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https://www.readbyqxmd.com/read/29652817/selenium-in-radiation-oncology-15-years-of-experiences-in-germany
#1
REVIEW
Ralph Muecke, Oliver Micke, Lutz Schomburg, Jens Buentzel, Klaus Kisters, Irenaeus A Adamietz
Introduction: Se measurement and supplementation in radiation oncology is a controversial issue. The German Working Group Trace Elements and Electrolytes in Oncology (AKTE) has conducted a number of studies on this issue, which are summarized in this review. Strategies have been tested and developed, aiming to stratify the patients with a potential need for supplemental Se and how best to monitor Se supplementation with respect to health effects and risks. Methods: We analyzed blood and tissue Se-levels of different tumor patients ( n = 512)...
April 13, 2018: Nutrients
https://www.readbyqxmd.com/read/29651875/is-severe-emphysema-as-defined-by-quantitative-ct-measurement-a-negative-risk-factor-of-radiation-pneumonitis
#2
Tatsuhiko Saito, Hidetsugu Nakayama, Takafumi Yamada, Sachica Shiraishi, Koichi Tokuuye
OBJECTIVES: To investigate whether patients with emphysema, as evaluated by quantitative CT image measurement, are at risk of developing radiation pneumonitis (RP) after radiotherapy for non-small cell lung cancer (NSCLC). METHODS: Between March 2011 and June 2015, 68 consecutive patients with stage INSCLC treated with a radiotherapy a dose of 75 Gy given in 30 fractions were enrolled. The median age was 79 years and there were 45 males and 23 females. The numbers of patients with T1 and T2 were 49 and 19, respectively...
April 13, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29651825/feasibility-of-using-optical-coherence-tomography-to-detect-acute-radiation-induced-esophageal-damage-in-small-animal-models
#3
Pouya Jelvehgaran, Daniel Martijn de Bruin, F Javier Salguero, Gerben Roelof Borst, Ji-Ying Song, Ton G van Leeuwen, Johannes F de Boer, Tanja Alderliesten, Marcel van Herk
Lung cancer survival is poor, and radiation therapy patients often suffer serious treatment side effects. The esophagus is particularly sensitive leading to acute radiation-induced esophageal damage (ARIED). We investigated the feasibility of optical coherence tomography (OCT) for minimally invasive imaging of the esophagus with high resolution (10  μm) to detect ARIED in mice. Thirty mice underwent cone-beam computed tomography imaging for initial setup assessment and dose planning followed by a single-dose delivery of 4...
April 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29651767/radiation-burden-and-associated-cancer-risk-for-a-typical-population-to-be-screened-for-lung-cancer-with-low-dose-ct-a-phantom-study
#4
Kostas Perisinakis, Ioannis Seimenis, Antonis Tzedakis, Apostolos Karantanas, John Damilakis
OBJECTIVES: To estimate (a) organ doses and organ-specific radiation-induced cancer risk from a single low-dose CT (LDCT) for lung cancer screening (LCS) and (b) the theoretical cumulative risk of radiation-induced cancer for a typical cohort to be subjected to repeated annual LCS LDCT. METHODS: Sex- and body size-specific organ dose data from scan projection radiography (SPR) and helical CT exposures involved in LCS 256-slice LDCT were determined using Monte Carlo methods...
April 12, 2018: European Radiology
https://www.readbyqxmd.com/read/29651598/geriatric-assessment-for-older-patients-with-non-small-cell-lung-cancer-daily-practice-of-centers-participating-in-the-nvalt25-eldapt-trial
#5
Elisabeth J M Driessen, Judith G M van Loon, Huub A Maas, Anne-Marie C Dingemans, Maryska L G Janssen-Heijnen
INTRODUCTION: Geriatric assessment (GA) for older patients with lung cancer could provide insight into vulnerability, cognitive impairment, and risk of toxicity. Discontinuation and complications of intensive treatment could potentially be prevented in vulnerable and frail patients. This study aimed to evaluate current clinical practice of GA for older patients with lung cancer in the Netherlands and identify potential hurdles for implementation. METHODS: Pulmonologists and radiation oncologists participating in the NVALT25-ELDAPT trial completed an online questionnaire regarding current practice of GA, added value of GA for treatment decision-making and logistic barriers for patients with non-small cell lung cancer...
