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Jinpin Li, Di Qiu, Zezhi Chen, Weiwei Du, Jingli Liu, Xuean Mo
Myasthenia gravis (MG) is a B cell-mediated and T cell-dependent autoimmune disease. Thymic hyperplasia has great significance for MG pathogenesis and treatment. MicroRNAs (miRNAs) are a newly recognized type of gene expression regulatory factor that regulate gene expression at the post-transcriptional level. Additionally, miRNAs are involved in immune regulation of the thymus and the occurrence and development of autoimmune diseases. In this study, we found 33 miRNAs that were significantly dysregulated in thymic tissues from MG patients with thymus hyperplasia (MGH) compared with thymic tissues from normal controls using a miRNA microarray chip...
April 4, 2018: Journal of Neuroimmunology
Yusuke Matsui, Yosuke Funato, Hiromi Imamura, Hiroaki Miki, Shin Mizukami, Kazuya Kikuchi
Mg2+ plays important roles in many physiological processes. However, the underlying molecular mechanisms, especially in the apoptotic pathway, remain unclear due to the diffusion of Mg2+ probes, which hinders long-term imaging in specific organelles. We developed an immobilized Mg2+ probe, MGH, which is covalently conjugated with the HaloTag protein in various organelles. HaloTag-coupled MGH enabled long-term imaging of intracellular local Mg2+ dynamics for 24 h. To exploit this remarkable property, MGH was applied to the investigation of intracellular Mg2+ dynamics during apoptosis...
December 1, 2017: Chemical Science
Jeeheh Oh, Maggie Makar, Christopher Fusco, Robert McCaffrey, Krishna Rao, Erin E Ryan, Laraine Washer, Lauren R West, Vincent B Young, John Guttag, David C Hooper, Erica S Shenoy, Jenna Wiens
OBJECTIVE An estimated 293,300 healthcare-associated cases of Clostridium difficile infection (CDI) occur annually in the United States. To date, research has focused on developing risk prediction models for CDI that work well across institutions. However, this one-size-fits-all approach ignores important hospital-specific factors. We focus on a generalizable method for building facility-specific models. We demonstrate the applicability of the approach using electronic health records (EHR) from the University of Michigan Hospitals (UM) and the Massachusetts General Hospital (MGH)...
April 2018: Infection Control and Hospital Epidemiology
Suheyla Cetin Karayumak, Evren Özarslan, Gozde Unal
Characterization of anisotropy via diffusion MRI reveals fiber crossings in a substantial portion of voxels within the white-matter (WM) regions of the human brain. A considerable number of such voxels could exhibit asymmetric features such as bends and junctions. However, widely employed reconstruction methods yield symmetric Orientation Distribution Functions (ODFs) even when the underlying geometry is asymmetric. In this paper, we employ inter-voxel directional filtering approaches through a cone model to reveal more information regarding the cytoarchitectural organization within the voxel...
March 14, 2018: Magnetic Resonance Imaging
Wei Zhang, Guang Xu, Ying Cheng, Lingjuan Chen, Quan Huo, Suyan Liu
The sulfide catalyst is a subject of great interest in developing a MgH2 system as a potential hydrogen storage medium. In this work, FeS2 micro-spheres were successfully prepared by the surfactant-assisted solvothermal method, and later were ball milled with MgH2 to fabricate the MgH2 -16.7 wt% FeS2 composite. FeS2 addition could dramatically improve both the hydrogenation and dehydrogenation kinetics, and lower the dehydrogenation temperature of MgH2 as well. The MgH2 -16.7 wt% FeS2 composite could absorb 3...
March 14, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Charles M Laymon, Davneet S Minhas, Carl R Becker, Cristy Matan, Matthew J Oborski, Julie C Price, James M Mountz
PURPOSE: In dual modality positron emission tomography (PET)/magnetic resonance imaging (MRI), attenuation correction (AC) methods are continually improving. Although a new AC can sometimes be generated from existing MR data, its application requires a new reconstruction. We evaluate an approximate 2D projection method that allows offline image-based reprocessing. PROCEDURE: 2-Deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) brain scans were acquired (Siemens HR+) for six subjects...
February 27, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Angela R Shih, Gregory M Cote, Ivan Chebib, Edwin Choy, Thomas DeLaney, Vikram Deshpande, Francis J Hornicek, Ruoyu Miao, Joseph H Schwab, G Petur Nielsen, Yen-Lin Chen
Chordoma is a rare malignant tumor of bone with high morbidity and mortality. Recently, aggressive pediatric poorly differentiated chordoma with SMARCB1 loss has been described. This study summarizes the clinicopathologic features of poorly differentiated chordoma with SMARCB1 loss in the largest series to date. A search of records between 1990-2017 at MGH identified 19 patients with poorly differentiated chordoma. Immunohistochemical stains were evaluated. Kaplan-Meier survival statistics and log-rank (Mantel Cox) tests compared survival with other subtypes...
