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https://www.readbyqxmd.com/read/27926742/modeling-deficits-from-early-auditory-information-processing-to-psychosocial-functioning-in-schizophrenia
#1
Michael L Thomas, Michael F Green, Gerhard Hellemann, Catherine A Sugar, Melissa Tarasenko, Monica E Calkins, Tiffany A Greenwood, Raquel E Gur, Ruben C Gur, Laura C Lazzeroni, Keith H Nuechterlein, Allen D Radant, Larry J Seidman, Alexandra L Shiluk, Larry J Siever, Jeremy M Silverman, Joyce Sprock, William S Stone, Neal R Swerdlow, Debby W Tsuang, Ming T Tsuang, Bruce I Turetsky, David L Braff, Gregory A Light
Importance: Neurophysiologic measures of early auditory information processing (EAP) are used as endophenotypes in genomic studies and biomarkers in clinical intervention studies. Research in schizophrenia has established correlations among measures of EAP, cognition, clinical symptoms, and functional outcome. Clarifying these associations by determining the pathways through which deficits in EAP affect functioning would suggest when and where to therapeutically intervene. Objectives: To characterize the pathways from EAP to outcome and to estimate the extent to which enhancement of basic information processing might improve cognition and psychosocial functioning in schizophrenia...
December 7, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27922085/diversity-of-major-urinary-proteins-mups-in-wild-house-mice
#2
Michaela Thoß, Viktoria Enk, Hans Yu, Ingrid Miller, Kenneth C Luzynski, Boglarka Balint, Steve Smith, Ebrahim Razzazi-Fazeli, Dustin J Penn
Major urinary proteins (MUPs) are often suggested to be highly polymorphic, and thereby provide unique chemical signatures used for individual and genetic kin recognition; however, studies on MUP variability have been lacking. We surveyed populations of wild house mice (Mus musculus musculus), and examined variation of MUP genes and proteins. We sequenced several Mup genes (9 to 11 loci) and unexpectedly found no inter-individual variation. We also found that microsatellite markers inside the MUP cluster show remarkably low levels of allelic diversity, and significantly lower than the diversity of markers flanking the cluster or other markers in the genome...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27913160/psychological-well-being-and-mental-health-recovery-in-the-nimh-raise-early-treatment-program
#3
Julia Browne, David L Penn, Piper S Meyer-Kalos, Kim T Mueser, Sue E Estroff, Mary F Brunette, Christoph U Correll, James Robinson, Robert A Rosenheck, Nina Schooler, Delbert G Robinson, Jean Addington, Patricia Marcy, John M Kane
Recovery-oriented practices that promote client-centered care, collaboration, and functional outcome have been recommended to improve treatment engagement, especially for individuals with serious mental illness (SMI). Psychological well-being (PWB) is related to recovery and refers to experiencing purpose and meaning in life through realizing one's potential. The recently completed Recovery After an Initial Schizophrenia Episode Early Treatment Program (RAISE ETP) study sought to improve quality of life, functional outcome, and well-being in individuals with first episode psychosis (FEP)...
November 29, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27911024/the-clinical-importance-of-pulsatile-flow-in-extracorporeal-life-support-the-penn-state-health-approach
#4
Akif Ündar, Shigang Wang, Jenelle M Izer, Joseph B Clark, Allen R Kunselman, Sunil Patel, Kaitlyn Shank, Elizabeth Profeta, Ronald P Wilson, Petr Ostadal
No abstract text is available yet for this article.
