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Qiuyun Fan, Aapo Nummenmaa, Barbara Wichtmann, Thomas Witzel, Choukri Mekkaoui, Walter Schneider, Lawrence L Wald, Susie Y Huang
We provide a comprehensive diffusion MRI dataset acquired with a novel biomimetic phantom mimicking human white matter. The fiber substrates in the diffusion phantom were constructed from hollow textile axons ("taxons") with an inner diameter of 11.8±1.2 µm and outer diameter of 33.5±2.3 µm. Data were acquired on the 3 T CONNECTOM MRI scanner with multiple diffusion times and multiple q-values per diffusion time, which is a dedicated acquisition for validation of microstructural imaging methods, such as compartment size and volume fraction mapping...
June 2018: Data in Brief
Giuseppina Rizzo, Demetrio Milardi, Salvatore Bertino, Gianpaolo Antonio Basile, Debora Di Mauro, Alessandro Calamuneri, Gaetana Chillemi, Giuseppe Silvestri, Giuseppe Anastasi, Alessia Bramanti, Alberto Cacciola
The amygdala plays a key role in gathering social cues to context-appropriate responses that require refined motor behaviour, involving either direct or indirect connections with sensorimotor-related areas. Although, several studies investigated the structural and functional limbic connectivity of the amygdala both in animals and in humans, less is known about the limbic modulation on sensorimotor-related areas. However, recent evidences suggest the amygdala as a possible cornerstone in the limbic-motor interface...
June 8, 2018: Neuroscience
Carmen Messerlian, Paige L Williams, Jennifer B Ford, Jorge E Chavarro, Lidia Mínguez-Alarcón, Ramace Dadd, Joseph M Braun, Audrey J Gaskins, John D Meeker, Tamarra James-Todd, Yu-Han Chiu, Feiby L Nassan, Irene Souter, John Petrozza, Myra Keller, Thomas L Toth, Antonia M Calafat, Russ Hauser
Background: The Environment and Reproductive Health (EARTH) Study is an ongoing prospective preconception cohort designed to investigate the impact of environmental, nutritional, and lifestyle factors among both women and men on fertility and pregnancy outcomes. Methods: The EARTH Study recruits women 18 to 45 years and men 18 to 55 years seeking fertility evaluation and treatment at the Massachusetts General Hospital (MGH) Fertility Center, Boston, USA. Women and men are eligible to join either independently or as a couple...
February 2018: Human reproduction open
Xiaoliang Li, Zhibin Wang, Yu Wang, Yanan Zhang, Xia Lei, Ping Xin, Xin Fu, Ning Gao, Yanping Sun, Yanhong Wang, Bingyou Yang, Qiuhong Wang, Haixue Kuang
Mammary gland hyperplasia (MGH) is a pathological condition that affects the majority of women at the child-bearing stage. The hormone and endocrinal therapy are typically used to treat MGH. Nevertheless, there are still some certain side effects accompanied with the benefits, which negatively affect the life quality of patients. Therefore, plant-derived agents that are effective against MGH development and with fewer side effects should be developed. The aim of this study was to investigate the protective effects and underlying mechanism of total saponins of Phytolaccae (TSP) against MGH in vivo ...
2018: Frontiers in Pharmacology
Hongming Shan, Yi Zhang, Qingsong Yang, Uwe Kruger, Mannudeep K Kalra, Ling Sun, Wenxiang Cong, Ge Wang
Low-dose computed tomography (LDCT) has attracted major attention in the medical imaging field, since CT-associated X-ray radiation carries health risks for patients. The reduction of the CT radiation dose, however, compromises the signal-to-noise ratio, which affects image quality and diagnostic performance. Recently, deep-learning-based algorithms have achieved promising results in LDCT denoising, especially convolutional neural network (CNN) and generative adversarial network (GAN) architectures. This paper introduces a conveying path-based convolutional encoder-decoder (CPCE) network in 2-D and 3-D configurations within the GAN framework for LDCT denoising...
June 2018: IEEE Transactions on Medical Imaging
Juwita N Rahmat, Kesavan Esuvaranathan, Ratha Mahendran
Bacillus Calmette-Guérin (BCG) immunotherapy is the standard therapy for non-muscle invasive bladder cancer. The aim of the present study was to identify genes that are induced in response to BCG immunotherapy, as these may be potential biomarkers for the response to clinical therapy. To model clinical therapy, human bladder cancer cell lines were incubated with BCG (live or lyophilized BCG Connaught) for 2 h. RNA was extracted and evaluated by Representational Differential Analysis (RDA) and oligo arrays...
June 2018: Oncology Letters
Uri Kartoun, Rahul Aggarwal, Andrew L Beam, Jennifer K Pai, Arnaub K Chatterjee, Timothy P Fitzgerald, Isaac S Kohane, Stanley Y Shaw
We developed an insomnia classification algorithm by interrogating an electronic medical records (EMR) database of 314,292 patients. The patients received care at Massachusetts General Hospital (MGH), Brigham and Women's Hospital (BWH), or both, between 1992 and 2010. Our algorithm combined structured variables (such as International Classification of Diseases 9th Revision [ICD-9] codes, prescriptions, laboratory observations) and unstructured variables (such as text mentions of sleep and psychiatric disorders in clinical narrative notes)...
