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https://www.readbyqxmd.com/read/27896427/predictors-of-motor-developmental-milestones-during-the-first-year-of-life
#1
Trine Flensborg-Madsen, Erik Lykke Mortensen
: Studies suggest that both pre- and postnatal factors are predictors of age of attaining milestones in infancy. However, no studies evaluate the comparative strength of these predictors and the amount of the variance in development they explain. This study aimed to conduct a systematic evaluation of a broad selection of possible predictors of age at milestone attainment and to identify factors that explain significant inter-individual variance. Mothers of 5765 children of the Copenhagen Perinatal Cohort (1959-61) recorded 12 developmental milestones prospectively during the child's first year of life...
November 28, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27889381/do-developmental-milestones-at-4-8-12-and-24-months-predict-iq-at-5-6-years-old-results-of-the-eden-mother-child-cohort
#2
Hugo Peyre, Marie-Laure Charkaluk, Anne Forhan, Barbara Heude, Franck Ramus
RATIONALE: The present study aims: (i) to determine how well developmental milestones at 4, 8, 12 and 24 months may predict IQ at 5-6 years old, (ii) to identify cognitive domains during the first two years that best predict later IQ and (iii) to determine whether children with IQ in the normal range at 5-6 years old may differ from disabled (IQ < 70) and gifted children (IQ > 130) with regard to their early cognitive development. METHOD: The main developmental milestones were collected through self-administered questionnaires rated by parents at 4, 8, 12 and 24 months and through parental questionnaires administered by a trained interviewer and questionnaires completed following a medical examination at 12 months...
November 15, 2016: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27866496/building-a-translational-science-on-children-and-youth-affected-by-political-violence-and-armed-conflict-a-commentary
#3
Ann S Masten
Articles in this timely Special Section represent an important milestone in the developmental science on children and youth involved in political violence and armed conflict. With millions of children worldwide affected by past and present wars and conflicts, there is an urgent and growing need for research to inform efforts to understand, prevent, and mitigate the possible harm of such violence to individual children, families, communities, and societies, for present as well as future generations. The four programs of research highlighted in this Special Section illustrate key advances and challenges in contemporary development research on young people growing up in the midst or aftermath of political violence...
November 21, 2016: Development and Psychopathology
https://www.readbyqxmd.com/read/27854230/developmental-milestones-and-quality-of-life-assessment-in-a-congenital-myotonic-dystrophy-cohort
#4
Madhavi Prasad, Rhiannon Hicks, Melissa MacKay, Cam-Tu Nguyen, Craig Campbell
BACKGROUND: Congenital myotonic dystrophy (CDM) is a neuromuscular disorder caused by a CTG triplet repeat expansion in the DMPK gene. In addition to the expected motor delay, affected children often have significant developmental disability in language and cognitive realms, which ultimately impacts on quality of life. OBJECTIVE: In a prospective cohort of children with CDM to 1) present the profile of language and motor developmental milestones, and 2) describe their early childhood health related quality of life (HRQOL)...
August 30, 2016: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/27847348/characterization-of-infant-mu-rhythm-immediately-before-crawling-a-high-resolution-eeg-study
#5
Ran Xiao, Xiao Qi, Alejandro Patino, Andrew H Fagg, Thubi H A Kolobe, David P Miller, Lei Ding
Crawling is an important milestone in infant motor development. However, infants with developmental motor disorders can exhibit delays, or even miss, in the acquisition of crawling skill. And little information is available from the neurodevelopmental domain about the changes in brain function with intervention. The mu rhythm can potentially play a substantial role in understanding human motor development at early ages in infants, as it has in adults. Studies about the mu rhythm in infants were in coarse temporal resolution with longitudinal samples taken months or years apart...