December 2016: Artificial Organs
https://www.readbyqxmd.com/read/27898930/effects-of-roughage-inclusion-and-particle-size-on-performance-and-rumination-behavior-of-finishing-beef-steers
#5
W W Gentry, C P Weiss, C M Meredith, F T McCollum, N A Cole, J S Jennings
Roughage is typically mechanically processed to increase digestibility and improve handling and mixing characteristics in beef cattle finishing diets. Roughage is fed to promote ruminal health and decrease digestive upset, but inclusion in finishing diets is limited due to the cost per unit of energy. Rumination behavior may be a means to standardize roughage in beef cattle finishing diets, and increasing particle size of roughage may allow a decrease in roughage inclusion without sacrificing animal performance...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27897004/identifying-genetic-associations-with-variability-in-metabolic-health-and-blood-count-laboratory-values-diving-into-the-quantitative-traits-by-leveraging-longitudinal-data-from-an-ehr
#6
Shefali S Verma, Anastasia M Lucas, Daniel R Lavage, Joseph B Leader, Raghu Metpally, Sarathbabu Krishnamurthy, Frederick Dewey, Ingrid Borecki, Alexander Lopez, John Overton, John Penn, Jeffrey Reid, Sarah A Pendergrass, Gerda Breitwieser, Marylyn D Ritchie
A wide range of patient health data is recorded in Electronic Health Records (EHR). This data includes diagnosis, surgical procedures, clinical laboratory measurements, and medication information. Together this information reflects the patient's medical history. Many studies have efficiently used this data from the EHR to find associations that are clinically relevant, either by utilizing International Classification of Diseases, version 9 (ICD-9) codes or laboratory measurements, or by designing phenotype algorithms to extract case and control status with accuracy from the EHR...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27895987/characterization-of-fiber-optic-light-delivery-and-light-induced-temperature-changes-in-a-rodent-brain-for-precise-optogenetic-neuromodulation
#7
Younghoon Shin, Minsu Yoo, Hyung-Sun Kim, Sung-Ki Nam, Hyoung-Ihl Kim, Sun-Kyu Lee, Sohee Kim, Hyuk-Sang Kwon
Understanding light intensity and temperature increase is of considerable importance in designing or performing in vivo optogenetic experiments. Our study describes the optimal light power at target depth in the rodent brain that would maximize activation of light-gated ion channels while minimizing temperature increase. Monte Carlo (MC) simulations of light delivery were used to provide a guideline for suitable light power at a target depth. In addition, MC simulations with the Pennes bio-heat model using data obtained from measurements with a temperature-measuring cannula having 12...
November 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27890658/magnetic-mapping-of-iron-in-rodent-spleen
#8
Angela R Blissett, Brooke Ollander, Brittany Penn, Dana M McTigue, Gunjan Agarwal
Evaluation of iron distribution and density in biological tissues is important to understand the pathogenesis of a variety of diseases and the fate of exogenously administered iron-based carriers and contrast agents. Iron distribution in tissues is typically characterized via histochemical (Perl's) stains or immunohistochemistry for ferritin, the major iron storage protein. A more accurate mapping of iron can be achieved via ultrastructural transmission electron microscopy (TEM) based techniques, which involve stringent sample preparation conditions...
November 25, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/27888982/contraceptive-choices-and-preferences-in-a-cohort-of-women-with-cystic-fibrosis
#9
Andrea Hsu Roe, Sarah A Traxler, Denis Hadjiliadis, Mary D Sammel, Courtney A Schreiber
OBJECTIVES: As life expectancy for women with cystic fibrosis (CF) improves, reproductive decision-making is becoming increasingly relevant. We sought to characterize fertility intentions, contraceptive use, and preferences among adult females with CF. STUDY DESIGN: We conducted a cross-sectional survey of contraceptive use and preferences in reproductive-aged women with CF. Subjects were recruited via an electronic mailing list from the Penn Adult Cystic Fibrosis Program...
December 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27888927/thermal-behavior-of-human-eye-in-relation-with-change-in-blood-perfusion-porosity-evaporation-and-ambient-temperature
#10
REVIEW
Aasma Rafiq, M A Khanday
Extreme environmental and physiological conditions present challenges for thermal processes in body tissues including multi-layered human eye. A mathematical model has been formulated in this direction to study the thermal behavior of the human eye in relation with the change in blood perfusion, porosity, evaporation and environmental temperatures. In this study, a comprehensive thermal analysis has been performed on the multi-layered eye using Pennes' bio-heat equation with appropriate boundary and interface conditions...