May 18, 2018: Scientific Reports
S Raymundo, V V Muller, N B Andriguetti, M Tegner, A C Artmann, H M Kluck, M A Franzoi, R M M Vilela, G Schwartsmann, R Linden, M V Antunes
In this study, a LC-MS/MS method for the measurement of docetaxel in Dried Blood Spots (DBS) samples was developed and validated. Docetaxel was extracted from 8 mm DBS punch with a mixture of methanol and acetonitrile (9:1, v/v). The chromatographic separation occurred in an Acquity® C18 column (150 × 2.1 mm, 1.7 μm) eluted with a mixture of water and acetonitrile plus 0.1% formic acid (45:55, v/v). Total analytical run time was 7 min. The method was linear from 50 to 3000 ng ml-1 . Precision assays showed CV% < 9...
May 15, 2018: Journal of Pharmaceutical and Biomedical Analysis
Anne-Frédérique Pécharman, Michael S Hill, Mary F Mahon
Reaction of the dimeric β-diketiminato magnesium hydride [(BDI)MgH]2 (BDI = HC{(Me)CN-2,6-i-Pr2C6H3}2) with bis-pinacolatodiborane (B2pin2) resulted in B-O bond activation and formation of a magnesium complex of an unusual borylborohydride anion. In contrast, similar treatment of the mononuclear organomagnesium [{BDI}Mg(n-Bu)] with 4,4,4',4',6,6'-hexamethyl-2,2'-bi(1,3,2-dioxaborinane) (B2hex2) provided a B(sp2)-B(sp3) diborane anion, [(hex)BB(n-Bu)(hex)]-, with a constitution which is analogous to that formed in the previously reported reaction with bis(pinacolato)diboron (B2pin2)...
May 17, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Mark T Seelen, Tynan H Friend, Wilton C Levine
The Massachusetts General Hospital (MGH) is merging its older endoscope processing facilities into a single new facility that will enable high-level disinfection of endoscopes for both the ORs and Endoscopy Suite, leveraging economies of scale for improved patient care and optimal use of resources. Finalized resource planning was necessary for the merging of facilities to optimize staffing and make final equipment selections to support the nearly 33,000 annual endoscopy cases. To accomplish this, we employed operations management methodologies, analyzing the physical process flow of scopes throughout the existing Endoscopy Suite and ORs and mapping the future state capacity of the new reprocessing facility...
May 4, 2018: Journal of Medical Systems
Graham G Willsey, Sebastian Ventrone, Kristin C Schutz, Aaron M Wallace, John W Ribis, Benjamin T Suratt, Matthew J Wargo
The interactions between K lebsiella pneumoniae and the host environment at the site of infection largely unknown. Pulmonary surfactant serves as an initial point of contact for inhaled bacteria entering the lung and is thought to contain molecular cues that aid colonization and pathogenesis. To gain insight into this ecological transition, we characterized the transcriptional response of K. pneumoniae MGH 78578 to purified pulmonary surfactant. This work revealed changes within the K. pneumoniae transcriptome that likely contribute to host colonization, adaptation, and virulence in vivo Notable transcripts expressed under these conditions include genes involved in capsule synthesis, LPS modification, antibiotic resistance, biofilm formation, and metabolism...
April 30, 2018: Infection and Immunity
Luis F Tapias, Douglas J Mathisen
Tracheal surgery has developed and evolved over the last 50 years, becoming an integral part of the clinical practice of modern thoracic surgeons. Today, surgeons can safely and effectively operate on most patients suffering from post-intubation tracheal stenosis, tracheal tumors and other pathologies that result in an abnormal shape and function of the central airways. The Massachusetts General Hospital (MGH) in Boston witnessed first-hand the birth and growth of tracheal surgery under Dr. Hermes Grillo, becoming a reference center and accumulating one of the largest institutional experiences in the world...
March 2018: Annals of Cardiothoracic Surgery
John M Kane, Anthony Magliocco, Qiang Zhang, Dian Wang, Alex Klimowicz, Jonathan Harris, Jeff Simko, Thomas DeLaney, William Kraybill, David G Kirsch
Background: Sarcoma mortality remains high despite adjuvant chemotherapy. Biomarker predictors of treatment response and outcome could improve treatment selection. Methods: Tissue microarrays (TMAs) were created using pre- and posttreatment tumor from two prospective trials (MGH pilot and RTOG 9514) of neoadjuvant/adjuvant MAID chemotherapy and preoperative radiation. Biomarkers were measured using automated computerized imaging (AQUA or ACIS). Expression was correlated with disease-free survival (DFS), distant disease-free survival (DDFS), and overall survival (OS)...
