keyword
https://read.qxmd.com/read/38001940/comparative-efficacy-of-metformin-and-glimepiride-in-modulating-pharmacological-network-to-increase-bdnf-levels-and-benefit-type-2-diabetes-related-cognitive-impairment
#21
JOURNAL ARTICLE
Athira Anirudhan, Sheikh F Ahmad, Talha Bin Emran, Paola Isabel Angulo-Bejarano, Ashutosh Sharma, Shiek S S J Ahmed
Cognitive impairment is anotable complication of type 2 diabetes (T2DM), accompanied by reduced brain-derived neurotrophic factor (BDNF) in the brain and blood. Anti-diabetic drugs reduce hyperglycemia, yet their effect on cognitive improvement is unknown. We aimed to investigate the effect of anti-diabetic drugs regulating BDNF in T2DM through computational and case-control study design. We obtained T2DMproteins viatext-mining to construct a T2DMprotein network. From the T2DMnetwork, the metformin and glimepiride interactomes and their crucial shortest-path-stimulating BDNF were identified...
October 31, 2023: Biomedicines
https://read.qxmd.com/read/37995864/early-onset-diabetes-in-africa-a-mini-review-of-the-current-genetic-profile
#22
REVIEW
Samuel Mawuli Adadey, Joy Afua Mensah, Kojo Sekyi Acquah, Abugri James, Richard Osei-Yeboah
Early-onset diabetes is poorly diagnosed partly due to its heterogeneity and variable presentations. Although several genes have been associated with the disease, these genes are not well studied in Africa. We sought to identify the major neonatal, early childhood, juvenile, or early-onset diabetes genes in Africa; and evaluate the available molecular methods used for investigating these gene variants. A literature search was conducted on PubMed, Scopus, Africa-Wide Information, and Web of Science databases...
November 21, 2023: European Journal of Medical Genetics
https://read.qxmd.com/read/37994766/nutrigenomics-snps-correlated-to-detoxification-antioxidant-capacity-and-longevity
#23
REVIEW
G Bonetti, M C Medori, K Dhuli, A Macchia, K Donato, S Cristoni, S Miertus, J Miertus, D Veselenyiova, A Iaconelli, B Aquilanti, G Matera, S T Connelly, M Bertelli
Nutritional genomics, also known as nutrigenomics, is the study of how a person's diet and genes interact with each other. The field of nutrigenomics aims to explain how common nutrients, food additives and preservatives can change the body's genetic balance towards either health or sickness. This study reviews the effects of SNPs on detoxification, antioxidant capacity, and longevity. SNPs are mutations that only change one nucleotide at a specific site in the DNA. Specific SNPs have been associated to a variety of biological processes, including detoxification, antioxidant capacity, and longevity...
2023: La Clinica Terapeutica
https://read.qxmd.com/read/37873276/alterations-in-dna-5-hydroxymethylation-patterns-in-the-hippocampus-of-an-experimental-model-of-refractory-epilepsy
#24
Rudhab Bahabry, Rebecca M Hauser, Richard G Sánchez, Silvienne Sint Jago, Lara Ianov, Remy J Stuckey, R Ryley Parrish, Lawrence Ver Hoef, Farah D Lubin
Temporal lobe epilepsy (TLE) is a type of focal epilepsy characterized by spontaneous recurrent seizures originating from the hippocampus. The epigenetic reprogramming hypothesis of epileptogenesis suggests that the development of TLE is associated with alterations in gene transcription changes resulting in a hyperexcitable network in TLE. DNA 5-methylcytosine (5-mC) is an epigenetic mechanism that has been associated with chronic epilepsy. However, the contribution of 5-hydroxymethylcytosine (5-hmC), a product of 5-mC demethylation by the Ten-Eleven Translocation (TET) family proteins in chronic TLE is poorly understood...
October 5, 2023: bioRxiv
https://read.qxmd.com/read/37865384/dna-methylation-regulates-pancreatic-gene-expression-and-links-maternal-high-fat-diet-to-the-offspring-glucose-metabolism
#25
JOURNAL ARTICLE
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Maternal high-fat diet (HFD) is related to an increased risk of glucose metabolism disorders throughout the whole life of offspring. The pancreas is a glucose homeostasis regulator. Accumulating evidence has revealed that maternal HFD affects offspring pancreas structure and function. However, the potential mechanism remains unclear. In this study, the mouse dam was fed with HFD or control diet (CD) during prepregnancy, pregnancy and lactation. The pancreatic insulin secretion function and islet genome methylome of offspring were analyzed...
