keyword
https://read.qxmd.com/read/38536675/a-novel-method-for-targeted-identification-of-essential-proteins-by-integrating-chemical-reaction-optimization-and-naive-bayes-model
#1
JOURNAL ARTICLE
Wenya Yang, Sai Zou, Hongfeng Gao, Lei Wang, Wei Ni
Targeted identification of essential proteins is of great significance for species identification, drug manufacturing, and disease treatment. It is a challenge to analyze the binding mechanism between essential proteins and improve the identification speed while ensuring the accuracy of the identification. This paper proposes a novel method called EPCRO for identifying essential proteins, which incorporates the chemical reaction optimization (CRO) algorithm and the naive Bayes model to effectively detect essential proteins...
March 27, 2024: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://read.qxmd.com/read/38536578/the-role-of-macrophages-in-lung-fibrosis-and-the-signaling-pathway
#2
REVIEW
Xingmei Wang, Jiaxu Zhou, Xinrui Li, Chang Liu, Lan Liu, Hong Cui
Lung fibrosis is a dysregulated repair process caused by excessive deposition of extracellular matrix that can severely affect respiratory function. Macrophages are a group of immune cells that have multiple functions and can perform a variety of roles. Lung fibrosis develops with the involvement of pro-inflammatory and pro-fibrotic factors secreted by macrophages. The balance between M1 and M2 macrophages has been proposed to play a role in determining the trend and severity of lung fibrosis. New avenues and concepts for preventing and treating lung fibrosis have emerged in recent years through research on mitochondria, Gab proteins, and exosomes...
March 27, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38535466/effects-of-polymannuronic-acid-on-the-intestinal-microbiota-in-mice-after-long-term-intragastric-administration
#3
JOURNAL ARTICLE
E Zhang, Qiang Wei, Xia Li, Shuliang Song
Polymannuronic acid (PM) is an alginate oligosaccharide derived from brown algae with a characterized structure and excellent biological activities. Herein, mice were given different doses of PM through 30-day-long-term intragastric administration, and the contents of the jejunum, ileum, and colon were analyzed by 16S rRNA gene sequencing technology for microbial diversity, and relevant experiments were verified according to the analysis results so as to comprehensively evaluate the effects of PM on the intestinal flora...
March 6, 2024: Marine Drugs
https://read.qxmd.com/read/38535326/reproductive-enhancement-through-phytochemical-characteristics-and-biological-activities-of-date-palm-pollen-a-comprehensive-review-on-potential-mechanism-pathways
#4
REVIEW
Saad Salhi, Abdellatif Rahim, Mouad Chentouf, Hasnaa Harrak, Jean Loup Bister, Naima Hamidallah, Bouchra El Amiri
Infertility represents a significant global health challenge affecting both men and women. Despite regular unprotected sexual intercourse, approximately 15% of couples of reproductive age struggle to conceive within 12 months, with 10% of infertility cases attributed to unknown causes worldwide. As a result, numerous studies have turned their attention to exploring the use of natural products for the prevention and treatment of infertility. Among these natural remedies is date palm pollen (DPP), a male reproductive powder derived from the blossoms of the Phoenix dactylifera L...
March 14, 2024: Metabolites
https://read.qxmd.com/read/38534735/microbial-based-bioactive-compounds-to-alleviate-inflammation-in-obesity
#5
REVIEW
Oladayo Emmanuel Apalowo, Grace Adeola Adegoye, Tolulope Mobolaji Obuotor
The increased prevalence of obesity with several other metabolic disorders, including diabetes and non-alcoholic fatty liver disease, has reached global pandemic proportions. Lifestyle changes may result in a persistent positive energy balance, hastening the onset of these age-related disorders and consequently leading to a diminished lifespan. Although suggestions have been raised on the possible link between obesity and the gut microbiota, progress has been hampered due to the extensive diversity and complexities of the gut microbiota...
February 28, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534450/insights-into-the-multifaceted-roles-of-thioredoxin-1-system-exploring-knockout-murine-models
#6
REVIEW
Tetiana Shcholok, Eftekhar Eftekharpour
Redox balance is increasingly identified as a major player in cellular signaling. A fundamentally simple reaction of oxidation and reduction of cysteine residues in cellular proteins is the central concept in this complex regulatory mode of protein function. Oxidation of key cysteine residues occurs at the physiological levels of reactive oxygen species (ROS), but they are reduced by a supply of thiol antioxidant molecules including glutathione, glutaredoxin, and thioredoxin. While these molecules show complex compensatory roles in experimental conditions, transgenic animal models provide a comprehensive picture to pinpoint the role of each antioxidant...
