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https://www.readbyqxmd.com/read/29226678/zinc-and-magnesium-catalysts-for-the-hydrosilylation-of-carbon-dioxide
#1
Michael Rauch, Gerard Parkin
The terminal zinc and magnesium hydride compounds, [κ3-TismPriBenz]ZnH and [TismPriBenz]MgH, which feature the tris[(1-isopropylbenzimidazol-2-yl)dimethylsilyl]methyl ligand, react with B(C6F5)3 to afford the ion pairs, {[TismPriBenz]M}[HB(C6F5)3] (M = Zn, Mg), which are rare examples of these metals in trigonal monopyramidal coordination environments. Significantly, in combination with B(C6F5)3, {[TismPriBenz]M}-[HB(C6F5)3] generates catalytic systems for the hydrosilylation of CO2 by R3SiH to afford sequentially the bis(silyl)acetal, H2C(OSiR3)2, and CH4 (R3SiH = PhSiH3, Et3SiH, and Ph3SiH)...
December 11, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29224855/finding-representative-electrocardiogram-beat-morphologies-with-cur
#2
Emily P Hendryx, Béatrice M Rivière, Danny C Sorensen, Craig G Rusin
In this paper, we use the CUR matrix factorization as a means of dimension reduction to identify important subsequences in electrocardiogram (ECG) time series. As opposed to other factorizations typically used in dimension reduction that characterize data in terms of abstract representatives (for example, an orthogonal basis), the CUR factorization describes the data in terms of actual instances within the original data set. Therefore, the CUR characterization can be directly related back to the clinical setting...
December 7, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29192769/silyl-hydrosilane-exchange-at-a-magnesium-triphenylsilyl-complex-supported-by-a-cyclen-derived-nnnn-type-macrocyclic-ligand
#3
Lara E Lemmerz, Valeri Leich, Daniel Martin, Thomas P Spaniol, Jun Okuda
The magnesium triphenylsilyl complex [(Me3TACD)Mg(SiPh3)] (2) was synthesized from magnesium bis(triphenylsilyl) [Mg(SiPh3)2(THF)2]·THF (1; THF = tetrahydrofuran) and the NNNN-type macrocyclic amidotriamine proligand (Me3TACD)H ((Me3TACD)H = Me3[12]aneN4 = 1,4,7-trimethyl-1,4,7,10-tetraazacyclododecane). Treating 2 with AlR3 (R = Me, Et) gave the magnesium triphenylsilyl complexes with "blocked" amido function [(Me3TACD·AlR3)Mg(SiPh3)] (3a: R = Me; 3b: R = Et). Instead of forming a Mg-H bond upon reaction with dihydrogen or hydrosilanes, 2 and 3a,b underwent rapid silyl-silane exchange with hydrosilanes...
December 1, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29191207/medical-subdomain-classification-of-clinical-notes-using-a-machine-learning-based-natural-language-processing-approach
#4
Wei-Hung Weng, Kavishwar B Wagholikar, Alexa T McCray, Peter Szolovits, Henry C Chueh
BACKGROUND: The medical subdomain of a clinical note, such as cardiology or neurology, is useful content-derived metadata for developing machine learning downstream applications. To classify the medical subdomain of a note accurately, we have constructed a machine learning-based natural language processing (NLP) pipeline and developed medical subdomain classifiers based on the content of the note. METHODS: We constructed the pipeline using the clinical NLP system, clinical Text Analysis and Knowledge Extraction System (cTAKES), the Unified Medical Language System (UMLS) Metathesaurus, Semantic Network, and learning algorithms to extract features from two datasets - clinical notes from Integrating Data for Analysis, Anonymization, and Sharing (iDASH) data repository (n = 431) and Massachusetts General Hospital (MGH) (n = 91,237), and built medical subdomain classifiers with different combinations of data representation methods and supervised learning algorithms...
December 1, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29174165/the-negative-impact-of-understaging-rectal-cancer-patients
#5
A M Dinaux, L G J Leijssen, L G Bordeianou, H Kunitake, R Amri, D L Berger
BACKGROUND: Neo-adjuvant chemoradiation followed by surgery and adjuvant therapy is standard treatment of clinical node positive rectal cancer. Understaging leads to delay in treatment with possible detrimental results. This study analyses effects of understaging stage III rectal cancer on long-term outcomes. METHODS: A consecutive series of patients, operated on in MGH between 2004 and 2015 was included. Outcomes of non-neoadjuvantly treated clinical stage I patients who turned out to have pathological stage III disease and neoadjuvantly treated clinical stage III patients were retrospectively reviewed...