November 12, 2016: NeuroImage
https://www.readbyqxmd.com/read/27843845/the-study-on-achievement-of-motor-milestones-and-associated-factors-among-children-in-rural-north-india
#6
Arti Gupta, Mani Kalaivani, Sanjeev Kumar Gupta, Sanjay K Rai, Baridalyne Nongkynrih
BACKGROUND: Nearly 14% of children worldwide do not reach their developmental potential in early childhood. The early identification of delays in achieving milestones is critical. The World Health Organization (WHO) has developed normal age ranges for the achievement of motor milestones by healthy children. This study aimed to assess the gross motor developmental achievements and associated factors among children in rural India. MATERIALS AND METHODS: A cross-sectional study was conducted with rural children in North India...
April 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/27822464/physical-and-mental-health-of-children-with-developmental-coordination-disorder
#7
REVIEW
Priscila Caçola
Developmental coordination disorder (DCD) is a neurodevelopmental condition characterized by poor motor proficiency that interferes with an individual's activities of daily living. These problems in motor coordination are prevalent despite children's intelligence levels. Common symptoms include marked delays in achieving motor milestones and clumsiness, typically associated with poor balance, coordination, and especially handwriting skills. Currently, DCD is said to impact about 2-7% of school-age children...
2016: Frontiers in Public Health
https://www.readbyqxmd.com/read/27796919/accrediting-graduate-medical-education-in-psychiatry-past-present-and-future
#8
REVIEW
Toni Johnson, Nadyah Janine John, Michael Lang, P G Shelton
The current terminology, goals, and general competency framework systematically utilized in the education of residents regardless of specialty is almost unrecognizable and quite foreign to those who trained before 2010. For example, the clinical and professional expectations for physicians-in-training have been placed onto a developmental framework of milestones. The expectations required during training have been expanded to include leadership and team participation skills, proficiency in the use of information technology, systems-based knowledge including respect of resources and cost of care, patient safety, quality improvement, population health and sensitivity to diversity for both individual and populations of patients...
October 28, 2016: Psychiatric Quarterly
https://www.readbyqxmd.com/read/27794483/anxiety-like-behaviors-in-adulthood-are-altered-in-male-but-not-female-rats-exposed-to-low-dosages-of-polychlorinated-biphenyls-in-utero
#9
Ross Gillette, Michael P Reilly, Viktoria Y Topper, Lindsay M Thompson, David Crews, Andrea C Gore
Exposure to polychlorinated biphenyls (PCBs), a class of endocrine-disrupting chemicals, can result in altered reproductive behavior in adulthood, especially when exposure occurs during critical periods of brain sexual differentiation in the fetus. Whether PCBs alter other sexually dimorphic behaviors such as those involved in anxiety is poorly understood. To address this, pregnant rat dams were injected twice, on gestational days 16 and 18, with the weakly estrogenic PCB mixture Aroclor 1221 (A1221) at one of two low dosages (0...
October 26, 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/27788403/preschool-children-use-space-rather-than-counting-to-infer-the-numerical-magnitude-of-digits-evidence-for-a-spatial-mapping-principle
#10
Francesco Sella, Ilaria Berteletti, Daniela Lucangeli, Marco Zorzi
A milestone in numerical development is the acquisition of counting principles which allow children to exactly determine the numerosity of a given set. Moreover, a canonical left-to-right spatial layout for representing numbers also emerges during preschool. These foundational aspects of numerical competence have been extensively studied, but there is sparse knowledge about the interplay between the acquisition of the cardinality principle and spatial mapping of numbers in early numerical development. The present study investigated how these skills concurrently develop before formal schooling...