February 26, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Jiuchuang Yuan, Di He, Shufen Wang, Maodu Chen, Keli Han
The global diabatic potential energy surfaces (PESs) of the MgH2 + system, which can be used to study the dynamics of the Mg+ (3p2 P) + H2 (X1 Σ) → MgH+ (X1 Σ+ ) + H(2 S) reaction, are structured for the first time. The diabatic PESs are correlated with the ground state 12 A' and the first excited state 22 A'. The multi-reference configuration interaction method and the VQZ basis set are used in ab initio calculations, and diabatic potential energies are calculated based on the molecular properties of the dipole moment...
February 19, 2018: Physical Chemistry Chemical Physics: PCCP
Hao-Tian Li, Hong-Hong Liu, Yu-Xue Yang, Tao Wang, Xue-Lin Zhou, Yang Yu, Su-Na Li, Yi Zheng, Ping Zhang, Rui-Lin Wang, Jian-Yu Li, Shi-Zhang Wei, Kun Li, Peng-Yan Li, Li-Qi Qian
As a common disorder that accounts for over 70% of all breast disease cases, mammary gland hyperplasia (MGH) causes a severe problem for the quality of patients' life, and confers an increased risk of breast carcinoma. However, the etiology and pathogenesis of MGH remain unclear, and the safety and efficacy of current western drug therapy for MGH still need to be improved. Therefore, a meta-analysis was conducted by our team to determine whether a TCM formula named Ru-Pi-Xiao in combination with tamoxifen or Ru-Pi-Xiao treated alone can show more prominent therapeutic effects against MGH with fewer adverse reactions than that of tamoxifen...
2018: Frontiers in Pharmacology
Matheus Oliveira da Silva, Marcella Lemos Brettas Carneiro, Joseílma Luciana Neves Siqueira, Sônia Nair Báo, Aparecido Ribeiro de Souza
In this study, we report the synthesis and characterization of a new rhodium(II) succinate complex (Rh2(suc)4) and its immobilization on lauric acid bilayer-coated maghemite nanoparticles (MGH-2L/Rh2(suc)4) and subsequent adsorption with bovine serum albumin (MGH-2L/Rh2(suc)4/BSA). Rh2(suc)4 has been characterized by elemental analysis, potentiometric titration, TGA, MS, FTIR and UV-Vis analysis. The maghemite phase was confirmed by XRD, and a diameter of 10 nm was obtained by Sherrer equation. The VSM experiment showed superparamagnetic properties...
June 1, 2018: Journal of Nanoscience and Nanotechnology
Mercy Abbey, Seth Kwaku Afagbedzi, Jane Afriyie-Mensah, David Antwi-Agyei, Kirchuffs Atengble, Ebenezer Badoe, James Batchelor, Eric S Donkor, Reuben Esena, Bamenla Q Goka, Michael G Head, Appiah-Korang Labi, Edmund Nartey, Isabella Sagoe-Moses, Edem M A Tette
Despite the high mortality, pneumonia retains a relatively low profile among researchers, funders and policymakers. Here we reflect on the problems and priorities of pneumonia in Ghana, briefly review the evidence base and reflect upon in-person discussions between Southampton-based authors MGH and JB and academic, clinical and policy colleagues in Ghana. The discussions took place in Accra in August 2017.
February 1, 2018: International Health
Ashkan Ghanbarzadeh Dagheyan, Ali Molaei, Richard Obermeier, Andrew Westwood, Aida Martinez, Jose Angel Martinez Lorenzo
Accurate and early detection of breast cancer is of high importance, as it is directly associated with the patients' overall well-being during treatment and their chances of survival. Uncertainties in current breast imaging methods can potentially cause two main problems: (1) missing newly formed or small tumors; and (2) false alarms, which could be a source of stress for patients. A recent study at the Massachusetts General Hospital (MGH) indicates that using Digital Breast Tomosynthesis (DBT) can reduce the number of false alarms, when compared to conventional mammography...
January 25, 2018: Sensors
Luca Pinello, Rick Farouni, Guo-Cheng Yuan
Motivation: With the increasing amount of genomic and epigenomic data in the public domain, a pressing challenge is to integrate these data to investigate the role of epigenetic mechanisms in regulating gene expression and maintenance of cell-identity. To this end, we have implemented a computational pipeline to systematically study epigenetic variability and uncover regulatory DNA sequences. Results: Haystack is a bioinformatics pipeline to identify hotspots of epigenetic variability across different cell-types, cell-type specific cis-regulatory elements, and associated transcription factors...
