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Andrew V Stachulski, Karl Swift, Mark Cooper, Stephen Reynolds, Daniel Norton, Steven D Slonecker, Jean-François Rossignol
Thiazolides are polypharmacology agents with at least three mechanisms of action against a broad spectrum of parasites, bacteria and viruses. In respiratory viruses they inhibit the replication of orthomyxoviridae and paramyxoviridae at a post-translational level. Nitazoxanide 1a, the prototype thiazolide, was originally developed as an antiparasitic agent and later repurposed for the treatment of viral respiratory infections. The second generation thiazolides following nitazoxanide, such as the 5-chloro analogue RM-5038 2a, are also broad-spectrum antiviral agents as we have reported...
September 26, 2016: European Journal of Medicinal Chemistry
Anamarija M Perry, Jacques Diebold, Bharat N Nathwani, Kenneth A MacLennan, Hans K Müller-Hermelink, Martin Bast, Eugene Boilesen, James O Armitage, Dennis D Weisenburger
The distribution of non-Hodgkin lymphoma subtypes varies around the world, but a large systematic comparative study has never been done. In this study, we evaluated the clinical features and relative frequencies of non-Hodgkin lymphoma subtypes in five developing regions of the world and compared the findings to the developed world. Five expert hematopathologists classified 4848 consecutive cases of lymphoma from 27 centers in 25 countries using the World Health Organization classification and 4539 (93.6%) were confirmed to be non-Hodgkin lymphoma, with a significantly greater number of males in the developing regions compared to the developed world (p<0...
June 27, 2016: Haematologica
Daria Trabattoni, Federica Gnudi, Salomè V Ibba, Irma Saulle, Simone Agostini, Michela Masetti, Mara Biasin, Jean-Francois Rossignol, Mario Clerici
Nitazoxanide (Alinia(®), NTZ) and tizoxanide (TIZ), its active circulating metabolite, belong to a class of agents known as thiazolides (TZD) endowed with broad anti-infective activities. TIZ and RM-4848, the active metabolite of RM-5038, were shown to stimulate innate immunity in vitro. Because natural resistance to HIV-1 infection in HIV-exposed seronegative (HESN) individuals is suggested to be associated with strong innate immune responses, we verified whether TIZ and RM-4848 could reduce the in vitro infectiousness of HIV-1...
2016: Scientific Reports
Marc A Ellsworth, Mikhail Dziadzko, John C O'Horo, Ann M Farrell, Jiajie Zhang, Vitaly Herasevich
OBJECTIVE: In this systematic review, we aimed to evaluate methodological and reporting trends present in the current literature by investigating published usability studies of electronic health records (EHRs). METHODS: A literature search was conducted for articles published through January 2015 using MEDLINE (Ovid), EMBASE, Scopus, and Web of Science, supplemented by citation and reference list reviews. Studies were included if they tested the usability of hospital and clinic EHR systems in the inpatient, outpatient, emergency department, or operating room setting...
April 23, 2016: Journal of the American Medical Informatics Association: JAMIA
Quang Duy Pham, David P Wilson, Thuong Vu Nguyen, Nhan Thi Do, Lien Xuan Truong, Long Thanh Nguyen, Lei Zhang
OBJECTIVES: The objective of this study was to investigate the potential epidemiological impact of viral load (VL) monitoring and its cost-effectiveness in Vietnam, where transmitted HIV drug resistance (TDR) prevalence has increased from <5% to 5%-15% in the past decade. METHODS: Using a population-based mathematical model driven by data from Vietnam, we simulated scenarios of various combinations of VL testing coverage, VL thresholds for second-line ART initiation and availability of HIV drug-resistance tests...
May 2016: Journal of Antimicrobial Chemotherapy
Dirk Timmerman, Ben Van Calster, Antonia Testa, Luca Savelli, Daniela Fischerova, Wouter Froyman, Laure Wynants, Caroline Van Holsbeke, Elisabeth Epstein, Dorella Franchi, Jeroen Kaijser, Artur Czekierdowski, Stefano Guerriero, Robert Fruscio, Francesco P G Leone, Alberto Rossi, Chiara Landolfo, Ignace Vergote, Tom Bourne, Lil Valentin
BACKGROUND: Accurate methods to preoperatively characterize adnexal tumors are pivotal for optimal patient management. A recent metaanalysis concluded that the International Ovarian Tumor Analysis algorithms such as the Simple Rules are the best approaches to preoperatively classify adnexal masses as benign or malignant. OBJECTIVE: We sought to develop and validate a model to predict the risk of malignancy in adnexal masses using the ultrasound features in the Simple Rules...
