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https://www.readbyqxmd.com/read/29145710/testosterone-replacement-in-transgenic-sickle-cell-mice-controls-priapic-activity-and-upregulates-pde5-expression-and-enos-activity-in-the-penis
#1
B Musicki, S Karakus, W Akakpo, F H Silva, J Liu, H Chen, B R Zirkin, A L Burnett
Sickle cell disease (SCD)-associated priapism is characterized by decreased nitric oxide (NO) signaling and downregulated phosphodiesterase (PDE)5 protein expression and activity in the penis. Priapism is also associated with testosterone deficiency, but molecular mechanisms underlying testosterone effects in the penis in SCD are not known. Given the critical role of androgens in erection physiology and NO synthase (NOS)/PDE5 expression, we hypothesized that testosterone replacement to eugonadal testosterone levels reduces priapism by reversing impaired endothelial (e)NOS activity and molecular abnormalities involving PDE5...
November 16, 2017: Andrology
https://www.readbyqxmd.com/read/29143629/from-erasure-to-opportunity-a-qualitative-study-of-the-experiences-of-transgender-men-around-pregnancy-and-recommendations-for-providers
#2
Alexis Hoffkling, Juno Obedin-Maliver, Jae Sevelius
BACKGROUND: Some transgender men retain their uterus, get pregnant, and give birth. However, societal attitudes about gender have erected barriers to openly being pregnant and giving birth as a transgender man. Little research exists regarding transgender men's reproductive needs. Anecdotal observations suggest that social change and increasing empowerment of transgender men may result in increasing frequency and openness about pregnancy and birth. Specific needs around conception, pregnancy, and newborn care may arise from transphobia, exogenous testosterone exposure, or from having had (or desiring) gender-affirming surgery...
November 8, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29136657/contrasts-in-the-marine-ecosystem-of-two-macaronesian-islands-a-comparison-between-the-remote-selvagens-reserve-and-madeira-island
#3
Alan M Friedlander, Enric Ballesteros, Sabrina Clemente, Emanuel J Gonçalves, Andrew Estep, Paul Rose, Enric Sala
The islands of Madeira and Selvagens are less than 300 km apart but offer a clear contrast between a densely populated and highly developed island (Madeira), and a largely uninhabited and remote archipelago (Selvagens) within Macaronesia in the eastern Atlantic. The Madeira Archipelago has ~260,000 inhabitants and receives over six million visitor days annually. The Selvagens Islands Reserve is one of the oldest nature reserves in Portugal and comprises two islands and several islets, including the surrounding shelf to a depth of 200 m...
2017: PloS One
https://www.readbyqxmd.com/read/29135293/-from-the-hallervorden-spatz-eponym-to-the-molecular-terminology
#4
Ferenc Garzuly
INTRODUCTION AND AIM: A combination of Niemann-Pick- and Hallervorden-Spatz diseases led to the death of a 17-year-old boy in 1994. Genetic counseling necessitated further investigations in 2017. Meanwhile, the nomenclature of Hallervorden-Spatz disease has been abandoned. The author analyze the reasons for this change. METHOD: Professional activities of Hallervorden and Spatz during and after the Nazi euthanasia program are presented. Also, the scientific efforts that led to the discovery of the genetic background of the disease and ultimately to its new name are highlighted...
October 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29135149/-arterial-priapism-as-a-complication-of-a-stab-wound-in-the-perianal-area
#5
S K Yarovoi, R A Khromov, V N Shipovskii
The article describes a case of successful managenent of arterial priapism in a patient with a stab wound in the perianal area. Timely performed angiography revealed a pathological connection between a. Uretralis sinistra and spongy body. Disruption of the abnormal shunt resulted in immediate relief of erection with further preservation of erectile function. At the 3 and 6 months follow-up visits there were no signs of cavernous fibrosis or erectile dysfunction. The authors analyze the entire sequence of events in the management of the case, identify shortcomings, determine their significance and consider their prevention...
