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https://www.readbyqxmd.com/read/29538246/vaginal-yolk-sac-tumors-our-experiences-and-results
#1
Zhen Yuan, Dongyan Cao, Jiaxin Yang, Shen Keng, Huifang Huang
OBJECTIVE: Vaginal yolk sac tumors (YSTs) are rare malignant germ cell tumors largely affecting children younger than 3 years. Because of their low incidence, there is no consensus regarding diagnosis and treatment. In this article, we describe the presentation, diagnosis, treatment, and outcomes of 16 patients with vaginal YSTs diagnosed and managed at our center. METHODS: Diagnoses of YST of the vagina were confirmed by 2 experienced pathologists. All patients were treated with bleomycin, etoposide, and cisplatin (PEB) combination chemotherapy alone...
March 14, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28939674/thrombolysis-in-postoperative-stroke
#2
MULTICENTER STUDY
Nicolas Voelkel, Nikolai Dominik Hubert, Roland Backhaus, Roman Ludwig Haberl, Gordian Jan Hubert
BACKGROUND AND PURPOSE: Intravenous thrombolysis (IVT) is beneficial in reducing disability in selected patients with acute ischemic stroke. There are numerous contraindications to IVT. One is recent surgery. The aim of this study was to analyze the safety of IVT in patients with postoperative stroke. METHODS: Data of consecutive IVT patients from the Telemedical Project for Integrative Stroke Care thrombolysis registry (February 2003 to October 2014; n=4848) were retrospectively searched for keywords indicating preceding surgery...
November 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28932446/crystal-structure-of-bis-n-2-hy-droxy-eth-yl-n-methyl-dithio-carbamato-%C3%AE%C2%BA-2-s-s-pyridine-zinc-ii-pyridine-monosolvate-and-its-n-ethyl-analogue
#3
Pavel Poplaukhin, Edward R T Tiekink
The common structural feature of the title compounds, [Zn(C4H8NOS2)2(C5H5N)]·C5H5N (I) and [Zn(C5H10NOS2)2(C5H5N)]·C5H5N (II), which differ by having di-thio-carbamate N-bound methyl (I) and ethyl (II) groups, is the coordination of each Zn(II) atom by two non-symmetrically chelating di-thio-carbamate ligands and by a pyridine ligand; in each case, the non-coordinating pyridine mol-ecule is connected to the Zn-containing mol-ecule via a (hy-droxy)O-H⋯N(pyridine) hydrogen bond. The resulting NS4 coordination geometry is closer to a square-pyramid than a trigonal bipyramid in the case of (I), but almost inter-mediate between the two extremes in (II)...
July 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28880552/novel-inhibitors-of-staphyloxanthin-virulence-factor-in-comparison-with-linezolid-and-vancomycin-versus-methicillin-resistant-linezolid-resistant-and-vancomycin-intermediate-staphylococcus-aureus-infections-in-vivo
#4
COMPARATIVE STUDY
Shuaishuai Ni, Hanwen Wei, Baoli Li, Feifei Chen, Yifu Liu, Wenhua Chen, Yixiang Xu, Xiaoxia Qiu, Xiaokang Li, Yanli Lu, Wenwen Liu, Linhao Hu, Dazheng Lin, Manjiong Wang, Xinyu Zheng, Fei Mao, Jin Zhu, Lefu Lan, Jian Li
Our previous work ( Wang et al. J. Med. Chem. 2016 , 59 , 4831 - 4848 ) revealed that effective benzocycloalkane-derived staphyloxanthin inhibitors against methicillin-resistant Staphylococcus aureus (S. aureus) infections were accompanied by poor water solubility and high hERG inhibition and dosages (preadministration). In this study, 92 chroman and coumaran derivatives as novel inhibitors have been addressed for overcoming deficiencies above. Derivatives 69 and 105 displayed excellent pigment inhibitory activities and low hERG inhibition, along with improvement of solubility by salt type selection...
October 12, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28641824/a-newly-discovered-manuscript-of-charles-t-jackson-md-history-of-the-patenting-of-the-application-of-sulphuric-ether-for-the-production-of-insensibility
#5
Rajesh P Haridas, George S Bause
In 2016, the Wood Library-Museum of Anesthesiology, Schaumburg, IL, acquired an unpublished 11-page manuscript written by Charles Thomas Jackson, MD, (1805-1880). The undated manuscript, now fully transcribed, provides Jackson's perspective of the first 6 weeks of the ether discovery, from early October 1846 to mid-November 1846. It chronicles Jackson's observations and discussions pertaining to United States Patent No. 4848, granted to him and William Thomas Green Morton, MD, (1819-1868). Jackson's manuscript did not yield new information on the discovery of surgical etherization or the subsequent dispute between him and Morton...