January 17, 2018: Bioinformatics
Xian Zhao, Mi Hou
OBJECTIVE: To observe the effects of acupuncture combined with Rule granule on breast tissue, prolactin(PRL) and prolactin receptor (PRLR) expression in rats with mammary gland hyperplasia (MGH), and to explore its action mechanism to provide reference for clinical treatment of MGH. METHODS: Fifty-five female SD rats were randomly divided into a blank group, a model group, an acupuncture group, a Rule granule group and a combination group. Except the blank group, the rats in the remaining groups were treated with combined stimulation of estrogenic and progestational hormone to establish MGH model...
December 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
Xinrong Guo, Jingjing Zhang, Xiaojun Ma, Xiaowei Ma
OBJECTIVE: To explore the correlation between efficacy of electroacupuncture (EA) on mammary gland hyperplasia (MGH) and the regulatory pathway of intercostal nerve. METHODS: Fifty female SD rats were randomly divided into a blank group (group A, 12 rats), a model group (group B, 12 rats), an EA group (group C, 13 rats) and an intercostal nerve transection group (group D, 13 rats). The rats in the group B, group C and group D were prepared into MGH model; after model was successfully prepared, the 7th intercostal nerve was cut off in the group D...
January 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
Giancarlo Corti, Justin Brown, Negar Rajabi, D N McIlroy
The growth efficiency of one-dimension (1D) nanostructures via the vapor-liquid-solid process is commonly attributed to parameters such as precursor vapor pressure, substrate temperature, and the choice of the catalyst. The work presented herein is an investigation of the use of silica nanosprings (SNs) as a 3D substrate for improving the growth efficiency of SN themselves. SNs are a 1D nanomaterial that form a nonwoven structure with optimal geometric characteristics and surface properties that mitigate collisions between growing nanosprings and ripening of the gold catalyst, which should improve SN yield...
March 16, 2018: Nanotechnology
Shylaja Srinivasan, Varinderpal Kaur, Bindu Chamarthi, Katherine R Littleton, Ling Chen, Alisa K Manning, Jordi Merino, Melissa K Thomas, Margo Hudson, Allison Goldfine, Jose C Florez
OBJECTIVE: The rs7903146 T allele in transcription factor 7 like 2 ( TCF7L2 ) is strongly associated with type 2 diabetes (T2D), but the mechanisms for increased risk remain unclear. We evaluated the physiologic and hormonal effects of TCF7L2 genotype before and after interventions that influence glucose physiology. RESEARCH DESIGN AND METHODS: We genotyped rs7903146 in 608 individuals without diabetes and recorded biochemical data before and after 1 ) one dose of glipizide (5 mg) on visit 1 and 2 ) a 75-g oral glucose tolerance test (OGTT) performed after administration of metformin 500 mg twice daily over 2 days...
March 2018: Diabetes Care
Marc Van De Rijn, Sabrina Paganoni, Mark Levine-Weinberg, Katharine Campbell, Amy Swartz Ellrodt, Juan Estrada, Adam B Cohen, Lee H Schwamm, James D Berry
OBJECTIVE: Telemedicine using video televisits is emerging as a means to provide care directly to patients. Here we report our experience using video televisits to provide follow-up care as a part of the Massachusetts General Hospital (MGH) Telemedicine for People with ALS (TelePALS) initiative. METHODS: This was a retrospective chart review of all video televisit encounters conducted by the MGH ALS clinic between September 2014 and January 2016. RESULTS: A total of 97 distinct ALS patients were seen using video televisits...
February 2018: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Michael Rauch, Gerard Parkin
The terminal zinc and magnesium hydride compounds, [κ3 -TismPri Benz ]ZnH and [TismPri Benz ]MgH, which feature the tris[(1-isopropylbenzimidazol-2-yl)dimethylsilyl]methyl ligand, react with B(C6 F5 )3 to afford the ion pairs, {[TismPri Benz ]M}[HB(C6 F5 )3 ] (M = Zn, Mg), which are rare examples of these metals in trigonal monopyramidal coordination environments. Significantly, in combination with B(C6 F5 )3 , {[TismPri Benz ]M}-[HB(C6 F5 )3 ] generates catalytic systems for the hydrosilylation of CO2 by R3 SiH to afford sequentially the bis(silyl)acetal, H2 C(OSiR3 )2 , and CH4 (R3 SiH = PhSiH3 , Et3 SiH, and Ph3 SiH)...
December 20, 2017: Journal of the American Chemical Society
Emily P Hendryx, Béatrice M Rivière, Danny C Sorensen, Craig G Rusin
In this paper, we use the CUR matrix factorization as a means of dimension reduction to identify important subsequences in electrocardiogram (ECG) time series. As opposed to other factorizations typically used in dimension reduction that characterize data in terms of abstract representatives (for example, an orthogonal basis), the CUR factorization describes the data in terms of actual instances within the original data set. Therefore, the CUR characterization can be directly related back to the clinical setting...
January 2018: Journal of Biomedical Informatics
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