December 2016: Journal of Thermal Biology
https://www.readbyqxmd.com/read/27881816/hypothermia-treated-neonates-with-hypoxic-ischemic-encephalopathy-optimal-timing-of-quantitative-adc-measurement-to-predict-disease-severity
#11
Yauk K Lee, Alex Penn, Mahesh Patel, Rajul Pandit, Dongli Song, Bo Yoon Ha
To determine the optimal time window for MR imaging with quantitative ADC measurement in neonatal HIE after hypothermia treatment, a retrospective review was performed on consecutive hypothermia-treated term neonates with HIE, with an initial and follow-up MR imaging within the first two weeks of life. Three neuroradiologists categorized each set of MR imaging as normal, mild, moderate or severe HIE based on a consensus review of the serial imaging. The lowest ADC values from the white matter, corpus callosum, and basal ganglia/thalamus were measured...
November 23, 2016: Neuroradiology Journal
https://www.readbyqxmd.com/read/27878470/%C3%AE-2-agonists
#12
Charlotte K Billington, Raymond B Penn, Ian P Hall
History suggests β agonists, the cognate ligand of the β2 adrenoceptor, have been used as bronchodilators for around 5,000 years, and β agonists remain today the frontline treatment for asthma and chronic obstructive pulmonary disease (COPD). The β agonists used clinically today are the products of significant expenditure and over 100 year's intensive research aimed at minimizing side effects and enhancing therapeutic usefulness. The respiratory physician now has a therapeutic toolbox of long acting β agonists to prophylactically manage bronchoconstriction, and short acting β agonists to relieve acute exacerbations...
November 23, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27870046/naive-tadpoles-do-not-recognize-recent-invasive-predatory-fishes-as%C3%A2-dangerous
#13
Attila Hettyey, Kerstin E Thonhauser, Veronika Bókony, Dustin J Penn, Herbert Hoi, Matteo Griggio
Invasive alien predators (IAP) are spreading on a global scale-often with devastating ecological effects. One reason for their success may be that prey species fail to recognize them due to a lack of co-evolutionary history. We performed a comprehensive test of this "prey naiveté" hypothesis using a novel approach: we tested whether predator-naive tadpoles of the agile frog (Rana dalmatina) display antipredator behavior upon encountering chemical cues produced by native, invasive (established or recent) or allopatric fishes (four perciforms, four siluriforms, and two cypriniforms)...
November 2016: Ecology
https://www.readbyqxmd.com/read/27860369/factor-structure-of-therapist-fidelity-to-individual-resiliency-training-in-the-recovery-after-an-initial-schizophrenia-episode-early-treatment-program
#14
Julia Browne, Alexandra N Edwards, David L Penn, Piper S Meyer-Kalos, Jennifer D Gottlieb, Paul Julian, Kelsey Ludwig, Kim T Mueser, John M Kane
BACKGROUND: Evidence-based approaches and early intervention have improved the long-term prognosis of individuals with schizophrenia. However, little is known about the therapeutic processes involved in individual therapy in first-episode psychosis. A comprehensive psychosocial/psychiatric programme for this population, NAVIGATE, includes an individual therapy component, individual resiliency training (IRT). Fidelity of clinicians' adherence to the IRT protocol has been collected to ensure proper implementation of this manual-based intervention...
November 9, 2016: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/27857851/parameter-estimation-of-breast-tumour-using-dynamic-neural-network-from-thermal-pattern
#15
Elham Saniei, Saeed Setayeshi, Mohammad Esmaeil Akbari, Mitra Navid
This article presents a new approach for estimating the depth, size, and metabolic heat generation rate of a tumour. For this purpose, the surface temperature distribution of a breast thermal image and the dynamic neural network was used. The research consisted of two steps: forward and inverse. For the forward section, a finite element model was created. The Pennes bio-heat equation was solved to find surface and depth temperature distributions. Data from the analysis, then, were used to train the dynamic neural network model (DNN)...
