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https://www.readbyqxmd.com/read/28924264/neurocognitive-and-behavioral-functioning-in-adolescents-with-sleep-disordered-breathing-a-population-based-dual-energy-x-ray-absorptiometry-study
#1
S S Frye, J Fernandez-Mendoza, S L Calhoun, J Gaines, M D Sawyer, F He, D Liao, A N Vgontzas, E O Bixler
BACKGROUND/OBJECTIVES: Sleep disordered breathing (SDB) has been associated with neurocognitive and behavioral problems in young children; however, this association is less studied in adolescents. Evidence suggests that obesity plays a key role in the development of SDB, although its relative association with neurobehavioral functioning remains unclear. We examined whether SDB and obesity are associated with neurocognitive and behavior problems in adolescents. SUBJECTS/METHODS: 421 adolescents (17...
September 19, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28922946/temperature-simulation-of-microwave-ablation-based-on-improved-specific-absorption-rate-method-compared-to-phantom-measurements
#2
Hongjian Gao, Shuicai Wu, Xiaoru Wang, Rui Hu, Zhuhuang Zhou, Xuecong Sun
PURPOSE: To propose an improved specific absorption rate (SAR) computation method by incorporating a thermal conductivity item, develop mathematical simulation models based on the SAR, and enhance the accuracy of temperature simulation for 2450-MHz microwave fields. MATERIALS AND METHODS: Experimental data of 2450-MHz microwave antenna were obtained with a phantom and then new SAR equations were calculated according to Pennes bio-heat transfer equation. Next, the SAR equations were regarded as heating sources and SAR-derived temperature changes were simulated numerically; Finally, temperature measurement results were compared with simulation data to validate the accuracy of the new SAR method...
September 18, 2017: Computer Assisted Surgery (Abingdon, England)
https://www.readbyqxmd.com/read/28921504/g%C3%AE-12-facilitates-carbachol-induced-shortening-in-human-airway-smooth-muscle-by-modulating-phosphoinositide-3-kinase-mediated-activation-in-a-rhoa-dependent-manner
#3
Edwin J Yoo, Gaoyuan Cao, Cynthia J Koziol-White, Christie A Ojiaku, Krishna Sunder, Joseph A Jude, James V Michael, Hong Lam, Ivan Pushkarsky, Robert Damoiseaux, Dino Di Carlo, Kwangmi Ahn, Steven S An, Raymond B Penn, Reynold A Panettieri
BACKGROUND AND PURPOSE: Phosphoinositide 3-kinase (PI3K)-dependent activation of Rho kinase (ROCK) is necessary for agonist-induced human airway smooth muscle cell (HASMC) contraction, and inhibition of PI3K promotes bronchodilation of human small airways. The upstream mechanisms driving agonist-mediated PI3K/ROCK axis activation, however, remain unclear. Given the capacity of G12 family proteins to activate ROCK pathways in other cell types (Riobo and Manning, 2005), the role of G12 proteins in modulating M3 muscarinic acetylcholine receptor (M3R)-stimulated PI3K/ROCK activation and HASMC contraction was examined...
September 17, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28902836/hippocampal-ltp-and-contextual-learning-require-surface-diffusion-of-ampa-receptors
#4
A C Penn, C L Zhang, F Georges, L Royer, C Breillat, E Hosy, J D Petersen, Y Humeau, D Choquet
Long-term potentiation (LTP) of excitatory synaptic transmission has long been considered a cellular correlate for learning and memory. Early LTP (less than 1 h) had initially been explained either by presynaptic increases in glutamate release or by direct modification of postsynaptic AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor function. Compelling models have more recently proposed that synaptic potentiation can occur by the recruitment of additional postsynaptic AMPA receptors (AMPARs), sourced either from an intracellular reserve pool by exocytosis or from nearby extra-synaptic receptors pre-existing on the neuronal surface...
