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https://www.readbyqxmd.com/read/28097781/an-analysis-of-oncotype-dx-recurrence-scores-and-clinicopathologic-characteristics-in-invasive-lobular-breast-cancer
#1
Jesse L Felts, Junjia Zhu, Bing Han, Stanley J Smith, Cristina I Truica
The Oncotype DX breast cancer assay (Genomic Health, Redwood City, CA) is increasingly being used to guide treatment decisions for patients with early stage, hormone-positive, Her-2-negative breast cancer. The utility of the Oncotype DX in decision making for treatment of invasive lobular carcinoma (ILC) has not been investigated as the results reported by Genomic Health are largely in a population with invasive ductal carcinoma (IDC). The authors hypothesized that the Oncotype DX recurrence score (RS) distribution for ILC is different than that for IDC...
January 18, 2017: Breast Journal
https://www.readbyqxmd.com/read/28095557/the-photodynamic-therapy-experience-of-a-high-volume-laser-and-dermatologic-surgery-center
#2
David E Orbuch, Lauren Penn, Bradley S Bloom, Jeremy A Brauer, Daniel B Shin, Joshua Greenbaum, Leonard J Bernstein, Elliot T Weiss, Robert T Anolik, Roy G Geronemus
BACKGROUND: Photodynamic therapy (PDT) is an FDA approved treatment for actinic keratoses (AK's) although multiple off-label indi- cations are reported. Despite frequent use for AK's, no clear consensus exists regarding protocols for overall treatment parameters. METHODS: Retrospective chart review of 1,491 subjects who underwent PDT between 2007 and 2011 at a high volume laser surgery center. Demographic information, clinical history, treatment data, and subsequent diagnosis of skin cancers were recorded...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28094169/a-12-week-randomized-controlled-trial-of-twice-daily-intranasal-oxytocin-for-social-cognitive-deficits-in-people-with-schizophrenia
#3
L Fredrik Jarskog, Cort A Pedersen, Jacqueline L Johnson, Robert M Hamer, Shane W Rau, Tonya Elliott, David L Penn
Social cognition is impaired in people with schizophrenia and these deficits are strongly correlated with social functioning. Oxytocin is a hypothalamic peptide that contributes to maternal infant bonding and has diverse pro-social effects in adults. This study tested the hypothesis that 12weeks of intranasal oxytocin will improve social cognitive function in outpatients with schizophrenia and schizoaffective disorder. Sixty-eight eligible participants were randomized to oxytocin (24IU twice daily) or placebo...
January 13, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28066685/linoleic-acid-is-a-diabetes-relevant-stimulator-of-retinal-inflammation-in-human-retinal-muller-cells-and-microvascular-endothelial-cells
#4
Megan E Capozzi, Gary W McCollum, David B Cousins, John S Penn
OBJECTIVE: To determine the effect of oleic acid and linoleic acid on the production and secretion of specific diabetic retinopathy- (DR-) related cytokines: vascular endothelial growth factor (VEGF), interleukin-6 (IL-6), and interleukin-8 (IL-8) by human retinal glial cells, retinal endothelial cells, and retinal pigment epithelial cells. These expression profiles will be compared to those obtained by treatment of the same cell types with elevated D-glucose, a diabetes-relevant stimulus often used in retinal cell culture experiments...
December 2016: Journal of Diabetes & Metabolism
https://www.readbyqxmd.com/read/28058731/improved-intercostal-hifu-ablation-using-a-phased-array-transducer-based-on-fermat-s-spiral-and-voronoi-tessellation-a-numerical-evaluation
#5
Pascal Ramaekers, Mario Ries, Chrit T W Moonen, Martijn de Greef
PURPOSE: A major complication for abdominal High Intensity Focused Ultrasound (HIFU) applications is the obstruction of the acoustic beam path by the thoracic cage, which absorbs and reflects the ultrasonic energy leading to undesired overheating of healthy tissues in the pre-focal area. Prior work has investigated the determination of optimized transducer apodization laws, which allow for a reduced rib exposure whilst (partially) restoring focal point intensity through power compensation...
January 6, 2017: Medical Physics
https://www.readbyqxmd.com/read/28050658/development-of-a-searchable-database-of-cryoablation-simulations-for-use-in-treatment-planning
#6
F Edward Boas, Govindarajan Srimathveeravalli, Jeremy C Durack, Elena A Kaye, Joseph P Erinjeri, Etay Ziv, Majid Maybody, Hooman Yarmohammadi, Stephen B Solomon
PURPOSE: To create and validate a planning tool for multiple-probe cryoablation, using simulations of ice ball size and shape for various ablation probe configurations, ablation times, and types of tissue ablated. MATERIALS AND METHODS: Ice ball size and shape was simulated using the Pennes bioheat equation. Five thousand six hundred and seventy different cryoablation procedures were simulated, using 1-6 cryoablation probes and 1-2 cm spacing between probes. The resulting ice ball was measured along three perpendicular axes and recorded in a database...