March 12, 2024: Biology
https://read.qxmd.com/read/38534340/mechanical-stress-induces-sodium-entry-and-osmoprotective-responses-in-murine-synovial-fibroblasts
#7
JOURNAL ARTICLE
Annemarie Proff, Ute Nazet, Agnes Schröder, Jonathan Jantsch
Osteoarthritis (OA) is a multifactorial disease depending on molecular, genetic, and environmental factors like mechanical strain. Next to the cartilage and the subchondral bone, OA also affects the synovium, which is critically involved in the maintenance of joint homeostasis. As there is a correlation between the extracellular sodium content in the knee joint and OA, this study investigates the impact of sodium on OA-associated processes like inflammation and bone remodeling without and with mechanical loading in synovial fibroblasts...
March 13, 2024: Cells
https://read.qxmd.com/read/38534315/cisplatin-and-starvation-differently-sensitize-autophagy-in-renal-carcinoma-a-potential-therapeutic-pathway-to-target-variegated-drugs-resistant-cancerous-cells
#8
JOURNAL ARTICLE
Ankita Dutta, Subarna Thakur, Debasish Kumar Dey, Anoop Kumar
Cisplatin, a powerful chemotherapy medication, has long been a cornerstone in the fight against cancer due to chemotherapeutic failure. The mechanism of cisplatin resistance/failure is a multifaceted and complex issue that consists mainly of apoptosis inhibition through autophagy sensitization. Currently, researchers are exploring ways to regulate autophagy in order to tip the balance in favor of effective chemotherapy. Based on this notion, the current study primarily identifies the differentially expressed genes (DEGs) in cisplatin-treated autophagic ACHN cells through the Illumina Hi-seq platform...
March 7, 2024: Cells
https://read.qxmd.com/read/38533987/paradoxical-activation-of-oncogenic-signaling-as-a-cancer-treatment-strategy
#9
JOURNAL ARTICLE
Matheus Henrique Dias, Anoek Friskes, Siying Wang, Joao M Fernandes Neto, Frank van Gemert, Soufiane Mourragui, Chrysa Papagianni, Hendrik J Kuiken, Sara Mainardi, Daniel Alvarez-Villanueva, Cor Lieftink, Ben Morris, Anna Dekker, Emma van Dijk, Lieke H S Wilms, Marcelo S da Silva, Robin A Jansen, Antonio Mulero-Sanchez, Elke Malzer, August Vidal, Cristina Santos, Ramon Salazar, Rosangela A M Wailemann, Thompson E P Torres, Giulia De Conti, Jonne A Raaijmakers, Petur Snaebjornsson, Shengxian Yuan, Wenxin Qin, John S Kovach, Hugo A Armelin, Hein Te Riele, Alexander van Oudernaarden, Haojie Jin, Roderick L Beijersbergen, Alberto Villanueva, Rene H Medema, Rene Bernards
Cancer homeostasis depends on a balance between activated oncogenic pathways driving tumorigenesis and engagement of stress-response programs that counteract the inherent toxicity of such aberrant signaling. While inhibition of oncogenic signaling pathways has been explored extensively, there is increasing evidence that overactivation of the same pathways can also disrupt cancer homeostasis and cause lethality. We show here that inhibition of Protein Phosphatase 2A (PP2A) hyperactivates multiple oncogenic pathways and engages stress responses in colon cancer cells...
March 27, 2024: Cancer Discovery
https://read.qxmd.com/read/38533401/h-2-o-2-drives-the-transition-from-conchocelis-to-conchosporangia-in-the-red-alga-pyropia-haitanensis-with-promotion-facilitated-by-1-aminocyclopropane-1-carboxylic-acid
#10
JOURNAL ARTICLE
Tingting Niu, Haike Qian, Haimin Chen, Qijun Luo, Juanjuan Chen, Rui Yang, Peng Zhang, Tiegan Wang
The Bangiales represent an ancient lineage within red algae that are characterized by a life history featuring a special transitional stage from diploid to haploid known as the conchosporangia stage. However, the regulatory mechanisms governing the initiation of this stage by changes in environmental conditions are not well understood. This study analyzed the changes in phytohormones and H2 O2 content during the development of conchosporangia. It also compared the gene expression changes in the early development of conchosporangia through transcriptome analysis...