October 19, 2023: Journal of Nutritional Biochemistry
https://read.qxmd.com/read/37777789/genetically-proxied-antidiabetic-drugs-targets-and-stroke-risk
#26
JOURNAL ARTICLE
Yahui Zhu, Mao Li, Hongfen Wang, Fei Yang, Xinyuan Pang, Rongrong Du, Jinghong Zhang, Xusheng Huang
BACKGROUND: Previous studies have assessed the association between antidiabetic drugs and stroke risk, but the results are inconsistent. Mendelian randomization (MR) was used to assess effects of antidiabetic drugs on stroke risk. METHODS: We selected blood glucose-lowering variants in genes encoding antidiabetic drugs targets from genome-wide association studies (GWAS). A two-sample MR and Colocalization analyses were applied to examine associations between antidiabetic drugs and the risk of stroke...
September 30, 2023: Journal of Translational Medicine
https://read.qxmd.com/read/37732180/loss-of-atp-sensitive-channel-expression-and-function-decreases-opioid-sensitivity-in-a-mouse-model-of-type-2-diabetes
#27
Cole Fisher, Kayla Johnson, Madelyn Moore, Amir Sadrati, Jody L Janecek, Melanie L Graham, Amanda H Klein
During diabetes, β-cell dysfunction due to loss of potassium channels sensitive to ATP, known as K ATP channels occurs progressively over time contributing to hyperglycemia. K ATP channels are additionally present in the central and peripheral nervous systems and are downstream targets of opioid receptor signaling. The aim of this study is to investigate if K ATP channel expression or activity in the nervous system changes in diabetic mice and if morphine antinociception changes in mice fed a high fat diet (HFD) for 16 weeks compared to controls...
September 6, 2023: bioRxiv
https://read.qxmd.com/read/37664823/management-of-neonatal-diabetes-due-to-a-kcnj11-mutation-with-automated-insulin-delivery-system-and-remote-patient-monitoring
#28
Ming Yeh Lee, Anna L Gloyn, David M Maahs, Priya Prahalad
Neonatal diabetes mellitus (NDM) is a monogenic form of diabetes. Management of hyperglycemia in neonates with subcutaneous insulin is challenging because of frequent feeding, variable quantity of milk intake with each feed, low insulin dose requirements, and high risk for hypoglycemia and associated complications in this population. We present a case of NDM in a proband initially presenting with focal seizures and diabetic ketoacidosis due to a pathologic mutation in the beta cell potassium ATP channel gene KCNJ11 c...
2023: Case Reports in Endocrinology
https://read.qxmd.com/read/37602910/incretin-hormone-responses-to-carbohydrate-and-protein-fat-are-preserved-in-adults-with-sulfonylurea-treated-kcnj11-neonatal-diabetes
#29
JOURNAL ARTICLE
Pamela Bowman, Kashyap A Patel, Timothy J McDonald, Jens J Holst, Bolette Hartmann, Maria Leveridge, Beverley M Shields, Suzie Hammersley, Steve R Spaull, Bridget A Knight, Sarah E Flanagan, Maggie H Shepherd, Rob C Andrews, Andrew T Hattersley
The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are thought to be the main drivers of insulin secretion in individuals with sulfonylurea (SU)-treated KCNJ11 permanent neonatal diabetes. The aim of this study was to assess for the first time the incretin hormone response to carbohydrate and protein/fat in adults with sulfonylurea-treated KCNJ11 permanent neonatal diabetes compared with that of controls without diabetes. Participants were given a breakfast high in carbohydrate and an isocaloric breakfast high in protein/fat on two different mornings...
August 21, 2023: Journal of Diabetes Investigation
https://read.qxmd.com/read/37483435/identification-of-key-potassium-channel-genes-of-temporal-lobe-epilepsy-by-bioinformatics-analyses-and-experimental-verification
#30
JOURNAL ARTICLE
Lin-Ming Zhang, Ling Chen, Yi-Fei Zhao, Wei-Mei Duan, Lian-Mei Zhong, Ming-Wei Liu
One of the most prevalent types of epilepsy is temporal lobe epilepsy (TLE), which has unknown etiological factors and drug resistance. The detailed mechanisms underlying potassium channels in human TLE have not yet been elucidated. Hence, this study aimed to mine potassium channel genes linked to TLE using a bioinformatic approach. The results found that Four key TLE-related potassium channel genes (TERKPCGs) were identified: potassium voltage-gated channel subfamily E member ( KCNA ) 1, KCNA2 , potassium inwardly rectifying channel, subfamily J, member 11 ( KCNJ11 ), and KCNS1 ...