October 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29132462/-familial-male-limited-precocious-puberty-due-to-asp578his-mutations-in-the-lhcgr-gene-clinical-characteristics-and-gene-analysis-in-an-infant
#6
Min Wang, Min Li, Yue-Sheng Liu, Si-Min Lei, Yan-Feng Xiao
The aim of the study was to provide a descriptive analysis of familial male-limited precocious puberty (FMPP), which is a rare inherited disease caused by heterozygous constitutively activating mutations of the luteinizing hormone/choriogonadotropin receptor gene (LHCGR). The patient was a ten-month-old boy, presenting with penile enlargement, pubic hair formation, and spontaneous erections. Based on the clinical manifestations and laboratory data, including sexual characteristics, serum testosterone levels, GnRH stimulation test, and bone age, this boy was diagnosed with peripheral precocious puberty...
November 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29123449/fracture-with-urethral-injury-evaluation-by-retrograde-urethrogram
#7
Abdulkadir Kandemir, Mehmet Balasar, Necdet Poyraz, Mehmet Mesut Piskin
Penile fracture is a rare condition. It primarily involves the rupture of the corpus cavernosum during erection, which may also affect the corpus spongiosum and urethra. We describe the case of a 35-year-old man who presented with acute penile pain, penile swelling, and a hematuria after a blunt trauma during sexual intercourse. The emergency retrograde urethrogram revealed a rare condition, extravasation of the opaque material from the penile urethra into the cavernous structure. The partial rupture of the corpus cavernosum with urethral disruption was repaired surgically...
October 2017: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/29122494/penile-rehabilitation-therapy-following-radical-prostatectomy-a-meta-analysis
#8
REVIEW
Chunhui Liu, David S Lopez, Ming Chen, Run Wang
BACKGROUND: Penile rehabilitation, defined as the use of any drug or device at or after radical prostatectomy to maximize erectile function recovery, is commonly used for post-prostatectomy erectile dysfunction; however, conflicting results based on each study make it difficult to give a recommendation for clinical practice. AIM: To clarify the effect of oral phosphodiesterase type 5 inhibitors (PDE5is), vacuum erection devices, intracorporeal injection therapy, and the combination of these treatments on penile rehabilitation...
November 6, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29118652/isoetes-nana-a-new-species-from-the-coastal-mountains-of-southeastern-brazil
#9
Jovani B S Pereira, Thomas Stützel, Christian Schulz
Isoetes nana, a new species from the coastal mountains of southeastern Brazil (Serra de Itatiaia), is described, illustrated and compared to similar species. This species can be distinguished from similar species by a set of characters that include 5-15 small erect leaves reaching only up to 3.5cm long, megaspores rugulate (rarely laevigate or obscurely cristate) and microspores sparsely echinate. We include a key to identify this new species and spore images for all species that are discussed in this study...
2017: PhytoKeys
https://www.readbyqxmd.com/read/29118608/a-revision-of-the-family-ameroseiidae-acari-mesostigmata-with-some-data-on-slovak-fauna
#10
Peter Mašán
The family Ameroseiidae Evans, 1961 (Acari: Mesostigmata) includes a total of 12 valid and adequately described genera, namely Afrocypholaelaps Elsen, 1972, Ameroseiella Bregetova, 1977, Ameroseius Berlese, 1904, Asperolaelaps Womersley, 1956, Brontispalaelaps Womersley, 1956, Epicriopsis Berlese, 1916, Hattena Domrow, 1963, Kleemannia Oudemans, 1930, Neocypholaelaps Vitzthum, 1942, Pseudoameroseiusgen. n., Sertitympanum Elsen & Whitaker, 1985 and Sinoseius Bai & Gu, 1995. One of these genera includes subgenera, namely Kleemannia (Primoseius) Womersley, 1956...
