STUDY DESIGN: We conducted a randomized, prospective, double-blind, placebo-controlled, pilot trial. Pregnant women who smoked daily received individualized behavior counseling and were randomly assigned to a 12-week, twice-a-day treatment with 150 mg bupropion sustained-release or placebo...
November 24, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27889497/in-vivo-effect-of-borneol-on-rat-hepatic-cyp2b-expression-and-activity
#4
Jing-Ya Chen, Xiang-Tao Huang, Jun-Jun Wang, Yong Chen
CYP2B subfamily accounts for 2-10% of total hepatic CYP450 enzymes and participate in the metabolism of around 8% of clinical drugs. Borneol has been widely used in traditional Chinese medicine for thousands of years. There are many studies about borneol-induced promoting penetration role for a number of drugs through various physiologic barriers, whereas there is no report involved the effect of borneol on hepatic CYP2B. The present work studied the in vivo effect of borneol on the expression and activity of rat hepatic CYP2B...
November 23, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27882460/development-of-a-specific-substrate-inhibitor-panel-liver-on-a-chip-for-evaluation-of-cytochrome-p450-activity
#5
A A Zakhariants, O A Burmistrova, M Y Shkurnikov, A A Poloznikov, D A Sakharov
We developed a cytochrome P450 substrate-inhibitor panel for preclinical in vitro evaluation of drugs in a 3D histotypical microfluidic cell model of human liver (liver-on-a-chip technology). The concentrations of substrates and inhibitors were optimized to ensure reliable detection of the principal metabolites by HPLC-mass-spectroscopy. The selected specific substrate-inhibitor pairs, namely bupropion/2-phenyl-2-(1-piperidinyl)propane) for evaluation of CYP2B6B activity, tolbutamide/sulfaphenazole for CYP2C9, omeprazole/(+)-N-benzylnirvanol for CYP2C19, and testosterone/ketoconazole for CYP3A4, enable reliable evaluation of the drug metabolism pathway...
November 23, 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27876104/a-cohort-study-of-unstable-overdose-patients-treated-with-intravenous-lipid-emulsion-therapy
#6
Shazma Mithani, Kathryn Dong, Ashlea Wilmott, Heather Podmoroff, Nadim Lalani, Rhonda J Rosychuk, Ryan Chuang, Mark C Yarema
OBJECTIVES: Intravenous lipid emulsion (ILE) has been used increasingly over the last decade for a range of drug overdoses. Although the use of ILE in local anesthetic toxicity (LAST) is well established, the hemodynamic effectiveness of ILE in non-LAST poisonings is still unclear. Thus, the primary objective of this study was to examine a cohort of poisoned patients in whom ILE was administered. METHODS: Consecutive patients were identified by calls to a regional poison center from May 1, 2012 to May 30, 2014...
November 23, 2016: CJEM
https://www.readbyqxmd.com/read/27862184/serum-sickness-like-drug-reaction-two-cases-with-a-neutrophilic-urticarial-pattern
#7
Cuong V Nguyen, Daniel D Miller
The diagnosis of serum sickness-like reaction (SSLR) is typically based on clinical findings. Histopathologic examination is often deferred, as these eruptions commonly present in young children, and often to primary care providers. A Pubmed literature search revealed only 5 existing cases of SSLR with described cutaneous histopathologic features. We report two cases of serum sickness-like reaction, one each to bupropion and cefazolin. Skin biopsy findings in both cases demonstrated a neutrophil-predominant urticarial pattern resembling neutrophilic urticaria or neutrophilic urticarial dermatosis...
November 10, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27862160/in-vitro-and-pbpk-based-assessment-of-drug-drug-interaction-potential-of-canagliflozin
#8
Rao N V S Mamidi, Shannon Dallas, Carlo Sensenhauser, Heng Keang Lim, Ellen Scheers, Peter Verboven, Filip Cuyckens, Laurent Leclercq, David C Evans, Michael F Kelley, Mark D Johnson, Jan Snoeys
AIMS: Canagliflozin is a recently approved drug for use in the treatment of type 2 diabetes. The potential for canagliflozin to cause clinical drug-drug interactions (DDIs) was assessed. METHODS: DDI potential of canagliflozin was investigated using in vitro test systems containing drug metabolizing enzymes or transporters. Basic predictive approaches were applied to determine potential interaction in vivo. A physiologically-based pharmacokinetic (PBPK) model was developed and clinical DDI simulations were performed to determine the likelihood of CYP inhibition by canagliflozin...