January 3, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28041986/insomnia-symptoms-with-objective-short-sleep-duration-are-associated-with-systemic-inflammation-in-adolescents
#7
Julio Fernandez-Mendoza, Joshua H Baker, Alexandros N Vgontzas, Jordan Gaines, Duanping Liao, Edward O Bixler
Inflammation has been suggested as a potential pathway by which insomnia and short sleep can affect risk of morbidity in adults. However, few studies have examined the association of insomnia with inflammation in adolescents, despite accumulating evidence that pathophysiologic changes may already occur during this critical developmental period. The present study sought to examine the association of insomnia symptoms with systemic inflammation and the role of objective sleep duration in this association. Participants were 378 adolescents (16...
December 30, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28033450/association-of-iron-deficiency-anemia-with-hearing-loss-in-us-adults
#8
Kathleen M Schieffer, Cynthia H Chuang, James Connor, James A Pawelczyk, Deepa L Sekhar
Importance: Hearing loss in the US adult population is linked to hospitalization, poorer self-reported health, hypertension, diabetes, and tobacco use. Because iron deficiency anemia (IDA) is a common and easily correctable condition, further understanding of the association between IDA and all types of hearing loss in a population of US adults may help to open new possibilities for early identification and appropriate treatment. Objective: To evaluate the association between sensorineural hearing loss (SNHL) and conductive hearing loss and IDA in adults aged 21 to 90 years in the United States...
December 29, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28028738/risk-and-resilience-factors-associated-with-resident-burnout
#9
Deanna Chaukos, Emma Chad-Friedman, Darshan H Mehta, Laura Byerly, Alper Celik, Thomas H McCoy, John W Denninger
OBJECTIVE: We investigated hypothesized risk and resilience factors and their association with burnout in first year medicine and psychiatry residents at an urban teaching hospital in order to help guide the development of interventions targeted at reducing burnout. METHODS: We administered the Maslach Burnout Inventory (MBI), Perceived Stress Scale-10, Functional Assessment of Chronic Illness Therapy-Fatigue Scale, Penn State Worry Questionnaire, Patient Health Questionnaire-9 (depression symptoms), Revised Life Orientation Test (optimism), Self-Efficacy Questionnaire, Cognitive and Affective Mindfulness Scale, Interpersonal Reactivity Index Perspective-Taking Scale (empathy), and Measure of Current Status-Part A to first year medicine and psychiatry residents prior to initiation of clinical rotations in June...
December 27, 2016: Academic Psychiatry
https://www.readbyqxmd.com/read/28010820/a-parametric-study-of-thermal-therapy-of-skin-tissue
#10
Simão Nóbrega, Pedro J Coelho
A thermal therapy for cancer in skin tissue is numerically investigated using three bioheat conduction models, namely Pennes, thermal wave and dual-phase lag models. A laser is applied at the surface of the skin for cancer ablation, and the temperature and thermal damage distributions are predicted using the three bioheat models and two different modeling approaches of the laser effect. The first one is a prescribed surface heat flux, in which the tissue is assumed to be highly absorbent, while the second approach is a volumetric heat source, which is reasonable if the scattering and absorption skin effects are of similar magnitude...