2017: ZooKeys
https://www.readbyqxmd.com/read/29114253/overexpression-of-osrrk1-changes-leaf-morphology-and-defense-to-insect-in-rice
#11
Yinhua Ma, Yan Zhao, Xinxin Shangguan, Shaojie Shi, Ya Zeng, Yan Wu, Rongzhi Chen, Aiqing You, Lili Zhu, Bo Du, Guangcun He
It has been reported that the receptor-like cytoplasmic kinases (RLCKs) regulate many biological processes in plants, but only a few members have been functionally characterized. Here, we isolated a rice gene encoding AtRRK1 homology protein kinase, OsRRK1, which belongs to the RLCK VI subfamily. OsRRK1 transcript accumulated in many tissues at low to moderate levels and at high levels in leaves. Overexpression of OsRRK1 (OE-OsRRK1) caused adaxial rolling and erect morphology of rice leaves. In the rolled leaves of OE-OsRRK1 plants, both the number and the size of the bulliform cells are decreased compared to the wild-type (WT) plants...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29110808/how-big-is-too-big-the-girth-of-bestselling-insertive-sex-toys-to-guide-maximal-neophallus-dimensions
#12
Dylan Isaacson, Roxana Aghili, Non Wongwittavas, Maurice Garcia
BACKGROUND: In our practice we have encountered 4 female-to-male transgender patients seeking neophallus revision surgery for girth precluding penetrative vaginal or anal intercourse. Despite this, there is little evidence available to guide transitioning patients in neophallus sizing. In this work we examined the dimensions of bestselling realistic dildos, presuming that the most popular dimensions would reflect population preferences for penetrative toys and phalluses. AIM: To determine a maximal upper limit for girth compatible with penetrative intercourse based on measurements of bestselling realistic dildos and published erect penile dimensions...
November 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29110178/priapism-in-a-fabry-disease-mouse-model-is-associated-with-upregulated-penile-nnos-and-enos-expression
#13
Xing-Li Meng, Erland Arning, Mary Wight-Carter, Taniqua S Day, Siamak Jabbarzadeh-Tabrizi, Shuyuan Chen, Robin J Ziegler, Teodoro Bottiglieri, Jay W Schneider, Seng H Cheng, Raphael Schiffmann, Jin-Song Shen
Fabry disease is a glycosphingolipidosis caused by deficient activity of α-galactosidase A; it is one of a few diseases that are associated with priapism, an abnormal prolonged erection of the penis. The goal of this study was to investigate the pathogenesis of Fabry disease-associated priapism in a mouse model of the disease. We found that Fabry mice develop late-onset priapism. Neuronal nitric oxide synthase (nNOS), which was predominantly present as the 120-kDa N-terminus-truncated form, was significantly upregulated in the penis of 18-month-old Fabry mice compared to wild type controls (~fivefold)...
November 6, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29105668/-testosterone-replacement-therapy-and-cardiovascular-risk
#14
Giovanni Corona, Mauro Dicuio, Giulia Rastrelli, Alessandra Sforza, Mario Maggi
Late onset hypogonadism (LOH) is the most commonly used term to indicate the age-dependent reduction of testosterone. Sexual dysfunction represents the most important determinant for medical consultation and the most specific symptoms associated with LOH. In particular, data from the European Male Ageing Study (EMAS), a population-based survey on more than 3400 subjects, recognized that a triad of sexual symptoms (low libido and reduced spontaneous and sex-related erections) is the only syndromic association with decreased testosterone levels...
November 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29099876/archigregarines-of-the-english-channel-revisited-new-molecular-data-on-selenidium-species-including-early-described-and-new-species-and-the-uncertainties-of-phylogenetic-relationships
#15
Sonja Rueckert, Aleš Horák
BACKGROUND: Gregarines represent an important transition step from free-living predatory (colpodellids s.l.) and/or photosynthetic (Chromera and Vitrella) apicomplexan lineages to the most important pathogens, obligate intracellular parasites of humans and domestic animals such as coccidians and haemosporidians (Plasmodium, Toxoplasma, Eimeria, Babesia, etc.). While dozens of genomes of other apicomplexan groups are available, gregarines are barely entering the molecular age. Among the gregarines, archigregarines possess a unique mixture of ancestral (myzocytosis) and derived (lack of apicoplast, presence of subpellicular microtubules) features...