April 2016: American Journal of Obstetrics and Gynecology
Andrew G Nicholson, Kari Chansky, John Crowley, Ricardo Beyruti, Kaoru Kubota, Andrew Turrisi, Wilfried E E Eberhardt, Jan van Meerbeeck, Ramón Rami-Porta
INTRODUCTION: Small cell lung cancer (SCLC) is commonly classified as either limited or extensive, but the Union for International Cancer Control TNM Classification of Malignant Tumours seventh edition (2009) recommended tumor, node, and metastasis (TNM) staging based on analysis of the International Association for the Study of Lung Cancer (IASLC) database. METHODS: Survival analyses were performed for clinically and pathologically staged patients presenting with SCLC from 1999 through 2010...
March 2016: Journal of Thoracic Oncology
Jason G Andrade, Denis Roy, D George Wyse, Jean-Claude Tardif, Mario Talajic, Hugues Leduc, Julia-Cadrin Tourigny, Azadeh Shohoudi, Marc Dubuc, Léna Rivard, Peter G Guerra, Bernard Thibault, Katia Dyrda, Laurent Macle, Paul Khairy
BACKGROUND: An elevated resting heart rate has been associated with adverse cardiovascular outcomes. Its prognostic value has not specifically been examined in patients with atrial fibrillation. OBJECTIVE: The purpose of this study was to assess the relationship between resting heart rate measured in sinus rhythm and in atrial fibrillation and subsequent hospitalizations and death. METHODS: An analysis of individual patient-level data from subjects enrolled in the AFFIRM and AF-CHF trials was conducted to determine the impact of resting heart rate on hospitalizations and mortality...
January 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Sultan Ayoub Meo, Asim Hassan, Mansoor Aqil, Adnan Mahmood Usmani
BACKGROUND: Medical education is an essential domain to produce physicians with high standards of medical knowledge, skills and professionalism in medical practice. This study aimed to investigate the research progress and prospects of GCC countries in medical education during the period 1996-2013. METHODS: In this study, the research papers published in various global scientific journals during the period 1996-2013 were accessed. We recorded the total number of research documents having an affiliation with GCC Countries including Saudi Arabia, Bahrain, Kuwait, Qatar, United Arab Emirates and Oman...
2015: BMC Medical Education
R Schmidt, D Richter, A Sender, K Geue
Over the last decade, fertility-related issues have come to the fore of clinical oncology. The majority of research though has focused on a medical perspective without considering reproductive motivations that influence decisions on fertility-preserving options. In order to identify specific parenthood motivations in young survivors of various types of cancer, a systematic review of the literature was conducted. Relevant literature was searched manually and using databases (Medline/PubMed, PsycInfo). Of 4848 articles retrieved, 20 studies met a priori defined inclusion criteria...
January 2016: European Journal of Cancer Care
Sami Akbulut, Sezai Yilmaz
Since the first successful liver transplantation by Starzl et al. in 1967, liver transplantation has become the standard therapy for many liver diseases, mainly chronic liver disease. Most liver transplantations performed in Europe and North America utilize deceased donors while a considerable portion of organ requirements is supplied by living donors in Asian countries including Turkey. The actual history of solid organ transplantation in Turkey began with the pioneering work of Dr. Haberal in collaboration with Thomaz E...
July 2015: Transplantation Reviews
Andre C Kalil, Trevor C Van Schooneveld, Paul D Fey, Mark E Rupp
IMPORTANCE: Staphylococcus aureus bacteremia (SAB) is a worldwide problem. It is unclear whether higher-vancomycin minimum inhibitory concentration (MIC) is associated with mortality. This potential association has direct consequences for patients and public health. DATA SOURCES: PubMed, Embase, the Cochrane Library, Evidence-based Medicine BMJ, and the American College of Physicians Journal Club were searched from inception through April 2014. STUDY SELECTION: Studies reporting mortality and vancomycin MIC in patients with SAB were included...
October 15, 2014: JAMA: the Journal of the American Medical Association
J Maddock, A Cavadino, C Power, E Hyppönen
Both high and low vitamin D statuses have been associated with lower memory function. Apolipoprotein E (APOE) ɛ4 alleles have been associated with reduced memory function, and separately with higher vitamin D concentrations. This report aims to examine if the presence of APOE ɛ4 alleles contributes to the relationship between vitamin D and memory function. A total of 4848 (46% female) participants from the 1958 British birth cohort had information on APOE genotypes and completed memory tests at 50 years, where 4644 also had 25-hydroxyvitamin D (25(OH)D) concentrations measured at 45 years...