April 2017: Journal of Anesthesia History
https://www.readbyqxmd.com/read/28624059/exploring-regional-variability-in-utilization-of-antireflux-surgery-in-children
#6
Heather L Short, Wanzhe Zhu, Courtney McCracken, Curtis Travers, Lance A Waller, Mehul V Raval
BACKGROUND: There is significant variation surrounding the indications, surgical approaches, and outcomes for children undergoing antireflux procedures (ARPs) resulting in geographic variation of care. Our purpose was to quantify this geographic variation in the utilization of ARPs in children. METHODS: A cross-sectional analysis of the 2009 Kid's Inpatient Database was performed to identify patients with gastroesophageal reflux disease or associated diagnoses. Regional surgical utilization rates were determined, and a mixed effects model was used to identify factors associated with the use of ARPs...
June 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28451066/helicobacter-pylori-recurrence-after-eradication-in-latin-america-implications-for-gastric-cancer-prevention
#7
Juan E Corral, Robertino Mera, Corey W Dye, Douglas R Morgan
AIM: To estimate Helicobacter pylori (H. pylori) recurrence rate in Latin America, a region with a significant H. pylori prevalence and gastric cancer burden. METHODS: PubMed, LILACS, SciELO, Cochrane databases and abstracts from relevant meetings were reviewed. Information collected included: Participants' characteristics, recruitment strategy, diagnostic modality, treatment arms, follow-up and recurrence rates. Recurrence was calculated using 100-patients-year rates, and data were pooled using a random effects model...
April 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28445256/cost-effectiveness-analysis-of-ultrasonography-screening-for-nonalcoholic-fatty-liver-disease-in-metabolic-syndrome-patients
#8
Pochamana Phisalprapa, Siripen Supakankunti, Phunchai Charatcharoenwitthaya, Piyaporn Apisarnthanarak, Aphinya Charoensak, Chaiwat Washirasaksiri, Weerachai Srivanichakorn, Nathorn Chaiyakunapruk
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) can be diagnosed early by noninvasive ultrasonography; however, the cost-effectiveness of ultrasonography screening with intensive weight reduction program in metabolic syndrome patients is not clear. This study aims to estimate economic and clinical outcomes of ultrasonography in Thailand. METHODS: Cost-effectiveness analysis used decision tree and Markov models to estimate lifetime costs and health benefits from societal perspective, based on a cohort of 509 metabolic syndrome patients in Thailand...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28406147/transcriptome-analyses-of-differential-gene-expression-in-the-bursa-of-fabricius-between-silky-fowl-and-white-leghorn
#9
Deping Han, Yuanyuan Zhang, Jianfei Chen, Guoying Hua, Junying Li, Xuegong Deng, Xuemei Deng
Hyperpigmentation in Silky Fowl (SF) results in aberrant immune cell development. However, how melanocytes regulate B-cell proliferation in the bursa of Fabricius (BF) is unclear. To resolve this conundrum, we collected BFs from three-week-old SF and White Leghorn (WL) female chickens for RNA sequencing. The BF development was relatively weaker in SF than in WL. The transcriptome analyses identified 4848 differentially expressed genes, 326 long noncoding RNAs (lncRNAs), and 67 microRNAs in the BF of SF. The genes associated with melanogenesis was significantly higher, but that of the genes associated with the cytokine-cytokine receptor interactions and JAK-STAT signalling pathway was significantly lower in SF than in WL...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27888412/diabetes-screening-in-overweight-and-obese-children-and-adolescents-choosing-the-right-test
#10
MULTICENTER STUDY
Stefan Ehehalt, Susanna Wiegand, Antje Körner, Roland Schweizer, Klaus-Peter Liesenkötter, Carl-Joachim Partsch, Gunnar Blumenstock, Ulrike Spielau, Christian Denzer, Michael B Ranke, Andreas Neu, Gerhard Binder, Martin Wabitsch, Wieland Kiess, Thomas Reinehr
Type 2 diabetes can occur without any symptoms, and health problems associated with the disease are serious. Screening tests allowing an early diagnosis are desirable. However, optimal screening tests for diabetes in obese youth are discussed controversially. We performed an observational multicenter analysis including 4848 (2668 female) overweight and obese children aged 7 to 17 years without previously known diabetes. Using HbA1c and OGTT as diagnostic criteria, 2.4% (n = 115, 55 female) could be classified as having diabetes...