November 8, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29135055/the-modulatory-role-of-cytokines-il-4-and-il-17-in-the-functional-activity-of-phagocytes-in-diabetic-pregnant-women
#6
Danny L G Fagundes, Eduardo L França, Michelangelo B Gonzatti, Marilza V C Rugde, Iracema M P Calderon, Adenilda C Honorio-França
The study investigated the role of cytokines IL-4 and IL-17 in the modulation of the functional activity of mononuclear phagocytes in diabetic pregnant women with hyperglycemia. Sixty pregnant women were assigned to the following groups: nondiabetic (ND), mild gestational hyperglycemia (MGH), gestational diabetes mellitus (GDM), or type 2 diabetes mellitus (DM2). The functional activity of phagocytes from maternal blood, cord blood, and colostrum was assessed by determining their superoxide release, phagocytosis, microbicidal activity, and intracellular Ca(2+) release...
November 14, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29121079/challenges-and-opportunities-for-moringa-growers-in-southern-ethiopia-and-kenya
#7
Diriba B Kumssa, Edward J M Joy, Scott D Young, David W Odee, E Louise Ander, Charles Magare, James Gitu, Martin R Broadley
Moringa oleifera (MO) and M. stenopetala (MS) are two commonly cultivated species of the Moringaceae family. Some households in southern Ethiopia (S. ETH) and Kenya (KEN) plant MS and MO, respectively. The edible parts of these species are rich in amino acids, vitamins and minerals, especially selenium. Despite their nutritional value, Moringa is sometimes considered as a "famine food". The aim of this study was to determine the extent of dietary utilization of these plants by Moringa Growing Households (MGHs)...
2017: PloS One
https://www.readbyqxmd.com/read/29107078/randomised-controlled-trial-of-honey-versus-mupirocin-to-decolonise-patients-with-nasal-colonisation-of-methicillin-resistant-staphylococcus-aureus-and-the-lessons-learned
#8
Toney Thomas Poovelikunnel, Georgina Gethin, Damodar Solanki, Elaine McFadden, Mary Codd, Hilary Humphreys
AIM: To describe the learning experience from a randomised controlled trial (RCT) comparing the efficacy of medical-grade honey (MGH) with mupirocin 2% for the eradication of nasal methicillin-resistant Staphylococcus aureus (MRSA). METHODS: Patients colonised in the nose with MRSA and age ≥18 years were recruited. Participants received either one or two courses of MGH or mupirocin 2%, three times per day for five consecutive days. RESULTS: The proportion of patients who were decolonised after one or two courses of treatment was not significantly different between MGH (18/42; 42...
October 26, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29097016/volumetric-mri-analysis-of-plexiform-neurofibromas-in-neurofibromatosis-type-1-comparison-of-two-methods
#9
Wenli Cai, Seth M Steinberg, Miriam A Bredella, Gina Basinsky, Bhanusupriya Somarouthu, Scott R Plotkin, Jeffrey Solomon, Brigitte C Widemann, Gordon J Harris, Eva Dombi
OBJECTIVES: Plexiform neurofibromas (PNs) are complex, histologically benign peripheral nerve sheath tumors that are challenging to measure by simple line measurements. Computer-aided volumetric segmentation of PN has become the recommended method to assess response in clinical trials directed at PN. Different methods for volumetric analysis of PN have been developed. The goal of this study is to test the level of agreement in volume measurements and in interval changes using two separate methods of volumetric magnetic resonance imaging analysis...
October 30, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29069090/the-meld-plus-a-generalizable-prediction-risk-score-in-cirrhosis
#10
Uri Kartoun, Kathleen E Corey, Tracey G Simon, Hui Zheng, Rahul Aggarwal, Kenney Ng, Stanley Y Shaw
BACKGROUND AND AIMS: Accurate assessment of the risk of mortality following a cirrhosis-related admission can enable health-care providers to identify high-risk patients and modify treatment plans to decrease the risk of mortality. METHODS: We developed a post-discharge mortality prediction model for patients with a cirrhosis-related admission using a population of 314,292 patients who received care either at Massachusetts General Hospital (MGH) or Brigham and Women's Hospital (BWH) between 1992 and 2010...