November 11, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27851994/pregnancy-outcomes-after-maternal-varenicline-use-analysis-of-surveillance-data-collected-by-the-european-network-of-teratology-information-services
#9
J L Richardson, S Stephens, L M Yates, O Diav-Citrin, J Arnon, D Beghin, A Kayser, D Kennedy, D Cupitt, B Te Winkel, M Peltonen, Y C Kaplan, S H L Thomas
: Varenicline is a smoking cessation aid for which limited data exist concerning safety during human pregnancy. This multicentre prospective observational comparative cohort study was undertaken using surveillance data collected by the European Network of Teratology Information Services. The study sample consisted of 89 varenicline exposed pregnancies and two matched comparator groups; 267 non-teratogen exposed (NTE) controls and 78 exposed to nicotine replacement therapy or bupropion (NRT/B) for smoking cessation...
November 13, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27851687/determination-of-antidepressants-in-hair-via-uhplc-ms-ms-as-a-complementary-informative-tool-for-clinical-and-forensic-toxicological-assessments
#10
María Del Mar Ramírez Fernández, Sarah M R Wille, Virginia Hill, Nele Samyn
BACKGROUND: Hair analysis is a complementary approach for the detection of antidepressants (ADs) in clinical and forensic schemes because it yields a picture of long-term exposure over a time window depending on the length of the hair. METHODS: A fast and sensitive ultra-high performance liquid chromatography tandem mass spectrometry method using a BEH C18 column with a mobile phase consisting of ammonium acetate/acetonitrile was developed and validated according to international guidelines for the simultaneous analysis of 24 ADs in hair...
December 2016: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/27851477/1842-bupropion-overdose-presenting-with-serotonin-syndrome-a-case-report
#11
Sandhya Samavedam, Joshua Fenske, Sumedh Hoskote
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27845484/smoking-cessation-practice-among-family-doctors-in-lithuania-a-survey
#12
R Everatt, E Zolubiene, M C Grassi
OBJECTIVES: Relatively low proportion of ex-smokers and high rates of smoking-related diseases are estimated in Lithuania. The aim of this survey was to assess the extent of smoking cessation assistance among family doctors in Lithuania, and to identify factors associated with cessation interventions. MATERIALS AND METHODS: Data were collected using a questionnaire addressing family doctors' cessation assistance practice; knowledge of smoking epidemiology and health effects; knowledge of cessation assistance guidelines; smoking status; and attendance on Courses/Conferences on Smoking and smoking cessation Assistance (CCSA)...
September 2016: La Clinica Terapeutica
https://www.readbyqxmd.com/read/27836670/in-vitro-to-in-vivo-extrapolation-of-the-complex-drug-drug-interaction-of-bupropion-and-its-metabolites-with-cyp2d6-simultaneous-reversible-inhibition-and-cyp2d6-downregulation
#13
Jennifer E Sager, Sasmita Tripathy, Lauren Sl Price, Abhinav Nath, Justine Chang, Alyssa Stephenson-Famy, Nina Isoherranen
Bupropion is a widely used antidepressant and smoking cessation aid and a strong inhibitor of CYP2D6 in vivo. Bupropion is administered as a racemic mixture of R- and S-bupropion and has stereoselective pharmacokinetics. Four primary metabolites of bupropion, threo- and erythrohydrobupropion and R,R- and S,S-OH-bupropion, circulate at higher concentrations than the parent drug and are believed to contribute to the efficacy and side effects of bupropion as well as to the CYP2D6 inhibition. However, bupropion and its metabolites are only weak inhibitors of CYP2D6 in vitro, and the magnitude of the in vivo drug-drug interactions (DDI) caused by bupropion cannot be explained by the in vitro data even when CYP2D6 inhibition by the metabolites is accounted for...
November 8, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27833231/acute-dystonia-after-single-dose-of-bupropion
#14
Forouzan Elyasi, Elham Mahtiyan
Bupropion is an antidepressant that is effective in the treatment of major depressive disorders, smoking cessation, and sexual side effects of selective serotonin reuptake inhibitors. Acute dystonia is characterized by prolonged muscle contraction often represented by spasms of the head and neck muscles as well as occasional jaw clenching and temporomandibular joint syndrome. Although it is believed that dystonia is the result of an abnormality of the basal ganglia, its pathophysiology is still unclear. A few cases of dystonia resulting from bupropion have been reported in prior research papers...