September 13, 2017: Nature
https://www.readbyqxmd.com/read/28893411/suicidal-thoughts-in-persons-treated-for-alcohol-dependence-the-role-of-selected-demographic-and-clinical-factors
#5
Marcin Ziółkowski, Damian Czarnecki, Jan Chodkiewicz, Krzysztof Gąsior, Artur Juczyński, Agata Biedrzycka, Ewa Gruszczyńska, Katarzyna Nowakowska-Domagała
Greater knowledge is needed of potential predictive factors for suicide in cases of alcohol addiction. Therefore, the aim of the study was to identify the socio-demographic variables and clinical factors associated with alcohol dependence which may have an influence on the occurrence of suicidal thoughts in alcohol-dependent patients. A group of 510 patients (396 male and 114 female) diagnosed with alcohol dependence syndrome were interviewed during the third week of therapy according to the Beck Depression Inventory (BDI), the Penn Alcohol Craving Scale (PACS) and the Short Alcohol Dependence Data Questionnaire (SADD)...
September 1, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28890107/real-time-imaging-of-vcam-1-mrna-in-tnf-%C3%AE-activated-retinal-microvascular-endothelial-cells-using-antisense-hairpin-dna-functionalized-gold-nanoparticles
#6
Md Imam Uddin, Ashwath Jayagopal, Alexis Wong, Gary W McCollum, David W Wright, John S Penn
Vascular cell adhesion molecule 1 (VCAM-1) is an important inflammatory biomarker correlating with retinal disease progression. Thus, detection of VCAM-1 mRNA expression levels at an early disease stage could be an important predictive biomarker to assess the risk of disease progression and monitoring treatment response. We have developed VCAM-1 targeted antisense hairpin DNA-functionalized gold nanoparticles (AS-VCAM-1 hAuNP) for the real time detection of VCAM-1 mRNA expression levels in retinal endothelial cells...
September 7, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28886145/application-of-a-whole-blood-mycobacterial-growth-inhibition-assay-to-study-immunity-against-mycobacterium-tuberculosis-in-a-high-tuberculosis-burden-population
#7
Richard Baguma, Adam Penn-Nicholson, Erica Smit, Mzwandile Erasmus, Jonathan Day, Lebohang Makhethe, Marwou de Kock, E Jane Hughes, Michele van Rooyen, Bernadette Pienaar, Lynnett Stone, Willem Hanekom, Michael J Brennan, Robert S Wallis, Mark Hatherill, Thomas J Scriba
The determinants of immunological protection against Mycobacterium tuberculosis (M.tb) infection in humans are not known. Mycobacterial growth inhibition assays have potential utility as in vitro surrogates of in vivo immunological control of M.tb. We evaluated a whole blood growth inhibition assay in a setting with high burden of TB and aimed to identify immune responses that correlate with control of mycobacterial growth. We hypothesized that individuals with underlying M.tb infection will exhibit greater M...
2017: PloS One
https://www.readbyqxmd.com/read/28886127/genome-wide-mirna-response-to-anacardic-acid-in-breast-cancer-cells
#8
David J Schultz, Penn Muluhngwi, Negin Alizadeh-Rad, Madelyn A Green, Eric C Rouchka, Sabine J Waigel, Carolyn M Klinge
MicroRNAs are biomarkers and potential therapeutic targets for breast cancer. Anacardic acid (AnAc) is a dietary phenolic lipid that inhibits both MCF-7 estrogen receptor α (ERα) positive and MDA-MB-231 triple negative breast cancer (TNBC) cell proliferation with IC50s of 13.5 and 35 μM, respectively. To identify potential mediators of AnAc action in breast cancer, we profiled the genome-wide microRNA transcriptome (microRNAome) in these two cell lines altered by the AnAc 24:1n5 congener. Whole genome expression profiling (RNA-seq) and subsequent network analysis in MetaCore Gene Ontology (GO) algorithm was used to characterize the biological pathways altered by AnAc...
2017: PloS One
https://www.readbyqxmd.com/read/28876554/surgical-anatomy-of-reduction-mammaplasty-a-historical-perspective-and-current-concepts
#9
A O Wamalwa, T Stasch, F W Nangole, S O Khainga
Reduction mammaplasty is the volumetric reduction in the bulk of the breast. Techniques have evolved from primarily reducing the breast bulk to reducing with emphasis on functional and aesthetic outcome. The deeper understanding of the surgical anatomy of the breast has guided this development. While Paulus Aegina (sixth century AD), Dieffenbach (1848) and Gaillard-Thomas (1882) set the pace in glandular reduction; Pousson (1897) and Dehner (1908) focused on breast ptosis. It took quite some time before the enigma of the vascularization to the nipple areolar complex could be solved...