January 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28008009/distribution-and-clinical-impact-of-functional-variants-in-50-726-whole-exome-sequences-from-the-discovehr-study
#11
Frederick E Dewey, Michael F Murray, John D Overton, Lukas Habegger, Joseph B Leader, Samantha N Fetterolf, Colm O'Dushlaine, Cristopher V Van Hout, Jeffrey Staples, Claudia Gonzaga-Jauregui, Raghu Metpally, Sarah A Pendergrass, Monica A Giovanni, H Lester Kirchner, Suganthi Balasubramanian, Noura S Abul-Husn, Dustin N Hartzel, Daniel R Lavage, Korey A Kost, Jonathan S Packer, Alexander E Lopez, John Penn, Semanti Mukherjee, Nehal Gosalia, Manoj Kanagaraj, Alexander H Li, Lyndon J Mitnaul, Lance J Adams, Thomas N Person, Kavita Praveen, Anthony Marcketta, Matthew S Lebo, Christina A Austin-Tse, Heather M Mason-Suares, Shannon Bruse, Scott Mellis, Robert Phillips, Neil Stahl, Andrew Murphy, Aris Economides, Kimberly A Skelding, Christopher D Still, James R Elmore, Ingrid B Borecki, George D Yancopoulos, F Daniel Davis, William A Faucett, Omri Gottesman, Marylyn D Ritchie, Alan R Shuldiner, Jeffrey G Reid, David H Ledbetter, Aris Baras, David J Carey
The DiscovEHR collaboration between the Regeneron Genetics Center and Geisinger Health System couples high-throughput sequencing to an integrated health care system using longitudinal electronic health records (EHRs). We sequenced the exomes of 50,726 adult participants in the DiscovEHR study to identify ~4.2 million rare single-nucleotide variants and insertion/deletion events, of which ~176,000 are predicted to result in a loss of gene function. Linking these data to EHR-derived clinical phenotypes, we find clinical associations supporting therapeutic targets, including genes encoding drug targets for lipid lowering, and identify previously unidentified rare alleles associated with lipid levels and other blood level traits...
December 23, 2016: Science
https://www.readbyqxmd.com/read/27990352/paranoid-individuals-with-schizophrenia-show-greater-social-cognitive-bias-and-worse-social-functioning-than-non-paranoid-individuals-with-schizophrenia
#12
Amy E Pinkham, Philip D Harvey, David L Penn
Paranoia is a common symptom of schizophrenia that may be related to how individuals process and respond to social stimuli. Previous investigations support a link between increased paranoia and greater social cognitive impairments, but these studies have been limited to single domains of social cognition, and no studies have examined how paranoia may influence functional outcome. Data from 147 individuals with schizophrenia were used to examine whether actively paranoid and non-paranoid individuals with schizophrenia differ in social cognition and functional outcomes...
March 2016: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/27986463/tamoxifen-differentially-regulates-mir-29b-1-and-mir-29a-expression-depending-on-endocrine-sensitivity-in-breast-cancer-cells
#13
Penn Muluhngwi, Abirami Krishna, Stephany L Vittitow, Joshua T Napier, Kirsten M Richardson, Mackenzie Ellis, Justin L Mott, Carolyn M Klinge
Endocrine-resistance develops in ∼40% of breast cancer patients after tamoxifen (TAM) therapy. Although microRNAs are dysregulated in breast cancer, their contribution to endocrine-resistance is not yet understood. Previous microarray analysis identified miR-29a and miR-29b-1 as repressed by TAM in MCF-7 endocrine-sensitive breast cancer cells but stimulated by TAM in LY2 endocrine-resistant breast cancer cells. Here we examined the mechanism for the differential regulation of these miRs by TAM in MCF-7 versus TAM-resistant LY2 and LCC9 breast cancer cells and the functional role of these microRNAs in these cells...
December 13, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27983580/insomnia-phenotypes-based-on-objective-sleep-duration-in-adolescents-depression-risk-and-differential-behavioral-profiles
#14
Julio Fernandez-Mendoza, Susan L Calhoun, Alexandros N Vgontzas, Yun Li, Jordan Gaines, Duanping Liao, Edward O Bixler
Based on previous studies on the role of objective sleep duration in predicting morbidity in individuals with insomnia, we examined the role of objective sleep duration in differentiating behavioral profiles in adolescents with insomnia symptoms. Adolescents from the Penn State Child Cohort (n = 397, ages 12-23, 54.7% male) underwent a nine-hour polysomnography (PSG), clinical history, physical examination and psychometric testing, including the Child or Adult Behavior Checklist and Pediatric Behavior Scale...
December 13, 2016: Brain Sciences
https://www.readbyqxmd.com/read/27976499/imidacloprid-seed-treatments-affect-individual-ant-behavior-and-community-structure-but-not-egg-predation-pest-abundance-or-soybean-yield
#15
Hannah J Penn, Andrew M Dale
BACKGROUND: Neonicotinoid seed treatments are under scrutiny because of their variable efficacy against crop pests and for their potential negative impacts on non-target organisms. Ants provide important biocontrol services in agroecosystems and can be indicators of ecosystem health. This study tested for effects of exposure to imidacloprid plus fungicide or fungicide treated seeds on individual ant survival, locomotion and foraging capabilities, and on field ant community structure, pest abundance, ant predation, and yield...