April 12, 2018: Lung
https://www.readbyqxmd.com/read/29650895/-chemoradiotherapy-using-molecular-targeted-therapy
#6
Hiroaki Akamatsu
Instead of the combination treatment with cytotoxic chemotherapy and radiation therapy, molecular targeted drugs is testing in many clinical trials. Because unexpected adverse events were reported in the previous trials using molecular targeted drugs with radiotherapy, attention should be paid to this combination. In EGFR mutated lung cancer, gefitinib with radiotherapy is testing.
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650833/-a-case-of-local-recurrence-of-descending-colon-cancer-with-ileus-obstruction-and-lung-liver-and-brain-metastasis
#7
Ryouichi Tomita, Shigeru Fujisaki, Kenichi Sakurai, Takeo Azuhata, Yuko Takamoto
We report a 50-year-old man with local recurrence of descending colon cancer with ileus obstruction and brain metastasis, 2 years 6 months after initial resection due to perforation of descending colon cancer(Hartmann procedure, D2 lymph node resection, Stage II, tub2). He complained of left upper abdominal pain and abdominal fullness. He also complained of paresis of the right upper extremity and of experiencing convulsions 1 month before admission. He was diagnosed with local recurrence of descending colon cancer, based on findings of contrast radiography and the presence of colonic fiber...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29644155/stereotactic-body-radiation-therapy-for-pulmonary-oligometastases-arising-from-non-lung-primaries-in-patients-without-extrapulmonary-disease
#8
Michael J Dohopolski, Zachary Horne, David Clump, Steven A Burton, Dwight E Heron
Purpose Stereotactic body radiation therapy (SBRT) is increasingly used in the management of patients with oligometastatic cancers and is under prospective evaluation by the Radiation Therapy Oncology Group (RTOG). Here we report outcomes from a high-volume institution of patients treated with SBRT for pulmonary oligometastases. Materials and methods We conducted a retrospective review of 105 patients who had one to five pulmonary oligometastases (185 lesions) without extrapulmonary disease treated with SBRT from 2002-2014...
February 7, 2018: Curēus
https://www.readbyqxmd.com/read/29626227/effect-of-internal-contamination-with-tritiated-water-on-the-neoplastic-colonies-in-the-lungs-innate-anti-tumour-reactions-cytokine-profile-and-haematopoietic-system-in-radioresistant-and-radiosensitive-mice
#9
Ewa M Nowosielska, Aneta Cheda, Robert Zdanowski, Sławomir Lewicki, Bobby R Scott, Marek K Janiak
Tritium is a potentially significant source of internal radiation exposure which, at high levels, can be carcinogenic. We evaluated whether single intraperitoneal injection of BALB/c and C57BL/6 mice with tritiated water (HTO) leading to exposure to low (0.01 or 0.1 Gy) and intermediate (1.0 Gy) cumulative whole-body doses of β radiation is immunosuppressive, as judged by enhancement of artificial tumour metastases, functioning of NK lymphocytes and macrophages, circulating cytokine's levels, and numbers of bone marrow, spleen, and peripheral blood cells...
April 6, 2018: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/29626120/a-new-method-for-tumor-imaging-by-targeting-cancer-associated-fibroblasts
#10
Anastasia Loktev, Thomas Lindner, Walter Mier, Jürgen Debus, Annette Altmann, Dirk Jäger, Frederik Giesel, Clemens Kratochwil, Philippe Barthe, Christian Roumestand, Uwe Haberkorn
The tumor stroma, which accounts for a large part of the tumor mass, represents an attractive target for the delivery of diagnostic and therapeutic compounds. Here, the focus is notably on a subpopulation of stromal cells, known as cancer-associated fibroblasts (CAFs), which are present in more than 90% of epithelial carcinomas including pancreatic, colon and breast cancer. CAFs feature a high expression of fibroblast activation protein (FAP), which is not detectable in adult normal tissue but associated with a poor prognosis in cancer patients...