January 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27873429/low-association-between-fasting-and-ogtt-stimulated-glucose-levels-with-hba1c-in-overweight-children-and-adolescents
#11
Stefan Ehehalt, Susanna Wiegand, Antje Körner, Roland Schweizer, Klaus-Peter Liesenkötter, Carl-Joachim Partsch, Gunnar Blumenstock, Ulrike Spielau, Christian Denzer, Michael B Ranke, Andreas Neu, Gerhard Binder, Martin Wabitsch, Wieland Kiess, Thomas Reinehr
BACKGROUND: Diabetes and prediabetes are defined based on different methods such as fasting glucose, glucose at 2-hour in oral glucose tolerance test (OGTT), and glycated hemoglobin A1c (HbA1c). These parameters probably describe different deteriorations in glucose metabolism limiting the exchange between each other in definitions of diabetes. OBJECTIVE: To investigate the relationship between OGTT and HbA1c in overweight and obese children and adolescents living in Germany...
December 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/27814267/systolic-blood-pressure-on-admission-and-mortality-in-patients-hospitalized-with-acute-heart-failure-observations-from-the-gulf-acute-heart-failure-registry
#12
Jawad A Al-Lawati, Kadhim J Sulaiman, Ibrahim Al-Zakwani, Alawi A Alsheikh-Ali, Prashanth Panduranga, Khalid F Al-Habib, Jassim Al-Suwaidi, Wael Al-Mahmeed, Hussam Al-Faleh, Abdelfatah El-Asfar, Ahmed Al-Motarreb, Mustafa Ridha, Bassam Bulbanat, Mohammed Al-Jarallah, Nooshin Bazargani, Nidal Asaad, Haitham Amin
We investigated the role of systolic blood pressure (SBP) in relation to in-hospital and postdischarge mortality in patients admitted with acute heart failure (AHF). The SBP of 4848 patients aged ≥18 years admitted with AHF was categorized into 5 groups: ≤90, 91 to 119, 120 to 139, 140 to 161, and >161 mm Hg. After adjusting for several confounders, multivariate logistic regression models showed that admission SBP was a significant predictor of mortality among both patients with preserved left ventricular function (defined as left ventricular ejection fraction [LVEF] ≥40%) and patients with left ventricular dysfunction (LVEF <40%)...
October 7, 2016: Angiology
https://www.readbyqxmd.com/read/27750149/synthesis-and-pre-clinical-studies-of-new-amino-acid-ester-thiazolide-prodrugs
#13
Andrew V Stachulski, Karl Swift, Mark Cooper, Stephen Reynolds, Daniel Norton, Steven D Slonecker, Jean-François Rossignol
Thiazolides are polypharmacology agents with at least three mechanisms of action against a broad spectrum of parasites, bacteria and viruses. In respiratory viruses they inhibit the replication of orthomyxoviridae and paramyxoviridae at a post-translational level. Nitazoxanide 1a, the prototype thiazolide, was originally developed as an antiparasitic agent and later repurposed for the treatment of viral respiratory infections. The second generation thiazolides following nitazoxanide, such as the 5-chloro analogue RM-5038 2a, are also broad-spectrum antiviral agents as we have reported...
January 27, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27354024/non-hodgkin-lymphoma-in-the-developing-world-review-of-4539-cases-from-the-international-non-hodgkin-lymphoma-classification-project
#14
MULTICENTER STUDY
Anamarija M Perry, Jacques Diebold, Bharat N Nathwani, Kenneth A MacLennan, Hans K Müller-Hermelink, Martin Bast, Eugene Boilesen, James O Armitage, Dennis D Weisenburger
The distribution of non-Hodgkin lymphoma subtypes varies around the world, but a large systematic comparative study has never been done. In this study, we evaluated the clinical features and relative frequencies of non-Hodgkin lymphoma subtypes in five developing regions of the world and compared the findings to the developed world. Five expert hematopathologists classified 4848 consecutive cases of lymphoma from 26 centers in 24 countries using the World Health Organization classification, and 4539 (93.6%) were confirmed to be non-Hodgkin lymphoma, with a significantly greater number of males than females in the developing regions compared to the developed world (P<0...
October 2016: Haematologica
https://www.readbyqxmd.com/read/27250526/thiazolides-elicit-anti-viral-innate-immunity-and-reduce-hiv-replication
#15
Daria Trabattoni, Federica Gnudi, Salomè V Ibba, Irma Saulle, Simone Agostini, Michela Masetti, Mara Biasin, Jean-Francois Rossignol, Mario Clerici
Nitazoxanide (Alinia(®), NTZ) and tizoxanide (TIZ), its active circulating metabolite, belong to a class of agents known as thiazolides (TZD) endowed with broad anti-infective activities. TIZ and RM-4848, the active metabolite of RM-5038, were shown to stimulate innate immunity in vitro. Because natural resistance to HIV-1 infection in HIV-exposed seronegative (HESN) individuals is suggested to be associated with strong innate immune responses, we verified whether TIZ and RM-4848 could reduce the in vitro infectiousness of HIV-1...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27107451/an-appraisal-of-published-usability-evaluations-of-electronic-health-records-via-systematic-review
#16
REVIEW
Marc A Ellsworth, Mikhail Dziadzko, John C O'Horo, Ann M Farrell, Jiajie Zhang, Vitaly Herasevich
OBJECTIVE: In this systematic review, we aimed to evaluate methodological and reporting trends present in the current literature by investigating published usability studies of electronic health records (EHRs). METHODS: A literature search was conducted for articles published through January 2015 using MEDLINE (Ovid), EMBASE, Scopus, and Web of Science, supplemented by citation and reference list reviews. Studies were included if they tested the usability of hospital and clinic EHR systems in the inpatient, outpatient, emergency department, or operating room setting...