2018: Sarcoma
Yee-Ming Chan, Margaret F Lippincott, Temitope O Kusa, Stephanie B Seminara
BACKGROUND: The neuropeptide kisspeptin stimulates luteinizing hormone (LH) secretion in healthy adults but not in adults with idiopathic hypogonadotropic hypogonadism. We hypothesized that, in children presenting with delayed or stalled puberty, kisspeptin would elicit LH secretion in those children found on detailed nighttime neuroendocrine profiling to have evidence of emerging reproductive endocrine function. METHODS: Eleven boys and four girls were admitted overnight to assess LH secretion at baseline, after a single intravenous bolus of kisspeptin, and after a single intravenous bolus of gonadotropin-releasing hormone (GnRH)...
April 19, 2018: JCI Insight
Jinpin Li, Di Qiu, Zezhi Chen, Weiwei Du, Jingli Liu, Xuean Mo
Myasthenia gravis (MG) is a B cell-mediated and T cell-dependent autoimmune disease. Thymic hyperplasia has great significance for MG pathogenesis and treatment. MicroRNAs (miRNAs) are a newly recognized type of gene expression regulatory factor that regulate gene expression at the post-transcriptional level. Additionally, miRNAs are involved in immune regulation of the thymus and the occurrence and development of autoimmune diseases. In this study, we found 33 miRNAs that were significantly dysregulated in thymic tissues from MG patients with thymus hyperplasia (MGH) compared with thymic tissues from normal controls using a miRNA microarray chip...
July 15, 2018: Journal of Neuroimmunology
Yusuke Matsui, Yosuke Funato, Hiromi Imamura, Hiroaki Miki, Shin Mizukami, Kazuya Kikuchi
Mg2+ plays important roles in many physiological processes. However, the underlying molecular mechanisms, especially in the apoptotic pathway, remain unclear due to the diffusion of Mg2+ probes, which hinders long-term imaging in specific organelles. We developed an immobilized Mg2+ probe, MGH, which is covalently conjugated with the HaloTag protein in various organelles. HaloTag-coupled MGH enabled long-term imaging of intracellular local Mg2+ dynamics for 24 h. To exploit this remarkable property, MGH was applied to the investigation of intracellular Mg2+ dynamics during apoptosis...
December 1, 2017: Chemical Science
Jeeheh Oh, Maggie Makar, Christopher Fusco, Robert McCaffrey, Krishna Rao, Erin E Ryan, Laraine Washer, Lauren R West, Vincent B Young, John Guttag, David C Hooper, Erica S Shenoy, Jenna Wiens
OBJECTIVE An estimated 293,300 healthcare-associated cases of Clostridium difficile infection (CDI) occur annually in the United States. To date, research has focused on developing risk prediction models for CDI that work well across institutions. However, this one-size-fits-all approach ignores important hospital-specific factors. We focus on a generalizable method for building facility-specific models. We demonstrate the applicability of the approach using electronic health records (EHR) from the University of Michigan Hospitals (UM) and the Massachusetts General Hospital (MGH)...
April 2018: Infection Control and Hospital Epidemiology
Suheyla Cetin Karayumak, Evren Özarslan, Gozde Unal
Characterization of anisotropy via diffusion MRI reveals fiber crossings in a substantial portion of voxels within the white-matter (WM) regions of the human brain. A considerable number of such voxels could exhibit asymmetric features such as bends and junctions. However, widely employed reconstruction methods yield symmetric Orientation Distribution Functions (ODFs) even when the underlying geometry is asymmetric. In this paper, we employ inter-voxel directional filtering approaches through a cone model to reveal more information regarding the cytoarchitectural organization within the voxel...
June 2018: Magnetic Resonance Imaging
Wei Zhang, Guang Xu, Ying Cheng, Lingjuan Chen, Quan Huo, Suyan Liu
The sulfide catalyst is a subject of great interest in developing a MgH2 system as a potential hydrogen storage medium. In this work, FeS2 micro-spheres were successfully prepared by the surfactant-assisted solvothermal method, and later were ball milled with MgH2 to fabricate the MgH2-16.7 wt% FeS2 composite. FeS2 addition could dramatically improve both the hydrogenation and dehydrogenation kinetics, and lower the dehydrogenation temperature of MgH2 as well. The MgH2-16.7 wt% FeS2 composite could absorb 3...
April 17, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Charles M Laymon, Davneet S Minhas, Carl R Becker, Cristy Matan, Matthew J Oborski, Julie C Price, James M Mountz
PURPOSE: In dual modality positron emission tomography (PET)/magnetic resonance imaging (MRI), attenuation correction (AC) methods are continually improving. Although a new AC can sometimes be generated from existing MR data, its application requires a new reconstruction. We evaluate an approximate 2D projection method that allows offline image-based reprocessing. PROCEDURE: 2-Deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) brain scans were acquired (Siemens HR+) for six subjects...
February 27, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
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