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developmental milestones

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https://www.readbyqxmd.com/read/28737141/designing-and-validation-of-a-hindi-language-parent-self-report-developmental-screening-tool
#1
Rahul Jain, Anshita Arora, Rohit Anand, Shahzadi Malhotra, Medha Mittal, Monica Juneja
AIM: To design and validate Hindi-language parent self-report developmental screening questionnaires for 9-month and 18-month-old Indian children. DESIGN: Cross-sectional study. SETTING: Tertiary-care pediatric hospital from April 2014 to March 2016. PARTICIPANTS: In each age group (9-month and 18-month), 45 children were enrolled for designing of questionnaires (30 for obtaining parental observations of current development and 15 for pre-testing)...
July 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28698706/personhood-status-of-the-human-zygote-embryo-fetus
#2
John Janez Miklavcic, Paul Flaman
The fields of biology, medicine, and embryology have described the developmental milestones of humans throughout gestation in great detail. It is less clear as to when humans are recognized as people, persons, or beings with rights that are protected by legislation. The practice of law is irrevocably intertwined with that of ethical conduct; and the time at which a human life is considered a person has implications that extend to health care, legislation on abortion, and autonomy of individuals. This article reviews the economical position that fertilization is the moment that personhood of the conceptus begins...
May 2017: Linacre Quarterly
https://www.readbyqxmd.com/read/28693014/a-groundbreaking-work-which-laid-the-foundation-for-mass-screening-in-cervical-cytology-in-japan
#3
Robert Y Osamura
This commentary discusses the impact of a milestone article on the accuracy of cervical smears for detecting cancer back in the developmental and transforming era of the cytological detection of atypical and malignant cells. The study served in the establishment of cancer screening in Japan which has contributed greatly in decreasing mortality from cervical cancers.
July 11, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/28688968/are-surgical-milestone-assessments-predictive-of-in-training-examination-scores
#4
Mary K Kimbrough, Carol R Thrush, Emily Barrett, Frederick R Bentley, Kevin W Sexton
OBJECTIVES: With the recent utilization of Accreditation Council for Graduate Medical Education developmental milestones as part of resident evaluation, we sought to explore whether milestone-based ratings were associated with American Board of Surgery In-Training Examination (ABSITE) scores. METHODS: Mid-year milestone ratings were obtained from the Accreditation Council for Graduate Medical Education Accreditation Database System for years 2014, 2015, and 2016 for all postgraduate years 1-5 general surgery residents in our program and paired with ABSITE scores (n = 69) from January of the following year...
July 5, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28685105/pediatric-perimeter-a-novel-device-to-measure-visual-fields-in-infants-and-patients-with-special-needs
#5
PremNandhini Satgunam, Sourav Datta, Koteswararao Chillakala, Karthik R Bobbili, Dhruv Joshi
PURPOSE: There are no commercially available devices to measure visual fields in infants. We developed a device, "Pediatric Perimeter," that quantifies visual field extent (VFE) for infants. We describe the construction, validation, and use of this device. METHODS: A hemispherical dome with light emitting diodes (LEDs) was constructed. The LEDs were controlled using a computer program to measure reaction time (RT) to gross visual fields (GVF) and the VFE. Participants were tested in supine position in a dark room...
July 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28648375/classifications-of-seizures-and-epilepsies-where-are-we-a-brief-historical-review-and-update
#6
REVIEW
Richard Shek-Kwan Chang, Chun Yin William Leung, Chi Chung Alvin Ho, Ada Yung
In March 2017, the International League Against Epilepsy (ILAE) announced their new classifications of seizures and epilepsies. Development of these classification systems led by the ILAE is a long and complicated process. Outsiders may find it difficult to understand the arguments behind. We summarize the major developmental milestones of the ILAE classification schemata. An update of the latest classification is also included. It is hope that this review can serve as an outline in learning the taxonomy in epileptology...
June 22, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28647393/the-effect-and-use-of-milestones-in-the-assessment-of-neurological-surgery-residents-and-residency-programs
#7
Lisa N Conforti, Nicholas A Yaghmour, Stanley J Hamstra, Eric S Holmboe, Benjamin Kennedy, Jesse J Liu, Heidi Waldo, Nathan R Selden
OBJECTIVES: The purpose of this study was to determine the effect of the Accreditation Council for Graduate Medical Education Milestones on the assessment of neurological surgery residents. The authors sought to determine the feasibility, acceptability, and utility of this new framework in making judgments of progressive competence, its implementation within programs, and the influence on curricula. Residents were also surveyed to elicit the effect of Milestones on their educational experience and professional development...