March 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28872162/conservative-treatment-of-vestibular-schwannoma-growth-and-penn-acoustic-neuroma-quality-of-life-scale-in-french-language
#10
P A Oddon, M Montava, F Salburgo, M Collin, C Vercasson, J P Lavieille
The aim of this study was to determine the natural history of growth and quality of life (QoL) outcomes for vestibular schwannoma (VS) managed conservatively, and to validate the disease-specific Penn Acoustic Neuroma Quality-of-Life (PANQOL) scale in French language. We retrospectively studied 26 patients with VS managed conservatively. Patient characteristics and radiological findings were collected. Two scales were used to measure QoL: the Short Form-36 Health Survey (SF-36) and the PANQOL scale translated into French...
August 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28861705/multistep-translation-and-cultural-adaptation-of-the-penn-acoustic-neuroma-quality-of-life-scale-for-german-speaking-patients
#11
Julia Kristin, Marcel Fabian Glaas, Igor Stenin, Angelika Albrecht, Thomas Klenzner, Jörg Schipper, Katrin Eysel-Gosepath
BACKGROUND: Monitoring the health-related quality of life (HRQOL) for patients with vestibular schwannoma (VS) has garnered increasing interest. In German-speaking countries, there is no disease-specific questionnaire available similar to the "Penn Acoustic Neuroma Quality-of-life Scale" (PANQOL). METHOD: We translated the PANQOL for German-speaking patients based on a multistep protocol that included not only a forward-backward translation but also linguistic and sociocultural adaptations...
August 31, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28859910/numerical-solution-of-non-linear-dual-phase-lag-bioheat-transfer-equation-within-skin-tissues
#12
Dinesh Kumar, P Kumar, K N Rai
This paper deals with numerical modeling and simulation of heat transfer in skin tissues using non-linear dual-phase-lag (DPL) bioheat transfer model under periodic heat flux boundary condition. The blood perfusion is assumed temperature-dependent which results in non-linear DPL bioheat transfer model in order to predict more accurate results. A numerical method of line which is based on finite difference and Runge-Kutta (4,5) schemes, is used to solve the present non-linear problem. Under specific case, the exact solution has been obtained and compared with the present numerical scheme, and we found that those are in good agreement...
August 30, 2017: Mathematical Biosciences
https://www.readbyqxmd.com/read/28858964/improvement-through-small-cycles-of-change-lessons-from-an-academic-medical-center-emergency-department
#13
Amit Arbune, Sarah Wackerbarth, Penne Allison, Joseph Conigliaro
This article describes the experiences of a quality improvement team that used small cycles of change to improve the emergency department (ED) of an academic medical center. The role of EDs in the provision of healthcare continues to increase in importance. ED bottlenecks contribute to long waits and diminished outcomes for ED patients as well as more system-wide issues, such as inefficiencies in inpatient admission processes. The purpose of this "ED Operational Efficiency Project" was to reduce lengths of stay (LOS) for low-acuity patients...
September 2017: Journal for Healthcare Quality: Official Publication of the National Association for Healthcare Quality
https://www.readbyqxmd.com/read/28858697/post-conflict-struggles-as-networks-of-problems-a-network-analysis-of-trauma-daily-stressors-and-psychological-distress-among-sri-lankan-war-survivors
#14
Nuwan Jayawickreme, Candace Mootoo, Christine Fountain, Andrew Rasmussen, Eranda Jayawickreme, Rebecca F Bertuccio
A growing body of literature indicates that the mental distress experienced by survivors of war is a function of both experienced trauma and stressful life events. However, the majority of these studies are limited in that they 1) employ models of psychological distress that emphasize underlying latent constructs and do not allow researchers to examine the unique associations between particular symptoms and various stressors; and 2) use one or more measures that were not developed for that particular context and thus may exclude key traumas, stressful life events and symptoms of psychopathology...
August 24, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28858644/a-computational-theoretical-model-for-radiofrequency-ablation-of-tumor-with-complex-vascularization
#15
Y L Shao, B Arjun, H L Leo, K J Chua
Radiofrequency ablation (RFA) for liver tumors is a minimally invasive procedure that uses electrical energy and heat to destroy cancer cells. One of the critical factors that impedes its successful outcome is the thermal heat sink effects from complex vascular systems that give rise to incomplete destruction of the target tumor tissue, resulting in therapy failure. To better understand the thermal influence of the complex vascular system during RFA, this work proposes the employment of two 3D fractal tree-like branched networks to investigate which key factors of the tree-like vascular system impact heating process...