November 2016: Journal of Advanced Research
https://www.readbyqxmd.com/read/27853428/goal-directed-worry-rules-are-associated-with-distinct-patterns-of-amygdala-functional-connectivity-and-vagal-modulation-during-perseverative-cognition
#16
Frances Meeten, Graham C L Davey, Elena Makovac, David R Watson, Sarah N Garfinkel, Hugo D Critchley, Cristina Ottaviani
Excessive and uncontrollable worry is a defining feature of Generalized Anxiety Disorder (GAD). An important endeavor in the treatment of pathological worry is to understand why some people are unable to stop worrying once they have started. Worry perseveration is associated with a tendency to deploy goal-directed worry rules (known as "as many as can" worry rules; AMA). These require attention to the goal of the worry task and continuation of worry until the aims of the "worry bout" are achieved. This study examined the association between the tendency to use AMA worry rules and neural and autonomic responses to a perseverative cognition induction...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27806383/transplacental-passage-of-acetaminophen-in-term-pregnancy
#17
Joshua F Nitsche, Avinash S Patil, Loralie J Langman, Hannah J Penn, Douglas Derleth, William J Watson, Brian C Brost
Objective The objective of this study was to determine the maternal and fetal pharmacokinetic (PK) profiles of acetaminophen after administration of a therapeutic oral dose. Study Design After obtaining Institutional Review Board approval and their written informed consent, pregnant women were given a single oral dose (1,000 mg) of acetaminophen upon admission for scheduled cesarean delivery. Maternal venous blood and fetal cord blood were obtained at the time of delivery and acetaminophen levels were measured using gas chromatography-mass spectroscopy...
November 2, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27805950/three-year-md-programs-perspectives-from-the-consortium-of-accelerated-medical-pathway-programs-campp
#18
Joan Cangiarella, Tonya Fancher, Betsy Jones, Lisa Dodson, Shou Ling Leong, Matthew Hunsaker, Robert Pallay, Robert Whyte, Amy Holthouser, Steven B Abramson
In the last decade, there has been renewed interest in three-year MD pathway programs. In 2015, with support from the Josiah Macy Jr., Foundation, eight North American medical schools with three-year accelerated medical pathway programs formed the Consortium of Accelerated Medical Pathway Programs (CAMPP). The schools are two campuses of the Medical College of Wisconsin; McMaster University Michael G. DeGroote School of Medicine; Mercer University School of Medicine; New York University School of Medicine; Penn State College of Medicine; Texas Tech University Health Sciences Center School of Medicine; University of California, Davis School of Medicine; and University of Louisville School of Medicine...
November 1, 2016: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/27798477/thermal-response-of-human-skin-to-microwave-energy-a-critical-review
#19
Kenneth R Foster, Marvin C Ziskin, Quirino Balzano
This is a review/modeling study of heating of tissue by microwave energy in the frequency range from 3 GHz through the millimeter frequency range (30-300 GHz). The literature was reviewed to identify studies that reported RF-induced increases in skin temperature. A simple thermal model, based on a simplified form of Pennes' bioheat equation (BHTE), was developed, using parameter values taken from the literature with no further adjustment. The predictions of the model were in excellent agreement with available data...
December 2016: Health Physics
https://www.readbyqxmd.com/read/27795949/outcome-of-repair-of-chronic-tear-of-the-pectoralis-major-using-corkscrew-suture-anchors-by-box-suture-sliding-technique
#20
Deepak Joshi, Jitesh Kumar Jain, Deepak Chaudhary, Utkarsh Singh, Vineet Jain, Ajay Lal
AIM: To assess the functional and clinical results of repair of chronic tears of pectoralis major using corkscrew and sliding suture technique. METHODS: In this retrospective study, we reviewed the results of pectoralis major repair in 11 chronic cases (> 6 wk) done between September 2011 and December 2014 at our institute. In all cases repair was done by same surgeon using corkscrew suture anchors and box suture sliding technique. At 6 mo, after surgery magnetic resonance imaging was done to see the integrity of the repair...
October 18, 2016: World Journal of Orthopedics
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