2024: Frontiers in Plant Science
https://read.qxmd.com/read/38532458/a-phase-ii-study-of-belumosudil-for-chronic-graft-versus-host-disease-in-patients-who-failed-at-least-one-line-of-systemic-therapy-in-china
#11
JOURNAL ARTICLE
Ying Wang, Depei Wu, Xiang Zhang, Yuhua Li, Yanjie He, Qifa Liu, Li Xuan, Zhenyu Li, Kunming Qi, Yuqian Sun, Shunqing Wang, Wenjian Mo, Lei Gao, Ye Hua, Yu Wang, Ying Zhang
BACKGROUND: Chronic graft-versus-host disease (cGVHD) is an immune-related disorder that is the most common complication post-allogenic hematopoietic stem cell transplant. Corticosteroids with or without calcineurin inhibitors (CNIs) remain the mainstay of cGVHD treatment for first-line therapy. However, for many patients, cGVHD symptoms cannot be effectively managed and thus require second-line therapy. Currently, there is no approved treatment for second-line cGVHD treatment in China...
March 26, 2024: BMC Medicine
https://read.qxmd.com/read/38532340/overexpression-of-osduf6-increases-salt-stress-tolerance-in-rice
#12
JOURNAL ARTICLE
Guangming Ma, Yong Zhang, Xiangyang Li
BACKGROUND: Soil salinity is one of the primary environmental stresses faced in rice production. When plants are exposed to salt stress, a series of cellular balances will be disrupted. Dufulin is an immune-induced antiviral agent used in plants. The DUF gene family influences plant response to abiotic stress, and the functional role of OsDUF6(ABA98726.1) in rice response to salt stress is being investigated here. RESULTS: Based on the transcriptome analysis of Dufulin treatment in inducing salt tolerance in rice, we selected the OsDUF6 protein located on the cell membrane and studied its molecular function by overexpressing OsDUF6...
March 26, 2024: BMC Plant Biology
https://read.qxmd.com/read/38532272/an-integrative-review-of-home-care-recommendations-for-women-after-caesarean-section
#13
REVIEW
Mwajuma Bakari Mdoe, Lilian Teddy Mselle, Stephen Mathew Kibusi
AIM: To describe home-based care and practices recommended for mothers after caesarean section (CS), existing in the literature. DESIGN: Systematic review. METHODS: This integrative literature review was conducted by using Google Scholar, PubMed and Hinari databases from its inception to June 2021. The search included research articles, protocols and guidelines that describe home care practice after CS and assessed for their quality. Synthesis of recommendations from the included literature was classified based on the type of study design, and the review was guided by methodology registered in Prospero (ID CRD42021276905)...
March 2024: Nursing Open
https://read.qxmd.com/read/38531632/deletion-of-the-clock-gene-bmal2-leads-to-alterations-in-hypothalamic-clocks-circadian-regulation-of-feeding-and-energy-balance
#14
JOURNAL ARTICLE
Rosana Dantas-Ferreira, Dominique Ciocca, Patrick Vuillez, Stéphanie Dumont, Christian Boitard, Ute C Rogner, Etienne Challet
BMAL2 (ARNTL2) is a paralog of BMAL1 that can form heterodimers with the other circadian factors CLOCK and NPAS2 to activate transcription of clock and clock-controlled genes. To assess a possible role of Bmal2 in the circadian regulation of metabolism, we investigated daily variations of energy metabolism, feeding behavior, and locomotor behavior, as well as ability to anticipate restricted food access in male mice knock-out for Bmal2 (B2KO). While their amount of food intake and locomotor activity were normal compared to wild-type mice, B2KO mice displayed increased adiposity (1...
March 26, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38531330/err%C3%AE-1-and-aromatase-expression-in-human-placental-tissues-from-term-deliveries-of-large-for-gestational-age-lga-newborns
#15
JOURNAL ARTICLE
Marcos Abdul Palligas, Cristina Patricia Nemer, Claudia Monica Cannizzaro, Maria Sonia Baquedano, Alicia Belgorosky, Nora Saraco
INTRODUCTION: Being born either large (LGA) or small for gestational age (SGA) has been associated with an increased risk of developing metabolic syndrome in adulthood. However, the mechanism underlying this early programming remained unclear. Estrogen-related receptor gamma (ERRγ) is an orphan nuclear receptor with a high expression in human placenta, particularly ERRγ1. ERRγ has been proposed to play a central role in controlling genes involved in energy metabolism...