January 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/26869689/projecting-the-epidemiological-effect-cost-effectiveness-and-transmission-of-hiv-drug-resistance-in-vietnam-associated-with-viral-load-monitoring-strategies
#17
Quang Duy Pham, David P Wilson, Thuong Vu Nguyen, Nhan Thi Do, Lien Xuan Truong, Long Thanh Nguyen, Lei Zhang
OBJECTIVES: The objective of this study was to investigate the potential epidemiological impact of viral load (VL) monitoring and its cost-effectiveness in Vietnam, where transmitted HIV drug resistance (TDR) prevalence has increased from <5% to 5%-15% in the past decade. METHODS: Using a population-based mathematical model driven by data from Vietnam, we simulated scenarios of various combinations of VL testing coverage, VL thresholds for second-line ART initiation and availability of HIV drug-resistance tests...
May 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/26800772/predicting-the-risk-of-malignancy-in-adnexal-masses-based-on-the-simple-rules-from-the-international-ovarian-tumor-analysis-group
#18
MULTICENTER STUDY
Dirk Timmerman, Ben Van Calster, Antonia Testa, Luca Savelli, Daniela Fischerova, Wouter Froyman, Laure Wynants, Caroline Van Holsbeke, Elisabeth Epstein, Dorella Franchi, Jeroen Kaijser, Artur Czekierdowski, Stefano Guerriero, Robert Fruscio, Francesco P G Leone, Alberto Rossi, Chiara Landolfo, Ignace Vergote, Tom Bourne, Lil Valentin
BACKGROUND: Accurate methods to preoperatively characterize adnexal tumors are pivotal for optimal patient management. A recent metaanalysis concluded that the International Ovarian Tumor Analysis algorithms such as the Simple Rules are the best approaches to preoperatively classify adnexal masses as benign or malignant. OBJECTIVE: We sought to develop and validate a model to predict the risk of malignancy in adnexal masses using the ultrasound features in the Simple Rules...
April 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26723244/the-international-association-for-the-study-of-lung-cancer-lung-cancer-staging-project-proposals-for-the-revision-of-the-clinical-and-pathologic-staging-of-small-cell-lung-cancer-in-the-forthcoming-eighth-edition-of-the-tnm-classification-for-lung-cancer
#19
Andrew G Nicholson, Kari Chansky, John Crowley, Ricardo Beyruti, Kaoru Kubota, Andrew Turrisi, Wilfried E E Eberhardt, Jan van Meerbeeck, Ramón Rami-Porta
INTRODUCTION: Small cell lung cancer (SCLC) is commonly classified as either limited or extensive, but the Union for International Cancer Control TNM Classification of Malignant Tumours seventh edition (2009) recommended tumor, node, and metastasis (TNM) staging based on analysis of the International Association for the Study of Lung Cancer (IASLC) database. METHODS: Survival analyses were performed for clinically and pathologically staged patients presenting with SCLC from 1999 through 2010...
March 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/26299677/heart-rate-and-adverse-outcomes-in-patients-with-atrial-fibrillation-a-combined-affirm-and-af-chf-substudy
#20
RANDOMIZED CONTROLLED TRIAL
Jason G Andrade, Denis Roy, D George Wyse, Jean-Claude Tardif, Mario Talajic, Hugues Leduc, Julia-Cadrin Tourigny, Azadeh Shohoudi, Marc Dubuc, Léna Rivard, Peter G Guerra, Bernard Thibault, Katia Dyrda, Laurent Macle, Paul Khairy
BACKGROUND: An elevated resting heart rate has been associated with adverse cardiovascular outcomes. Its prognostic value has not specifically been examined in patients with atrial fibrillation. OBJECTIVE: The purpose of this study was to assess the relationship between resting heart rate measured in sinus rhythm and in atrial fibrillation and subsequent hospitalizations and death. METHODS: An analysis of individual patient-level data from subjects enrolled in the AFFIRM and AF-CHF trials was conducted to determine the impact of resting heart rate on hospitalizations and mortality...
January 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
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