2017: PloS One
https://www.readbyqxmd.com/read/29095274/comparison-of-the-effects-of-extracorporeal-shock-wave-therapy-and-a-vacuum-erectile-device-on-penile-erectile-dysfunction-a-randomized-clinical-trial
#16
RANDOMIZED CONTROLLED TRIAL
Tao Qi, Lei Ye, Bo Wang, Bin Zhang, Jun Chen
BACKGROUND: This randomized clinical trial (October 2012-December 2013) compared extracorporeal shock wave therapy (ESWT) and a vacuum erectile device (VED) for management of erectile dysfunction (ED). METHODS: Consecutive Chinese patients (20-55 years) with ED, abnormal nocturnal penile tumescence and rigidity (NPTR), and international index of erectile function-5 items (IIEF-5) score <22 were randomized to receive ESWT or VED (twice weekly, 4 weeks). Primary outcomes were treatment efficacy and success rate 4 weeks after completion of therapy...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29093258/-treatment-of-varicocele-combined-with-asthenospermia-by-microsurgical-shunt-3-cases-report
#17
Shuang Wang, Xiongbing Zu, Longfei Liu, Juyu Tang, Xiheng Hu
To investigate the clinic value of microsurgical shunt for the treatment of varicocele combined with asthenspermia, the clinical data and therapeutic method for 3 patients, who conducted the microscope spermatic vein high ligation combined with superficial epigastric vein flow, were retrospectively analyzed. No postoperative complications were found, and the original symptoms and signs were disappeared. All patients were conducted scrotal ultrasound and semen routine after 3 months, and all indexes, including maximum internal diameter of the cord vein (erect position), sperm density, sperm survival rate, sperm deformity rate and sperm forward movement rate, were gradually improved...
October 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29084267/overexpression-of-arabidopsis-thaliana-brassinosteroid-related-acyltransferase-1-gene-induces-brassinosteroid-deficient-phenotypes-in-creeping-bentgrass
#18
Yun-Jeong Han, Young Soon Kim, Ok-Jin Hwang, Jeehee Roh, Keya Ganguly, Seong-Ki Kim, Ildoo Hwang, Jeong-Il Kim
Brassinosteroids (BRs) are naturally occurring steroidal hormones that play diverse roles in various processes during plant growth and development. Thus, genetic manipulation of endogenous BR levels might offer a way of improving the agronomic traits of crops, including plant architecture and stress tolerance. In this study, we produced transgenic creeping bentgrass (Agrostis stolonifera L.) overexpressing a BR-inactivating enzyme, Arabidopsis thaliana BR-related acyltransferase 1 (AtBAT1), which is known to catalyze the conversion of BR intermediates to inactive acylated conjugates...
2017: PloS One
https://www.readbyqxmd.com/read/29082117/oncology-section-edge-task-force-on-cancer-a-systematic-review-of-patient-reported-measures-for-sexual-dysfunction
#19
Meryl Alappattu, Shana E Harrington, Alexandra Hill, Amanda Roscow, Alicia Jeffrey
BACKGROUND: Sexual dysfunction is an important and infrequently addressed issue in patients with cancer. PURPOSE: To identify self-report measures for assessing sexual dysfunction and to evaluate their psychometric properties and relevance to patients with cancer. METHODS: Multiple electronic databases (CINAHL, Medline, PsycInfo) were reviewed using specific search terms to locate articles that identify self-report measures assessing sexual dysfunction...
July 2017: Rehabilitation Oncology
https://www.readbyqxmd.com/read/29080425/comparative-transcriptome-analysis-provides-new-insights-into-erect-and-prostrate-growth-in-bermudagrass-cynodon-dactylon-l
#20
Bing Zhang, Xiaolin Xiao, Junqin Zong, Jingbo Chen, Jianjian Li, Hailin Guo, Jianxiu Liu
Bermudagrass (Cynodon dactylon L.) is a prominent warm-season turf and forage grass species with multiple applications. In most C. dactylon cultivars and accessions, erect-growing stems (shoot) and prostrate-growing stems (stolon) often coexist. These two types of stems are both formed through tillering but grow in two directions with different tiller angles. Elucidating the mechanism of tiller angle regulation in bermudagrass could provide important clues to breed cultivars with different plant architectural features for diverse usage...
October 21, 2017: Plant Physiology and Biochemistry: PPB
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