March 26, 2024: Hormone Research in Pædiatrics
https://read.qxmd.com/read/38530034/hiv-1-capsid-stability-and-reverse-transcription-are-finely-balanced-to-minimize-sensing-of-reverse-transcription-products-via-the-cgas-sting-pathway
#16
JOURNAL ARTICLE
Jenna E Eschbach, Maritza Puray-Chavez, Shawn Mohammed, Qiankun Wang, Ming Xia, Lin-Chen Huang, Liang Shan, Sebla B Kutluay
UNLABELLED: A critical determinant for early post-entry events, the HIV-1 capsid (CA) protein forms the conical core when it rearranges around the dimeric RNA genome and associated viral proteins. Although mutations in CA have been reported to alter innate immune sensing of HIV-1, a direct link between core stability and sensing of HIV-1 nucleic acids has not been established. Herein, we assessed how manipulating the stability of the CA lattice through chemical and genetic approaches affects innate immune recognition of HIV-1...
March 26, 2024: MBio
https://read.qxmd.com/read/38529291/connexin-43-in-the-function-and-homeostasis-of-osteocytes-a-narrative-review
#17
REVIEW
Liang Ma, Wenzhao Wang, Guixuan Xu, Hao Li, Fei Liu, Huarong Shao, Xiuhua Zhang, Yuxia Ma, Gang Li, Hui Li, Shuzhong Gao, Peixue Ling
BACKGROUND AND OBJECTIVE: Connexin 43 (Cx43) is the main gap junction (GJ) protein and hemichannel protein in bone tissue. It is involved in the formation of hemichannels and GJs and establishes channels that can communicate directly to exchange substances and signals, affecting the structure and function of osteocytes. CX43 is very important for the normal development of bone tissue and the establishment and balance of bone reconstruction. However, the molecular mechanisms by which CX43 regulates osteoblast function and homeostasis have been less well studied, and this article provides a review of research in this area...
2024: Annals of joint
https://read.qxmd.com/read/38528993/intestinal-flora-imbalance-induced-by-antibiotic-use-in-rats
#18
JOURNAL ARTICLE
Guojun Tong, Hai Qian, Dongli Li, Jing Li, Jing Chen, Xiongfeng Li, Zhenhua Tan
AIM: This study aims to explore the effect of different doses of antibiotics on rats in order to observe alterations in their fecal microbiota, inflammatory changes in the colonic mucosa and four types of inflammatory markers in blood serum. METHODS: Our methodology involved separating 84 female Sprague Dawley rats into groups A-G, with each group consisting of 12 rats. We collected the rat feces for analysis, using a distinct medium for bacterial cultivation and counting colonies under a microscope...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38528822/maladaptive-response-following-glucose-overload-in-glut4-overexpressing-h9c2-cardiomyoblasts
#19
JOURNAL ARTICLE
Bernd Stratmann, Britta Eggers, Yvonne Mattern, Tayana Silva de Carvalho, Katrin Marcus-Alic, Diethelm Tschoepe
BACKGROUND: Glucose overload drives diabetic cardiomyopathy by affecting the tricarboxylic acid pathway. However, it is still unknown how cells could overcome massive chronic glucose influx on cellular and structural level. METHODS/MATERIALS: Expression profiles of hyperglycemic, glucose transporter-4 (GLUT4) overexpressing H9C2 (KE2) cardiomyoblasts loaded with 30 mM glucose (KE230L) and wild type (WT) cardiomyoblasts loaded with 30 mM glucose (WT30L) were compared using proteomics, real-time polymerase quantitative chain reaction analysis, or Western blotting, and immunocytochemistry...
March 26, 2024: Diabetes, Obesity & Metabolism
https://read.qxmd.com/read/38528555/formononetin-reverses-treg-th17-imbalance-in-immune-mediated-bone-marrow-failure-mice-by-regulating-the-pi3k-akt-signaling-pathway
#20
JOURNAL ARTICLE
Huixuan Lan, Wei Qiu, Jie Wu, Zhijing Hu, Xiaomin Zhang, Lingling Zhu
BACKGROUND: Severe aplastic anemia (SAA) is a syndrome of bone marrow failure which is life-threatening. Recent studies have demonstrated that CD4 + T cell subsets, including T regulatory (Treg) and T helper 17 (Th17) cells, play a pivotal role in the pathogenesis of SAA. Formononetin (FMN) is a natural compound extracted from the traditional Chinese medicine Huangqi, which has the ability to regulate the imbalance of Treg/Th17 cells in some inflammatory diseases. Nevertheless, the therapeutic effect of FMN in SAA has yet to be definitively established...
March 25, 2024: Chinese Medicine
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