April 6, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29625898/palliative-thoracic-radiation-therapy-for-non-small-cell-lung-cancer-2018-update-of-an-american-society-for-radiation-oncology-astro-evidence-based-guideline
#11
Benjamin Moeller, Ehsan H Balagamwala, Aileen Chen, Kimberly M Creach, Giuseppe Giaccone, Matthew Koshy, Sandra Zaky, George Rodrigues
PURPOSE: To revise the recommendation on the use of concurrent chemotherapy (CC) with palliative thoracic external beam radiation therapy (EBRT) made in the original 2011 American Society for Radiation Oncology guideline on palliative thoracic radiation for lung cancer. METHODS AND MATERIALS: Based on a systematic PubMed search showing new evidence for this key question, the task force felt an update was merited. Guideline recommendations were created using a predefined consensus-building methodology supported by American Society for Radiation Oncology-approved tools for grading evidence quality and recommendation strength...
April 3, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29623584/dosimetry-study-of-18-f-fmiso-pet-ct-hypoxia-imaging-guidance-on-intensity-modulated-radiation-therapy-for-non-small-cell-lung-cancer
#12
H Li, D Xu, X Han, Q Ruan, X Zhang, Y Mi, M Dong, S Guo, Y Lin, B Wang, G Li
OBJECTIVES: This study was to evaluate the feasibility of simultaneous integrated boost on tumor hypoxia area by studying the dosimetric change of hypoxia imaging guidance on intensity-modulated radiation therapy for non-small cell lung cancer (NSCLC). METHODS: Five NSCLC patients with large hypoxic volume participated in this study. FDG PET/CT images were fused with CT localization images to delineate gross tumor volume. FMISO PET/CT images were fused with CT localization images to delineate hypoxic biological target volume (BTV) (tissue maximum ratio ≥ 1...
April 5, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29623466/is-tumor-volume-reduction-during-radiotherapy-prognostic-relevant-in-patients-with-stage-iii-non-small-cell-lung-cancer
#13
Khaled Elsayad, Laith Samhouri, Sergiu Scobioala, Uwe Haverkamp, Hans Theodor Eich
PURPOSE/OBJECTIVE(S): Lung cancer tumor volume reduction is common during radiation treatment (RT). The purpose of this study was to investigate tumor volume reduction ratio (VRR) and its correlation with outcomes in a cohort of patients with stage III non-small cell lung cancer (NSCLC) who underwent image-guided radiochemotherapy (RCTx). MATERIALS/METHODS: Fifty patients with NSCLC treated with fractionated RT at our institution between 2013 and 2017 were included...
April 5, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29622079/lung-cancer-posttreatment-imaging-radiation-therapy-and-imaging-findings
#14
REVIEW
Marcelo F Benveniste, James Welsh, Chitra Viswanathan, Girish S Shroff, Sonia L Betancourt Cuellar, Brett W Carter, Edith M Marom
In this review, we discuss the different radiation delivery techniques available to treat non-small cell lung cancer, typical radiologic manifestations of conventional radiotherapy, and different patterns of lung injury and temporal evolution of the newer radiotherapy techniques. More sophisticated techniques include intensity-modulated radiotherapy, stereotactic body radiotherapy, proton therapy, and respiration-correlated computed tomography or 4-dimensional computed tomography for radiotherapy planning. Knowledge of the radiation treatment plan and technique, the completion date of radiotherapy, and the temporal evolution of radiation-induced lung injury is important to identify expected manifestations of radiation-induced lung injury and differentiate them from tumor recurrence or infection...
May 2018: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/29622073/lung-cancer-biopsies
#15
REVIEW
Amita Sharma, Jo-Anne O Shepard
Image-guided percutaneous transthoracic needle biopsy (PTNB) is a well-established and minimally invasive technique for evaluating pulmonary nodules. Implementation of a national lung screening program and increased use of chest computed tomography have contributed to the frequent identification of indeterminate pulmonary nodules that may require tissue sampling. The advent of biomarker-driven lung cancer therapy has led to increased use of repeat PTNB after diagnosis. Percutaneous insertion of markers for preoperative localization of small nodules can aid in minimally invasive surgery and radiation treatment planning...
May 2018: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/29621872/dosimetric-comparison-of-imrt-versus-3dcrt-for-post-mastectomy-chest-wall-irradiation
#16
Kartick Rastogi, Shantanu Sharma, Shivani Gupta, Nikesh Agarwal, Sandeep Bhaskar, Sandeep Jain
PURPOSE: To compare the dose distribution of three-dimensional conformal radiation therapy (3DCRT) with intensity-modulated radiation therapy (IMRT) for post-mastectomy radiotherapy (PMRT) to left chest wall. MATERIALS AND METHODS: One hundred and seven patients were randomised for PMRT in 3DCRT group (n = 64) and IMRT group (n = 43). All patients received 50 Gy in 25 fractions. Planning target volume (PTV) parameters-Dnear-max (D2 ), Dnear-min (D98 ), Dmean , V95 , and V107 -homogeneity index (HI), and conformity index (CI) were compared...