December 15, 2016: Pest Management Science
https://www.readbyqxmd.com/read/27966642/epoxygenated-fatty-acids-inhibit-retinal-vascular-inflammation
#16
Megan E Capozzi, Sandra S Hammer, Gary W McCollum, John S Penn
The objective of the present study was to assess the effect of elevating epoxygenated fatty acids on retinal vascular inflammation. To stimulate inflammation we utilized TNFα, a potent pro-inflammatory mediator that is elevated in the serum and vitreous of diabetic patients. In TNFα-stimulated primary human retinal microvascular endothelial cells, total levels of epoxyeicosatrienoic acids (EETs), but not epoxydocosapentaenoic acids (EDPs), were significantly decreased. Exogenous addition of 11,12-EET or 19,20-EDP when combined with 12-(3-adamantane-1-yl-ureido)-dodecanoic acid (AUDA), an inhibitor of epoxide hydrolysis, inhibited VCAM-1 and ICAM-1 expression and protein levels; conversely the diol product of 19,20-EDP hydrolysis, 19,20-DHDP, induced VCAM1 and ICAM1 expression...
December 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27957721/computational-simulation-of-the-predicted-dosimetric-impact-of-adjuvant-yttrium-90-pet-ct-guided-percutaneous-ablation-following-radioembolization
#17
Alexander S Pasciak, Abigail Lin, Christos Georgiades, Laura K Findeiss, Shannon Kauffman, Yong C Bradley
BACKGROUND: (90)Y PET/CT post-radioembolization imaging has demonstrated that the distribution of (90)Y in a tumor can be non-uniform. Using computational modeling, we predicted the dosimetric impact of post-treatment (90)Y PET/CT-guided percutaneous ablation of the portions of a tumor receiving the lowest absorbed dose. A cohort of fourteen patients with non-resectable liver cancer previously treated using (90)Y radioembolization were included in this retrospective study. Each patient exhibited potentially under-treated areas of tumor following treatment based on quantitative (90)Y PET/CT...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27933955/biphenyl-pyridazinone-derivatives-as-inhaled-pde4-inhibitors-structural-biology-and-structure-activity-relationships
#18
Jordi Gràcia, Maria Antonia Buil, Jordi Castro, Peter Eichhorn, Manel Ferrer, Amadeu Gavaldà, Begoña Hernández, Victor Segarra, Martin D Lehner, Imma Moreno, Lluís Pagès, Richard S Roberts, Jordi Serrat, Sara Sevilla, Joan Taltavull, Miriam Andrés, Judit Cabedo, Dolors Vilella, Elena Calama, Carla Carcasona, Montserrat Miralpeix
Cyclic nucleotide cAMP is a ubiquitous secondary messenger involved in a plethora of cellular responses to biological agents involving activation of adenylyl cyclase. Its intracellular levels are tightly controlled by a family of cyclic nucleotide degrading enzymes, the PDEs. In recent years, cyclic nucleotide phosphodiesterase type 4 (PDE4) has aroused scientific attention as a suitable target for anti-inflammatory therapy in respiratory diseases, particularly in the management of asthma and COPD. Here we describe our efforts to discover novel, highly potent inhaled inhibitors of PDE4...
December 8, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27932915/icollections-digitising-the-british-and-irish-butterflies-in-the-natural-history-museum-london
#19
Gordon Paterson, Sara Albuquerque, Vladimir Blagoderov, Stephen Brooks, Steve Cafferty, Elisa Cane, Victoria Carter, John Chainey, Robyn Crowther, Lyndsey Douglas, Joanna Durant, Liz Duffell, Adrian Hine, Martin Honey, Blanca Huertas, Theresa Howard, Rob Huxley, Ian Kitching, Sophie Ledger, Caitlin McLaughlin, Geoff Martin, Gerardo Mazzetta, Malcolm Penn, Jasmin Perera, Mike Sadka, Elisabetta Scialabba, Angela Self, Darrell J Siebert, Chris Sleep, Flavia Toloni, Peter Wing
BACKGROUND: The Natural History Museum, London (NHMUK) has embarked on an ambitious programme to digitise its collections . The first phase of this programme has been to undertake a series of pilot projects that will develop the necessary workflows and infrastructure development needed to support mass digitisation of very large scientific collections. This paper presents the results of one of the pilot projects - iCollections. This project digitised all the lepidopteran specimens usually considered as butterflies, 181,545 specimens representing 89 species from the British Isles and Ireland...
2016: Biodiversity Data Journal
https://www.readbyqxmd.com/read/27932464/role-of-inflammation-in-modulating-thrombotic-fibrinolytic-balance-in-venous-thrombosis
#20
EDITORIAL
Marc S Penn, Chinedu Igwe
No abstract text is available yet for this article.
December 9, 2016: Circulation Research
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