Read by QxMD icon Read


Jiuchuang Yuan, Di He, Shufen Wang, Maodu Chen, Keli Han
The global diabatic potential energy surfaces (PESs) of the MgH2 + system, which can be used to study the dynamics of the Mg+ (3p2 P) + H2 (X1 Σ) → MgH+ (X1 Σ+ ) + H(2 S) reaction, are structured for the first time. The diabatic PESs are correlated with the ground state 12 A' and the first excited state 22 A'. The multi-reference configuration interaction method and the VQZ basis set are used in ab initio calculations, and diabatic potential energies are calculated based on the molecular properties of the dipole moment...
February 19, 2018: Physical Chemistry Chemical Physics: PCCP
Hao-Tian Li, Hong-Hong Liu, Yu-Xue Yang, Tao Wang, Xue-Lin Zhou, Yang Yu, Su-Na Li, Yi Zheng, Ping Zhang, Rui-Lin Wang, Jian-Yu Li, Shi-Zhang Wei, Kun Li, Peng-Yan Li, Li-Qi Qian
As a common disorder that accounts for over 70% of all breast disease cases, mammary gland hyperplasia (MGH) causes a severe problem for the quality of patients' life, and confers an increased risk of breast carcinoma. However, the etiology and pathogenesis of MGH remain unclear, and the safety and efficacy of current western drug therapy for MGH still need to be improved. Therefore, a meta-analysis was conducted by our team to determine whether a TCM formula named Ru-Pi-Xiao in combination with tamoxifen or Ru-Pi-Xiao treated alone can show more prominent therapeutic effects against MGH with fewer adverse reactions than that of tamoxifen...
2018: Frontiers in Pharmacology
Matheus Oliveira da Silva, Marcella Lemos Brettas Carneiro, Joseílma Luciana Neves Siqueira, Sônia Nair Báo, Aparecido Ribeiro de Souza
In this study, we report the synthesis and characterization of a new rhodium(II) succinate complex (Rh2(suc)4) and its immobilization on lauric acid bilayer-coated maghemite nanoparticles (MGH-2L/Rh2(suc)4) and subsequent adsorption with bovine serum albumin (MGH-2L/Rh2(suc)4/BSA). Rh2(suc)4 has been characterized by elemental analysis, potentiometric titration, TGA, MS, FTIR and UV-Vis analysis. The maghemite phase was confirmed by XRD, and a diameter of 10 nm was obtained by Sherrer equation. The VSM experiment showed superparamagnetic properties...
June 1, 2018: Journal of Nanoscience and Nanotechnology
Mercy Abbey, Seth Kwaku Afagbedzi, Jane Afriyie-Mensah, David Antwi-Agyei, Kirchuffs Atengble, Ebenezer Badoe, James Batchelor, Eric S Donkor, Reuben Esena, Bamenla Q Goka, Michael G Head, Appiah-Korang Labi, Edmund Nartey, Isabella Sagoe-Moses, Edem M A Tette
Despite the high mortality, pneumonia retains a relatively low profile among researchers, funders and policymakers. Here we reflect on the problems and priorities of pneumonia in Ghana, briefly review the evidence base and reflect upon in-person discussions between Southampton-based authors MGH and JB and academic, clinical and policy colleagues in Ghana. The discussions took place in Accra in August 2017.
February 1, 2018: International Health
Ashkan Ghanbarzadeh Dagheyan, Ali Molaei, Richard Obermeier, Andrew Westwood, Aida Martinez, Jose Angel Martinez Lorenzo
Accurate and early detection of breast cancer is of high importance, as it is directly associated with the patients' overall well-being during treatment and their chances of survival. Uncertainties in current breast imaging methods can potentially cause two main problems: (1) missing newly formed or small tumors; and (2) false alarms, which could be a source of stress for patients. A recent study at the Massachusetts General Hospital (MGH) indicates that using Digital Breast Tomosynthesis (DBT) can reduce the number of false alarms, when compared to conventional mammography...
January 25, 2018: Sensors
Luca Pinello, Rick Farouni, Guo-Cheng Yuan
Motivation: With the increasing amount of genomic and epigenomic data in the public domain, a pressing challenge is to integrate these data to investigate the role of epigenetic mechanisms in regulating gene expression and maintenance of cell-identity. To this end, we have implemented a computational pipeline to systematically study epigenetic variability and uncover regulatory DNA sequences. Results: Haystack is a bioinformatics pipeline to identify hotspots of epigenetic variability across different cell-types, cell-type specific cis-regulatory elements, and associated transcription factors...
January 17, 2018: Bioinformatics
Xian Zhao, Mi Hou
OBJECTIVE: To observe the effects of acupuncture combined with Rule granule on breast tissue, prolactin(PRL) and prolactin receptor (PRLR) expression in rats with mammary gland hyperplasia (MGH), and to explore its action mechanism to provide reference for clinical treatment of MGH. METHODS: Fifty-five female SD rats were randomly divided into a blank group, a model group, an acupuncture group, a Rule granule group and a combination group. Except the blank group, the rats in the remaining groups were treated with combined stimulation of estrogenic and progestational hormone to establish MGH model...