March 2018: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29621871/impact-of-radiation-dose-on-concurrent-chemoradiotherapy-for-limited-stage-small-cell-lung-cancer
#17
Junhee Park, Min Kyu Kang
PURPOSE: To evaluate clinical outcomes according to radiation dose in patients with limited-stage small-cell lung cancer (LS-SCLC) treated with concurrent chemoradiotherapy (CCRT). MATERIALS AND METHODS: From January 2006 to December 2015, 38 patients with LS-SCLC were treated with CCRT with etoposide and cisplatin. Total radiation doses ranged from 45 Gy to 66 Gy (1.8-2 Gy/fraction) and were classified into three groups: 45-54 Gy, 60-63 Gy, and 66 Gy. The impact of radiation dose on survival outcomes were evaluated...
March 2018: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29619980/targeting-myeloid-derived-suppressor-cells-and-programmed-death-ligand-1-confers-therapeutic-advantage-of-ablative-hypofractionated-radiation-therapy-compared-with-conventional-fractionated-radiation-therapy
#18
Jie Lan, Rui Li, Li-Mei Yin, Lei Deng, Jun Gui, Bao-Qing Chen, Lin Zhou, Mao-Bin Meng, Qiao-Rong Huang, Xian-Ming Mo, Yu-Quan Wei, Bo Lu, Adam Dicker, Jian-Xin Xue, You Lu
PURPOSE: Ablative hypofractionated radiation therapy (AHFRT) presents a therapeutic advantage compared with conventional fractionated radiation therapy (CFRT) for primary and oligometastatic cancers. However, the underlying mechanisms remain largely unknown. In the present study, we compared the immune alterations in response to AHFRT versus CFRT and examined the significance of immune regulations contributing to the efficacy of AHFRT. METHODS AND MATERIALS: We established subcutaneous tumors using syngeneic lung cancer and melanoma cells in both immunocompetent and immunocompromised mice and treated them with AHFRT and CFRT under the same biologically equivalent dose...
May 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29619976/ablative-hypofractionated-radiation-therapy-enhances-non-small-cell-lung-cancer-cell-killing-via-preferential-stimulation-of-necroptosis-in-vitro-and-in-vivo
#19
Huan-Huan Wang, Zhi-Qiang Wu, Dong Qian, Nicholas G Zaorsky, Ming-Han Qiu, Jing-Jing Cheng, Chao Jiang, Juan Wang, Xian-Liang Zeng, Chun-Lei Liu, Li-Jun Tian, Guo-Guang Ying, Mao-Bin Meng, Xi-Shan Hao, Zhi-Yong Yuan
PURPOSE: To investigate how necroptosis (ie, programmed necrosis) is involved in killing of non-small cell lung cancer (NSCLC) after ablative hypofractionated radiation therapy (HFRT). METHODS AND MATERIALS: Deoxyribonucleic acid damage, DNA repair, and the death form of NSCLC cells were assessed after radiation therapy. The overexpression and silencing of receptor-interacting protein kinases 3 (RIP3, a key protein involved activation of necroptosis)-stable NSCLC cell lines were successfully constructed...
May 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29619964/stereotactic-ablative-radiation-therapy-versus-surgery-in-early-lung-cancer-a-meta-analysis-of-propensity-score-studies
#20
Hanbo Chen, Joanna M Laba, R Gabriel Boldt, Christopher D Goodman, David A Palma, Suresh Senan, Alexander V Louie
PURPOSE: As no completed randomized trials of surgery versus stereotactic ablative radiation therapy (SABR) in patients with early-stage non-small cell lung cancer are available, numerous propensity score studies have attempted to mimic the setting of clinical trials using nonrandomized data. We performed a meta-analysis of propensity score studies comparing SABR and surgery. METHODS AND MATERIALS: The MEDLINE and Embase databases were queried up to December 2016...
May 1, 2018: International Journal of Radiation Oncology, Biology, Physics
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