June 21, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28644755/a-contemporary-examination-of-first-and-second-permanent-molar-emergence
#8
B T Pahel, W F Vann, K Divaris, R G Rozier
The emergence of first permanent molars (FPMs) and second permanent molars (SPMs) is an important developmental milestone influencing caries risk and the timing of sealant placement. Emergence times have been shown to vary by sex and race/ethnicity, while recent reports suggest a positive association with adiposity. Amid the changing demographics of the US population and the rising rates of pediatric overweight/obesity, we sought to examine the association of body mass index (BMI) with FPM/SPM emergence in a representative sample of US children and adolescents...
June 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28644430/the-clinical-landscape-for-sma-in-a-new-therapeutic-era
#9
REVIEW
K Talbot, E F Tizzano
Despite significant advances in basic research, the treatment of degenerative diseases of the nervous system remains one of the greatest challenges for translational medicine. The childhood onset motor neuron disorder spinal muscular atrophy (SMA) has been viewed as one of the more tractable targets for molecular therapy, due to a detailed understanding of the molecular genetic basis of the disease. In SMA, inactivating mutations in the SMN1 gene can be partially compensated for by limited expression of SMN protein from a variable number of copies of the SMN2 gene, which provides both a molecular explanation for phenotypic severity and a target for therapy...
June 23, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28630251/valnoctamide-inhibits-cytomegalovirus-infection-in-developing-brain-and-attenuates-neurobehavioral-dysfunctions-and-brain-abnormalities
#10
Sara Ornaghi, Lawrence S Hsieh, Angélique Bordey, Patrizia Vergani, Michael J Paidas, Anthony N van den Pol
Cytomegalovirus (CMV) is the most common infectious cause of brain defects and neurological dysfunction in developing human babies. Due to the teratogenicity and toxicity of available CMV antiviral agents, treatment options during early development are markedly limited. Valnoctamide (VCD), a neuroactive mood stabilizer with no known teratogenic activity, was recently demonstrated to have anti-CMV potential. However, it is not known whether this can be translated into an efficacious therapeutic effect to improve CMV-induced adverse neurological outcomes...
July 19, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28615374/a-cross-sectional-survey-in-rural-bihar-india-indicates-that-nutritional-status-diet-and-stimulation-are-associated-with-motor-and-mental-development-in-young-children
#11
Leila M Larson, Melissa F Young, Usha Ramakrishnan, Amy Webb Girard, Pankaj Verma, Indrajit Chaudhuri, Sridhar Srikantiah, Reynaldo Martorell
Background: Many malnourished children in resource-poor settings fail to fulfill their developmental potential.Objectives: The objectives of this analysis were to examine the nutritional, psychosocial, environmental, and household correlates of child development in Bihar, India, and identify mediators between dietary diversity and mental development.Methods: Using 2-stage cluster randomized sampling, we surveyed 4360 households with children 6-18 mo of age in the West Champaran district of Bihar. We measured motor and mental development with the use of the Developmental Milestones Checklist II...
June 14, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28614480/-child-development-in-poor-areas-of-peru
#12
Adrián Alberto Díaz, Jorge Bacallao Gallestey, Rocío Vargas-Machuca, Roxana Aguilar Velarde
Objectives: The objective of the study was to demonstrate the influence of several socioeconomic factors on the motor and language development of children under 5 from the baseline study conducted within the framework of the Joint Program for Children, Food Security, and Nutrition, implemented by five United Nations agencies across 65 districts in the departments of Loreto, Ayacucho, Huancavelica, and Apurímac, Peru. Methods: Dichotomous logistic regression models were used to estimate the likelihood of achievement of motor and language milestones, while polynomial regression models were used to estimate the last milestone achieved and the number of milestones achieved...
June 8, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28607820/incidental-choroid-plexus-papilloma-in-a-child-a-difficult-decision
#13
Avra S Laarakker, Jonathan Nakhla, Andrew Kobets, Rick Abbott
BACKGROUND: Choroid plexus tumors (CPT) in the pediatric population are usually discovered in symptomatic patients often with symptoms of increased intracranial pressure, with hydrocephalus as the most common presentation, along with seizures, subarachnoid hemorrhage, or focal neurological deficit. Most CPTs are found to be benign choroid plexus papillomas (CPP), whereas a small number are intermediate and malignant choroid plexus carcinomas (CPC). Total surgical resection is the established definitive treatment for symptomatic CPP...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28600929/detrimental-effects-of-self-administered-methamphetamine-during-pregnancy-on-offspring-development-in-the-rat
#14
Daniela Rüedi-Bettschen, Donna M Platt
BACKGROUND: Methamphetamine (METH) abuse by pregnant women is a commonly observed phenomenon. While the harmful effects of METH are well described for adults, there is only limited knowledge of the effects of METH use during pregnancy on the developing child. In the present study, we investigated how intraveneous (iv) METH self-administration throughout pregnancy affected rat dams and their offspring through weaning, compared to controls. METHODS: Female rats (n=16) were trained to self-administer METH iv; every drug infusion by a dam also resulted in a saline injection to a yoked control (n=16)...