December 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
Xinrong Guo, Jingjing Zhang, Xiaojun Ma, Xiaowei Ma
OBJECTIVE: To explore the correlation between efficacy of electroacupuncture (EA) on mammary gland hyperplasia (MGH) and the regulatory pathway of intercostal nerve. METHODS: Fifty female SD rats were randomly divided into a blank group (group A, 12 rats), a model group (group B, 12 rats), an EA group (group C, 13 rats) and an intercostal nerve transection group (group D, 13 rats). The rats in the group B, group C and group D were prepared into MGH model; after model was successfully prepared, the 7th intercostal nerve was cut off in the group D...
January 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
Giancarlo Corti, Justin L Brown, Negar Rajabi, Dave N McIlroy
The growth efficiency of one dimension(1D) nanostructures via the vapor-liquid-solid process is commonly attributed to parameters such as precursor vapor pressure, substrate temperature, and the choice of the catalyst. The work presented herein is an investigation of the use of silica nanosprings (SN) as a 3D substrate for improving the growth efficiency of SN themselves. Silica nanosprings are a 1D nanomaterial that form a nonwoven structure with optimal geometric characteristics and surface properties that mitigate collisions between growing nanosprings and ripening of the gold catalyst, which should improve SN yield...
January 16, 2018: Nanotechnology
Shylaja Srinivasan, Varinderpal Kaur, Bindu Chamarthi, Katherine R Littleton, Ling Chen, Alisa K Manning, Jordi Merino, Melissa K Thomas, Margo Hudson, Allison Goldfine, Jose C Florez
OBJECTIVE: The rs7903146 T allele in transcription-factor-7-like-2 (TCF7L2) is strongly associated with type 2 diabetes (T2D), but the mechanisms for increased risk remain unclear. We evaluated the physiologic and hormonal effects of TCF7L2 genotype before and after interventions that influence glucose physiology. RESEARCH DESIGN AND METHODS: We genotyped rs7903146 in 608 individuals without diabetes and recorded biochemical data before and after one dose of glipizide (5 mg) on visit 1, and a 75-g oral glucose tolerance test (OGTT) performed after administration of metformin 500 mg twice daily over 2 days...
January 11, 2018: Diabetes Care
Marc Van De Rijn, Sabrina Paganoni, Mark Levine-Weinberg, Katharine Campbell, Amy Swartz Ellrodt, Juan Estrada, Adam B Cohen, Lee H Schwamm, James D Berry
OBJECTIVE: Telemedicine using video televisits is emerging as a means to provide care directly to patients. Here we report our experience using video televisits to provide follow-up care as a part of the Massachusetts General Hospital (MGH) Telemedicine for People with ALS (TelePALS) initiative. METHODS: This was a retrospective chart review of all video televisit encounters conducted by the MGH ALS clinic between September 2014 and January 2016. RESULTS: A total of 97 distinct ALS patients were seen using video televisits...
December 18, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Michael Rauch, Gerard Parkin
The terminal zinc and magnesium hydride compounds, [κ3-TismPriBenz]ZnH and [TismPriBenz]MgH, which feature the tris[(1-isopropylbenzimidazol-2-yl)dimethylsilyl]methyl ligand, react with B(C6F5)3 to afford the ion pairs, {[TismPriBenz]M}[HB(C6F5)3] (M = Zn, Mg), which are rare examples of these metals in trigonal monopyramidal coordination environments. Significantly, in combination with B(C6F5)3, {[TismPriBenz]M}-[HB(C6F5)3] generates catalytic systems for the hydrosilylation of CO2 by R3SiH to afford sequentially the bis(silyl)acetal, H2C(OSiR3)2, and CH4 (R3SiH = PhSiH3, Et3SiH, and Ph3SiH)...
December 11, 2017: Journal of the American Chemical Society
Emily P Hendryx, Béatrice M Rivière, Danny C Sorensen, Craig G Rusin
In this paper, we use the CUR matrix factorization as a means of dimension reduction to identify important subsequences in electrocardiogram (ECG) time series. As opposed to other factorizations typically used in dimension reduction that characterize data in terms of abstract representatives (for example, an orthogonal basis), the CUR factorization describes the data in terms of actual instances within the original data set. Therefore, the CUR characterization can be directly related back to the clinical setting...
December 7, 2017: Journal of Biomedical Informatics
Lara E Lemmerz, Valeri Leich, Daniel Martin, Thomas P Spaniol, Jun Okuda
The magnesium triphenylsilyl complex [(Me3TACD)Mg(SiPh3)] (2) was synthesized from magnesium bis(triphenylsilyl) [Mg(SiPh3)2(THF)2]·THF (1; THF = tetrahydrofuran) and the NNNN-type macrocyclic amidotriamine proligand (Me3TACD)H ((Me3TACD)H = Me3[12]aneN4 = 1,4,7-trimethyl-1,4,7,10-tetraazacyclododecane). Treating 2 with AlR3 (R = Me, Et) gave the magnesium triphenylsilyl complexes with "blocked" amido function [(Me3TACD·AlR3)Mg(SiPh3)] (3a: R = Me; 3b: R = Et). Instead of forming a Mg-H bond upon reaction with dihydrogen or hydrosilanes, 2 and 3a,b underwent rapid silyl-silane exchange with hydrosilanes...