2017: PloS One
https://www.readbyqxmd.com/read/29036404/the-value-of-prior-knowledge-in-machine-learning-of-complex-network-systems
#11
Dana Ferranti, David Krane, David Craft
Motivation: Our overall goal is to develop machine-learning approaches based on genomics and other relevant accessible information for use in predicting how a patient will respond to a given proposed drug or treatment. Given the complexity of this problem, we begin by developing, testing and analyzing learning methods using data from simulated systems, which allows us access to a known ground truth. We examine the benefits of using prior system knowledge and investigate how learning accuracy depends on various system parameters as well as the amount of training data available...
November 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29028898/diffloop-a-computational-framework-for-identifying-and-analyzing-differential-dna-loops-from-sequencing-data
#12
Caleb A Lareau, Martin J Aryee
Summary: The three-dimensional architecture of DNA within the nucleus is a key determinant of interactions between genes, regulatory elements, and transcriptional machinery. As a result, differences in DNA looping structure are associated with variation in gene expression and cell state. To systematically assess changes in DNA looping architecture between samples, we introduce diffloop, an R/Bioconductor package that provides a suite of functions for the quality control, statistical testing, annotation, and visualization of DNA loops...
September 29, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28986454/validation-of-polygenic-scores-for-qt-interval-in-clinical-populations
#13
Michael A Rosenberg, Steven A Lubitz, Honghuang Lin, Gulum Kosova, Victor M Castro, Paul Huang, Patrick T Ellinor, Roy H Perlis, Christopher Newton-Cheh
BACKGROUND: Polygenic risk scores (PGS) enable rapid estimation of genome-wide susceptibility for traits, which may be useful in clinical settings, such as prediction of QT interval. In this study, we sought to validate PGS for QT interval in 2 real-world cohorts of European ancestry (EA) and African ancestry (AA). METHODS AND RESULTS: Two thousand nine hundred and fifteen participants of EA and 366 of AA in the MGH CAMP study (Cardiology and Metabolic Patient) were genotyped on a genome-wide array and imputed to the 1000 Genomes reference panel...
October 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28920518/the-indirect-costs-of-underfunding-foreign-partners-in-global-health-research-a-case-study
#14
Johanna T Crane, Irene Andia Biraro, Tamer M Fouad, Yap Boum, David R Bangsberg
This study of a global health research partnership assesses how U.S. fiscal administrative policies impact capacity building at foreign partner institutions. We conducted a case study of a research collaboration between Mbarara University of Science and Technology (MUST) in Mbarara, Uganda, and originally the University of California San Francisco (UCSF), but now Massachusetts General Hospital (MGH). Our case study is based on three of the authors' experiences directing and working with this partnership from its inception in 2003 through 2015...
September 16, 2017: Global Public Health
https://www.readbyqxmd.com/read/28903787/a-preliminary-investigation-of-metacognitive-therapy-and-habit-reversal-as-a-treatment-for-trichotillomania
#15
Hossein Shareh
BACKGROUND: Not all patients suffering from trichotillomania (TTM) recover completely using CBT and of those that do, only a few maintain their recovery over time. AIMS: The purpose of the present study was to investigate the effectiveness of metacognitive methods combined with habit reversal (MCT/HRT) in trichotillomania with a relatively long-term follow-up. METHOD: A case series (n = 8) and a randomized wait-list controlled trial (n = 34) design were conducted in this study...
September 14, 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/28901762/synthesis-structure-and-reactivity-of-a-terminal-magnesium-hydride-compound-with-a-carbatrane-motif-tism-pr-i-benz-mgh-a-multifunctional-catalyst-for-hydrosilylation-and-hydroboration
#16
Michael Rauch, Serge Ruccolo, Gerard Parkin
The tris[(1-isopropylbenzimidazol-2-yl)dimethylsilyl)]methyl ligand, [Tism(Pr(i)Benz)], has been employed to form the magnesium carbatrane compound, [Tism(Pr(i)Benz)]MgH, which possesses a terminal hydride ligand. Specifically, [Tism(Pr(i)Benz)]MgH is obtained via the reaction of [Tism(Pr(i)Benz)]MgMe with PhSiH3. The reactivity of [Tism(Pr(i)Benz)]MgMe and [Tism(Pr(i)Benz)]MgH allows access to a variety of other structurally characterized carbatrane derivatives, including [Tism(Pr(i)Benz)]MgX [X = F, Cl, Br, I, SH, N(H)Ph, CH(Me)Ph, O2CMe, S2CMe]...