2023: Frontiers in Neurology
https://read.qxmd.com/read/37446299/the-yin-and-yang-of-breast-cancer-ion-channels-as-determinants-of-left-right-functional-differences
#31
JOURNAL ARTICLE
Sofía Masuelli, Sebastián Real, Patrick McMillen, Madeleine Oudin, Michael Levin, María Roqué
Breast cancer is a complex and heterogeneous disease that displays diverse molecular subtypes and clinical outcomes. Although it is known that the location of tumors can affect their biological behavior, the underlying mechanisms are not fully understood. In our previous study, we found a differential methylation profile and membrane potential between left (L)- and right (R)-sided breast tumors. In this current study, we aimed to identify the ion channels responsible for this phenomenon and determine any associated phenotypic features...
July 5, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37441495/decreased-igf1r-attenuates-senescence-and-improves-function-in-pancreatic-%C3%AE-cells
#32
JOURNAL ARTICLE
Kanako Iwasaki, Benjamin Lalani, Jiho Kahng, Priscila Carapeto, Stephanie Sanjines, Francesko Hela, Cristian Abarca, Tadataka Tsuji, Justin Darcy, Andrzej Bartke, Yu-Hua Tseng, Rohit N Kulkarni, Cristina Aguayo-Mazzucato
INTRODUCTION: The enhanced β-cell senescence that accompanies insulin resistance and aging contributes to cellular dysfunction and loss of transcriptional identity leading to type 2 diabetes (T2D). While senescence is among the 12 recognized hallmarks of aging, its relation to other hallmarks including altered nutrient sensing (insulin/IGF1 pathway) in β-cells is not fully understood. We previously reported that an increased expression of IGF1R in mouse and human β-cells is a marker of older β-cells; however, its contribution to age-related dysfunction and cellular senescence remains to be determined...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/37358194/optimization-of-a-glucagon-like-peptide-1-receptor-antagonist-antibody-for-treatment-of-hyperinsulinism
#33
JOURNAL ARTICLE
Sean M Peterson, Christine A Juliana, Cameron F Hu, Jinghua Chai, Carson Holliday, Kara Y Chan, Ana G Lujan Hernandez, Zoe Challocombe, Linya Wang, Zhen Han, Nikhil Haas, Ryan Stafford, Fumiko Axelrod, Tom Z Yuan, Diva D De León, Aaron K Sato
UNLABELLED: Congenital hyperinsulinism (HI) is a genetic disorder in which pancreatic β-cell insulin secretion is excessive and results in hypoglycemia that, without treatment, can cause brain damage or death. Most patients with loss-of-function mutations in ABCC8 and KCNJ11, the genes encoding the β-cell ATP-sensitive potassium channel (KATP), are unresponsive to diazoxide, the only U.S. Food and Drug Administration-approved medical therapy and require pancreatectomy. The glucagon-like peptide 1 receptor (GLP-1R) antagonist exendin-(9-39) is an effective therapeutic agent that inhibits insulin secretion in both HI and acquired hyperinsulinism...
September 1, 2023: Diabetes
https://read.qxmd.com/read/37341850/sex-differences-of-the-shared-genetic-landscapes-between-type-2-diabetes-and-peripheral-artery-disease-in-east-asians-and-europeans
#34
JOURNAL ARTICLE
Zhiya Lu, Haoyang Zhang, Yuanhao Yang, Huiying Zhao
Type 2 diabetes (T2D) is a critical risk factor for peripheral artery disease (PAD). However, the sex differences in genetic basis, causality, and underlying mechanisms of the two diseases are still unclear. Using sex-stratified and ethnic-based GWAS summary, we explored the genetic correlation and causal relationship between T2D and PAD in both ethnicities and sexes by linkage disequilibrium score regression, LAVA and six Mendelian Randomization approaches. We observed stronger genetic correlations between T2D and PAD in females than males in East Asians and Europeans...
July 2023: Human Genetics
https://read.qxmd.com/read/37336273/a-novel-mutation-in-the-kcnj11-gene-p-val36glu-predisposes-to-congenital-hyperinsulinemia
#35
JOURNAL ARTICLE
Idrees A Shah, Rabiya Rashid, Abid Bhat, Haroon Rashid, Rohina Bashir, Mir M Asrar, Imtiyaz A Wani, Bashir Ahmad Charoo, Venkatesan Radha, V Mohan, Mohd Ashraf Ganie
The hypoglycemia induced by insulin hypersecretion in congenital hyperinsulinemia (CHI), a rare life-threatening condition can lead to irreversible brain damage in neonates. Inactivating mutations in the genes encoding KATP channel (ABCC8 and KCNJ11) as well as HNF4A, HNF1A, HADH, UCP2, and activating mutations in GLUD1, GCK, and SLC16A1 have been identified as causal. A 3-month-old male infant presenting tonic-clonic seizures and hyperinsulinemia was clinically assessed and subjected to genetic analysis. Besides the index patient, his parents were clinically investigated, and a detailed family history was also recorded...