September 2016: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/27817750/l-tetrahydropalmatine-reduces-nicotine-self-administration-and-reinstatement-in-rats
#15
Shamia L Faison, Charles W Schindler, Steven R Goldberg, Jia Bei Wang
BACKGROUND: The negative consequences of nicotine use are well known and documented, however, abstaining from nicotine use and achieving abstinence poses a major challenge for the majority of nicotine users trying to quit. l-Tetrahydropalmatine (l-THP), a compound extracted from the Chinese herb Corydalis, displayed utility in the treatment of cocaine and heroin addiction via reduction of drug-intake and relapse. The present study examined the effects of l-THP on abuse-related effects of nicotine...
November 7, 2016: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27816035/predictors-of-medication-adherence-and-smoking-cessation-among-smokers-under-community-corrections-supervision
#16
Karen L Cropsey, C Brendan Clark, Erin N Stevens, Samantha Schiavon, Adrienne C Lahti, Peter S Hendricks
INTRODUCTION: Individuals in the U.S. criminal justice system now represent over 12% of all current U.S. smokers. With smoking banned in most U.S. jails and prisons, the cessation focus for this population has shifted to individuals who are under community correction supervision (e.g., probation, parole). The aim of this study was to examine predictors of successful smoking cessation among criminal justice individuals supervised in the community. METHODS: Five hundred participants under community corrections supervision were randomized to receive either four sessions of smoking cessation counseling or no counseling in conjunction with 12weeks of bupropion treatment plus brief physician advice to quit...
October 23, 2016: Addictive Behaviors
https://www.readbyqxmd.com/read/27813651/a-systematic-review-of-the-use-of-bupropion-for-attention-deficit-hyperactivity-disorder-in-children-and-adolescents
#17
Qin Xiang Ng
INTRODUCTION: Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent neuropsychiatric disorders of childhood and adolescence. Stimulants are usually the first choice of drug; however, as many as 20% of patients do not respond to them. Stimulants may also worsen comorbid sleep, mood, and anxiety disorders, and they are associated with problems of misuse and diversion. Bupropion, a dopamine and norepinephrine reuptake inhibitor, is a promising nonstimulant alternative with reports of positive outcomes for ADHD management in both adolescent and adult populations...
November 4, 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/27793241/seizure-due-to-multiple-drugs-intoxication-a-case-report
#18
Handan Gulec, Munire Babayigit, Aysun Kurtay, Mehmet Sahap, Fatma Ulus, Zehra Tutal, Eyup Horasanli
The mechanism of the antidepressant effect of bupropion is not fully understood. Besides, using it in the treatment of depression, it is found to be effective in reducing withdrawal symptoms due to smoking cessation. A 28-year-old female patient with a history of depression was admitted to emergency department an hour after ingestion of bupropion, quetiapine, and levothyroxine in high doses to commit suicide. While accepting her into the Intensive Care Unit, she was awake, alert, disoriented and agitated. After 2h, the patient had a generalized tonic-clonic seizure...
November 2016: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/27788407/determination-of-clozapine-and-five-antidepressants-in-human-plasma-serum-and-whole-blood-by-gas-chromatography-mass-spectrometry-a-simple-tool-for-clinical-and-postmortem-toxicological-analysis
#19
Vassiliki A Boumba, George Rallis, Petros Petrikis, Theodore Vougiouklakis, Venetsanos Mavreas
In this study, we describe a simple and rapid method for the determination of the antipsychotic drug clozapine and five commonly co-administered antidepressants - bupropion, mirtazapine, sertraline, clomipramine and citalopram - in serum, plasma and whole blood. Sample preparation includes solid phase extraction of analytes and determination of drug concentrations by gas chromatography-mass spectrometry without any derivatization steps. The method was fully validated according to international criteria and can be successfully applied for routine analyses...
October 21, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27784123/-cost-effectiveness-of-pharmacological-smoking-cessation-therapies-a-systematic-literature-review
#20
I Aumann, K Rozanski, K Damm, J-M Graf von der Schulenburg
Aim of the Study: Through the promotion of smoking cessation premature mortality can be prevented. Therefore it is necessary to provide effective and cost-effective smoking cessation interventions. In Germany the cost of pharmacological smoking cessation measures are not yet reimbursed by the statutory health insurance. The aim of this study is to present the evidence on the cost-effectiveness of already approved pharmacological smoking cessation therapies and to evaluate their quality. Method: A systematic literature research was conducted in the databases by DIMDI (Medline, Embase, etc...
October 2016: Das Gesundheitswesen
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