April 2015: European Journal of Clinical Nutrition
Ghenet Besera, Amira Roess
OBJECTIVE: To investigate the relationship between women's autonomy and attitudes toward female genital cutting (FGC) and having a daughter with FGC in Eritrea. METHODS: Data from a nationally representative sample of 8754 women aged between 15 and 49 years from the 2002 Eritrea Demographic and Health Survey were analyzed. Multivariate logistic regression was used to determine significant predictors of the practice of and attitudes toward FGC, including women's autonomy...
September 2014: International Journal of Gynaecology and Obstetrics
Seri Jeong, Sang-Guk Lee, Yoonjung Kim, Jeong Rae Park, Jeong-Ho Kim
OBJECTIVES: Polyethylene glycol-electrolyte lavage solutions (PEG-ELSs) and sodium phosphate formulations (NaPs) are two major colon cleansing laxatives used in preparation for endoscopic examinations of the gastrointestinal tract. PEG-ELSs are osmotically balanced preparations, whereas NaPs are hyperosmotic purgatives. This study aimed to evaluate the effects of these two laxatives on routine chemistry tests. DESIGN AND METHODS: We retrospectively reviewed 9366 clinical records of patients who had health checkups with or without colonoscopy from July 2010 to June 2011...
August 2014: Clinical Biochemistry
Chan Shen, Ya-Chen Tina Shih, Ying Xu, James C Yao
BACKGROUND: Octreotide long-acting repeatable (LAR) is indicated for the treatment of carcinoid syndrome and diarrhea related to VIPoma, and may delay tumor growth in patients with neuroendocrine tumors (NETs). To the authors' knowledge, the pattern of octreotide LAR use in clinical practice and its impact on survival outcomes has not been well documented. METHODS: Using the Surveillance, Epidemiology, and End Results (SEER)-Medicare database, the authors identified patients with NET aged ≥ 65 years who were diagnosed between July 1999 and December 2007...
July 1, 2014: Cancer
Sylvia van Beugen, Maaike Ferwerda, Dane Hoeve, Maroeska M Rovers, Saskia Spillekom-van Koulil, Henriët van Middendorp, Andrea Wm Evers
BACKGROUND: Patients with chronic somatic conditions face unique challenges accessing mental health care outside of their homes due to symptoms and physical limitations. Internet-based cognitive behavioral therapy (ICBT) has shown to be effective for various psychological conditions. The increasing number of recent trials need to be systematically evaluated and quantitatively analyzed to determine whether ICBT is also effective for chronic somatic conditions and to gain insight into the types of problems that could be targeted...
2014: Journal of Medical Internet Research
Vikram U Pandit, Sudhir S Arbuj, Uttam P Mulik, Bharat B Kale
6,13-Pentacenequinone (PQ), an intermediate for an organic semiconductor pentacene, was synthesized by single step solvent free solid state reaction at room temperature under ambient conditions which is hitherto unattempted. The phase purity has been confirmed by XRD and NMR. Optical study showed the absorption at 390 and 412 nm attributed to the π-π* and n-π* transitions, respectively. Cyclic voltammetry indicates the semiconducting nature of PQ having a band gap of 3 eV. The photoluminescence study revealed emissions at 408 and 432 nm...
April 1, 2014: Environmental Science & Technology
Dong Jin Suh, Han Chu Lee, Kwan Soo Byun, Mong Cho, Young Oh Kweon, Won Young Tak, Chae Yoon Chon, Kwang Cheol Koh, Young Sok Lee
BACKGROUND: Lamivudine resistance develops in up to 80% of patients with chronic hepatitis B (CHB) after 5 years of treatment. Cross-resistance between nucleoside/nucleotide analogues limits management options in these patients. To investigate the role of pegylated interferon-α2a as rescue therapy in these patients, the efficacy and safety of pegylated interferon-α2a between treatment-naive patients and lamivudine-resistant patients with hepatitis B e antigen (HBeAg)-positive CHB were compared...
2013: Antiviral Therapy
Mònica Guxens, Agnes M M Sonnenschein-van der Voort, Henning Tiemeier, Albert Hofman, Jordi Sunyer, Johan C de Jongste, Vincent W V Jaddoe, Liesbeth Duijts
BACKGROUND: Maternal psychological distress during pregnancy might affect fetal lung development and subsequently predispose children to childhood asthma. OBJECTIVE: We sought to assess the associations of maternal psychological distress during pregnancy with early childhood wheezing. METHODS: We performed a population-based prospective cohort study among 4848 children. We assessed maternal and paternal psychological distress at the second trimester of gestation and 3 years after delivery and maternal psychological distress at 2 and 6 months after delivery by using the Brief Symptom Inventory questionnaire...
January 2014: Journal of Allergy and Clinical Immunology
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