December 1, 2017: Inorganic Chemistry
Wei-Hung Weng, Kavishwar B Wagholikar, Alexa T McCray, Peter Szolovits, Henry C Chueh
BACKGROUND: The medical subdomain of a clinical note, such as cardiology or neurology, is useful content-derived metadata for developing machine learning downstream applications. To classify the medical subdomain of a note accurately, we have constructed a machine learning-based natural language processing (NLP) pipeline and developed medical subdomain classifiers based on the content of the note. METHODS: We constructed the pipeline using the clinical NLP system, clinical Text Analysis and Knowledge Extraction System (cTAKES), the Unified Medical Language System (UMLS) Metathesaurus, Semantic Network, and learning algorithms to extract features from two datasets - clinical notes from Integrating Data for Analysis, Anonymization, and Sharing (iDASH) data repository (n = 431) and Massachusetts General Hospital (MGH) (n = 91,237), and built medical subdomain classifiers with different combinations of data representation methods and supervised learning algorithms...
December 1, 2017: BMC Medical Informatics and Decision Making
A M Dinaux, L G J Leijssen, L G Bordeianou, H Kunitake, R Amri, D L Berger
BACKGROUND: Neo-adjuvant chemoradiation followed by surgery and adjuvant therapy is standard treatment of clinical node positive rectal cancer. Understaging leads to delay in treatment with possible detrimental results. This study analyses effects of understaging stage III rectal cancer on long-term outcomes. METHODS: A consecutive series of patients, operated on in MGH between 2004 and 2015 was included. Outcomes of non-neoadjuvantly treated clinical stage I patients who turned out to have pathological stage III disease and neoadjuvantly treated clinical stage III patients were retrospectively reviewed...
November 8, 2017: American Journal of Surgery
Danny L G Fagundes, Eduardo L França, Michelangelo B Gonzatti, Marilza V C Rugde, Iracema M P Calderon, Adenilda C Honorio-França
The study investigated the role of cytokines IL-4 and IL-17 in the modulation of the functional activity of mononuclear phagocytes in diabetic pregnant women with hyperglycemia. Sixty pregnant women were assigned to the following groups: nondiabetic (ND), mild gestational hyperglycemia (MGH), gestational diabetes mellitus (GDM), or type 2 diabetes mellitus (DM2). The functional activity of phagocytes from maternal blood, cord blood, and colostrum was assessed by determining their superoxide release, phagocytosis, microbicidal activity, and intracellular Ca(2+) release...
November 14, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Diriba B Kumssa, Edward J M Joy, Scott D Young, David W Odee, E Louise Ander, Charles Magare, James Gitu, Martin R Broadley
Moringa oleifera (MO) and M. stenopetala (MS) are two commonly cultivated species of the Moringaceae family. Some households in southern Ethiopia (S. ETH) and Kenya (KEN) plant MS and MO, respectively. The edible parts of these species are rich in amino acids, vitamins and minerals, especially selenium. Despite their nutritional value, Moringa is sometimes considered as a "famine food". The aim of this study was to determine the extent of dietary utilization of these plants by Moringa Growing Households (MGHs)...
2017: PloS One
Toney Thomas Poovelikunnel, Georgina Gethin, Damodar Solanki, Elaine McFadden, Mary Codd, Hilary Humphreys
AIM: To describe the learning experience from a randomised controlled trial (RCT) comparing the efficacy of medical-grade honey (MGH) with mupirocin 2% for the eradication of nasal methicillin-resistant Staphylococcus aureus (MRSA). METHODS: Patients colonised in the nose with MRSA and age ≥18 years were recruited. Participants received either one or two courses of MGH or mupirocin 2%, three times per day for five consecutive days. RESULTS: The proportion of patients who were decolonised after one or two courses of treatment was not significantly different between MGH (18/42; 42...
October 26, 2017: Journal of Hospital Infection
Wenli Cai, Seth M Steinberg, Miriam A Bredella, Gina Basinsky, Bhanusupriya Somarouthu, Scott R Plotkin, Jeffrey Solomon, Brigitte C Widemann, Gordon J Harris, Eva Dombi
OBJECTIVES: Plexiform neurofibromas (PNs) are complex, histologically benign peripheral nerve sheath tumors that are challenging to measure by simple line measurements. Computer-aided volumetric segmentation of PN has become the recommended method to assess response in clinical trials directed at PN. Different methods for volumetric analysis of PN have been developed. The goal of this study is to test the level of agreement in volume measurements and in interval changes using two separate methods of volumetric magnetic resonance imaging analysis...
October 30, 2017: Academic Radiology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"