August 24, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28855605/attempts-to-replicate-genetic-associations-with-schizophrenia-in-a-cohort-from-north-india
#16
Suman Prasad, Triptish Bhatia, Prachi Kukshal, Vishwajit L Nimgaonkar, Smita N Deshpande, B K Thelma
Schizophrenia is a chronic, severe, heritable disorder. Genome-wide association studies, conducted predominantly among Caucasians, have indicated > 100 risk alleles, with most significant SNPs on chromosome 6. There is growing interest as to whether these risk alleles are relevant in other ethnic groups as well. Neither an Indian genome-wide association studies nor a systematic replication of GWAS findings from other populations are reported. Thus, we analyzed 32 SNPs, including those associated in the Caucasian ancestry GWAS and other candidate gene studies, in a north Indian schizophrenia cohort (n = 1009 patients; n = 1029 controls) using a Sequenom mass array...
August 30, 2017: NPJ Schizophrenia
https://www.readbyqxmd.com/read/28854880/understanding-the-implementation-of-maternity-waiting-homes-in-low-and-middle-income-countries-a-qualitative-thematic-synthesis
#17
Loveday Penn-Kekana, Shreya Pereira, Julia Hussein, Hannah Bontogon, Matthew Chersich, Stephen Munjanja, Anayda Portela
BACKGROUND: Maternity waiting homes (MWHs) are accommodations located near a health facility where women can stay towards the end of pregnancy and/or after birth to enable timely access to essential childbirth care or care for complications. Although MWHs have been implemented for over four decades, different operational models exist. This secondary thematic +analysis explores factors related to their implementation. METHODS: A qualitative thematic analysis was conducted using 29 studies across 17 countries...
August 31, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28854505/impact-of-prenatal-diagnosis-of-fetus-in-fetu
#18
E K Sewell, B Massa-Buck, E I Rubio, A N Massaro, A Badillo, E Puscasiu, R Broth, T Falika-King, B Nies, A Penn
Fetus in fetu (FIF) is an extremely rare condition (1/500,000 live births) in which a fetiform structure is incorporated into the body of its twin. FIF can be a diagnostic dilemma due to its similarity to a teratoma, but identification of FIF is important for subsequent medical and surgical management. We compare two cases of fetal masses diagnosed on prenatal imaging that were later identified as FIF through further radiological, surgical, and pathologic evaluation. We use these cases to illustrate key pre- and postnatal features of FIF and highlight the benefits of prenatal detection and follow-up for postnatal management...
August 23, 2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28853448/use-of-medicines-adherence-and-attitudes-to-medicines-among-persons-with-chronic-spinal-cord-injury
#19
H Høgholen, A Storhaug, K Kvernrød, E Kostovski, K K Viktil, L Mathiesen
STUDY DESIGN: A cross-sectional study. OBJECTIVES: To describe the use of medicines and adherence among persons with spinal cord injury (SCI). Further, to examine the influence of pain, spasms and beliefs about medicines on adherence. SETTING: Sunnaas Rehabilitation Hospital, Norway. METHODS: Persons (⩾18 years) with chronic SCI (more than 1-year post injury), using at least one drug regularly, and admitted for a follow-up stay at Sunnaas Rehabilitation Hospital were included...
August 29, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28844420/a-prospective-randomized-controlled-trial-to-identify-the-optimal-postoperative-pain-management-in-shoulder-arthroplasty-liposomal-bupivacaine-versus-continuous-interscalene-catheter
#20
Vani J Sabesan, Rajin Shahriar, Graysen R Petersen-Fitts, James D Whaley, Therese Bou-Akl, Matthew Sweet, Marc Milia
BACKGROUND: Shoulder arthroplasty is the fastest growing joint replacement surgery in the United States, and optimal postoperative pain management is critical to optimize outcomes for these surgeries. Liposomal bupivacaine (LB) has gained popularity for its potential to provide extended postoperative pain relief with possibly fewer side effects. The goal of this study was to assess the impact of LB compared with continuous interscalene nerve block (CISB) in terms of postoperative pain control, outpatient pain scores, and patient-reported and functional outcomes after shoulder arthroplasty surgery...
August 22, 2017: Journal of Shoulder and Elbow Surgery
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