June 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28595647/pubertal-development-in-girls-by-breast-cancer-family-history-the-legacy-girls-cohort
#15
Mary Beth Terry, Theresa H M Keegan, Lauren C Houghton, Mandy Goldberg, Irene L Andrulis, Mary B Daly, Saundra S Buys, Ying Wei, Alice S Whittemore, Angeline Protacio, Angela R Bradbury, Wendy K Chung, Julia A Knight, Esther M John
BACKGROUND: Pubertal milestones, such as onset of breast development and menstruation, play an important role in breast cancer etiology. It is unclear if these milestones are different in girls with a first- or second-degree breast cancer family history (BCFH). METHODS: In the LEGACY Girls Study (n = 1040), we examined whether three mother/guardian-reported pubertal milestones (having reached Tanner Stage 2 or higher (T2+) for breast and pubic hair development, and having started menstruation) differed by BCFH...
June 8, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28557947/validity-evidence-from-ratings-of-pediatric-interns-and-subinterns-on-a-subset-of-pediatric-milestones
#16
Teri L Turner, Vasudha L Bhavaraju, Ulana A Luciw-Dubas, Patricia J Hicks, Sara Multerer, Amanda Osta, Jennifer McDonnell, Sue Poynter, Daniel J Schumacher, Rebecca Tenney-Soeiro, Linda Waggoner-Fountain, Alan Schwartz
PURPOSE: To investigate evidence for validity of faculty members' pediatric milestone (PM) ratings of interns (first-year residents) and subinterns (fourth-year medical students) on nine subcompetencies related to readiness to serve as a pediatric intern in the inpatient setting. METHOD: The Association of Pediatric Program Directors Longitudinal Educational Assessment Research Network (APPD LEARN) and the National Board of Medical Examiners collaborated to investigate the utility of assessments of the PMs for trainees' performance...
June 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28557682/an-infant-presenting-with-failure-to-thrive-and-hyperkalaemia-owing-to-transient-pseudohypoaldosteronism-case-report
#17
Marieke De Clerck, Johan Vande Walle, Evelyn Dhont, Joke Dehoorne, Werner Keenswijk
A 3-month-old boy presented with failure to thrive and a history of a prenatally detected unilateral hydroureteronephrosis which was confirmed after birth. His growth and developmental milestones had been normal during the first 2 months but in the third month his appetite was poor with reduced intake but no vomiting. At presentation, his temperature was normal, there was mild dehydration and there was weight loss (his weight had decreased by 270 g in the past month). Haemoglobin was 11.9 g/dL, total white cell count 20...
May 30, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28546662/pregnancy-outcome-in-patients-with-solitary-kidney
#18
Vineet V Mishra, Kavita M Mistry, Sakshi S Nanda, Sumesh Choudhary, Rohina Aggarwal, Khushali Gandhi
BACKGROUND: Solitary kidney may be congenital or as a result of nephrectomy. There is a lot of literature available on quality of life in these patients, but there is limited data on pregnancy outcome. OBJECTIVES: To study pregnancy outcome in patients with solitary kidney either congenital or due to nephrectomy. MATERIALS AND METHODS: Study Design This is a retrospective observational study conducted at tertiary health center in Ahmedabad, from 2011 to 2014...
June 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28543358/transient-arrest-of-germinal-vesicle-breakdown-improved-in-vitro-development-potential-of-buffalo-bubalus-bubalis-oocytes
#19
Sandeep Kumar, Manish Kumar, Sunny Dholpuria, Parul Sarwalia, Vipul Batra, Sachinandan De, Rakesh Kumar, T K Datta
Germinal vesicle breakdown (GVBD) is the first milestone that an oocyte needs to achieve towards completing the maturation and gaining potential to fertilise. Significantly lower in vitro embryo production rate in buffaloes can be attributed to heterogeneity of GVBD occurrence among oocytes obtained from abattoir derived ovaries. Evidence from our earlier work had suggested that different qualities of buffalo oocytes differ significantly in their timing of GVBD. Besides, these oocytes also differ in terms of volume of Akt phosphorylation, which initiates the process of GVBD...
May 25, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28537576/an-infant-and-mother-with-severe-b12-deficiency-vitamin-b12-status-assessment-should-be-determined-in-pregnant-women-with-anaemia
#20
A Sobczyńska-Malefora, R Ramachandran, D Cregeen, E Green, P Bennett, D J Harrington, H A Lemonde
The vitamin B12 status of infants depends on maternal B12 status during pregnancy, and during lactation if breastfed. We present a 9-month-old girl who was admitted to the metabolic unit for assessment of developmental delay. She was exclusively breastfed and the introduction of solids at 5 months was unsuccessful. Investigations revealed pancytopenia, undetectable B12 and highly elevated methylmalonic acid and homocysteine. Methylmalonic acid and homocysteine normalised following B12 injections. Marked catch-up of developmental milestones was noted after treatment with B12...
May 24, 2017: European Journal of Clinical Nutrition
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