October 24, 2016: Cognition
https://www.readbyqxmd.com/read/27770403/characterising-the-premonitory-stage-of-migraine-in-children-a-clinic-based-study-of-100-patients-in-a-specialist-headache-service
#11
N Karsan, P Prabhakar, P J Goadsby
BACKGROUND: The premonitory stage of migraine attacks, when symptomatology outside of pain can manifest hours to days before the onset of the headache, is well recognised. Such symptoms have been reported in adults in a number of studies, and have value in predicting an impending headache. These symptoms have not been extensively studied in children. We aimed to characterise which, if any, of these symptoms are reported in children seen within a Specialist Headache Service. METHODS: We reviewed clinic letters from the initial consultation of children and adolescents seen within the Specialist Headache Service at Great Ormond Street Hospital between 1999 and 2015 with migraine in whom we had prospectively assessed clinical phenotype data...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27769560/developmental-milestones-in-type-i-spinal-muscular-atrophy
#12
Roberto De Sanctis, Giorgia Coratti, Amy Pasternak, Jacqueline Montes, Marika Pane, Elena S Mazzone, Sally Dunaway Young, Rachel Salazar, Janet Quigley, Maria C Pera, Laura Antonaci, Leonardo Lapenta, Allan M Glanzman, Danilo Tiziano, Francesco Muntoni, Basil T Darras, Darryl C De Vivo, Richard Finkel, Eugenio Mercuri
The aim of this retrospective multicentric study was to assess developmental milestones longitudinally in type I SMA infants using the Hammersmith Infant Neurological Examination. Thirty-three type I SMA infants, who classically do not achieve the ability to sit unsupported, were included in the study. Our results confirmed that all patients had a score of 0 out of a scale of 4 on items assessing sitting, rolling, crawling, standing or walking. A score of more than 0 was only achieved in three items: head control (n = 13), kicking (n = 15) and hand grasp (n = 18)...
November 2016: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/27712125/the-impact-of-childhood-language-difficulties-on-healthcare-costs-from-4-to-13-years-australian-longitudinal-study
#13
Paula Cronin, Rebecca Reeve, Patricia Mccabe, Rosalie Viney, Stephen Goodall
PURPOSE: This study investigated the relationship between children's language difficulties and health care costs using the 2004-2012 Longitudinal Study of Australian Children (LSAC). METHOD: Language difficulties were defined as scores ≤1.25SD below the standardised mean on measures of directly assessed receptive vocabulary (4-9 years) and teacher-reported language and literacy (10-13 years). Participant data were individually linked to administrative data, which were sourced from Australia's universal subsidised healthcare scheme (Medicare)...
October 7, 2016: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/27703483/the-association-of-pseudohypoparathyroidism-type-ia-with-chiari-malformation-type-i-a-coincidence-or-a-common-link
#14
Paria Kashani, Madan Roy, Linda Gillis, Olufemi Ajani, M Constantine Samaan
A 19-month-old boy was referred for progressive weight gain. His past medical history included congenital hypothyroidism and developmental delay. Physical examination revealed characteristics of Albright Hereditary Osteodystrophy, macrocephaly, and calcinosis cutis. He had hypocalcemia, hyperphosphatemia, and elevated Parathyroid Hormone levels. Genetic testing revealed a known mutation of GNAS gene, confirming the diagnosis of Pseudohypoparathyroidism Type Ia (PHP-Ia) (c.34C>T (p.G1n12X)). He had a normal brain MRI at three months, but developmental delay prompted a repeat MRI that revealed Chiari Malformation Type I (CM-I) with hydrocephalus requiring neurosurgical intervention...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27697305/early-cardiac-involvement-in-an-infantile-sandhoff-disease-case-with-novel-mutations
#15
Hsiu-Fen Lee, Ching-Shiang Chi, Chi-Ren Tsai
INTRODUCTION: Hepatosplenomegaly is often present in infantile Sanshoff disease. However, cardiac involvement is extremely uncommon. CASE REPORT: We describe a 14-month-old female baby who exhibited mitral regurgitation and cardiomegaly at the age of 2months, dilation of the left atrium and left ventricle at age of 6months, followed by regression of developmental milestones after an episode of minor infection at age of 14months. Brain magnetic resonance imaging revealed signal changes over the bilateral thalami, bilateral cerebral white matter and left putamen...