September 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28862107/collateral-scoring-on-ct-angiogram-must-evaluate-phase-and-regional-pattern
#17
Colin Casault, Abdulaziz S Al Sultan, Anurag Trivedi, Sung Il Sohn, Emmad Qazi, Matthew Bokyo, Mohammed Almekhlafi, Christopher d'Esterre, Mayank Goyal, Andrew M Demchuk, Bijoy K Menon
PURPOSE: We measured anterior cerebral artery (ACA)-middle cerebral artery (MCA) and posterior cerebral artery (PCA)-MCA pial filling on single-phase computed tomography angiograms (sCTAs) in acute ischemic stroke and correlate with the CTA-based Massachusetts General Hospital (MGH) and digital subtraction angiography (DSA)-based American Society of Interventional and Therapeutic Neuroradiology (ASITN) score. METHODS: Patients with acute stroke and M1 MCA±intracranial internal carotid artery occlusion on baseline CTA were included...
September 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28847013/do-less-harm-evaluating-hiv-programmatic-alternatives-in-response-to-cutbacks-in-foreign-aid
#18
Rochelle P Walensky, Ethan D Borre, Linda-Gail Bekker, Emily P Hyle, Gregg S Gonsalves, Robin Wood, Serge P Eholié, Milton C Weinstein, Xavier Anglaret, Kenneth A Freedberg, A David Paltiel
Background: Resource-limited nations must consider their response to potential contractions in international support for HIV programs. Objective: To evaluate the clinical, epidemiologic, and budgetary consequences of alternative HIV program scale-back strategies in 2 recipient nations, the Republic of South Africa (RSA) and Côte d'Ivoire (CI). Design: Model-based comparison between current standard (CD4 count at presentation of 0.260 × 109 cells/L, universal antiretroviral therapy [ART] eligibility, and 5-year retention rate of 84%) and scale-back alternatives, including reduced HIV detection, no ART or delayed initiation (when CD4 count is <0...
November 7, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28816563/highlighting-the-differences-in-post-traumatic-symptoms-between-patients-with-complicated-and-uncomplicated-mild-traumatic-brain-injury-and-injured-controls
#19
J Julien, S Tinawi, K Anderson, L C Frenette, H Audrit, M C Ferland, M Feyz, E De Guise
OBJECTIVE: The goal of the current study is to explore the difference in acute post-concussive symptoms (PCS), headaches, sleep and mood complaints between groups of patients with complicated and uncomplicated mild traumatic brain injuries (mTBIs) and a comparable group of injured controls. Interactions among the following four factors were studied: presence of (1) PCS; (2) headaches; (3) sleep disorders; and (4) psychological status. METHODS: A total of 198 patients, followed at the outpatient mTBI clinic of the MUHC-MGH, completed questionnaires and a brief neurological assessment two weeks post-trauma...
2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28810177/use-of-atypical-antipsychotics-in-pregnancy-and-maternal-gestational-diabetes
#20
Alice Panchaud, Sonia Hernandez-Diaz, Marlene P Freeman, Adele C Viguera, Sarah C MacDonald, Alexandra Z Sosinsky, Lee S Cohen
BACKGROUND: Second generation antipsychotic medications (SGAs) are widely used by reproductive-age women to treat a number of psychiatric illnesses. Some SGAs have been associated with an increased risk of developing diabetes, although information regarding their diabetogenic effect in pregnant women is scarce. OBJECTIVE: To evaluate the risk of gestational diabetes (GDM) among women treated with SGA. METHOD: The Massachusetts General Hospital (MGH) National Pregnancy Registry for Atypical Antipsychotics (NPRAA) collects data on drug use, pregnancy outcomes, and other characteristics from pregnant women, ages 18-45 years, using 3 phone interviews conducted at (1) enrollment during pregnancy, (2) 7 months' gestation, and (3) 2-3 months postpartum...
December 2017: Journal of Psychiatric Research
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