June 17, 2023: Gene
https://read.qxmd.com/read/37296241/mody-in-china-two-families-carrying-the-kcnj11-e229k-variant
#36
JOURNAL ARTICLE
Banghui Xiao, Hongmei Yi, Miao Zhang, Rui Wang, Ying Hu, Yi Xu, Zhijuan Shao, Song Zhang, Nianchun Peng
No abstract text is available yet for this article.
June 10, 2023: Acta Diabetologica
https://read.qxmd.com/read/37279235/pathological-features-in-non-neoplastic-congenital-and-adult-hyperinsulinism-from-nesidioblastosis-to-current-terminology-and-understanding
#37
REVIEW
Christine Sempoux, Günter Klöppel
Nesidioblastoma and nesidioblastosis were terms given to neoplastic and non-neoplastic lesions of the pancreas associated with pancreatogenous hyperinsulinaemic hypoglycaemia. While nesidioblastoma was rapidly replaced by islet cell tumour, nesidioblastosis, defined as the proliferation of islet cells budding off from pancreatic ducts, was the diagnostic term associated with congenital hyperinsulinism of infancy (CHI) and adult non-neoplastic hyperinsulinaemic hypoglycaemia (ANHH). When it was shown that nesidioblastosis was not specific for CHI or ANHH, it was no longer applied to CHI but kept for the morphological diagnosis of ANHH...
September 1, 2023: Endocrine-related Cancer
https://read.qxmd.com/read/37251668/case-report-better-late-than-never-but-sooner-is-better-switch-from-csii-to-sulfonylureas-in-two-patients-with-neonatal-diabetes-due-to-kcnj11-variants
#38
Valentina Mancioppi, Erica Pozzi, Sara Zanetta, Anna Missineo, Silvia Savastio, Fabrizio Barbetti, Simona Mellone, Mara Giordano, Ivana Rabbone
Neonatal diabetes mellitus (NDM) is a rare genetic disease characterized by severe hyperglycemia requiring insulin therapy with onset mostly within the first 6 months and rarely between 6-12 months of age. The disease can be classified into transient (TNDM) or permanent neonatal diabetes mellitus (PNDM), or it can be a component of a syndrome. The most frequent genetic causes are abnormalities of the 6q24 chromosomal region and mutations of the ABCC8 or KCNJ11 genes coding for the pancreatic beta cell's potassium channel (KATP)...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/37234928/validation-of-genome-wide-association-studies-gwas-identified-type-2-diabetes-mellitus-risk-variants-in-pakistani-pashtun-population
#39
JOURNAL ARTICLE
Asif Jan, Zakiullah, Fazli Khuda, Rani Akbar
OBJECTIVE: Recent GWAS largely conducted in European populations have successfully identified multiple genetic risk variants associated with Type 2 Diabetes Mellitus (T2DM). However, the effects conferred by these variants in the Pakistani population have not yet been fully elucidated. The objective of this study was to examine European GWAS-identified T2DM risk variants in the Pakistani Pashtun population to better understand the shared genetic basis of T2DM in the European and Pakistani cohorts...
2023: Journal of the ASEAN Federation of Endocrine Societies
https://read.qxmd.com/read/37180726/immunohistochemical-pharmacovigilance-and-omics-analyses-reveal-the-involvement-of-atp-sensitive-k-channel-subunits-in-cancers-role-in-drug-disease-interactions
#40
JOURNAL ARTICLE
Fatima Maqoud, Nicola Zizzo, Marcella Attimonelli, Antonella Tinelli, Giuseppe Passantino, Marina Antonacci, Girolamo Ranieri, Domenico Tricarico
Background: ATP-sensitive-K+ channels (KATP) are involved in diseases, but their role in cancer is poorly described. Pituitary macroadenoma has been observed in Cantu' syndrome (C.S.), which is associated with the gain-of-function mutations of the ABCC9 and KCNJ8 genes. We tested the role of the ABCC8 /Sur1, ABCC9 /Sur2A/B, KCNJ11 /Kir6.2, and KCNJ8 /Kir6.1 genes experimentally in a minoxidil-induced renal tumor in male rats and in the female canine breast cancer, a spontaneous animal model of disease, and in the pharmacovigilance and omics databases...
2023: Frontiers in Pharmacology
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