September 30, 2016: Brain & Development
https://www.readbyqxmd.com/read/27697304/neurodevelopmental-outcome-of-term-infants-with-perinatal-asphyxia-with-hypoxic-ischemic-encephalopathy-stage-ii
#16
Sudhir Adhikari, Kalipatnam Seshagiri Rao
BACKGROUND: Perinatal asphyxia with hypoxic ischemic encephalopathy (HIE) causes significant mortality and morbidity in developing countries. There is limited information about long term neurodevelopmental outcome of infants with neonatal encephalopathy. METHODS: Term infants with the diagnosis of perinatal asphyxia were followed up in neurodevelopmental clinics of Manipal Teaching hospital, Nepal. Study design was prospective mixed longitudinal study. Prematurity, major congenital malformations, other intracranial pathology, birth weight <2500g and chromosomal abnormalities were excluded...
September 30, 2016: Brain & Development
https://www.readbyqxmd.com/read/27650623/first-korean-patients-with-craniofrontonasal-syndrome-confirmed-by-efnb1-analysis
#17
Hani Yoo, Jung Min Ko, Byung Chan Lim, Hae Il Cheong
Craniofrontonasal syndrome (CFNS) is a very rare genetic disorder with variable clinical phenotypes, including brachycephaly, hypertelorism, and a bifid nasal tip. Moreover, longitudinal splittings of the nails and skeletal abnormalities may accompany this condition. CFNS is inherited in an X-linked dominant manner; however, affected heterozygous females exhibit additional and more severe manifestations compared with affected hemizygous males, paradoxically. Here, we report for the first time in Korea two girls with molecularly confirmed CFNS...
September 2016: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/27612978/impact-of-a-child-stimulation-intervention-on-early-child-development-in-rural-peru-a-cluster-randomised-trial-using-a-reciprocal-control-design
#18
Stella Maria Hartinger, Claudio Franco Lanata, Jan Hattendorf, Jennyfer Wolf, Ana Isabel Gil, Mariela Ortiz Obando, Magaly Noblega, Hector Verastegui, Daniel Mäusezahl
OBJECTIVE: Stimulation in early childhood can alleviate adverse effects of poverty. In a community-randomised trial, we implemented 2 home-based interventions, each serving as an attention control for the other. One group received an integrated household intervention package (IHIP), whereas the other group received an early child development (ECD) intervention. The primary objective of the study was to evaluate the effect of IHIP on diarrhoea and respiratory infections, the details of which are described elsewhere...
September 9, 2016: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/27600842/the-tbr2-molecular-network-controls-cortical-neuronal-differentiation-through-complementary-genetic-and-epigenetic-pathways
#19
Alessandro Sessa, Ernesto Ciabatti, Daniela Drechsel, Luca Massimino, Gaia Colasante, Serena Giannelli, Takashi Satoh, Shizuo Akira, Francois Guillemot, Broccoli Vania
The T-box containing Tbr2 gene encodes for a transcription factor essential for the specification of the intermediate neural progenitors (INPs) originating the excitatory neurons of the cerebral cortex. However, its overall mechanism of action, direct target genes and cofactors remain unknown. Herein, we carried out global gene expression profiling combined with genome-wide binding site identification to determine the molecular pathways regulated by TBR2 in INPs. This analysis led to the identification of novel protein-protein interactions that control multiple features of INPs including cell-type identity, morphology, proliferation and migration dynamics...
September 6, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27571896/infantile-neurodegenerative-disorder-associated-with-mutations-in-tbcd-an-essential-gene-in-the-tubulin-heterodimer-assembly-pathway
#20
Shimon Edvardson, Guoling Tian, Hayley Cullen, Hannah Vanyai, Linh Ngo, Saiuj Bhat, Adi Aran, Muhannad Daana, Naderah Da'amseh, Bassam Abu-Libdeh, Nicholas J Cowan, Julian Heng, Orly Elpeleg
Mutation in a growing spectrum of genes is known to either cause or contribute to primary or secondary microcephaly. In primary microcephaly the genetic determinants frequently involve mutations that contribute to or modulate the microtubule cytoskeleton by causing perturbations of neuronal proliferation and migration. Here we describe four patients from two unrelated families each with an infantile neurodegenerative disorder characterized by loss of developmental milestones at 9-24 months of age followed by seizures, dystonia and acquired microcephaly...
August 29, 2016: Human Molecular Genetics
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